CN114916596A - Traditional Chinese medicine tea drink with anti-fatigue effect and appetite increasing effect - Google Patents
Traditional Chinese medicine tea drink with anti-fatigue effect and appetite increasing effect Download PDFInfo
- Publication number
- CN114916596A CN114916596A CN202210254321.9A CN202210254321A CN114916596A CN 114916596 A CN114916596 A CN 114916596A CN 202210254321 A CN202210254321 A CN 202210254321A CN 114916596 A CN114916596 A CN 114916596A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- traditional chinese
- fatigue
- cistanche
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 84
- 230000000694 effects Effects 0.000 title claims abstract description 56
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 30
- 230000036528 appetite Effects 0.000 title claims abstract description 21
- 235000019789 appetite Nutrition 0.000 title claims abstract description 21
- 241001122767 Theaceae Species 0.000 title claims description 55
- 230000001965 increasing effect Effects 0.000 title description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 78
- 241000005787 Cistanche Species 0.000 claims abstract description 72
- 239000000843 powder Substances 0.000 claims abstract description 42
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 18
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 16
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 16
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 241000572565 Alpinia oxyphylla Species 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000002671 adjuvant Substances 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 57
- 238000000605 extraction Methods 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 18
- 238000010992 reflux Methods 0.000 claims description 13
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 12
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 12
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 12
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 12
- 229920006316 polyvinylpyrrolidine Polymers 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 241000756042 Polygonatum Species 0.000 claims description 7
- 230000036541 health Effects 0.000 claims description 7
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 6
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 6
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000007779 soft material Substances 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 238000000643 oven drying Methods 0.000 claims description 5
- 244000062241 Kaempferia galanga Species 0.000 claims 1
- 235000013421 Kaempferia galanga Nutrition 0.000 claims 1
- 244000182216 Mimusops elengi Species 0.000 claims 1
- 238000007873 sieving Methods 0.000 claims 1
- 230000009467 reduction Effects 0.000 abstract description 13
- 235000012631 food intake Nutrition 0.000 abstract description 11
- 230000037406 food intake Effects 0.000 abstract description 10
- 102000016267 Leptin Human genes 0.000 abstract description 9
- 108010092277 Leptin Proteins 0.000 abstract description 9
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 abstract description 9
- 229940039781 leptin Drugs 0.000 abstract description 9
- 230000019522 cellular metabolic process Effects 0.000 abstract description 8
- 230000028327 secretion Effects 0.000 abstract description 8
- 210000003205 muscle Anatomy 0.000 abstract description 7
- 239000002245 particle Substances 0.000 abstract description 2
- 244000269722 Thea sinensis Species 0.000 abstract 6
- 206010016256 fatigue Diseases 0.000 description 36
- 235000013616 tea Nutrition 0.000 description 36
- 229940079593 drug Drugs 0.000 description 23
- 238000011160 research Methods 0.000 description 19
- 241000336291 Cistanche deserticola Species 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 210000003734 kidney Anatomy 0.000 description 14
- 241000699670 Mus sp. Species 0.000 description 13
- 239000008280 blood Substances 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 9
- 230000004060 metabolic process Effects 0.000 description 9
- 239000002207 metabolite Substances 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 9
- 230000007812 deficiency Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- 229920002527 Glycogen Polymers 0.000 description 7
- 229940096919 glycogen Drugs 0.000 description 7
- 230000036039 immunity Effects 0.000 description 7
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 6
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 6
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 6
- 230000002708 enhancing effect Effects 0.000 description 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 238000000465 moulding Methods 0.000 description 6
- 230000002040 relaxant effect Effects 0.000 description 6
- 240000002624 Mespilus germanica Species 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000012004 Ghrelin Human genes 0.000 description 4
- 101800001586 Ghrelin Proteins 0.000 description 4
- 240000005373 Panax quinquefolius Species 0.000 description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 230000033764 rhythmic process Effects 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 108010024636 Glutathione Proteins 0.000 description 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 229940000635 beta-alanine Drugs 0.000 description 3
- 210000000941 bile Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000011194 food seasoning agent Nutrition 0.000 description 3
- 235000008434 ginseng Nutrition 0.000 description 3
- 229960003180 glutathione Drugs 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 239000002398 materia medica Substances 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 230000037353 metabolic pathway Effects 0.000 description 3
- 230000004144 purine metabolism Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 239000000052 vinegar Substances 0.000 description 3
- 235000021419 vinegar Nutrition 0.000 description 3
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 description 2
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 description 2
- 244000020518 Carthamus tinctorius Species 0.000 description 2
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 2
- 241000336315 Cistanche salsa Species 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 241001165494 Rhodiola Species 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000037080 exercise endurance Effects 0.000 description 2
- 235000020335 flavoured tea Nutrition 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 235000015092 herbal tea Nutrition 0.000 description 2
- 208000000509 infertility Diseases 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 231100000535 infertility Toxicity 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 108091006112 ATPases Proteins 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 241000336316 Cistanche tubulosa Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 240000007371 Cuscuta campestris Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 235000002722 Dioscorea batatas Nutrition 0.000 description 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 1
- 240000001811 Dioscorea oppositifolia Species 0.000 description 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000893536 Epimedium Species 0.000 description 1
- 241000208688 Eucommia Species 0.000 description 1
- 241000222336 Ganoderma Species 0.000 description 1
- 241000229143 Hippophae Species 0.000 description 1
- 235000003935 Hippophae Nutrition 0.000 description 1
- 240000000950 Hippophae rhamnoides Species 0.000 description 1
- 235000003145 Hippophae rhamnoides Nutrition 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 1
- 241000308150 Orobanchaceae Species 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 241000037831 Polygonatum sibiricum Species 0.000 description 1
- 238000012356 Product development Methods 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 244000042430 Rhodiola rosea Species 0.000 description 1
- 235000003713 Rhodiola rosea Nutrition 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 240000006079 Schisandra chinensis Species 0.000 description 1
- 208000008630 Sialorrhea Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 235000006545 Ziziphus mauritiana Nutrition 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 235000021551 crystal sugar Nutrition 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- FSBUXLDOLNLABB-ISAKITKMSA-N echinacoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O[C@@H](OCCC=2C=C(O)C(O)=CC=2)[C@@H]1O FSBUXLDOLNLABB-ISAKITKMSA-N 0.000 description 1
- NJYVDFDTLLZVMG-UHFFFAOYSA-N echinacoside Natural products CC1OC(OC2C(O)C(OCCc3ccc(O)c(O)c3)OC(COC4OC(CO)C(O)C(O)C4O)C2OC(=O)C=Cc5cc(O)cc(O)c5)C(O)C(O)C1O NJYVDFDTLLZVMG-UHFFFAOYSA-N 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000018905 epimedium Nutrition 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- -1 glycosides compounds Chemical class 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000015091 medicinal tea Nutrition 0.000 description 1
- 230000006993 memory improvement Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000000955 neuroendocrine Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000011506 response to oxidative stress Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- KDSWDGKIENPKLB-QJDQKFITSA-N verbascoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC(=O)CCC=2C=C(O)C(O)=CC=2)[C@@H](CO)O[C@@H](OCCC=2C=C(O)C(O)=CC=2)[C@@H]1O KDSWDGKIENPKLB-QJDQKFITSA-N 0.000 description 1
- QFRYQWYZSQDFOS-UHFFFAOYSA-N verbascoside Natural products CC1OC(COC2C(O)C(COC3OC(C(O)C(O)C3O)C(=O)O)OC(Oc4cc(O)cc5OC(=CC(=O)c45)c6ccc(O)c(O)c6)C2O)C(O)C(O)C1O QFRYQWYZSQDFOS-UHFFFAOYSA-N 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/06—Treating tea before extraction; Preparations produced thereby
- A23F3/14—Tea preparations, e.g. using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine tea drink with anti-fatigue and appetite-improving effects, which is a traditional Chinese medicine tea drink particle prepared by taking cistanche, rhizoma polygonati, fructus alpiniae oxyphyllae and wolfberry fruit as raw materials and taking tea powder as an auxiliary material, wherein the dosage of the raw materials is as follows: 550-650 parts of cistanche powder, 850-950 parts of rhizoma polygonati, 550-650 parts of fructus alpiniae oxyphyllae and 670-770 parts of fructus lycii. The invention also discloses a preparation method thereof: extracting Cistanchis herba, rhizoma Polygonati, fructus Alpinae Oxyphyllae and fructus Lycii with ethanol solution to obtain extractive solution, adding tea powder, adding adjuvants, and granulating. The traditional Chinese medicine tea drink is applied to being used as or being prepared into health-care products with the effects of resisting fatigue and improving appetite. The traditional Chinese medicine tea drink can improve the weight and food intake reduction of fatigue people, slow down the fatigue degree of muscles, reduce leptin secretion to improve appetite reduction, increase VB6 to improve cell metabolism operation, thereby achieving the effects of improving the whole body quality, preventing fatigue and resisting fatigue.
Description
Technical Field
The invention relates to a traditional Chinese medicine tea drink with an anti-fatigue effect and an appetite improving effect, and belongs to the technical field of health-care products.
Background
Cistanche deserticola is the succulent stem of cistanche deserticola and cistanche tubulosa belonging to cistanche genus of Orobanchaceae family, and is also called cistanche deserticola and Cistanchis herba in the book of Chinese materia Medica, and is also called cistanche deserticola and black commander in the book of Wu Pu Ben Cao. The cistanche deserticola is sweet, salty and warm in taste, enters kidney and large intestine channels, has the effects of tonifying kidney yang, benefiting essence and blood, relaxing bowel and the like, and is found to have the effects of relaxing bowel, resisting osteoporosis, resisting oxidation, resisting aging, resisting fatigue, protecting liver, enhancing immunity, enhancing memory and the like by modern pharmacological research.
Cistanche deserticola belongs to the ' top grade ' for tonifying deficiency in the first Chinese materia medica monograph of China ' Shen nong Ben Cao Jing; in the Tang Dynasty, it is classified as one of the nine-god-fairy-grass of China. Li Shizhen's compendium of materia Medica says: "this substance is tonifying but not drastic, so it has the 'leisurely' number. In the theory of traditional Chinese medicine, cistanche is used for kidney-yang deficiency, essence and blood deficiency, impotence and infertility, soreness and weakness of waist and knees, muscle and bone weakness, intestinal dryness and constipation and the like, is a famous and precious traditional Chinese medicine and has the reputation of desert ginseng. The cistanche deserticola is also used in a plurality of health care medicines and foods at present, has the main effects of relaxing bowel, resisting aging, resisting fatigue, enhancing immunity, enhancing memory and the like, and is a good product for both medicine and food. According to statistics, the incidence of cistanche in the past generation reinforcing traditional Chinese medicine prescription is 1 st, while the incidence of cistanche in the anti-aging and anti-aging traditional Chinese medicine prescription is only second to ginseng 2 nd. At present, the research on cistanche is mostly focused on the application of the efficacies of tonifying kidney and strengthening yang and relaxing bowel, and relatively few researches on the application aspect of the antifatigue efficacy are carried out.
The main active ingredient of Cistanchis herba is phenylethanoid glycosides compounds, including echinacoside, verbascoside, etc. Yan Lei et al, compared with cistanche experiments with low dose of 100mg/kg and high dose of 400mg/kg, found that the higher the purity of cistanche active ingredients, the better the anti-fatigue effect of cistanche (P < 0.01). Zeng Ke Wu et al summarize 18 target proteins of herba cistanches, and fundamentally release the connotation of herba cistanches phenylethanoid glycosides in resisting oxidation, fatigue, tumor, ion channel and immunoregulation.
The anti-fatigue mechanism of cistanche deserticola is embodied in the following three aspects: firstly, the content of various motor metabolites in a mouse body is obviously reduced; such as blood Lactic Acid (LA), Blood Urea Nitrogen (BUN), etc. Secondly, improving the reserve of glycogen of the organism and changing reactants of energy metabolism, such as increasing the reserve of liver glycogen and muscle glycogen by supplementing nutrient substances, supplementing glycogen by the sex hormone-like action of active ingredients of the glycogen, indirectly generating anti-fatigue effect and the like; and thirdly, enhancing the activity of related antioxidant enzymes, and generating the associated effect of fatigue resistance on the basis of oxidative stress reaction, such as antioxidant reaction and the like. It is worth mentioning that, from the blank condition of various animal experiments, the effect of cistanche on fatigue models is mainly to restore the rhythm of the organism to normal from the function angle, rather than mechanically increase or decrease from the matter angle, which embodies the concept of 'complement and deficiency' in the traditional Chinese medicine, and shows that the effect of cistanche on human body is 'consequent', in short, no 'complement excess' and no 'reduce excess', so that the organism is in dynamic balance and conforms to the complex biological rhythm.
The registered cistanche health-care product has the following effects: the number of cistanche health-care products registered in the national food and drug administration is 48, wherein 46 of the cistanche health-care products are domestic health-care products, and 2 of the cistanche health-care products are imported health-care products. The distribution of the efficacies of the health care products is as follows: the traditional Chinese medicine composition has 27 types of efficacies of resisting fatigue and relieving physical fatigue, 22 types of efficacies of enhancing immunity and regulating immunity, 8 types of efficacies of delaying senility, 2 types of efficacies of improving gastrointestinal tract function and relaxing bowel, 1 type of efficacy of antioxidation, 1 type of efficacy of assisting in improving memory, 1 type of efficacy of increasing bone density and 1 type of efficacy of regulating blood fat. Combining the traditional Chinese medicine efficacy of cistanche, the application of cistanche can be divided into three categories of tonifying kidney yang, benefiting essence and blood and relaxing bowel, and the anti-fatigue efficacy of the efficacies is most applied, and the possible reasons are as follows: (1) modern pharmacology has more intensive research on the fatigue resistance of the cistanche; (2) modern people are mostly in a sub-health state, and the sub-health state is most easily characterized by fatigue, and the cistanche health care product capable of resisting fatigue can stimulate the purchasing desire of consumers more easily.
The registered cistanche health-care product has the main compatibility conditions as follows: when the cistanche health-care product is applied to tonifying kidney yang, the main compatible medicines are as follows: medlar, ginseng, epimedium herb, dodder, lucid ganoderma, rehmannia root, Chinese date, Chinese magnoliavine fruit, Chinese angelica, astragalus root, safflower, Chinese yam, clove, rhodiola rosea, pilose antler, cinnamon, American ginseng, cordyceps sinensis, eucommia bark and the like.
The registered cistanche health-care product has the following efficacy characteristics of the compatible medicines: in the formula of the health-care product, the cistanche is taken as a main drug, and the matched drug has the following characteristics: most warm, a few are: the mulberry and the rhodiola root are cold, and the honey and the crystal sugar are flat; sweet flavor is mostly, but a few are: flos Caryophylli and Carthami flos are pungent, fructus Hippophae and fructus Schisandrae chinensis are sour; the kidney meridian entered most, and then the spleen meridian, liver meridian and lung meridian entered least; the main actions are tonifying the zang-fu organs, essence, body fluid, qi, blood, yin and yang, and the few are: safflower, rhodiola root, seabuckthorn fruit, etc. have the functions of dissipating blood stasis. The compatibility of medicines has sweet and warm property, can tonify yang and strengthen yang, enter kidney channel, can directly tonify congenital qi-blood yin-yang, enter spleen channel, can tonify acquired qi and yang to tonify congenital qi-blood yang, and has the efficacy of tonifying essence, fluid, qi-blood yin-yang, so the compatibility of medicines can strengthen the efficacy of tonifying kidney yang of cistanche.
At present, cistanche health-care products are in the initial stage of development, and the following problems also exist: the patent application related to cistanche health-care products accounts for a large proportion of the medicines for treating infertility, cardiovascular diseases, gynecological diseases and andrological diseases, and modern researches prove the action mechanism of cistanche for treating diseases of reproductive system and cardiovascular system, but registered health-care products do not show the effects. The reasons for this may be: (1) the current scientific technology has not reached the level of industrialization of these patent applications; (2) people have insufficient awareness of health care products with the functions, the market of the health care products is not opened, and enterprises are reluctant to produce the health care products.
The current society develops at a high speed, the life rhythm of people is continuously accelerated, a large number of people are in a sub-health state or an unhealthy state, and the prominent expression is the reduction of fatigue state and thinking memory capability. Fatigue is a physiological or psychological phenomenon produced after a body is in high intensity or is in activity for a long time, and is manifested as physical drowsiness, mental lassitude, attention loss, and work efficiency reduction, and pathological damage can be developed when the body is frequently in a fatigue state. At present, the curative effect of the common clinical chemical medicines is not obvious, the mechanism of fatigue resistance and memory enhancement of the cistanche is clarified, the development and the application of the traditional Chinese medicine products are promoted, and the potential economic benefit and the social benefit are huge.
The existing patent applications of the anti-fatigue product types and the traditional Chinese medicine formula in the market are not rare, but part of the patent applications focus on the anti-fatigue research of the traditional Chinese medicine formula granules, but no complete animal research data exists; the sugar-containing vinegar is partially prepared into the forms of vinegar and wine, and the two forms cannot be accepted by the vast population, for example, the audience of the sugar-containing vinegar needs to avoid some diabetic population. Some patent applications also have basic research data of animal experiments, but all the patent applications focus on the research on inhibiting or reducing the generation of serum urea nitrogen of fatigue mice after exercise and improving liver glycogen required for prolonging exercise endurance so as to achieve the anti-fatigue effect.
Disclosure of Invention
Aiming at the prior art, the invention provides a traditional Chinese medicine tea drink which takes cistanche as a main raw material and has the effects of resisting fatigue and improving appetite. The product formula of the invention is based on the theory of traditional Chinese medicine, is based on the research of clinical modern drug tests and passes through the research of animal tests, and the product effect has exact scientific research foundation. The product is taken by being mixed with tea granules, so that the tea granule is very suitable for students and working people with modern fast pace of life, is very convenient to take, can be taken by being mixed with warm water, and is suitable for retired elderly people (the inconvenience in use caused by the complex using method of the product is avoided). The invention researches and proves that the compound tea taking the cistanche as the main drug has the function of resisting fatigue. The invention has passed through the animal experiment stage, based on the research and reproduction of the traditional Chinese medicine syndrome animal model, observes the general condition of the model animal, detects the change of laboratory indexes such as behavioral indexes, physiological and biochemical neuroendocrine and the like of the model animal, develops the research on the biological foundation and mechanism of the anti-fatigue of the cistanche, compares the action differences of the cistanche single product and the formula tea of the product, and provides scientific basis for the product development.
The invention is realized by the following technical scheme:
a traditional Chinese medicine tea drink with anti-fatigue and appetite-improving effects is a traditional Chinese medicine tea drink particle prepared by a conventional process by taking cistanche, rhizoma polygonati, fructus alpiniae oxyphyllae and wolfberry fruit as raw materials and tea powder as an auxiliary material, wherein the dosage proportion of the cistanche, the rhizoma polygonati, the fructus alpiniae oxyphyllae and the wolfberry fruit is as follows (in parts by weight): 550-650 parts of cistanche powder, 850-950 parts of rhizoma polygonati, 550-650 parts of fructus alpiniae oxyphyllae and 670-770 parts of fructus lycii; preferably, the dosage proportion relationship is as follows: 600 parts of cistanche powder, 900 parts of rhizoma polygonati, 600 parts of fructus alpiniae oxyphyllae and 720 parts of fructus lycii.
Further, the using amount of the tea powder is 700-750 parts, preferably 720 parts.
Further, the tea powder is selected from 60 mesh ripe tea fine powder.
The preparation method of the traditional Chinese medicine tea drink with the anti-fatigue effect and the appetite improving effect comprises the following steps: extracting Cistanchis herba, rhizoma Polygonati, fructus Alpinae Oxyphyllae and fructus Lycii with ethanol solution to obtain extractive solution, adding tea powder, adding adjuvants, and granulating.
Further, the volume concentration of the ethanol solution is 45-55%.
Further, the dosage of the ethanol solution is 10-15 times.
Furthermore, the extraction times are two, and the extraction time is 1.5-2.5 hours each time.
Further, the auxiliary materials are selected from polyvinylpyrrolidone K90 and sodium carboxymethyl cellulose.
Specifically, the preparation method comprises the following steps:
(1) adding cistanche, polygonatum, fructus alpiniae oxyphyllae and wolfberry fruit into an ethanol solution, soaking for 20-40 minutes, then performing reflux extraction for 1.5-2.5 hours, filtering, adding the ethanol solution into the dregs of a decoction, performing reflux extraction for 1.5-2.5 hours, combining the two extracting solutions, and concentrating to obtain a concentrated solution;
wherein, the volume concentration of the ethanol solution is 45-55%, preferably 50%, and the dosage of the ethanol solution is 10-15 times (the times of the total weight of the desertliving cistanche, the rhizoma polygonati, the fructus alpiniae oxyphyllae and the fructus lycii), preferably 12 times.
(2) Adding the flavored tea powder into the concentrated solution, and mixing well.
(3) Adding a proper amount of polyvinylpyrrolidone K90, and mixing uniformly.
(4) Adding appropriate amount of sodium carboxymethylcellulose water solution, and mixing.
(5) Spraying ethanol to make soft material, extruding, granulating, oven drying, grading with 10 mesh sieve, and removing fine powder with 60 mesh sieve.
The traditional Chinese medicine tea drink is applied to being used as or preparing health-care products with the effects of resisting fatigue and/or improving appetite.
The traditional Chinese medicine tea is applied to preparation of medicines with anti-fatigue and/or appetite improving effects.
The traditional Chinese medicine tea drink can improve the weight and the food intake reduction of fatigue people, slow down the fatigue degree of muscles, reduce leptin secretion to improve the appetite, increase VB6 to improve cell metabolism operation, thereby achieving the effects of improving the whole body quality and preventing fatigue. This is fundamentally different from the prior art (the anti-fatigue efficacy in the prior art is mainly studied to suppress or reduce the production of serum urea nitrogen after fatigue and to increase hepatic glycogen required for prolonging exercise endurance, thereby achieving the anti-fatigue effect).
The product of the invention adopts tea granules as the edible form, and the taking mode of taking the product by being mixed with warm water is very in line with modern people who fast and rhythm life, and the product can be taken along with soaking, so that the people are wide in range.
The traditional Chinese medicine tea drink takes the cistanche salsa, the polygonatum sibiricum, the fructus alpiniae oxyphyllae and the wolfberry fruit as raw materials, wherein the cistanche salsa is taken as a monarch drug, and animal experimental research results show that the anti-fatigue mechanism of the traditional Chinese medicine tea drink is possibly related to purine metabolism, arginine and proline metabolism, beta-alanine metabolism, glutathione metabolism, ABC transport protein, bile secretion and other pathways. The single medicine of cistanche deserticola can increase SDH (succinate dehydrogenase), VB2 and VB6 to improve the cell metabolism operation. Rhizoma polygonati is a traditional Chinese medicine in China, is a plant used as both medicine and food, and has the effect of prolonging life. The sealwort has the main effects of nourishing kidney, moistening lung, tonifying spleen and benefiting qi. Can be used for treating weakness of spleen and stomach, tiredness, debilitation, dry mouth, anorexia, internal heat, diabetes, lung deficiency, cough, kidney essence deficiency, dizziness, soreness of waist and knees, and premature gray hair. Fructus Alpinae Oxyphyllae has effects of warming and invigorating, consolidating and controlling, warming spleen, relieving diarrhea, consolidating semen, and reducing urination, and can be used for treating deficiency cold of spleen and kidney, abdominal pain and diarrhea, or deficiency cold of kidney qi, frequent micturition, enuresis, nocturnal emission, whitish and turbid urine, or diarrhea and sialorrhea due to deficiency cold of spleen and stomach. As the name suggests, it has the effect of improving intelligence. The research proves that the Chinese medicinal composition can improve the memory and enhance the immunity. The wolfberry fruit is sweet in nature and taste, and the traditional Chinese medicine theory considers that the wolfberry fruit can nourish liver and kidney, replenish vital essence to improve eyesight and nourish blood. For modern people, the practical effects of medlar are to enhance immunity, resist fatigue and reduce blood pressure. The four medicines are combined, have mild properties and taste, and can tonify spleen and kidney, resist fatigue, enhance immunity, resist aging and enhance memory.
Drawings
FIG. 1: the influence of cistanche deserticola and the compound thereof on the weight, food intake and on-stick time of mice is disclosed, wherein A: body weight; b: food intake; c: at the rod time. Note: p < 0.05, p <0.01 compared to normal; in comparison to the set of models, ▲ p＜0.05， ▲▲ p＜0.01；n＝10，9，8。
FIG. 2A: the effect of cistanche and the compound thereof on the mouse serum appetite factor Leptin. Note: p < 0.05, p <0.01 as compared to normal group; in comparison to the set of models, ▲ p＜0.05， ▲▲ p＜0.01；n＝6。
FIG. 2B: the effect of cistanche deserticola and the compound thereof on the serum appetite factor Ghrelin of mice. Note: p < 0.05, p <0.01 compared to normal; in comparison to the set of models, ▲ p＜0.05， ▲▲ p＜0.01；n＝6。
FIG. 3: the effect of cistanche and the compound thereof on the serum metabolic enzyme of a mouse, wherein A: na (Na) + -K + -ATPase; b: PK; c: and (7) SDH. Note: p <0.01 compared to normal group; in comparison to the set of models, ▲▲ p＜0.01；n＝6。
FIG. 4: the effect of cistanche deserticola and the compound thereof on the content of B vitamins in urine of mice is disclosed, wherein A: VB 1; b: VB 2; c: VB 6. Note: p < 0.05, p <0.01 as compared to normal group; in comparison to the set of models, ▲ p＜0.05， ▲▲ p＜0.01；n＝6。
FIG. 5: the urine metabolites PLS-DA of each group of mice were analyzed (n ═ 6).
FIG. 6: analyzing differential metabolites and metabolic pathways KEGG of single medicine of cistanche deserticola, wherein A: a metabolite; b: metabolic pathway KEGG analysis.
Detailed Description
The present invention will be further described with reference to the following examples. However, the scope of the present invention is not limited to the following examples. It will be understood by those skilled in the art that various changes and modifications may be made to the present invention without departing from the spirit and scope of the invention.
The instruments, reagents, materials and the like used in the following examples are conventional instruments, reagents, materials and the like in the prior art and are commercially available in a normal manner unless otherwise specified. Unless otherwise specified, the experimental methods, detection methods, and the like described in the following examples are conventional experimental methods, detection methods, and the like in the prior art.
Example 1 preparation of a herbal tea drink having anti-fatigue and appetite-improving effects
The raw material components are as follows: 600 g of cistanche powder (shanglong source), 900 g of sealwort (same benevolence hall), 600 g of sharpleaf galangal fruit (same benevolence hall), 720 g of medlar (same benevolence hall) and 720 parts of seasoning tea powder (60-mesh cooked tea fine powder).
The preparation steps are as follows:
(1) adding cistanche, polygonatum, fructus alpiniae oxyphyllae and wolfberry fruit into an ethanol solution, soaking for 0.5 hour, then carrying out reflux extraction for 2 hours, filtering, adding 12 times of ethanol solution into the dregs of a decoction, carrying out reflux extraction for 2 hours, combining the two extracting solutions, and concentrating (until the relative density is 49) to obtain a concentrated solution;
wherein the volume concentration of the ethanol solution is 50%, and the dosage of the ethanol solution is 12 times (12 times of the total weight of cistanche, polygonatum, alpinia oxyphylla and wolfberry fruit);
(2) adding the seasoned tea powder into the concentrated solution, and uniformly mixing;
(3) adding 58 g of polyvinylpyrrolidone K90, and uniformly mixing;
(4) adding sodium carboxymethylcellulose water solution (weighing 35 g of sodium carboxymethylcellulose, adding 1150mL of water to prepare water solution), and mixing;
(5) spraying 90% ethanol to make soft material, extruding, granulating, oven drying at 50 deg.C for 30min, grading with 10 mesh sieve, and removing fine powder with 60 mesh sieve.
The traditional Chinese medicine tea drink has the anti-fatigue effect, can improve the weight and the food consumption reduction of fatigue people, slow down the fatigue degree of muscles, reduce leptin secretion to improve the appetite reduction, and increase VB6 to improve the cell metabolism operation.
Animal experiment traditional Chinese medicine tea efficacy research
Healthy male C57BL/6 mice were selected for the experiment and randomized into 5 groups: a normal Control group (Control); ② chronic fatigue syndrome model group (CFS); chronic fatigue syndrome model + cistanche group (CFS + CD); fourthly, chronic fatigue syndrome model + cistanche compound group (CFS + Formula); chronic fatigue syndrome model + positive control group (CFS + Oryzanol & VB 1). The method of forced swimming is used for molding, and the molding and the administration are carried out continuously for 14 days.
Note: the medicine and the administration method of each group are as follows:
decocting cistanche deserticola with water: cistanchis herba decoction pieces are from Cistanchis herba of Shanglong Source company, and are converted into decoction for intragastric administration according to dosage of 10g per day for adults.
Cistanche compound water decoction: the self-made anti-fatigue compound (example 1) is prepared into a water decoction for stomach irrigation according to the conversion of the dosage for adults.
Positive control drug: the positive control drug is oryzanol and vitamin B1, and is converted into dosage of 30mg for each drug every day for adult, and is dissolved in double distilled water for intragastric administration.
The administration method comprises the following steps: and (3) from the 1 st d of the model building, performing intragastric administration 30min after the model building every day, wherein the intragastric administration volume is 0.1ml/10g of body weight. The Control group was drenched with the same amount of distilled water. Gavage was performed 1 time a day (q, d) for 14 days.
Weighing and calculating the food intake of each group of mice in 24 hours on the 0 th day, the 7 th day and the 14 th day of molding; and molding for 14 days to perform a fatigue rod rotating test. The comprehensive observation shows that the model has obvious influence on the weight, food intake and fatigue of each group of mice in the rod rotating device in the rod time. The overall expression is that in the modeling of the first week, the weight and the food intake of each group are not changed greatly, only the food intake of the cistanche compound group is obviously reduced, and presumably the sugar content of the cistanche compound group is higher, so that the cistanche compound group can be caused by enough satiety for animals. After the second week of molding, the weight, food intake and fatigue of the mice in the model group are obviously reduced in the rod rotating time; while the single medicine, compound medicine and positive control medicine of cistanche deserticola can reverse and reduce in different degrees, as shown in figure 1.
The detection of the appetite factors Leptin and Ghrelin in the serum discovers that the peripheral serum Leptin content of the mouse is increased and the Ghrelin content of the mouse is reduced by modeling; while cistanche deserticola single and compound herbs can reverse the rising of leptin, and have no significant effect on Ghrelin, as shown in fig. 2A and fig. 2B.
Three metabolic enzymes in serum are detected to find Na + -K + ATPase and PK have no significant difference between groups, but molding still enables the content of the two enzymes to be reduced; the SDH content of the chronic fatigue mice is obviously reduced, and the single medicine of the cistanche deserticola can reverse the situation, as shown in figure 3.
The detection of B vitamins influencing cell metabolism in urine of mice shows that the contents of VB1, VB2 and VB6 in urine of fatigue mice are all reduced, the single medicine of cistanche can reverse the reduction of VB2 and VB6, the compound has a certain treatment effect on the reduction of VB6, and the two medicines have no obvious influence on the reduction of VB1, as shown in figure 4.
Non-targeted metabonomics detection is carried out on the serum of each group of mice, and compared with a model group, the metabolic products of the cistanche single-ingredient medicine and the positive control medicine have significant difference and can be obviously distinguished, as shown in figure 5.
By taking multidimensional statistical analysis VIP & gt 1 and univariate statistical analysis P value & lt 0.05 as screening standards, 70 differential metabolites are screened out between a normal group and a model group, 74 differential metabolites are screened out between the model group and the cistanche single-drug group, and 15 total metabolites of cistanche callback are screened out by combining analysis; the metabolic pathways that these metabolites are mainly involved in are analyzed by KEGG database as purine metabolism, arginine and proline metabolism, β -alanine metabolism, glutathione metabolism, ABC transporter, bile secretion, etc., as shown in fig. 6.
The research shows that the single cistanche drug and the compound thereof can obviously improve the reduction of the weight and the ingestion of the fatigue mice, slow down the fatigue degree of muscle, reduce leptin secretion to improve the appetite, increase SDH (succinate dehydrogenase), VB2 and VB6 by the single cistanche drug to improve the cell metabolism operation, increase VB6 by the compound cistanche drug to improve the cell metabolism operation, and both the single cistanche drug and the compound thereof have good anti-fatigue effect. Through the analysis of metabolites, the anti-fatigue mechanism of the single medicine of the cistanche deserticola is probably related to the pathways of purine metabolism, arginine and proline metabolism, beta-alanine metabolism, glutathione metabolism, ABC transporter, bile secretion and the like.
Example 2 preparation of a traditional Chinese medicine tea drink having anti-fatigue and appetite-improving effects
The raw material components are as follows: 550 g of cistanche powder (shangrong source), 950 g of sealwort (same benevolence hall), 550 g of sharpleaf galangal fruit (same benevolence hall), 770 g of barbary wolfberry fruit (same benevolence hall) and 700 g of seasoning tea powder (60-mesh ripe tea fine powder).
The preparation steps are as follows:
(1) adding cistanche, rhizoma polygonati, fructus alpiniae oxyphyllae and fructus lycii into an ethanol solution, soaking for 20 minutes, then performing reflux extraction for 2.5 hours, filtering, adding 15 times of the ethanol solution into the dregs of a decoction, performing reflux extraction for 1.5 hours, combining the two extraction solutions, and concentrating to obtain a concentrated solution;
wherein the volume concentration of the ethanol solution is 45 percent, and the dosage of the ethanol solution is 15 times;
(2) adding the seasoned tea powder into the concentrated solution, and uniformly mixing;
(3) adding 62 g of polyvinylpyrrolidone K90, and mixing uniformly;
(4) adding sodium carboxymethylcellulose aqueous solution (38 g sodium carboxymethylcellulose is weighed, 1150mL water is added to prepare aqueous solution), and mixing uniformly;
(5) spraying 90% ethanol to make soft material, extruding, granulating, oven drying at 50 deg.C for 30min, grading with 10 mesh sieve, and removing fine powder with 60 mesh sieve.
Example 3 preparation of a herbal tea drink having anti-fatigue and appetite-improving effects
The raw material components are as follows: 650 g of cistanche powder (shanglong source), 850 g of sealwort (same benevolence hall), 650 g of sharpleaf galangal fruit (same benevolence hall), 670 g of medlar (same benevolence hall) and 750 g of seasoning tea powder (60-mesh cooked tea fine powder).
The preparation steps are as follows:
(1) adding cistanche, polygonatum, fructus alpiniae oxyphyllae and wolfberry fruit into an ethanol solution for soaking for 40 minutes, then carrying out reflux extraction for 1.5 hours, filtering, adding 10 times of ethanol solution into the medicine residues, carrying out reflux extraction for 2.5 hours, combining the two extraction solutions, and concentrating to obtain a concentrated solution;
wherein the volume concentration of the ethanol solution is 55 percent, and the dosage of the ethanol solution is 10 times;
(2) adding the seasoned tea powder into the concentrated solution, and uniformly mixing;
(3) adding 55 g of polyvinylpyrrolidone K90, and uniformly mixing;
(4) adding sodium carboxymethylcellulose aqueous solution (weighing 32 g of sodium carboxymethylcellulose, adding 1150mL of water to prepare aqueous solution), and mixing;
(5) spraying 90% ethanol to obtain soft material, squeezing, granulating, drying at 50 deg.C for 30min, grading with 10 mesh sieve, and removing fine powder with 60 mesh sieve.
Example 4 preparation of a Chinese medicinal tea drink having anti-fatigue and appetite-improving effects
The raw material components are as follows: 600 g of cistanche powder (shanglong source), 900 g of sealwort (same benevolence hall), 600 g of sharpleaf galangal fruit (same benevolence hall), 700 g of medlar (same benevolence hall) and 730 g of seasoned tea powder (60-mesh ripe tea fine powder).
The preparation steps are as follows:
(1) adding herba cistanches, rhizoma polygonati, fructus alpiniae oxyphyllae and fructus lycii into an ethanol solution, soaking for 30 minutes, then performing reflux extraction for 2 hours, filtering, adding 12 times of the ethanol solution into the medicine residues, performing reflux extraction for 1.5 hours, combining the two extracting solutions, and concentrating to obtain a concentrated solution;
wherein the volume concentration of the ethanol solution is 50 percent, and the dosage of the ethanol solution is 12 times;
(2) adding the flavored tea powder into the concentrated solution, and uniformly mixing;
(3) adding 60 g of polyvinylpyrrolidone K90, and uniformly mixing;
(4) adding sodium carboxymethylcellulose water solution (weighing 35 g of sodium carboxymethylcellulose, adding 1150mL of water to prepare water solution), and mixing;
(5) spraying 90% ethanol to make soft material, extruding, granulating, oven drying at 50 deg.C for 30min, grading with 10 mesh sieve, and removing fine powder with 60 mesh sieve.
The traditional Chinese medicine tea drink has the anti-fatigue effect, can improve the weight and the food consumption reduction of fatigue people, slow down the fatigue degree of muscles, reduce leptin secretion to improve the appetite reduction, and increase VB6 to improve the cell metabolism operation.
The above examples are provided to enable those of ordinary skill in the art to fully disclose and describe how to make and use the claimed embodiments, and are not intended to limit the scope of the disclosure. Modifications apparent to those skilled in the art are intended to be within the scope of the appended claims.
Claims (10)
1. A traditional Chinese medicine tea drink with the effects of resisting fatigue and improving appetite is characterized in that: the traditional Chinese medicine tea drink granule is prepared by taking cistanche, polygonatum, fructus alpiniae oxyphyllae and wolfberry fruits as raw materials and taking tea powder as an auxiliary material, wherein the dosage and the proportion relationship of the cistanche, the polygonatum, the fructus alpiniae oxyphyllae and the wolfberry fruits are as follows: 550-650 parts of cistanche powder, 850-950 parts of rhizoma polygonati, 550-650 parts of fructus alpiniae oxyphyllae and 670-770 parts of wolfberry fruit.
2. The traditional Chinese medicine tea drink with the effects of resisting fatigue and improving appetite according to claim 1, which is characterized in that: the using amount of the tea powder is 700-750 parts.
3. The traditional Chinese medicine tea drink with the effects of resisting fatigue and improving appetite according to claim 1 or 2, which is characterized in that: the dosage proportion relationship of the cistanche, the sealwort, the galangal fruit and the medlar is as follows: 600 parts of cistanche powder, 900 parts of rhizoma polygonati, 600 parts of fructus alpiniae oxyphyllae and 720 parts of wolfberry fruit; the using amount of the tea powder is 720 parts.
4. The traditional Chinese medicine tea drink with the effects of resisting fatigue and improving appetite according to claim 1, which is characterized in that: the tea powder is selected from 60 mesh cooked tea fine powder.
5. The preparation method of the traditional Chinese medicine tea drink as claimed in any one of claims 1 to 4, which is characterized by comprising the following steps: extracting Cistanchis herba, rhizoma Polygonati, fructus Alpinae Oxyphyllae and fructus Lycii with ethanol solution to obtain extractive solution, adding tea powder, adding adjuvants, and granulating.
6. The preparation method of the traditional Chinese medicine tea drink according to claim 5, which is characterized by comprising the following steps: the volume concentration of the ethanol solution is 45-55%;
the dosage of the ethanol solution is 10-15 times;
the extraction times are two, and the extraction time is 1.5-2.5 hours each time;
the auxiliary materials are selected from polyvinylpyrrolidone K90 and sodium carboxymethylcellulose.
7. The preparation method of the traditional Chinese medicine tea drink according to claim 5 or 6, which is characterized by comprising the following steps:
(1) adding cistanche, polygonatum, fructus alpiniae oxyphyllae and wolfberry fruit into an ethanol solution, soaking for 20-40 minutes, then performing reflux extraction for 1.5-2.5 hours, filtering, adding the ethanol solution into the dregs of a decoction, performing reflux extraction for 1.5-2.5 hours, combining the two extracting solutions, and concentrating to obtain a concentrated solution;
wherein the volume concentration of the ethanol solution is 45-55%, and the dosage of the ethanol solution is 10-15 times;
(2) adding tea powder into the concentrated solution, and mixing;
(3) adding polyvinylpyrrolidone K90, and mixing;
(4) adding sodium carboxymethylcellulose aqueous solution, and mixing;
(5) spraying ethanol to make soft material, extruding, granulating, oven drying, grading, and sieving to remove fine powder.
8. The preparation method of the traditional Chinese medicine tea drink according to claim 7, which is characterized by comprising the following steps: the soaking time is 30 minutes, and the reflux extraction time is 2 hours;
the volume concentration of the ethanol solution is 50%; the dosage of the ethanol solution is 12 times.
9. The use of the traditional Chinese medicine tea drink as claimed in any one of claims 1 to 4 as or in the preparation of health care products with anti-fatigue effect and/or appetite improving effect.
10. Use of the traditional Chinese medicine tea drink of any one of claims 1-4 in preparation of a medicament with anti-fatigue and/or appetite-improving effects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210254321.9A CN114916596A (en) | 2022-03-15 | 2022-03-15 | Traditional Chinese medicine tea drink with anti-fatigue effect and appetite increasing effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210254321.9A CN114916596A (en) | 2022-03-15 | 2022-03-15 | Traditional Chinese medicine tea drink with anti-fatigue effect and appetite increasing effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114916596A true CN114916596A (en) | 2022-08-19 |
Family
ID=82805747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210254321.9A Pending CN114916596A (en) | 2022-03-15 | 2022-03-15 | Traditional Chinese medicine tea drink with anti-fatigue effect and appetite increasing effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114916596A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103636839A (en) * | 2013-11-26 | 2014-03-19 | 李富玉 | Anti-fatigue tea |
| CN104605348A (en) * | 2015-01-09 | 2015-05-13 | 北京博远欣绿科技股份有限公司 | Healthcare product containing cistanche tubulosa extract and preparation method thereof |
| CN105412353A (en) * | 2015-09-11 | 2016-03-23 | 皮山御盛金茂生物科技有限公司 | Traditional Chinese medicine combination with functions of resisting senility, improving immunity, resisting fatigue and keeping healthy |
| US20180243360A1 (en) * | 2017-02-13 | 2018-08-30 | Sinphar Pharmaceutical Co., Ltd. | Anti-fatigue composition used for increasing endurance performance, and use of the same |
| CN112933203A (en) * | 2020-11-26 | 2021-06-11 | 四川烨哼健康药房有限公司 | Traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function and preparation method of traditional Chinese medicine composition |
-
2022
- 2022-03-15 CN CN202210254321.9A patent/CN114916596A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103636839A (en) * | 2013-11-26 | 2014-03-19 | 李富玉 | Anti-fatigue tea |
| CN104605348A (en) * | 2015-01-09 | 2015-05-13 | 北京博远欣绿科技股份有限公司 | Healthcare product containing cistanche tubulosa extract and preparation method thereof |
| CN105412353A (en) * | 2015-09-11 | 2016-03-23 | 皮山御盛金茂生物科技有限公司 | Traditional Chinese medicine combination with functions of resisting senility, improving immunity, resisting fatigue and keeping healthy |
| US20180243360A1 (en) * | 2017-02-13 | 2018-08-30 | Sinphar Pharmaceutical Co., Ltd. | Anti-fatigue composition used for increasing endurance performance, and use of the same |
| CN112933203A (en) * | 2020-11-26 | 2021-06-11 | 四川烨哼健康药房有限公司 | Traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function and preparation method of traditional Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 王正芳: "《实用中医保健》", 28 February 1990, 中国医药科技出版社, pages: 77 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102526478B (en) | Formula of health-care medicine with functions of strengthening immunity and reducing blood sugar | |
| CN108524814A (en) | A kind of Chinese medicine composition and preparation method thereof for reducing blood glucose | |
| CN1471953A (en) | Medicinal plant composition for treating AIDS patient | |
| CN116726112B (en) | A Chinese medicinal composition for preventing, relieving or treating debilitating syndrome, and its preparation method | |
| CN115350242B (en) | Glycolipid metabolism regulator and preparation method and application thereof | |
| CN106214846A (en) | Moringa preparation of fat and preparation method and application is adjusted in nourishing the liver | |
| CN112933203A (en) | Traditional Chinese medicine composition of medicinal liquor for resisting fatigue and improving sexual function and preparation method of traditional Chinese medicine composition | |
| CN108578544A (en) | A kind of Chinese medicine composition and the preparation method and application thereof with blood sugar reducing function | |
| CN103155985B (en) | Rhizoma polygonati nutrition powder and preparation method thereof | |
| CN102048902B (en) | Hepatitis treating traditional Chinese medicine composition, extract and preparation method, application and formulation | |
| CN103006989B (en) | Medical composition for treating diabetic nephropathy | |
| CN111110735A (en) | Lipid-lowering pharmaceutical composition, preparation method and application | |
| CN101279034B (en) | Combined Chinese medicament for curing diabetic with combined internal and external therapies and preparation thereof | |
| WO2022061978A1 (en) | Compound composition with anti-oxidation and anti-aging effects, preparation method therefor and application thereof | |
| CN114916596A (en) | Traditional Chinese medicine tea drink with anti-fatigue effect and appetite increasing effect | |
| CN107441332A (en) | The ginseng composition and preparation method of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing | |
| CN103393938B (en) | Traditional Chinese medicine composition for reducing blood sugar | |
| CN112933201A (en) | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating diabetic nephropathy and preparation method thereof | |
| CN105327115A (en) | Phellinus linteus catharsis formula for prevention and cure of type II diabetes and preparation process thereof | |
| CN110025011A (en) | A kind of Radix Ophiopogonis ginseng lozenge of strengthen immunity | |
| CN110420297A (en) | A kind of Chinese materia medica preparation for anti-trioxypurine | |
| CN106138494B (en) | Kidney nourishing composition and production method thereof | |
| CN108478701A (en) | A kind of lozenge of strengthen immunity | |
| CN114796417B (en) | Blood sugar reducing traditional Chinese medicine formula and preparation method thereof | |
| CN108686094A (en) | A kind of Traditional Chinese medicine for decreasing blood sugar and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |