CN101653542A - Medicinal composition for treating acute and chronic bronchitis and preparation method - Google Patents
Medicinal composition for treating acute and chronic bronchitis and preparation method Download PDFInfo
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Abstract
The invention aims to develop a medicinal composition and a preparation method. The medicinal composition is characterized in that the medicinal composition inherits the essence of the ancient Chinesemedicinal prescription 'ephedra, apricot kernel, gypsum, and licorice decoction' and is prepared elaborately by adopting modern technology; meanwhile, the medicinal composition has the effects of clearing, reducing, diffusing and freeing, and organically combines the effects of clearing the lung and discharging heat, diffusing lung qi and reducing and clearing turbid phlegm; moreover, the medicinal composition has the functions of relieving cough, dispelling phlegm, relieving panting, resisting inflammation, bacteriostasis, improving cellular immunity and humoral immunity, clearing heat and freeing lung and relieving cough and panting; therefore, the medicinal composition can be used to treat phlegm-heat lying depressed in the lung caused by acute attack of acute bronchitis and chronic bronchitis with the symptoms of cough and shortness of breath, or panting, yellow phlegm or ungratifying coughing of phlegm, fever, angina, dry stool, yellow or slimy yellow tongue coat, and the like. The preparation method comprises the following steps: taking medicinal materials including raw gypsum, wild buckwheat rhizome, heartleaf houttuynia herb, ephedra herb (mix fried), bitter almond kernel(mix fried), unibract fritillary bulb, Japanese ardisia herb, loquat leaf, perilla fruit (fried), liquorice root (mix fried), and the like to obtain extract powder of cough and panting relieving granules through selection, medicine washing, medicine cutting, drying, processing, crushing, blending, extraction, separation, condensation, and the like; and taking the extract powder, cane sugar and dextrin to make granules of the medicinal composition through wet granulation, drying, granule adjusting, total mixing, granule subpackaging and packaging.
Description
One. technical field.
The present invention relates to a kind of pharmaceutical composition and preparation method for the treatment of acute/chronic bronchitis, belong to field of medicaments, is a kind of medicine for treatment to acute/chronic bronchitis.
Two. technical background.
" interior through coughing opinion " proposes " vital organs of the human body all make us coughing, and not merely lung also ".Bright Zhang Jiebin " with surplus sight it, then wanting of cough ended only two cards, how are two cards? one says diseases caused by exogenous pathogenic factor, and one says internal injury, and to the greatest extent ... but among the two, when distinguishing negative and positive, when a minute deficiency and excess ear ".
The acute bronchitis of modern medicine is how relevant with being invaded by exogenous pathogen, no matter is affected by the cold or wind heat, all can due to illness evil closing lung qi, and body fluid must not spreading, and is strongly fragrant and give birth to hotly, and poly-liquid becomes expectorant, forms the card of expectorant heat stagnation lung.Acute episode of chronic bronchitis many with deficiency of both the splenic and pulmonary QI usually, interior living phlegm-damp, a sense exopathogen also can be strongly fragrant and fire-transformation, the card of satisfying into expectorant heat, so expectorant heat stagnation lung is that lung is one of common syndrome, it promptly is the square medicine of establishing at above-mentioned pathogenesis that clear cloperastine is breathed heavily granule.
(1), pharmacodynamic study.
Clear cloperastine is breathed heavily granule and can be prolonged ammonia and cause the incubation period of coughing, and reduces the cough number of times, promotes phenol red discharge from trachea; Can alleviate the contraction of the isolated helical strips of guinea due to the histamine, alleviate the swollen and mouse dimethylbenzene ear expanding of the rat carrageenan foot sole of the foot; Promote the super validity response of delayed of cleaning up exponential sum sheep red blood cell sensitization of carbon granules in the mice blood, and promote the generation of hemolytic antibody.Extracorporeal bacteria inhibitor test shows that clearly cloperastine breathes heavily granule golden Portugal bacterium, streptococcus and streptococcus pneumoniae, shigella flexneri, salmonella typhi, escherichia coli are all had inhibitory action in various degree.Studies confirm that clearly that cloperastine is breathed heavily granule and had cough-relieving, eliminates the phlegm, relievings asthma, antiinflammatory, effect such as antibacterial, and can strengthen cell and humoral immune function.
(2), toxicological study.
Animal acute toxicity test shows the maximum tolerated dose of the oral this product of mice more than 60 times, and observes a week behavior of mice outward appearance, main organs no abnormality seen.
Long-term toxicity test for animals: with the Wistar rat is animal subject, promptly be equivalent to 60 times of clinical dosage and 20 times with 30g/kg and 10g/kg and gavage 50 days continuously to rat, the result shows relatively no significant difference of administration group rat general behavior, hemogram, hepatic and renal function, organ coefficient and blank group.Difference that the histological examination heart, liver, spleen, lung, kidney, adrenal gland, thymus, uterus and testis compare with the blank treated animal that there are no significant.
The clinical research safety detects, and does not find it to the heart, liver, kidney, urine, just conventional toxic and side effects and mucocutaneous untoward reaction, shows that this product is safe.
(3), clinical research.
According to State Food and Drug Administration (1999) ZL-15 file, by four tame hospitals such as Dongzhimen Hospital, Beijing Univ of Traditional Chinese Medicine clear cloperastine is breathed heavily granule and carried out clinical research.Do paired observation with tangerine electuary, adopt at random, contrast, blind trial method, select acute bronchitis, acute episode of chronic bronchitis (expectorant heat syndrome) to be object of study, observe 441 examples altogether, treat 301 examples; Therefore matched group 140 examples, four tame hospital observed results do not have center effect, carry out statistical analysis after the addition.The Western medicine colligation efficacy analysis, treatment group: cure-remarkable-effectiveness rate 70.8%; Total effective rate 92.6%, matched group: cure-remarkable-effectiveness rate 49.3%; Total effective rate 81.4% has significant difference (P＜0.01).Primary symptom is coughed, expectorant, breathe heavily the individual event symptoms and therapeutic effect, cough: treatment group cure-remarkable-effectiveness rate 76.7%; Total effective rate 96.3%, matched group cure-remarkable-effectiveness rate 55.7%; Total effective rate 85.0% has significant difference (P＜0.01).Cough up phlegm: treatment group cure-remarkable-effectiveness rate 78.1%; Total effective rate 96.0%, matched group cure-remarkable-effectiveness rate 54.3%; Total effective rate 87.1% has significant difference (P＜0.01).Pant: treatment group cure-remarkable-effectiveness rate 67.9%; Total effective rate 90.6%, matched group cure-remarkable-effectiveness rate 48.0%; Total effective rate 72.0% is learned by statistics and is handled there was no significant difference (P＞0.01).Traditional Chinese medical science disease efficacy analysis, treatment group cure-remarkable-effectiveness rate 73.1%, total effective rate 94.4%, matched group cure-remarkable-effectiveness rate 52.9%, total effective rate 84.3% has significant difference (P＜0.01).
Three. goal of the invention.
The present invention is the elite of a kind of succession Chinese medicine ancient prescription of exploitation " MAXINGSHIGAN TANG ", adopts modern crafts to make with extra care and forms; Clearly, change, a surname, logical and execute, with lung heat clearing expel the heat-evil, opening lung-energy, the turbid combination of Qinghua expectorant; Cough-relieving, eliminate the phlegm, relieving asthma, antiinflammatory, antibacterial, strengthen cellular immunization and humoral immunization; Has reducing heat and dispersing lung-QI, the effect of relieving cough and asthma; Be used for acute bronchitis, acute episode of chronic bronchitis and belong to expectorant heat stagnation lung card, disease is seen: even cough pant, cough up phlegm yellow skin or not well, heating out of breath, pharyngalgia, dry stool, yellow fur or yellow greasy etc. pharmaceutical composition and preparation method thereof.
Four. technical scheme.
1, formula range.
Gypsum Fibrosum: 1-1000kg, Rhizoma Fagopyri Dibotryis: 1-1000kg, Herba Houttuyniae: 1-1000kg, Herba Ephedrae (processing): 1-1000kg, Semen Armeniacae Amarum (processing): 1-1000kg, Bulbus Fritillariae Cirrhosae: 1-1000kg, Herba Ardisiae Japonicae: 1-1000kg, Folium Eriobotryae: 1-1000kg, Fructus Perillae (stir-fry): 1-1000kg, Radix Glycyrrhizae (processing): 1-1000kg.
The solubilizing agent kind weight proportion scope that the present invention uses following one or more.
Binding agent: dextrin 1-30%, carboxymethyl cellulose 1-30%, gelatine size 1-30%, mucialga of arabic gummy 1-30%, sucrose 1-30%, lactose 1-30%.
Antiseptic: sodium benzoate 1-99%, Potassium Benzoate 1-99%, sorbic acid 1-99%, dehydroacetic acid 1-99%.
Correctives: sucrose 0.1-100kg, glucose 0.1-100kg, fructose 0.1-100kg, liquid glucose 1-99%.
Other classes: ethanol 1-99%.
2, preparation method.
Get that medical materials such as Gypsum Fibrosum, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Herba Ephedrae, Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Herba Ardisiae Japonicae, Folium Eriobotryae, Fructus Perillae, Radix Glycyrrhizae are selected, wash, cut medicine, drying, the process of preparing Chinese medicine, fragmentation, batching, extraction, separation, step such as concentrate and obtain clearly cloperastine and breathe heavily the granule extract powder; Get clearly cloperastine breathe heavily granule extract powder and sucrose, dextrin through wet granulation, drying, granulate, always mix, granule packing, packing promptly get granule.
Five, technological merit.
Advantage of the present invention is: prescription is unique, and method for making is reasonable; Acute/chronic bronchitis there is good therapeutic effect.
Six, embodiment.
6.1 select.
Gypsum Fibrosum, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Herba Ephedrae, Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Herba Ardisiae Japonicae, Folium Eriobotryae, Fructus Perillae, Radix Glycyrrhizae, above-mentioned 10 flavor medical materials are selected respectively meticulously, remove impurity and non-medicinal part, the weight of weighing medical material, impurity and non-medicinal part, and record respectively; Medical material dress Turnover Box (bag) seals, and labels, and changes next procedure.
6.2 wash.
6.2.1 Herba Ardisiae Japonicae, Semen Armeniacae Amarum, Rhizoma Fagopyri Dibotryis.
Above-mentioned 3 flavors are put respectively in the medicine-washing machine, are washed till no dust with drinking water, and Rhizoma Fagopyri Dibotryis is put in the demulcen groove, add low amounts of water, cover with wet cloth, moisten 2～3 hours, and are permeable most, standby to medicine.
6.2.2 Bulbus Fritillariae Cirrhosae, Gypsum Fibrosum, Fructus Perillae, Herba Ephedrae, Radix Glycyrrhizae, Herba Houttuyniae, Folium Eriobotryae.
With above-mentioned 7 flavors, respectively put in the net basket and wash to there not being dust with drinking water, Radix Glycyrrhizae is put in the demulcen groove, add low amounts of water, cover with wet cloth, moistened 1～2 hour, permeable most, standby to medicine.
6.3 cut medicine.
With Folium Eriobotryae, Radix Glycyrrhizae, Rhizoma Fagopyri Dibotryis, the Herba Houttuyniae medicine cutter cutting of cleaning.
6.3.1 Folium Eriobotryae is cut into silk (filament length 5-10mm) with medicine cutter, and is standby.
6.3.2 Herba Houttuyniae is cut into chunks (segment length 10-15mm) with medicine cutter, and is standby.
6.3.3 Radix Glycyrrhizae, Rhizoma Fagopyri Dibotryis cut sheet (the thick about 2-4mm of sheet), and be standby.
6.4 it is dry.
With the good medical material of cutting in 6.3, and other medical materials of cleaning are with hot air circulation drying baker dryings.To be dried to moisture content≤10.0% o'clock, take out the cold of drying in the air, pack in the clean container, go into intermediate station and please test standby.
6.5 concoct.
6.5.1 with dried Herba Ephedrae, Radix Glycyrrhizae, temperature 200-350 ℃, time 30-40 minute.Fry to tack-free, standby.
6.5.2 dried Semen Armeniacae Amarum, Fructus Perillae are fried, temperature 200-350 ℃, time 20-30 minute, standby.
6.6 it is broken.
With the Semen Armeniacae Amarum fragmentation after the Bulbus Fritillariae Cirrhosae after the oven dry, Gypsum Fibrosum and the process of preparing Chinese medicine, standby.
6.6.1 Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae becomes coarse powder with coarse granule pulverizer powder, and is standby.
6.6.2 Gypsum Fibrosum adopts the crusher in crushing in bulk, and is standby.
6.7 batching.
Take by weighing the above-mentioned medical material of respectively distinguishing the flavor of in batches by prescription, put in the clean turnover bag.Through check errorless after, according to the requirement of separately further processed it is sent to separately processing post.
6.8 extract.
6.8.1 Bulbus Fritillariae Cirrhosae (percolation).
The Bulbus Fritillariae Cirrhosae coarse powder put soaks in the medicine groove, with 70% ethanol moistening 2 hours, it is fully expanded after, layering drops in the percolation jar, adds 70% ethanol, flood to begin percolation after 48 hours, till percolation to the liquid of filtering was clarified, filter liquid and medicinal residues were standby.
6.8.2 Herba Houttuyniae (carrying volatile oil).
6.8.2.1 water extraction.
The Herba Houttuyniae section is put in the 0.5T multi-function extractor, add 8 times of water gagings, carry volatile oil with steam distillation.With the volatile oil warehouse-in that extracts, please test; Medicinal liquid and medicinal residues are standby.
6.8.2.2 supercritical extraction extracts volatile oil.
Get Herba Houttuyniae section supercritical fluid extraction volatile oil.Impose a condition: in the scope of extracting pressure 10～25MPa, 33～48 ℃ of extraction temperature, CO2 flow 2～4L/min.Earlier extraction kettle and separating still are carried out preheating, storage is irritated and is then cooled off.When reaching predetermined temperature, open CO
2Gas cylinder is supplied gas, and opens high-pressure pump and boost, and when reaching predetermined pressure, the beginning cycling extraction is regulated CO
2Flow behind the constant temperature and pressure, after the extraction scheduled time, is collected extract from separating still, and is standby.
6.8.3 Herba Ephedrae (processing), Semen Armeniacae Amarum (stir-fry), Fructus Perillae (stir-fry), Herba Ardisiae Japonicae, Radix Glycyrrhizae (processing), Rhizoma Fagopyri Dibotryis, Folium Eriobotryae (soak earlier, decoct) place above-mentioned seven flavor medicine together and to soak the medicine groove, soak into 1 hour, and be standby.
6.8.4 Gypsum Fibrosum put is decocted first 05 hour in the multi-function extractor, add seven flavor medicine material such as the Herba Ephedrae of soaking 1 hour and Bulbus Fritillariae Cirrhosae, Herba Houttuyniae medicinal residues, add water, decoct each 2 hours 3 times.3 decocting liquids and Herba Houttuyniae water extract are merged, filter, standby.
6.9 separate.
6.9.1 the liquid of filtering of Bulbus Fritillariae Cirrhosae is successively centrifugal by horizontal centrifuge and tube centrifuge, and clear liquid is standby, medicinal residues discard.
6.9.2 the extracting solution under the 6.8.4 item is centrifugal by horizontal centrifuge and high speed tube centrifuge, discard residue, clear liquid is standby.
6.10 concentrate.
6.10.1 the liquid of filtering of the Bulbus Fritillariae Cirrhosae after centrifugal is squeezed into economic benefits and social benefits and concentrate to be received in the cream jar, reclaim ethanol to there not being the alcohol flavor, standby.
Concentrate in the receipts cream jar 6.10.2 the medicinal liquid after centrifugal in the 6.9.2 item is squeezed into economic benefits and social benefits, be condensed into clear paste, the Bulbus Fritillariae Cirrhosae alcohol extraction clear paste behind the ethanol is reclaimed in adding, weighs decals, warehouse-in.
6.11 6.10 clear paste of producing are tiled in the vacuum drying oven stainless steel disc vacuum drying.Dry back blanking is pulverized and is fine powder to clean plastic bag.
6.12 pretreatment.
Dextrin is sieved one time with vibrosieve powder filter.
Sucrose is pulverized one time with pulverizer (80 order), sieved one time with vibrosieve powder filter.
6.13 batching.
Regulation is in batches inferior in the prescription: 0.5 ten thousand bags; In batches: 20,000 bags; Inferior lot number: 4.Check before the allotment whether measurement instrument is normal, and the double system of checking is observed in operation.
Breathe heavily granule extractum (the root a tree name is extracted workshop actual extracting quantity) by the inferior cloperastine that takes by weighing in batches clearly of prescription, dextrin, sucrose, allotment is equipped with 4 Asias and criticizes altogether. and measure Herba Houttuyniae oil, 95% ethanol by formula ratio, clout is return.Mouth is tightened in deployed material pack, good seal in the cream liquid packaging container, and it is temporary standby to stick on material label.
6.14 granulate.
6.14.1 load weighted inferior clear cloperastine is in batches breathed heavily granule extractum; dextrin; sucrose is put in the blender of high-speed mixing granulating machine; mix (at a slow speed) 5～8 minutes; add 95% ethanol; mix (at a slow speed) 2 minutes; discharging is granulated made soft material with waving granulation machine; made wet granular is tiled in the dry pot of boiling drier; the hermetically drying device is set 75-80 ℃ of inlet temperature, leaving air temp 60-65 ℃; the careful steam valve of opening; make the inlet temperature in the exsiccator slowly be raised up to design temperature, start is dry, after dry 30 minutes; can start stirring arm; about 1.5～2.0 hours of whole drying time, to measure dried granule moisture content and answer≤4.0%, qualified back discharging is to clean container.
6.14.2 dried granule is put vibrosieve powder filter to sieve.The gained granule is put in the three-dimensional motion mixer, and intransitable bulky grain and fine powder are done tailing and handled, but infra criticize when producing and pulverize with pulverizer, granulate again.
6.14.3 dried granule is in batches put the interior mixing of three-dimensional motion blender 10 minutes.
Herba Houttuyniae oil is added 95% ethanol, be mixed.
Get the granule behind the batch mixing, spray into the Herba Houttuyniae oil alcoholic solution, granule is put into blender again and mixed 10 minutes, open discharging opening, be discharged in the clean container, the weighing labeling is sent intermediate station.
6.15 granule packing.
Adjust Aluminium-coating Packer to following state, 90～110 ℃ of vertical sealing roller involution temperature, 110～120 ℃ of vertically sealed roller involution temperature, the alarm temperature of humidostat is set in about 20 ℃.90～100 bags/minute of separate-loading packagings; Empty bag forming of start rolling inspection and sealing situation are packed granule in the drug bucket of auto-filling-packing machine into after qualified, and start is carried out packing, loading amount 10g/ bag, content uniformity ± 4.0%; Will check loading amount every 20 minutes in equipment running process, the sealing situation of casual inspection medicated bag is picked out and is not conformed to product.
Aluminum-plastic composite membrane by vertical envelope, filler particles, horizontal sealing, printing lot number, notch cutting, rip cutting, beat operations such as geosutures, crosscut and finish particulate packing.
6.16 packing.
6.16.1 the folding description is with twice of the vertical doubling description of paper folder.
Accurately clearly print lot number and expiration date 6.16.2 print lot number at the lot number place of capsule.
6.16.3 cut bag.
Shrink film is cut into middle bag, specification: 25.0 * 19.5cm.
6.16.4 dress capsule.
Roll the capsule requirement well and rectify the four directions, six bags of medicines and a description are packed in the capsule, and respectively paste 19mm on the box both sides and seal and sign one.
6.16.5 plastic packaging.
In the bag, on the film sealing machine that contracts, seal then during 6 capsules are fitly put into, on the circulating shrink packaging machine of heat-sealing, seal.
6.16.6 after packing finishes, product is gone into the finished product Holding Area, please test, handle warehouse-in formality and warehouse-in after qualified.
Seven, description of drawings.
Be the technical process of more detailed description embodiment, the draw craft flow chart sees Figure of description for details.
Fig. 1: clear cloperastine breathes heavily granule pre-treating technology flow chart and the environmental area is divided.
Annotate:
1. in the frame of broken lines 300,000 grades of clean areas.
2. clean area is interior temperature: 18-26 ℃: relative humidity: 45-65%.
3. clean area and outdoor differential static pressure 〉=10Pa; Differential static pressure 〉=5Pa in the district between different brackets and district and the non-clean area.
4. each station illumination 〉=300Lux in distinguishing.
Fig. 2: clear cloperastine breathes heavily the granular preparation process chart and the environmental area is divided.
Annotate:
1. in the frame of broken lines 300,000 grades of clean areas.
2. clean area is interior temperature: 18-26 ℃; Relative humidity: 45-65%.
In the clean area with outdoor differential static pressure 〉=10Pa; Differential static pressure 〉=5Pa in the district between different brackets and district and the non-clean area.
4. each station illumination 〉=300Lux in distinguishing.
Claims (4)
1. the present invention is exploitation a kind of succession Chinese medicine ancient prescription " MAXINGSHIGAN TANG " elite, adopts modern crafts to make with extra care and forms; Clearly, change, a surname, logical and execute, with lung heat clearing expel the heat-evil, opening lung-energy, the turbid combination of Qinghua expectorant: cough-relieving, eliminate the phlegm, relieving asthma, antiinflammatory, antibacterial, strengthen cellular immunization and humoral immunization; Has reducing heat and dispersing lung-QI, the effect of relieving cough and asthma; Be used for acute bronchitis, acute episode of chronic bronchitis and belong to expectorant heat stagnation lung card, disease is seen: even cough pant, cough up phlegm yellow skin or not well, heating out of breath, pharyngalgia, dry stool, yellow fur or yellow greasy etc. pharmaceutical composition and preparation method thereof.Preparation method: get that Gypsum Fibrosum, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Herba Ephedrae (processing), Semen Armeniacae Amarum (processing), Bulbus Fritillariae Cirrhosae, Herba Ardisiae Japonicae, Folium Eriobotryae, Fructus Perillae (stir-fry), Radix Glycyrrhizae medical materials such as (processing) are selected, wash, cut medicine, drying, the process of preparing Chinese medicine, fragmentation, batching, extraction, separation, step such as concentrate and obtain clearly cloperastine and breathe heavily the granule extract powder; Get clearly cloperastine breathe heavily granule extract powder and sucrose, dextrin through wet granulation, drying, granulate, always mix, granule packing, packing promptly get granule.
2. according to the described a kind of drug regimen for the treatment of acute/chronic bronchitis of claim 1, it is characterized in that:
Ingredient of the present invention has: Gypsum Fibrosum, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Herba Ephedrae (processing), Semen Armeniacae Amarum (processing), Bulbus Fritillariae Cirrhosae, Herba Ardisiae Japonicae, Folium Eriobotryae, Fructus Perillae (stir-fry), Radix Glycyrrhizae (processing).
Pharmaceutical formulation of the present invention is formed the weight proportion scope: (10,000 bags).
Gypsum Fibrosum: 1-1000kg, Rhizoma Fagopyri Dibotryis: 1-1000kg, Herba Houttuyniae: 1-1000kg, Herba Ephedrae (processing): 1-1000kg, Semen Armeniacae Amarum (processing): 1-1000kg, Bulbus Fritillariae Cirrhosae: 1-1000kg, Herba Ardisiae Japonicae: 1-1000kg, Folium Eriobotryae: 1-1000kg, Fructus Perillae (stir-fry): 1-1000kg, Radix Glycyrrhizae (processing): 1-1000kg.
The solubilizing agent kind weight proportion scope that the present invention uses following one or more:
Binding agent: dextrin 1-30%, carboxymethyl cellulose 1-30%, gelatine size 1-30%, mucialga of arabic gummy 1-30%, sucrose 1-30%, lactose 1-30%;
Antiseptic: sodium benzoate 1-99%, Potassium Benzoate 1-99%, sorbic acid 1-99%, dehydroacetic acid 1-99%;
Correctives: sucrose 0.1-00kg, glucose 0.1-100kg, fructose 0.1-100kg, liquid glucose 1-99%;
Other classes: ethanol 1-99%.
3. method for making according to claim 2, its method for making is characterised in that: get that Gypsum Fibrosum, Rhizoma Fagopyri Dibotryis, Herba Houttuyniae, Herba Ephedrae (processing), Semen Armeniacae Amarum (processing), Bulbus Fritillariae Cirrhosae, Herba Ardisiae Japonicae, Folium Eriobotryae, Fructus Perillae (stir-fry), Radix Glycyrrhizae medical materials such as (processing) are selected, wash, cut medicine, drying, the process of preparing Chinese medicine, fragmentation, batching, extraction, separation, step such as concentrate and obtain clearly cloperastine and breathe heavily the granule extract powder; Get clearly cloperastine breathe heavily granule extract powder and sucrose, dextrin through wet granulation, drying, granulate, always mix, granule packing, packing promptly get granule.
4. method for making according to claim 1 is characterized in that as must a large amount of pharmacy increasing dose by above-mentioned formula proportion.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641412A (en) * | 2011-02-16 | 2012-08-22 | 辽宁中医药大学附属第二医院 | Root-securing and panting-calming granule and preparation process thereof |
| CN103405600A (en) * | 2013-07-08 | 2013-11-27 | 鲁奎 | Chinese medicine composition for treating asthma and preparation method thereof |
| CN108403922A (en) * | 2018-05-28 | 2018-08-17 | 长春雷允上药业有限公司 | The new application of clear cloperastine asthma particle |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998791A (en) * | 2006-12-26 | 2007-07-18 | 章丽美 | Oral traditional Chinese medicine for treating asthmatic acute bronchitis |
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2008
- 2008-08-19 CN CN2008100510920A patent/CN101653542B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641412A (en) * | 2011-02-16 | 2012-08-22 | 辽宁中医药大学附属第二医院 | Root-securing and panting-calming granule and preparation process thereof |
| CN103405600A (en) * | 2013-07-08 | 2013-11-27 | 鲁奎 | Chinese medicine composition for treating asthma and preparation method thereof |
| CN108403922A (en) * | 2018-05-28 | 2018-08-17 | 长春雷允上药业有限公司 | The new application of clear cloperastine asthma particle |
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| CN101653542B (en) | 2011-07-13 |
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Address after: 130012 Changchun, Jilin City, the torch Road, No. 833 Patentee after: Changchun leiyunshang Pharmaceutical Co. Ltd. Address before: 130012 Changchun, Jilin City, the torch Road, No. 833 Patentee before: Changchun Yuanda Guoao Pharmaceutical Co., Ltd. |