CN112402551A - Changchun life-prolonging capsule and its preparation method - Google Patents

Changchun life-prolonging capsule and its preparation method Download PDF

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CN112402551A
CN112402551A CN202011377013.2A CN202011377013A CN112402551A CN 112402551 A CN112402551 A CN 112402551A CN 202011377013 A CN202011377013 A CN 202011377013A CN 112402551 A CN112402551 A CN 112402551A
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ginseng
mixing
radix
ginseng radix
prepared
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周园
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Jiangsu 707 Natural Pharmaceutical Co ltd
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Jiangsu 707 Natural Pharmaceutical Co ltd
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract

The invention provides a capsule for prolonging life and a preparation method thereof, and the preparation method of the capsule comprises the following steps: firstly, grinding ginseng into fine powder for later use; extracting the rest Ginseng radix with ethanol under reflux for three times, filtering, collecting Ginseng radix residue, recovering ethanol, mixing filtrates, and concentrating to obtain Ginseng radix concentrated solution; decocting the Ginseng radix residue and other medicinal materials in water for three times, mixing decoctions, filtering, mixing with Ginseng radix concentrated solution, concentrating into soft extract, spray drying into fine powder, mixing with Ginseng radix fine powder, granulating with fluidized bed, mixing, encapsulating, and packaging. The Changchun Yishou capsule prepared by the invention meets the requirements on properties, identification, water content, loading difference, disintegration time limit and microbial limit, has accurate medicine content, can accurately control the taking dosage, has stable quality, is convenient and quick to take, is convenient to store and transport, and is suitable for symptoms such as weakness, easy fatigue, palpitation, insomnia, dizziness, soreness and weakness of waist and knees and the like.

Description

Changchun life-prolonging capsule and its preparation method
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a Changchun life-prolonging capsule and a preparation method thereof.
Background
The Changchun longevity cream produced by Jiangsu Qio seven natural pharmacy limited company has better curative effect as a Chinese patent medicine for tonifying qi and enriching blood, conditioning the five internal organs and strengthening the muscles and bones, and the prescription and the preparation method thereof are disclosed in the medicine standard of the Ministry of health (the 19 th volume of Chinese patent medicine finished product preparation) as follows:
prescription: 100g of radix asparagi, 100g of radix ophiopogonis, 100g of prepared rehmannia root, 100g of Chinese yam, 100g of achyranthes root, 100g of eucommia leaf, 100g of prepared fleece-flower root, 50g of ginseng, 100g of tuckahoe, 100g of costustoot, 100g of platycladi seed, 100g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 50g of rhizoma alismatis, 50g of rhizoma acori graminei, 50g of polygala root (roasted), 200g of semen cuscutae, 200g of cherokee rose fruit, 75g of medlar, 75g of raspberry and 75g of cortex lycii radicis; the preparation method comprises the following steps: decocting the twenty three medicines with water for three times, wherein the first time is 4 hours, and the second time and the third time are 3 hours respectively, combining the decoctions, filtering, standing for 24 hours, taking the supernatant fluid to concentrate into clear paste with the relative density of 1.21-1.25 (80-85 ℃), taking sucrose with the amount of 4 times of the clear paste in addition, heating to dissolve, filtering, combining with the clear paste, mixing uniformly, and concentrating to the specified concentration to obtain the traditional Chinese medicine.
The existing dosage form is a decocted ointment, the quality stability of the prepared product needs to be improved, the medicine content is not accurate enough, the storage and the transportation are not easy, the carrying and the taking of a patient are inconvenient, and the curative effect can not be ensured.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the Changchun capsule for prolonging life and the preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a capsule for prolonging life is prepared from the following components in parts by weight: 50-150g of asparagus, 100-100 g of dwarf lilyturf root, 50-100g of prepared rehmannia root, 100-200g of Chinese yam, 100-200g of achyranthes root, 50-100g of rehmannia root, 100-200g of eucommia leaf, 50-150g of prepared fleece-flower root, 100-200g of tuckahoe, 100-200g of ginseng, 100-200g of costustoot, 100-200g of platycladi seed, 100-200g of schisandra fruit, 100-200g of east Asian tree fern rhizome, 50-100g of pepper, 50-100g of oriental waterplantain rhizome, 50-100g of grassleaf sweelflag rhizome, 50-100g of polygala root (tenuifolia), 100-200g of dodder, 150-250g of cherokee rose fruit, 75-150g of medlar, 75-150g of raspberry and 75-150g of cortex lycii radicis.
Further, the Changchun longevity capsule is preferably prepared from the following components in parts by weight: 50-100g of radix asparagi, 100g of radix ophiopogonis, 120g of prepared rehmannia root, 100g of Chinese yam, 100g of radix achyranthis bidentatae, 50-75g of rehmannia root, 100g of eucommia bark leaf, 75g of prepared fleece-flower root, 100g of tuckahoe, 150g of ginseng, 100g of elecampane, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 50-75g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 100g of semen cuscutae, 125g of cherokee rose, 200g of fructus lycii, 75-100g of raspberry and 100g of cortex lycii radicis.
Further, the Changchun longevity capsule is preferably prepared from the following components in parts by weight: 50g of radix asparagi, 100g of radix ophiopogonis, 50g of prepared rehmannia root, 100g of Chinese yam, 100g of achyranthes bidentata, 50g of rehmannia root, 100g of eucommia ulmoides leaf, 75g of prepared fleece flower root, 100g of poria cocos, 150g of ginseng, 100g of costustoot, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 50g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 125g of semen cuscutae, 150g of cherokee rose fruit, 75g of medlar, 75g of raspberry and 100g of cortex.
The invention also provides a preparation method of the Changchun longevity capsule, which comprises the following steps:
(1) pulverizing 1/4-1/3 weight parts of Ginseng radix into fine powder;
(2) extracting the rest Ginseng radix with 70% -80% ethanol under reflux for three times, wherein the first time is 2-3 hr, and the second and third times are 2-3 hr respectively, filtering, collecting Ginseng radix residue, recovering ethanol, mixing filtrates, and concentrating to obtain Ginseng radix concentrated solution;
(3) decocting Ginseng radix residue and other materials in water for three times, each for 3-4 hr, mixing decoctions, filtering, mixing with Ginseng radix concentrated solution, concentrating to obtain fluid extract of 13-18 ° Be, spray drying to obtain fine powder, mixing with Ginseng radix fine powder, granulating with fluidized bed, mixing, encapsulating, and packaging.
Further, the weight of ginseng in the step (1) is preferably 3/10.
Further, the concentration of ethanol in the step (2) is preferably 70%; the time for the second and third times of ethanol reflux extraction is preferably 2-2.5 hours respectively.
Further, in the step (3), the ginseng filter residue and other medicinal materials are added with water and decocted for three times, and preferably, each time lasts for 3-3.5 hours; mixing the decoction with the Ginseng radix concentrated solution, and preferably concentrating to obtain fluid extract with a concentration of 15-18 ° Be.
The vinpocetine life prolonging capsule prepared by the invention has the specification: 0.32 g/granule, ginsenoside Rb as the main effective component of Ginseng radix1(C54H92O23) The quality is controlled by the content of ginsenoside Rb contained in each granule1(C54H92O23) It is not less than 0.10 mg.
Has the advantages that: the Changchun longevity capsule prepared by the invention has the following advantages: (1) the properties, identification, water content, loading difference, disintegration time limit and microbial limit all meet the requirements; (2) each granule contains ginsenoside Rb1(C54H92O23) The content is accurate and can accurately control the dosage, which is measured to be 0.13-0.16 mg; (3) after standing for 36 months, each granule contains ginsenoside Rb1(C54H92O23) The measured amount is not less than 0.12mg, and the quality is stable; (4) the adopted dosage form is capsule, can prevent the stimulation of the medicine to the gastric mucosa, is convenient and quick to take and convenient to store and transport.
Drawings
Fig. 1 is a preparation flow chart of the Changchun longevity capsule provided by the invention.
Wherein the following process must be completed in the clean zone (stage D): pulverizing Ginseng radix into fine powder; mixing the concentrated solution and the water decoction, spray drying, pulverizing, mixing, granulating, mixing, filling, and packaging.
Detailed Description
Example 1
A capsule for prolonging life is prepared from the following raw materials by weight: 50g of radix asparagi, 100g of radix ophiopogonis, 50g of prepared rehmannia root, 100g of Chinese yam, 100g of achyranthes bidentata, 50g of rehmannia root, 100g of eucommia ulmoides leaf, 75g of prepared fleece flower root, 100g of poria cocos, 150g of ginseng, 100g of costustoot, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 50g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 125g of semen cuscutae, 150g of cherokee rose fruit, 75g of medlar, 75g of raspberry and 100g of cortex.
The preparation method comprises the following steps:
(1) pulverizing 45g of Ginseng radix into fine powder;
(2) extracting the rest 105g of Ginseng radix with 70% ethanol under reflux for three times, wherein the first time is 3 hr, the second time and the third time are 2 hr respectively, filtering, collecting Ginseng radix residue, recovering ethanol, mixing filtrates, and concentrating to obtain Ginseng radix concentrated solution.
(3) Decocting Ginseng radix residue and other materials in water for three times, each for 3 hr, mixing decoctions, filtering, mixing with Ginseng radix concentrated solution, concentrating to obtain 16 ° Be fluid extract, spray drying to obtain fine powder, mixing with Ginseng radix fine powder, granulating with fluidized bed, mixing, encapsulating, and packaging.
The product content detection of the embodiment: each granule contains ginsenoside Rb1(C54H92O23) It was calculated to be 0.16 mg.
Example 2
A capsule for prolonging life is prepared from the following raw materials by weight: 50g of radix asparagi, 120g of radix ophiopogonis, 50g of prepared rehmannia root, 100g of Chinese yam, 100g of achyranthes bidentata, 75g of rehmannia root, 100g of folium cortex eucommiae, 75g of prepared fleece-flower root, 100g of poria cocos, 150g of ginseng, 100g of costustoot, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 50g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 125g of semen cuscutae, 150g of cherokee rose, 100g of wolfberry fruit, 75g of raspberry and 100.
The preparation method comprises the following steps:
(1) pulverizing 45g of Ginseng radix into fine powder;
(2) extracting the rest 105g of Ginseng radix with 70% ethanol under reflux for three times, wherein the first time is 2.5 hr, and the second and third times are 2.5 hr respectively, filtering, collecting Ginseng radix residue, recovering ethanol, mixing filtrates, and concentrating to obtain Ginseng radix concentrated solution.
(3) Decocting Ginseng radix residue and other materials in water for three times, each for 3 hr, mixing decoctions, filtering, mixing with Ginseng radix concentrated solution, concentrating to obtain 18 ° Be fluid extract, spray drying to obtain fine powder, mixing with Ginseng radix fine powder, granulating with fluidized bed, mixing, encapsulating, and packaging.
The product content detection of the embodiment: each granule contains ginsenoside Rb1(C54H92O23) It was calculated to be 0.14 mg.
Example 3
A capsule for prolonging life is prepared from the following raw materials by weight: 100g of radix asparagi, 100g of radix ophiopogonis, 50g of prepared rehmannia root, 100g of Chinese yam, 100g of achyranthes bidentata, 75g of rehmannia root, 100g of folium cortex eucommiae, 75g of prepared fleece-flower root, 100g of poria cocos, 150g of ginseng, 100g of elecampane, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 75g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 100g of semen cuscutae, 150g of cherokee rose, 100g of fructus lycii, 75g of raspberry and.
The preparation method comprises the following steps:
(1) pulverizing 45g of Ginseng radix into fine powder;
(2) extracting the rest 105g of Ginseng radix with 70% ethanol under reflux for three times, wherein the first time is 3 hr, the second time and the third time are 2 hr respectively, filtering, collecting Ginseng radix residue, recovering ethanol, mixing filtrates, and concentrating to obtain Ginseng radix concentrated solution.
(3) Decocting Ginseng radix residue and other materials in water for three times, each for 3.5 hr, mixing decoctions, filtering, mixing with Ginseng radix concentrated solution, concentrating to obtain fluid extract of 16 ° Be, spray drying to obtain fine powder, mixing with Ginseng radix fine powder, granulating with fluidized bed, mixing, encapsulating, and packaging.
The product content detection of the embodiment: each granule contains ginsenoside Rb1(C54H92O23) It was calculated to be 0.15 mg.
Example 4
A capsule for prolonging life is prepared from the following raw materials by weight: 75g of radix asparagi, 100g of radix ophiopogonis, 50g of prepared rehmannia root, 100g of Chinese yam, 100g of radix achyranthis bidentatae, 50g of rehmannia root, 150g of eucommia leaf, 75g of prepared fleece flower root, 100g of poria cocos, 150g of ginseng, 100g of elecampane, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 75g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 125g of semen cuscutae, 200g of cherokee rose, 75g of fructus lycii, 75g of raspberry and 100g of cortex.
The preparation method comprises the following steps:
(1) pulverizing 45g of Ginseng radix into fine powder;
(2) extracting the rest 105g of Ginseng radix with 70% ethanol under reflux for three times, wherein the first time is 2 hr, the second time and the third time are 2 hr respectively, filtering, collecting Ginseng radix residue, recovering ethanol, mixing filtrates, and concentrating to obtain Ginseng radix concentrated solution.
(3) Decocting Ginseng radix residue and other materials in water for three times, each for 3 hr, mixing decoctions, filtering, mixing with Ginseng radix concentrated solution, concentrating to obtain fluid extract of 15 ° Be, spray drying to obtain fine powder, mixing with Ginseng radix fine powder, granulating with fluidized bed, mixing, encapsulating, and packaging.
The product content detection of the embodiment: each granule contains ginsenoside Rb1(C54H92O23) It was calculated to be 0.13 mg.
The products of examples 1-4 were subjected to stability tests, the results of which are shown in tables 1-4:
table 1 example 1 product stability test results
Figure BDA0002807395970000051
Figure BDA0002807395970000061
Table 2 example 2 product stability test results
Figure BDA0002807395970000071
Figure BDA0002807395970000081
Table 3 example 3 product stability test results
Figure BDA0002807395970000091
Figure BDA0002807395970000101
Table 4 example 4 product stability test results
Figure BDA0002807395970000111
Figure BDA0002807395970000121
As shown in tables 1-4, the Changchun capsule for prolonging life prepared by the invention has the following advantages: (1) the properties, identification, water content, loading difference, disintegration time limit and microbial limit all meet the requirements; (2) each granule contains ginsenoside Rb1(C54H92O23) The content is accurate and can accurately control the dosage, which is measured to be 0.13-0.16 mg; (3) after standing for 36 months, each granule contains ginsenoside Rb1(C54H92O23) The total amount is not less than 0.12mg, and the quality is stable.

Claims (7)

1. A capsule for prolonging life and prolonging life is characterized in that: the composition is prepared from the following components in parts by weight: 50-150g of asparagus, 100-100 g of dwarf lilyturf root, 50-100g of prepared rehmannia root, 100-200g of Chinese yam, 100-200g of achyranthes root, 50-100g of rehmannia root, 100-200g of eucommia leaf, 50-150g of prepared fleece-flower root, 100-200g of tuckahoe, 100-200g of ginseng, 100-200g of costustoot, 100-200g of platycladi seed, 100-200g of schisandra fruit, 100-200g of east Asian tree fern rhizome, 50-100g of pepper, 50-100g of oriental waterplantain rhizome, 50-100g of grassleaf sweelflag rhizome, 50-100g of polygala root (tenuifolia), 100-200g of dodder, 150-250g of cherokee rose fruit, 75-150g of medlar, 75-150g of raspberry and 75-150g of cortex lycii radicis.
2. The vinca longevity-prolonging capsule according to claim 1, wherein: the composition is prepared from the following components in parts by weight: 50-100g of radix asparagi, 100g of radix ophiopogonis, 120g of prepared rehmannia root, 100g of Chinese yam, 100g of radix achyranthis bidentatae, 50-75g of rehmannia root, 100g of eucommia bark leaf, 75g of prepared fleece-flower root, 100g of tuckahoe, 150g of ginseng, 100g of elecampane, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 50-75g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 100g of semen cuscutae, 125g of cherokee rose, 200g of fructus lycii, 75-100g of raspberry and 100g of cortex lycii radicis.
3. The vinca longevity-prolonging capsule according to claim 2, wherein: the composition is prepared from the following components in parts by weight: 50g of radix asparagi, 100g of radix ophiopogonis, 50g of prepared rehmannia root, 100g of Chinese yam, 100g of achyranthes bidentata, 50g of rehmannia root, 100g of eucommia ulmoides leaf, 75g of prepared fleece flower root, 100g of poria cocos, 150g of ginseng, 100g of costustoot, 100g of platycladi seed, 150g of schisandra chinensis, 100g of rhizoma cibotii, 50g of pepper, 75g of rhizoma alismatis, 50g of rhizoma acori graminei, 50g of polygala tenuifolia (roasted), 125g of semen cuscutae, 150g of cherokee rose fruit, 75g of medlar, 75g of raspberry and 100g of cortex.
4. The method for preparing the Changchun Yishou capsule as claimed in any one of claims 1-3, which comprises the following steps: the method comprises the following steps:
(1) pulverizing 1/4-1/3 weight parts of Ginseng radix into fine powder;
(2) extracting the rest Ginseng radix with 70% -80% ethanol under reflux for three times, wherein the first time is 2-3 hr, and the second and third times are 2-3 hr respectively, filtering, collecting Ginseng radix residue, recovering ethanol, mixing filtrates, and concentrating to obtain Ginseng radix concentrated solution;
(3) decocting Ginseng radix residue and other materials in water for three times, each for 3-4 hr, mixing decoctions, filtering, mixing with Ginseng radix concentrated solution, concentrating to obtain fluid extract of 13-18 ° Be, spray drying to obtain fine powder, mixing with Ginseng radix fine powder, granulating with fluidized bed, mixing, encapsulating, and packaging.
5. The method for preparing Changchun longevity capsule according to claim 4, which is characterized in that: the weight of the ginseng in the step (1) is 3/10.
6. The method for preparing Changchun longevity capsule according to claim 4, which is characterized in that: the concentration of the ethanol in the step (2) is 70 percent; extracting with ethanol under reflux for 2-2.5 hr for the second and third times.
7. The method for preparing Changchun longevity capsule according to claim 4, which is characterized in that: in the step (3), the ginseng filter residue and other medicinal materials are added with water and decocted for three times, and each time lasts for 3-3.5 hours; mixing the decoction with the concentrated solution of Ginseng radix, and concentrating to obtain fluid extract of 15-18 ° Be.
CN202011377013.2A 2020-11-30 2020-11-30 Changchun life-prolonging capsule and its preparation method Pending CN112402551A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104225206A (en) * 2014-07-23 2014-12-24 江苏七O七天然制药有限公司 Sugar-free Changchun longevity granules and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN104225206A (en) * 2014-07-23 2014-12-24 江苏七O七天然制药有限公司 Sugar-free Changchun longevity granules and preparation method thereof

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