CN105147956A - Traditional Chinese medicine for treating acute peptic ulcer bleeding and preparation method of traditional Chinese medicine - Google Patents
Traditional Chinese medicine for treating acute peptic ulcer bleeding and preparation method of traditional Chinese medicine Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating acute peptic ulcer bleeding and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw medicinal materials: aster fastigiatus, crossostephium chinense, luffa fruit pedicel, aloe root, ludwigia prostrate, root of lindley butterflybush, alisma canaliculatum, scabrous doellingeria rhizome and root, ficus tikoua, leaves of agave americana, fortune firethorn fruit, melastoma candidum, aralia yunnanensis, pakchoi seedling, malus formosana, pueraria omeiensis and triglochin martimum. The traditional Chinese medicine has the benefits that the traditional Chinese medicine can treat acute peptic ulcer bleeding and has the advantages of being definite in curative effect, quick to take effect and free of toxic and side effect.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly relate to and a kind ofly treat the hemorrhage Chinese medicine of acute peptic ulcer and preparation method.
Background technology
Acute peptic ulcer is hemorrhage mainly refers to that to occur in harmonization of the stomach duodenal exedens hemorrhage, be acute hemorrhage of upper gastrointestinal tract most commonly encountered diseases because of, account for 40 ~ 50%.Although primary disease great majority are self limiting, about 80% hemorrhagely can to stop voluntarily, still have potential life danger, the generation of peripheral circulatory failure and hemorrhagic anemia can cause death, and mortality rate is about 10%.In addition, about have the hemorrhage case of 5% to be continued hemorrhage, 20%-25% patient can occur in 48 hours hemorrhage in onset again, these continued hemorrhages or patient hemorrhage again, and old people or to have patient's case fatality rate of serious complication then higher.
Current western medical treatment digestive ulcerative bleeding can be divided into general treatment, Drug therapy, Endoscopic Treatment, intervention and operative treatment, and the main state of an illness row individuation rescus by stages according to each patient, wherein extensive with the use of antisecretory clinically.But the report in recent years about antisecretory side effect is increasing, having research to point out, Aomei draws causes leukopenia, anaphylactic shock, arrhythmia, the serious adverse reactions such as psychological problem.Although occur that the case load of this side effect is relatively rare, also to a certain extent query is proposed to this Drug safety of use.In addition, the advantage of western medical treatment primary disease is mainly reflected in hemostasis and promotes ulcer healing aspect, for clinical more relevant common symptons, as not obvious in curative effects such as flatulence, poor appetite, dry mouth with bitter taste, or without effect, even increase the weight of the symptom of class or produce related reactions, reducing the quality of life of patient to a certain extent.Therefore, have very much the better Chinese medicine of curative effect must be adopted to give treatment to.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of determined curative effect and the hemorrhage Chinese medicine of the little treatment acute peptic ulcer of toxic and side effects and preparation method.
Ask to solve above-mentioned technology, the invention provides and a kind ofly treat the hemorrhage Chinese medicine of acute peptic ulcer, comprise following raw medicinal material: Herba Turczaninowiae Fastigiatae, Chinese mugwort, Pedicellus Luffae, Radix of Aloe, Herba Ludwigiae Prostratae, Radix Buddlejae Butterflybush, Herba Alismatis Canaliculati, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Radix Fici tikouae, Folium Agaves variegatae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Herba Melastomatis Candii, careless Radix Angelicae Pubescentis, Plantula Brassicae chinensis, Fructus Mali Asiaticae, Radix Puerariae Omeiensis and Herba Triglochinis in thousand.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Turczaninowiae Fastigiatae 20 ~ 30 parts, Chinese mugwort in thousand 10 ~ 20 parts, Pedicellus Luffae 15 ~ 25 parts, Radix of Aloe 20 ~ 30 parts, Herba Ludwigiae Prostratae 10 ~ 20 parts, Radix Buddlejae Butterflybush 10 ~ 20 parts, Herba Alismatis Canaliculati 5 ~ 15 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 ~ 30 parts, Radix Fici tikouae 10 ~ 20 parts, Folium Agaves variegatae 20 ~ 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 20 ~ 30 parts, Herba Melastomatis Candii 30 ~ 40 parts, careless Radix Angelicae Pubescentis 15 ~ 25 parts, Plantula Brassicae chinensis 10 ~ 20 parts, Fructus Mali Asiaticae 10 ~ 20 parts, Radix Puerariae Omeiensis 15 ~ 25 parts and Herba Triglochinis 10 ~ 20 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can also be preferably as follows: Herba Turczaninowiae Fastigiatae 20 ~ 25 parts, Chinese mugwort in thousand 15 ~ 20 parts, Pedicellus Luffae 18 ~ 23 parts, Radix of Aloe 22 ~ 27 parts, Herba Ludwigiae Prostratae 13 ~ 18 parts, Radix Buddlejae Butterflybush 10 ~ 15 parts, Herba Alismatis Canaliculati 8 ~ 13 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 ~ 25 parts, Radix Fici tikouae 13 ~ 18 parts, Folium Agaves variegatae 25 ~ 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 22 ~ 27 parts, Herba Melastomatis Candii 30 ~ 35 parts, careless Radix Angelicae Pubescentis 17 ~ 22 parts, Plantula Brassicae chinensis 15 ~ 20 parts, Fructus Mali Asiaticae 12 ~ 17 parts, Radix Puerariae Omeiensis 18 ~ 23 parts and Herba Triglochinis 13 ~ 18 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine also can be preferably as follows: Herba Turczaninowiae Fastigiatae 22 parts, Chinese mugwort in thousand 18 parts, Pedicellus Luffae 20 parts, Radix of Aloe 26 parts, Herba Ludwigiae Prostratae 14 parts, Radix Buddlejae Butterflybush 15 parts, Herba Alismatis Canaliculati 12 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 parts, Radix Fici tikouae 16 parts, Folium Agaves variegatae 26 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 26 parts, Herba Melastomatis Candii 32 parts, careless Radix Angelicae Pubescentis 20 parts, Plantula Brassicae chinensis 16 parts, Fructus Mali Asiaticae 17 parts, Radix Puerariae Omeiensis 20 parts and Herba Triglochinis 17 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows again: Herba Turczaninowiae Fastigiatae 24 parts, Chinese mugwort in thousand 15 parts, Pedicellus Luffae 22 parts, Radix of Aloe 24 parts, Herba Ludwigiae Prostratae 18 parts, Radix Buddlejae Butterflybush 10 parts, Herba Alismatis Canaliculati 9 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 24 parts, Radix Fici tikouae 14 parts, Folium Agaves variegatae 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 24 parts, Herba Melastomatis Candii 34 parts, careless Radix Angelicae Pubescentis 18 parts, Plantula Brassicae chinensis 20 parts, Fructus Mali Asiaticae 12 parts, Radix Puerariae Omeiensis 23 parts and Herba Triglochinis 14 parts.
When the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Beneficial effect of the present invention: Chinese medicine of the present invention, treatment acute peptic ulcer is hemorrhage, the advantage having determined curative effect, instant effect and have no side effect.
Detailed description of the invention
The invention provides and a kind ofly treat the hemorrhage Chinese medicine of acute peptic ulcer, comprise following raw medicinal material: Herba Turczaninowiae Fastigiatae, Chinese mugwort in thousand, Pedicellus Luffae, Radix of Aloe, Herba Ludwigiae Prostratae, Radix Buddlejae Butterflybush, Herba Alismatis Canaliculati, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Radix Fici tikouae, Folium Agaves variegatae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Herba Melastomatis Candii, careless Radix Angelicae Pubescentis, Plantula Brassicae chinensis, Fructus Mali Asiaticae, Radix Puerariae Omeiensis and Herba Triglochinis.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba Turczaninowiae Fastigiatae: [another name] as if white aster, women weaver aster, female, female's intestinal, Herba Turczaninowiae Fastigiatae, cogongrass.[source] medical material Ji Yuan: be root or the herb of feverfew Herba Turczaninowiae Fastigiatae.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] warming the lung for resolving phlegm; Invigorating spleen to remove dampness.Main cough and asthma; Dysentery; Oliguria is puckery.[extracts] " China's book on Chinese herbal medicine "
Chinese mugwort in thousand: [another name] Artemisia argyi Levl. et Van. var. argyi cv. Qiai, Coagulum Opuntiae sucus, Folium Crossostephii Chinensis, Bai Ai, white Folium Crossostephii Chinensis, beeweed, in vain Hibisci Mutabilis, Limonium wrightii Kuntz, rock head are white.[source] medical material Ji Yuan: be the leaf of feverfew Hibisci Mutabilis chrysanthemum.[nature and flavor] acrid in the mouth; Bitter; Slightly warm in nature.[function cures mainly] dispersing wind and cold; Reduce phlegm dampness removing; Removing toxic substances and promoting subsidence of swelling.Main anemofrigid cold; Cough with copious phlegm; Pertussis; Have loose bowels; Stranguria with turbid discharge; Leucorrhea; Carbuncle furunculosis.[extracts] " China's book on Chinese herbal medicine "
Pedicellus Luffae: [another name] sweet Pedicellus Luffae.[source] medical material Ji Yuan: be the Pedicellus Melo of dicotyledon medicine cucurbitaceous plant Fructus Luffae or Guangdong Fructus Luffae.[nature and flavor] bitter in the mouth; Cold nature.[function cures mainly] heat-clearing and toxic substances removing; To reduce phlegm arresting convulsion.Main variola does not rise; Laryngopharynx swelling and pain; Demented; Epilepsy syndrome.[extracts] " China's book on Chinese herbal medicine "
Radix of Aloe: [source] medical material Ji Yuan: be the root of liliaceous plant stripe aloe vera etc.[nature and flavor] sweet in the mouth; Light; Cool in nature.[return through] spleen; Stomach; Urinary bladder channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Blood stasis dispelling.Main infantile malnutrition; Urinary tract infection.[extracts] " China's book on Chinese herbal medicine "
Herba Ludwigiae Prostratae: the sub-knotweed of [another name] fourth, red cow pea, trumpetweed, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp., Herba Ludwigiae Prostratae, water pad in shoe is young, Rheum alexandrae Batal. is numb, Radix Homonoiae Ripariae, field Herba polygoni hydropiperis, ambary grass, silver-colored Herba mesonae chinensis, field painful abdominal mass grass, water Borax, water spunyarn, mountain Mus melon, water borax.[source] medical material Ji Yuan: be the herb of onagraceae plant Herba Ludwigiae Prostratae.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Inducing diuresis for treating stranguria syndrome; Removing stasis to stop bleeding.Main cough due to lung-heat; Laryngopharynx swelling and pain; Conjunctival congestion and swelling pain; Damp-heat dysentery; Jaundice; Drench pain; Edema; Leukorrhagia; Spit blood; Hematuria; Discharging fresh blood stool; Furuncle swells; Scabies; Traumatic injury wound is swollen; Traumatic hemorrhage; Snakeworm, lyssodexis.[extracts] " China's book on Chinese herbal medicine "
Radix Buddlejae Butterflybush: [another name] MANSHANXIANG.[source] medical material Ji Yuan: be root, the leaf of Pittosporaceae plant platform Qionghai paulownia.[function cures mainly] promoting blood circulation and detumescence, removing toxic substances dysentery relieving.Main traumatic injury, dysentery.[extracts] " China's book on Chinese herbal medicine "
Herba Alismatis Canaliculati: [another name] marshy land is rushed down, antiperspirant rifle arrow.[source] medical material Ji Yuan: be the herb of Notes On Alism At Aceae alisma canaliculatum.[nature and flavor] are lightly seasoned; Cold nature.[return through] lung; Kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main urinary obstruction; Edema; Innominate toxic swelling; Skin bleb; Eczema; Venom.[extracts] " China's book on Chinese herbal medicine "
Rhizoma et Radix Doellingeriae (Herba Doellingeriae): [another name] celestial Pennisetum centrasiaticum Tzvel, celestial clam reed, interwined dragon grass, careless, the sharp leaf Herba Ixeritis chinensis of white clouds, Chinese cabbage, lobule is blue or green, Flos Chrysanthemi secretly disappears, stomach medicine, mountain clam reed, male and female sword, Radix Sarumatis henryi, inflammation dish, YEYUTOU, brill culpeo, pimple medicine, careless Radix Notoginseng, native Rhizoma Cynanchi Stauntonii.[source] medical material Ji Yuan: be rhizome and the herb of feverfew Rhizoma et Radix Doellingeriae (Herba Doellingeriae) and Doellingeria marchandii (Levl) Ling..[nature and flavor] acrid in the mouth; Sweet; Property is micro-.[function cures mainly] heat-clearing and toxic substances removing; Improving eyesight; Sore-throat relieving.Main anemopyretic cold; Headache and dizziness; Conjunctival congestion and swelling pain; Pharyngitis; Acute kidney fire; Pneumonopathy is spitted blood; Traumatic injury; Carbuncle furuncle; Venom.[extracts] " China's book on Chinese herbal medicine "
Radix Fici tikouae: [source] medical material Ji Yuan: be the root of moraceae plants Radix Pachyrhizi Erosi banyan.[nature and flavor] are bitter; Puckery; Cool in nature.[return through] spleen; Kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Reducing swelling and alleviating pain.Master has loose bowels; Dysentery; General edema with yellowish skin; Rheumatic arthralgia; Seminal emission; Carry; Scrofula; Hemorrhoid; Toothache; Traumatic pain.[extracts] " China's book on Chinese herbal medicine "
Folium Agaves variegatae: [another name] Oxyria sinensis Hemsl., golden-rimmed false Fructus Ananadis comosi, Folium Agaves variegatae, yellow limit Folium Agaves variegatae.[source] medical material Ji Yuan: be the leaf of Agavaceae plant Folium Agaves variegatae.Gather and store: the whole year all can adopt, using fresh herb or scald after dry.[nature and flavor] are sweet; Micro-pungent; Cool.[function cures mainly] nourishing the lung to arrest cough; Cooling blood for hemostasis; Heat-clearing and toxic substances removing.Main xeropulmonary cough; Spitting of blood; Dyspnea due to deficiency; Measles without adequate eruption; Carbuncle sore tumefacting virus; Burn and scald.[each discussion] 1. " conventional glossary of Herbs and Drugs among the people ": eliminating phlegm to relieve asthma.Control cough to spit blood.2. " Nanning City's medicine will ": have promoting tissue regeneration by removing blood stasis effect.Control lung gastrorrhagia.Skin infection is controlled in external application.3. " Chengdu Chinese herbal medicine ": heat clearing away, lung moistening, hemostasis.[extracts] " China's book on Chinese herbal medicine "
Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae): [another name] rescues army provisions, red fruit, Chinese firethom, torch fruit, Fructus Pyracanthae, Fortune Firethorn Fruit, water sand, bean gold ma, little Fructus Pyracanthae, fiery sour jujube.[source] medical material Ji Yuan: be the fruit of rosaceous plant fire sour jujube.[nature and flavor] are sweet; Acid; Puckery; Flat; Nontoxic.[return through] liver; Spleen; Stomach warp.[function cures mainly] spleen invigorating removing food stagnancy; Convergence dysentery relieving; Pain relieving.Main mass in the abdomen; Food stagnation is stagnated; Distension and fullness in the abdomen; Have loose bowels; Dysentery; Metrorrhagia; Leukorrhagia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Melastomatis Candii: [another name] pig Herba Linderniae Crustaceae, Catunaregam spinosa (Thunb.) Tirveng., Herba Melastomatis Candii, leopard tooth Lang Mu, HUOXUEDAN, high foot mountain fall Soviet Union, gulp down mouth bar, felt bar, hair foot bar, balaustine, gold pomegranate, golden pheasant lower limb, pig Soft-Fleece harvests, cattle Soft-Fleece harvests, red quick-fried tooth wolf, tank switching grass, high foot harvests, Pu pen young, nine spiral shells son flowers, do not stay year, high foot Pu pears, large size sky kind stove outside row, great Du bridge, water.[source] medical material Ji Yuan: be the herb of Melastomateae plants Herba Melastomatis Candii.Gather and store: autumn excavates Herb, cleaning, chopping, dries.[nature and flavor] sour in the mouth; Puckery; Cool in nature.[return through] returns spleen; Stomach; Lung; Liver Channel.[function cures mainly] removing food stagnancy dampness removing, promoting blood circulation and hemostasis; Heat-clearing and toxic substances removing.Staple food amasss; Let out dysentery; Hepatitis; Treating swelling and pain by traumatic injury; Traumatic hemorrhage; Epistaxis; Hemoptysis; Spit blood; Have blood in stool; Menorrhagia; Metrorrhagia; Puerperal abdonimal pain; Leucorrhea; Milk laxation; Thromboangiitis; Intestinal carbuncle; Skin ulcer swells; Venom.[extracts] " China's book on Chinese herbal medicine "
Grass Radix Angelicae Pubescentis: [another name] little Radix Delphinii pogonanthi, NIUJIAOQI, JIUGUNIU, Radix Ariliae, energetically stock cattle, power stock cattle, pearl money grass, Colophonium infantile malnutrition medicine.[source] medical material Ji Yuan: be the root of Araliaceae Yunnan Radix Ariliae.[nature and flavor] bitter in the mouth; Pungent; Slightly warm in nature.[function cures mainly] dispersing wind-cold; Invigorating spleen for diuresis; Relaxing muscles and tendons to promote blood circulation; Preventing the attack (or recurrence) of malaria.Main anemofrigid cold; Cough; Edema due to deficiency of the spleen; Infantile malnutrition; Pain in chest and hypochondrium; Treating swelling and pain by traumatic injury; Rheumatalgia; Lumbago; Fracture; Menoxenia; Traumatic hemorrhage; Malaria.[extracts] " China's book on Chinese herbal medicine "
Plantula Brassicae chinensis: [another name] Chinese cabbage, summer ancient name for Chinese cabbage, green vegetable.[source] medical material Ji Yuan: be the leaf of crucifer green vegetable.[nature and flavor] are sweet; Cool.[return through] intestinal; Stomach warp.[function cures mainly] antipyretic relieving restlessness; Promoting the production of body fluid to quench thirst; Lung heat clearing expectorant; Tonneau the intestines and stomach.Main cough due to lung-heat; Constipation; Quench one's thirst; Food stagnation; Erysipelas; Dermatitis rhus.[extracts] " China's book on Chinese herbal medicine "
Fructus Mali Asiaticae: the bright fruit of [another name] galaxy of literary talent, golden woods fowl, red woods fowl, water woods fowl, thick forest fowl, black woods fowl, come fowl, frequently mother-in-law fruit, galaxy of literary talent fruit, Zhu's a kind of apple, multicolored Fructus Mali Asiaticae, join pearl fruit, premium fruit, premium, Fructus Mali Asiaticae, mamoncillo, multicolored a kind of apple.[source] medical material Ji Yuan: be the fruit of rosaceous plant premium.[nature and flavor] are sour, sweet; Temperature; Nontoxic.[return through] heart; Liver; Lung meridian.[function cures mainly] expel flatulence and relieve chest stuffiness, promoting the production of body fluid to quench thirst, relieving pain by regulating middle-JIAO.Main phlegm retention food stagnation, chest and diaphragm painful abdominal mass plug, quenches one's thirst, cholera, stomachache of vomiting and diarrhoea, dysentery.[extracts] " China's book on Chinese herbal medicine "
Radix Puerariae Omeiensis: [another name] pueraria omeiensis Wang et Tang, bitter Pueraria lobota.[source] medical material Ji Yuan: be the root of leguminous plant pueraria omeiensis Wang et Tang.[nature and flavor] are pungent; Bitter; Flat.[return through] lung; Stomach warp.[function cures mainly] clearing heat for promoting eruption; Promoting the production of body fluid to quench thirst.Main cold, fever; Measles without adequate eruption; Quench one's thirst; Spit blood; Aphtha.[extracts] " China's book on Chinese herbal medicine "
Herba Triglochinis: [source] medical material Ji Yuan: be the herb of Juncaginaceae plant Triglochin Maritimum L..[nature and flavor] sweet in the mouth; Property is put down.[return through] lung; Stomach; Kidney channel.[function cures mainly] clearing away heat and promoting production of body fluid; Detoxification and promoting urination.Main intenseness of heat impairment of body fluid; Gastric heat excessive thirst; Urine leaching pain.[extracts] " China's book on Chinese herbal medicine "
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Herba Turczaninowiae Fastigiatae 20 ~ 30 parts, Chinese mugwort in thousand 10 ~ 20 parts, Pedicellus Luffae 15 ~ 25 parts, Radix of Aloe 20 ~ 30 parts, Herba Ludwigiae Prostratae 10 ~ 20 parts, Radix Buddlejae Butterflybush 10 ~ 20 parts, Herba Alismatis Canaliculati 5 ~ 15 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 ~ 30 parts, Radix Fici tikouae 10 ~ 20 parts, Folium Agaves variegatae 20 ~ 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 20 ~ 30 parts, Herba Melastomatis Candii 30 ~ 40 parts, careless Radix Angelicae Pubescentis 15 ~ 25 parts, Plantula Brassicae chinensis 10 ~ 20 parts, Fructus Mali Asiaticae 10 ~ 20 parts, Radix Puerariae Omeiensis 15 ~ 25 parts and Herba Triglochinis 10 ~ 20 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can also be preferably as follows: Herba Turczaninowiae Fastigiatae 20 ~ 25 parts, Chinese mugwort in thousand 15 ~ 20 parts, Pedicellus Luffae 18 ~ 23 parts, Radix of Aloe 22 ~ 27 parts, Herba Ludwigiae Prostratae 13 ~ 18 parts, Radix Buddlejae Butterflybush 10 ~ 15 parts, Herba Alismatis Canaliculati 8 ~ 13 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 ~ 25 parts, Radix Fici tikouae 13 ~ 18 parts, Folium Agaves variegatae 25 ~ 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 22 ~ 27 parts, Herba Melastomatis Candii 30 ~ 35 parts, careless Radix Angelicae Pubescentis 17 ~ 22 parts, Plantula Brassicae chinensis 15 ~ 20 parts, Fructus Mali Asiaticae 12 ~ 17 parts, Radix Puerariae Omeiensis 18 ~ 23 parts and Herba Triglochinis 13 ~ 18 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine also can be preferably as follows: Herba Turczaninowiae Fastigiatae 22 parts, Chinese mugwort in thousand 18 parts, Pedicellus Luffae 20 parts, Radix of Aloe 26 parts, Herba Ludwigiae Prostratae 14 parts, Radix Buddlejae Butterflybush 15 parts, Herba Alismatis Canaliculati 12 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 parts, Radix Fici tikouae 16 parts, Folium Agaves variegatae 26 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 26 parts, Herba Melastomatis Candii 32 parts, careless Radix Angelicae Pubescentis 20 parts, Plantula Brassicae chinensis 16 parts, Fructus Mali Asiaticae 17 parts, Radix Puerariae Omeiensis 20 parts and Herba Triglochinis 17 parts.
Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows again: Herba Turczaninowiae Fastigiatae 24 parts, Chinese mugwort in thousand 15 parts, Pedicellus Luffae 22 parts, Radix of Aloe 24 parts, Herba Ludwigiae Prostratae 18 parts, Radix Buddlejae Butterflybush 10 parts, Herba Alismatis Canaliculati 9 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 24 parts, Radix Fici tikouae 14 parts, Folium Agaves variegatae 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 24 parts, Herba Melastomatis Candii 34 parts, careless Radix Angelicae Pubescentis 18 parts, Plantula Brassicae chinensis 20 parts, Fructus Mali Asiaticae 12 parts, Radix Puerariae Omeiensis 23 parts and Herba Triglochinis 14 parts.
Wherein, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: powder
Get Herba Turczaninowiae Fastigiatae 240g, Chinese mugwort 150g, Pedicellus Luffae 220g, Radix of Aloe 240g, Herba Ludwigiae Prostratae 180g, Radix Buddlejae Butterflybush 100g, Herba Alismatis Canaliculati 90g, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 240g, Radix Fici tikouae 140g, Folium Agaves variegatae 300g, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 240g, Herba Melastomatis Candii 340g, careless Radix Angelicae Pubescentis 180g, Plantula Brassicae chinensis 200g, Fructus Mali Asiaticae 120g, Radix Puerariae Omeiensis 230g and Herba Triglochinis 140g in thousand;
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 10 hours, with slow fire boiling, decocting time is 4 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours, filters acquisition second filtrate, and the quality of the water added is 3 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 100 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 20%, and by the material pouch subpackage after mixing, every 10 grams is one bag of subpackage.
Embodiment 2: capsule
Get Herba Turczaninowiae Fastigiatae 220g, Chinese mugwort 180g, Pedicellus Luffae 200g, Radix of Aloe 260g, Herba Ludwigiae Prostratae 140g, Radix Buddlejae Butterflybush 150g, Herba Alismatis Canaliculati 120g, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 200g, Radix Fici tikouae 160g, Folium Agaves variegatae 260g, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 260g, Herba Melastomatis Candii 320g, careless Radix Angelicae Pubescentis 200g, Plantula Brassicae chinensis 160g, Fructus Mali Asiaticae 170g, Radix Puerariae Omeiensis 200g and Herba Triglochinis 170g in thousand;
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.2:0.4, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 22 ~ 36g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese powder medicine prepared by embodiments of the invention 1, (concentration is 7.26g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage powder LD50>36.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.103g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 29g) oral administration gavage Chinese medicine of the present invention is 705 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 powder of the present invention to three groups of mices (often organize 15) by 13.25,19.36 and 32.65g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Patient data: select in April, 2013 ~ 2014 year December inpatient 80 example, man 53 example, female 27 example, 20 ~ 68 years old age; Gastric ulcer 38 example, duodenal ulcer 42 example; Simple melena 44 example, melena companion hematemesis 36 example; Stool blood: (+) person 18 example, (++) person 21 example, (+++) person 22 example, (++++) person 19 example.80 routine patients are divided into treatment group and matched group at random.Treatment group 40 example, man 26 example, female 14 example, 20 ~ 66 years old age; Gastric ulcer 19 example, duodenal ulcer 21 example; Simple melena 21 example, melena companion hematemesis 19 example; Stool blood: (+) person 10 example, (++) person 11 example, (+++) person 10 example, (++++) person 9 example.Matched group 40 example, man 27 example, female 13 example, 21 ~ 68 years old age; Gastric ulcer 19 example, duodenal ulcer 21 example; Simple melena 23 example, melena companion hematemesis 17 example; Stool blood: (+) person 8 example, (++) person 10 example, (+++) person 12 example, (++++) person 10 example.Two groups of cases are all in the lower visible stomach of gastroscope direct-view or duodenal ulcer companion active hemorrhage.Two groups of ages, diseased region, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).
Case selection standard: have typical stomach or duodenal bulbar ulcer (A1 phase) clinical symptoms, with melena and/or hematemesis for main clinic symptoms, can with chronic, periodically, regular Upper abdominal pain or stomachache etc., gastroscopy can find gastric ulcer or duodenal bulb chamber ulcer, and has active hemorrhage or hemorrhage rear blood crusts adhere to or see the blood vessel having bottom ulcer and appear.Get rid of malignant tumor patient, gestation or women breast-feeding their children, non-ulcerative digestive tract hemorrhage, severe bleeding or hemorrhagic gastritis and esophageal vein Rupture haemorrhag person etc.
Therapeutic Method:
Treatment group: take powder prepared by the embodiment of the present invention 1, each 20g, every day 3 times.
Matched group: omeprazole 40mg adds normal saline 100ml iv drip, every day 2 times.
Curative effect judging standard: effective: in treatment 48h, hematemesis and/or melena stop, steadily, stool blood is negative, and gastroscopy is without fresh hemorrhage sign for blood pressure and pulse.Effective: after treatment 48h, hematemesis and/or melena stop or obviously alleviating, and normally, gastroscopy is without active hemorrhage for blood pressure and pulse.Invalid: after treatment 72h, hematemesis and/or melena are without alleviating or increasing the weight of, and blood pressure and pulse wave, gastroscopy still has fresh hemorrhage, need change operation into and wait the treatment of other method.
Therapeutic outcome: two groups treat 5 days respectively after, treatment situation statistics in table 1.
Table 1 liang group comparitive study (example/%)
| Group | Number of cases | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 40 | 31 | 8 | 1 | 39(97.5％) |
| Matched group | 40 | 21 | 12 | 7 | 33(82.5％) |
Known by table 1, Chinese medicine of the present invention, relative to Western medicine, can significantly improve haemostatic effect, shortens bleeding stopping period, simultaneously according to clinical observation, can also eliminate the clinical symptoms such as abdominal distention, stomachache, stomachache of patient fast.
Concrete case: high certain, man, 52 years old, be admitted to hospital first 3 days, be admitted to hospital because of abdominal pain and defecation black and see a doctor, be diagnosed as duodenal ulcer through gastroscopy and merge hemorrhage, stool blood (+++), give the powder of the oral embodiment of the present invention 1 preparation, each 20g, every day 3 times, take medicine hematemesis and melena after 24h stops, gastroscopy is without fresh hemorrhage sign, and the 2nd afternoon stool transfers yellow to, effective.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat the hemorrhage Chinese medicine of acute peptic ulcer for one kind, it is characterized in that, comprise following raw medicinal material: Herba Turczaninowiae Fastigiatae, Chinese mugwort, Pedicellus Luffae, Radix of Aloe, Herba Ludwigiae Prostratae, Radix Buddlejae Butterflybush, Herba Alismatis Canaliculati, Rhizoma et Radix Doellingeriae (Herba Doellingeriae), Radix Fici tikouae, Folium Agaves variegatae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Herba Melastomatis Candii, careless Radix Angelicae Pubescentis, Plantula Brassicae chinensis, Fructus Mali Asiaticae, Radix Puerariae Omeiensis and Herba Triglochinis in thousand.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Turczaninowiae Fastigiatae 20 ~ 30 parts, Chinese mugwort in thousand 10 ~ 20 parts, Pedicellus Luffae 15 ~ 25 parts, Radix of Aloe 20 ~ 30 parts, Herba Ludwigiae Prostratae 10 ~ 20 parts, Radix Buddlejae Butterflybush 10 ~ 20 parts, Herba Alismatis Canaliculati 5 ~ 15 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 ~ 30 parts, Radix Fici tikouae 10 ~ 20 parts, Folium Agaves variegatae 20 ~ 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 20 ~ 30 parts, Herba Melastomatis Candii 30 ~ 40 parts, careless Radix Angelicae Pubescentis 15 ~ 25 parts, Plantula Brassicae chinensis 10 ~ 20 parts, Fructus Mali Asiaticae 10 ~ 20 parts, Radix Puerariae Omeiensis 15 ~ 25 parts and Herba Triglochinis 10 ~ 20 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Turczaninowiae Fastigiatae 20 ~ 25 parts, Chinese mugwort in thousand 15 ~ 20 parts, Pedicellus Luffae 18 ~ 23 parts, Radix of Aloe 22 ~ 27 parts, Herba Ludwigiae Prostratae 13 ~ 18 parts, Radix Buddlejae Butterflybush 10 ~ 15 parts, Herba Alismatis Canaliculati 8 ~ 13 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 ~ 25 parts, Radix Fici tikouae 13 ~ 18 parts, Folium Agaves variegatae 25 ~ 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 22 ~ 27 parts, Herba Melastomatis Candii 30 ~ 35 parts, careless Radix Angelicae Pubescentis 17 ~ 22 parts, Plantula Brassicae chinensis 15 ~ 20 parts, Fructus Mali Asiaticae 12 ~ 17 parts, Radix Puerariae Omeiensis 18 ~ 23 parts and Herba Triglochinis 13 ~ 18 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Turczaninowiae Fastigiatae 22 parts, Chinese mugwort in thousand 18 parts, Pedicellus Luffae 20 parts, Radix of Aloe 26 parts, Herba Ludwigiae Prostratae 14 parts, Radix Buddlejae Butterflybush 15 parts, Herba Alismatis Canaliculati 12 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 20 parts, Radix Fici tikouae 16 parts, Folium Agaves variegatae 26 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 26 parts, Herba Melastomatis Candii 32 parts, careless Radix Angelicae Pubescentis 20 parts, Plantula Brassicae chinensis 16 parts, Fructus Mali Asiaticae 17 parts, Radix Puerariae Omeiensis 20 parts and Herba Triglochinis 17 parts.
5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Turczaninowiae Fastigiatae 24 parts, Chinese mugwort in thousand 15 parts, Pedicellus Luffae 22 parts, Radix of Aloe 24 parts, Herba Ludwigiae Prostratae 18 parts, Radix Buddlejae Butterflybush 10 parts, Herba Alismatis Canaliculati 9 parts, Rhizoma et Radix Doellingeriae (Herba Doellingeriae) 24 parts, Radix Fici tikouae 14 parts, Folium Agaves variegatae 30 parts, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 24 parts, Herba Melastomatis Candii 34 parts, careless Radix Angelicae Pubescentis 18 parts, Plantula Brassicae chinensis 20 parts, Fructus Mali Asiaticae 12 parts, Radix Puerariae Omeiensis 23 parts and Herba Triglochinis 14 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the filtering residue quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;
5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920486A (en) * | 2016-06-20 | 2016-09-07 | 柳春华 | Traditional Chinese medicine for treating juvenile bronchial asthma and method of preparation for same |
| CN112353729A (en) * | 2020-12-02 | 2021-02-12 | 湖南省中医药研究院 | Toothpaste for relieving oral ulcer and relieving swelling and pain and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520575A (en) * | 2013-10-18 | 2014-01-22 | 谭洪武 | Chinese medicinal preparation for treating spleen-stomach damp-heat type chronic gastritis and preparation method thereof |
| CN104888174A (en) * | 2015-06-16 | 2015-09-09 | 刘玉芝 | Medicinal preparation for treating deficiency cold of spleen and stomach type peptic ulcer and preparation method thereof |
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2015
- 2015-10-10 CN CN201510653888.3A patent/CN105147956A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520575A (en) * | 2013-10-18 | 2014-01-22 | 谭洪武 | Chinese medicinal preparation for treating spleen-stomach damp-heat type chronic gastritis and preparation method thereof |
| CN104888174A (en) * | 2015-06-16 | 2015-09-09 | 刘玉芝 | Medicinal preparation for treating deficiency cold of spleen and stomach type peptic ulcer and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920486A (en) * | 2016-06-20 | 2016-09-07 | 柳春华 | Traditional Chinese medicine for treating juvenile bronchial asthma and method of preparation for same |
| CN112353729A (en) * | 2020-12-02 | 2021-02-12 | 湖南省中医药研究院 | Toothpaste for relieving oral ulcer and relieving swelling and pain and preparation method thereof |
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