CN105833055A - Traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia and preparing method and application thereof - Google Patents
Traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia and preparing method and application thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention relates to a traditional Chinese medicine composition for treating hypertension, hyperlipidemia and hyperglycemia and a preparing method and application thereof. The traditional Chinese medicine composition is prepared from the roots of red-rooted salvia, radix notoginseng, ginseng, flos rosae rugosae, rhizoma alismatis, ginkgo leaves, hawthorn, rhizoma chuanxiong, lotus leaves, safflowers, gastrodia elata and rhodiola rosea. The traditional Chinese medicine composition has the advantages of being lasting in effect and high in cure rate; the effective-ingredient extraction ratio of the preparing method is high, and capsules prepared with the method are convenient to take.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of treat the Chinese medicine composition of " three high ", its preparation side
Method and application.
Background technology
" three high " is the abbreviation of hypertension, high fat of blood, hyperglycaemia.Since entering 21 century, along with society
The fast development that meeting is economic, the living standard of the people improves constantly.Meanwhile, the change, bad of eating habit
The increasing of hobby, the factor such as increase the weight of of the quickening of work rhythm and social pressures, cause the morbidity of various disease
Rate increases substantially.Especially the " three high " crowd such as hypertension, high fat of blood, hyperglycaemia, already leads to people
Class sub-health state generally exists, and there are about 90,000,000 people altogether according to the Ministry of Public Health 2003 the statistics whole nation, suffer from
The crowd stating " three high " is easiest to cause the generation of the diseases such as cerebral thrombus, cerebral hemorrhage, coronary heart disease, and morbidity year
Rejuvenation increasingly in age, has caused global attention, and cardiovascular and cerebrovascular disease is classified as danger by the World Health Organization
First killer of evil human health.According to statistics, in annual death, the people of about 32% dies from heart and brain
Vascular diseases, not only the health to the mankind causes threat greatly, has also increased the weight of the burden of society.
At present, having quite a few Patients with Cardiovascular/Cerebrovascular Diseases is not single illness, but various disease conditions is simultaneously
Exist.As suffered from hypertension, high fat of blood or hyperglycemia simultaneously.And market supply is only to treat list mostly
The medicine of one illness, same for suffering from the patient of the various disease conditions such as hypertension, high fat of blood, hyperglycaemia simultaneously
Time take multi-medicament, bring inconvenience to patient.Some medicine there is also curative effect can not be lasting, drug withdrawal
After have a rebound, it is necessary to the most continual shortcoming taken.These problems affect the curative effect of medicine, give
Patient increases financial burden.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of Chinese medicine treating " three high "
Composition, its preparation method and application.Described Chinese medicine composition has the advantage that effect is lasting, cure rate is high,
Described preparation method has the advantage that effective component extraction rate is high, the capsule taking convenience prepared.
The technical solution adopted in the present invention is: a kind of Chinese medicine composition treating " three high ", it is characterised in that:
Make including following raw material: the red sage root, pseudo-ginseng, ginseng, rose, rhizoma alismatis, ginkgo leaf, hawthorn, rhizome of chuanxiong,
Lotus leaf, safflower, rhizoma Gastrodiae and rhodiola root.
For further enhancing effect of described Chinese medicine composition, preferred technical scheme is, the matter of described raw material
Amount part be: red sage root 100-200 part, pseudo-ginseng 50-100 part, ginseng 100-200 part, rose 50-150 part,
Rhizoma alismatis 150-250 part, ginkgo leaf 50-150 part, hawthorn 150-250 part, rhizome of chuanxiong 20-60 part, lotus leaf 50-150
Part, safflower 30-70 part, rhizoma Gastrodiae 50-150 part and rhodiola root 50-150 part.
Further, the mass parts of described raw material is: the red sage root 150 parts, pseudo-ginseng 80 parts, ginseng 150 parts,
Rose 100 parts, rhizoma alismatis 200 parts, ginkgo leaf 100 parts, hawthorn 200 parts, Ligusticum wallichii 40 parts, lotus leaf
100 parts, 50 parts of safflower, 100 parts of rhizoma Gastrodiae, rhodiola root 100 parts.
Present invention also offers the preparation method of a kind of described Chinese medicine composition, comprise the following steps:
A, by the described red sage root, pseudo-ginseng, ginseng, rose, rhizoma alismatis, ginkgo leaf, hawthorn, rhizome of chuanxiong, lotus
Leaf, safflower, rhizoma Gastrodiae and rhodiola root are immersed in the water immersion, then decoct 2-4 hour, obtain decoction liquor；
B, by decoction liquor filter, take filtrate；By dregs of a decoction soak by water 10-30 minute, after filtration, take filtrate,
The filtrate of twice filtration is mixed, obtains admixing medical solutions；
C, by admixing medical solutions heating concentrate prepare medicinal extract；
D, described medicinal extract is made softwood, pelletize, after whole grain sieves, obtain particle, particle is filled into
Capsule.
It should be noted that described Chinese medicine composition can be prepared as capsule, ability by method made above
Field technique personnel can the most described Chinese medicine composition technical, with reference to prior art, prepare
Other formulations such as tablet, granule, pill or paste, are not repeating at this.
For the active ingredient in described raw material fully being extracted, preferred technical scheme is, in step A,
Water is 2-4:1 with the mass ratio of whole raw materials；In step B, the mass ratio of water and the dregs of a decoction is 1-3:1.
Taking for convenience of follow-up handling process and patient, preferred technical scheme is: in step C, described
The density of medicinal extract is 1.1-1.2g/cm3；In step D, the grain density obtained after granulation and whole grain is 0.7-0.8
g/cm3；The loading of described particle is less than the half of capsule volume.
Present invention also offers the application in preparation treatment " three high " medicine of the described Chinese medicine composition, enter one
Step ground, the formulation of described medicine includes but not limited to: oral liquid, capsule, tablet, granule,
Pill or paste.
In order to preferably explain the present invention, below the raw material in the present invention and compatibility relationship are further elaborated.
The red sage root, Chinese medicine name.Dry root and rhizome for labiate red sage root Salvia miltiorrhiza Bge..
The red sage root has promoting blood circulation, inducing meastruation to relieve menalgia, and clear away heart-fire relieving restlessness, and cool blood disappears effect of carbuncle；For chest impediment and cardialgia,
Gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea swells and ache with sore through closing.
Pseudo-ginseng, Chinese medicine name.Doing for panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen
Dry and rhizome.Pseudo-ginseng has the hemostasis of the scattered stasis of blood, effect of detumescence ding-tong；For spitting blood, spit blood, bleeding from five sense organs or subcutaneous tissue,
Have blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain and tumbling and swelling.
Ginseng, Chinese medicine name, Classification system is Panax ginseng C.A.Mey, for strong tonic, is suitable for
In adjusting blood pressure, recovering cardiac function, neurasthenia and the disease such as in poor health, also eliminate the phlegm, stomach invigorating, profit
The effects such as urine, excitement.
Rose, for rosaceous plant rose and the flower of polyphyll rose.Before 5 to June full-bloom stage, pluck
Fully expanding but unopened bud, slow fire is dried or dries in the shade and get final product.Rose sweet and slightly bitter taste, slightly warm in nature,
Return liver, spleen, stomach warp；Fragrance row dissipates；There is effect of liver soothing and depression relief regulating menstruation by adjusting the flow of blood；Cure mainly chest diaphragm full vexed,
Gastral cavilty, the side of body rib, swollen breasts, irregular menstruation, leukorrhea with reddish discharge, dysentery, traumatic injury, wandering arthritis and
Carbuncle swells.
Rhizoma alismatis, Chinese medicine name, for the dry tuber of Notes On Alism At Aceae rhizoma alismatis Alisma orientalis (Sam.) Juzep..
Rhizoma alismatis has clearing damp and promoting diuresis, expels the heat-evil and changes effect of turbid lipopenicillinase；For difficult urination, oedema turgor, have loose bowels
Oliguria, phlegmatic vertigo, heat drenches puckery pain and hyperlipidemia.
Ginkgo leaf, for the dry leaf of Ginkgoaceae plant Ginkgo biloba Ginkgo bilobaL..Ginkgo leaf has invigorating blood circulation
The stasis of blood, removes obstruction in channels to relieve pain, and astringes the lung and relievings asthma and change effect of turbid lipopenicillinase；For obstruction of collaterals by blood stasis, chest impediment and cardialgia, apoplexy
Hemiplegia, the deficiency syndrome of the lung is coughed and is breathed heavily and hyperlipidemia.
Hawthorn, Chinese medicine name, for rosaceous plant large-fruited Chinese hawthorn Crataegus pin, natiida
Or the dry mature fruit of hawthorn Crataegus pin.nati fida Bge. Bge.var.majorN.E.Br..Hawthorn has
Food digesting stomach fortifying, promoting the circulation of qi is had to dissipate the stasis of blood and change effect of turbid lipopenicillinase；Stagnate for meat, gastral cavilty turgor, rushes down dysentery abdomen
Bitterly, hemostasis through closing, postpartum stasis blocking, trusted subordinate's shouting pain, chest impediment and cardialgia, hernia pain and hyperlipidemia.
Rhizome of chuanxiong, also known as Ligusticum wallichii, Classification system is Ligusticum chuanxiong hort.Rhizome of chuanxiong has pungent scattered temperature
Logical, promoting blood circulation and removing blood stasis, effect of promoting qi circulation and relieving pain, for " the gas medicine in blood ", have sensible qi and blood effect, therefore control gas
The chest side of body of stagnant blood stasis, all pains of belly.Rhizome of chuanxiong promoting blood circulation effect is extensive, the various illness of suitable stagnation of blood stasis；
Wind-expelling pain-stopping, effectiveness is favourable, can control a disease such as wind headache, arthralgia due to wind-dampness.
Lotus leaf, has effect of clearing away summer-heat and eliminating dampness, sending up the lucid yang and cooling blood and hemostasis；For hot summer weather polydipsia, summer-heat and damp
Having loose bowels, splenasthenic diarrhea, blood-head tells nosebleed, uterine bleeding of having blood in stool.
Safflower, Chinese medicine name, for the dry flower of feverfew safflower Carthamus tinctorius L..Safflower is used
In through closing, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, chest impediment and cardialgia, the stagnant stomachache of the stasis of blood, chest is coerced shouting pain, is fallen and flutter
Damage and sore swell and ache.
Rhizoma Gastrodiae, rare Chinese medicine, Classification system: Gastrodia elataBl..Rhizoma Gastrodiae is used as medicine with rhizome, in order to control
The diseases such as treatment is had a dizzy spell, extremity numbness, child convulsion.
Rhodiola root, Chinese medicine name, for dry root and the rhizome of Crassulaceae rhodiola, there is qi and activate blood circulation,
Promote blood circulation the merit relievingd asthma.Being mainly used in qi deficiency to blood stasis, chest impediment and cardialgia, hemiplegia, burnout is panted.
The invention have the benefit that
1, the invention provides a kind of Chinese medicine composition, wherein, consolidate with ginseng, be aided with pseudo-ginseng and the red sage root is dredged
Leading to the promoting blood circulation and removing blood stasis of blood vessel, safflower and rhizome of chuanxiong, rhizoma Gastrodiae and rhodiola root mainly act on the brain that " three high " causes
Portion's anoxic and headache；Add the hypoglycemic activity of the effect for reducing fat of hawthorn and lotus leaf, ginkgo leaf and rose,
The hypotensive activity of selfheal, rhizoma alismatis plays promotion blood sugar, the Excretion of blood fat wherein；By all medicines
Coordinate, play the effect of fast treating " three high ".
2, present invention also offers a kind of method that described Chinese medicine composition is prepared as capsule, by by Chinese medicine
Composition is prepared as capsule, facilitates patient to carry and uses, and alleviates the burden of taking medicine of patient.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate present disclosure.Should be appreciated that the enforcement of the present invention
Being not limited to the following examples, any pro forma accommodation and/or the change of being made the present invention all will fall
Enter scope.
In the present invention, if not refering in particular to, all of part, percentage are unit of weight, all of equipment and
Raw materials etc. are all commercially available or the industry is conventional.Method in following embodiment, as without saying especially
Bright, it is the conventional method of this area.
Embodiment 1
A kind of Chinese medicine composition treating " three high ", the raw material including following quality makes: red sage root 100g,
Pseudo-ginseng 100g, ginseng 100g, rose 150g, rhizoma alismatis 150g, ginkgo leaf 150g, hawthorn 150g,
Rhizome of chuanxiong 60g, lotus leaf 50g, safflower 70g, rhizoma Gastrodiae 50g and rhodiola root 150g.
The preparation method of described Chinese medicine composition, comprises the following steps:
A, by the described red sage root, pseudo-ginseng, ginseng, rose, rhizoma alismatis, ginkgo leaf, hawthorn, rhizome of chuanxiong, lotus
Leaf, safflower, rhizoma Gastrodiae and rhodiola root are immersed in the water immersion, and described water is 2:1 with the mass ratio of whole raw materials, then
Decoct 4 hours, obtain decoction liquor；
B, by decoction liquor filter, take filtrate；By dregs of a decoction soak by water 10 minutes, water and the mass ratio of the dregs of a decoction
For 3:1, after filtration, take filtrate, the filtrate of twice filtration is mixed, obtains admixing medical solutions；
C, by admixing medical solutions heating concentrate prepare medicinal extract, the density of described medicinal extract is 1.1g/cm3；
D, described medicinal extract is made softwood after, pelletize, after whole grain sieves, obtain particle, pelletize and whole grain
After the grain density that obtains be 0.8g/cm3；Particle is filled into capsule, and the loading of described particle is capsule
/ 4th of volume.
Embodiment 2
A kind of Chinese medicine composition treating " three high ", the raw material including following quality makes: red sage root 200g,
Pseudo-ginseng 50g, ginseng 200g, rose 50g, rhizoma alismatis 250g, ginkgo leaf 50g, hawthorn 250g, river
Vault 20g, lotus leaf 150g, safflower 30g, rhizoma Gastrodiae 150g and rhodiola root 50g.
The preparation method of described Chinese medicine composition, comprises the following steps:
A, by the described red sage root, pseudo-ginseng, ginseng, rose, rhizoma alismatis, ginkgo leaf, hawthorn, rhizome of chuanxiong, lotus
Leaf, safflower, rhizoma Gastrodiae and rhodiola root are immersed in the water immersion, and described water is 4:1 with the mass ratio of whole raw materials, then
Decoct 2 hours, obtain decoction liquor；
B, by decoction liquor filter, take filtrate；By dregs of a decoction soak by water 30 minutes, water and the mass ratio of the dregs of a decoction
For 1:1, after filtration, take filtrate, the filtrate of twice filtration is mixed, obtains admixing medical solutions；
C, by admixing medical solutions heating concentrate prepare medicinal extract, the density of described medicinal extract is 1.2g/cm3；
D, described medicinal extract is made softwood after, pelletize, after whole grain sieves, obtain particle, pelletize and whole grain
After the grain density that obtains be 0.7g/cm3；Particle is filled into capsule, and the loading of described particle is capsule
/ 2nd of volume.
Embodiment 3
A kind of Chinese medicine composition treating " three high ", the raw material including following quality makes: red sage root 150g,
Pseudo-ginseng 80g, ginseng 150g, rose 100g, rhizoma alismatis 200g, ginkgo leaf 100g, hawthorn 200g,
Rhizome of chuanxiong 40g, lotus leaf 100g, safflower 50g, rhizoma Gastrodiae 100g and rhodiola root 100g.
The preparation method of described Chinese medicine composition, comprises the following steps:
A, by the described red sage root, pseudo-ginseng, ginseng, rose, rhizoma alismatis, ginkgo leaf, hawthorn, rhizome of chuanxiong, lotus
Leaf, safflower, rhizoma Gastrodiae and rhodiola root are immersed in the water immersion, and described water is 3:1 with the mass ratio of whole raw materials, then
Decoct 3 hours, obtain decoction liquor；
B, by decoction liquor filter, take filtrate；By dregs of a decoction soak by water 20 minutes, water and the mass ratio of the dregs of a decoction
For 2:1, after filtration, take filtrate, the filtrate of twice filtration is mixed, obtains admixing medical solutions；
C, by admixing medical solutions heating concentrate prepare medicinal extract, the density of described medicinal extract is 1.15g/cm3；
D, described medicinal extract is made softwood after, pelletize, after whole grain sieves, obtain particle, pelletize and whole grain
After the grain density that obtains be 0.75g/cm3；Particle is filled into capsule, and the loading of described particle is capsule
/ 3rd of volume.
Experimental example
The therapeutic test below done for heretofore described Chinese medicine composition: in this experimental example, with embodiment
Proportioning and preparation method in 3 are as the criterion.
(1), testing crew physical data
Select the 400 example hypertension through making a definite diagnosis, high fat of blood, hyperglycemic patients, the most individually suffer from hypertension
Patient 49 example；Individually suffers from patient 54 example of high fat of blood；Individually suffers from patient 51 example of hyperglycaemia；With
Time suffer from patient 46 example of hypertension and high fat of blood；Suffers from patient 53 example of hypertension and hyperglycaemia simultaneously；
Suffer from patient 47 example of high fat of blood and hyperglycaemia simultaneously, suffer from the trouble of hypertension, high fat of blood and hyperglycaemia simultaneously
Person 100 example.In 400 example patients, M-F is 1:1, age 26～80 years old and in normal distribution, averagely
53 years old age.
(2), testing crew diagnosis basis
The diagnosis of diabetes meet 1997 ADA (ADA) standard (money is honourably obtained. glycosuria
Sick clinical guidelines. Beijing: publishing house of Beijing Medical University .2000.214-218).Hyperlipidemia diagnosis reference " in
Doctor's Clinical Researches of New Drugs guideline " (Ministry of Health of the People's Republic of China. traditional Chinese medical science Clinical Researches of New Drugs instructs former
Then. second volume of .1995.171-174.) in relevant standard: in the case of normal diet, such as 2 survey blood in 2 weeks
Clear T-CHOL (TC) >=6.0mmol/L, or cruel (the TG) >=1.54mmol/L of serum glycerine three, or highly dense
Degree lipoproteins-C (HDL-C): the male sex≤1.04mmol/L, women≤1.77mmol/L person.High
The diagnosis of blood pressure meets " Hypertension Guideline " (WHO.1999 world health group that WH01999 announces
Knit/antihypertensive alliance of state is about Treatment Guidelines for Hypertension. hypertension magazine .1999. (7): 97-100) in high blood
Compression set justice and classification, staging scale.
(3), test method
Three times on the one, each taking and being converted into raw medicinal material amount is 0.5-1g, takes continuously three months, if fullying recover from an illness
More then withdrawal.
(4), curative effect determinate standard
Reference " traditional Chinese medical science Clinical Researches of New Drugs guideline " (Ministry of Health of the People's Republic of China. traditional Chinese medical science new drug faces
Bed research guideline. second volume of .1995.171-174.) in relevant standard formulation.
Effective: clinical symptoms disappear substantially；Blood fat, fasting blood-glucose and postprandial blood sugar etc. improve more than 30%
Or reach normal value；Blood pressure reaches following any one person 1. diastolic pressure and declines more than l0mmHg, and reaches normal value
Scope, though 2. diastolic pressure does not reaches normally, but decline 20mmHg or more than.
Effective: clinical symptoms are improved；Blood fat, fasting blood-glucose and postprandial blood sugar etc. improve more than 10%, but
Do not reach effective standard；Blood pressure reaches following any one person 1. diastolic pressure and declines not as good as l0mmHg, but just reaches
Constant value scope；2. decline 10-19mmHg before diastolic pressure is relatively treated, but not up to range of normal value；3. shrink
More than 30mmhg is declined before pressure relatively treatment.
Invalid: after treatment, clinical symptoms are without improving, blood fat, fasting blood-glucose and postprandial blood sugar etc. improve 10% with
Under, blood pressure detecting declines below 30mmHg or without improving before shrinking pressure relatively treatment.
Effective and effectively count total effective rate.
(5), result of the test and conclusion
Experimental result is as shown in table 1
Table 1: experimental result table
Conclusion: the Chinese medicine composition in the present invention, is coordinated by all medicines, and total effective rate has reached 89-94.4%,
And nothing recurs after most patients cure, illustrate that described Chinese medicine composition is effective persistently, cure rate is high
Advantage.
(6), the concrete case of part:
1, Zhang, man, 56 years old；Hypertension, high fat of blood, hyperglycaemia cause cardiovascular and cerebrovascular blocking, cause
Half of health is numb and cold, and main suit has a headache dizziness 3 years, accompanies dry, body sleepiness power, blood pressure
190/120mmHg, lipid examination: cholesterol 6.3mm/L, triglyceride 2.18mm/L, beta lipoprotein
10.16g/L, fasting blood-glucose 7.9mm/L, after the meal 2 hours blood glucose 12.5mm/L, doctor trained in Western medicine be diagnosed as hypertension,
High fat of blood, hyperglycaemia.Take multiple western drug poor effect, after taking the Chinese medicine composition in the present invention,
Within one month, symptom is clearly better, rehabilitation after continuing to take 3 months, follows up a case by regular visits to not recur for many years.
2, Lee, man, 76 years old, suffer from hypertension, hyperglycaemia, wherein blood pressure 180-200/100-110mmHg,
Fasting blood-glucose 8.1mm/L, after the meal 2 hours blood glucose 12.8mm/L, take the Chinese medicine composition 3 in the present invention
Rehabilitation after individual month, does not recurs so far.
3, Wang, female, 51 years old, hyperglycaemia, fasting blood-glucose 8.4mm/L, after the meal 2 hours blood glucose 12.6mm/L,
Give an oral account thirsty, cold perspiration of sleeping irritated, evening, insomnia, take Chinese medicine composition in the present invention 2 months
Rear rehabilitation, does not recurs so far.
4, week certain, female, 47 years old, people from Hui nationality grade teacher, suffer from hypertension, high fat of blood, hyperglycaemia,
The large hospital such as Beijing, Shanghai is repeatedly gone to treat, blood pressure still 180-200/100-110mmHg, leg pain numbness,
Take the present invention after 1 month blood pressure steady, blood sugar declines, and both legs pain disappears, in taking in the present invention
Drug composition rehabilitation after 3 months, does not recurs so far.
5, Song, man, 65 years old, suffer from cerebral infarction, the cardiovascular and cerebrovascular diseases such as informal dress thrombus-eliminating pills, cerebral ischemic are special
Medication, left side hemiplegia, hypertension, palpitaition, cardiac arrhythmia, can't take care of oneself.Through taking this
Chinese medicine composition in bright is after 3 months, blood pressure stabilization, can take part in the work, and health is normal so far.
It should be noted last that, above example only in order to technical scheme to be described and unrestricted,
Although the present invention being described in detail with reference to preferred embodiment, be it should be understood that and be the foregoing is only
The detailed description of the invention of the present invention, the protection domain being not intended to limit the present invention, all the present invention's
Within spirit and principle, any modification, equivalent substitution and improvement etc. done, should be included in the present invention's
Within protection domain.
Claims (10)
1. the Chinese medicine composition treating " three high ", it is characterised in that include that following raw material is made:
The red sage root, pseudo-ginseng, ginseng, rose, rhizoma alismatis, ginkgo leaf, hawthorn, rhizome of chuanxiong, lotus leaf, safflower, rhizoma Gastrodiae
And rhodiola root.
Chinese medicine composition the most according to claim 1, it is characterised in that the mass parts of described raw material
For: red sage root 100-200 part, pseudo-ginseng 50-100 part, ginseng 100-200 part, rose 50-150 part, pool
Rush down 150-250 part, ginkgo leaf 50-150 part, hawthorn 150-250 part, rhizome of chuanxiong 20-60 part, lotus leaf 50-150
Part, safflower 30-70 part, rhizoma Gastrodiae 50-150 part and rhodiola root 50-150 part.
Chinese medicine composition the most according to claim 2, it is characterised in that the mass parts of described raw material
For: the red sage root 150 parts, pseudo-ginseng 80 parts, ginseng 150 parts, rose 100 parts, rhizoma alismatis 200 parts, ginkgo
100 parts of leaf, hawthorn 200 parts, Ligusticum wallichii 40 parts, 100 parts of lotus leaf, 50 parts of safflower, 100 parts of rhizoma Gastrodiae,
Rhodiola root 100 parts.
4. the preparation method of the arbitrary described Chinese medicine composition of claim 1-3, it is characterised in that include
Following steps:
A, by the described red sage root, pseudo-ginseng, ginseng, rose, rhizoma alismatis, ginkgo leaf, hawthorn, rhizome of chuanxiong, lotus
Leaf, safflower, rhizoma Gastrodiae and rhodiola root are immersed in the water immersion, then decoct 2-4 hour, obtain decoction liquor；
B, by decoction liquor filter, take filtrate；By dregs of a decoction soak by water 10-30 minute, after filtration, take filtrate,
The filtrate of twice filtration is mixed, obtains admixing medical solutions；
C, by admixing medical solutions heating concentrate prepare medicinal extract；
D, described medicinal extract is made softwood, pelletize, after whole grain sieves, obtain particle, particle is filled into
Capsule.
Preparation method the most according to claim 4, it is characterised in that in step A, water and whole raw materials
Mass ratio be 2-4:1.
The matter of preparation method the most according to claim 4, it is characterised in that in step B, water and the dregs of a decoction
Amount ratio is 1-3:1.
Preparation method the most according to claim 4, it is characterised in that in step C, described medicinal extract close
Degree is 1.1-1.2g/cm3。
Preparation method the most according to claim 4, it is characterised in that in step D, pelletizes and after whole grain
The grain density obtained is 0.7-0.8g/cm3；The loading of described particle is less than the half of capsule volume.
9. claim 1-3 arbitrary described Chinese medicine composition application in preparation treatment " three high " medicine.
Application the most according to claim 9, it is characterised in that the formulation of described medicine include but not
It is limited to: oral liquid, capsule, tablet, granule, pill or paste.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107485687A (en) * | 2017-07-07 | 2017-12-19 | 杨雪林 | A kind of health products promoting blood circulation and removing blood stasis |
| CN111494556A (en) * | 2020-05-25 | 2020-08-07 | 海南武国中医生物技术开发有限公司 | Traditional Chinese medicine composition for preventing and treating three highs and fatty liver and preparation and application thereof |
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| CN101874875A (en) * | 2010-05-26 | 2010-11-03 | 唐桂德 | Chinese medicinal tea for treating hypertension, hyperlipoidemia and high blood viscosity and preparation method thereof |
| CN103638302A (en) * | 2013-12-03 | 2014-03-19 | 苏甲臣 | Medicine for treating hyperlipemia |
| CN104663960A (en) * | 2013-11-27 | 2015-06-03 | 黄崇荣 | Traditional Chinese medicine health tea for preventing and treating three highs |
| CN105079577A (en) * | 2015-09-24 | 2015-11-25 | 谢志明 | Traditional Chinese medicine composition for treating hypertension and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455791A (en) * | 2008-11-27 | 2009-06-17 | 朱新华 | Pure traditional Chinese medicine preparation for treating hyperlipemia |
| CN101874875A (en) * | 2010-05-26 | 2010-11-03 | 唐桂德 | Chinese medicinal tea for treating hypertension, hyperlipoidemia and high blood viscosity and preparation method thereof |
| CN104663960A (en) * | 2013-11-27 | 2015-06-03 | 黄崇荣 | Traditional Chinese medicine health tea for preventing and treating three highs |
| CN103638302A (en) * | 2013-12-03 | 2014-03-19 | 苏甲臣 | Medicine for treating hyperlipemia |
| CN105079577A (en) * | 2015-09-24 | 2015-11-25 | 谢志明 | Traditional Chinese medicine composition for treating hypertension and preparing method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107485687A (en) * | 2017-07-07 | 2017-12-19 | 杨雪林 | A kind of health products promoting blood circulation and removing blood stasis |
| CN111494556A (en) * | 2020-05-25 | 2020-08-07 | 海南武国中医生物技术开发有限公司 | Traditional Chinese medicine composition for preventing and treating three highs and fatty liver and preparation and application thereof |
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Application publication date: 20160810 |