CN104225206A - Sugar-free Changchun longevity granules and preparation method thereof - Google Patents
Sugar-free Changchun longevity granules and preparation method thereof Download PDFInfo
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Abstract
The invention provides sugar-free Changchun longevity granules and a preparation method thereof. The granules comprise radix asparagi, radix ophiopogonis, prepared rehmannia roots, Chinese yam, twotooth achyranthes roots, radix rehmanniae, folium cortex eucommiae, prepared fleeceflower roots, poria cocos, Chinese ginseng, radix aucklandiae, semen platycladi, fructus schizandrae, woodwardia japonica, wild pepper, acorus tatarinowii, grilled polygala roots, semen cuscutae, rosa laevigata michx, fructus lycii, fructus rubi, cortex lycii radicis, rhizoma alismatis powder and a corrigent. The preparation method comprises the following steps: firstly, extracting radix asparagi, radix ophiopogonis, prepared rehmannia roots, Chinese yam, twotooth achyranthes roots, radix rehmanniae, folium cortex eucommiae, prepared fleeceflower roots, poria cocos, Chinese ginseng, radix aucklandiae, semen platycladi, fructus schizandrae, woodwardia japonica, wild pepper, acorus tatarinowii, grilled polygala roots, semen cuscutae, rosa laevigata michx, fructus lycii, fructus rubi, and cortex lycii radicis by using water, so that clear paste is obtained; then, mixing the clear paste, rhizoma alismatis powder and corrigent; and granulating and drying the obtained mixture. The granules prepared according to the method provided by the invention do not contain sugar, thereby enlarging the applicable people; the granules are simple in preparation process, controllable in quality, and convenient to take and carry; and the application amount of auxiliary materials is only 5% of that of a soft extract, so that the cost is greatly reduced.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of sugar-free Changchun and lengthen one's life granule and preparation method thereof.
Background technology
As the saying goes: " it's 40 day afternoon pasts people ", is say that it's 40 years old has past people, and every physiological function declines by containing to turn, each organ of health, and especially the function of the five internal organs organ and system just have dropped, failed, and generates the ability of QI and blood also along with weakening.Insufficiency of vital energy and blood unit god is gone out, insufficiency of vital energy and blood, human body has lacked the promotion of QI and blood and has moistened foster, and the decline of physiological function is naturally just faster.
Have and mend clearly beidirectional Changchun and to lengthen one's life cream, side is loaded in " Guangxi Ci Xi hospital choosing view ", original name " Changchun lengthen one's life pellet ", after be embodied in " the Sanitation Ministry medicine standard " Traditional Chinese medicine historical preparation the 19, the party has tonifying five ZANG-organs, regulate yin-yang, replenishing QI and blood, strengthening bone and muscle effect.Easily tired to body void, senilism is forgetful, and palpitation and insomnia is had a dizzy spell, and the diseases such as soreness of the waist and knees have good curative effect.
In recent years due to the impact by the factor such as environment, diet, " three-hypers " crowds such as hyperglycemia, hyperlipidemia, hypertension present ascendant trend year by year, and they all require low sugar and low fat in diet and medication.And Changchun lengthens one's life cream as soft extract, add refined honey or sugar is made, sugar content reaches more than 70%, limits the use of three-hypers crowd, and soft extract carries and take equal inconvenience, and the popularization of this product is restricted.
Chinese medicine granules refers to extract and the proper auxiliary materials of Chinese crude drug or mixes with part fine medicinal material powder, the dry graininess dosage form made.Chinese medicine granules is a kind of form of Chinese drug developed in conjunction with the feature of decoction, medicated wine and syrup, both maintain decoction and absorb fast, effective feature rapidly, overcome again before decoction is taken and decoct temporarily, be long placed in and easily mouldly lose rotten feature, the not shortcoming of Portable belt, possess soluble, easily absorb, bioavailability is better than tablet, preparation technology is fewer than tablet, injection again, so granule development is very fast, and a dark class novel form by Clinical practice.Alternatively Chinese medicine granules is prepared slices of Chinese crude drugs Processing methods technique and form improvement progress of research, be according to Chinese medical theory clinical practice needs, and Chinese crude drug and tcm and herbal slice carried out to a kind of novel form increased evident in efficacy being easy to carry and taking of special processing.Start to come across the seventies in last century, because it carries taking convenience, once with the speed development increasing progressively 41.9% year in the Chinese medicine manufacture of the eighties in last century.Chinese medicine granules is many containing fine medicinal material powder at first, technique is determined by rule of thumb, along with the raising that the quality of the pharmaceutical preparations requires, the application of various new adjuvant and new equipment, new technique, the technique of Chinese medicine granules has a great development, now to the future development of Chinese medicinal granule, simultaneously also also there is regulation definitely to the content of the effective ingredient of Chinese medicinal granule, more can ensure the quality of products and drug safety.
Summary of the invention
The object of this invention is to provide a kind of sugar-free Changchun to lengthen one's life granule and preparation method thereof, this granule, not containing multitudinous sugar, is applicable to hyperglycemia, hyperlipemic patients takes, expand applicable crowd; Processing technology is simple, quality controllable, and take, carry more convenient, supplementary product consumption is only 5% of soft extract, has greatly saved cost.
Sugar-free Changchun lengthens one's life granule, comprise with parts by weight: Radix Asparagi 2 ~ 4 parts, Radix Ophiopogonis 2 ~ 4 parts, Radix Rehmanniae Preparata 2 ~ 4 parts, Rhizoma Dioscoreae 2 ~ 4 parts, Radix Achyranthis Bidentatae 2 ~ 4 parts, Radix Rehmanniae 2 ~ 4 parts, Folium Eucommiae 2 ~ 4 parts, Radix Polygoni Multiflori Preparata 2 ~ 4 parts, 2 ~ 4 parts, Poria, Radix Ginseng 1 ~ 2 part, the Radix Aucklandiae 2 ~ 4 parts, Semen Platycladi 2 ~ 4 parts, Fructus Schisandrae Chinensis 2 ~ 4 parts, Rhizoma Cibotii 2 ~ 4 parts, 1 ~ 2 part, Pericarpium Zanthoxyli, Rhizoma Acori Graminei 1 ~ 2 part, Radix Polygalae (processing) 1 ~ 2 part, Semen Cuscutae 4 ~ 6 parts, Fructus Rosae Laevigatae 4 ~ 6 parts, Fructus Lycii 1.5 ~ 2 parts, Fructus Rubi 1.5 ~ 2 parts, Cortex Lycii 1.5 ~ 2 parts, Rhizoma Alismatis powder 1 ~ 2 part, correctives 1 ~ 2 part.
As the further improvement of foregoing invention, described correctives is lactose or aspartame.
As the further improvement of foregoing invention, the granularity of described correctives is 80 ~ 120 orders.
As the further improvement of foregoing invention, the granularity of described Rhizoma Alismatis powder is 80 ~ 100 orders.
Granule of the present invention in the preparation, according to the characteristic of medical material, is directly used as medicine, simultaneously as adjuvant excipient after selecting starch-containing Rhizoma Alismatis that is more, that be easy to pulverize to pulverize; Use lactose and protein sugar as adjuvant, not containing multitudinous sugar, applicable hyperglycemia, hyperlipemic patients are taken.
Above-mentioned sugar-free Changchun lengthens one's life the preparation method of granule, comprises the following steps:
Step 1, by Radix Asparagi, Radix Ophiopogonis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Rehmanniae, Folium Eucommiae, Radix Polygoni Multiflori Preparata, Poria, Radix Ginseng, the Radix Aucklandiae, Semen Platycladi, Fructus Schisandrae Chinensis, Rhizoma Cibotii, Pericarpium Zanthoxyli, Rhizoma Acori Graminei, Radix Polygalae (processing), Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Lycii, Fructus Rubi, Cortex Lycii 22 taste medicine, add 8 times of water gagings respectively, 6 times of water gagings, 5 times amount soak by water three times, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste I of 80 DEG C of mother-in-law U.S. degree Be=4 °, leave standstill 24 hours, get supernatant, be condensed into the clear paste II that 80 DEG C of relative densities are 1.21 ~ 1.25,
Step 2, mixes step 1 gained clear paste II with Rhizoma Alismatis powder, correctives, and granulation, drying, to obtain final product.
As the further improvement of foregoing invention, in step 1, first reconcentration after the acidify of clear paste I gained supernatant, filtration is obtained clear paste II.
As the further improvement of foregoing invention, the method for described acidify adds carbon dioxide.
The every packed amount of gained granule of the present invention is 15g, and every gram of granule must not be less than 0.02mg containing Radix Polygoni Multiflori Preparata in stilbene glucoside.
Sugar-free Changchun of the present invention lengthens one's life granule not containing multitudinous sugar, and applicable hyperglycemia, hyperlipemic patients are taken, and expand applicable crowd; Processing technology is simple, quality controllable, and take, carry more convenient, supplementary product consumption is only 5% of soft extract, has greatly saved cost.
Detailed description of the invention
Embodiment 1
Sugar-free Changchun lengthens one's life granule, comprises: Radix Asparagi 2 parts, Radix Ophiopogonis 2 parts, Radix Rehmanniae Preparata 2 parts, Rhizoma Dioscoreae 2 parts with parts by weight, Radix Achyranthis Bidentatae 2 parts, Radix Rehmanniae 2 parts, Folium Eucommiae 2 parts, Radix Polygoni Multiflori Preparata 2 parts, 2 parts, Poria, Radix Ginseng 1 part, the Radix Aucklandiae 2 parts, Semen Platycladi 2 parts, Fructus Schisandrae Chinensis 2 parts, Rhizoma Cibotii 2 parts, 1 part, Pericarpium Zanthoxyli, Rhizoma Acori Graminei 1 part, Radix Polygalae (processing) 1 part, Semen Cuscutae 4 parts, Fructus Rosae Laevigatae 4 parts, Fructus Lycii 1.5 parts, Fructus Rubi 1.5 parts, Cortex Lycii 1.5 parts, Rhizoma Alismatis powder 1 part, correctives 1 part.
Above-mentioned correctives is lactose, and the granularity of lactose is respectively 60 orders, 80 orders, 100 orders, 120 orders, 200 orders.
The granularity of above-mentioned Rhizoma Alismatis powder is 80 orders.
Above-mentioned sugar-free Changchun lengthens one's life the preparation method of granule, comprises the following steps:
Step 1, by Radix Asparagi, Radix Ophiopogonis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Rehmanniae, Folium Eucommiae, Radix Polygoni Multiflori Preparata, Poria, Radix Ginseng, the Radix Aucklandiae, Semen Platycladi, Fructus Schisandrae Chinensis, Rhizoma Cibotii, Pericarpium Zanthoxyli, Rhizoma Acori Graminei, Radix Polygalae (processing), Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Lycii, Fructus Rubi, Cortex Lycii 22 taste medicine, add 8 times of water gagings respectively, 6 times of water gagings, 5 times amount soak by water three times, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste I of 80 DEG C of mother-in-law U.S. degree Be=4 °, leave standstill 24 hours, get supernatant, be condensed into the clear paste II that 80 DEG C of relative densities are 1.21 ~ 1.25,
Step 2, mixes step 1 gained clear paste II with Rhizoma Alismatis powder, correctives, and granulation, drying, to obtain final product.
Gained granule Performance:
(1) granulate and dissolving situation: detect by " Chinese Pharmacopoeia " dissolubility about granule, observe dissolving situation.
(2) mouldability test: gained granule 80% is between 15 ~ 60 orders, and for mouldability is general, the granule of granularity between 15 ~ 28 orders, more than 50%, is good moldability.
(3) hygroscopicity experiment: solution bottom being filled saturated KCl places 1 day, make its inner RH constant in 84%, 0.5g gained granule is put into bottom the weighing botle of dry constant weight, at the bottom of being laid in bottle, weigh and be dried to constant weight, precise weighing is placed in the exsiccator of RH=84% and (opens and weigh bottle cap), and timing is weighed and calculates Moisture percentage.
As can be known from the above table, employing 80 ~ 120 order lactose, made grain forming is better, and the rear nothing of dissolving precipitates and intragranular disintegration speed is fast.
Embodiment 2
Sugar-free Changchun lengthens one's life granule, comprises: Radix Asparagi 2 parts, Radix Ophiopogonis 2 parts, Radix Rehmanniae Preparata 2 parts, Rhizoma Dioscoreae 2 parts with parts by weight, Radix Achyranthis Bidentatae 2 parts, Radix Rehmanniae 2 parts, Folium Eucommiae 2 parts, Radix Polygoni Multiflori Preparata 2 parts, 2 parts, Poria, Radix Ginseng 1 part, the Radix Aucklandiae 2 parts, Semen Platycladi 2 parts, Fructus Schisandrae Chinensis 2 parts, Rhizoma Cibotii 2 parts, 1 part, Pericarpium Zanthoxyli, Rhizoma Acori Graminei 1 part, Radix Polygalae (processing) 1 part, Semen Cuscutae 4 parts, Fructus Rosae Laevigatae 4 parts, Fructus Lycii 1.5 parts, Fructus Rubi 1.5 parts, Cortex Lycii 1.5 parts, Rhizoma Alismatis powder 1 part, correctives 1 part.
Above-mentioned correctives is lactose, and the granularity of lactose is respectively 100 orders.
The granularity of above-mentioned Rhizoma Alismatis powder is 60 orders, 80 orders, 100 orders, 120 orders.
Above-mentioned sugar-free Changchun lengthens one's life the preparation method of granule, comprises the following steps:
Step 1, by Radix Asparagi, Radix Ophiopogonis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Rehmanniae, Folium Eucommiae, Radix Polygoni Multiflori Preparata, Poria, Radix Ginseng, the Radix Aucklandiae, Semen Platycladi, Fructus Schisandrae Chinensis, Rhizoma Cibotii, Pericarpium Zanthoxyli, Rhizoma Acori Graminei, Radix Polygalae (processing), Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Lycii, Fructus Rubi, Cortex Lycii 22 taste medicine, add 8 times of water gagings respectively, 6 times of water gagings, 5 times amount soak by water three times, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste I of 80 DEG C of mother-in-law U.S. degree Be=4 °, leave standstill 24 hours, get supernatant, be condensed into the clear paste II that 80 DEG C of relative densities are 1.21 ~ 1.25,
Step 2, mixes step 1 gained clear paste II with Rhizoma Alismatis powder, correctives, and granulation, drying, to obtain final product.
Gained granule Performance:
(1) granulate and dissolving situation: detect by " Chinese Pharmacopoeia " dissolubility about granule, observe dissolving situation.
(2) mouldability test: gained granule 80% is between 15 ~ 60 orders, and for mouldability is general, the granule of granularity between 15 ~ 28 orders, more than 50%, is good moldability.
(3) hygroscopicity experiment: solution bottom being filled saturated KCl places 1 day, make its inner RH constant in 84%, 0.5g gained granule is put into bottom the weighing botle of dry constant weight, at the bottom of being laid in bottle, weigh and be dried to constant weight, precise weighing is placed in the exsiccator of RH=84% and (opens and weigh bottle cap), and timing is weighed and calculates Moisture percentage.
As can be known from the above table, adopt 80 ~ 100 order Rhizoma Alismatis powder, made granule humidity-proof ability, dissolubility and granulation situation are all better.
Embodiment 3
Sugar-free Changchun lengthens one's life granule, comprises: Radix Asparagi 3 parts, Radix Ophiopogonis 3 parts, Radix Rehmanniae Preparata 3 parts, Rhizoma Dioscoreae 3 parts with parts by weight, Radix Achyranthis Bidentatae 3 parts, Radix Rehmanniae 3 parts, Folium Eucommiae 3 parts, Radix Polygoni Multiflori Preparata 3 parts, 3 parts, Poria, Radix Ginseng 1.5 parts, the Radix Aucklandiae 3 parts, Semen Platycladi 3 parts, Fructus Schisandrae Chinensis 3 parts, Rhizoma Cibotii 3 parts, 1.5 parts, Pericarpium Zanthoxyli, Rhizoma Acori Graminei 1.5 parts, Radix Polygalae (processing) 1.5 parts, Semen Cuscutae 5 parts, Fructus Rosae Laevigatae 5 parts, Fructus Lycii 1.8 parts, Fructus Rubi 1.8 parts, Cortex Lycii 1.8 parts, Rhizoma Alismatis powder 1.2 parts, correctives 1.5 parts.
Above-mentioned correctives is aspartame, and the granularity of aspartame is 100 orders.
The granularity of above-mentioned Rhizoma Alismatis powder is 100 orders.
Above-mentioned sugar-free Changchun lengthens one's life the preparation method of granule, comprises the following steps:
Step 1, by Radix Asparagi, Radix Ophiopogonis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Rehmanniae, Folium Eucommiae, Radix Polygoni Multiflori Preparata, Poria, Radix Ginseng, the Radix Aucklandiae, Semen Platycladi, Fructus Schisandrae Chinensis, Rhizoma Cibotii, Pericarpium Zanthoxyli, Rhizoma Acori Graminei, Radix Polygalae (processing), Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Lycii, Fructus Rubi, Cortex Lycii 22 taste medicine, add 8 times of water gagings respectively, 6 times of water gagings, 5 times amount soak by water three times, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste I of 80 DEG C of mother-in-law U.S. degree Be=4 °, leave standstill 24 hours, get supernatant, be condensed into the clear paste II that 80 DEG C of relative densities are 1.21 ~ 1.25,
Step 2, mixes step 1 gained clear paste II with Rhizoma Alismatis powder, correctives, and granulation, drying, to obtain final product.
The present embodiment gained granule mouldability is better, and the rear nothing of dissolving precipitates and intragranular disintegration speed is fast; In stilbene glucoside every gram granule containing Radix Polygoni Multiflori Preparata 0.035mg.
Embodiment 4
The difference of the present embodiment and embodiment 3 is: do not pulverized by Rhizoma Alismatis, and Rhizoma Alismatis is extracted together with other Chinese medicinal components, specific as follows:
Sugar-free Changchun lengthens one's life granule, comprises: Radix Asparagi 3 parts, Radix Ophiopogonis 3 parts, Radix Rehmanniae Preparata 3 parts, Rhizoma Dioscoreae 3 parts with parts by weight, Radix Achyranthis Bidentatae 3 parts, Radix Rehmanniae 3 parts, Folium Eucommiae 3 parts, Radix Polygoni Multiflori Preparata 3 parts, 3 parts, Poria, Radix Ginseng 1.5 parts, the Radix Aucklandiae 3 parts, Semen Platycladi 3 parts, Fructus Schisandrae Chinensis 3 parts, Rhizoma Cibotii 3 parts, 1.5 parts, Pericarpium Zanthoxyli, Rhizoma Acori Graminei 1.5 parts, Radix Polygalae (processing) 1.5 parts, Semen Cuscutae 5 parts, Fructus Rosae Laevigatae 5 parts, Fructus Lycii 1.8 parts, Fructus Rubi 1.8 parts, Cortex Lycii 1.8 parts, Rhizoma Alismatis 1.2 parts, correctives 1.5 parts.
Above-mentioned correctives is aspartame, and the granularity of aspartame is 100 orders.
Above-mentioned sugar-free Changchun lengthens one's life the preparation method of granule, comprises the following steps:
Step 1, by Radix Asparagi, Radix Ophiopogonis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Rehmanniae, Folium Eucommiae, Radix Polygoni Multiflori Preparata, Poria, Radix Ginseng, the Radix Aucklandiae, Semen Platycladi, Fructus Schisandrae Chinensis, Rhizoma Cibotii, Pericarpium Zanthoxyli, Rhizoma Acori Graminei, Radix Polygalae (processing), Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Lycii, Fructus Rubi, Cortex Lycii, Rhizoma Alismatis 23 taste medicine, add 8 times of water gagings respectively, 6 times of water gagings, 5 times amount soak by water three times, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste I of 80 DEG C of mother-in-law U.S. degree Be=4 °, leave standstill 24 hours, get supernatant, be condensed into the clear paste II that 80 DEG C of relative densities are 1.21 ~ 1.25,
Step 2, mixes step 1 gained clear paste II with correctives, and granulation, drying, to obtain final product.
The present embodiment gained granule soft material granulation is more sticky, not easily sieves, and obtained grain graininess is less, comparatively hard, dissolves soon, standing sheet is carved with precipitation and intragranular disintegration speed is slow; In stilbene glucoside every gram granule containing Radix Polygoni Multiflori Preparata 0.028mg.
In the present embodiment, Rhizoma Alismatis and other Chinese medicinal components are together extracted as clear paste, make to lack excipient in granule, cause that granulation situation is poor, dissolubility is bad.
Embodiment 5
The present embodiment is with the difference of embodiment 3: the supernatant of step 1 gained clear paste I through titanium dioxide acidify, filter after reconcentration become clear paste II, specific as follows:
Sugar-free Changchun lengthens one's life granule, comprises: Radix Asparagi 3 parts, Radix Ophiopogonis 3 parts, Radix Rehmanniae Preparata 3 parts, Rhizoma Dioscoreae 3 parts with parts by weight, Radix Achyranthis Bidentatae 3 parts, Radix Rehmanniae 3 parts, Folium Eucommiae 3 parts, Radix Polygoni Multiflori Preparata 3 parts, 3 parts, Poria, Radix Ginseng 1.5 parts, the Radix Aucklandiae 3 parts, Semen Platycladi 3 parts, Fructus Schisandrae Chinensis 3 parts, Rhizoma Cibotii 3 parts, 1.5 parts, Pericarpium Zanthoxyli, Rhizoma Acori Graminei 1.5 parts, Radix Polygalae (processing) 1.5 parts, Semen Cuscutae 5 parts, Fructus Rosae Laevigatae 5 parts, Fructus Lycii 1.8 parts, Fructus Rubi 1.8 parts, Cortex Lycii 1.8 parts, Rhizoma Alismatis powder 1.2 parts, correctives 1.5 parts.
Above-mentioned correctives is aspartame, and the granularity of aspartame is 100 orders.
The granularity of above-mentioned Rhizoma Alismatis powder is 100 orders.
Above-mentioned sugar-free Changchun lengthens one's life the preparation method of granule, comprises the following steps:
Step 1, by Radix Asparagi, Radix Ophiopogonis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Rehmanniae, Folium Eucommiae, Radix Polygoni Multiflori Preparata, Poria, Radix Ginseng, the Radix Aucklandiae, Semen Platycladi, Fructus Schisandrae Chinensis, Rhizoma Cibotii, Pericarpium Zanthoxyli, Rhizoma Acori Graminei, Radix Polygalae (processing), Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Lycii, Fructus Rubi, Cortex Lycii 22 taste medicine, add 8 times of water gagings respectively, 6 times of water gagings, 5 times amount soak by water three times, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste I of 80 DEG C of mother-in-law U.S. degree Be=4 °, leave standstill 24 hours, get supernatant, after carbon dioxide acidify, be the ultrafiltration membrance filter of 200kDa with molecular cut off, penetrating fluid is condensed into the clear paste II that 80 DEG C of relative densities are 1.21 ~ 1.25,
Step 2, mixes step 1 gained clear paste II with Rhizoma Alismatis powder, correctives, and granulation, drying, to obtain final product.
The present embodiment gained granule mouldability is better, and the rear nothing of dissolving precipitates and intragranular disintegration speed is fast; In stilbene glucoside every gram granule containing Radix Polygoni Multiflori Preparata 0.055mg.
The present embodiment, by the supernatant of step 1 gained clear paste I reconcentration after carbon dioxide acidify, filtration, makes stilbene glucoside content in granule improve.This may be because after supernatant acidify, the albuminous degeneration in solution, reunion, and granule becomes large, is more easily filtered removal, the content of effective ingredient in limited raising clear paste II, and active constituent content in granule is improved.
Attached:
The HPLC detection method of stilbene glucoside in Radix Polygoni Multiflori
The preparation of reference substance
Precision takes stilbene glucoside reference substance 5.00mg, is placed in the brown volumetric flask of 25ml, adds Diluted Alcohol solubilize and standardize solution, obtains 0.2mg/ml stilbene glucoside solution.
The preparation of need testing solution
Precision takes sugar-free Changchun and to lengthen one's life particulate samples powder (cross No. four sieves) 0.2g, put in conical flask, precision adds Diluted Alcohol 25ml, stable weight, 80 DEG C of water-baths backflow 30min, stable weight again after cooling, the weight of less loss is supplied with Diluted Alcohol, shake up, leave standstill, get supernatant subsequent filtrate (0.45 μm of filter membrane) and get final product.
Chromatographic condition
Hypersil ODS chromatographic column (200mm × 4.6mm × 1.5 μm), mobile phase: acetonitrile-water (20:80), determined wavelength: 320nm, flow velocity: 1.0ml/min, column temperature: 15 DEG C, sample size: 10 μ l, signals collecting: 15min, other: test sample keeps in Dark Place, sample introduction.
Claims (7)
1. sugar-free Changchun lengthens one's life granule, it is characterized in that: comprise following component as raw material using parts by weight: Radix Asparagi 2 ~ 4 parts, Radix Ophiopogonis 2 ~ 4 parts, Radix Rehmanniae Preparata 2 ~ 4 parts, Rhizoma Dioscoreae 2 ~ 4 parts, Radix Achyranthis Bidentatae 2 ~ 4 parts, Radix Rehmanniae 2 ~ 4 parts, Folium Eucommiae 2 ~ 4 parts, Radix Polygoni Multiflori Preparata 2 ~ 4 parts, 2 ~ 4 parts, Poria, Radix Ginseng 1 ~ 2 part, the Radix Aucklandiae 2 ~ 4 parts, Semen Platycladi 2 ~ 4 parts, Fructus Schisandrae Chinensis 2 ~ 4 parts, Rhizoma Cibotii 2 ~ 4 parts, 1 ~ 2 part, Pericarpium Zanthoxyli, Rhizoma Acori Graminei 1 ~ 2 part, Cortex et Radix Polygalae (processed) 1 ~ 2 part, Semen Cuscutae 4 ~ 6 parts, Fructus Rosae Laevigatae 4 ~ 6 parts, Fructus Lycii 1.5 ~ 2 parts, Fructus Rubi 1.5 ~ 2 parts, Cortex Lycii 1.5 ~ 2 parts, Rhizoma Alismatis powder 1 ~ 2 part, correctives 1 ~ 2 part.
2. sugar-free Changchun according to claim 1 lengthens one's life granule, it is characterized in that: described correctives is lactose or aspartame.
3. sugar-free Changchun according to claim 1 lengthens one's life granule, it is characterized in that: the granularity of described correctives is 80 ~ 120 orders.
4. sugar-free Changchun according to claim 1 lengthens one's life granule, it is characterized in that: the granularity of described Rhizoma Alismatis powder is 80 ~ 100 orders.
5. the sugar-free Changchun according to any one of Claims 1-4 lengthens one's life the preparation method of granule, it is characterized in that: comprise the following steps:
Step 1, by Radix Asparagi, Radix Ophiopogonis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Radix Achyranthis Bidentatae, Radix Rehmanniae, Folium Eucommiae, Radix Polygoni Multiflori Preparata, Poria, Radix Ginseng, the Radix Aucklandiae, Semen Platycladi, Fructus Schisandrae Chinensis, Rhizoma Cibotii, Pericarpium Zanthoxyli, Rhizoma Acori Graminei, Radix Polygalae (processing), Semen Cuscutae, Fructus Rosae Laevigatae, Fructus Lycii, Fructus Rubi, Cortex Lycii 22 taste medicine, add 8 times of water gagings, 6 times of water gagings, 5 times amount soak by water three times respectively, each 3 hours, collecting decoction, filter, filtrate is condensed into the clear paste I of 80 DEG C of mother-in-law U.S. degree Be=4 °, leave standstill 24 hours, get supernatant, be condensed into the clear paste II that 80 DEG C of relative densities are 1.21 ~ 1.25;
Step 2, mixes step 1 gained clear paste II with Rhizoma Alismatis powder, correctives, and granulation, drying, to obtain final product.
6. sugar-free Changchun according to claim 5 lengthens one's life the preparation method of granule, it is characterized in that: in step 1 first by the acidify of clear paste I gained supernatant, filter after reconcentration obtain clear paste II.
7. sugar-free Changchun according to claim 6 lengthens one's life the preparation method of granule, it is characterized in that: the method for described acidify adds carbon dioxide.
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| CN201410353550.1A CN104225206A (en) | 2014-07-23 | 2014-07-23 | Sugar-free Changchun longevity granules and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106226449A (en) * | 2016-07-20 | 2016-12-14 | 江苏七O七天然制药有限公司 | A kind of Changchun lengthens one's life the quality determining method of cream |
| CN108607039A (en) * | 2018-05-10 | 2018-10-02 | 湖南康尔佳制药股份有限公司 | A kind of compound kidney-reinforcing medicinal liquor and preparation method thereof |
| CN110870897A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Cortex lycii radicis formula particle and preparation method and application thereof |
| CN112402551A (en) * | 2020-11-30 | 2021-02-26 | 江苏七○七天然制药有限公司 | Changchun life-prolonging capsule and its preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537545A (en) * | 2003-04-15 | 2004-10-20 | 安徽省医学科学研究所 | Sugar-free type blood-fat-lowering granule, and its prepn. method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1537545A (en) * | 2003-04-15 | 2004-10-20 | 安徽省医学科学研究所 | Sugar-free type blood-fat-lowering granule, and its prepn. method |
Non-Patent Citations (1)
| Title |
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| 王旭东: "《中国进补大全》", 31 August 2011, 上海科学技术出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106226449A (en) * | 2016-07-20 | 2016-12-14 | 江苏七O七天然制药有限公司 | A kind of Changchun lengthens one's life the quality determining method of cream |
| CN108607039A (en) * | 2018-05-10 | 2018-10-02 | 湖南康尔佳制药股份有限公司 | A kind of compound kidney-reinforcing medicinal liquor and preparation method thereof |
| CN110870897A (en) * | 2018-08-30 | 2020-03-10 | 湖北香连药业有限责任公司 | Cortex lycii radicis formula particle and preparation method and application thereof |
| CN110870897B (en) * | 2018-08-30 | 2022-03-25 | 湖北香连药业有限责任公司 | Preparation method of cortex lycii radicis formula particles |
| CN112402551A (en) * | 2020-11-30 | 2021-02-26 | 江苏七○七天然制药有限公司 | Changchun life-prolonging capsule and its preparation method |
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Application publication date: 20141224 |