CN104162093A - Traditional Chinese medicinal preparation for treating breast cancer, and preparation method thereof - Google Patents
Traditional Chinese medicinal preparation for treating breast cancer, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal preparation for treating the breast cancer, and a preparation method thereof. Effective components of the preparation are prepared by using raw materials comprising, by weight, 85-95 parts of honeycomb, 85-95 parts of pangolin, 145-155 parts of Chinese Sage Herb, 145-155 parts of Vaccaria segetalis, 145-155 parts of Chinese angelica, 145-155 parts of Radix Astragali, 145-155 parts of Rhizoma Curcumae, 145-155 parts of Poria cocos and 25-35 parts of Panax Notoginseng powder. The preparation method comprises the following steps: crushing the raw materials, mixing, immersing in cold water, carrying out steam distillation, extracting volatile oil, and reserving medicinal residues for later use; decocting the medicinal residues by raw medicine water three times, mixing the above collected three decoctions, concentrating the above obtained decoction mixture at 40-50DEG C to obtain a concentrate with the relative density of 1.5-1.6; and mixing the concentrate with the volatile oil, and packaging to obtain the traditional Chinese medicinal preparation for treating the breast cancer, wherein the preparation is an oral liquid. Function tests prove that the traditional Chinese medicinal preparation has a treatment effect on the breast cancer.
Description
Technical field
The present invention relates to mastadenoma medicine, especially a kind of Chinese medicine preparation for the treatment of breast carcinoma and preparation method thereof.
Background technology
Breast carcinoma is the malignant tumor that betides lobules of mammary gland and ductal epithelium, is the modal malignant tumor of women, the multiple women who is born in front and back in 40 to 60 years old menopause.The real pathogenic factor of primary disease is failed to understand, is commonly considered as endocrine disturbance, immunity degradation, and long-term psychentonia, and certain inherited genetic factors is the cause of disease of pathogenesis of breast carcinoma; And the factors such as viral infection, trauma of breast, inflammation, roentgenization, high fat diet and primary disease have substantial connection.
How asymptomatic breast carcinoma is in early days, along with the development of the state of an illness, may show part and General Symptoms.And different histological type, symptom and sign are also not quite similar.Common sympton is as follows: 1, Silent Neuritis lump: lump is infiltrative growth, and matter softening the hard mass is tough, obscure boundary Chu, great majority are single-shot, most lumps are positioned at outside upper quadrant, next Shi Neishangji nipple-areola district, below is less.Lump is not of uniform size, more common with 2～3 centimetres of sizes, occasionally can be multiple.The how rounded or oval of lump, border owes clearly, generally to be scleroma, and mobility is all poor.Can there is skin stellate ganglion in the later stage.Early stage many without pain, most patient with breast cancers lack pain symptom.Because pain generation is less, breast carcinoma is difficult for by early discovery.Pain often shows as mammary gland twinge, and distending pain or dull pain, as cancer week also can occur periodically pain with cystic hyperplasia of breast.Late period, pain was more violent.2, skin of breast changes: mammary gland tissue is positioned at subcutaneous superficial fascia and holds, and between depth fascia, by ligament, is connected.Because superficial fascia is connected with skin, when breast carcinoma invade and mammary gland between ligament while making it to shorten, can tractive skin, make local skin depression, as dimple, be referred to as " dimple sign ".Tumor is direct in addition and skin adhesion also may cause this kind of situation.Dimple sign can occur early time in breast carcinoma, more obvious when Ipsilateral arm is up and down.Rubescent and swelling: growth is very fast, the temperature rise of tumor by local skin, can appear that skin superficial vein anger opens, in the tumor that volume is larger.Skin ulceration: tumor development is to late period, and lump is grown up, can make cutaneous protuberance, and if blood is for not enough, along with skin rubefaction, attenuation, ulceration can occur.Patient often accompanies pain, and severe pain unbearably sometimes.Because wound surface has a large amount of sloughs and courageous and upright secretions, ooze out, therefore patient often occurs becoming thin, anemia sign.3, the eczema sample of nipple changes: be initially nipple pruritus, nipple epithelium thickens, desquamation, sepage, engenders erosion, rotten to the corn and repeatedly form a scab, cut de-, and skin of areola strips off the red granulation of rear appearance, and nipple can slowly flatten, and finally disappears.Nipple discharge: nipple discharge companion lump person, the large percentage that breast carcinoma is shared.Discharge can be colourless, milky, faint yellow, brown, courageous and upright etc.; Can be water sample, blood sample, serosity or pus; Discharge amount is the amount doesn't matter, and interval time is also inconsistent.4, lymphadenectasis: on oxter and clavicle, lymph is because of transfer enlargement.5, General Symptoms: become thin, the phenomenon such as anemia, cachexia.
For breast cancer treatment, first consider the western medical treatment of operative treatment, radiotherapy and chemotherapy clinically.Because lump is the modal onset symptoms of breast carcinoma, Most patients is stumbling on, treatment to breast carcinoma, Partial Hospitals is also being done radical operation and is expanding radical operation, and this also means that many breast carcinoma female patients will face the result of losing breast bitterly after surgery by operative treatment.And as radiotherapy and the chemotherapy of primary disease primary treatment method, when killing cancerous cell, greatly destroyed especially the immune system of human body, and to patient, bring great misery, cause the reduction greatly of patient's body constitution, affect quality of life.
After breast carcinoma Chinese traditional treatment adds, increasing patient starts seem concern especially of to breast carcinoma Chinese traditional treatment.The traditional Chinese medical science thinks that tumor is that the evil sun of containing presses down, mechanism of qi can not be adjusted and reach knot blood clotting one-tenth of a specified duration silt, and raw caking, the direction that principal and subordinate consolidates evil removing, softening the hard mass joint, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgesic adhesive is started with tumor is cleared up, softening hard lump, invigorates blood circulation with the moral of qualcomm meridian, and blood stasis dispelling is to clear up congestion and lump, the increase of inhibition tumor cell, prevention of recurrence shifts; By corresponding meridian point external application, ingredient Transdermal absorption, through focus, can effectively alleviate with alleviating pain, cough, suppress breathe heavily, the symptom such as ascites, alleviate patient's misery, a lot of cancer patients are all cured, and have the incomparable advantage of doctor trained in Western medicine.
But because primary disease pathogenic factor is not clear, and patient individual difference is larger, there is no one group of desirable prescription for Most patients general character.Mostly existing prescription is the set of numerous conventional prescriptions, although all play certain therapeutical effect for different patients, has certain toxic and side effects, is not suitable for life-time service, and therapeutic effect is not good.
Summary of the invention
Problem to be solved by this invention is to provide a kind of to medicative Chinese medicine preparation of breast carcinoma and preparation method thereof.
In order to solve the problems of the technologies described above, the Chinese medicine preparation for the treatment of breast carcinoma of the present invention, its effective ingredient includes the raw material of following weight portion and makes: Nidus Vespae 85～95, Squama Manis 85～95, Herba Salviae Chinensis 145～155, Semen Vaccariae 145～155, Radix Angelicae Sinensis 145～155, the Radix Astragali 145～155, Rhizoma Curcumae 145～155, Poria 145～155, Radix Notoginseng powder 25～35.
Nidus Vespae is " with tree, above hang and to obtain wind dew person, its honeybee yellow black, is permitted for long cun, and under non-other room, slight Nidus Vespae also " in < < Tang materia medica > >.Pharmacology: antiinflammatory action: Nidus Vespae aqueous extract every day 2 times, each gavage 30g/kg, the mice auricle swelling that Oleum Tiglii is brought out has obvious inhibitory action, and after mice is extractd adrenal gland, its antiinflammatory action still exists; These product of rat skin lower injection 5g/kg, all has to the footpad swelling due to Ovum Gallus domesticus album, the granulation tissue hyperplasia that cotton balls brings out the inhibitory action showing.Pharmacology in the traditional Chinese medical science: control all evil cellulitis, attached bone carbuncle, root is at internal organs, and severe and migratory arthralgia swells out, treats the swollen all poison of superficial obstructive phlebitis, and tumor is had to obvious therapeutic effect.
Squama Manis saline taste is cool, enters Liver Channel stomach warp, the routed carbuncle of detumescence, and Shufeng Huoluo, controls carbuncle skin ulcer swollen, dispelling the stagnated QI promoting the circulation of blood, antipyretic relieving internal heat, the routed carbuncle of detumescence, arranges dense blood.Gas raw meat and altering, very careful, therefore can declare logical internal organs, implement meridians, thoroughly reach pass key, all blood clotting blood gathers for disease, all can open it.
Herba Salviae Chinensis is flat, enters Liver Channel, has the effect of blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Be mainly used to clinically treat each species specificity and nonspecific infection, as lymphoid tuberculosis, hepatitis and mastitis, too fat to move sore etc., reduced the possibility shifting.
Semen Vaccariae has promoting the circulation of blood to stimulate the menstrual flow, and expedites the emergence of stimulating milk secretion, the effect of detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle.
Nidus Vespae in we, Squama Manis, Herba Salviae Chinensis, the common strengthening the body resistance of Semen Vaccariae, sending up the lucid YANG, removing silt heresy are main, Ruzhong addiction core disappears, the airsetting blood of harmonizing the liver and spleen two warps, depressed liver-energy dispersing and QI regulating, eliminating stagnation be except becoming silted up, blood vessels in like manner, antipyretic relieving internal heat, hard long-pending carbuncle disappears, evacuation of pus blood, conditioning viscera, homophony enters for monarch drug.Assistant is with Radix Angelicae Sinensis and the Radix Notoginseng powder dredging the meridian of enriching blood, Radix Astragali tonifying QI to promote blood circulation, and Poria invigorating spleen to remove dampness helps drug absorption, Rhizoma Curcumae removing blood stasis promoting the circulation of QI to relieve pain, long-pending eliminating stagnation, removing blood stasis, promoting the circulation of QI to relieve pain.The technical program eliminating stagnation on the basis that increases immunity of organisms, except becoming silted up, is eliminated tumor.We can also be used for the treatment of cyclomastopathy.
In order to solve the problems of the technologies described above, the present invention treats the preparation method of the Chinese medicine preparation of breast carcinoma, comprise the steps: A, will after described raw material pulverizing, be mixed to form mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extract volatile oil, medicinal residues are standby; B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions; C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
The patient who is greater than 3 centimetres for cancerous protuberance diameter, in technique scheme, more specifically technical scheme is: comprise the steps: A, described raw material is added to the decocting of the Fructus Polygoni Orientalis of 145～155 weight portions and the Semen Persicae of 85～95 weight portions and 145～155 weight portions crosses the Rhizoma Amorphophalli of 1.5 hours, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extracts volatile oil, and medicinal residues are standby; B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions; C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
The patient who is greater than 3 centimetres for cancerous protuberance diameter, selects except the stronger Fructus Polygoni Orientalis of swollen effect that becomes silted up, and is equipped with Semen Persicae and Rhizoma Amorphophalli.Fructus Polygoni Orientalis breaks pharmacology: antitumor action: get mice gavage every day water Polygonum (being Fructus Polygoni Orientalis) decoct, tincture or ligroin extraction, continuous 10 days, ehrlich carcinoma (ascitic type and solid type) and S-180 are had to certain inhibitory action; Bacteriostasis: Herba Polygoni Orientalis fruit (being Fructus Polygoni Orientalis) water decoction all has bacteriostasis by the method for burrowing to dysentery bacterium and shigella flexneri, and antibacterial circle diameter is respectively 17mm and 13mm.With trench method, the inhibition distance of dysentery bacterium and shigella flexneri is respectively to 16mm and 7mm.The concentration of water decoction is 1:1.Herba Polygoni Orientalis edema of the legs during pregnancy fragrance is salty, and under can softening the hard mass rushing down, wearing Squama Manis can promoting blood circulation to restore menstrual flow; Can control blood stasis mass in the abdomen, lumps in the chest and abdomen.Semen Persicae blood stasis removing and clots absorbing, treatment swelling and pain due to blood stasis, Semen Persicae alcohol extract has anticoagulant effect and weak haemolysis, reduces patient's high blood clotting symptom, improves body immunity.Rhizoma Amorphophalli, having another name called Rhizoma amorphophalli is Araeceae Amorphophallus, the tuber of herbaceos perennial, for treating one of special medicinal material of tumor.
For ulcerogenic patient, in technique scheme, more specifically technical scheme can also be: comprise the steps: A, described raw material is added to the Radix Pseudostellariae of 295～305 weight portions and the Rhizoma Smilacis Glabrae of 295～305 weight portions, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extracts volatile oil, and medicinal residues are standby; B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions; C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
For ulcerogenic patient, select Radix Pseudostellariae lift to fall into yang invigorating, the cold-evil that Rhizoma Smilacis Glabrae is opened loose taste falls and lets out.Radix Pseudostellariae, qi-restoratives medicine, Qi-tonifying drug, enters the heart, spleen, lung three warps, cures mainly benefit strengthening spleen and lung, and supplementing QI for promoting the production of body fluid, controls cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema, quenches one's thirst, and spirit is tired; For deficiency-weakness of spleen-QI, deficiency of stomach-Yin, lack of appetite body is tired, thirsty dry tongue; Deficiency of the lung cough caused by dryness, dry pharynx expectorant is sticky; Deficiency of both vital energy and Yin, palpitation and insomnia.Rhizoma Smilacis Glabrae, nature and flavor are sweet, light, flat, enter liver, spleen, stomach warp, open loose.
Patient for inclined to one side deficiency of YIN body constitution, in technique scheme, more specifically technical scheme can also be: comprise the steps: A, described raw material is added to the Radix Asparagi of 145～155 weight portions and the pulverizing of the Radix Rehmanniae of 145～155 weight portions, the Radix Trichosanthis that adds 145～155 weight portions fully mixes rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extracts volatile oil, and medicinal residues are standby; B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions; C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
The patient of deficiency of YIN body constitution, selects Radix Asparagi YIN nourishing and the production of body fluid promoting partially, and lung moistening clears away heart-fire.Radix Asparagi, sweet, bitter, cold, enter lung, heart channel, for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, diphtheria.The Radix Rehmanniae, clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis, for calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.Radix Trichosanthis is clearing away heat-fire class medicine, and its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence, for control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.Its deficiency of YIN-blood is mended in the common YIN nourishing of Radix Asparagi, the Radix Rehmanniae and Radix Trichosanthis, pathogenic fire reducing, YANG hyperactivity suppressing, the aquatic Tianjin of clearing heat in the lungization, nourishing kidney, and energy enhancing body defending and fighting against diseases and adaptive capacity, promote the propagation of marrow hemopoietic stem cells etc., be that the body resistance strengthening and constitution consolidating is eliminating evil altogether, conditioning viscera function, improve body immunity, eliminate focus and conditioning and recover parallel.
Patient for partially cold body constitution, in technique scheme, more specifically technical scheme can also be: comprise the steps: A, described raw material is added to the Ramulus Cinnamomi of 25～35 weight portions and the Herba Asari of 25～35 weight portions, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extracts volatile oil, and medicinal residues are standby; B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions; C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
The patient of partially cold body constitution, selects Ramulus Cinnamomi to join Herba Asari.Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Herba Asari dispels the wind, cold expelling, and row water, has one's ideas straightened out, dispersing wind-cold, antalgic, warming for resolving cold-phlegm, controls air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.
Patient for partial heat body constitution, in technique scheme, more specifically technical scheme can also be: comprise the steps: A, described raw material added to the Flos Lonicerae of the Spica Prunellae of 145～155 weight portions and the Herba Taraxaci of 295～305 weight portions and 295～305 weight portions, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extracts volatile oil, and medicinal residues are standby; B. the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions; C. the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
The patient of partial heat body constitution, selects the exterior heat of the clear interior-heat solution of Herba Taraxaci Spica Prunellae Flos Lonicerae.Herba Taraxaci heat-clearing and toxic substances removing: can be used for pyretic toxicity card, especially kind removing heat from the liver, treatment liver-heat conjunctival congestion and swelling pain, and multi-infection, purulent disease; Eliminating carbuncle eliminating stagnation: treatment pyretic toxicity is stopped up the carbuncle sore tumefacting virus tie due to the muscle, hyperpyrexia.Herba Taraxaci has good effect to acute mastitis, energy detoxicating and resolving stagnation of pathogens lactogenesis, and oral administration or external application, often join Flos Lonicerae and be equal to use.Spica Prunellae is cold in nature, sweet in the mouth, pungent, micro-hardship, there is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, be applicable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.Modern pharmacological research shows, Spica Prunellae has the effect reducing blood pressure, and can blood vessel dilating, and its contained rutin has antiinflammatory action, and can reduce vascular permeability, reduces fragility, reduces liver fat.Spica Prunellae resists the effect of cancerous cell in addition.
Patient for inclined to one side yang deficiency body constitution, in technique scheme, more specifically technical scheme can also be: comprise the steps: A, will after described raw material pulverizing, be mixed to form mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extract volatile oil, medicinal residues are standby; B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, then add by the Ginseng Bolus for Tonification of 85～95 parts of described parts by weight of raw materials, fully dissolve, at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions; C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
Ginseng Bolus for Tonification in technical scheme comprises 100 grams of Radix Ginsengs, 100 grams of the Rhizoma Atractylodis Macrocephalaes of parching with earth, 75 grams, Poria, 100 grams, the Radix Glycyrrhizae of processed with honey, 100 grams of Radix Angelicae Sinensis, 75 grams of Radix Rehmanniae Preparata, 100 grams of the Radix Paeoniae Albas of parched with bran, 100 grams of the Radixs Astragali of processed with honey, 100 grams of Pericarpium Citri Reticulataes, 50 grams of Radix Polygalae (processed), 100 grams of Cortex Cinnamomis, 75 grams of the Fructus Schisandrae Chinensis that wine steams, are ground into fine powder, sieve, mix.Separately get 50 grams, Rhizoma Zingiberis Recens, 100 grams, Fructus Jujubae, gradation decoct with water to taste to the greatest extent, filter, at the temperature of 80 ℃ filtrate to be concentrated into relative density be 1.25.Every 100 grams of powder add 35～50 grams of refined honeys and Rhizoma Zingiberis Recens, Fructus Jujubae liquid, and general ball is dry, makes water-honeyed pill; Or add 90～100 grams of refined honeys and mix thoroughly with Rhizoma Zingiberis Recens, Fructus Jujubae liquid, the honeyed pill of making.Ginseng Bolus for Tonification's temperature compensation QI and blood.For deficiency of both the heart and spleen, deficiency of both QI and blood, the thin Mental fatigue of shape, anorexia and loose stool is weak after being ill.
In above technical scheme, the preparation method of the Chinese medicine preparation of this treatment breast carcinoma more specifically technical scheme can also be: at step C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed; Increase afterwards step D: add 0.1% leaven of liquid gross mass after mixing, ° C temperature bottom fermentation is 28 days 25 ° of C～30, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.The Chinese medicine preparation of this treatment breast carcinoma, can also be for the leaven of again producing except being used for the treatment of breast carcinoma.In this programme, increased the fermentation of 28 days, made drug molecule be degraded into micromolecule, activity has increased several times, and is more conducive to absorption of human body.Ferment in addition 28 days, both reduced the fire-toxin decocting, can make again the normal arsenite occurring of fermentation initial stage completely decompose and disappear after 25 days in fermentation, other antibacterials except yeast are all dead because of anaerobic, reduced the link of sterilizing.
The Chinese medicine preparation of the treatment breast carcinoma of technique scheme, the dosage form of described preparation is pill or capsule.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Embodiment mono-:
The Chinese medicine preparation of this treatment breast carcinoma, its effective ingredient includes the raw material of following weight portion and makes: 85 parts of Nidus Vespaes, 95 parts of Squama Maniss, 145 parts of Herba Salviae Chinensiss, 155 parts of Semen Vaccariae, 145 parts of Radix Angelicae Sinensis, 155 parts of the Radixs Astragali, 145 parts of Rhizoma Curcumae, 155 parts of Poria, 30 parts of Radix Notoginseng powder.This Chinese medicine preparation is liquor, for oral administration.In other embodiments, can also be pill or capsule, for oral administration.
Embodiment bis-:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 95 parts of Nidus Vespaes, 85 parts of Squama Maniss, 155 parts of Herba Salviae Chinensiss, 145 parts of Semen Vaccariae, 155 parts of Radix Angelicae Sinensis, 145 parts of the Radixs Astragali, 155 parts of Rhizoma Curcumae, 145 parts of Poria, 35 parts of Radix Notoginseng powder, are mixed to form mixture after pulverizing, first use described in cold water soak mixture after 30 minutes, steam distillation 6 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.6 hours, 1.3 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, at 40 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
Embodiment tri-:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 85 parts of Nidus Vespaes, 95 parts of Squama Maniss, 145 parts of Herba Salviae Chinensiss, 155 parts of Semen Vaccariae, 145 parts of Radix Angelicae Sinensis, 155 parts of the Radixs Astragali, 145 parts of Rhizoma Curcumae, 155 parts of Poria, 25 parts of Radix Notoginseng powder, are mixed to form mixture after pulverizing, first use described in cold water soak mixture after 40 minutes, steam distillation 7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 4 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.8 hours, 1.5 hour, 1.3 hours, the decocting liquid of collecting for three times is merged, at 40 ° of C temperature, being concentrated into relative density is 1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed;
D, add 0.1% leaven of liquid gross mass after mixing, 25 ° of C～30, ° C temperature bottom fermentation is 28 days, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.Leaven is yeast, and while again preparing, leaven is preferentially selected the Chinese medicine preparation that the present embodiment is prepared.
Embodiment tetra-:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 90 parts of Nidus Vespaes, 90 parts of Squama Maniss, 150 parts of Herba Salviae Chinensiss, 150 parts of Semen Vaccariae, 150 parts of Radix Angelicae Sinensis, 150 parts of the Radixs Astragali, 150 parts of Rhizoma Curcumae, 150 parts of Poria, 25 parts of Radix Notoginseng powder, 145 parts of Fructus Polygoni Orientaliss, 155 parts of the Rhizoma Amorphophalli that 95 parts, Semen Persicae and decocting are spent 1.5 hours, are pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 40 minutes, steam distillation 7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 4 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.8 hours, 1.5 hour, 1.3 hours, the decocting liquid of collecting for three times is merged, at 50 ℃ of temperature, being concentrated into relative density is 1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, described preparation is liquor for oral administration, we are applicable to the patient that cancerous protuberance diameter is greater than 3 centimetres, 250 milliliters of every days, take at twice.
Embodiment five:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 90 parts of Nidus Vespaes, 90 parts of Squama Maniss, 150 parts of Herba Salviae Chinensiss, 150 parts of Semen Vaccariae, 150 parts of Radix Angelicae Sinensis, 150 parts of the Radixs Astragali, 150 parts of Rhizoma Curcumae, 150 parts of Poria, 25 parts of Radix Notoginseng powder, 155 parts of Fructus Polygoni Orientaliss, 145 parts of the Rhizoma Amorphophalli that 85 parts, Semen Persicae and decocting are spent 1.5 hours, are pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes, steam distillation 7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 4 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.6 hours, 1.3 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, at 40 ℃ of temperature, being concentrated into relative density is 1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed;
D, add 0.1% leaven of liquid gross mass after mixing, 25 ° of C～30, ° C temperature bottom fermentation is 28 days, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.Leaven is yeast, and while again preparing, leaven is preferentially selected the Chinese medicine preparation that the present embodiment is prepared.We are applicable to the patient that cancerous protuberance diameter is greater than 3 centimetres, 250 milliliters of every days, take at twice.
Embodiment six:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 90 parts of Nidus Vespaes, 90 parts of Squama Maniss, 150 parts of Herba Salviae Chinensiss, 150 parts of Semen Vaccariae, 150 parts of Radix Angelicae Sinensis, 150 parts of the Radixs Astragali, 150 parts of Rhizoma Curcumae, 150 parts of Poria, 25 parts of Radix Notoginseng powder, 305 parts of 305 parts of Radix Pseudostellariaes and Rhizoma Smilacis Glabraes, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 35 minutes, steam distillation 6.5 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3.5 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.7 hours, 1.4 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, at 45 ° of C temperature, being concentrated into relative density is 1.55 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration, and we are applicable to ulcerogenic patient, 250 milliliters of every days, take at twice.
Embodiment seven:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 90 parts of Nidus Vespaes, 90 parts of Squama Maniss, 150 parts of Herba Salviae Chinensiss, 150 parts of Semen Vaccariae, 150 parts of Radix Angelicae Sinensis, 150 parts of the Radixs Astragali, 150 parts of Rhizoma Curcumae, 150 parts of Poria, 25 parts of Radix Notoginseng powder, 295 parts of 295 parts of Radix Pseudostellariaes and Rhizoma Smilacis Glabraes, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 40 minutes, steam distillation 7 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3.5 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.7 hours, 1.4 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, at 40 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed;
D, add 0.1% leaven of liquid gross mass after mixing, 25 ° of C～30, ° C temperature bottom fermentation is 28 days, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.Leaven is yeast, and while again preparing, leaven is preferentially selected the Chinese medicine preparation that the present embodiment is prepared.We are applicable to ulcerogenic patient, 250 milliliters of every days, take at twice.
Embodiment eight:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 90 parts of Nidus Vespaes, 90 parts of Squama Maniss, 150 parts of Herba Salviae Chinensiss, 150 parts of Semen Vaccariae, 150 parts of Radix Angelicae Sinensis, 150 parts of the Radixs Astragali, 150 parts of Rhizoma Curcumae, 150 parts of Poria, 25 parts of Radix Notoginseng powder, 155 parts, 145 parts of Radix Asparagi and the Radix Rehmanniae, pulverize, and adds after 145 parts of Radix Trichosanthis fully mix and form mixture, first use described in cold water soak mixture after 30 minutes, steam distillation 6 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.6 hours, 1.3 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, at 40 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration, and we are applicable to the patient of inclined to one side deficiency of YIN body constitution, 250 milliliters of every days, take at twice.
Embodiment nine:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 85 parts of Nidus Vespaes, 95 parts of Squama Maniss, 145 parts of Herba Salviae Chinensiss, 155 parts of Semen Vaccariae, 145 parts of Radix Angelicae Sinensis, 155 parts of the Radixs Astragali, 145 parts of Rhizoma Curcumae, 155 parts of Poria, 35 parts of Radix Notoginseng powder, 145 parts, 155 parts of Radix Asparagi and the Radix Rehmanniae, pulverize, and adds after 155 parts of Radix Trichosanthis fully mix and form mixture, first use described in cold water soak mixture after 40 minutes, steam distillation 7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 4 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.8 hours, 1.5 hour, 1.3 hours, the decocting liquid of collecting for three times is merged, at 50 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed;
D, add 0.1% leaven of liquid gross mass after mixing, 25 ° of C～30, ° C temperature bottom fermentation is 28 days, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.Leaven is yeast, and while again preparing, leaven is preferentially selected the Chinese medicine preparation that the present embodiment is prepared.We are applicable to the patient of inclined to one side deficiency of YIN body constitution, 250 milliliters of every days, take at twice.
Embodiment ten:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 95 parts of Nidus Vespaes, 85 parts of Squama Maniss, 155 parts of Herba Salviae Chinensiss, 145 parts of Semen Vaccariae, 155 parts of Radix Angelicae Sinensis, 145 parts of the Radixs Astragali, 155 parts of Rhizoma Curcumae, 145 parts of Poria, 30 parts of Radix Notoginseng powder, 25 parts of 25 parts of Ramulus Cinnamomi and Herba Asaris, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 40 minutes, steam distillation 7 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 4 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.8 hours, 1.5 hour, 1.3 hours, the decocting liquid of collecting for three times is merged, at 50 ℃ of temperature, being concentrated into relative density is 1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration, and we be applicable to partially the to tremble with fear patient of body constitution, 250 milliliters of every days, takes at twice.
Embodiment 11:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 85 parts of Nidus Vespaes, 95 parts of Squama Maniss, 145 parts of Herba Salviae Chinensiss, 155 parts of Semen Vaccariae, 145 parts of Radix Angelicae Sinensis, 155 parts of the Radixs Astragali, 145 parts of Rhizoma Curcumae, 155 parts of Poria, 35 parts of Radix Notoginseng powder, 35 parts of 35 parts of Ramulus Cinnamomi and Herba Asaris, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes, steam distillation 6 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.7 hours, 1.4 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, at 40 ℃ of temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed;
D, add 0.1% leaven of liquid gross mass after mixing, 25 ° of C～30, ° C temperature bottom fermentation is 28 days, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.Leaven is yeast, and while again preparing, leaven is preferentially selected the Chinese medicine preparation that the present embodiment is prepared.We be applicable to partially the to tremble with fear patient of body constitution, 250 milliliters of every days, takes at twice.
Embodiment 12:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 85 parts of Nidus Vespaes, 95 parts of Squama Maniss, 145 parts of Herba Salviae Chinensiss, 155 parts of Semen Vaccariae, 145 parts of Radix Angelicae Sinensis, 155 parts of the Radixs Astragali, 145 parts of Rhizoma Curcumae, 155 parts of Poria, 35 parts of Radix Notoginseng powder, 145 parts of Spica Prunellaes, 305 parts of 295 parts of Herba Taraxacis and Flos Loniceraes, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes, steam distillation 6.5 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3.5 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.6 hours, 1.3 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, at 40 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration, and we are applicable to the patient of partial heat body constitution, 250 milliliters of every days, take at twice.
Embodiment 13:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 95 parts of Nidus Vespaes, 85 parts of Squama Maniss, 155 parts of Herba Salviae Chinensiss, 155 parts of Semen Vaccariae, 145 parts of Radix Angelicae Sinensis, 145 parts of the Radixs Astragali, 155 parts of Rhizoma Curcumae, 145 parts of Poria, 25 parts of Radix Notoginseng powder, 155 parts of Spica Prunellaes, 295 parts of Herba Taraxaci part 305 and Flos Loniceraes, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 40 minutes, steam distillation 7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 4 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.7 hours, 1.4 hour, 1.3 hours, the decocting liquid of collecting for three times is merged, at 40 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed;
D, add 0.1% leaven of liquid gross mass after mixing, 25 ° of C～30, ° C temperature bottom fermentation is 28 days, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.Leaven is yeast, and while again preparing, leaven is preferentially selected the Chinese medicine preparation that the present embodiment is prepared.We are applicable to the patient of partial heat body constitution, 250 milliliters of every days, take at twice.
Embodiment 14:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 95 parts of Nidus Vespaes, 85 parts of Squama Maniss, 155 parts of Herba Salviae Chinensiss, 155 parts of Semen Vaccariae, 145 parts of Radix Angelicae Sinensis, 145 parts of the Radixs Astragali, 155 parts of Rhizoma Curcumae, 145 parts of Poria, 25 parts of Radix Notoginseng powder, are mixed to form mixture after pulverizing, first use described in cold water soak mixture after 30 minutes, steam distillation 6 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.6 hours, 1.3 hour, 1.2 hours, the decocting liquid of collecting for three times is merged, then add the Ginseng Bolus for Tonification by 85 parts of above-mentioned medical material weight portion, fully dissolve, at 40 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration, and we are applicable to the patient of inclined to one side yang deficiency body constitution, 250 milliliters of every days, take at twice.
Embodiment 15:
The preparation method of the Chinese medicine preparation of this treatment breast carcinoma, comprises the steps:
A, by the component of following weight portion: 85 parts of Nidus Vespaes, 95 parts of Squama Maniss, 145 parts of Herba Salviae Chinensiss, 145 parts of Semen Vaccariae, 155 parts of Radix Angelicae Sinensis, 155 parts of the Radixs Astragali, 145 parts of Rhizoma Curcumae, 155 parts of Poria, 35 parts of Radix Notoginseng powder, are mixed to form mixture after pulverizing, first use described in cold water soak mixture after 40 minutes, steam distillation 7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 4 times of medical material gross weight, decoct three times, three times decocting time is followed successively by 1.8 hours, 1.5 hour, 1.3 hours, the decocting liquid of collecting for three times is merged, then add the Ginseng Bolus for Tonification by 95 parts of above-mentioned medical material weight portion, fully dissolve, at 40 ° of C temperature, being concentrated into relative density is 1.5 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed;
D, add 0.1% leaven of liquid gross mass after mixing, 25 ° of C～30, ° C temperature bottom fermentation is 28 days, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.Leaven is yeast, and while again preparing, leaven is preferentially selected the Chinese medicine preparation that the present embodiment is prepared.We are applicable to the patient of inclined to one side yang deficiency body constitution, 250 milliliters of every days, take at twice.
The clinical observation on the therapeutic effect of embodiment tetra-to embodiment 15.
Case-data: all cases all passes through pathology and image analysis, be diagnosed as primary breast cancer middle and advanced stage patient 60 examples, be divided into two groups, treatment group 30 examples, by nonoperative suit the medicine to the illness and the basis of nutritional support treatment on, the liquid traditional Chinese medicine that gives embodiment tetra-to embodiment 15 is for oral administration, 250 milliliters of every days, every day 2 times; Matched group 30 examples, to doctor trained in Western medicine operation and radiochemistry treatment.5 years time limits for the treatment of, 5 years observation periods.
Two groups of patients are women, and the age, primary tumor was partly the left and right sides all between 30 to 60 years old, treatment group and matched group contrast, difference not statistically significant (P > 0.05).
Pathological classification comparison: IDC 22 examples in treatment group 30 examples, ILC 8 examples; IDC 21 examples in treatment group 30 examples, ILC 9 examples, with matched group contrast, P > 0.05.
Pathological staging comparison: II phases 11 example in treatment group 30 examples, III phases 14 example, IV phases 5 example; II phases 11 example in contrast groups 30 examples, III phases 13 example, IV phases 6 example, with matched group contrast, P > 0.05.
Treatment standard:
Safety indexes: hematuria, stool routine inspection and electrocardiogram, hepatic and renal function inspection; Press the acute and subacute toxicity reaction normal comparison of WTO tumor medicine, wherein acute the and subacute toxicity reaction normal of WTO tumor medicine is divided into: 0 degree, I degree, II degree, III degree, be designated as respectively 0 minute, 1 minute, 2 minutes, 3 minutes, 4 minutes.
Focus situation after treatment: be divided into and alleviate (CR), partial rcsponse (PR), unchanged (NC), deterioration (PD), coefficient of stabilization=[(CR+ PR+ NC)+(CR+ PR+ NC+PD)] * 100% completely by the objective treatment standard of the tumor of WTO system.
Life quality scoring situation: according to Ka Shi scoring (Karmofsky) standard, after treatment, scoring is than increasing by 10 minutes persons of > before treating for improving, scoring increases or scoring reduces by≤10 minutes persons for stable, and scoring reduces 10 minutes persons of > for declining.Body weight curative effect scoring: it is effective treating >=1.5 kilograms of front body weight increases after treatment; It is effective after treatment, treating >=1.0 kilograms of front body weight increases; It is invalid after treatment, treating 1.0 kilograms of front body weight increase less thaies.
Table 1: two groups of safety comparisons (example)
Table 2: after two groups of treatments, focus situation changes relatively
Table 3: after two groups of treatments, life quality scoring relatively
Conclusion: according to table 1 liang group untoward reaction after 5 years, through Wilconxon rank test, leukopenia, anemia, thrombocytopenia, transaminase's rising, nausea and vomiting, diarrhoea etc. are not statistically significant (P > 0.05) all.Show that Chinese medicine compound is safe, untoward reaction is few, can long-term taking.After changing comparison and table 3 liang group treatment according to focus situation after table 2 liang group treatment, life quality scoring relatively, reach a conclusion: by nonoperative suit the medicine to the illness and the basis of nutritional support treatment on, the liquid traditional Chinese medicine that gives embodiment tetra-to embodiment 15 is for oral administration, there is obvious therapeutic effect, the patient who has 1 routine cancerous protuberance diameter to be greater than 3 centimetres in matched group does bilateral resection operation, in the partially cold patient of body constitution and the patient of partial heat body constitution, all does bilateral resection operation.Use this preparation, in whole 30 routine cases, all without excision in the situation that, anaphase effect is obviously better than matched group.
Claims (10)
1. a Chinese medicine preparation for the treatment of breast carcinoma, the effective ingredient that it is characterized in that it includes the raw material of following weight portion and makes: Nidus Vespae 85～95, Squama Manis 85～95, Herba Salviae Chinensis 145～155, Semen Vaccariae 145～155, Radix Angelicae Sinensis 145～155, the Radix Astragali 145～155, Rhizoma Curcumae 145～155, Poria 145～155, Radix Notoginseng powder 25～35.
2. according to the preparation method of the Chinese medicine preparation of the treatment breast carcinoma described in claim 1 any one, it is characterized in that: comprise the steps:
A, will after described raw material pulverizing, be mixed to form mixture, first use that mixture is after 30 minutes～40 minutes described in cold water soak, steam distillation 6 hours～7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
3. the preparation method of the Chinese medicine preparation for the treatment of breast carcinoma according to claim 1, is characterized in that: comprise the steps:
A, described raw material is added to the decocting of the Fructus Polygoni Orientalis of 145～155 weight portions and the Semen Persicae of 85～95 weight portions and 145～155 weight portions crosses the Rhizoma Amorphophalli of 1.5 hours, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
4. the preparation method of the Chinese medicine preparation for the treatment of breast carcinoma according to claim 1, is characterized in that: comprise the steps:
A, described raw material is added to the Radix Pseudostellariae of 295～305 weight portions and the Rhizoma Smilacis Glabrae of 295～305 weight portions, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
5. the preparation method of the Chinese medicine preparation for the treatment of breast carcinoma according to claim 1, is characterized in that: comprise the steps:
A, described raw material is added to the Radix Asparagi of 145～155 weight portions and the Radix Rehmanniae of 145～155 weight portions pulverizes, the Radix Trichosanthis that adds 145～155 weight portions fully mixes rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
6. the preparation method of the Chinese medicine preparation for the treatment of breast carcinoma according to claim 1, is characterized in that: comprise the steps:
A, described raw material is added to the Ramulus Cinnamomi of 25～35 weight portions and the Herba Asari of 25～35 weight portions, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
7. the preparation method of the Chinese medicine preparation for the treatment of breast carcinoma according to claim 1, is characterized in that: comprise the steps:
A, described raw material is added to the Flos Lonicerae of the Spica Prunellae of 145～155 weight portions and the Herba Taraxaci of 295～305 weight portions and 295～305 weight portions, be pulverized and mixed rear formation mixture, first use described in cold water soak mixture after 30 minutes～40 minutes, steam distillation 6 hours～7 hours, extract volatile oil, medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, and at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
8. the preparation method of the Chinese medicine preparation for the treatment of breast carcinoma according to claim 1, is characterized in that: comprise the steps:
A, will after described raw material pulverizing, be mixed to form mixture, first use that mixture is after 30 minutes～40 minutes described in cold water soak, steam distillation 6 hours～7 hours, extracts volatile oil, and medicinal residues are standby;
B, the resulting described medicinal residues of steps A are boiled with the decocting of 3～4 times of medical material gross weight, decoct three times, three decocting times are followed successively by 1.6 hours～and 1.8 hours, 1.3 hours～1.5 hours, 1.2 hours～1.3 hours, the decocting liquid of collecting for three times is merged, then add by the Ginseng Bolus for Tonification of 85～95 parts of described parts by weight of raw materials, fully dissolve, at 40 ° of C～50 ℃ temperature, being concentrated into relative density is 1.5～1.6 concentrated solutions;
C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed, subpackage, obtains the Chinese medicine preparation of this treatment breast carcinoma, and described preparation is liquor for oral administration.
9. according to the preparation method of the Chinese medicine preparation of the treatment breast carcinoma described in claim 2 to 8 any one, it is characterized in that: at step C, the described volatile oil of the concentrated solution of step B gained and steps A gained is mixed; Increase afterwards step D: add 0.1% leaven of liquid gross mass after mixing, ° C temperature bottom fermentation is 28 days 25 ° of C～30, obtains the Chinese medicine preparation of this treatment breast carcinoma after subpackage, and described preparation is liquor for oral administration.
10. the Chinese medicine preparation for the treatment of breast carcinoma according to claim 1, is characterized in that: the dosage form of described preparation is pill or capsule.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104721784A (en) * | 2015-03-09 | 2015-06-24 | 王艳君 | Blood circulation-activating and stasis-removing preparation for breast tumour and preparation method |
| CN104758507A (en) * | 2015-04-16 | 2015-07-08 | 张录云 | Medicine for treating breast hyperplastic nodule |
| US10265369B2 (en) | 2015-05-11 | 2019-04-23 | Jian Ma | Topical drug for treating breast cancer and preparation method thereof |
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