CN109010514A - Composition, health care product and the preparation method of altitude sickness prevention - Google Patents
Composition, health care product and the preparation method of altitude sickness prevention Download PDFInfo
- Publication number
- CN109010514A CN109010514A CN201811088341.3A CN201811088341A CN109010514A CN 109010514 A CN109010514 A CN 109010514A CN 201811088341 A CN201811088341 A CN 201811088341A CN 109010514 A CN109010514 A CN 109010514A
- Authority
- CN
- China
- Prior art keywords
- powder
- altitude sickness
- parts
- composition
- sickness prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
This application discloses a kind of composition of altitude sickness prevention, the raw material components including following parts by weight: 12-18 parts of pueraria root powder, 12-18 parts of instant green tea powder, 8-12 parts of medlar powder, 8-12 parts of ginseng and 0.3-0.8 parts of Saussurea involucrata culture.Disclosed herein as well is a kind of preparation methods of the composition of above-mentioned altitude sickness prevention, and the health care product comprising above-mentioned altitude sickness prevention composition.Present application addresses the drug of existing altitude sickness prevention or health care product single, the undesirable technical problems of altitude sickness prevention effect that easily causes different degrees of adverse reaction and effective component.
Description
Technical field
This application involves field of health care products, in particular to the composition, health care product and preparation of a kind of altitude sickness prevention
Method.
Background technique
Altitude sickness (high altitude reaction), also known as altitude sickness, mountain sickness, are strictly the one of altitude sickness
Kind parting.It is that human body rapidly enters 3000 meters of height above sea level or more High altitude environmental exposures after hypobaric hypoxia environment, due to oxygen in atmospheric pressure
Pressure drop is low, and body reduces low-oxygen environment tolerance, it is difficult to adapt to and cause anoxic, it is inadaptable thus to cause a series of plateau
Disease.Altitude sickness is the exclusive common disease in highlands.When the disease incidence of altitude sickness and speed of going up a hill, height above sea level, inhabitation
Between and constitution etc. it is related.Common symptom has headache, insomnia, appetite stimulator, tired, expiratory dyspnea etc..
Altitude sickness is divided into acute, chronic two major classes: acute high altitude reaction (acute high- according to morbidity is suddenly slow
Altitude reaction) often there are double forehead pain, palpitaition, uncomfortable in chest, shortness of breath, anorexia, nausea and vomiting etc., some cases
There is lip and nail matrix cyanosis;Chronic mountain reaction (chrollic high altitude reaction) is that Acute Altitude is anti-
Should continue 3 months or more symptom not disappearance persons, performance headache, dizziness, insomnia, failure of memory, absent minded, palpitaition,
Shortness of breath, appetite stimulator, indigestion, numb in every limb and face oedema, occur arrhythmia cordis sometimes or transience is fainted.Plateau is anti-
If the state of an illness answered cannot be alleviated in time, it will cause very big damage or even threat to life to human body.
Altitude sickness takes some measures when usually can be by entering before plateau or falling ill delay altitude sickness
Solution, such as abundant rest, oxygen therapy, treatment of changing places, the health care product or drug for taking altitude sickness prevention be wherein effective measures it
One, the health care product or drug for being usually used in altitude sickness prevention are broadly divided into two classes: one kind is that occur for eliminating in altitude sickness
The symptoms such as headache, nausea Western medicine, such as nifedipine, dexamethasone, acetazolamide, easily cause it is different degrees of not
Good reaction;It is another kind of be adjust function of human body, with anti-oxidant, endurance, anoxia tolerance function Chinese medicine, as Rhodiola rosea capsules,
American ginseng buccal tablet etc., effective component is single, and altitude sickness prevention effect is undesirable.
In conclusion studying, a kind of compatibility is reasonable, and plateau can be effectively relieved in promotion body hypoxia-bearing and oxidation resistance
The altitude sickness prevention composition of the symptoms such as the headache, nausea, insomnia, appetite stimulator, the tired, expiratory dyspnea that occur in reaction and guarantor
Strong product, become technical solution urgently to be resolved.
Summary of the invention
The main purpose of the application is to provide that a kind of compatibility is reasonable, and composition and the guarantor of altitude sickness can be effectively relieved
Strong product, easily cause different degrees of adverse reaction and effective component to solve drug or the health care product of existing altitude sickness prevention
It is single, the undesirable technical problem of altitude sickness prevention effect.
To achieve the goals above, according to a first aspect of the present application, a kind of composition of altitude sickness prevention is provided, including
The raw material components of following parts by weight: 12-18 parts of pueraria root powder, 12-18 parts of instant green tea powder, 8-12 parts of medlar powder,
The Saussurea involucrata culture of 8-12 parts of ginseng and 0.3-0.8 part.
Further, the composition of the altitude sickness prevention includes the material component of following parts by weight: 15 parts of maca
Powder, 15 parts of instant green tea powder, 10 parts of medlar powder, 10 parts of ginseng and 0.5 part of Saussurea involucrata culture.
To achieve the goals above, according to a second aspect of the present application, a kind of composition of above-mentioned altitude sickness prevention is provided
Preparation method, comprising the following steps: take pueraria root powder, instant green tea powder and medlar powder spare in proportion, take ginseng in proportion
And Saussurea involucrata culture is prepared into ginseng concentration powder respectively and Saussurea involucrata culture powder is spare, and the raw material got ready is uniformly mixed and is obtained
Mixed powder obtains the composition of the altitude sickness prevention after sterilizing.
Further, it is sliced, freezes after the preparation method of the pueraria root powder is the following steps are included: take the rhizome of maca to clean
Drying to water content is 9%-10%, is crushed to 300 mesh by micronizer, obtains the pueraria root powder.
Further, it crushes, takes after the preparation method of the instant green tea powder is the following steps are included: take green tea to dry
Green tea is put into distilled water heating extraction 2~4 hours of 12 times of amounts after crushing, and the distilled water of 5 times of amounts is added in filter residue by filtering
Secondary extraction 2~4 hours is heated, filtrate twice is merged after refiltering, is concentrated under reduced pressure, obtains the speed after vacuum freeze drying
Molten green tea powder.
Further, the preparation method of the medlar powder is the following steps are included: take mature fructus lycii at 50-60 DEG C
Drying, is crushed to 200 mesh through micronizer, obtains the medlar powder.
Further, the preparation method of powder is concentrated the following steps are included: fresh ginseng is taken to crush in the ginseng, and 5-10 is added
The ethyl alcohol of amount heats extraction 2~4 hours again, extracts 2~4 times, filtering and merging filtrate, is concentrated under reduced pressure, vacuum refrigeration is done
The ginseng concentration powder is obtained after dry.
Further, the preparation method of the Saussurea involucrata culture powder is the following steps are included: take Saussurea involucrata culture at 60-85 DEG C
Lower microwave drying, then through airslide disintegrating mill to 300 mesh, obtain the Saussurea involucrata culture powder.
To achieve the goals above, according to the third aspect of the application, a kind of health care product of altitude sickness prevention is provided, including
The composition of above-mentioned altitude sickness prevention and pharmaceutically acceptable auxiliary material.
Further, the pharmaceutically acceptable auxiliary material includes maltodextrin, xylo-oligosaccharide, microcrystalline cellulose, tristearin
One of sour magnesium, taurine or guarana extract are a variety of.
Further, the dosage form of the health care product includes tablet, capsule, granule and oral solution.
In the embodiment of the present application, made using pueraria root powder, instant green tea powder, medlar powder, ginseng and Saussurea involucrata culture
The composition that altitude sickness prevention is formed for raw material has reached that effectively improve body resistance to by the reasonable compatibility of above-mentioned effective component
The purpose of anoxic and oxidation resistance, thus realize can be effectively relieved the headache occurred in altitude sickness, nausea, insomnia,
The technical effect of the symptoms such as appetite stimulator, tired, expiratory dyspnea, and then solve the drug or health care product of existing altitude sickness prevention
It is single to easily cause different degrees of adverse reaction and effective component, the undesirable technical problem of altitude sickness prevention effect.
Specific embodiment
It is right below in conjunction with the embodiment of the present application in order to make those skilled in the art more fully understand application scheme
Technical solution in the embodiment of the present application is clearly and completely described, it is clear that described embodiment is only the application one
Partial embodiment, instead of all the embodiments.Based on the embodiment in the application, those of ordinary skill in the art are not having
Every other embodiment obtained under the premise of creative work is made, shall fall within the protection scope of the present application.
It is not arranged it should be noted that the term " includes " in the description and claims of this application is intended to covering
His includes, for example, containing the product or method of a series of raw materials or step, it is not necessary to those of be limited to be clearly listed raw material
Or step, but may include other raw materials or step being not clearly listed or intrinsic for these products or method.
In the absence of conflict, the features in the embodiments and the embodiments of the present application can be combined with each other.Below will
It is described in detail the application in conjunction with the embodiments.
Embodiment 1
A kind of composition of altitude sickness prevention, the raw material components including following parts by weight: 12 parts of pueraria root powder, 12 parts
Instant green tea powder, 8 parts of medlar powder, 8 parts of ginseng and 0.3 part of Saussurea involucrata culture.
The preparation method of above-mentioned altitude sickness prevention composition, comprising the following steps: take pueraria root powder, instant green tea powder in proportion
Spare with medlar powder, taking ginseng and Saussurea involucrata culture to be prepared into respectively in proportion, powder is concentrated in ginseng and Saussurea involucrata culture powder is standby
With, by the raw material got ready be uniformly mixed obtain mixed powder, the composition of the altitude sickness prevention is obtained after sterilizing.Wherein, Ma
The preparation method of coffee powder the following steps are included: the rhizome of maca is taken to clean after be sliced, freeze-drying to water content is 9%, is passed through
Micronizer is crushed to 300 mesh, obtains the pueraria root powder;The preparation method of instant green tea powder is the following steps are included: take green tea
Crushed after drying tea leaves, green tea after crushing taken to be put into distilled water heating extraction 2 hours of 12 times of amounts, filtering, by filter residue plus
Enter the secondary extraction of distilled water heating of 5 times of amounts 2 hours, filtrate twice is merged after refiltering, is concentrated under reduced pressure, vacuum freeze drying
After obtain the instant green tea powder;The preparation method of medlar powder is the following steps are included: take mature fructus lycii to dry at 50 DEG C
It is dry, 200 mesh are crushed to through micronizer, obtain the medlar powder;Ginseng be concentrated powder preparation method the following steps are included:
It takes fresh ginseng to crush, the 5-10 times of ethyl alcohol measured heating extraction 2 hours is added, extracts 4 times, filtering and merging filtrate, through subtracting
The ginseng concentration powder is obtained after pressure concentration, vacuum freeze drying;The preparation method of Saussurea involucrata culture powder is the following steps are included: take
Saussurea involucrata culture microwave drying at 60 DEG C, then through airslide disintegrating mill to 300 mesh, obtain the Saussurea involucrata culture powder.It is above-mentioned mixed
Closing step selects batch mixer to be mixed, and incorporation time is 10 minutes.
Embodiment 2
A kind of composition of altitude sickness prevention, the raw material components including following parts by weight: 15 parts of pueraria root powder, 15 parts
Instant green tea powder, 10 parts of medlar powder, 10 parts of ginseng and 0.5 part of Saussurea involucrata culture.
The preparation method of the composition of above-mentioned altitude sickness prevention, comprising the following steps: take pueraria root powder, instant green tea in proportion
Powder and medlar powder are spare, and ginseng and Saussurea involucrata culture is taken to be prepared into ginseng concentration powder and Saussurea involucrata culture powder respectively in proportion
It is spare, the raw material got ready is uniformly mixed and obtains mixed powder, the composition of the altitude sickness prevention is obtained after sterilizing.Wherein,
The preparation method of pueraria root powder the following steps are included: the rhizome of maca is taken to clean after be sliced, freeze-drying to water content is 10%, warp
It crosses micronizer and is crushed to 300 mesh, obtain the pueraria root powder;The preparation method of instant green tea powder is the following steps are included: take green
It is crushed after tea drying tea leaves, takes the distilled water heating that green tea is put into 12 times of amounts after crushing to extract 3.5 hours, filtering will filter
The secondary extraction of distilled water heating 3 hours of 5 times of amounts are added in slag, and filtrate twice is merged after refiltering, is concentrated under reduced pressure, vacuum refrigeration
The instant green tea powder is obtained after drying;The preparation method of medlar powder is the following steps are included: take mature fructus lycii in 58 DEG C
Lower drying is crushed to 200 mesh through micronizer, obtains the medlar powder;The preparation method that powder is concentrated in ginseng includes following
Step: taking fresh ginseng to crush, and the ethyl alcohol heating of 8 times of amounts extraction 2.5 hours is added, extracts 3 times, filtering and merging filtrate,
It is concentrated under reduced pressure, obtains the ginseng concentration powder after vacuum freeze drying;The preparation method of Saussurea involucrata culture powder includes following step
It is rapid: to take Saussurea involucrata culture microwave drying at 70 DEG C, then through airslide disintegrating mill to 300 mesh, obtain the Saussurea involucrata culture powder.On
Stating mixing step selects batch mixer to be mixed, and incorporation time is 20 minutes.
Embodiment 3
A kind of composition of altitude sickness prevention, the raw material components including following parts by weight: 18 parts of pueraria root powder, 18 parts
Instant green tea powder, 12 parts of medlar powder, 12 parts of ginseng and 0.8 part of Saussurea involucrata culture.
The preparation method of the composition of above-mentioned altitude sickness prevention, comprising the following steps: take pueraria root powder, instant green tea in proportion
Powder and medlar powder are spare, and ginseng and Saussurea involucrata culture is taken to be prepared into ginseng concentration powder and Saussurea involucrata culture powder respectively in proportion
It is spare, the raw material got ready is uniformly mixed and obtains mixed powder, the composition of the altitude sickness prevention is obtained after sterilizing.Wherein,
The preparation method of pueraria root powder the following steps are included: the rhizome of maca is taken to clean after be sliced, freeze-drying to water content is 10%, warp
It crosses micronizer and is crushed to 300 mesh, obtain the pueraria root powder;The preparation method of instant green tea powder is the following steps are included: take green
It is crushed after tea drying tea leaves, takes the distilled water heating that green tea is put into 12 times of amounts after crushing to extract 4 hours, filtering, by filter residue
The secondary extraction of distilled water heating of 5 times of amounts 4 hours is added, filtrate twice is merged after refiltering, is concentrated under reduced pressure, vacuum refrigeration is done
The instant green tea powder is obtained after dry;The preparation method of medlar powder is the following steps are included: take mature fructus lycii at 60 DEG C
Drying, is crushed to 200 mesh through micronizer, obtains the medlar powder;The preparation method that powder is concentrated in ginseng includes following step
It is rapid: to take fresh ginseng to crush, the ethyl alcohol heating of 10 times of amounts extraction 4 hours is added, extracts 2 times, filtering and merging filtrate, through subtracting
The ginseng concentration powder is obtained after pressure concentration, vacuum freeze drying;The preparation method of Saussurea involucrata culture powder is the following steps are included: take
Saussurea involucrata culture microwave drying at 85 DEG C, then through airslide disintegrating mill to 300 mesh, obtain the Saussurea involucrata culture powder.It is above-mentioned mixed
Closing step selects batch mixer to be mixed, and incorporation time is 30 minutes.
Embodiment 4
A kind of health care product of altitude sickness prevention, preparation method includes the following steps: obtained described anti-in Example 1
The composition of altitude sickness, is added 10% xylo-oligosaccharide and 5% microcrystalline cellulose is uniformly mixed, and is pressed into using tablet press machine
Tablet, specification are 0.5g/ piece.
Embodiment 5
A kind of health care product of altitude sickness prevention, preparation method includes the following steps: obtained described anti-in Example 2
The composition of altitude sickness, is added 0.05% taurine and ethanol in proper amount wetting is added in 15% maltodextrin, with 20 meshes
Granulation, obtains wet granular, and make pellet, to dry in 60 DEG C of temperature to moisture contents through baking oven be 3%, using 20 mesh sieves, by object
Expect that the 0.35% of gross mass is added magnesium stearate, mixes 10 minutes, after mixing, capsule is made, specification is 0.25g/.
Embodiment 6
A kind of health care product of altitude sickness prevention, preparation method includes the following steps: obtained described anti-in Example 3
The composition of altitude sickness, is added 0.03% taurine, and 0.02% guarana extract and 12% maltodextrin are added
Ethanol in proper amount wetting, is pelletized with 12 meshes, obtains wet granular, and make pellet is in 50 DEG C of temperature drying to moisture contents through baking oven
5%, magnesium stearate is added by the 0.25% of material gross mass into dried particle, mixes 15 minutes, after mixing, makes
With 10 mesh and 30 mesh sieves, granule is made, specification is 5g/ bags.
The oxygen deficit tolerance of 1 altitude sickness prevention health care product of experimental example is tested
1, experiment equipment and animal
Experimental animal
Healthy male ICR mouse, cleaning grade, weight 18-22g.
Experiment equipment and reagent
1000ml ground wide-mouth bottle soda lime vaseline
2, experimental group
This experiment is divided into blank group and medicine group;
Blank group selects physiological saline as sample;
Drug component is control group and embodiment 4-6 group: control group, selects Rhodiola rosea capsules as sample, root of kirilow rhodiola glue
Capsule, 0.3g/, strong word G20160234 eats in state;Embodiment 4-6 group selects the altitude sickness prevention prepared in embodiment 4-6 respectively
Health care product.
3, oxygen deficit tolerance experimental method
By experiment mice 50, it is randomly divided into 5 groups, i.e. blank group, control group, embodiment 4-6 group, every group 10.Each group
Intragastric administration on mice administration, daily each 1 time of morning and evening, successive administration 15d.In last stomach-filling next day, mouse is put into and fills 10g soda lime
1000mL ground wide-mouth bottle in, apply appropriate vaseline sealing bottleneck, record mouse is from being put into when wide-mouth bottle to breathing stops
Time is recorded as the hypoxia death time.Prolonged survival period rate (%)=(the medicine group time-to-live-blank group time-to-live)/
Blank group time-to-live × 100%.
4, experimental result
Statistical procedures are carried out to experimental data, experimental result is shown in Table 1:
1 mouse oxygen deficit tolerance experimental result of table
Compared with blank group, * p < 0.05, * * p < 0.01
As seen from the above table, the health care product in the embodiment of the present application 4-6 can significantly extend the time-to-live of hypoxia mice, table
It is bright its with apparent oxygen lack resistant function, while it is good to prove that the composition of altitude sickness prevention in embodiment 1-3 has
Substituted phenyl-lactic acid, wherein the oxygen lack resistant function of health care product is best in embodiment 6.
The clinical trial of 2 altitude sickness prevention health care product of experimental example
1, laboratory sample
Laboratory sample is divided into four groups: control group, using Rhodiola rosea capsules, 0.3g/, strong word G20160234 eats in state;Implement
Example 4-6 group, selects the altitude sickness prevention health care product prepared in embodiment 4-6 respectively.
2, clinical trial object
Selected case is to during in October, 2017 to have headache, nausea, mistake Tibet province Grade A hospital in October, 2016
The patient for being diagnosed as acute high altitude reaction of the symptoms such as dormancy, appetite stimulator, tired, expiratory dyspnea, amounts to 100, wherein 78
Example male, 22 women, the age was at 20-54 years old.It is randomly divided into 4 groups, every group 25, between each group in terms of gender, age, the state of an illness
No difference of science of statistics.
3, clinical test methods
The 4 groups of cases that will have divided at random are taken medicine as follows respectively: control group, Rhodiola rosea capsules, oral administration, and one
Secondary 2,2 times a day;4 groups of embodiment, oral administration, one time 2,3 times a day;5 groups of embodiment, oral administration, one time 4,
3 times a day;6 groups of embodiment, oral administration, one time 1 packet, 1 times a day.Take 14 days it is as a treatment course.
4, curative effect determinate standard
Cure: the symptoms such as headache, nausea, insomnia, appetite stimulator, tired, expiratory dyspnea completely disappear;Effective: headache is disliked
The symptoms partial disappearance such as the heart, insomnia, appetite stimulator, tired, expiratory dyspnea;It is invalid: headache, nausea, insomnia, appetite stimulator, tired
The symptoms such as tired, expiratory dyspnea are not improved.Calculate efficient (%)=(curing case load+effective case load)/total case load
× 100%.
5, clinical trial results
The health care product clinical trial results of altitude sickness prevention are shown in Table 2:
The clinical trial results of 2 altitude sickness prevention health care product of table
Group | Case load | It cures | Effectively | In vain | It is efficient |
Control group | 25 | 3 | 14 | 8 | 68% |
Embodiment group 4 | 25 | 5 | 16 | 4 | 84% |
Embodiment group 5 | 25 | 8 | 12 | 5 | 80% |
Embodiment group 6 | 25 | 10 | 12 | 3 | 88% |
As seen from the above table, head can be effectively relieved relative to existing Rhodiola rosea capsules in the application altitude sickness prevention health care product
Bitterly, the symptoms such as nausea, insomnia, appetite stimulator, tired, expiratory dyspnea imitate acute high altitude reaction with good clinical treatment
Fruit, wherein the health care product clinical efficacy in embodiment 6 is best.
By the above experimental example 1 and experimental example 2 it is found that the composition compatibility for the altitude sickness prevention that the application provides is reasonable, system
Standby obtained health care product has the function of resist oxygen lack, and the headache occurred in altitude sickness, nausea, insomnia, food can be effectively relieved
It is intended to decline, is tired, the symptoms such as expiratory dyspnea, and there is good clinical efficacy, in addition, also to pass through anti-oxidant animal real by applicant
The composition and health care product obtained for demonstrating the altitude sickness prevention in the embodiment of the present application have excellent oxidation resistance.
The foregoing is merely preferred embodiment of the present application, are not intended to limit this application, for the skill of this field
For art personnel, various changes and changes are possible in this application.Within the spirit and principles of this application, made any to repair
Change, equivalent replacement, improvement etc., should be included within the scope of protection of this application.
Claims (10)
1. a kind of composition of altitude sickness prevention, which is characterized in that the raw material components including following parts by weight: 12-18 parts
Pueraria root powder, 12-18 parts of instant green tea powder, 8-12 parts of medlar powder, 8-12 parts of ginseng and the training of 0.3-0.8 parts of saussurea involucrata
Support object.
2. the composition of altitude sickness prevention according to claim 1, which is characterized in that the raw material including following parts by weight
Component: 15 parts of pueraria root powder, 15 parts of instant green tea powder, 10 parts of medlar powder, 10 parts of ginseng and the training of 0.5 part of saussurea involucrata
Support object.
3. the preparation method of the composition of altitude sickness prevention of any of claims 1 or 2, which comprises the following steps:
It takes pueraria root powder, instant green tea powder and medlar powder spare in proportion, ginseng and Saussurea involucrata culture is taken to be prepared into respectively in proportion
Powder is concentrated in ginseng and Saussurea involucrata culture powder is spare, and the raw material got ready is uniformly mixed and obtains mixed powder, obtains after sterilizing described
The composition of altitude sickness prevention.
4. the preparation method of the composition of altitude sickness prevention according to claim 3, which is characterized in that the pueraria root powder
Preparation method the following steps are included: the rhizome of maca is taken to clean after be sliced, freeze-drying to water content is 9%-10%, by super
Atomizer is crushed to 300 mesh, obtains the pueraria root powder.
5. the preparation method of the composition of altitude sickness prevention according to claim 3, which is characterized in that the instant green tea
The preparation method of powder the following steps are included: green tea is taken to dry after crush, take green tea after crushing to be put into the steamings of 12 times of amounts
Distilled water heating extraction 2~4 hours, filter residue was added the secondary extraction of distilled water heating 2~4 hours of 5 times of amounts, refilters by filtering
After merge filtrate twice, be concentrated under reduced pressure, obtain the instant green tea powder after vacuum freeze drying.
6. the preparation method of the composition of altitude sickness prevention according to claim 3, which is characterized in that the medlar powder
Preparation method the following steps are included: mature fructus lycii is taken to dry at 50-60 DEG C, be crushed to 200 mesh through micronizer,
Obtain the medlar powder.
7. the preparation method of the composition of altitude sickness prevention according to claim 3, which is characterized in that the ginseng concentration
The preparation method of powder is the following steps are included: take fresh ginseng to crush, the ethyl alcohol heating that 5-10 times of addition is measured extraction 2~4 hours, leaching
It mentions 2~4 times, filtering and merging filtrate, is concentrated under reduced pressure, obtains the ginseng concentration powder after vacuum freeze drying;The snow
The preparation method of lotus culture powder is the following steps are included: take Saussurea involucrata culture microwave drying at 60-85 DEG C, then through air-flow crushing
Machine obtains the Saussurea involucrata culture powder to 300 mesh.
8. a kind of health care product of altitude sickness prevention, which is characterized in that anti-including the described in any item anti-plateaus of claim 1 to 2
The composition and pharmaceutically acceptable auxiliary material answered.
9. the health care product of altitude sickness prevention according to claim 8, which is characterized in that the pharmaceutically acceptable auxiliary material
Including one of maltodextrin, xylo-oligosaccharide, microcrystalline cellulose, magnesium stearate, taurine or guarana extract or a variety of.
10. the health care product of altitude sickness prevention according to claim 8, which is characterized in that the dosage form of the health care product includes
Tablet, capsule, granule and oral solution.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811088341.3A CN109010514A (en) | 2018-09-18 | 2018-09-18 | Composition, health care product and the preparation method of altitude sickness prevention |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811088341.3A CN109010514A (en) | 2018-09-18 | 2018-09-18 | Composition, health care product and the preparation method of altitude sickness prevention |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109010514A true CN109010514A (en) | 2018-12-18 |
Family
ID=64616743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811088341.3A Pending CN109010514A (en) | 2018-09-18 | 2018-09-18 | Composition, health care product and the preparation method of altitude sickness prevention |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109010514A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111000967A (en) * | 2019-12-26 | 2020-04-14 | 陕西克林维尔信息科技有限公司 | Combined formula for resisting altitude stress specially developed for children and preparation method thereof |
CN112972549A (en) * | 2021-02-21 | 2021-06-18 | 施懿宸 | Health product for resisting altitude reaction and production equipment |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101073345A (en) * | 2006-05-17 | 2007-11-21 | 刘国祥 | Oxygen-resisting tea |
CN105748551A (en) * | 2016-03-11 | 2016-07-13 | 聊城大学 | Composition for improving anoxia tolerance |
CN106668321A (en) * | 2017-01-09 | 2017-05-17 | 宁夏早康生物科技有限公司 | Preparation method of radix ginseng and Chinese wolfberry fruit composition, and product and application thereof |
-
2018
- 2018-09-18 CN CN201811088341.3A patent/CN109010514A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101073345A (en) * | 2006-05-17 | 2007-11-21 | 刘国祥 | Oxygen-resisting tea |
CN105748551A (en) * | 2016-03-11 | 2016-07-13 | 聊城大学 | Composition for improving anoxia tolerance |
CN106668321A (en) * | 2017-01-09 | 2017-05-17 | 宁夏早康生物科技有限公司 | Preparation method of radix ginseng and Chinese wolfberry fruit composition, and product and application thereof |
Non-Patent Citations (3)
Title |
---|
叶文卉等: "玛咖多糖胶囊对小鼠抗疲劳耐缺氧及免疫功能的影响", 《安徽科技学院学报》 * |
周湘洁等: "雪莲培养细胞提取物的抗急性低压缺氧作用机制研究", 《中华航空航天医学杂志》 * |
彭亮等: "玛咖缓解小鼠体力疲劳功效的实验研究", 《云南医药》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111000967A (en) * | 2019-12-26 | 2020-04-14 | 陕西克林维尔信息科技有限公司 | Combined formula for resisting altitude stress specially developed for children and preparation method thereof |
CN112972549A (en) * | 2021-02-21 | 2021-06-18 | 施懿宸 | Health product for resisting altitude reaction and production equipment |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104026446B (en) | A kind of it is suitable for nutritional meal replacement powder that hyperglycemia population takes and preparation method thereof | |
CN100563697C (en) | Rhodiola rosea hippophae rhamnoides patch and preparation method thereof | |
CN100542584C (en) | Compound hippophae rhamnoides lozenge and preparation method thereof | |
CN101297704B (en) | Health care food for protecting liver and manufacturing method thereof | |
CN115120683A (en) | Raw material composition, traditional Chinese medicine fermentation product, preparation method and application thereof | |
CN106806853B (en) | Traditional Chinese medicine composition for relieving physical fatigue and/or improving anoxia endurance, preparation method and application thereof | |
CN104784505A (en) | Dendrobium officinale healthcare product with auxiliary blood glucose reducing function and preparation method thereof | |
CN106362020B (en) | A kind of pine pollen composition and preparation method thereof with improvement defecating feces excretion | |
CN104383259A (en) | Bitter gourd and mulberry leaf chromium-rich capsule and preparation method thereof | |
CN109010514A (en) | Composition, health care product and the preparation method of altitude sickness prevention | |
CN102266452A (en) | Chinese medicinal composition for enhancing anoxia endurance and preparation method and application thereof | |
CN114344351A (en) | Selenium-rich ganoderma lucidum spore powder capsule and preparation method thereof | |
CN104738716A (en) | Food therapy composition for rhinitis, trachitis or asthma and preparation method of food therapy composition | |
CN104095994B (en) | It is a kind of for Chinese medicine composition of functions of removing chloasma and preparation method thereof | |
CN101991659A (en) | Preparation with functions of clearing heat and releasing toxin and preparation method | |
CN102885884B (en) | Granule for treating poultry bacterial diseases and method for preparing granule | |
CN107158286B (en) | Traditional Chinese medicine composition for treating respiratory tract injury induced symptoms caused by haze and preparation method thereof | |
CN101653542A (en) | Medicinal composition for treating acute and chronic bronchitis and preparation method | |
CN102091135A (en) | Bezoar antidotal pills (tables and capsules) containing bezoar cultured in vitro and preparation method thereof | |
CN110917312B (en) | Chinese patent medicine for treating children's spleen-lung qi deficiency type cough variant asthma and preparation method thereof | |
CN1060663C (en) | Compound Tibet capillary artemisia patent medicine | |
CN102225082A (en) | Medicament for preventing and treating diabetes and complications thereof and preparation method thereof | |
CN114632126B (en) | Traditional Chinese medicine combination medicine for treating functional constipation and preparation method and application thereof | |
CN107261079A (en) | Application of the dragon and tiger jintan in prevention and/or treatment diabetes medicament is prepared | |
CN102579713B (en) | Traditional Chinese medicine for treating children obesity and preparation method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181218 |