CN107441332A - The ginseng composition and preparation method of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing - Google Patents
The ginseng composition and preparation method of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing Download PDFInfo
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- CN107441332A CN107441332A CN201710663511.5A CN201710663511A CN107441332A CN 107441332 A CN107441332 A CN 107441332A CN 201710663511 A CN201710663511 A CN 201710663511A CN 107441332 A CN107441332 A CN 107441332A
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to food technology field, more particularly to auxiliary adjustment endocrine metabolism and the ginseng composition of anti-cancer and cancer-preventing, there is the purposes in terms of regulation endocrine metabolism, anticancer, anti-cancer, alleviation physical fatigue, strengthen immunity, anti-aging, enhancing memory.Including 1 500 parts of ginseng, 1 500 parts of sealwort, 1 500 parts of mulberries, 1 500 parts of purslane, 1 500 parts of hoveniae semoveniae semen, 1 500 parts of radix glycyrrhizae.The composition of the present invention is accumulative to be taken through 100 patients, wherein in 42 diabetics 38 take the present composition after take a turn for the better.12 patients take stable disease after the present composition in 30 cancer patients, and remaining 28 patient significantly improves the state of mind.
Description
Technical field
The present invention relates to food technology field, and in particular to the combination of the ginseng of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing
Thing and preparation method, have in hypoglycemic, anticancer, anti-cancer, alleviate physical fatigue, strengthen immunity, anti-aging, enhancing memory
The purposes of aspect.
Background technology
Inferior health is a kind of critical condition, refers to non-sick unhealthy status, and this is a kind of inferior health status, is health and disease
State between disease.The generation of inferior health is relevant with many factors, so as to cause the nervous system of body, internal system and exempt from
Disorder that epidemic disease system total tune is unbalance.Diabetes (DM) are exactly using hyperglycaemia as principal character caused by carbohydrate metabolism disturbance
Endocrine metabolism disease.IDF（ IDF）Data are shown：2015 global diabetes adult patients up to 4.15 hundred million,
China accounts for 1.1 hundred million.China turns into the most country of diabetic in the world.So exploitation intervening sub-health state, and
The health food of prominent embodiment blood sugar reducing function is significant.
Diabetes should belong to " quenching one's thirst " category in the traditional Chinese medical science." quenching one's thirst " head is seen《Interior warp》, it is more drinks, more food, diuresis, bodies
Gradually become thin a kind of weak disease, its diagnosis and treatment is based on the scorching interpretation of the cause, onset and process of an illness of the deficiency of Yin, and the deficiency of Yin is this, scorching for mark, and the two is mutual
For cause and effect.The modern study of yin deficiency syndrome shows that deficiency of Yin person has the low characteristic of cellular immune function.《Sheng Nong's herbal classic is dredged》In
Record, the person of quenching one's thirst, the time that body fluid deficiency, gas goes back to then Tianjin and given birth to, and body fluid life is then thirsty from only.Therefore there is qi-restoratives, nourishing Yin and moistening dryness, promote the production of body fluid
Quench the thirst effect, for improving immunity, antifatigue, adjust endocrine health food and be applied to inferior health and hyperglycemia population.
The content of the invention
It is an object of the invention to provide the ginseng composition and preparation of a kind of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing
Method, blood glucose, anticancer can be effectively reduced, anti-cancer, alleviate physical fatigue, strengthen immunity, anti-aging, enhancing memory
Food compositions, its used raw material are the Chinese herbal medicine of integration of drinking and medicinal herbs, and its effect is good, quick, Small side effects.
The ginseng composition of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing, it is characterized in that its active ingredient is by following raw material
It is made：Ginseng 1-500 parts, sealwort 1-500 parts, mulberries 1-500 parts, purslane 1-500 parts, hoveniae semoveniae semen 1-500 parts, radix glycyrrhizae 1-
500 parts.Right amount of auxiliary materials.
It is preferred that ginseng composition, it is characterized in that its active ingredient is made up of following raw material：Ginseng 50-100 parts, sealwort 15-
30 parts, mulberries 15-30 parts, purslane 5-20 parts, hoveniae semoveniae semen 15-30 parts, radix glycyrrhizae 10-15 parts.Right amount of auxiliary materials.
Ginseng in the ginseng composition is fresh ginseng, sun-dried ginseng, red ginseng or other ginseng products.
Sealwort in the ginseng composition is the medicinal material or stir-baked RHIZOMA POLYGONATI with yellow rice wine for meeting standards of pharmacopoeia.
Mulberries in the ginseng composition are the medicinal material for meeting standards of pharmacopoeia.
Purslane in the ginseng composition is the medicinal material for meeting standards of pharmacopoeia.
The dry mature seed that hoveniae semoveniae semen in the ginseng composition is Rhamnaceae plant trifoliate orange Dulcis.
Radix glycyrrhizae in the ginseng composition is the medicinal material for meeting standards of pharmacopoeia.
Pharmaceutical dosage form not limited to this, by the pharmaceutical carrier commonly used on above-mentioned each medicinal raw material and pharmacy, such as excipient or auxiliary
Material can be mixed and made into tablet, capsule（Soft capsule）, granule, powder, pill, liquid preparation or other conventional formulations.
" part " used herein can be any one fix with milligram, grams or a kilogram number represent weight (such as lmg,
1g or 1kg etc.) for example, a composition being made up of 2 parts of component A and 8 parts of component B, can be 2 grams of component A and 8 grams of component B,
It can also be the composition of the compositions such as 20 grams of component A and 80 grams of component B.
Above-mentioned prescription raw material has reduction blood glucose, anticancer, anti-cancer, alleviation physical fatigue, strengthen immunity, anti-aging, increasing
The specific functions such as strong memory.Medicine is can not only be used for, can also be used as daily bread, certain regulation is played to health and is made
With raw material is also the composition of integration of drinking and medicinal herbs, can coordinate and play the effect for the treatment of both principal and secondary aspect of disease, and the function of each component medicine is respectively：
Monarch drug in a prescription-ginseng
Effect：Ginseng is Araliaceae ginseng Panax ginseng C.A.Mey. dry root and rhizome.《Legendary god of farming's book on Chinese herbal medicine
Through》Middle ginseng：It is sweet, it is slightly cold, tepor, it is nontoxic.Main tonifying five zang organs, soothe the nerves determine soul, stop palpitate with fear, remove pathogenic factor, improving eyesight, happily
Intelligence development, intestines cold in the stomach is treated, trusted subordinate rouses pain, and feeling of fullness and discomfort in the hypochondrium, cholera is told inverse, in tune, is only quenched one's thirst, promoting blood circulation, breaks hard product, makes us not
Forget, long term usage is made light of one's life by commiting suicide macrobiosis.It, which has, reinforces vital energy, veins takes off admittedly, tonifying lung benefit spleen, blood-nourishing of promoting the production of body fluid, the effect of tranquilize the mind and promote the intelligence.
Pharmacological action：Enhancing memory that ginseng has, immunity is improved, improves angiocarpy, anti-aging, divide in regulation
Secrete, antifatigue and antitumor etc. multiple pharmacological effect.
Ministerial drug-sealwort
Effect：Sealwort is the dry rhizome of liliaceous plant sealwort, P. kingianum, David's-harp and polygonatum filipes, and sealwort is eaten for medicine
Dual-purpose product,《Compendium of Materia Medica》Recording sealwort, " sweet, flat, nontoxic, tonifying middle-Jiao and Qi, curing rheumatism, five viscera settling, long term usage make light of one's life by commiting suicide macrobiosis not
It is hungry.General debility is mended, helps muscles and bones, resistance to cold and heat, Energy benefit taste, embellish lung.All void is mended, only fever and chills, replenishing essence marrow, lower three chi worms ",《In
State's pharmacopeia》Record：Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.
Pharmacological action：Modern pharmacological research shows that sealwort has regulation blood glucose, anti-aging, immunological regulation, antitumor and antibacterial etc.
Effect.
Ministerial drug-mulberry fruit
Effect：Mulberry fruit is moraceae plants mulberry Morus alba L. drying fruit ear.Before more than 2,000 years, mulberries have been China
The hired tonic of emperor.Mulberries both can food, can be used as medicine again,《Compendium of Materia Medica》Recording mulberry fruit, " single food, is only quenched one's thirst, and relieving the five internal organs is closed
Section, lead to vim and vigour, long term usage is not hungry, spirit sedation, makes us clever, bleaches not old.”《Chinese Pharmacopoeia》Description：Mulberry fruit, sweet acid, property
It is slightly cold, enters the heart, liver and kidney channel, there is the effect of nourishing yin and supplementing blood, fluid dryness.
Mulberries are always the conventional yin tonics of tcm clinical practice, cure mainly syndrome of yin deficiency of liver and kidney.Diabetes spp is in the traditional Chinese medical science " quenching one's thirst " disease
Category, and the basic pathogenesis of diabete be the deficiency of Yin it is scorching.
Pharmacological action：Modern pharmacological research shows that mulberries have good hypoglycemic and lipid-loweringing, anti-oxidant, strengthen immunity, resisted
The effect such as cancer and anti-mutation.
Adjutant-purslane
Effect：Purslane is Herba portulacae section plant purslane Portulaca oleracea L. dry aerial parts.Purslane
For medical and edible dual purpose plant,《Classified Materia Meidca》Record：Purslane, it is sour, tremble with fear, it is nontoxic.Argument is blind, nebula, sharp stool and urine, cold removing
Heat, kill parasites.The , Po Disorder that quench the thirst knots, ulcerative carbuncle.Subside a swelling with scattered blood, sharp intestines habitual abortion, detoxify treating stranguria, abnormal sweating after managing property.The effect of.
Pharmacological action：Modern pharmacological research shows that purslane has hypoglycemic and reducing blood lipid, anti-oxidant, antibacterial, antitumor
Etc. a variety of functions.
Adjutant-hoveniae semoveniae semen
Hoveniae semoveniae semen is Rhamnaceae plant trifoliate orange Dulcis fruits and seedses.Li Shizhen (1518-1593 A.D.)《Compendium of Materia Medica》Be recited as " it is sweet, mild-natured, nontoxic,
There is relieving restlessness of quenching the thirst, remove hot on diaphragm, moisturizing viscera, sharp stool and urine, the same honey of work(".
Pharmacological action：Hoveniae semoveniae semen, which has, significantly to relieve the effect of alcohol and liver protection, anti-hepatic fibrosis and anti-aging, fatigue-resisting function.
Make medicine-radix glycyrrhizae
Effect：Radix glycyrrhizae is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root and rhizome.Radix glycyrrhizae is planted for medicine-food two-purpose
Thing, beam is for Tao Hongjing《Mingyi Bielu》Record：Radix glycyrrhizae is " nontoxic.Main middle benefit gas, lower gas, dysphoria, loses heart, and wound is dirty, cough, quenches the thirst, and leads to
Passages through which vital energy circulates, sharp vim and vigour, hundred medicines of solution poison ".Li Shizhen (1518-1593 A.D.)《Compendium of Materia Medica》Record：Radix glycyrrhizae, mends general debility, all are deficient, all empty and more
Hot person, which adds, uses it.Classical Chinese medicine prescription often uses this product coordinating the drug actions of a prescription.
Pharmacological action：Modern pharmacological research shows that radix glycyrrhizae has that antiviral, regulation is immune, anti-aging, anti-arrhythmia, anti-
The multiple efficacies such as scorching and antitumor.
In summary, the pharmacological action of each medicinal material in the present composition is shown, the present invention has regulation endocrine generation
Thank, anticancer, anti-cancer, alleviate physical fatigue, strengthen immunity, anti-aging, the enhancing function such as memory.
The invention provides the ginseng composition preparation method of a kind of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing, and it is special
Sign is that described method includes step:
1st, raw material weighed, screened, being cleaned, crush it is standby.
2nd, the extraction of ginseng extract is with refining.
（1）The ginseng raw material of crushing is added 5-10 times by prescription actual ratio and measures 60-80% ethanol extraction 2-4 times, every time
1-2 hours, filtering, alcohol extract recovery ethanol, the dregs of a decoction add the 6-10 times of water measured, extracted 2-4 times, each 1-2 hours, filtering
With merging alcohol extracting concentrate, appropriate biology enzyme is added（Such as beta galactosidase, pectase, amyloglucosidase and
Its mixed enzyme）Carry out bioenzymatic conversion.Below control ph 6.0, control below temperature 50 C, question response is concentrated into rule after terminating
Determine density, it is standby.It is using enzyme catalyst benefit：Bioenzymatic conversion technology, using enzyme as catalyst, efficiently, optionally
Catalysis ginsenoside is converted into the rare saponin(e with high activity.Before the rare saponin of ginseng has high medical value and application
Scape because content of the rare saponin in red ginseng and wild ginseng there was only 100,000/it is several, bioenzymatic conversion technology is by changing people
The glycosyl of the higher glycols of content and three alcohols saponins in ginseng, it is allowed to orientation and is converted into the rare saponin of ginseng.
Or（2）The ginseng raw material of crushing is added 5-10 times by prescription actual ratio and measures 60-80% ethanol extraction 2-4
It is secondary, each 1-2 hours, filtering, alcohol extract recovery ethanol, the dregs of a decoction 6-10 times of water measured of addition, extract 2-4 times, each 1-2 is small
When, filtering, and merge alcohol extract, for control ph below 6.0, normal pressure is concentrated into regulation density, standby.
Or（3）The ginseng raw material of crushing is added 5-10 times by prescription actual ratio and measures 60-80% ethanol extraction 2-4
It is secondary, each 1-2 hours, filtering, alcohol extract recovery ethanol, the dregs of a decoction 6-10 times of water measured of addition, extract 2-4 times, each 1-2 is small
When, filtering, and merge alcohol extract, control ph is below 6.0, after normal pressure is concentrated into regulation density, is carried out in more than 100 DEG C high
It is standby after warm question response terminates.
Or（4）The ginseng raw material of crushing is added 5-10 times by prescription actual ratio and measures 60-80% ethanol extraction 2-4
It is secondary, each 1-2 hours, filtering, alcohol extract recovery ethanol, the dregs of a decoction 6-10 times of water measured of addition, extract 2-4 times, each 1-2 is small
When, filtering, and merge alcohol extract, after being concentrated into regulation density, control ph 8.0-12, high temperature, height are carried out in more than 100 DEG C
30-40min is pressed, it is standby after question response terminates.
Or（5）The ginseng raw material of crushing is put into Steam explosive machine, 70-250 DEG C of temperature of control, pressure 0.2-8MPa, when
Between be 1-30min, discharging it is standby.The ginseng raw material of steam explosion is added 5-10 times by prescription actual ratio and measures the extraction of 60-80% ethanol
2-4 times, each 1-2 hours, filtering, alcohol extract recovery ethanol, the dregs of a decoction 6-10 times of water measured of addition, extract 2-4 times, each 1-
2 hours, filter and merge alcohol extracting concentrate, be concentrated into regulation density, it is standby.
The advantage of steam explosion：（1）Steam explosion is the processing material in the case where that need not add the water vapor conditions of any chemical reagents
Technology, it is a kind of without sewage discharge, free of contamination clean method applied to aglycon is extracted from plant material；（2）With processing
Time is short, efficiency high, reduces the characteristics of being degraded to active material；（3）Steam explosion goes glycosidic bond to add acid, alkali and enzyme system
Agent, reduce reagent or enzyme preparation cost.
3rd, will be in addition to ginseng, the raw material of other crushing adds 6-10 times by prescription actual ratio and measures 40-70% ethanol extraction 2-
4 times, each 1-2 hours, filtering, alcohol extract recovery ethanol；The dregs of a decoction add the 6-10 times of water measured, and extract 2-4 times, each 1-2
Hour, filtering；Merge alcohol extract, concentration regulation density.
4th, two kinds of concentrates made of 2 and 3 are merged, addition prepares various customary adjuvants required during different dosage forms, such as
Diluent, disintegrant, adhesive, lubricant, filler, preservative, flavouring, stabilizer, surfactant etc., with routine
Any conventional peroral dosage form is made in medicine formulation method, such as tablet, capsule, pill, powder, syrup, tincture, oral
Solution, emulsion, supensoid agent, mixture, soft extract, vina, medicinal tea, liquid extract and extract etc..
Biology enzyme employed in the preparation method of composition provided by the invention can be that one kind can also be a variety of groups
Synthase.The species of enzyme is any biology enzyme that there is catalysis ginsenoside to be converted into rare ginsenoside.Biology enzyme such as β-gala
Glycosidase, 1,4 beta-glucanase, amyloglucosidase etc. and its mixed enzyme.
The ginseng composition preparation method of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing, it is characterized in that step is as follows：
(1) raw material weighed, screened, being cleaned, crush it is standby.
(2) extraction of ginseng extract is with refining.
A, the ginseng raw material of crushing is put into Steam explosive machine, controls 70-250 DEG C of temperature, pressure 0.2-8MPa, time 1-
30min, discharging are standby.
B, the ginseng raw material of steam explosion is added 5-10 times by prescription actual ratio and measures 60-80% ethanol extraction 2-4 times, every time
1-2 hours, filtering, alcohol extract recovery ethanol, the dregs of a decoction add the 6-10 times of water measured, extracted 2-4 times, each 1-2 hours, filtering
With merging alcohol extracting concentrate, regulation density is concentrated into, it is standby.
(3) will be in addition to ginseng, the raw material of other crushing adds the 6-10 times of water measured by prescription actual ratio, extracts 2-4 times,
Each 1-2 hours, filtering；The dregs of a decoction add 6-10 times and measure 40-70% ethanol extraction 2-4 times, each 1-2 hours, filtering, alcohol extracting
Liquid reclaims ethanol and merges Aqueous extracts, concentration regulation density.
(4) two kinds of concentrates made of step (2) and step (3) are merged, addition prepares required each during different dosage forms
Medicament is made in kind customary adjuvant.
The present invention starts with from theory of traditional Chinese medical science, and Six-element medicinal material is total to using ginseng, sealwort, purslane, mulberries, hoveniae semoveniae semen, radix glycyrrhizae,
Through reasonable compatibility, developing a have regulation endocrine metabolism, anticancer, anti-cancer, alleviates physical fatigue, be strengthen immunity, anti-
Aging, the function of strengthening memory, aid in the ginseng food of sub-health treatment.
Advantages of the present invention：
1st, traditional Chinese medicine thinks that many malaise symptoms performance of sub-health state and psychological experiences are the negative and positive of body, internal organs, qi and blood
Imbalance state.The present invention starts with from theory of traditional Chinese medical science, using qi and blood and controls, the method for conditioning viscera, with Chinese medicine monarch, minister, helps, makes
Combination principle and simultaneously using both cold and hot drugs medicine compatibility method, fully demonstrated the basic characteristics and eliminating pathogen to support vital qi, tune of differentiation of tcm
Manage the basic rules for the treatment of of negative and positive.
2nd, composition of the invention has the effect of qi-blood tonifying, supplementing qi and nourishing yin.It, which is treated, is reinforced vital energy with ginseng, answers arteries and veins
Prevent prolapse, nourishing qi to stop are monarch, are equipped with sealwort boosting qi and nourishing yin, invigorating the spleen moistening lung, and mulberry fruit nourishing yin and supplementing blood, fluid dryness are altogether minister, help with
Purslane is subsided a swelling, and is quenched the thirst, and hoveniae semoveniae semen quenches the thirst relieving restlessness, and with radix glycyrrhizae mediation property of medicine, is made qi and blood and controlled, supplementing qi and nourishing yin, help to change
Kind blood flow, hypoglycemic, antifatigue, anti-aging, the gas of the true strength of wake-up life.
3rd, the traditional Chinese medical science thinks that sub-health state is mostly asthenic symptoms, mainly in close relations with the five internal organs.Controlling for conditioning viscera should be used
Treatment method.Ginseng, sealwort returns spleen, lung, the heart, kidney channel in the composition of the present invention, invigorate the spleen and benefit qi；Mulberry fruit, purslane enter the heart, liver,
Kidney channel, liver-kidney tonifying；Hoveniae semoveniae semen enters stomach, moisturizing viscera, sharp stool and urine.The radix glycyrrhizae thoughts of returning home, lung, spleen, stomach, QI invigorating reconcile with
All medicines.Six medicines coordinate, and play replenish qi to invigorate the spleen altogether, the work(of liver-kidney tonifying, reach the purpose of conditioning the five internal organs.
4th, composition of the invention uses the medicine compatibility method of fever and chills mutual aid.In composition with mulberry fruit cold in nature and Herba portulacae with
The warm of assistant ginseng processed, this measure can restrict the property fluid dryness of the temperate-dryness of ginseng, and and can, which is help others, joins nourishing yin and supplementing blood, embodies
The reasonable compatibility of fever and chills and warm medicine of a cold nature thing, organically combine, reach bidirectional modulation, balance coordination, so that the property of medicine of full side is more
It is gentle.
5th, people is participated in sealwort, purslane, mulberries, hoveniae semoveniae semen, radix glycyrrhizae group by the present invention based on the pharmacological research in modern times
Close.Modern pharmacological research confirms that there is the medicinal material in above-mentioned prescription reduction blood glucose, anticancer, anti-cancer, alleviation physical fatigue, enhancing to exempt from
The functions such as epidemic disease power, anti-aging, enhancing memory.And be the article of integration of drinking and medicinal herbs, medicine is can not only be used for, can also be used as day to often eat
Product, certain adjustment effect is played to health, can coordinate and play the effect for the treatment of both principal and secondary aspect of disease.
6th, production technology of the present invention is using bioenzymatic conversion technology, steam explosion technology, sour hydrolysis, basic hydrolysis conversion, height
The methods of warm high pressure, effectively be catalyzed ginsenoside be converted into rare ginsenoside Rg3, Rg5 with high activity, CK, Rh1,
Rh2 and Rh3 etc..The rare saponin content of ginseng after being handled using process above is increased by 500 the above.The rare saponin of ginseng has pole
High medical value and application prospect because content of the rare saponin in red ginseng and wild ginseng there was only 100,000/it is several, by with
Upper transformation technology changes the glycosyl of the higher glycols of content and three alcohols saponins in ginseng, is allowed to orientation and is converted into the rare soap of ginseng
Glucoside.The rare saponin of ginseng has very high physiologically active；As panaxoside Rh1, Rh2, Rh3 and Rg3 have anticancer, intelligence development, exempts from
Epidemic disease adjusts and anti-cerebral ischemia, neurocyte protection act on.So as to strengthen the anticancer of the present composition, anti-cancer, enhancing memory,
The effect of strengthen immunity.
7th, composition of the invention is accumulative takes through 100 patients, wherein in 42 diabetics 38 take the present invention
Taken a turn for the better after composition.12 patients take stable disease after the present composition in 30 cancer patients, and remaining 28 patient is bright
It is aobvious to improve the state of mind.
Embodiment:
The present invention will be further elaborated by following examples by the present invention, it is not limited to this.
Embodiment 1：The ginseng composition and preparation method-oral liquid of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing
The dosage of medicine each component of the present invention can be:Ginseng 50g, sealwort 15g, purslane 5g, mulberries 15g, hoveniae semoveniae semen 15g,
Radix glycyrrhizae 10g；Its preparation method is:Raw material is weighed, screened, crush it is standby；The ginseng raw material of crushing is actual by prescription
8 times of 80% ethanol of amount of ratio addition extract 2 times, and 1 hour every time, filtering, alcohol extract reclaimed ethanol, 7 times of amounts of dregs of a decoction addition
Water, extract 2 times, 2 hours every time, filtering, and merging alcohol extract, the amyloglucosidase for adding 0.5U/mL carried out biology
Enzymatic conversion, it is concentrated into regulation density.Will be in addition to ginseng, the raw material of other crushing adds 6 times of 40% ethanol of amount by prescription actual ratio
Extraction 3 times, 1.5 hours every time, filtering, alcohol extract recovery ethanol, the water of the dregs of a decoction 9 times of amounts of addition, extract 2 times, 1 is small every time
When, filtering；With merging alcohol extract, concentration regulation density.Will made of 2 kinds of condensed creams add flavourings, stabilizer, diluent and
Water, filling, sterilizing can be prepared by oral liquid.
Embodiment 2：The ginseng composition and preparation method-capsule of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing
The dosage of medicine each component of the present invention can be:Ginseng 100g, sealwort 25g, purslane 20g, mulberries 25g, hoveniae semoveniae semen
25g, radix glycyrrhizae 15g；Its preparation method is：Raw material is weighed, screened, crushes standby ginseng raw material's input steam explosion by crushing
In machine, 150 DEG C, pressure 4MPa, time 10min of temperature is controlled, is discharged standby.The ginseng raw material of steam explosion is pressed into the actual ratio of prescription
7 times of 80% ethanol of amount of example addition extract 2 times, 1.2 hours every time, filter, alcohol extract recovery ethanol, 10 times of amounts of dregs of a decoction addition
Water, extract 2 times, 1.5 hours every time, filtering, merge alcohol extracting concentrate, be concentrated into regulation density, it is standby.Will in addition to ginseng,
The raw material of other crushing adds 6 times of 50% ethanol of amount by prescription actual ratio and extracted 2 times, and 1 hour every time, filtering, alcohol extract returned
Receive ethanol；The dregs of a decoction add the water of 10 times of amounts, extract 2 times, 1 hour every time, filter；Merge alcohol extract, concentration regulation density.Will system
Into 2 kinds of condensed creams add diluent, filler, glidant etc. particle be made, be filled with capsule and can be prepared by capsule.
Embodiment 3：The ginseng composition and preparation method-tablet of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing
The dosage of medicine each component of the present invention can be:Ginseng 90g, sealwort 30g, purslane 20g, mulberries 30g, hoveniae semoveniae semen
30g, radix glycyrrhizae 10g；Its preparation method is：Raw material is weighed, screened, crush it is standby；The ginseng raw material of crushing is pressed into prescription
Actual ratio adds 6 times of 50% ethanol of amount and extracted 2 times, and 2 hours every time, filtering, alcohol extract reclaimed ethanol, and the dregs of a decoction add 8 times of amounts
Water, extract 2 times, 1.2 hours every time, filtering, merge alcohol extracting concentrate, control ph is below 6.0, and it is close to be concentrated into regulation
Degree, it is standby.Will be in addition to ginseng, the raw material of other crushing adds 7 times by prescription actual ratio and measures 60% ethanol extraction 2 times, every time
1.5 hours, filtering, alcohol extract recovery ethanol, the water of the dregs of a decoction 8 times of amounts of addition, extraction 2 times, 1 hour every time, filtering；Merge alcohol
Extract solution, concentration regulation density.2 kinds of concentrates merge by made of.Manufactured condensed cream is added into adhesive, filler, profit
Lubrication prescription, glidant, being prepared according to Chinese medicine preparation conventional method turns into tablet.
Embodiment 4：The ginseng composition and preparation method-capsule of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing
The dosage of medicine each component of the present invention can be:Ginseng 100g, sealwort 25g, purslane 20g, mulberries 25g, hoveniae semoveniae semen
25g, radix glycyrrhizae 15g；Its preparation method is:Raw material is weighed, screened, crush it is standby；The ginseng raw material of crushing is pressed into prescription
Actual ratio adds 8 times of 80% ethanol of amount and extracted 2 times, and 1 hour every time, filtering, alcohol extract reclaimed ethanol, and the dregs of a decoction add 7 times of amounts
Water, extract 2 times, 2 hours every time, filtering, and merge alcohol extract, the amyloglucosidase for adding 0.5U/mL given birth to
Thing enzymatic conversion, it is concentrated into regulation density.Will be in addition to ginseng, the raw material of other crushing adds 6 times of 40% second of amount by prescription actual ratio
Alcohol extracting 3 times, 1.5 hours every time, filtering, alcohol extract recovery ethanol, the water of the dregs of a decoction 9 times of amounts of addition, extract 2 times, 1 is small every time
When, filtering；Merge alcohol extract, concentration regulation density.2 kinds of condensed creams add the system such as diluent, filler, glidant by made of
Into particle, it is filled with capsule and can be prepared by capsule.
Embodiment 5：The ginseng composition and preparation method-capsule of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing
The dosage of medicine each component of the present invention can be:Ginseng 100g, sealwort 25g, purslane 20g, mulberries 25g, hoveniae semoveniae semen
25g, radix glycyrrhizae 15g；Its preparation method is：Raw material is weighed, screened, crush it is standby；The ginseng raw material of crushing is pressed into prescription
Actual ratio adds 6 times of 50% ethanol of amount and extracted 2 times, and 2 hours every time, filtering, alcohol extract reclaimed ethanol, and the dregs of a decoction add 8 times of amounts
Water, extract 2 times, 1.2 hours every time, filtering, merge alcohol extracting concentrate, control ph is below 6.0, and it is close to be concentrated into regulation
Degree, it is standby.Will be in addition to ginseng, the raw material of other crushing adds 7 times by prescription actual ratio and measures 60% ethanol extraction 2 times, every time
1.5 hours, filtering, alcohol extract recovery ethanol, the water of the dregs of a decoction 8 times of amounts of addition, extraction 2 times, 1 hour every time, filtering；Merge
Alcohol extract, concentration regulation density.Manufactured 2 kinds of condensed creams are added into diluent, filler, glidant etc. particle is made, be filled with
Capsule can be prepared by capsule.
The third aspect of the present invention, there is provided a kind of purposes of composition provided by the invention as described above, its feature
It is to be used as or for adjusting endocrine metabolism, anticancer, anti-cancer, alleviation physical fatigue, strengthen immunity, anti-aging, enhancing note
Recall the purposes in terms of power.
Experimental example 1
The composition of the present invention is accumulative to be taken through 100 patients, wherein in 42 diabetics 38 take the present composition
After take a turn for the better.12 patients take stable disease after the present composition in 30 cancer patients, and remaining 28 patient is obviously improved
The state of mind.
Experimental example 2
The content balance of rare ginsenoside in the sample that different production technologies is produced.
In summary, the present composition has hypoglycemic, anticancer, anti-cancer, alleviates physical fatigue, strengthen immunity, resists
Aging, the food and health products for strengthening memory function, definite effect.
Claims (6)
1. the ginseng composition of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing, it is characterized in that its active ingredient is by following raw material system
Into：Ginseng 1-500 parts, sealwort 1-500 parts, mulberries 1-500 parts, purslane 1-500 parts, hoveniae semoveniae semen 1-500 parts, radix glycyrrhizae 1-500
Part.
2. the ginseng composition of auxiliary adjustment endocrine metabolism according to claim 1 and anti-cancer and cancer-preventing, it is characterized in that its
Active ingredient is made up of following raw material：Ginseng 50-100 parts, sealwort 15-30 parts, mulberries 15-30 parts, purslane 5-20 parts, trifoliate orange Dulcis
Sub- 15-30 parts, radix glycyrrhizae 10-15 parts.
3. the ginseng composition of auxiliary adjustment endocrine metabolism according to claim 1 or 2 and anti-cancer and cancer-preventing, it is characterized in that
Oral liquid is made by following raw material in its active ingredient：It is ginseng 50g, sealwort 15g, purslane 5g, mulberries 15g, hoveniae semoveniae semen 15g, sweet
Careless 10g.
4. the ginseng composition of auxiliary adjustment endocrine metabolism according to claim 1 or 2 and anti-cancer and cancer-preventing, it is characterized in that
Capsule is made by following raw material in its active ingredient：It is ginseng 100g, sealwort 25g, purslane 20g, mulberries 25g, hoveniae semoveniae semen 25g, sweet
Careless 15g.
5. the ginseng composition of auxiliary adjustment endocrine metabolism according to claim 1 or 2 and anti-cancer and cancer-preventing, it is characterized in that
Tablet is made by following raw material in its active ingredient：Ginseng 90g, sealwort 30g, purslane 20g, mulberries 30g, hoveniae semoveniae semen 30g, radix glycyrrhizae
10g。
6. the ginseng composition preparation method of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing, it is characterized in that step is as follows：(1) it is right
Raw material weighed, screened, being cleaned, it is standby to crush；
(2) extraction of ginseng extract is with refining；
A, the ginseng raw material of crushing is put into Steam explosive machine, controls 70-250 DEG C of temperature, pressure 0.2-8MPa, time 1-
30min, discharging are standby；
B, the ginseng raw material of steam explosion is added 5-10 times by prescription actual ratio and measures 60-80% ethanol extraction 2-4 times, each 1-2 is small
When, filtering, alcohol extract recovery ethanol, the dregs of a decoction 6-10 times of water measured of addition, extract 2-4 times, each 1-2 hours, filter and close
And alcohol extracting concentrate, regulation density is concentrated into, it is standby；
(3) will be in addition to ginseng, the raw materials of other crushing adds the 6-10 times of water measured by prescription actual ratio, extracts 2-4 times, every time
1-2 hours, filtering；The dregs of a decoction add 6-10 times and measure 40-70% ethanol extraction 2-4 times, each 1-2 hours, filtering, alcohol extract time
Receive ethanol and merge Aqueous extracts, concentration regulation density；
(4) two kinds of concentrates made of step (2) and step (3) are merged, addition prepare during different dosage forms it is required it is various often
Medicament is made in rule auxiliary material.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210871731.8A CN115089661A (en) | 2017-08-05 | 2017-08-05 | Application of ginseng composition for assisting in regulating endocrine metabolism and resisting and preventing cancer |
| CN201710663511.5A CN107441332A (en) | 2017-08-05 | 2017-08-05 | The ginseng composition and preparation method of auxiliary adjustment endocrine metabolism and anti-cancer and cancer-preventing |
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Cited By (2)
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| CN107927096A (en) * | 2018-01-23 | 2018-04-20 | 思朗食品（淮北）有限公司 | Biscuit of hypoglycemia generation value that suitable diabetic population is eaten and preparation method thereof |
| CN108850377A (en) * | 2018-09-27 | 2018-11-23 | 河南红丽桦医药科技有限公司 | A kind of natural traditional Chinese medicine health preserving tea and preparation method thereof |
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| CN107927096A (en) * | 2018-01-23 | 2018-04-20 | 思朗食品（淮北）有限公司 | Biscuit of hypoglycemia generation value that suitable diabetic population is eaten and preparation method thereof |
| CN108850377A (en) * | 2018-09-27 | 2018-11-23 | 河南红丽桦医药科技有限公司 | A kind of natural traditional Chinese medicine health preserving tea and preparation method thereof |
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Effective date of registration: 20210127 Address after: 134000 17-20 Wenhua East Road, Ji'an City, Tonghua City, Jilin Province Applicant after: JILIN JI'AN YISHENG PHARMACEUTICAL Co.,Ltd. Address before: 134200 no.17-20 Wenhua East Road, Ji'an City, Tonghua City, Jilin Province Applicant before: Liu Jianming |
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Application publication date: 20171208 |