CN105148120A - Traditional Chinese medicine for effective prevention and cure of male hyperuricemia accompanied with gout - Google Patents

Abstract

The invention provides a traditional Chinese medicine for effective prevention and cure of male hyperuricemia accompanied with gout. The traditional Chinese medicine adopts Chinese herbs as raw materials, and can control the disease and relieve symptoms to enable a patient to gradually recover. According to the formula of the traditional Chinese medicine, kelp, lepidogrammitis rostrata (Bedd.) Ching, clerodendrum serratum (L.) moon, elsholtzia ciliata (Thunb.) Hyland., nothapodytes Pittosporoides (Oliv.) sleum., heartleaf houttuynia herb, fimbristylis dichotoma, root of coix lacryma-jobi, cucumber, willow leaf, radix zanthoxyli avicennae, vitis flexuosa Thunb., root of arachnoid cyanotis are taken as monarch and minister medicines for clearing heat to promote diuresis and purge turbidity, disintoxicating, treating stranguria and dispelling wind-evil; laminaria japonica aresch, sesame, alisma, mulberry, asparagus, chrysanthemum, lespedeza tomentosa (Thunb.) sieb., bauhinia root, sanchi flower, cherry leaf, phyllan lhus mat shilllirae and root of water spinach are taken as assistant and guide medicines for strengthening the spleen, reducing phlegm, expelling bruises, nourishing liver and kidney, controlling blood fat and regulating qi movement. A medicine formula preparation of the traditional Chinese medicine provided by the invention is a medicine which is nontoxic and free of side reaction, can inhibit formation of uric acid, promotes uric acid excretion, reduces non-essential diuretics, and can prevent and cure symptoms of male hyperuricemia accompanied with gout fundamentally. Compared with traditional Chinese medicines, the traditional Chinese medicine provided by the invention has the advantages of being easy to carry and take, and has a broad clinical application prospect.

Description

A kind of effective control male's metabolic arthritis disease with the Chinese medicine of gout

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of effective control male's metabolic arthritis disease with the Chinese medicine of gout.

Background technology

In recent years along with the change of people life style, the prevalence of hyperuricemia and gout, in ascendant trend gradually, is mainly in male, and has the tendency of rejuvenation, become a kind of commonly encountered diseases, the frequently-occurring disease of Urban population.Hyperuricemia and gout usually occur as diseases such as hypertension, coronary heart disease, diabetes with other metabolic diseases simultaneously, bring serious harm to human health.Have research display, hyperuricemia is atherosclerotic risk factor, and the occur together case fatality rate of Patients with Hyperuricemia of cardiovascular and cerebrovascular disease is in rising trend.Hyperuricemia is to define more than the value of the blood uric acid of 6mg/dL more than in 6.8 to 7.0mg/dL or women in male.Hyperuricemia and the metabolic disorder relevant to hyperuricemia such as gout have impact on the U.S. 3 to 5 million people.In the U.S., the probability that non-descendants American suffers from gout is the American twices of Caucasia descendants.And sub-and city, sub-Saharan Africa starts to become general China, Japan, Pohle Buddhist nun for gout and hyperuricemia, with the ratio that gout between 1990 and 2010 is approximately double.This increase of disease incidence it is believed that owing to longer life expection, changes in diet, alcohol consumption and the disease relevant to gout such as metabolism syndrome, renal insufficiency and hypertensive increase.Have found the many factors affecting gout ratio, comprise age, race and the season in 1 year.The male more than 30 years old with more than in the women of 50 years old, the popularity of gout is approximately two percentage ratios.The metabolic disorder relevant to hyperuricemia not only comprises gout and also comprises acute pain, deposition, urolithiasis, nephrolithiasis and gouty nephropathy owing to urate crystal in the deposition of urate crystal in the monarthric inflammatory arthritis of uric acid crystal, joint, excess of the kidney matter.Long-term nephrolithiasis and the known risk adding injury of kidney and renal failure of gouty nephropathy.Gout is the medical condition usually characterized by the recurrent exerbation of acute inflammatory arthritis.The metatarsophalangeal joints be arranged in bottom big toe the most affected (example about 50%) is.But gout also can exist as tophus, renal calculus or urate nephropathy.Gout it is believed that it is caused by the uric acid of elevated levels in blood, its crystallization and depositing in joint, tendon and surrounding tissue.Comprise by reducing the haemoconcentration that uratic dose is reduced uric acid to the treatment of hyperuricemia and gout at present, such as: 1) xanthine oxidase inhibitor, such as allopurinol and Febuxostat; 2) uricosuric agent, such as sulphinpyrazone, benzbromarone and probenecid; 3) urate oxidase, such as in order to do brother this, the uricase of Pu Ruikaixi, rasburicase and Pegylation; With 4) fenofibrate.In addition, the symptom of acute gout can be controlled by anti-inflammatory agent, such as: 1) Non-Steroidal Anti-Inflammatory medicine (NSAID), such as indomethacin and ibuprofen; 2) corticosteroid; With 3) Colchicine.Serum uric acid level is taken back sickness rate other metabolic disorders that also prevention is relevant with hyperuricemia that can reduce the acute gout of recurrence normal range.On clinical treatment, reducing the absorbing again of uric acid, increase the excretion of urine uric acid, is effective one of effective ways reducing serum Uric Acid Concentration in gout and hyperuricemia therapeutic process.In people's kidney, the heavy absorption process of uric acid depends on the special transport protein on film, i.e. uric acid transporter body 1 (UrateTransporter1, URAT1).URAT1 is a kind of uric acid-anion exchanger, is responsible for the heavily absorption of glomerular filtration 90% uric acid in proximal convoluted tubule.At present, in clinical conventional gout treatment medicine, the inhibition of benzbromarone to URAT1 is best, but due to its side effect more, numerous external pharmacy corporation is attached great importance to and is found new URAT1 inhibitor dropped into a large amount of manpower things.

Summary of the invention

The present invention, in order to solve the deficiencies in the prior art part, provides a kind of effective control male's metabolic arthritis disease and with the Chinese medicine of gout.

A kind of effective control male's metabolic arthritis disease of the present invention with the Chinese medicine of gout, by clinic tests and repeated verification configuration for many years, meet the theory of Chinese medicine.Formula take Chinese medicine as raw material, symptom management, and relief of symptoms makes patient's rehabilitation gradually.Formula is used for clearing away heat-damp and promoting diuresis with the medicine that Thallus Laminariae (Thallus Eckloniae), Herba Lepidogrammitis rostratae, Herba Clerodendri Serrati, Herba Origani, Cortex Nothapodytis Radicis, Herba Houttuyniae, Herba Fimbristylis dichotomae, Radix Coicis, Fructus Cucumidis sativi, Folium Salicis Babylonicae, Herba Kalimeridis, Radix Zanthoxyli Avicennae, Radix vitis flexuosae, Radix Cyanotis arachnoideae are the monarch and his subjects and lets out turbid, treating stranguria dispeling the wind of detoxifying; With Thallus Laminariae (Thallus Eckloniae), Semen Sesami, Rhizoma Alismatis, Fructus Mori, Germinatus Phragmitis, Flos Chrysanthemi, Radix Lespedezae Tomentosae, Radix Bauhihiae Championii, flower of Radix Notoginseng, Folium Pruni pseudocerasi, Herba Phyllanthi matsumuraes, the medicine of Radix ipomoeae aquaticae for assisting a ruler in governing a country, invigorating the spleen for dissipating phlegm blood stasis dispelling, nourishing the liver and kidney, controls blood fat, regulating QI machine.Pharmaceutical formulation preparation of the present invention, without toxicity, suppresses uric acid to be formed, promotes urate excretion medicine, reduces non-essential diuretic, fundamentally prevents and treats male's metabolic arthritis disease and with the symptom of gout.Compared with Chinese medicine, portable, the advantage easily taken, has wide clinical practice scene.

Effective control male's metabolic arthritis disease with the Chinese medicine of gout, be made up of following raw material:

Thallus Laminariae (Thallus Eckloniae) 10-20 part, Herba Lepidogrammitis rostratae 10-20 part, Herba Clerodendri Serrati 10-20 part, Herba Origani 10-20 part, Cortex Nothapodytis Radicis 10-20 part, Herba Houttuyniae 10-20 part, Herba Fimbristylis dichotomae 10-20 part, Radix Coicis 10-20 part, Fructus Cucumidis sativi 10-20 part, Folium Salicis Babylonicae 10-20 part, Herba Kalimeridis 10-20 part, Radix Zanthoxyli Avicennae 10-20 part, Radix vitis flexuosae 10-20 part, Radix Cyanotis arachnoideae 10-20 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Semen Sesami 10-20 part, Rhizoma Alismatis 10-20 part, Fructus Mori 10-20 part, Germinatus Phragmitis 10-20 part, Flos Chrysanthemi 10-20 part, Radix Lespedezae Tomentosae 10-20 part, Radix Bauhihiae Championii 10-20 part, flower of Radix Notoginseng 10-20 part, Folium Pruni pseudocerasi 10-20 part, Herba Phyllanthi matsumuraes 10-20 part, Radix ipomoeae aquaticae 10-20 part.

Preparation method:

(1), by formula proportion Fructus Cucumidis sativi, Germinatus Phragmitis, Fructus Mori adding distil water 100 parts are soaked 2 hours, wear into pasty state with fiberizer, be heated to boil 10 minutes, filter and be cooled to room temperature to make plant extraction liquid for subsequent use;

(2), will remain Chinese medicine pick clean according to formula proportion except Fructus Cucumidis sativi, Germinatus Phragmitis, Fructus Mori, screening is put into marmite and is added doubling dose pure water and decoct 30-40 minute, and extract supernatant and be cooled to room temperature, filtrate is for subsequent use; By the slag amount of doubling pure water again, decoct and pour filtrate into after boiling, until be boiled into paste, be cooled to room temperature post-drying → be crushed to 300 order fine powders for subsequent use;

(3), by fine powder for subsequent use add mix homogeneously in preparation method plant extraction liquid for subsequent use, then at 0-10 DEG C of temperature, use ultrasound wave homogenize 10-30 minute, subpackage is finished product.

Instructions of taking, each 40ML, point morning and evening 2 decoction being taken warmly, generally take medicine 8 days.

Effective control male's metabolic arthritis disease with the Chinese medicine of gout, be made up of following raw material:

Thallus Laminariae (Thallus Eckloniae) 12-16 part, Herba Lepidogrammitis rostratae 12-16 part, Herba Clerodendri Serrati 12-16 part, Herba Origani 12-16 part, Cortex Nothapodytis Radicis 12-16 part, Herba Houttuyniae 12-16 part, Herba Fimbristylis dichotomae 12-16 part, Radix Coicis 12-16 part, Fructus Cucumidis sativi 12-16 part, Folium Salicis Babylonicae 12-16 part, Herba Kalimeridis 12-16 part, Radix Zanthoxyli Avicennae 12-16 part, Radix vitis flexuosae 12-16 part, Radix Cyanotis arachnoideae 12-16 part, Thallus Laminariae (Thallus Eckloniae) 12-16 part, Semen Sesami 12-16 part, Rhizoma Alismatis 12-16 part, Fructus Mori 12-16 part, Germinatus Phragmitis 12-16 part, Flos Chrysanthemi 12-16 part, Radix Lespedezae Tomentosae 12-16 part, Radix Bauhihiae Championii 12-16 part, flower of Radix Notoginseng 12-16 part, Folium Pruni pseudocerasi 12-16 part, Herba Phyllanthi matsumuraes 12-16 part, Radix ipomoeae aquaticae 12-16 part.

Effective control male's metabolic arthritis disease with the Chinese medicine of gout, be made up of following raw material:

Thallus Laminariae (Thallus Eckloniae) 14 parts, Herba Lepidogrammitis rostratae 14 parts, Herba Clerodendri Serrati 14 parts, Herba Origani 14 parts, Cortex Nothapodytis Radicis 14 parts, Herba Houttuyniae 14 parts, Herba Fimbristylis dichotomae 14 parts, Radix Coicis 14 parts, Fructus Cucumidis sativi 14 parts, Folium Salicis Babylonicae 14 parts, Herba Kalimeridis 14 parts, Radix Zanthoxyli Avicennae 14 Fen, Radix vitis flexuosae 14 parts, Radix Cyanotis arachnoideae 14 parts, 14 parts, Thallus Laminariae (Thallus Eckloniae), Semen Sesami 14 parts, Rhizoma Alismatis 14 parts, 14 parts, Fructus Mori, Germinatus Phragmitis 14 parts, Flos Chrysanthemi 14 parts, Radix Lespedezae Tomentosae 14 parts, Radix Bauhihiae Championii 14 parts, flower of Radix Notoginseng 14 parts, Folium Pruni pseudocerasi 14 parts, Herba Phyllanthi matsumuraes 14 parts, Radix ipomoeae aquaticae 14 parts.

The present invention relates to raw material of Chinese medicine pharmacology and the property of medicine:

Thallus Laminariae (Thallus Eckloniae):

[meridian distribution of property and flavor] gas raw meat, salty in the mouth.Return liver, stomach, kidney channel.

[function cures mainly] has hard masses softening and resolving, expectorant, the function of diuretic.For phlegm retention edema.Have the merit of hard masses softening and resolving, detumescencing diuresis, relaxing the bowels with lubricant drugs expectorant, bronchitis, pulmonary tuberculosis swollen for goiter, lymphonodi cervicales, cough and senile cataract etc., also try out in Therapeutic cancer clinically.

Herba Lepidogrammitis rostratae:

[nature and flavor] micro-hardship; Sweet; Flat

[return through] lung; Small intestine meridian

[function cures mainly] clearing away heat and promoting diuresis; Cough-relieving; Relieving restlessness; Removing toxic substances and promoting subsidence of swelling.Main uroschesis; Drench the puckery pain of drop; Heat syndrome cough; Vexed; Skin infection swells and ache; Traumatic injury.

Herba Clerodendri Serrati:

[meridian distribution of property and flavor]: Xin Gan, temperature.Return spleen; Kidney channel

[function cures mainly] synthetism, pain relieving, preventing the attack (or recurrence) of malaria.Control fracture, traumatic injury, rheumatalgia, malaria.Clearing away heat-damp and promoting diuresis; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling.Main hygropyretic dysentery; Stranguria; Beriberoid pyretic arthralgia; Dysmenorrhea due to blood stasis; Traumatic injury; Laryngopharynx swelling and pain; Swollen ulcer drug; Urticaria; Malaria

1. " register planted by Guangxi medicine ": refute bone, parasite killing, stomach invigorating, clearing away heart-fire, strengthening bone and muscle.Treating malaria disease, dysentery, headache, ophthalmia, traumatic injury.

2. " Guizhou medical herbs ": invigorating spleen to remove dampness, tonify deficiency benefit is damaged.Control weak edema, impairment caused by overstrain.

3. " mountain of papers Chinese herbal medicine ": bone-setting pain stopping, heat-clearing and toxic substances removing.Control fracture, traumatic injury, rheumatalgia, innominate toxic swelling.

Herba Origani:

[nature and flavor]: " Guizhou folk medicine ": cool in nature, acrid in the mouth is nontoxic.

Effect: the warming middle-JIAO that induces sweat, (" Shaanxi Chinese herbal medicine ") induce sweat, and regulate the flow of vital energy, removing dampness.Diaphoresis, expelling summer-heat, diuresis.

[curing mainly]: control Common Cold, heating, vomiting, chest and diaphragm distension, diarrhoea, jaundice, infantile malnutrition.Summer catches a cold, fever without perspiration, heatstroke, and acute gastroenteritis is uncomfortable in chest, halitosis, dysuria.

1. " Guizhou folk medicine ": peeling skin is damp and hot, induces sweat, pain relieving, the wind that cures the wound generates heat, anti-nausea.

2. " register planted by Guangxi medicine ": subcutaneous ulcer of harnessing the Yellow River, infantile malnutrition, children's's diarrhea of heat type, edema.

3. " Shaanxi Chinese herbal medicine ": blood circulation promoting and blood stasis dispelling, pain relieving granulation promoting, sensible sharp diaphragm, regulating menstruation.

Control traumatic injury, fracture, chest and diaphragm distension, metrorrhagia, leucorrhea.

4. " Guizhou medical herbs ": induce sweat, regulate the flow of vital energy, dampness removing.

Cortex Nothapodytis Radicis:

[nature and flavor] are warm in nature, acrid in the mouth.[return through] lung; Liver Channel

[function cures mainly] expelling wind and removing dampness, cold expelling of regulating the flow of vital energy.Main anemofrigid-damp arthralgia; Edema; Hernia.

[usage and dosage] takes orally: decoct soup, 9-15g.External: appropriate, decocts water smoking and washes affected part.

[effect classification] dispel-wind drug; Dampness medicine

Herba Houttuyniae:

Nature and flavor

Not [nature and flavor] " not Lu ": acrid in the mouth, tepor.《 Lv Cliff rock book on Chinese herbal medicine ": cool in nature, nontoxic." the southern regions of the Yunnan Province book on Chinese herbal medicine ": cold in nature, bitter in the mouth is pungent.

[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.

Herba Fimbristylis dichotomae:

[nature and flavor] are lightly seasoned; Cold in nature

[return through] kidney; Urinary bladder channel

[function cures mainly] clearing away heat and promoting diuresis; Removing toxic substances.Main dysuria; Damp and hot edema; Gonorrhea; Infantile carbuncle

Radix Coicis:

[nature and flavor] are bitter sweet, cold.

1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": cold in nature, bitter but slightly sweet taste.

2. " detailed outline ": sweet, be slightly cold, nontoxic.

3. " Zhejiang traditional herbal medicine ": cool in nature, lightly seasoned, nontoxic.

[return through] " the southern regions of the Yunnan Province book on Chinese herbal medicine ": enter spleen, urinary bladder channel.

[function] heat clearing away, dampness removing, spleen invigorating, parasite killing.

To harness the Yellow River subcutaneous ulcer, edema, gonorrhea, hernia, amenorrhea, leukorrhagia, abdominal pain due to worm stagnation.

Fructus Cucumidis sativi:

Nature and flavor: sweet in the mouth; Cool in nature.

Gui Jing: return lung; Spleen; Stomach warp.

Function cures mainly: heat clearing away; Diuretic; Removing toxic substances.Main calentura is thirsty; Oliguria with reddish urine; Edema oliguria; Burn due to hot liquid or fire; Tinea versicolor; Non-skin ulcer.

Folium Salicis Babylonicae:

Heat-clearing and toxic substances removing, removing toxic substances rash, inducing diuresis for treating stranguria syndrome.Controlling acute diseases such as cholera and sunstroke rash sends out not smooth thoroughly, nebulousurine, furuncle furuncle and phyma, mastitis, and goiter, erysipelas, scalds, toothache.

Herba Kalimeridis:

[meridian distribution of property and flavor] acrid in the mouth, cold nature.Return liver, kidney, stomach, large intestine channel.

[effect] relieves internal heat anticancer, removing heat from blood scattered silt, clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.

Energy heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, and dampness removing, helps digestion, removing food stagnancy.For cat fever, cough, acute pharyngitis, tonsillitis, mumps, infectious hepatitis, taste-blindness rate, infantile malnutrition, enteritis, dysentery, spits blood, metrorrhagia, menoxenia; External is controlled furuncle and is swollen and ache, mastitis, traumatic hemorrhage; Dysentery or damp-heat diarrhea; Laryngopharynx swelling and pain, carbuncle skin infection; Heat in blood epistaxis, to have blood in stool; Jaundice due to damp-heat; Or edema, dysuria; Eating accumulation, distension and fullness in the abdomen.

Control traumatic injury, carbuncle, furuncle, hepatitis, nephritis, prostatitis, acute arthritis, stomachache, diarrhoea, dysentery, leucorrhea.

Radix Zanthoxyli Avicennae:

[nature and flavor] are pungent, temperature

[function cures mainly] dispels the wind, removing dampness, detumescence, dredging collateral.Control laryngopharynx swelling and pain, general edema with yellowish skin, malaria, rheumatic ostalgia, traumatic injury is dampened.

1. " book on Chinese herbal medicine asks former ": " reason phlegm-fire, wine expectorant, open laryngopharynx and swell and ache.Infusing drugs in wine method wind, reason traumatic injury."

2. " south of the Five Ridges gather medicinal herbs record ": " remove wind, harness the Yellow River swollen.Cure the wound again cold, yellow food card."

3. " SHENGCAO medicine handbook ": " control children's the ancient philosophers's expectorant (tripe is swollen, oliguria, anorexia, and blue veins network tripe person name the ancient philosophers expectorant is sick)."

4. " south of the Five Ridges herbal ": " detumescence, jaundice eliminating, reason distension, treating malaria is brought down a fever for removing dampness, wind dispelling."

Radix vitis flexuosae: (lei)

Radix vitis flexuosae is the root of vitaceae Pueraria lobota Bud, cures mainly the symptom such as body void, joint aches, traumatic injury after being ill.

Jiangxi " Chinese herbology ": " sweet, flat."

1. " not Lu ": " main slow muscle, order is not bitterly."

2. Jiangxi " Chinese herbology ": " nourishing qi and blood, reuniting the fractured tendons and bones, longue meat."

Radix Cyanotis arachnoideae:

[nature and flavor] pungent micro-hardship, temperature

[function cures mainly] promoting the flow of QI in the collateral by warming the meridian, removing damp and stopping pain.Treating rheumatic arthritis, numb limbs and tense tendons.

Thallus Laminariae (Thallus Eckloniae):

In Thallus Laminariae (Thallus Eckloniae), alginic acid sodium salt has the effect of pre-preventing leukemia and Itai-itai diseases; Also there is anastalsis to arterial hemorrhage, orally reduce the absorption of radioelement Strontium-90 in intestinal.Sodium alginate has hypotensive effect.Laminarin has the effect reducing blood fat.Also find that a kind of extract of Thallus Laminariae (Thallus Eckloniae) has antitumaous effect in recent years.Kelp mannitol is all effective to treatment acute renal decline, cerebral edema, second encephalitis, acute glaucoma.Deficiency and coldness of spleen and stomach person eat less;

[meridian distribution of property and flavor] nature and flavor: salty, cold.

1. " WU Pu Bencao ": " acid is salty, cold, nontoxic.”

2. " book on Chinese herbal medicine is new again ": " bitter in the mouth, cold in nature, nontoxic.”

Gui Jing: enter liver, stomach, kidney three warp

1. " key medicine divides agent ": " enter stomach warp.”

2. " book on Chinese herbal medicine is new again ": " enter spleen channel.”

[application]

For goiter, scrofula dysentery.These product alone, or with the compatibility such as Thallus Laminariae (Thallus Eckloniae), Thallus Laminariae, to strengthen the merit of expectorant and hard masses softening and resolving.

For hernia, testis cyst.Can with Sargassum, Fructus Foeniculi compatibility.

For edema, beriberi.Can with other diuretic compatibilities.

In addition, the modern times are again for hypertension, coronary heart disease, tumor etc.These product alone, or the medicine that compatibility is suitable.

[usage] decocts soup, boils, cold and dressed with sauce, soaking with sugar, or does ball, loose clothes

[function cures mainly] eliminating phlegm and softening indurated mass, the diuretic that expels the heat-evil, relieving cough and asthma, lipoid and reducing blood pressure of dispelling, eliminating stagnation are anticancer.For falling under goiter, scrofula, hernia, cough with asthma, edema, hypertension, coronary heart disease, obesity.

Semen Sesami:

Semen Sesami sweet in the mouth, property are flat, enter liver, kidney, lung, spleen channel.

Enrich blood improving eyesight, intestine moistening of dispeling the wind, the lactogenesis that promotes the production of body fluid, the liver benefiting hair care, keep fit effect of body, defying age.

Can be used for that treatment physical weakness, dizziness and tinnitus, hypertension, hyperlipidemia, cough, physical weakness, early whitening of hair, anemia are sallow, deficiency of body fluid, constipation due to dry stool, breast less, the disease such as hematuria.

[purposes] is deficient for Liver and kidney, asthenia of essence and blood, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, myasthenia of limbs; Puerperal blood deficiency, hypogalactia; Blood deficiency and depleted fluid, dryness of the intestine constipation etc.

Rhizoma Alismatis:

[meridian distribution of property and flavor] is sweet, cold; Return kidney, urinary bladder channel.

[function cures mainly] diuresis, clearing away damp-heat; For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.

Fructus Mori:

[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.

[function cures mainly] controls hepatic and renal YIN deficiency, sends and takes off, constipation, and order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, has potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and has auxiliary curative effect to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science is thought, Fructus Mori is sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.

Germinatus Phragmitis:

[pharmacology value] 1, contribute to stabilizing blood pressure blood fat reducing; 2, contribute to suppressing cardiovascular disease; 3, contribute to prevention and anticancer; 4, contribute to control senile constipation, diuresis to recover from fatigue; 5, contribute to suppressing and resisting viral bacterium; 6, health invigorating allaying tiredness is contributed to.

[nutritive value] 1, homovitamin, high-cellulose, high protein 2, low sugar, low fat 3, a great number of elements containing multiple needed by human and trace element

[health-care effect] 1, cancer-resisting effect, can suppress topoisomerase active, directly kill cancerous cell, destruction of cancer cells telomerase, makes cancerous cell can not multiple fission and wither it, activates antioncogene adjustment signal, transfer cell growth normalization.2, to the therapeutical effect of cardiovascular disease, Germinatus Phragmitis can suppress hypertension, prevents sclerosis of blood vessels, reduces blood fat and cholesterol.3, on the impact of human immune system, Germinatus Phragmitis can reduce circulating immune complex CIC content, can produce thymosin, promotes the generation of T cell, thus improves immunologic function, immunity moderation mechanism.4, the effect in defying age can reduce the lipid peroxide of human organ, the content of LOP, improves the activity of superoxide dismutase SOD thus slow down aging.

Flos Chrysanthemi:

There is dispelling wind, heat clearing away, improving eyesight ,effect of removing toxic substances.The disease such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Modern pharmacological research shows, Flos Chrysanthemi has treatment coronary heart disease, reduces blood pressure, prevents hyperlipidemia, antibacterial, antiviral, antiinflammatory, anti-ageing multiple pharmacologically active of waiting for a long time.

Radix Lespedezae Tomentosae:

[nature and flavor] are sweet; Micro-light; Property is put down

[return through] spleen channel

[function cures mainly] spleen invigorating tonify deficiency; Clearing away heat-damp and promoting diuresis; Promoting blood flow to regulate menstruation.Main asthenia; Blood deficiency is dizzy; Edema; Ascites; Dysentery; Amenorrhea; Dysmenorrhea

Radix Bauhihiae Championii:

Wind-damp dispelling, promoting the circulation of blood gas.Control traumatic injury, rheumatic ostalgia, heart peratodynia. ^[1]

1. " the SHENGCAO property of medicine is standby to be wanted ": " wind-damp dispelling, strengthening bone and muscle, reason traumatic injury wound.Again can circulation of qi promoting, control phlegm-fire."

2. " book on Chinese herbal medicine asks former ": " solution is smouldered, except infantile malnutrition furuncle, mixed hemorrhoids."

3. " Luchuan book on Chinese herbal medicine ": " promoting the circulation of QI to relieve pain control heart peratodynia, rheumatic ostalgia, lumbago."

4. " Guangxi Chinese herbal medicine ": " spleen reinforcing is regulated the flow of vital energy.Weak after curing the disease, infantile malnutrition."

Flower of Radix Notoginseng:

[nature and flavor] are cool in nature, sweet in the mouth, micro-hardship.

[function] is mainly used in that heat clearing away, removing toxic substances, removing heat from blood, blood pressure lowering, tune fat, immunomodulating, blood circulation and channel invigorating, health preserving are anti-ageing, the active ingredient of anti-inflammatory analgesic action.There is significant suppressing the hyperactive liver, eliminate the phlegm, relieving asthma, sleeping, effect such as coronary dilating, antiallergic, eliminating toxin and beautifying the skin of easing pain.

Folium Pruni pseudocerasi:

nature and flavor sweetness and bitterness temperature

gui Jing book on Chinese herbal medicine is new again enter liver spleen two warp

function cures mainly-effect of Folium Pruni pseudocerasi stomach warming spleen invigorating hemostasis removing toxic substances control cold syndrome of the stomach food stagnation diarrhoea spit blood sore

Herba Phyllanthi matsumuraes:

With all herbal medicine; Feeble QI is bitter in the mouth, puckery.1. revive doctor's " Chinese herbal medicine handbook ": heat clearing away, improving eyesight, stomach invigorating, dysentery relieving, eliminating dampness by diuresis, diuresis.

Control venom, infantile malnutrition.

And cure cold, eye conjunctivitis, summer-heat is suffered from diarrhoea, dysentery, nyctalopia, urinary tract infection, lithangiuria, oedema due to nephritis.

2. " Wenling county drug resource register ": liver heat removing and eyesight improving, treating dysentery and diarrhoea.

Along hepatitis jaundice, summer-heat is suffered from diarrhoea, red Hakuri, edema.

Radix ipomoeae aquaticae:

[return through] kidney; Lung; Spleen channel

[function cures mainly] invigorating spleen to remove dampness.Housewife female leucorrhea; Empty pouring

detailed description of the invention:

embodiment 1, formula:

Thallus Laminariae (Thallus Eckloniae) 10g, Herba Lepidogrammitis rostratae 10g, Herba Clerodendri Serrati 10g, Herba Origani 10g, Cortex Nothapodytis Radicis 10g, Herba Houttuyniae 10g, Herba Fimbristylis dichotomae 10g, Radix Coicis 10g, Fructus Cucumidis sativi 10g, Folium Salicis Babylonicae 10g, Herba Kalimeridis 10g, Radix Zanthoxyli Avicennae 10g, Radix vitis flexuosae 10g, Radix Cyanotis arachnoideae 10g, Thallus Laminariae (Thallus Eckloniae) 10g, Semen Sesami 10g, Rhizoma Alismatis 10g, Fructus Mori 10g, Germinatus Phragmitis 10g, Flos Chrysanthemi 10g, Radix Lespedezae Tomentosae 10g, Radix Bauhihiae Championii 10g, flower of Radix Notoginseng 10g, Folium Pruni pseudocerasi 10g, Herba Phyllanthi matsumuraes 10g, Radix ipomoeae aquaticae 10g.

Preparation method:

(1), by formula proportion Fructus Cucumidis sativi, Germinatus Phragmitis, Fructus Mori adding distil water 100 parts are soaked 2 hours, wear into pasty state with fiberizer, be heated to boil 10 minutes, filter and be cooled to room temperature to make plant extraction liquid for subsequent use;

(2), will remain Chinese medicine pick clean according to formula proportion except Fructus Cucumidis sativi, Germinatus Phragmitis, Fructus Mori, screening is put into marmite and is added doubling dose pure water and decoct 30-40 minute, and extract supernatant and be cooled to room temperature, filtrate is for subsequent use; By the slag amount of doubling pure water again, decoct and pour filtrate into after boiling, until be boiled into paste, be cooled to room temperature post-drying → be crushed to 300 order fine powders for subsequent use;

(3), by fine powder for subsequent use add mix homogeneously in preparation method plant extraction liquid for subsequent use, then at 0-10 DEG C of temperature, use ultrasound wave homogenize 10-30 minute, subpackage is finished product.

Instructions of taking, each 40ML, point morning and evening 2 decoction being taken warmly, generally take medicine 8 days.

embodiment 2, formula:

Thallus Laminariae (Thallus Eckloniae) 12g, Herba Lepidogrammitis rostratae 12g, Herba Clerodendri Serrati 12g, Herba Origani 12g, Cortex Nothapodytis Radicis 12g, Herba Houttuyniae 12g, Herba Fimbristylis dichotomae 12g, Radix Coicis 12g, Fructus Cucumidis sativi 12g, Folium Salicis Babylonicae 12g, Herba Kalimeridis 12g, Radix Zanthoxyli Avicennae 12g, Radix vitis flexuosae 12g, Radix Cyanotis arachnoideae 12g, Thallus Laminariae (Thallus Eckloniae) 12g, Semen Sesami 12g, Rhizoma Alismatis 12g, Fructus Mori 12g, Germinatus Phragmitis 12g, Flos Chrysanthemi 12g, Radix Lespedezae Tomentosae 12g, Radix Bauhihiae Championii 12g, flower of Radix Notoginseng 12g, Folium Pruni pseudocerasi 12g, Herba Phyllanthi matsumuraes 12g, Radix ipomoeae aquaticae 12g.

Preparation method is identical with embodiment 1 with usage and dosage.

embodiment 3, formula:

Thallus Laminariae (Thallus Eckloniae) 14g, Herba Lepidogrammitis rostratae 14g, Herba Clerodendri Serrati 14g, Herba Origani 14g, Cortex Nothapodytis Radicis 14g, Herba Houttuyniae 14g, Herba Fimbristylis dichotomae 14g, Radix Coicis 14g, Fructus Cucumidis sativi 14g, Folium Salicis Babylonicae 14g, Herba Kalimeridis 14g, Radix Zanthoxyli Avicennae 14g, Radix vitis flexuosae 14g, Radix Cyanotis arachnoideae 14g, Thallus Laminariae (Thallus Eckloniae) 14g, Semen Sesami 14g, Rhizoma Alismatis 14g, Fructus Mori 14g, Germinatus Phragmitis 14g, Flos Chrysanthemi 14g, Radix Lespedezae Tomentosae 14g, Radix Bauhihiae Championii 14g, flower of Radix Notoginseng 14g, Folium Pruni pseudocerasi 14g, Herba Phyllanthi matsumuraes 14g, Radix ipomoeae aquaticae 14g.

embodiment 4, formula:

Thallus Laminariae (Thallus Eckloniae) 16g, Herba Lepidogrammitis rostratae 16g, Herba Clerodendri Serrati 16g, Herba Origani 16g, Cortex Nothapodytis Radicis 16g, Herba Houttuyniae 16g, Herba Fimbristylis dichotomae 16g, Radix Coicis 16g, Fructus Cucumidis sativi 16g, Folium Salicis Babylonicae 16g, Herba Kalimeridis 16g, Radix Zanthoxyli Avicennae 16g, Radix vitis flexuosae 16g, Radix Cyanotis arachnoideae 16g, Thallus Laminariae (Thallus Eckloniae) 16g, Semen Sesami 16g, Rhizoma Alismatis 16g, Fructus Mori 16g, Germinatus Phragmitis 16g, Flos Chrysanthemi 16g, Radix Lespedezae Tomentosae 16g, Radix Bauhihiae Championii 16g, flower of Radix Notoginseng 16g, Folium Pruni pseudocerasi 16g, Herba Phyllanthi matsumuraes 16g, Radix ipomoeae aquaticae 16g.

Preparation method is identical with embodiment 1 with usage and dosage.

embodiment 5, formula:

Thallus Laminariae (Thallus Eckloniae) 20g, Herba Lepidogrammitis rostratae 20g, Herba Clerodendri Serrati 20g, Herba Origani 20g, Cortex Nothapodytis Radicis 20g, Herba Houttuyniae 20g, Herba Fimbristylis dichotomae 20g, Radix Coicis 20g, Fructus Cucumidis sativi 20g, Folium Salicis Babylonicae 20g, Herba Kalimeridis 20g, Radix Zanthoxyli Avicennae 20g, Radix vitis flexuosae 20g, Radix Cyanotis arachnoideae 20g, Thallus Laminariae (Thallus Eckloniae) 20g, Semen Sesami 20g, Rhizoma Alismatis 20g, Fructus Mori 20g, Germinatus Phragmitis 20g, Flos Chrysanthemi 20g, Radix Lespedezae Tomentosae 20g, Radix Bauhihiae Championii 20g, flower of Radix Notoginseng 20g, Folium Pruni pseudocerasi 20g, Herba Phyllanthi matsumuraes 20g, Radix ipomoeae aquaticae 20g.

Preparation method is identical with embodiment 1 with usage and dosage.

pharmacology pharmacodynamic is tested:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine preparation of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of Tablets and honey refining pill Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

Materials and methods

1.1 test compounds titles: treatment hyperuricemia compositions

1.2 preparations of falling urea composition solution treatment hyperuricemia compositions extractum distilled water is configured to respectively ultimate density 10,15, the solution of 20mg/mL, for administration.Detection system

1.3.1 material uric acid detection kit.Shandong kind mice.

Experimental procedure a, mice overnight fasting is affected on the uric acid of normal mouse after, by body weight random packet.Give clear water and high, normal, basic three the dosage groups for the treatment of hyperuricemia compositions of various dose, by the compound recipe of different ratio composition, administration volume is 20mL/kg.6h after administration, plucks eyeball and gets blood 0.5mL, and after room temperature leaves standstill 1h, 3000rpm is centrifugal prepares serum, gets serum kit measurement uric acid level, and whether the compound recipe adopting method of analysis of variance to compare different ratio has synergism.B, mice overnight fasting is affected on the uric acid of hyperuricemia model mice after, by body weight random packet.Give the treatment hyperuricemia compositions of various dose.3h after administration, gavage gives hypoxanthine 1000mg/kg, and simultaneously subcutaneous injection Oteracil Potassium 300mg/kg, cause hyperuricemia model, after 3h, eyeball gets blood 0.5mL, after room temperature leaves standstill 1h, 3000rpm is centrifugal prepares serum, gets serum kit measurement uric acid level, and whether the compound recipe adopting method of analysis of variance to compare different ratio has synergism.Interpretation of result

1.4.1 normal mouse gavage is affected on the uric acid of normal mouse and give treatment hyperuricemia compositions, between administration concentration 10 ~ 20mg/kg, produce obvious anti-uric acid effect, suppression ratio is up to 58.27%, and three groups of administration groups all have significant difference, the results are shown in Table 1.

Hyperuricemia compositions treated by table 1. affects the uric acid of normal mouse

The uric acid level of result treatment hyperuricemia compositions to normal mouse and hyperuricemia model mice all has significant reducing effect, and the effect suppressed has significant dose relationship, and has significant significant difference.

Conclusion result of the test shows, and treatment hyperuricemia compositions has obvious reducing effect to the uric acid level in animal body, has broad prospects preparing on uric acid resisting medicine.

typical clinical case inclusion criteria:

Inclusion criteria: there is typical clinical manifestation, meet diagnostic criteria.

MethodsThe cases enrolled 600 example.

1 clinical data

The all cases of 1.1 physical data are I Out-patient Department and inpatient, all confirm the patient of the treatment of metabolic arthritis disease through outpatient service.Treatment group 102 example; Matched group 40 example; 2 groups of ages, sex, occurring degree there are no significant difference, have comparability.

1.2 Therapeutic Method

Matched group adopts oral western medicine merely, serve on one week.

Treatment group Chinese traditional treatment, with oral Chinese medicine preparation of the present invention, serve on one week.

1.3 observational techniques 1. short term effect: after taking medicine, the cure rate of symptom, improvement rate.2. late result: reviewing patient is followed up a case by regular visits to, the record state of an illness.

2 observation of curative effect

2.1 efficacy assessment standard evaluation criterias are with reference to Ministry of Public Health clinical drug research guideline.

Curative effect judging standard:

1, invalid: front unchanged with treatment after blood uric acid treatment.

2, effective: blood uric acid comparatively before Xia Jiang≤20% to some extent, <20%.

3, effective: blood uric acid to recover normally or comparatively obviously Xia Jiang≤20%.

2.22 group results contrast

Treatment group cures 94 examples, and take a turn for the better 6 examples, invalid 2 examples, cure rate 92.15%, total effective rate 98.03%.Matched group cures 35 examples, and take a turn for the better 2 examples, invalid 3 examples, cure rate 87.5%, effective percentage 92.5%.

Through statistical procedures, 2 groups of there was no significant differences (P>0.05).

Example 1: 70 years old women with chronic gout and hyperuricemia history reinstates treatment by Chinese herbs of the present invention from January 2nd, 2013.After the treatment of 2 weeks, the serum uric acid level of patient is down to 7.5mg/dL.Acute attack is not observed at treatments period.Example 2: 66 years old male with chronic gout and hyperuricemia history reinstates treatment by Chinese herbs of the present invention from August 27th, 2014.After 1 week, his uric acid blood level is 9.5mg/dL when the 1st access, and after the treatment of 2 weeks, the serum uric acid level of patient is down to 6.4mg/dL and is kept below the upper limit of normal range.More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; the present invention also has various changes and modifications without departing from the spirit and scope of the present invention, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (3)

1. effective control male's metabolic arthritis disease with the Chinese medicine of gout, it is characterized in that: be made up of following raw material:

Thallus Laminariae (Thallus Eckloniae) 10-20 part, Herba Lepidogrammitis rostratae 10-20 part, Herba Clerodendri Serrati 10-20 part, Herba Origani 10-20 part, Cortex Nothapodytis Radicis 10-20 part, Herba Houttuyniae 10-20 part, Herba Fimbristylis dichotomae 10-20 part, Radix Coicis 10-20 part, Fructus Cucumidis sativi 10-20 part, Folium Salicis Babylonicae 10-20 part, Herba Kalimeridis 10-20 part, Radix Zanthoxyli Avicennae 10-20 part, Radix vitis flexuosae 10-20 part, Radix Cyanotis arachnoideae 10-20 part, Thallus Laminariae (Thallus Eckloniae) 10-20 part, Semen Sesami 10-20 part, Rhizoma Alismatis 10-20 part, Fructus Mori 10-20 part, Germinatus Phragmitis 10-20 part, Flos Chrysanthemi 10-20 part, Radix Lespedezae Tomentosae 10-20 part, Radix Bauhihiae Championii 10-20 part, flower of Radix Notoginseng 10-20 part, Folium Pruni pseudocerasi 10-20 part, Herba Phyllanthi matsumuraes 10-20 part, Radix ipomoeae aquaticae 10-20 part,

Preparation method:

(1), by formula proportion Fructus Cucumidis sativi, Germinatus Phragmitis, Fructus Mori adding distil water 100 parts are soaked 2 hours, wear into pasty state with fiberizer, be heated to boil 10 minutes, filter and be cooled to room temperature to make plant extraction liquid for subsequent use;

(2), will remain Chinese medicine pick clean according to formula proportion except Fructus Cucumidis sativi, Germinatus Phragmitis, Fructus Mori, screening is put into marmite and is added doubling dose pure water and decoct 30-40 minute, and extract supernatant and be cooled to room temperature, filtrate is for subsequent use; By the slag amount of doubling pure water again, decoct and pour filtrate into after boiling, until be boiled into paste, be cooled to room temperature post-drying → be crushed to 300 order fine powders for subsequent use;

(3), by fine powder for subsequent use add mix homogeneously in preparation method plant extraction liquid for subsequent use, then at 0-10 DEG C of temperature, use ultrasound wave homogenize 10-30 minute, subpackage is finished product.

2. a kind of effective control male's metabolic arthritis disease according to claim 1 with the Chinese medicine of gout, it is characterized in that: be made up of following raw material:

Thallus Laminariae (Thallus Eckloniae) 12-16 part, Herba Lepidogrammitis rostratae 12-16 part, Herba Clerodendri Serrati 12-16 part, Herba Origani 12-16 part, Cortex Nothapodytis Radicis 12-16 part, Herba Houttuyniae 12-16 part, Herba Fimbristylis dichotomae 12-16 part, Radix Coicis 12-16 part, Fructus Cucumidis sativi 12-16 part, Folium Salicis Babylonicae 12-16 part, Herba Kalimeridis 12-16 part, Radix Zanthoxyli Avicennae 12-16 part, Radix vitis flexuosae 12-16 part, Radix Cyanotis arachnoideae 12-16 part, Thallus Laminariae (Thallus Eckloniae) 12-16 part, Semen Sesami 12-16 part, Rhizoma Alismatis 12-16 part, Fructus Mori 12-16 part, Germinatus Phragmitis 12-16 part, Flos Chrysanthemi 12-16 part, Radix Lespedezae Tomentosae 12-16 part, Radix Bauhihiae Championii 12-16 part, flower of Radix Notoginseng 12-16 part, Folium Pruni pseudocerasi 12-16 part, Herba Phyllanthi matsumuraes 12-16 part, Radix ipomoeae aquaticae 12-16 part.

3. a kind of effective control male's metabolic arthritis disease according to claim 1 with the Chinese medicine of gout, it is characterized in that: be made up of following raw material:

Thallus Laminariae (Thallus Eckloniae) 14 parts, Herba Lepidogrammitis rostratae 14 parts, Herba Clerodendri Serrati 14 parts, Herba Origani 14 parts, Cortex Nothapodytis Radicis 14 parts, Herba Houttuyniae 14 parts, Herba Fimbristylis dichotomae 14 parts, Radix Coicis 14 parts, Fructus Cucumidis sativi 14 parts, Folium Salicis Babylonicae 14 parts, Herba Kalimeridis 14 parts, Radix Zanthoxyli Avicennae 14 Fen, Radix vitis flexuosae 14 parts, Radix Cyanotis arachnoideae 14 parts, 14 parts, Thallus Laminariae (Thallus Eckloniae), Semen Sesami 14 parts, Rhizoma Alismatis 14 parts, 14 parts, Fructus Mori, Germinatus Phragmitis 14 parts, Flos Chrysanthemi 14 parts, Radix Lespedezae Tomentosae 14 parts, Radix Bauhihiae Championii 14 parts, flower of Radix Notoginseng 14 parts, Folium Pruni pseudocerasi 14 parts, Herba Phyllanthi matsumuraes 14 parts, Radix ipomoeae aquaticae 14 parts.