CN101129441B - Rhodiola rosea capsule and its preparing method - Google Patents
Rhodiola rosea capsule and its preparing method Download PDFInfo
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- CN101129441B CN101129441B CN2007100500642A CN200710050064A CN101129441B CN 101129441 B CN101129441 B CN 101129441B CN 2007100500642 A CN2007100500642 A CN 2007100500642A CN 200710050064 A CN200710050064 A CN 200710050064A CN 101129441 B CN101129441 B CN 101129441B
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- 239000002775 capsule Substances 0.000 title claims abstract description 8
- 244000042430 Rhodiola rosea Species 0.000 title claims description 5
- 235000003713 Rhodiola rosea Nutrition 0.000 title claims description 5
- 238000000034 method Methods 0.000 title abstract description 3
- 241000121220 Tricholoma matsutake Species 0.000 claims abstract description 34
- 241000229143 Hippophae Species 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims description 36
- 235000003935 Hippophae Nutrition 0.000 claims description 25
- 239000008187 granular material Substances 0.000 claims description 19
- 239000000706 filtrate Substances 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 13
- 241000208340 Araliaceae Species 0.000 claims description 9
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 9
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 9
- 230000001476 alcoholic effect Effects 0.000 claims description 9
- 235000008434 ginseng Nutrition 0.000 claims description 9
- 238000000643 oven drying Methods 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 230000002265 prevention Effects 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 241001165494 Rhodiola Species 0.000 abstract 3
- 241000608170 Gymnadenia conopsea Species 0.000 abstract 2
- 235000003145 Hippophae rhamnoides Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 208000035240 Disease Resistance Diseases 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 235000013402 health food Nutrition 0.000 description 5
- 206010002660 Anoxia Diseases 0.000 description 4
- 241000976983 Anoxia Species 0.000 description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 4
- 206010021143 Hypoxia Diseases 0.000 description 4
- 229930003268 Vitamin C Natural products 0.000 description 4
- 230000007953 anoxia Effects 0.000 description 4
- 230000004223 radioprotective effect Effects 0.000 description 4
- 235000019154 vitamin C Nutrition 0.000 description 4
- 239000011718 vitamin C Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 230000002519 immonomodulatory effect Effects 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
Disclosed are a rhodiola root capsule and a production method thereof, wherein the raw materials of the active constituents include rhodiola root 55-65, pine mushroom 15-25, seabuckthorn fruit 10-20, gymnadenia cono-psea 5-15, and the preparing process consists of disintegrating pine mushroom into mesh fines, grilling rhodiola root, seabuckthorn fruit and gymnadenia cono-psea with water, filtrating, drying, disintegrating, charging pine mushroom fines, mixing homogenously and loading into capsules. The capsule of the invention can effectively improve the disease resistance and epidemic prevention capability of human body.
Description
(1) technical field:
A kind of Rhodiola rosea capsules and preparation method thereof belongs to the human natural health care, particularly is the health food of raw material with the plant, and its preparation method.
(2) background technology:
Modern society, huge work and life stress make that people's health problem is more and more serious, and the disease-resistant epidemic prevention ability of human body constantly descends, and people need obtain healthy required nutrient substance easily by market, to improve body disease-resistant epidemic prevention ability.At present, the health food that improves the disease-resistant epidemic prevention ability of human body on the market is a lot, but the subject matter that these health foods exist is that to be used to prepare its active component raw material numerous, at least tens the flavor raw materials, at most tens the flavor raw materials, cause production routine many, the product cost height causes these health foods can not popularize in the crowd.
(3) summary of the invention:
The problem to be solved in the present invention provides a kind of its active component raw material of preparation few, the reasonable science of material combination at above deficiency exactly, can effectively improve the health food of the disease-resistant epidemic prevention ability of human body.Its technical scheme is as follows:
It mainly comprises the raw material of following weight parts:
Radix Rhodiolae 55-65, Tricholoma matsutake (lto et lmai) Singer 15-25, Fructus Hippophae 10-20.
In order to reach better effect, raw material of the present invention also comprises Fructus Citri Sarcodactylis ginseng 5-15 part.
Preparation method of the present invention may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 150-200 order fine powder;
2) Radix Rhodiolae, Fructus Hippophae are added 6--8 times of water gaging, decoct and extract 2-3 time, each 2-3 hour, filter, merging filtrate refilters, and filtrate is concentrated into the extractum of relative density 1.20--1.25;
3) with above-mentioned extract dry, be ground into 150-200 order fine powder, add 30-40 part starch mixing, granulate with the 75%--95% alcoholic solution, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, mixing, 60--70 ℃ of oven drying at low temperature incapsulates.
If also with the combination of Fructus Citri Sarcodactylis ginseng, its preparation method is:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 150-200 order fine powder;
2) Radix Rhodiolae, Fructus Hippophae, Fructus Citri Sarcodactylis are participated in 6--8 times of water gaging, decoct and extract 2-3 time, each 2-3 hour, filter, merging filtrate refilters, and filtrate is concentrated into the extractum of relative density 1.20--1.25;
3) with above-mentioned extract dry, be ground into 150-200 order fine powder, add 30-40 part starch mixing, granulate with the 75%--95% alcoholic solution, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, mixing, 60--70 ℃ of oven drying at low temperature incapsulates.
Be used for the valley floor, Qinghai-Tibet that raw material Radix Rhodiolae of the present invention derives from 4000 meters of Qinghai-Tibet height above sea level, contained rhodioside has resisting fatigue, anoxia enduring, resisting microwave radiation and to nervous system and metabolic dual regulation, and has the effect of altitude environment " adaptogen " sample.Have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic effect.Tricholoma matsutake (lto et lmai) Singer derives from the forest of Qinghai-Tibet height above sea level 3000-4000 rice and a kind of natural edible bacterium in the shrub, and modern medicine study shows that Tricholoma matsutake (lto et lmai) Singer has radiation-resistant effect.Fructus Hippophae is also adopted Qinghai-Tibet wild Fructus Hippophae, contain tens kinds of bioactive substances that human body is necessary in the Fructus Hippophae extract, its vitamin content per 100 restrains in the Fructus Hippophaes up to more than 100 milligrams, beta-carotene is more than 10 milligrams, unsaturated fatty acid is greater than 90%, and wherein the content of SOD is four times of Radix Ginseng.The clinical discovery Fructus Hippophae extract is to people's cardiovascular and cerebrovascular vessel, digestion and immune system, and to enhancing metabolism, defying age, radioprotective, anticancer etc. all having a remarkable efficacy.Radix Rhodiolae compatibility Tricholoma matsutake (lto et lmai) Singer and Fructus Hippophae, snowy region activity of drug ingredients composition height, two-way activation, conditioning synchronously.Fructus Citri Sarcodactylis ginseng regulate the flow of vital energy and in.Four match, the tonifying YANG YIN nourishing, and tonifying both YIN and YANG consolidates the training source, and giving consideration to both the incidental and fundamental can effectively improve the disease-resistant epidemic prevention ability of human body.Product has immunomodulating, resisting fatigue, anoxia enduring, radioprotective and replenishes the necessary health cares such as vitamin C of human body.
Advantage compared with prior art of the present invention is: prepare 1, that its active component raw material is few, material combination rationally and science, Radix Rhodiolae compatibility Tricholoma matsutake (lto et lmai) Singer, Fructus Hippophae, snowy region activity of drug ingredients composition height, two-way activation, conditioning synchronously, Radix Rhodiolae, Tricholoma matsutake (lto et lmai) Singer, Fructus Hippophae, Fructus Citri Sarcodactylis ginseng match, the tonifying YANG YIN nourishing, tonifying both YIN and YANG consolidates the training source, giving consideration to both the incidental and fundamental can effectively improve the disease-resistant epidemic prevention ability of human body.Product has immunomodulating, resisting fatigue, anoxia enduring, radioprotective and replenishes the necessary health cares such as vitamin C of human body.2, production process is simple, has reduced production cost, is beneficial in the general population to popularize.3, product of the present invention does not contain sugar, and it is extensive to be suitable for the crowd.
(4) description of drawings:
Accompanying drawing is a process chart of the present invention.
(5) specific embodiment:
Embodiment one:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 60, Tricholoma matsutake (lto et lmai) Singer 25, Fructus Hippophae 15.
Its preparation method may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 200 order fine powders;
2) Radix Rhodiolae, Fructus Hippophae are added 6 times of water gagings, decoct and extract 2 times, each 3 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 75 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20--1.25 under the 0.1Mpa condition;
3) with above-mentioned extract dry, be ground into 200 order fine powders, add 30 parts of starch mixings, granulate with 75% alcoholic solution, reclaim ethanol, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, 65 ℃ of oven drying at low temperatures incapsulate.
Granulate, encapsulated, relative humidity should be controlled at below 55% when storing, to reduce the influence of moisture pharmaceutical properties and stability.Product of the present invention should carry out packing in 100,000 grades of clean areas.
Contain rhodioside 〉=800mg, vitamin C 80-110mg in the per 100 gram products of product of the present invention.Product has immunomodulating, resisting fatigue, anoxia enduring, radioprotective and replenishes the necessary health cares such as vitamin C of human body.
Instructions of taking and dose: oral, every day three times, each 1-2 grain.
[specification]: 500mg/ grain.
Embodiment two:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 55, Tricholoma matsutake (lto et lmai) Singer 25, Fructus Hippophae 20.
Its preparation method may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 150 order fine powders;
2) Radix Rhodiolae, Fructus Hippophae are added 8 times of water gagings, decoct and extract 2 times, each 2.5 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 70 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20 under the 0.08Mpa condition;
3) with above-mentioned extract dry, be ground into 150 order fine powders, add 35 parts of starch mixings, granulate with 80% alcoholic solution, reclaim ethanol, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, mixing, 70 ℃ of oven drying at low temperatures incapsulate, promptly.
Embodiment three:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 65, Tricholoma matsutake (lto et lmai) Singer 20, Fructus Hippophae 20.
Its preparation method may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 180 fine powders;
2) Radix Rhodiolae, Fructus Hippophae are added 7 times of water gagings, decoct and extract 3 times, each 2 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 80 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.25 under the 0.1Mpa condition;
3) with above-mentioned extract dry, be ground into 180 order fine powders, add 40 parts of starch mixings, granulate with 95% alcoholic solution, reclaim ethanol, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, 65 ℃ of oven drying at low temperatures incapsulate, promptly.
Embodiment four:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 60, Tricholoma matsutake (lto et lmai) Singer 20, Fructus Hippophae 15, Fructus Citri Sarcodactylis ginseng 5.
Its preparation method may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 200 order fine powders;
2) Radix Rhodiolae, Fructus Hippophae, Fructus Citri Sarcodactylis are participated in 6 times of water gagings, decoct and extract 2 times, each 3 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 70 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.25 under the 0.1Mpa condition;
3) with above-mentioned extract dry, be ground into 200 order fine powders, add 30 parts of starch mixings, granulate with 80% alcoholic solution, reclaim ethanol, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, 65 ℃ of oven drying at low temperatures incapsulate.
Embodiment five:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 55, Tricholoma matsutake (lto et lmai) Singer 15, Fructus Hippophae 15, Fructus Citri Sarcodactylis ginseng 15.
Its preparation method may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 150 order fine powders;
2) Radix Rhodiolae, Fructus Hippophae, Fructus Citri Sarcodactylis are participated in 8 times of water gagings, decoct and extract 3 times, each 2 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 70 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20 under the 0.08Mpa condition;
3) with above-mentioned extract dry, be ground into 150 order fine powders, add 35 parts of starch mixings, granulate with 75% alcoholic solution, reclaim ethanol, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, 60 ℃ of oven drying at low temperatures incapsulate.
Embodiment six:
Take by weighing each raw material by following weight proportion:
Radix Rhodiolae 65, Tricholoma matsutake (lto et lmai) Singer 25, Fructus Hippophae 20, Fructus Citri Sarcodactylis ginseng 15.
Its preparation method may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into 180 order fine powders;
2) Radix Rhodiolae, Fructus Hippophae, Fructus Citri Sarcodactylis are participated in 7 times of water gagings, decoct and extract 2 times, each 2.5 hours, filter with 300 order filter clothes, merging filtrate refilters, and is 80 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20 under the 0.09Mpa condition;
3) with above-mentioned extract dry, be ground into 180 order fine powders, add 40 parts of starch mixings, granulate with 95% alcoholic solution, reclaim ethanol, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder, 70 ℃ of oven drying at low temperatures incapsulate.
Claims (2)
1. Rhodiola rosea capsules is characterized in that preparing the raw material that its active component raw material is following weight portion:
Radix Rhodiolae 55-65, Tricholoma matsutake (lto et lmai) Singer 15-25, Fructus Hippophae 10-20, Fructus Citri Sarcodactylis ginseng 5-15.
2. the preparation method of the described Rhodiola rosea capsules of claim 1 is characterized in that may further comprise the steps:
1) it is standby Tricholoma matsutake (lto et lmai) Singer powder to be broken into fine powder;
2) Radix Rhodiolae, Fructus Hippophae, Fructus Citri Sarcodactylis are participated in 6--8 times of water gaging, decoct and extract 2-3 time, each 2-3 hour, filter, merging filtrate refilters, is 70 ℃～80 ℃ with filtrate in temperature, and vacuum is the extractum that is concentrated into relative density 1.20--1.25 under 0.08～0.1Mpa condition;
3) with above-mentioned extract dry, be ground into fine powder, add 30-40 part starch mixing, granulate, in granule, add the Tricholoma matsutake (lto et lmai) Singer fine powder with the 75%--95% alcoholic solution, mixing, 60--70 ℃ of oven drying at low temperature incapsulates.
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| CN2007100500642A CN101129441B (en) | 2007-09-20 | 2007-09-20 | Rhodiola rosea capsule and its preparing method |
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| CN2007100500642A CN101129441B (en) | 2007-09-20 | 2007-09-20 | Rhodiola rosea capsule and its preparing method |
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| CN101129441B true CN101129441B (en) | 2011-05-18 |
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| CN101352236B (en) * | 2008-09-17 | 2012-02-15 | 王振宇 | Big fruit sea-buckthorn compound fatigue-resistant powder and preparation method thereof |
| CN102329715A (en) * | 2011-09-20 | 2012-01-25 | 成都圣弘源科贸有限公司 | Compound Rhodiola rosea wine and preparation method thereof |
| CN102872267A (en) * | 2012-10-12 | 2013-01-16 | 绿之韵生物工程集团有限公司 | Traditional Chinese medicine composition for resisting fatigue and tonifying kidney, and preparation method thereof |
| CN103789167B (en) * | 2014-01-21 | 2016-02-24 | 甘孜州华康进出口有限责任公司 | A kind of Buddha's hand Lacebark pine fungus wine and preparation method thereof |
| CN107927774A (en) * | 2017-10-24 | 2018-04-20 | 青海鑫池源生物科技开发有限公司 | A kind of health rhodiola capsule and preparation method thereof |
| CN108308605A (en) * | 2018-02-11 | 2018-07-24 | 甘肃御宝泽农垦御米生物开发有限公司 | Soft capsule for health care |
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