CN103989996B - It is a kind of to treat Chinese medicine composition of diabetes and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating diabetes, it is made up of the raw material of following parts by weight：25 35 parts of the Radix Astragali, 20 30 parts of the root of herbaceous peony, 15 20 parts of the wind-weed, 12 16 parts of Poria cocos, 12 16 parts of sealwort, 5 10 parts of the tuber of dwarf lilyturf, 5 10 parts of stringy stonecrop, 5 10 parts of wolf's milk, dragon-boat spends 5 10 parts, 5 10 parts of Chinese trumpet creeper, 5 10 parts of caulis bambusae in taenian, 48 parts of dens draconis, 48 parts of Rabdosia rubescens, 36 parts of Caulis Kadsurae, 8 10 parts of Radix Glycyrrhizae.The preparation method of the Chinese medicine composition is also disclosed, the Chinese medicine composition for the treatment of diabetes of the invention is pure Chinese medicinal preparation, has significant curative effect, no obvious toxic-side effects to the diabetes triggered by endocrinopathy；The medicine for overcoming traditional treatment diabetes largely uses antidiabetic drug and insulin, and cost is higher, the problem of using larger to human body side effect for a long time；Instant effect, determined curative effect, medicine source is extensively, with low cost；Effective percentage up to 92%, complication rate is small, treats both principal and secondary aspect of disease, and long-term effect is good.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for treating diabetes and preparation method thereof.
Background technology
Diabetes are a kind of common endocrine system diseases, are due to the absolute shortage or relative deficiency of internal insulin, or
Insulin quality itself and other reasonses cause it normally to play physiological action, caused by sugar based on glycometabolism
The disorderly a kind of syndrome of class, lipid, the big metabolism of protein three.Clinical manifestation is diuresis, many drinks, many foods, is become thin, i.e.,
" three-many-one-little " symptom.
The traditional Chinese medical science thinks that diabetes are mainly due to the ferritic deficiency of Yin, and the five internal organs are weak, multiple because of eating and drinking without temperance, overfeeding delicious food, feelings will
Imbalance, labor is intended to excessively, and causes deficiency of kidney-YIN, and lung stomach is scorching；Interpretation of the cause, onset and process of an illness emphasis is that the deficiency of Yin is scorching, using the deficiency of Yin as this, scorching for mark；
With the passing of time disease prolongs, yin deficiency affecting yang, deficiency in both YIN and YANG.
The medicine of the diabetes for the treatment of treatment at present is broadly divided into three classes, and one is with insulin sensitizer, sulfonylureas, biguanides
With the Western medicine preparation based on alpha-glucosidase inhibitor, the advantage of this kind of medicine is that hypoglycemic is rapid, and effect is notable, but side effect is bright
Show, and most oral drugs are unsuitable for hepatic and kidney function obstacle patient and used, and Patient drug's secondary failure can be caused；Two are
Contain western medicine composition in the pharmaceutical preparation of Integrated TCM, such medicine, there is side effect to hepatic and renal function, long-term taking is to body
Body harm is larger；Three be pure Chinese medicinal preparation, and side effect of such medicine to human body is smaller, can integrally improve the symptom of patient,
But there have some pure Chinese medicinal preparations to work to be relatively slow, and action effect is not notable.
The content of the invention
The purpose of the present invention is that there is provided a kind of good effect, safe without toxic side effect to overcome above-mentioned the deficiencies in the prior art
The Chinese medicine composition for the treatment of diabetes and preparation method thereof.
To achieve the above object, the present invention uses following technical proposals：
A kind of Chinese medicine composition for treating diabetes, is made up of the bulk drug of following parts by weight：
25-35 parts of the Radix Astragali, 20-30 parts of the root of herbaceous peony, 15-20 parts of the wind-weed, 12-16 parts of Poria cocos, 12-16 parts of sealwort, tuber of dwarf lilyturf 5-10
Part, 5-10 parts of stringy stonecrop, 5-10 parts of wolf's milk, 5-10 parts of dragon-boat flower, 5-10 parts of Chinese trumpet creeper, 5-10 parts of caulis bambusae in taenian, 4-8 parts of dens draconis,
4-8 parts of Rabdosia rubescens, 3-6 parts of Caulis Kadsurae, 8-10 parts of Radix Glycyrrhizae.
The Chinese medicine composition of the treatment diabetes of the present invention, prescription preferably is：
30 parts of the Radix Astragali, 25 parts of the root of herbaceous peony, 18 parts of the wind-weed, 14 parts of Poria cocos, 14 parts of sealwort, 8 parts of the tuber of dwarf lilyturf, 8 parts of stringy stonecrop, wolf's milk
8 parts, dragon-boat spends 6 parts, 6 parts of Chinese trumpet creeper, 6 parts of caulis bambusae in taenian, 6 parts of dens draconis, 6 parts of Rabdosia rubescens, 5 parts of Caulis Kadsurae, 9 parts of Radix Glycyrrhizae.
The formula of the present invention is according to China's theory of TCM, with reference to the clinical research of inventor for many years, traditional Chinese medicine
Macroscopic syndrome opinion control the Empirical formula drawn with the refined diagnosis Technology application of modern medicine into clinical experimental study.According to
Theory of traditional Chinese medical science, for the pathogenesis of diabetes, carries out dialectical composition of prescription, " asthenic symptoms " is based oneself upon, qi-restoratives is consolidated, to reach sample
The simultaneous purpose controlled.
In medicament composing prescription, the Radix Astragali, the root of herbaceous peony, the wind-weed, Poria cocos, sealwort, the tuber of dwarf lilyturf, stringy stonecrop, wolf's milk, Chinese trumpet creeper, caulis bambusae in taenian, winter
Grass is insulted, Caulis Kadsurae, the taste medicinal material of Radix Glycyrrhizae 13 is《Chinese Pharmacopoeia》Version (one) kind for recording in 2010, its quality meets
Relevant every regulation under each kind；Dragon-boat is spent, and the taste medicine of dens draconis 2 is《Genunie medicinal materials figure allusion quotation》(Fujian science and technology is published
Society) kind recorded, its quality meets every regulation relevant under each kind.
Wherein, the Radix Astragali：With strengthening the body resistance to consolidate the constitution, the effect of tonifying middle-Jiao and Qi, contain polysaccharide, glycosides, flavones and micro member in the Radix Astragali
The Multiple components such as element, have extensive effect to human endocrine system, nervous system.
The root of herbaceous peony：With nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, effect of suppressing liver-YANG.For blood deficiency chlorosis, menstruation
It is uncomfortable, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, four limbs contraction bitterly, dizziness of having a headache.
The wind-weed：With clearing heat-fire, the effect of nourishing Yin and moistening dryness.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung-heat type cough, hectic fever due to yin
Hectic fever, Heat Diabetes, restlessness of asrhenia type and insomnia.
Poria cocos：It is sweet, light, put down.The thoughts of returning home, lung, spleen, kidney channel.With clearing damp and promoting diuresis, invigorating the spleen, effect of calming heart.
Sealwort:It is sweet, put down.Returns spleen, lung, kidney channel.With boosting qi and nourishing yin, invigorating the spleen, moistening lung, effect of kidney-nourishing.For taste
The deficiency of vital energy, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis,
Heat Diabetes.
The tuber of dwarf lilyturf：With nourishing Yin and promoting production of body fluid, effect of moistening lung clears away heart-fire.For dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, Tianjin wound
It is thirsty, Heat Diabetes, vexed insomnia, dry constipation of intestines.
Stringy stonecrop：It is sweet, light, it is cool.Return liver, courage, small intestinl channel.With removing dampness through diuresis and removing jaundice, clearing heat and detoxicating effect.For damp and hot
Jaundice, difficult urination, carbuncle swells sore.
Wolf's milk：With clearing heat and detoxicating, cooling blood and hemostasis, effect of removing dampness through diuresis and removing jaundice.For dysentery, diarrhea is spat blood, hematuria,
Have blood in stool, uterine bleeding, boil carbuncle swells, jaundice with damp-heat pathogen.
Dragon-boat is spent：It is cool in nature, it is sweet, pungent.With promoting blood circulation for regulating menstruation, effect of dissipate stasis of blood hemostasis, for hypertension, irregular menstruation,
The diseases such as injured bones and muscles.
Chinese trumpet creeper：Sweet, acid, trembles with fear.Return liver, pericardium channel.With invigorate blood circulation, effect of cooling blood, expelling wind.For menstruation not
Adjust, Jing Bi Disorder lumps in the abdomen, postpartum breast is swollen, and rubella is rubescent, pruitus, acne.
Caulis bambusae in taenian：It is sweet, it is slightly cold.Return lung, stomach, the heart, gallbladder channel.With clearing heat and eliminating phlegm, relieving restlessness, effect of preventing or arresting vomiting.Coughed for phlegm heat
Cough, courage fire holds phlegm under the arm, palpitation with fear is not peaceful, vexed insomnia, middle wind phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pernicious vomiting, fetal irritability.
Dens draconis：It is cool in nature, it is sweet, puckery.With relieving convulsion effect of calming the nerves, for the disease such as palpitation and being susceptible to fright, vexed, insomnia and dreamful sleep.
Rabdosia rubescens：It is bitter, sweet, it is slightly cold.Return lung, stomach, Liver Channel.With clearing heat and detoxicating, the effect of promoting blood circulation and stopping pain.
Caulis Kadsurae：With blood circulation promoting and enriching, menstruction regulating and pain relieving, effect of channels sootheing and network vessel quickening.For irregular menstruation, dysmenorrhoea is numb
Paralysis, arthralgia pain due to rheumatism, deficient qi and blood.
Radix Glycyrrhizae：It is clearing heat and detoxicating with invigorating the spleen and benefiting qi, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription.
In the medicament composing prescription of the present invention, each drug component is through dialectical compatibility, and mutually assistant is helped in drug action, with heat-clearing benefit
Gas, nourshing kidney invigorating the spleen is the rules for the treatment of, acts on the organs such as spleen, liver, kidney, adjusts endocrine, repairs activation Stem Cells, makes internal
Carbohydrate, lipid and protein metabolism tend to be normal, fundamentally treat diabetes and a variety of complication as caused by diabetes.
The Chinese medicine composition of the present invention can be prepared using following methods：
(1) each traditional Chinese medicinal components are weighed by parts by weight in prescription, dragon-boat are spent, Chinese trumpet creeper, the taste medicine of dens draconis 3 dry, pulverize,
200-300 mesh sieves are crossed, medicinal powder is obtained, it is standby；
(2) by the Radix Astragali, the root of herbaceous peony, the wind-weed, Poria cocos, sealwort, the tuber of dwarf lilyturf, stringy stonecrop, wolf's milk, caulis bambusae in taenian, Rabdosia rubescens, Yunnan chicken blood
Rattan, the mixing of the taste medicine of Radix Glycyrrhizae 12, decocting are boiled 2 times, and the 8-10 times of water measured is added for the first time, is decocted 2-4 hours；Second of addition 6-8
The water of amount, is decocted 1-2 hours again, merges decoction liquor twice and filtering, and filtrate decompression concentration is measured relatively when being concentrated into 50 DEG C
Density is 1.2-1.3, obtains medicinal extract；
(3) the medicinal extract mixing that the medicinal powder and step (2) obtained step (1) is obtained, dries, produces.
The formulation medically approved, such as capsule can be made according to a conventional method for the Chinese medicine composition of the treatment diabetes of the present invention
Agent, tablet or granule.
Beneficial effects of the present invention：
(1) Chinese medicine composition for the treatment of diabetes of the invention is pure Chinese medicinal preparation, to the sugar triggered by endocrinopathy
Urine disease has significant curative effect, no obvious toxic-side effects；Overcome the medicines of traditional treatment diabetes largely using antidiabetic drug and
Insulin, cost is higher, the problem of using larger to human body side effect for a long time；
(2) instant effect, determined curative effect, medicine source is extensively, with low cost；
(3) efficient up to 94%, complication rate is small, treats both principal and secondary aspect of disease, and long-term effect is good.
Embodiment
Below by instantiation, the present invention will be further elaborated, it should explanation, the description below be only for
The present invention is explained, not its content is defined.
A kind of Chinese medicine composition for treating diabetes of embodiment 1
【Prescription】30 kilograms of the Radix Astragali, 25 kilograms of the root of herbaceous peony, 18 kilograms of the wind-weed, 14 kilograms of Poria cocos, 14 kilograms of sealwort, the tuber of dwarf lilyturf 8,000
Gram, 8 kilograms of stringy stonecrop, 8 kilograms of wolf's milk, dragon-boat spends 6 kilograms, 6 kilograms of Chinese trumpet creeper, 6 kilograms of caulis bambusae in taenian, 6 kilograms of dens draconis, Rabdosia rubescens
6 kilograms, 5 kilograms of Caulis Kadsurae, 9 kilograms of Radix Glycyrrhizae.
【Preparation method】(1) each traditional Chinese medicinal components are weighed by parts by weight in prescription, dragon-boat is spent, Chinese trumpet creeper, the taste medicine of dens draconis 3 are done
It is dry, crush, cross 300 mesh sieves, obtain medicinal powder, it is standby；
(2) by the Radix Astragali, the root of herbaceous peony, the wind-weed, Poria cocos, sealwort, the tuber of dwarf lilyturf, stringy stonecrop, wolf's milk, caulis bambusae in taenian, Rabdosia rubescens, Yunnan chicken blood
Rattan, the mixing of the taste medicine of Radix Glycyrrhizae 12, decocting are boiled 2 times, and the water of 9 times of amounts (ml/g) is added for the first time, is decocted 3 hours；Second of 7 times of addition
The water of (ml/g) is measured, is decocted 1.5 hours, merges decoction liquor twice and filtering, filtrate decompression concentration is measured when being concentrated into 50 DEG C
Relative density is 1.25, obtains medicinal extract；
(3) medicinal extract that the medicinal powder and step (2) obtained step (1) is obtained mixing, 70 DEG C of dryings 4 hours, is produced.
The capsule medically approved can be made according to a conventional method for the Chinese medicine composition of the present embodiment, and the specification of capsule is
0.3g/, usage and dosage is：2 times a day, 4 every time.
A kind of Chinese medicine composition of the diabetes of embodiment 2
【Prescription】25 kilograms of the Radix Astragali, 30 kilograms of the root of herbaceous peony, 15 kilograms of the wind-weed, 16 kilograms of Poria cocos, 12 kilograms of sealwort, the tuber of dwarf lilyturf 10,000
Gram, 5 kilograms of stringy stonecrop, 10 kilograms of wolf's milk, dragon-boat spends 5 kilograms, and 10 kilograms of Chinese trumpet creeper, 5 kilograms of caulis bambusae in taenian, 8 kilograms of dens draconis, the winter insults
4 kilograms of grass, 6 kilograms of Caulis Kadsurae, 8 kilograms of Radix Glycyrrhizae.
【Preparation method】(1) each traditional Chinese medicinal components are weighed by parts by weight in prescription, dragon-boat is spent, Chinese trumpet creeper, the taste medicine of dens draconis 3 are done
It is dry, crush, cross 300 mesh sieves, obtain medicinal powder, it is standby；
(2) by the Radix Astragali, the root of herbaceous peony, the wind-weed, Poria cocos, sealwort, the tuber of dwarf lilyturf, stringy stonecrop, wolf's milk, caulis bambusae in taenian, Rabdosia rubescens, Yunnan chicken blood
Rattan, the mixing of the taste medicine of Radix Glycyrrhizae 12, decocting are boiled 2 times, and the water of 8 times of amounts (ml/g) is added for the first time, is decocted 4 hours；Second of 8 times of addition
The water of (ml/g) is measured, is decocted 1 hour, merges decoction liquor twice and filtering, filtrate decompression concentration measures phase when being concentrated into 50 DEG C
It is 1.2 to density, obtains medicinal extract；
(3) medicinal extract that the medicinal powder and step (2) obtained step (1) is obtained mixing, 70 DEG C of dryings 4 hours, is produced.
The capsule medically approved can be made according to a conventional method for the Chinese medicine composition of the present embodiment, and the specification of capsule is
0.3g/, usage and dosage is：2 times a day, 4 every time.
A kind of Chinese medicine composition for treating diabetes of embodiment 3
【Prescription】35 kilograms of the Radix Astragali, 20 kilograms of the root of herbaceous peony, 20 kilograms of the wind-weed, 12 kilograms of Poria cocos, 16 kilograms of sealwort, the tuber of dwarf lilyturf 5,000
Gram, 10 kilograms of stringy stonecrop, 5 kilograms of wolf's milk, dragon-boat spends 10 kilograms, 5 kilograms of Chinese trumpet creeper, 10 kilograms of caulis bambusae in taenian, 4 kilograms of dens draconis, winter
Insult 8 kilograms of grass, 3 kilograms of Caulis Kadsurae, 10 kilograms of Radix Glycyrrhizae.
【Preparation method】(1) each traditional Chinese medicinal components are weighed by parts by weight in prescription, dragon-boat is spent, Chinese trumpet creeper, the taste medicine of dens draconis 3 are done
It is dry, crush, cross 300 mesh sieves, obtain medicinal powder, it is standby；
(2) by the Radix Astragali, the root of herbaceous peony, the wind-weed, Poria cocos, sealwort, the tuber of dwarf lilyturf, stringy stonecrop, wolf's milk, caulis bambusae in taenian, Rabdosia rubescens, Yunnan chicken blood
Rattan, the mixing of the taste medicine of Radix Glycyrrhizae 12, decocting are boiled 2 times, and the water of 10 times of amounts (ml/g) is added for the first time, is decocted 2 hours；Second of addition 6
The water of (ml/g) is measured again, is decocted 2 hours, merges decoction liquor twice and filtering, and filtrate decompression concentration is measured when being concentrated into 50 DEG C
Relative density is 1.3, obtains medicinal extract；
(3) medicinal extract that the medicinal powder and step (2) obtained step (1) is obtained mixing, 70 DEG C of dryings 4 hours, is produced.
The capsule medically approved can be made according to a conventional method for the Chinese medicine composition of the present embodiment, and the specification of capsule is
0.3g/, usage and dosage is：2 times a day, 4 every time.
Clinical data
First, physical data：
Case-data is selected from inpatient in May, -2013 in June, 2,009 240, is randomly divided into test group 120, wherein
Male 60, women 60；Control group 120, wherein male 60, women 60.Test group and control group age 35~
65 years old, the ratio between men and women and coincident with severity degree of condition had comparativity through Chi-square Test no significant difference (P ＞ 0.05).2nd, diagnose
Standard and criterion of therapeutical effect：
(1) diagnostic criteria：Case is selected according to WHO diabetes diagnostic criterions, type ii diabetes patient is, and meet
《The guideline of clinical investigations of new Chinese medicine treatment diabete (diabetes)》The middle dialectical standard of deficiency of both qi and yin disease.
(2) curative effect determinate standard
Formulated according to the Ministry of Public Health《The guideline of clinical investigations of new Chinese medicine treatment diabete (diabetes)》In treatment
Effect criterion is judged.
1. it is effective：Treatment declines more than 30% before blood glucose numerical value is relatively treated after two months；
2. it is effective：Treatment declines 29-10% before blood glucose numerical value is relatively treated after two months；
3. it is invalid：Treatment unchanged before blood glucose numerical value is relatively treated or decline less than 10% after two months.
3rd, clinical testing procedure：
(1) dosage regimen
Test group takes the capsule of the preparation of the embodiment of the present invention 1, and orally, 2 times a day, 4 every time；Control group, which is taken, to disappear
Thirsty Jiangtang capsule (Guangxi Tian medicine companies Co., Ltd, Chinese medicines quasi-word：Z20083229), orally, 3 times a day, 3 every time；
Test group and control group drug treatment are 60 days.
(2) observation index
Fasting blood-glucose and after the meal 2 hours blood glucose.
4th, clinical treatment outcome
Test group and the therapeutic effect of control group are shown in Table 1.As a result show, the clinical obvious effective rate of test group is 70.8%, always
Effective percentage is 94.0%, better than control group.Show the Chinese medicine composition determined curative effect of the present invention.Treat before and after test group and control
Group blood
The change of sugared numerical value is shown in Table 2.
The test group of table 1. and control group comparitive study
Table 2 treat front and rear blood glucose numerical value change (mmol/L,)
Note：Fasting blood-glucose numerical value compared with pre-treatment,*P ＜ 0.01；2h-plasma glucose numerical value compared with pre-treatment,*△P ＜
0.01。
Claims (2)
1. a kind of Chinese medicine composition for treating diabetes, it is characterised in that be made up of the bulk drug of following parts by weight：
30 parts of the Radix Astragali, 25 parts of the root of herbaceous peony, 18 parts of the wind-weed, 14 parts of Poria cocos, 14 parts of sealwort, 8 parts of the tuber of dwarf lilyturf, 8 parts of stringy stonecrop, 8 parts of wolf's milk,
Dragon-boat spends 6 parts, 6 parts of Chinese trumpet creeper, 6 parts of caulis bambusae in taenian, 6 parts of dens draconis, 6 parts of Rabdosia rubescens, 5 parts of Caulis Kadsurae, 9 parts of Radix Glycyrrhizae；
It is prepared from by following methods：
(1) each traditional Chinese medicinal components are weighed by parts by weight in prescription, dragon-boat is spent, Chinese trumpet creeper, the taste medicine of dens draconis 3 dry, pulverize, mistake
200-300 mesh sieves, obtain medicinal powder, standby；
(2) by the Radix Astragali, root of herbaceous peony, the wind-weed, Poria cocos, sealwort, the tuber of dwarf lilyturf, stringy stonecrop, wolf's milk, caulis bambusae in taenian, Rabdosia rubescens, Caulis Kadsurae, sweet
Careless 12 taste medicines mixing, decocting is boiled 2 times, and the 8-10 times of water measured is added for the first time, is decocted 2-4 hours；What second of 6-8 times of addition was measured
Water, is decocted 1-2 hours, merges decoction liquor twice and filtering, and filtrate decompression is concentrated, and measuring relative density when being concentrated into 50 DEG C is
1.2-1.3, obtains medicinal extract；
(3) the medicinal extract mixing that the medicinal powder and step (2) obtained step (1) is obtained, dries, produces.
2. the preparation method of the Chinese medicine composition of the treatment diabetes described in claim 1, it is characterised in that including following step
Suddenly：
(1) each traditional Chinese medicinal components are weighed by parts by weight in prescription, dragon-boat is spent, Chinese trumpet creeper, the taste medicine of dens draconis 3 dry, pulverize, mistake
200-300 mesh sieves, obtain medicinal powder, standby；
(2) by the Radix Astragali, root of herbaceous peony, the wind-weed, Poria cocos, sealwort, the tuber of dwarf lilyturf, stringy stonecrop, wolf's milk, caulis bambusae in taenian, Rabdosia rubescens, Caulis Kadsurae, sweet
Careless 12 taste medicines mixing, decocting is boiled 2 times, and the 8-10 times of water measured is added for the first time, is decocted 2-4 hours；What second of 6-8 times of addition was measured
Water, is decocted 1-2 hours, merges decoction liquor twice and filtering, and filtrate decompression is concentrated, and measuring relative density when being concentrated into 50 DEG C is
1.2-1.3, obtains medicinal extract；
(3) the medicinal extract mixing that the medicinal powder and step (2) obtained step (1) is obtained, dries, produces.
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| CN108498708A (en) * | 2018-04-18 | 2018-09-07 | 致宁医药（肇庆）股份有限公司 | A kind of Chinese medicine composition for treating diabetes |
| CN108324852A (en) * | 2018-04-19 | 2018-07-27 | 合肥市风达农业有限责任公司 | A kind of Chinese medicine composition for treating diabetes |
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