CN103751716A - Pharmaceutical composition for treating kidney stone and gall stone - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating kidney stone and gall stone. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 12-24 parts of Lysimachia christinae Hance, 12-24 parts of Lygodium japonicum, 12-24 parts of endothelium corneum gigeriae galli, 12-24 parts of radix curcumae, 12-24 parts of pyrrosia lingua, 9-21 parts of oriental wormwood, 9-21 parts of dianthus superbus, 9-21 parts of polygonum cuspidatum, 9-21 parts of rhizoma corydalis, 9-21 parts of salviae miltiorrhizae, 9-21 parts of desert cistanche, 9-21 parts of dodder, 9-21 parts of talcum powder, 9-21 parts of pangolin scales and 9-21 parts of spina gleditsiae. The defects of conventional medicines for treating the kidney stone and gall stone are overcome, and the invention provides a pharmaceutical composition with good effects for treating kidney stone and gall stone.

Description

A kind of pharmaceutical composition for the treatment of renal calculus and cholelithiasis

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of renal calculus and cholelithiasis.

Background technology

Renal calculus as its name suggests, is exactly that kidney the inside has grown " stone ".In each organ of urinary system, the normally lithogenous position of kidney.Renal calculus is one of common disease of urinary system, in every 20 people, just has one may suffer from renal calculus.The forming process of renal calculus, is to cause in urine crystalline solid concentration to raise or dissolubility reduces because of some factor, is hypersaturated state, and crystallization in local growth, gathering finally forms calculus.According to the difference of stone composition, renal calculus can be divided calcium oxalate stone, calcium phosphate stone, uric acid (urate) calculus, struvite calculus, cystine stone and purine calculus six classes.Most of calculus can be mixed two or more composition.At present, the Therapeutic Method of renal calculus has multiple, as the form of performing the operation, adopt extracorporeal shock-wave lithotomy or non-open operation to get stone, or several method is combined use and is obtained satisfactory effect, but these Therapeutic Method not only expense are high, and easily recurrence, a lot of doctor trained in Western medicine doctors advise the rubble of performing the operation, great majority have also been damaged to kidney in broken, once kidney is impaired, the way that doctor trained in Western medicine is more not good; Can also adopt medical treatment, conventional litholytic therapy, better to urate calculus and cystine stone curative effect, to poor containing calcium calculus and Infective calculus curative effect, that its route of administration has is oral, vein, intra-ureteral cannula, open kidney makes repeatly intubate and percutaneous renal puncture is made repeatly intubate etc.; Also there is the method for many employing treatment by Chinese herbs renal calculuss, if China Patent Publication No. is CN102727835A, a kind of medicine that is used for the treatment of renal calculus is disclosed, it is to be formed by the preparation of raw material of following weight portion: Radix Bupleuri (processed with vinegar) 3-10 part, Radix Paeoniae Alba 15-60 part, long-pending real 6-15 part, Rhizoma Cyperi (processed with vinegar) 5-15 part, CHUANJIZI 6-15 part, Radix Angelicae Sinensis 5-20 part, Radix Curcumae 5-15 part, Rhizoma Corydalis 5-15 part, Herba Lysimachiae 10-30 part, Spora Lygodii 10-30 part, Endothelium Corneum Gigeriae Galli 5-15 part, Semen Plantaginis 10-30 part, Folium Pyrrosiae 10-30 part, Radix Achyranthis Bidentatae 5-15 part, Radix Glycyrrhizae 3-6 part.For renal calculus, best with Chinese medicine from the old complaint treatment of getting on, need to overcome the Chinese medicine of conventional treatment renal calculus simultaneously, treatment time is long, curative effect is not very desirable shortcoming.

Cholelithiasis, is also commonly encountered diseases, people's depressed, angry, rage for a long time, eat more rich, few motion, operating pressure large, tired, stay up late, do not have breakfast or diet variable interval is the inducement that cholelithiasis forms.Because above factor stimulates and disturbed the vagus nerve of human body, cause the propagation function wadding of vagal efferent fiber and centripetal fiber disorderly, cause that parasympathetic nervous too suppresses, too electric discharge, cell cultured supernatant secretion of bile is too much, gastrointestinal motility increased functionality, Amount of Bile increases, and the cholate in bile or bile acid, cholesterol, the synthetic minimizing of lecithin, cause cholesterol deposits to get off and form crystal, cause the cholesterol calculus of biliary tract or gallbladder, that is cholelithiasis.

Cholelithiasis, along with the change of human lives's custom and dietary structure, the sickness rate of gallstone disease is in rising trend, it is the more refractory commonly encountered diseases of one, its Symptoms: upper right abdominal distention and pain, its distending pain can emit to right shoulder and back, and with low grade fever, feel sick, detest greasy food, vomiting, shiver with cold, dripping sweat and even occur jaundice.Gallstone disease is also not quite similar in the cause of disease, clinical symptoms, treatment, disease prevention.The method for the treatment of cholelithiasis has operative therapy and non-operative treatment at present, operative therapy is mainly out abdomen excision cholelithiasis, excise one's gallbladder or stone is got by Wicresoft, make patient not only will bear the misery of operation, while has lacked a gallbladder compared with normal person or gallbladder damages, be there is to very large impact in life in the future, operative therapy is directly obvious, but to patient, cause wound and the misery of operation, medical expense is also relatively high, be in a bad way and just can take modus operandi treatment, and serious symptom person is as needed surgical calculus removing, but there is hypertension, coronary heart disease, the patient that the patients such as diabetes can not perform a surgical operation, can only adopt non-operative treatment, therefore operative therapy has certain restricted.Non-operative treatment mainly contain blast wave stone-breaking and medicine calculus dissolving and excreting therapy, blast wave stone-breaking scheme has certain effect to rubble, but easily injures surrounding tissue, and liver and peripheral organs are damaged.Drug therapy, doctor trained in Western medicine adopts ursodesoxycholic acid more, and the direct function of gallbladder promoting of the sharp liver medicine such as trepibutone, can only take stopgap measures and can not effect a permanent cure, and on often delay treatment opportunity, aggravates disease.The medicine lithodialysis such as oral cholic acid, after oral cholic acid, people just can be expanded in bile acid pond, and hepatic secretion cholesterol reduces, and gallbladder inner cholesterol calculus likely obtains dissolving and disappears, but this medicine has certain toxic reaction to liver.Treatment by Chinese herbs cholelithiasis is selection very carefully.

In sum, treatment renal calculus and cholelithiasis needed a kind of effective, instant effect, the little Chinese medicine composition of side effect badly.

Summary of the invention

The technical problem to be solved in the present invention is the deficiency that overcomes existing treatment renal calculus and cholelithiasis medicine, and a kind of pharmaceutical composition that has better effects to treating renal calculus and cholelithiasis is provided.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, by the raw material of following weight parts, is made:

Herba Lysimachiae 12-24 part, Spora Lygodii 12-24 part, Endothelium corneum 12-24 part, Radix Curcumae 12-24 part, Folium Pyrrosiae 12-24 part, Herba Artemisiae Scopariae 9-21 part, Herba Dianthi 9-21 part, Rhizoma Polygoni Cuspidati 9-21 part, Rhizoma Corydalis 9-21 part, Radix Salviae Miltiorrhizae 9-21 part, Herba Cistanches 9-21 part, Semen Cuscutae 9-21 part, Pulvis Talci 9-21 part, Squama Manis 9-21 part, Spina Gleditsiae 9-21 part.

Preferably, it is to be made by weight by following raw materials according:

Herba Lysimachiae 15-21 part, Spora Lygodii 15-21 part, Endothelium corneum 15-21 part, Radix Curcumae 15-21 part, Folium Pyrrosiae 15-21 part, Herba Artemisiae Scopariae 12-18 part, Herba Dianthi 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Rhizoma Corydalis 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Herba Cistanches 12-18 part, Semen Cuscutae 12-18 part, Pulvis Talci 12-18 part, Squama Manis 12-18 part, Spina Gleditsiae 12-18 part.

More preferably, it is to be made by weight by following raw materials according:

18 parts of Herba Lysimachiaes, 18 parts of Spora Lygodii, 18 parts of Endothelium corneum, 18 parts of Radix Curcumaes, 18 parts of Folium Pyrrosiaes, 15 parts of Herba Artemisiae Scopariaes, 15 parts of Herba Dianthis, 15 parts of Rhizoma Polygoni Cuspidati, 15 parts of Rhizoma Corydalis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Cistanchess, 15 parts of Semen Cuscutae, 15 parts of Pulvis Talci, 15 parts of Squama Manis, 15 parts of Spina Gleditsiae.

The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage forms such as capsule, granule, pill, tablet, decoction, and their preparation method, supplementary product consumption are undertaken by existing common process.

The present invention also comprises the application of aforementioned pharmaceutical compositions in the medicine of preparation treatment renal calculus and cholelithiasis.

The traditional Chinese medical science is thought: the main cause that causes renal calculus is " kidney-heat fire-transformation calculogenesis ", and obstinate, and medication is mainly with eliminating damp-heat, Tonglin Paishi, and cooling blood for hemostasis is main.

The traditional Chinese medical science is thought: cholelithiasis is by damp and hot love liver and gall of a specified duration, accumulates steaming both of a specified duration, damp and hotly in irritability bile, ties mutually, form the disease of courage pent-up, damp and hot Kui resistance liver and gall, irritability is lost and is dredged, gallbladder loses logical falling, and causes irritability bile and damp-heat accumulation, and biliary tract must not tonneau, retardance mechanism of qi, gas must not fall, instead from superinverse, the violent angor of right upper quadrant of the abdomen paroxysmal, is radiated to the shoulder back of the body, alternate attack of chill and fever sometimes, fear of cold hyperpyrexia, heating bitter taste.Desire for cold drinks, yellow urine is as orange, constipation.Suffer from cholelithiasis and just answer the dialectical disease for deficiency in origin and excess in superficiality, due to stagnation of QI due to depression of the liver, catharsis is not normal, affects secretion and the excretion of bile, the resistance of bile addiction, addiction heat-transformation of a specified duration, the with the passing of time poly-stone that forms of knot.

In pharmaceutical composition prescription of the present invention:

Herba Lysimachiae, another name Lysimachia christinae Hance, DIWUGONG, Herba pteridis vittatae, the Hemerocallis citrina Baroni grass etc. of passing by one's way, is herb or the whole herb with root of Bao Chonghua section plant Lysimachia christinae Hance.Composition: 1. Lysimachia christinae Hance herb is containing phenolic constituent, sterol, flavonoid, aminoacid, tannin, volatile oil and choline.2. put in gland Lysimachia christinae Hance herb and isolate potassium chloride and mixing saccharide, preliminary examination still has the reactions such as flavonoid, Saponin, glycoside, lactone and organic acid.Function cures mainly: heat clearing away, dampness removing, detumescence, removing toxic substances.The subcutaneous ulcer of harnessing the Yellow River, edema, cholelithiasis, renal calculus, vesical calculus, regurgitation is dysphagic, traumatic injury, furuncle swelling toxin.1. the Wang An minister in ancient times < < will > > that gathers medicinal herbs: " control regurgitation dysphagic, edema tympanites, HUANGBAI(sic) erysipelas, cloudy disease typhoid fever." 2. just square > > of < < vegetation: " except pathogenic wind toxic.Bite by rabid dog, smashes wine clothes.Leprosy, erysipelas, raw clothes, (outward) are coated with." 3. < < Traditional Chinese Medicine in Sichuan will > >: " clearing away heat from blood, clearing away lung-heat to relieve cough, consumer edema.Control renal calculus, cholelithiasis, traumatic injury and malaria." 4. < < Chongqing medical herbs > >: " control consumptive disease wound cough band blood.”

Spora Lygodii, another name left-hand rotation rattan ash (< < Traditional Chinese Medicine in Sichuan will > >), Spora Lygodii (< < Jiangxi medical herbs > >).For the ripe spore of Lygodiaceae plant Spora Lygodii.Phytomorph is " Herba lygodii " bar in detail.Composition: fatty oil, separately containing a kind of water soluble ingredient lygodin.Function cures mainly: heat-clearing and toxic substances removing, relieving stranguria by diuresis.Control urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.1. < < Jiayou Bencao > >: " main tonneau small intestinal.Fructus Gardeniae, gingival cyst of mucous gland in the newborn disappear, the Borax cold and heat of curing the wound are altogether mad, or ball or loose." 2. < < detailed outline > >: " control damp and hot generalized edema with distention of the chest and abdomen, urine pyretic stranguria, stranguria marked by chyluria, stranguria with blood, stranguria caused by urinary stone, pain in the penis, antipyretic poison." the 3. just > > of < < book on Chinese herbal medicine: " relieving stranguria by diuresis.Control man excessive turbid, woman's leukorrhagia.”

Endothelium corneum, is the cutin inwall of the gizzard of Phasianidae animal, is generally Endothelium Corneum Gigeriae Galli, Endothelium corneum Anseris domestica, Endothelium Corneum Anas domestica.Endothelium Corneum Gigeriae Galli one medicine comes from < < Sheng Nong's herbal classic > > the earliest, is the digestants in Chinese medicine.Its matter pine, section cutin, dry gizzard inwall, is similar round video disc shape, and if Endothelium Corneum Gigeriae Galli is and thicker, surface is blackish green or atropurpureus, slightly wrinkle.Gas raw meat, mildly bitter flavor.Cure mainly: control all a fishbone or other bone caught in the throat, dysphagic regurgitation of food from the stomach.

Radix Curcumae, another name Ma Shu (< < Tang materia medica > >), Huang Yu (the elegant > > of < < stone medicine) is the tuber of zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Composition: Radix Curcumae tuber is containing volatile oil 6.1%, wherein camphene 0.8%, Camphora 2.5%, sesquiterpene 65.5%, main is curcumene, and sesquiterpene alcohols 22% etc., also containing curcumin 0.3%, demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone, another starch-containing 30～40%, fatty oil 3%, rubber, weld, Eucarvone and phellandrene, its effective ingredient is p-tolyl-methyl methylol curcumin.Function cures mainly: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spits blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.1. < < property of medicine opinion > >: " control woman's stagnated blood epigastric pain caused by emotional factors, cold air knot is poly-, and warm vinegar rubs and takes it." 2. < < Tang materia medica > >: " main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound." 3. < < pearl sac > >: " the cool heart.”

4. Li Gao: " control YANG toxin syndrome and enter stomach, hematochezia is pain frequently.”

Folium Pyrrosiae, another name stone Zhe (< < herbal classic > >), stone skin (< < does not record > >), Folium Pyrrosiae (< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >), Phymatopsis griffithiana (Hook.) J. Sm., Shi Lan (< < detailed outline > >), life pulls (< < classification medical herbs > >), rainbow Rhizoma Acori Graminei, Shi Jian, pool sword (< < Fujian traditional herbal medicine > >), gold soupspoon, stone back of the body willow (< < Chinese crude drug handbook > >).For Plants of Polypodiaceae Folium Pyrrosiae, the leaf of pyrrosia sheareriChing, pyrrosia drakeanaChing, pyrrosia petiolosaChing, pyrrosiadavidii or pyrrosia gralla Ching.Composition: containing bracken triterpene (diploptene), Saponin, anthraquinone, flavone, cupreol.Function cures mainly: relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.1. < < herbal classic > >: " main consumptive fever pathogen, five difficulty in urinations are obstructed, diuresis water channel." 2. < < do not record > >: " the only tired therapeutic method to keep the adverse QI flowing downwards, logical bladder is full, mends five kinds of over strain, An Wuzang, removes aversion to wind, beneficial vital essence." 3. < < Japan hanako materia medica > >: " control and drench drop incontinence of urine." 4. < < Bencao Tujing > >: " fry end, cold wine is taken after mixing with liquid, and treats carbuncle on the back.”

Herba Artemisiae Scopariae, another name capillary wormwood, Herba Artemisiae Scopariae, Herba Artemisiae Sieversianae, floss Artemisia, monkey hair, be the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparia Waldst.et Kit. or Herba Artemisiae Scopariae Artemisia capillaris Thunb..During the high 6～10cm of seedling in spring, gather or tap when autumn, alabastrum grew up to, removing impurity and old stem, drying.The habit of gathering spring claims " capillary wormwood ", the title " Herba Artemisiae Scopariae " of tapping autumn.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.

Herba Dianthi, call huge sentence wheat (< < herbal classic > >), great Lan (< < does not record > >), mountain Herba Dianthi (< < prescriptions worth thousand gold > >), Fructus Nandinae Domesticae grass (< < Shengji Zonglu > >), shorn velvet flower (> > is wanted in the bun of < < medical center), Herba Commelinae Diffusae (< < Shandong Chinese medicine > >), for the wounded in the battle herb of pinkwort Herba Dianthi or Dianthus chinensis.Composition: the fresh careless moisture content 77.3% of Herba Dianthi, thick protein 2.62%, nitrogen-free extract 13.18%, crude fibre 4.95%, coarse ash 11.09%, phosphoric acid 0.13%.Also, containing retinoid material, its content is calculated as 0.3333% by vitamin A.In addition still containing a small amount of alkaloid.Diranthus chinensis is containing eugenol, phenethanol, benzyl benzoate, benzyl salicylate, methyl salicylate etc.Herb is containing Saponin, saccharide, vitamin.Root is containing Saponin.Function cures mainly: clearing away heat and promoting diuresis, removing blood stasis stimulates the menstrual flow.Control urinary obstruction, gonorrhea, edema, amenorrhea, carbuncle, conjunctival congestion is hidden from view, contamination sore.1. < < herbal classic > >: " all infirmity knots of main obstruction and rejection, urinary obstruction go out thorn, certainly carbuncle, improving eyesight removing nebula, broken tire of falling, under close blood." 2. < < do not record > >: " support kidney qi, contrary by bladder heresy, only cholera, long hair." 3. < < property of medicine opinion > >: " main five types of stranguria.”

Rhizoma Polygoni Cuspidati, another name piebaldism bamboo, acid cylinder bar, sour soup stalk, river muscle dragon, the speckle village, speckle cane root, Herba Rabdosiae Nervosae, yellow Radix Sanguisorbae, be Polygonaceae Polygonaceae plant polygonum cuspidatum Polygonum cuspidatum Sieb.et Zucc., dry rhizome and root.Character: this product mostly is cylindrical short section or irregular sheet, long 1～7cm, diameter 0.5-2.5cm.Crust sepia, has vertical wrinkle and mark of fibrous root, and tangent plane skin zone is thinner, woody part broadness, and brown color, ray irradiation shape, skin zone and woody part are more easily separated.In rhizome marrow, have every or be empty shape.Matter is hard.Feeble QI, mildly bitter flavor, puckery.Nature and flavor: micro-hardship, is slightly cold.1. < < does not record > >: tepor.2. < < property of medicine opinion > >: sweet in the mouth is flat, nontoxic.3. < < Amplification on Materia Medica > >: micro-hardship.4. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: bitter micro-puckery, be slightly cold.Gui Jing: return liver, gallbladder, lung meridian.Function with cure mainly: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.1. < < does not record > >: the main tonneau moon water, broken Liu mass resulting from the blood stasis knot.2. TAO Hong-Jing: main sudden and violent abdominal mass, wine stain takes it.3. < < property of medicine opinion > >: control large heat irritated, quench the thirst, diuresis, presses all pyretic toxicity.4. < < Bencao Shiyi > >: main air is between joint and blood stasis.Liquor takes it as wine.5. < < Japan hanako materia medica > >: after managing property stagnant blood not under, trusted subordinate's distension.Evacuation of pus, main furuncle carbuncle poison, married woman's bruise, flutters damage blood stasis, broken pathogenic wind toxic stagnation of QI.6. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: attack all toxic swellings, only have sore throat, diuresis, walks meridians.Control five types of stranguria nebulousurine, anal fistula, carbuncle sore, married woman's leucorrhea with red and white discharge.

Rhizoma Corydalis, another name Rhizoma Corydalis, is the tuber of Papaveraceae herbaceos perennial Rhizoma Corydalis.Meridian distribution of property and flavor: acrid, bitter, warm, return liver, spleen, heart channel.Effect: invigorate blood circulation, circulation of qi promoting, pain relieving.Application: be mainly used in all pain cards of stagnation of QI and blood.The pungent loose temperature of this product is logical, and " stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body." its analgesic effect is good, no matter which kind of pain card, all can compatibility application.Modern age is clinical is used for treating the spastic or non-spasmic pain of multiple internal organs, all has good therapeutic effect; Also there is the neuralgia of the leprosy controlled, and make local anesthesia operator with 0.2% corydaline injection.

Radix Salviae Miltiorrhizae, has another name called Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, and Arisaema balansae Engl. etc., are dicotyledon Labiatae, dry root and rhizome.Effect: Radix Salviae Miltiorrhizae has GUIXIN, Liver Channel.Can stasis-dispelling and pain-killing, promoting blood flow to regulate menstruation, lowering blood-fat and reducing weight, relieving restlessness clears away heart-fire.

Herba Cistanches, is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche (Cistanche deserticola Y.C.Ma), clinical in sterile with controlling insufficiency of kidney-YANG, emission and spermatorrhea, impotence and premature ejaculation, cold sperm, Chang Peiwu warming the kidney to activate YANG, the medicine of temperature compensation essence and blood; Control caused by liver and kidney deficiency, chills and pain of the waist and kness, muscles and bones unable, Chang Peiwu benefiting essence-blood, the medicine of bone and muscle strengthening.Nature and flavor: sweet in the mouth, salty, warm in nature.Energy kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.

Semen Cuscutae, is the seed of dicotyledon scammonia section plant Semen Cuscutae, southern Semen Cuscutae, cuscuta japonica Choisy etc., has the effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, solid tire stopping leak.

Pulvis Talci, this strain Talcum is through selected purification, pulverizing, dry making, for white or off-white color, fine, without the powder of grittiness, hands touches with soapy feeling.Odorless, tasteless.This product is not all dissolved in water, dilute hydrochloric acid or diluted sodium hydroxide solution.Meridian distribution of property and flavor: sweet, light, cold.Return bladder, lung, stomach warp.Function cures mainly: inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.

Squama Manis, another name big gun Squama Manis, stir-baked SQUAMA MANITIS etc.After generally being concocted by the scute of Manitis (Squama Manis), use.Concocting method has that burning, shortcake are processed, processed with vinegar, urine of baby boys are processed, fry, parching with earth, stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE.Its salty in the mouth, cold nature, returns Liver Channel, stomach warp.Energy blood circulation promoting and dispersing pathogen accumulation, the stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle are burst hard.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula etc.

Spina Gleditsiae, claims again Spina Gleditsiae, SPINA GLEDITSIAE, is the Spina jujubae of pulse family deciduous tree plant Gleditsia officinalis.This product nature and flavor are pungent, temperature, the special detumescence and apocenosis of merit, tcm clinical practice all has good therapeutic effect for swollen ulcer drug, generally show as pus not Cheng Zheke disappear, formed pus person can make it speed and burst.Modern times Anticancer is studied and is shown, Spina Gleditsiae has anticancer tumor-suppression activity.

The pure Chinese medicine composition of pharmaceutical composition of the present invention, for kidney tonifying spleen invigorating diuresis, expansion ureter, promotes promoting blood circulation to remove obstruction in the collateral, after calculus is worked, with comminuted discharge, strengthens immune function of human body and resistance against diseases, for calculus, has fabulous curative effect.This pharmaceutical composition is the result that inventor meticulously develops in conjunction with modern crafts TCM Recipe art in long-term practice, and renal calculus, cholelithiasis are had to fabulous effect.

The specific embodiment

With specific embodiment, the invention will be further described below, but the present invention is not limited to these embodiment.

Embodiment 1

Herba Lysimachiae 120g, Spora Lygodii 240g, Endothelium corneum 120g, Radix Curcumae 240g, Folium Pyrrosiae 120g, Herba Artemisiae Scopariae 210g, Herba Dianthi 90g, Rhizoma Polygoni Cuspidati 210g, Rhizoma Corydalis 90g, Radix Salviae Miltiorrhizae 210g, Herba Cistanches 90g, Semen Cuscutae 210g, Pulvis Talci 90g, Squama Manis 210g, Spina Gleditsiae 90g.

By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, when filtrate is concentrated into relative density and is 1.30(70 ℃, survey) extractum, the magnesium stearate adjuvant that adds conventional amount used, technique is made tablet routinely, specification 0.5g/ sheet.

Embodiment 2

Herba Lysimachiae 240g, Spora Lygodii 120g, Endothelium corneum 240g, Radix Curcumae 120g, Folium Pyrrosiae 240g, Herba Artemisiae Scopariae 90g, Herba Dianthi 210g, Rhizoma Polygoni Cuspidati 90g, Rhizoma Corydalis 210g, Radix Salviae Miltiorrhizae 90g, Herba Cistanches 210g, Semen Cuscutae 90g, Pulvis Talci 210g, Squama Manis 90g, Spina Gleditsiae 210g.

By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and when filtrate is concentrated into relative density and is 1.30(70 ℃, surveys) extractum, add appropriate cane sugar powder, routinely the agent of technique granulation.

Embodiment 3

Herba Lysimachiae 150g, Spora Lygodii 210g, Endothelium corneum 150g, Radix Curcumae 210g, Folium Pyrrosiae 150g, Herba Artemisiae Scopariae 180g, Herba Dianthi 120g, Rhizoma Polygoni Cuspidati 180g, Rhizoma Corydalis 120g, Radix Salviae Miltiorrhizae 180g, Herba Cistanches 120g, Semen Cuscutae 180g, Pulvis Talci 120g, Squama Manis 180g, Spina Gleditsiae 120g.

Take above each raw material, decoct with water twice, add for the first time 8 times of water gagings, decoct 2 hours, add for the second time 6 times of water gagings, decoct 1.5 hours, collecting decoction, filters, and obtains decoction.

Embodiment 4

Herba Lysimachiae 210g, Spora Lygodii 150g, Endothelium corneum 210g, Radix Curcumae 150g, Folium Pyrrosiae 210g, Herba Artemisiae Scopariae 120g, Herba Dianthi 180g, Rhizoma Polygoni Cuspidati 120g, Rhizoma Corydalis 180g, Radix Salviae Miltiorrhizae 120g, Herba Cistanches 180g, Semen Cuscutae 120g, Pulvis Talci 180g, Squama Manis 120g, Spina Gleditsiae 180g.

Take above each raw material, clean and dry, co-grinding is crossed 80 mesh sieves, adds making pellets by mixing medical powder with honey, obtains pill.

Embodiment 5

Herba Lysimachiae 180g, Spora Lygodii 180g, Endothelium corneum 180g, Radix Curcumae 180g, Folium Pyrrosiae 180g, Herba Artemisiae Scopariae 150g, Herba Dianthi 150g, Rhizoma Polygoni Cuspidati 150g, Rhizoma Corydalis 150g, Radix Salviae Miltiorrhizae 150g, Herba Cistanches 150g, Semen Cuscutae 150g, Pulvis Talci 150g, Squama Manis 150g, Spina Gleditsiae 150g.

By proportional quantity, take above each raw material, decoct with water twice, add for the first time 7 times of water gagings, decoct 1.5 hours, add for the second time 8 times of water gagings, decoct collecting decoction 1.5 hours, filter, when filtrate is concentrated into relative density and is 1.30(70 ℃, survey) extractum, add the dextrin adjuvant of conventional amount used, technique routinely, make capsule, 0.5g/ grain.

Experimental example: the clinical efficacy of pharmaceutical composition of the present invention to renal calculus

Experiment material: pharmaceutical composition prepared by the embodiment of the present invention 5.

Experiment place: the Guangxi Qinzhou hospital of traditional Chinese hospital.

1, case and method

2008-2013, connects and controls patient's 152 examples, male's 82 examples, and women's 70 examples, the age is in 22-69 year.Renal calculus diagnostic criteria: lower abdomen and left and right waist distending pain or involve that sample acute pain, ailing gonosome position, waist can not be unfolded, hematuria, painful urination, row do not go out urine etc.Doctor trained in Western medicine B ultrasonic is diagnosed as renal calculus, and calculus diameter is greater than 0.1 centimetre, regular shape, smooth surface, and with the renal pelvis renal calices person that is free on intracavity without being adhered, urinary tract is without obvious deformity, narrow and infect the fair person of renal function.

Usage and dosage: the embodiment of the present invention 5, capsule, every day 3 times, each 2, oral; 30d is 1 course for the treatment of, after drug withdrawal 1-3d, can carry out next course for the treatment of, is used in conjunction 3 courses for the treatment of.

2, efficacy determination

According to clinical symptom disappearance, be as the criterion, be divided into recovery from illness, effective, invalid.

Recovery from illness: clinical symptoms sign disappears, recovers normal, and pain disappearance is urinated normal, and indices recovers normal on inspection, and B ultrasonic confirms calculus discharge.

Effective: basic or most of disappearance of clinical symptoms sign, pain disappears substantially, urinates slightly not smooth, and majority parameters recovers normal on inspection, and B ultrasonic confirms that calculus part discharges.

Invalid: clinical symptoms sign is without improvement, and Index for examination has no improvement, before B ultrasonic confirms calculus position, quantity and treatment, contrast is without obviously changing.

3, curative effect is summed up

Therapeutic outcome: after finishing the course for the treatment of, the effective percentage of renal calculus early stage patient reaches 97.6%, mid-term, patient's effective percentage reached 94.6%, and the effective percentage of patients with terminal is 92.6%.A wherein course for the treatment of of early stage patient fundamental need, and 2-3 the course for the treatment of of middle and advanced stage needs of patients.

Experimental example: the clinical efficacy of pharmaceutical composition of the present invention to cholelithiasis

Experiment material: pharmaceutical composition prepared by the embodiment of the present invention 5.

Experiment place: the Guangxi Qinzhou hospital of traditional Chinese hospital.

1, case and method

2009-2013, connects and controls patient's 120 examples, male's 65 examples, and women's 55 examples, the age is in 18-72 year.Cholelithiasis diagnostic criteria: the visible calculus of ultrasound diagnosis gallbladder, part patient has inappetence, feels sick, the symptom such as distending pain in the chest and hypochondrium in various degree.

Usage and dosage: the embodiment of the present invention 5, capsule, every day 3 times, each 2, oral; 30d is 1 course for the treatment of, after drug withdrawal 1-3d, can carry out next course for the treatment of, is used in conjunction 2 courses for the treatment of.

2, efficacy determination

According to clinical symptom disappearance, be as the criterion, be divided into recovery from illness, effective, effective, invalid.

Recovery from illness: the disappearance of clinical symptoms sign, recover normal, pain disappears, and B ultrasonic confirms calculus discharge.

Effective: basic or most of disappearance of clinical symptoms sign, B ultrasonic confirms that calculus part diminishes.

Invalid: clinical symptoms sign is without improvement, and before B ultrasonic confirms calculus position, quantity and treatment, contrast is without obviously changing.

3, curative effect is summed up

?	Recovery from illness	Effective	Invalid	Effective percentage
					After the course for the treatment of	66	35	19	84.1%
After two courses for the treatment of	92	23	5	95.8%

Therapeutic outcome: treat after the course for the treatment of, most of patient (101 example) symptom is alleviated to some extent, ultrasound diagnosis, 84.2% above patient's calculus is dissolved and is diminished or move down, and has 66 routine patient's calculus to discharge, and accounts for 55% of total number of persons.Treat two courses for the treatment of, recovery from illness 92 examples, account for 76.7%, and effective percentage 95.8% is evident in efficacy.

Claims (4)

1. a pharmaceutical composition for the treatment of renal calculus and cholelithiasis, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

Herba Lysimachiae 12-24 part, Spora Lygodii 12-24 part, Endothelium corneum 12-24 part, Radix Curcumae 12-24 part, Folium Pyrrosiae 12-24 part, Herba Artemisiae Scopariae 9-21 part, Herba Dianthi 9-21 part, Rhizoma Polygoni Cuspidati 9-21 part, Rhizoma Corydalis 9-21 part, Radix Salviae Miltiorrhizae 9-21 part, Herba Cistanches 9-21 part, Semen Cuscutae 9-21 part, Pulvis Talci 9-21 part, Squama Manis 9-21 part, Spina Gleditsiae 9-21 part.

2. the pharmaceutical composition for the treatment of renal calculus according to claim 1 and cholelithiasis, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

Herba Lysimachiae 15-21 part, Spora Lygodii 15-21 part, Endothelium corneum 15-21 part, Radix Curcumae 15-21 part, Folium Pyrrosiae 15-21 part, Herba Artemisiae Scopariae 12-18 part, Herba Dianthi 12-18 part, Rhizoma Polygoni Cuspidati 12-18 part, Rhizoma Corydalis 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Herba Cistanches 12-18 part, Semen Cuscutae 12-18 part, Pulvis Talci 12-18 part, Squama Manis 12-18 part, Spina Gleditsiae 12-18 part.

3. the pharmaceutical composition for the treatment of renal calculus according to claim 1 and cholelithiasis, is characterized in that: this pharmaceutical composition be to be made by the raw material of following weight parts:

18 parts of Herba Lysimachiaes, 18 parts of Spora Lygodii, 18 parts of Endothelium corneum, 18 parts of Radix Curcumaes, 18 parts of Folium Pyrrosiaes, 15 parts of Herba Artemisiae Scopariaes, 15 parts of Herba Dianthis, 15 parts of Rhizoma Polygoni Cuspidati, 15 parts of Rhizoma Corydalis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Cistanchess, 15 parts of Semen Cuscutae, 15 parts of Pulvis Talci, 15 parts of Squama Manis, 15 parts of Spina Gleditsiae.

4. the application of the pharmaceutical composition described in any one in the medicine of preparation treatment renal calculus and cholelithiasis in claim 1-3.