CN112933203A

CN112933203A - Traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function and preparation method of traditional Chinese medicine composition

Info

Publication number: CN112933203A
Application number: CN202011351341.5A
Authority: CN
Inventors: 刘显均
Original assignee: Sichuan Yehum Health Pharmacy Co ltd
Current assignee: Sichuan Yehum Health Pharmacy Co ltd
Priority date: 2020-11-26
Filing date: 2020-11-26
Publication date: 2021-06-11

Abstract

The invention discloses a traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function and a preparation method thereof, belongs to health-care nourishing medicinal liquor, and particularly relates to health-care nourishing wine prepared by taking concentrate extracted from cistanche as a main functional raw material. The active ingredient raw materials for preparing the health-care wine comprise cistanche, prepared rehmannia root, acanthopanax, leek seed, nameless fruit, schisandra fruit, myrobalan, fructus psoraleae, nandina, diaphragma juglandis, epimedium herb, clove, aconite, rhizoma cimicifugae, dried ginger, pepper, ginseng, dogwood, astragalus, rhizoma polygonati, lucid ganoderma, gastrodia elata, Chinese yam, poria cocos, tricholoma matsutake, medlar, mulberry, fructus alpiniae oxyphyllae, dried orange peel, cordyceps militaris, maca powder, lalang grass rhizome, liquorice, crystal sugar and pure grain white spirit. The invention has the advantages of accurate control of the prepared active ingredients, reasonable and scientific compatibility of the raw materials, simple and convenient preparation of wine tasting liquid, small deviation of the color of the finished product and convenient large-scale production. The product has health promotion effects of relieving fatigue and improving sexual function.

Description

Traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function and preparation method of traditional Chinese medicine composition

Technical Field

The invention relates to the field of health care wine, in particular to a traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function and a preparation method thereof.

Background

For thousands of years, the traditional Chinese medicine accumulates valuable experiences in the aspect of medicinal liquor and has rich contents. The nourishing and health-preserving effects of the medicinal liquor are known for a long time, but the traditional medicinal liquor is prepared by soaking single or multiple medicinal materials in liquor, and belongs to liquor preparation. The wine is prepared randomly according to the preference of a drinker, the compatibility of raw materials is lack of scientificity, the health care effect is difficult to play, and the requirements of people on the health care wine cannot be met. The traditional Chinese medicine treatment in China has a long history of improving impotence. The traditional Chinese medicine considers that the impotence in the middle-aged and young years is mainly caused by phlegm heat and blood stasis and liver depression, and the deficiency of the kidney is the secondary cause. Impotence in the elderly is mainly due to kidney deficiency and blood stasis, and is secondary to liver depression and phlegm-heat. The basic pathological change of impotence in traditional Chinese medicine is liver depression and kidney deficiency with damp-heat and blood stasis. However, the treatment of impotence should take the principles of syndrome differentiation followed by syndrome differentiation and the combination of disease differentiation and treatment based on syndrome differentiation, and the treatment effect can be improved only by organically combining the disease differentiation and treatment based on the syndrome differentiation. It is difficult to control the overall appearance of the disease only by differentiating syndromes and not differentiating diseases, so that the treatment is also difficult to obtain good effect. Therefore, there is a need to refine the cause or mechanism of impotence and correct and treat the cause or pathology with corresponding drugs to obtain a better therapeutic effect.

Disclosure of Invention

The traditional Chinese medicine composition has the effects of supplementing essence and producing sperm, has obvious curative effects on phlegm-heat liver depression type impotence and kidney deficiency and blood stasis type impotence, and has obvious improvement effects on symptoms such as soreness and weakness of waist and knees, dizziness and tinnitus, mental fatigue and hypodynamia, spermatorrhea and premature ejaculation, nocturia frequency, hypomnesis and the like caused by the kidney deficiency, and has obvious curative effects and small toxic and side effects. In addition, the preparation method of the traditional Chinese medicine composition has the advantages of easily available raw materials, simple steps and good repeatability.

To achieve the object of the present application, the present invention is achieved by the following means.

A traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function is prepared from the following traditional Chinese medicines in parts by weight:

15-25 parts of cistanche, 15-25 parts of prepared rehmannia root, 10-15 parts of acanthopanax, 5-8 parts of leek seed, 5-8 parts of nameless, 15-20 parts of schisandra chinensis, 5-10 parts of myrobalan, 10-15 parts of fructus psoraleae, 5-8 parts of nandina, 5-10 parts of diaphragma juglandis, 15-25 parts of epimedium herb, 5-7 parts of clove, 3-6 parts of aconite, 3-6 parts of cimicifugae foetidae, 5-10 parts of dried ginger, 3-6 parts of pepper, 8-15 parts of ginseng, 15-25 parts of dogwood, 5-15 parts of astragalus, 15-25 parts of sealwort, 5-15 parts of lucid ganoderma, 5-10 parts of gastrodia elata, 15-25 parts of Chinese yam, 15-25 parts of poria cocos, 5-10 parts of tricholoma matsutake, 15-25 parts of medlar, 15-, 15-25 parts of sharpleaf galangal fruit, 5-10 parts of dried orange peel, 5-10 parts of cordyceps militaris, 5-10 parts of maca powder, 15-25 parts of lalang grass rhizome, 15-25 parts of liquorice and 5-10 parts of rock candy.

The invention also provides a method for preparing the health wine from the traditional Chinese medicine composition of the medicinal wine for resisting fatigue and improving sexual function, which comprises the following steps:

(1) selecting, cleaning, drying, mixing and crushing cistanche, prepared rehmannia root, acanthopanax root, leek seed, nameless fruit, Chinese magnoliavine fruit, myrobalan, malaytea scurfpea fruit, nandina, diaphragma juglandis, epimedium herb, clove, aconite, cimicifuga foetida, dried ginger, pepper, ginseng, dogwood, astragalus mongholicus, sealwort, lucid ganoderma, gastrodia elata, Chinese yam, poria cocos, tricholoma matsutake, wolfberry fruit, mulberry fruit, sharpleaf galangal fruit, dried orange peel, cordyceps militaris, maca powder, lalang grass rhizome and liquorice according to requirements, adding 2-10 times of water for decocting twice, decocting for 2-5 hours for the first time and 1-4 hours for the second time, combining decoction, retaining filter residues, filtering decoction, concentrating the filtrate at 60 ℃ under reduced pressure to obtain clear paste with the;

(2) adding 2-10 times volume of 50-80% ethanol into the filter residue in step (1), reflux extracting for 2 times, each time for 1-4 hr, filtering, mixing filtrates, distilling under reduced pressure to remove ethanol, and concentrating at 60 deg.C to obtain fluid extract with relative density of 1.12-1.18;

(3) heating the clear paste obtained in the step (1) and the step (2) to 50-80 ℃, filtering the clear paste through a 200-fold sieve and a 400-fold sieve when the clear paste is hot, performing spray drying on the filtrate to obtain spray-dried powder, and uniformly mixing the spray-dried powder through a 100-fold sieve and a 200-fold sieve to obtain fine powder for later use;

(4) decocting 5-10 parts of rock sugar for later use;

(5) adding the wine liquid with the calculated dose and the specified alcoholic strength into an aging wine tank by using purified water for later use;

(6) and (4) mixing the fine powder obtained in the step (3), the rock sugar obtained in the step (4) and the aged wine obtained in the step (5), stirring, standing for aging, filtering and bottling.

The traditional Chinese medicine composition disclosed by the invention is scientific and reasonable in formula on the basis of the traditional Chinese medicine of China, has the effects of nourishing yin and tonifying kidney, dredging liver qi and tonifying qi and blood, has a remarkable curative effect on phlegm-heat liver depression type and kidney deficiency and blood stasis type impotence, and has a remarkable improvement effect on symptoms such as soreness and weakness of waist and knees, dizziness and tinnitus, mental fatigue and weakness, spermatorrhea and premature ejaculation, frequent nocturia, hypomnesis and the like caused by kidney deficiency. The traditional Chinese medicine composition has no obvious adverse reaction and side effect after clinical application and follow-up visit, and has stable curative effect.

After the traditional Chinese medicine composition is decocted and extracted by water, the content of active ingredients is higher, and the traditional Chinese medicine composition can be further prepared into forms which are more easily accepted by patients, such as decoction, pills, tablets, capsules, granules, oral liquid and the like, so that a wide space is reserved for developing products in the later period. The percolation extraction of partial Chinese medicinal materials can better retain the color, aroma and taste of the Chinese medicinal materials, so that the finished wine has fuller mouthfeel and is more pleasant to drink. The method for preparing the traditional Chinese medicine preparation has the advantages of easily available raw materials, simple steps and good repeatability, and meets the requirements of industrial production.

The cistanche deserticola in the formula has the effects of tonifying kidney yang, benefiting essence and blood, and relaxing bowel, and is used for treating impotence, infertility, soreness and weakness of waist and knees, and weakness of muscles and bones. Has the effect of controlling the overall rate and is a monarch drug. Radix rehmanniae Preparata has effects of replenishing blood, nourishing yin, replenishing essence, and nourishing marrow; acanthopanax senticosus has the effects of promoting sexual desire and resisting fatigue, and is used for treating spleen-kidney yang deficiency, soreness and weakness of waist and knees, drowsiness and hypodynamia; ginseng, radix Acanthopanacis Senticosi and radix rehmanniae Preparata, has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, tranquilizing mind, and improving intelligence. Leek seeds warm and nourish liver and kidney, strengthen yang and consolidate semen, strengthen tendons and bones, nameless juba seeds warm kidney and spleen, schisandra chinensis astringe and consolidate, replenish qi and promote fluid production, tonify kidney, myrobalan tonify lung and cure frequent micturition and spermatorrhea, malaytea scurfpea fruit tonify kidney and strengthen yang, consolidate semen and reduce urination, warm spleen and check diarrhea, nandina bamboo liver-clearing and eyesight-improving, astringe lung and relieve asthma, diaphoresis and astringe semen and reduce urination, epimedium tonify kidney and strengthen yang, expel wind and remove dampness, clove warms middle-jiao and lowers adverse qi, promote qi circulation and relieve pain, warm kidney and strengthen yang, accessory piece warms up spleen and kidney, dispels cold and relieve pain, revive yang and relieve adverse rise to the cold, cimicifuga foetida raises yang and lowers subsidence of yang, tonify spleen and dispel cold, return yang and dredge collaterals, warm lung and dissolve fluid retention, pepper warms middle-qi and move qi, cornus officinalis. The health-care tea mainly treats consumptive disease and physical weakness, mental fatigue, gastrodia elata, wind calming and convulsion relieving, liver yang calming, wind dispelling and collateral dredging, wolfberry, liver and kidney nourishing, essence boosting and eyesight improving, mulberry, yin nourishing and blood enriching, liver and kidney tonifying, body fluid production promoting and thirst quenching, fructus alpiniae oxyphyllae, spleen warming and diarrhea checking, saliva control, kidney warming, urination reducing and essence controlling, cordyceps militaris, impotence and spermatorrhea, waist and knee soreness and pain, maca powder, fatigue resistance, physical strength enhancement, sperm quality increasing and sperm activity increasing. On the basis of the leading of ministerial drugs, the Chinese medicinal composition and the preparation method jointly assist the invigorating kidney and strengthening yang of monarch drugs, add the efficacy of the ministerial drugs in tonifying qi and resisting fatigue, and combine to form an adjuvant drug, thereby protecting the efficacy of the monarch drugs. The Chinese yam has the effects of tonifying spleen and promoting fluid production, the poria cocos has the effects of tonifying spleen and nourishing stomach, the tricholoma matsutake has the effects of protecting liver and promoting gastrointestinal digestion, enhancing fragrance and seasoning, the dried orange peel has the effect of regulating qi and harmonizing the middle warmer, the liquorice has the effect of harmonizing the other drugs, and the monarch and minister drugs have the effects of tonifying yang without dryness and nourishing yin without greasiness, and are also used as guiding drugs. The medicines are used as monarch, minister, assistant and guide medicines and are applied to the medicines respectively to ensure that the medicines achieve the effects of tonifying yang, resisting fatigue and improving sexual function.

In order to prove the effect of the anti-fatigue and sexual function improving medicinal liquor of the invention, 100 testers are systematically observed:

the test population: the male, age between 35-70 years, has no serious primary diseases such as cardiovascular, liver, kidney, diabetes, etc.

Protocol to be tested: the drinking of the wine product of the invention is carried out once a day, morning and evening, and the drinking amount is 35-50ml each time.

Time: for 90 days.

The effective standard is as follows: eliminating fatigue, invigorating energy, stimulating appetite, improving thinking activity, improving sleep, relaxing mind, improving body constitution, improving resistance to external stimulation (cold and heat), and delaying sexual life fatigue.

The effective rate reaches 98% after 98 persons meeting the effective standard in a statistical observation period. No adverse reaction is found in the drinking process, and the drinking is safe.

Detailed Description

Example 1

The embodiment provides a medicinal liquor and a traditional Chinese medicine composition for resisting fatigue and improving sexual function; weighing the following raw materials (kg):

20 parts of cistanche, 20 parts of prepared rehmannia root, 12 parts of acanthopanax, 6 parts of leek seeds, 7 parts of nameless seeds, 17 parts of schisandra chinensis, 8 parts of myrobalan, 12 parts of fructus psoraleae, 7 parts of nandina, 7 parts of diaphragma juglandis, 20 parts of epimedium, 6 parts of clove, 4 parts of radix aconiti lateralis preparata, 4 parts of cimicifugae foetidae, 7 parts of dried ginger, 4 parts of pepper, 10 parts of ginseng, 20 parts of dogwood, 10 parts of astragalus mongholicus, 20 parts of rhizoma polygonati, 10 parts of ganoderma lucidum, 7 parts of gastrodia elata, 20 parts of Chinese yam, 20 parts of poria cocos, 7 parts of tricho.

The preparation method comprises the following steps:

(1) weighing cistanche, prepared rehmannia root, acanthopanax, leek seed, nameless fruit, schisandra chinensis, myrobalan, fructus psoraleae, nandina, diaphragma juglandis, epimedium, clove, radix aconiti lateralis preparata, rhizoma cimicifugae, rhizoma zingiberis, pepper, ginseng, dogwood, astragalus mongholicus, rhizoma polygonati, lucid ganoderma, rhizoma gastrodiae, Chinese yam, poria cocos, tricholoma matsutake, wolfberry, mulberry, fructus alpiniae oxyphyllae, dried tangerine or orange peel, cordyceps militaris, maca powder, lalang grass rhizome and liquorice, selecting, cleaning, drying, mixing and crushing according to requirements, adding 2-10 times of water for decocting twice, adding 8 times of purified water for decocting for 5 hours for the first time, adding 6 times of purified water for decocting for 4 hours for the second time, combining decoctions, retaining filter residues, filtering the decoctions, concentrating the filtrate at 60 ℃ under reduced pressure to obtain;

(2) adding 8 times volume of 60% ethanol into the filter residue in the step (1), reflux-extracting for 2 times, each time for 2 hours, filtering, combining the filtrates, then distilling under reduced pressure to remove ethanol, and concentrating at 60 deg.C to obtain fluid extract with relative density of 1.12-1.18;

(3) heating the clear paste obtained in the step (1) and the step (2) to 80 ℃, filtering the clear paste through a 200-mesh and 400-mesh sieve while the clear paste is hot, performing spray drying on the filtrate to obtain spray-dried powder, and uniformly mixing the spray-dried powder and the filtrate through a 150-mesh sieve to obtain fine powder for later use;

(4) decocting crystal sugar;

(6) mixing (3), (4) and (5), stirring, standing and aging for 15 days, filtering and bottling.

Example 2

16 parts of cistanche deserticola, 15 parts of prepared rehmannia root, 10 parts of acanthopanax, 5 parts of leek seed, 5 parts of nameless cardamom, 15 parts of schisandra chinensis, 6 parts of myrobalan, 10 parts of fructus psoraleae, 5 parts of nandina, 6 parts of diaphragma juglandis, 15 parts of epimedium, 5 parts of clove, 3 parts of radix aconiti lateralis preparata, 3 parts of cimicifuga foetida, 5 parts of dried ginger, 3 parts of pepper, 8 parts of ginseng, 15 parts of dogwood, 7 parts of astragalus mongholicus, 15 parts of rhizoma polygonati, 6 parts of ganoderma lucidum, 6 parts of rhizoma gastrodiae, 15 parts of Chinese yam, 15 parts of poria cocos.

The preparation method comprises the following steps:

(1) weighing cistanche, prepared rehmannia root, acanthopanax, leek seed, nameless fruit, schisandra chinensis, myrobalan, fructus psoraleae, nandina, diaphragma juglandis, epimedium, clove, radix aconiti lateralis preparata, rhizoma cimicifugae, rhizoma zingiberis, pepper, ginseng, dogwood, astragalus mongholicus, rhizoma polygonati, lucid ganoderma, rhizoma gastrodiae, Chinese yam, poria cocos, tricholoma matsutake, wolfberry, mulberry, fructus alpiniae oxyphyllae, dried tangerine or orange peel, cordyceps militaris, maca powder, lalang grass rhizome and liquorice, selecting, cleaning, drying, mixing and crushing according to requirements, adding 2-10 times of water for decocting twice, adding 9 times of purified water for decocting for 5 hours for the first time, adding 5 times of purified water for decocting for 4 hours for the second time, combining decoctions, retaining filter residues, filtering the decoctions, concentrating the filtrate at 60 ℃ under reduced pressure to obtain;

(2) adding 70% ethanol 8 times the volume of the filter residue in the step (1), reflux-extracting for 2 times, each time for 2 hours, filtering, combining the filtrates, then distilling under reduced pressure to remove ethanol, and concentrating at 60 deg.C to obtain fluid extract with relative density of 1.12-1.18;

(3) heating the clear paste obtained in the step (1) and the step (2) to 80 ℃, filtering the hot clear paste through a 200-mesh sieve, performing spray drying on the filtrate to obtain spray-dried powder, adding the fine powder obtained in the step (2), sieving through a 150-mesh sieve, and uniformly mixing to obtain fine powder for later use;

(4) decocting crystal sugar;

(6) mixing the components (3), (4) and (5), stirring, standing and aging for 20 days, filtering and bottling.

Example 3

25 parts of cistanche deserticola, 25 parts of prepared rehmannia root, 15 parts of acanthopanax, 8 parts of leek seeds, 5 parts of nameless seeds, 18 parts of schisandra chinensis, 8 parts of myrobalan, 15 parts of fructus psoraleae, 8 parts of nandina, 10 parts of diaphragma juglandis, 24 parts of epimedium, 7 parts of clove, 5 parts of radix aconiti lateralis preparata, 5 parts of rhizoma cimicifugae, 10 parts of dried ginger, 5 parts of pepper, 15 parts of ginseng, 23 parts of dogwood, 15 parts of astragalus mongholicus, 24 parts of rhizoma polygonati, 13 parts of ganoderma lucidum, 10 parts of rhizoma gastrodiae, 23 parts of Chinese yam, 25 parts of poria cocos, 10 parts.

The preparation method comprises the following steps:

(1) weighing cistanche, prepared rehmannia root, acanthopanax, leek seed, nameless fruit, schisandra chinensis, myrobalan, fructus psoraleae, nandina, diaphragma juglandis, epimedium, clove, radix aconiti lateralis preparata, rhizoma cimicifugae, rhizoma zingiberis, pepper, ginseng, dogwood, astragalus mongholicus, rhizoma polygonati, lucid ganoderma, rhizoma gastrodiae, Chinese yam, poria cocos, tricholoma matsutake, wolfberry, mulberry, fructus alpiniae oxyphyllae, dried tangerine or orange peel, cordyceps militaris, maca powder, lalang grass rhizome and liquorice, selecting, cleaning, drying, mixing and crushing according to requirements, adding 2-10 times of purified water for decocting twice, adding 10 times of purified water for decocting for 5 hours for the first time, adding 5 times of purified water for decocting for 3 hours for the second time, combining decoction, reserving filter residues, filtering the decoction, concentrating the filtrate at 60 ℃ under reduced;

(2) adding 80% ethanol with the volume 7 times of the filter residue in the step (1), performing reflux extraction for 2 times, 3 hours each time, filtering, combining filtrates, then distilling under reduced pressure to remove ethanol, and concentrating at 60 ℃ to obtain fluid extract with relative density of 1.12-1.18 for later use;

(3) heating the clear paste obtained in the step (1) and the step (2) to 50 ℃, filtering the hot clear paste through a 400-mesh sieve, spray-drying the filtrate to obtain spray-dried powder, and uniformly mixing the spray-dried powder and the filtrate through a 200-mesh sieve to obtain fine powder for later use;

(4) decocting crystal sugar;

(6) mixing the above materials (3), (4) and (5), stirring, standing and aging for 30 days, collecting supernatant, filtering, and bottling.

The above description is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any modification and replacement based on the technical solution and inventive concept provided by the present invention should be covered within the scope of the present invention.

Claims

1. A traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function is characterized by being prepared from the following traditional Chinese medicines in parts by weight:

15-25 parts of cistanche, 15-25 parts of prepared rehmannia root, 10-15 parts of acanthopanax, 5-8 parts of leek seed, 5-8 parts of nameless, 15-20 parts of schisandra chinensis, 5-10 parts of myrobalan, 10-15 parts of fructus psoraleae, 5-8 parts of nandina, 5-10 parts of diaphragma juglandis, 15-25 parts of epimedium herb, 5-7 parts of clove, 3-6 parts of aconite, 3-6 parts of cimicifugae foetidae, 5-10 parts of dried ginger, 3-6 parts of pepper, 8-15 parts of ginseng, 15-25 parts of dogwood, 5-15 parts of astragalus, 15-25 parts of sealwort, 5-15 parts of lucid ganoderma, 5-10 parts of gastrodia elata, 15-25 parts of Chinese yam, 15-25 parts of poria cocos, 5-10 parts of tricholoma matsutake, 15-25 parts of medlar, 15-25 parts of mulberry, 15-25, 5-10 parts of dried orange peel, 5-10 parts of cordyceps militaris, 5-10 parts of maca powder, 15-25 parts of lalang grass rhizome, 15-25 parts of liquorice and 5-10 parts of rock candy.

2. The method for preparing the health wine from the traditional Chinese medicine composition of the medicinal wine for resisting fatigue and improving sexual function according to claim 1 is characterized by comprising the following steps:

(4) decocting 5-10 parts of rock sugar for later use;