CN105056160A

CN105056160A - Medicine composition for treating agalactia of cows and preparation method thereof

Info

Publication number: CN105056160A
Application number: CN201510616083.1A
Authority: CN
Inventors: 黄河; 李鑫
Original assignee: Shandong New Hope Liuhe Group Co Ltd
Current assignee: Shandong New Hope Liuhe Group Co Ltd
Priority date: 2015-09-25
Filing date: 2015-09-25
Publication date: 2015-11-18

Abstract

The invention discloses a medicine composition for treating agalactia of cows and a preparation method thereof. The medicine composition comprises the following raw medicinal materials: radix astragali, largehead atractylodes rhizome, rhizome of conic gymnadenia, root or all-grass of Aleppo avens, dried tangerine peel, manyprickle acathopanax root, lucid ganoderma, gynostemma pentaphyllum, fruit of caraway, Chinese date, heterophylly falsestarwort root, root of foldleaf daylily, hedge prinsepia nut, herb of Siberian sealavender, rhizoma dioscoreae, testes and penis of harbour seal, herb of common canscora, rhizome of largeleaf Japanese ginseng, root of tungoiltree, zedoray rhizome, seed of dish mustard, large blister beetle, all-grass of hirsute gonostegia and argent bluebellflower. The medicine composition has the beneficial effects that the medicine composition has the functions of tonifying the spleen and regulating qi and replenishing qi and nourishing blood, can also achieve the effects of promoting plumpness of breasts, normal development of nipples and fullness of milk, improving the immunities of cows and well ensuring normal growth of mammary glands and other body organs of the cows and has the advantages of high cure rate, quick effect, short course of treatment, no toxic or side effect, and the like.

Description

A kind ofly treat pharmaceutical composition of milch cow hypogalactia and preparation method thereof

Technical field

The present invention relates to field of veterinary, particularly a kind ofly treat pharmaceutical composition of milch cow hypogalactia and preparation method thereof.

Background technology

Cattle farm often occur young cattle arrive mating age still non-estrus, become milch cow long-term non-estrus in puerperal, the phenomenon such as output falls sharply, therefore some cattle eliminates and causes no small loss.Female animal is young, development of breast imperfection and lack milk.Show as breast tightly little, nipple cripetura, outward appearance is inmature, agalactosis, refusal suckling.Cow hypogalactia after delivery is due to nutritional disorder, the thin deficiency of vital energy of body, or body to strengthen waist good, or puerperal half empty half heat, or the common disease that many reasons causes after the recovery from illness of puerperal infection disease etc.

The main cause of general cow hypogalactia after delivery has: 1. feeding and management is not good at or the rotten feedstuff that goes rotten of feeding causes milch cow to become thin; 2. severe cold or hot overstimulation; 3. mammary gland dysplasia or body of gland disorder; 4. old or excessive forced labour, causes mammary gland hypofunction or stopping; 5. earlier mating premature labor, puerperal fever or mastitis; 6. galactopoiesis milch cow duration drylot feeding material causes hypomotility or Other diseases etc.Be subject to the impact of certain factor during breast and cause mammary gland disorder, causing lactation amount to reduce or agalactia.Be mainly in malnutrition, old-age group and first milking cow clinically.The cause of disease: malnutrition is the main cause causing milch cow hypogalactia.As hot summer high temperature season milch cow appetite die-offs or do not eat, Winter-Spring milch cow latter half of gestation drylot feeding lacks greenfeed and high-quality Radix Glycyrrhizae, concentrate undersupply etc. all can cause cow hypogalactia after delivery.

At present, western medical treatment milch cow hypogalactia widely applies antibiotic, the chemical synthetic drugs such as Pituamin.Western medicine is for motherland's Chinese medicine, and the medicine that doctor trained in Western medicine is used, generally makes with chemical synthesis process or obtain through refining from natural product and form.The course for the treatment of is longer, and drug residue is comparatively large, and effect is undesirable, has impact to a certain degree to the health of milch cow and consumer.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition for the treatment of milch cow hypogalactia, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, pharmaceutical composition of the present invention has spleen invigorating and regulates the flow of vital energy, effect of benefiting qi and nourishing blood, full and the nipple normal development of breast can also be promoted, milk is full, improve the immunity of milch cow, but also can be good at the normal growth ensureing cow mammary gland and other organs of health thereof, there is cure rate high, instant effect, treatment short treating period, the advantage such as have no side effect.

In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition for the treatment of milch cow hypogalactia, described pharmaceutical composition comprises following raw medicinal material: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Gymnadeniae, Radix seu Herba Gei aleppici, Pericarpium Citri Reticulatae, Radix Et Caulis Acanthopanacis Senticosi, Ganoderma, Herb Gynostemmae Pentaphylli, Fructus cari carvi, Fructus Jujubae, Radix Pseudostellariae, Radix hemerocalis plicatae, Nux Prinsepiae, Herba Limonii Gmelinii, Rhizoma Dioscoreae, Testis et penis callorhini, Herba Canscorae, Rhizoma panacis majoris, Radix Aleuritis Fordii, Rhizoma Curcumae, Semen thlaspis, Mylabris, Herba Gonostegiae hirtae and Cyananthus argernteus marg..

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Radix Astragali 10-25 weight portion, Rhizoma Atractylodis Macrocephalae 12-35 weight portion, Rhizoma Gymnadeniae 10-22 weight portion, Radix seu Herba Gei aleppici 13-27 weight portion, Pericarpium Citri Reticulatae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-32 weight portion, Ganoderma 15-35 weight portion, Herb Gynostemmae Pentaphylli 14-36 weight portion, Fructus cari carvi 13-31 weight portion, Fructus Jujubae 10-35 weight portion, Radix Pseudostellariae 13-34 weight portion, Radix hemerocalis plicatae 3-5 weight portion, Nux Prinsepiae 12-22 weight portion, Herba Limonii Gmelinii 13-33 weight portion, Rhizoma Dioscoreae 12-32 weight portion, Testis et penis callorhini 12-36 weight portion, Herba Canscorae 10-21 weight portion, Rhizoma panacis majoris 12-25 weight portion, Radix Aleuritis Fordii 3-5 weight portion, Rhizoma Curcumae 11-31 weight portion, Semen thlaspis 13-32 weight portion, Mylabris 10-30 weight portion, Herba Gonostegiae hirtae 13-36 weight portion and Cyananthus argernteus marg. 14-24 weight portion.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 20 weight portion, the Rhizoma Atractylodis Macrocephalae 32 weight portion, Rhizoma Gymnadeniae 15 weight portion, Radix seu Herba Gei aleppici 25 weight portion, Pericarpium Citri Reticulatae 28 weight portion, Radix Et Caulis Acanthopanacis Senticosi 25 weight portion, Ganoderma 30 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion, Fructus cari carvi 23 weight portion, Fructus Jujubae 35 weight portion, Radix Pseudostellariae 33 weight portion, Radix hemerocalis plicatae 3 weight portion, Nux Prinsepiae 22 weight portion, Herba Limonii Gmelinii 30 weight portion, Rhizoma Dioscoreae 25 weight portion, Testis et penis callorhini 36 weight portion, Herba Canscorae 20 weight portion, Rhizoma panacis majoris 22 weight portion, Radix Aleuritis Fordii 3 weight portion, Rhizoma Curcumae 31 weight portion, Semen thlaspis 32 weight portion, Mylabris 20 weight portion, Herba Gonostegiae hirtae 36 weight portion and Cyananthus argernteus marg. 14 weight portion.

Described pharmaceutical composition also comprises Radix Et Rhizoma Nardostachyos, Poria cum Radix Pini, Flos Loropetali (Herba Loropetali), Rhizoma Alismatis, Poria and the Rhizoma Anemarrhenae.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Astragali 10-25 weight portion, Rhizoma Atractylodis Macrocephalae 12-35 weight portion, Rhizoma Gymnadeniae 10-22 weight portion, Radix seu Herba Gei aleppici 13-27 weight portion, Pericarpium Citri Reticulatae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-32 weight portion, Ganoderma 15-35 weight portion, Herb Gynostemmae Pentaphylli 14-36 weight portion, Fructus cari carvi 13-31 weight portion, Fructus Jujubae 10-35 weight portion, Radix Pseudostellariae 13-34 weight portion, Radix hemerocalis plicatae 3-5 weight portion, Nux Prinsepiae 12-22 weight portion, Herba Limonii Gmelinii 13-33 weight portion, Rhizoma Dioscoreae 12-32 weight portion, Testis et penis callorhini 12-36 weight portion, Herba Canscorae 10-21 weight portion, Rhizoma panacis majoris 12-25 weight portion, Radix Aleuritis Fordii 3-5 weight portion, Rhizoma Curcumae 11-31 weight portion, Semen thlaspis 13-32 weight portion, Mylabris 10-30 weight portion, Herba Gonostegiae hirtae 13-36 weight portion, Cyananthus argernteus marg. 14-24 weight portion, Radix Et Rhizoma Nardostachyos 10-20 weight portion, Poria cum Radix Pini 10-30 weight portion, Flos Loropetali (Herba Loropetali) 12-32 weight portion, Rhizoma Alismatis 11-21 weight portion, Poria 12-32 weight portion and Rhizoma Anemarrhenae 14-24 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Astragali 20 weight portion, the Rhizoma Atractylodis Macrocephalae 32 weight portion, Rhizoma Gymnadeniae 15 weight portion, Radix seu Herba Gei aleppici 25 weight portion, Pericarpium Citri Reticulatae 28 weight portion, Radix Et Caulis Acanthopanacis Senticosi 25 weight portion, Ganoderma 30 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion, Fructus cari carvi 23 weight portion, Fructus Jujubae 35 weight portion, Radix Pseudostellariae 33 weight portion, Radix hemerocalis plicatae 3 weight portion, Nux Prinsepiae 22 weight portion, Herba Limonii Gmelinii 30 weight portion, Rhizoma Dioscoreae 25 weight portion, Testis et penis callorhini 36 weight portion, Herba Canscorae 20 weight portion, Rhizoma panacis majoris 22 weight portion, Radix Aleuritis Fordii 3 weight portion, Rhizoma Curcumae 31 weight portion, Semen thlaspis 32 weight portion, Mylabris 20 weight portion, Herba Gonostegiae hirtae 36 weight portion, Cyananthus argernteus marg. 14 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Poria cum Radix Pini 25 weight portion, Flos Loropetali (Herba Loropetali) 32 weight portion, Rhizoma Alismatis 21 weight portion, Poria 30 weight portion and the Rhizoma Anemarrhenae 22 weight portion.

The dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, Pericarpium Citri Reticulatae, Radix Et Caulis Acanthopanacis Senticosi, Ganoderma, Herb Gynostemmae Pentaphylli, Fructus cari carvi, Fructus Jujubae, Radix Pseudostellariae, Radix hemerocalis plicatae, Nux Prinsepiae and Herba Limonii Gmelinii are mixed in described ratio, with being the dissolve with ethanol of 85% ~ 95% relative to the determining alcohol of 3 ~ 5 times of mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Aleuritis Fordii, Rhizoma Curcumae, Semen thlaspis, Mylabris, Herba Gonostegiae hirtae and Cyananthus argernteus marg. are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The invention has the beneficial effects as follows: pharmaceutical composition of the present invention has spleen invigorating and regulates the flow of vital energy, effect of benefiting qi and nourishing blood, full and the nipple normal development of breast can also be promoted, milk is full, improves the immunity of milch cow, but also can be good at the normal growth ensureing cow mammary gland and other organs of health thereof, there is cure rate high, instant effect, treatment short treating period, the advantage such as have no side effect.

Detailed description of the invention

Chinese veterinarian thinks, kidney essense, i.e. the kidney vital essence of hiding.It derives from congenital essence, and relying constantly supplementing nutrition of acquired essence, is the material base of renal function activity, is body vital movement basis, plays an important role to the various physiological activity of body.Kidney qi, the gas of kidney essense instituteization life, refers to the physiological function that kidney vital essence produces in fact.Gas is in Chinese medicine, and referring to the most base substance forming human body and maintain human life activity, is the material base of zang-fu differentiation functional activity.Gas has the attribute of motion, and the athletic performance of gas is the functional activity of human body zang-fu differentiation.Zang-fu differentiation is the aggregate concept of structure and fuction dialectical unity.The digestion of ingesta and the absorption of nutrient substance, to transfer, be the physiological activity that under multiple internal organs such as taste, liver and gall, intestine and small intestine participate in jointly one is complicated, wherein spleen plays a leading role: the transportation capabilities of spleen mainly rely on temper the lucid yang sending up and the warm effect of spleen sun: the normal function of the spleen tending to ascent." people Na Shuigu, temper and rise " (" three-character medical verses annex internal organs "), " spleen rises and kind mill " (" four holy heart sources "), water paddy enters stomach, entirely relies spleen sun transporting for it.Therefore " spleen has one/sun, and can disappear one/water paddy; Spleen has ten/sun, and can disappear ten/water paddy " (" curing former ").

Pharmaceutical composition of the present invention is regulated the flow of vital energy with spleen invigorating, the principle of benefiting qi and nourishing blood, provide a kind of pharmaceutical composition for the treatment of milch cow hypogalactia, comprise following raw medicinal material: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Gymnadeniae, Radix seu Herba Gei aleppici, Pericarpium Citri Reticulatae, Radix Et Caulis Acanthopanacis Senticosi, Ganoderma, Herb Gynostemmae Pentaphylli, Fructus cari carvi, Fructus Jujubae, Radix Pseudostellariae, Radix hemerocalis plicatae, Nux Prinsepiae, Herba Limonii Gmelinii, Rhizoma Dioscoreae, Testis et penis callorhini, Herba Canscorae, Rhizoma panacis majoris, Radix Aleuritis Fordii, Rhizoma Curcumae, Semen thlaspis, Mylabris, Herba Gonostegiae hirtae, Cyananthus argernteus marg., Radix Et Rhizoma Nardostachyos, Poria cum Radix Pini, Flos Loropetali (Herba Loropetali), Rhizoma Alismatis, Poria and the Rhizoma Anemarrhenae.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Semen thlaspis: nature and flavor: pungent, tepor.1. " herbal classic ": " acrid in the mouth, tepor." 2. " not Lu ": " be nontoxic." cure mainly: control conjunctival congestion and swelling pain and shed tears.1. " herbal classic ": " eliminating impediment, tonifying five ZANG-organs, benefit is with nothing left for main improving eyesight, ophthalmalgia lacrimation." 2. " not Lu ": " treats trusted subordinate's lumbago." 3. " property of medicine opinion ": " treating the liver man gather, and eyes is red swollen."

Flos Loropetali (Herba Loropetali): nature and flavor: sweet in the mouth; Puckery; Property is put down.Gui Jing: and; Spleen; Large intestine channel.Cure mainly: clearing and antitussive; Astringing to arrest bleeding.Main cough due to lung-heat; Spitting of blood epistaxis; Have blood in stool; Dysentery; Have loose bowels; Metrorrhagia.

Poria cum Radix Pini: nature and flavor: sweet; Light; Property is put down.Gui Jing: the heart; Spleen channel.Cure mainly: mind calming; Calm the nerves; Diuretic.Main palpitation with fear; Forgetful; Forgetful insomnia; Infantile convulsion; Dysuria.

Cyananthus argernteus marg.: nature and flavor: sweet, bitter, temperature.Cure mainly: spleen invigorating dehumidifies, dredge the meridian passage.Cure mainly children's's breast poison (eating place milk) diarrhoea, rheumatalgia, traumatic injury.

Herba Gonostegiae hirtae: source: come from " Guizhou side's medicine among the people collection ".Nature and flavor: sweet; Micro-hardship; Cool in nature.Cure mainly: spleen invigorating removing food stagnancy; Inducing diuresis and reducing edema; Dissipating blood stasis stops blooding.Main acute mastitis; Toxic swelling; Dysentery; Dyspepsia; Abdominal pain due to retention of food; Glycoside amasss; Leukorrhagia; Edema; Dysuria; Dysmenorrhea; Traumatic injury; Hemoptysis; Spit blood; Traumatic hemorrhage.. " Traditional Chinese Medicine in Sichuan will " strengthening spleen, tonifying kidney.

Radix Aleuritis Fordii: source: " Traditional Chinese Medicine in Sichuan will ".Nature and flavor: pungent, cold, poisonous.1. " Traditional Chinese Medicine in Sichuan will ": " cold in nature, acrid in the mouth, slightly poisonous." 2. " Guizhou medical herbs ": " is cool in nature, acrid in the mouth." curing mainly: " Shaanxi Chinese herbal medicine ": " parasite killing, helps digestion and regulates the flow of vital energy, sharp expectorant.Control ascariasis, fullness and distention in the chest and hypochondrium, anorexia, asthma, scrofula."

Rhizoma Alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, urinary bladder channel.Cure mainly: diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.

Rhizoma panacis majoris: nature and flavor: bitter sweet, cold." Shaanxi Chinese herbal medicine ": " relieving convulsionly to relieve dizziness, high fever, infantile convulsions, epilepsy, etc., except rheumatism, stomach invigorating of regulating the flow of vital energy, pain relieving.Control infantile convulsion, rheumatic arthritis, stomachache, toxic swelling malignant boil."

Herba Canscorae: nature and flavor: 1. " Guangxi Chinese herbal medicine ": " the micro-sweet micro-hardship of taste, property is put down, nontoxic." 2. " the practical Chinese herbal medicine in Guangxi newly selects ": " mildly bitter flavor, cool in nature.Cure mainly: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Control cough due to lung-heat, hepatitis, leptospirosis, jaundice, chest pain, stomachache, the stasis of blood in traumatic injury, venom.1. " Guangxi Chinese herbal medicine ": " regulate the flow of vital energy, pain relieving, cough-relieving.Control cough due to lung-heat, heart peratodynia, venom." 2. " the practical Chinese herbal medicine in Guangxi newly selects ": " cool liver and gall, promoting blood circulation and stopping pain.To harness the Yellow River subcutaneous ulcer, hepatitis, chest pain, stomachache, internal traumatic injury." 3. Guangzhou air force " conventional Chinese herbal medicine handbook ": " controls acute bronchitis, pneumonia, acute gastritis, duodenitis."

Herba Limonii Gmelinii: nature and flavor: bitter, salty, temperature.Cure mainly: invigorate blood circulation, hemostasis, warming middle-JIAO and strengthening the spleen, strengthening by means of tonics.For menoxenia, dysfunctional uterine hemorrhage, bleeding hemorrhoids, gastric ulcer, insufficiency of the spleen edema.

Radix hemerocalis plicatae: source: " Kunming conventional medical herbs among the people ".Nature and flavor: sweet are flat.1. " Kunming conventional medical herbs among the people ": " property is put down, sweet in the mouth.Slightly poisonous." 2. " choosing of Yunnan Chinese herbal medicine ": " Gan Weixin is flat." cure mainly: nourish blood suppressing the hyperactive liver, inducing diuresis to remove edema.Control dizziness, tinnitus, cardiopalmus, lumbago, spit blood, epistaxis, large intestine hematochezia, edema, gonorrhea, pharyngalgia, acute mastitis.1. " Kunming conventional medical herbs among the people ": " tonify deficiency is stimulated the secretion of milk, suppressing the hyperactive liver diuresis, detumescence hemostasis." 2. " choosing of Yunnan Chinese herbal medicine ": " is calm, diuresis, detumescence.Control giddy, cardiopalmus, dysuria, edema, urinary tract infection, galactopoiesis is not enough, arthralgia." 3. " Yunnan Chinese herbal medicine ": " nourish blood tonify deficiency, heat clearing away."

Fructus Jujubae: nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach warp.Cure mainly: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Bark: antiinflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, metrorrhagia; Traumatic hemorrhage is controlled in external.Root: circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, redly to collapse, leucorrhea.

Radix Pseudostellariae: nature and flavor: sweet, micro-hardship is flat.Gui Jing: return spleen, lung meridian.Cure mainly: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.

Fructus cari carvi: nature and flavor: 1. " Chinese herbal medicine is commonly used in Tibet ": " warm in nature, taste is micro-pungent." 2. " plateau Chinese herbal treatment handbook ": " is warm in nature, and sweet in the mouth is pungent." return through: " plateau Chinese herbal treatment handbook ": " enters kidney, stomach warp." curing mainly: 1. " Chinese herbal medicine is commonly used in Tibet ": " fragrant stomach invigorating, wind dispelling is regulated the flow of vital energy and is treated for stomachache, stomachache, inguinal hernia." 2. " plateau Chinese herbal treatment handbook ": " wind dispelling method is trembled with fear, spleen benefiting and stimulating the appetite.Control cold stagnant lumbago, cold syndrome of the stomach vomiting."

The Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter, sweet, temperature.Gui Jing: return spleen, stomach warp.Cure mainly: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Pericarpium Citri Reticulatae: nature and flavor: bitter, pungent, temperature.Gui Jing: return lung, spleen channel.Cure mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Air making-up and spleen enlivening, benefit defends real table, ascending up spleen-Qi and Yang, poison holding sore, inducing diuresis to remove edema.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system for the Radix Astragali, soil in tonification.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.

Rhizoma Gymnadeniae: the herb medicine being the nourishing of old people's life lengthening, for the ginseng kind that treasure hands down is planted by family, there is cultivation in a small amount various places.In 2 or three year autumn after plantation, excavate the Rhizoma Gymnadeniae tuber that (or pulling out) only has 1.5 to 2.5 centimetres of footpath width, remove stem and leaf and fibrous root, put into boiling water pot after cleaning and boil to without Bai Xinwei degree, dry for subsequent use after dragging for.Its nature and flavor are sweet, micro-hardship, cool, have the kidney invigorating and essence nourishing, effect of regulating QI to relieve pain.Rhizoma Gymnadeniae is illiteracy, Tibetan medicine, and also use among the people, the traditional Chinese medical science is used less.Sweet, the micro-hardship of meridian distribution of property and flavor, cool, be slightly cold.Sweet in the mouth, property is put down.(1) " the conventional Chinese herbal medicine handbook in the north ": " sweet in the mouth, micro-hardship, cold nature.(2) " Chinese herbal medicine handbook is commonly used in Liaoning ": " sweet, micro-hardship, tepor." (3) " Chinese herbal medicine is commonly used in Sichuan ": " sweet, flat.Enter lung, spleen, stomach warp." (4) " Chinese herbal medicine handbook is commonly used in Qinghai ": " and pungent, bitter, temperature." (5) " national Chinese herbal medicine compilation ": " and sweet, micro-hardship, cool." function cures mainly: the kidney invigorating and essence nourishing, weak after being ill, cough, leucorrhea, traumatic injury, congestion swells and ache.Relieving cough and asthma, Yishen Jianpi, regulates the flow of vital energy and blood, pain relieving.Cure mainly cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.(1) " will planted by northeast medicine ": " make mucus, for poisoning and under rushing down; Steep in wine as strong, essence-replenishing preparation." (2) " Heilungkiang Chinese medicine among the people ": " steep in wine and control impotence." (3) " illustrated handbook planted by middle traditional Chinese medicines ": " repercussive.Control traumatic injury, hematocele is not all right." (4) " the conventional Chinese herbal medicine handbook in the north ": " the kidney invigorating benefit is empty, regulates the flow of vital energy and blood, promoting the circulation of blood.Control neurasthenia, chronic diarrhea, leucorrhea, chronic hemorrhage." (5) " Chinese herbal medicine handbook is commonly used in Heilungkiang ": " and take muscle reinforcing and bone strengthening for a long time, strong, essence by force, removing toxic substances.Control sexual neurasthenie, sexual impotence, YANG asthenia disease, and control enteritis, diarrhea." (6) " Chinese herbal medicine handbook is commonly used in northeast ": " supporing yang." (7) " Chinese herbal medicine is commonly used in Sichuan ": " blood yiqi, promoting the production of body fluid to quench thirst.Control cough and asthma due to lung deficiency, chronic consumptive disease weakness and emaciation, hypogalactia juice." (8) " Shaanxi Chinese herbal medicine ": " strengthening by means of tonics, spleen reinforcing lung moistening are calmed the nerves relieving convulsion, QI invigorating pain relieving.Control physical weakness, neurasthenia, impairment caused by overstrain, cough, asthma." (9) " Chinese herbal medicine is commonly used in Tibet ": " control chronic hepatitis." (10) " Chinese herbal medicine handbook is commonly used in Qinghai ": " warming the kidney to invigorate YANG.Control the lassitude loin and legs that suffers from a deficiency of the kidney unable, sexual impotence, spermatorrhea, frequent micturition." (11) " Shanxi Chinese medicinal herbal ": " pain relieving, hemostasis.Control trauma pain, spitting of blood, epistaxis, has blood in stool.”

Radix seu Herba Gei aleppici: analgesia, blood pressure lowering, regulating menstruation, expelling wind and removing dampness.For hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison is controlled in external, traumatic injury.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enters spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.The sweet A of Radix Et Caulis Acanthopanacis Senticosi is carotene, also containing this constituents in people Ginseng.The excretion of cholesterol can be promoted in human body, the too high disease of blood cholesterol level can be prevented and treated.The sweet B of Radix Et Caulis Acanthopanacis Senticosi is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, has short gonad, radioprotective, fatigue-resisting function, has the physiologically active similar to Ren Ginseng Saponin.Radix Et Caulis Acanthopanacis Senticosi is containing super oxidation disproportionation ferment SOD (Superoxidedimutase) complex, SOD has good anti-oxidation function, the effect of human immunity and the attack of opposing free radical can be strengthened, there is antioxidation, body immunity can be strengthened, prevent aging and promotion health.

Ganoderma: the Ganoderma that Ganoderma makes medicine is Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma, and its property of medicine is sweet, flat.GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote that liver is to the metabolism of medicine, poisonous substance, has definite curative effect for toxic hepatitis.Zoopery and clinical trial all show, Ganoderma can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is protective effect, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.Polysaccharide contained by Ganoderma, polypeptide etc. have obvious function of delaying senility.Extract energy exciting motion suppresses, mobility is reduced, coordination exercise is lacked of proper care, presents the sick effect in dose-dependent town, can curtail sleep to hexobarbital sleep effect, the time that central stimulants caffeine causes spasm and death can be extended, these results show, Ganoderma is inhibition effect to maincenter.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After small number of patients is taken medicine, there is the symptom such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.After taking Herb Gynostemmae Pentaphylli, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.Reaction that is excited to cerebral cortex and that suppress can keep suitable balance, has dual regulation to nervus centralis.There is excellent analgesia, sleeping, antitonic effect.In reduction myocardial wall anxiety, relax on the basis of cerebrovascular and peripheral vascular resistance, heart and brain vigor can be strengthened, strengthen coronary flow, relax arteriosclerosis, impel entirety to circulate more vigorous and smooth.Experiment proves, and the not rich Herb Gynostemmae Pentaphylli group that takes of diet, and and avoid meat and refuses to obey Herb Gynostemmae Pentaphylli group, make regular check on and compare, body inner bag is consolidated close with neutral fat content.Herb Gynostemmae Pentaphylli has benign transformed regulating action to body fat mass in human body as can be seen here.

Nux Prinsepiae: sweet, is slightly cold.Return Liver Channel.Nourishing the liver to improve visual acuity, wind-dispelling heat-dissipating.For conjunctival congestion and swelling pain, red and fester on the palpebral margin, the dark photophobia of order.1. " not Lu ": " be slightly cold, nontoxic." 2. " medical center bun is wanted ": " sweet salty, cold." enter liver, heart channel.1. " Thunder God concocts property of medicine solution ": " enter the heart, liver, spleen three warp." pathogenic wind expelling heat radiation, beneficial aquatic light.Three through all blood is also dirty, and blood obtains it and supports, then order disease is put down.All order diseases, at table, are worked as wind and heat dispersing, are suffered from a deficiency of the kidney at inner genus, insufficiency of blood, refreshing labor, should calm the nerves by kidney-replenishing blood-nourishing.Hypermetropia is that kidney water loses, and myopia is that fire is not enough.2. " jade seizes medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." effect: dispel the wind, heat radiation, nourishing the liver, improving eyesight.Control conjunctival congestion and swelling pain, dim shy the moon, the rotten many tear of the corner of the eyes, epistaxis.Also trusted subordinate's pathogenic heat are controlled, stagnation of QI fullness and oppression sensation in the epigastrium due to accumulation of phlegm.Moderns are only with treating eye.(CHEN Zang-Qi is said) raw foot of controlling is slept, and ripely controls sleeplessness." medical center bun want ": white Nux Prinsepiae, the same Semen Ziziphi Spinosae of achievement, raw then salty many, the use of spreading gods; Ripe then sweet many, the master of stable gods.Enter to know that it controls order disease, and do not know that its energy reinforcing the heart is of a specified duration.2, " herbal classic ": main trusted subordinate's pathogens agglomerating gas, improving eyesight, conjunctival congestion with ophthalmalgia hinders lacrimation.3, " WU Pu Bencao ": the strong will of invigorating middle warmer, improve visual and auditory acuity.4, " not Lu ": the order corner of the eyes that swells is rotten, to fullness and oppression sensation in the epigastrium due to accumulation of phlegm gas under the broken heart.5, " property of medicine opinion ": control epistaxis.6, supplement to the Herbal: raw foot of controlling is slept, ripely controls sleeplessness.7, " book on Chinese herbal medicine covers bamboo fish trap ": specially control ophthalmology, disappear the rotten string of upper lower eyelid swelling due to wind, except left and right corner of the eyes thermal boundary bulbar conjunctiva polyp, annealing arresting lacrimation, beneficial aquatic light.

Rhizoma Dioscoreae: sweet, flat, enters spleen, lung, kidney channel.Spleen benefiting and stimulating the appetite, boosting qi and nourishing yin, antidiarrheal arresting seminal emission.Cure mainly diarrhea due to hypofunction of the spleen, asthenia chronic cough, the diseases such as seminal emission, leukorrhagia frequent micturition of quenching one's thirst.

Testis et penis callorhini: salty in the mouth, hot in nature, returns liver.Warming the kidney tonifying YANG, benefit essence mends marrow.Control deficient impairment caused by overstrain, sexual impotence essence declines, premature ejaculation, waist knee flaccidity, trusted subordinate's pain.One, tonifying YANG YIN nourishing, kidney-supplementing liver-boosting, endocrine regulation.Its whip is put down, and enters liver the kidney invigorating.Be applicable to because of diseases such as sexual impotence, premature ejaculation, sexual disorder and the insomnia and dreamful sleep caused by the groan kidney deficiency such as damage of kidney-YIN, insufficiency of kidney-YANG, dizzy forgetful, soreness of waist and knee, neurasthenia and immunologic hypofunctions; Two, blood yiqi.Hemoglobin in Testis et penis callorhini and hemoglobin high, be applicable to blood deficiency gas weak person; Three, skin care skin Caring.Containing a large amount of viscous protein in Testis et penis callorhini, there is slow down aging, keep the function of elasticity of skin and moisture; Four, bone and muscle strengthening.Testis et penis callorhini is the kidney invigorating treasure, and kidney by force then can bone and muscle strengthening." Bencao Jingshu ": " deficiency of YIN heated and hectic fever due to YIN-deficiency chronic cough wait, and saltyly avoided.”

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.This product effect is similar to Rhizoma Sparganii, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.But warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Can the pain relieving of circulation of qi promoting removing food stagnancy, for eating accumulation, breast abdominal distention is vexed has a pain.Also can removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.Aromatic turmeric oil preparation has the growth of the multiple tumor strains such as the L615 leukemia of Mouse Ehrlich Carcinoma Cells, 615 mouse inbred liness and ascites hepatoma cells in vitro and obviously suppresses and destruction.

Mylabris: acrid in the mouth, warm in nature, poison greatly.Enter large intestine, small intestinal, liver, kidney channel.Counteracting toxic substances phagedenoma, removing blood stasis eliminating stagnation.Amplification on Canon of Materia Medica: " pregnant body people can not take, and is people's meat of bursting.Antigonorrheic is multiplex, pole bitter man, and You Yi considers." counteracting toxic substances phagedenoma, removing blood stasis eliminating stagnation.Main carbuncle, scrofula, stubborn dermatitis, amenorrhea, lump in the abdomen, cancerous protuberance.Yong Yu WEIJIA lump, stubborn dermatitis for many years, scrofula, wart, carbuncle is not burst, the dead flesh of malignant boil.Treatment rheumatalgia, neuralgia etc. stick acupoint therapy extremities joint, the rheumatalgia (comprising occupational benign arthritis, myofibrositis, rheumatic arthritis, the arthralgia etc. that causes because of neurovascular disorders or wound) of lower back and neuralgia (the reflex neuro pain etc. in intercostal neuralgia, Trigeminal neuralgia, operation or trauma scar district), the convalescent pain in the hepatic region of infectious hepatitis etc. with Mylabris, all have certain short term effect.

Radix Et Rhizoma Nardostachyos: acrid in the mouth, sweet, warm in nature; Return spleen, stomach warp.Fragrance row is loose, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can open spleen, adds in taste medicine less, gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, the therapeutic method to keep the adverse QI flowing downwards." to have fragrance row loose for Radix Et Rhizoma Nardostachyos, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Cure mainly coldness and pain in the epigastrium distension, anorexia, chest pain, toothache, tumbling down is grieved, beriberi edema, cramp caused by acute vomiting and diarrhea.Jatamansi volatile oil has faint antibacterial, wind dispelling and spasmolysis, to skin, mucosa without local irritation.Jatamansi is to rabbit hemostasis, and rabbit performance is to the bradykinesia, sleepy, the loss of appetite that stimulate.Radix Et Rhizoma Nardostachyos alcohol extract has blood pressure lowering and antiulcer action.

Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic, eliminating dampness by diuresis diuresis, spleen reinforcing, mind calming." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid.”

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

Embodiments provide a kind of pharmaceutical composition for the treatment of milch cow hypogalactia, be made up of the raw medicinal material of following parts by weight: the Radix Astragali 20 weight portion, the Rhizoma Atractylodis Macrocephalae 32 weight portion, Rhizoma Gymnadeniae 15 weight portion, Radix seu Herba Gei aleppici 25 weight portion, Pericarpium Citri Reticulatae 28 weight portion, Radix Et Caulis Acanthopanacis Senticosi 25 weight portion, Ganoderma 30 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion, Fructus cari carvi 23 weight portion, Fructus Jujubae 35 weight portion, Radix Pseudostellariae 33 weight portion, Radix hemerocalis plicatae 3 weight portion, Nux Prinsepiae 22 weight portion, Herba Limonii Gmelinii 30 weight portion, Rhizoma Dioscoreae 25 weight portion, Testis et penis callorhini 36 weight portion, Herba Canscorae 20 weight portion, Rhizoma panacis majoris 22 weight portion, Radix Aleuritis Fordii 3 weight portion, Rhizoma Curcumae 31 weight portion, Semen thlaspis 32 weight portion, Mylabris 20 weight portion, Herba Gonostegiae hirtae 36 weight portion and Cyananthus argernteus marg. 14 weight portion.

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 pharmaceutical composition 2

Embodiments provide a kind of pharmaceutical composition for the treatment of milch cow hypogalactia, be made up of the raw medicinal material of following parts by weight: the Radix Astragali 20 weight portion, the Rhizoma Atractylodis Macrocephalae 32 weight portion, Rhizoma Gymnadeniae 15 weight portion, Radix seu Herba Gei aleppici 25 weight portion, Pericarpium Citri Reticulatae 28 weight portion, Radix Et Caulis Acanthopanacis Senticosi 25 weight portion, Ganoderma 30 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion, Fructus cari carvi 23 weight portion, Fructus Jujubae 35 weight portion, Radix Pseudostellariae 33 weight portion, Radix hemerocalis plicatae 3 weight portion, Nux Prinsepiae 22 weight portion, Herba Limonii Gmelinii 30 weight portion, Rhizoma Dioscoreae 25 weight portion, Testis et penis callorhini 36 weight portion, Herba Canscorae 20 weight portion, Rhizoma panacis majoris 22 weight portion, Radix Aleuritis Fordii 3 weight portion, Rhizoma Curcumae 31 weight portion, Semen thlaspis 32 weight portion, Mylabris 20 weight portion, Herba Gonostegiae hirtae 36 weight portion, Cyananthus argernteus marg. 14 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Poria cum Radix Pini 25 weight portion, Flos Loropetali (Herba Loropetali) 32 weight portion, Rhizoma Alismatis 21 weight portion, Poria 30 weight portion and the Rhizoma Anemarrhenae 22 weight portion.

The first step, Pericarpium Citri Reticulatae, Radix Et Caulis Acanthopanacis Senticosi, Ganoderma, Herb Gynostemmae Pentaphylli, Fructus cari carvi, Fructus Jujubae, Radix Pseudostellariae, Radix hemerocalis plicatae, Nux Prinsepiae and Herba Limonii Gmelinii are mixed in described ratio, with being the dissolve with ethanol of 90% relative to the determining alcohol of 4 times of mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Aleuritis Fordii, Rhizoma Curcumae, Semen thlaspis, Mylabris, Herba Gonostegiae hirtae and Cyananthus argernteus marg. are mixed in described ratio, add the ethanol of the determining alcohol 90% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the mastic of 1.22, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 1.5 times relative to the mixture quality obtained, again heat decoction 1.5 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 100 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The toxicity test of pharmaceutical composition:

1, trial drug

Choose Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 32g, Rhizoma Gymnadeniae 15g, Radix seu Herba Gei aleppici 25g, Pericarpium Citri Reticulatae 28g, Radix Et Caulis Acanthopanacis Senticosi 25g, Ganoderma 30g, Herb Gynostemmae Pentaphylli 35g, Fructus cari carvi 23g, Fructus Jujubae 35g, Radix Pseudostellariae 33g, Radix hemerocalis plicatae 3g, Nux Prinsepiae 22g, Herba Limonii Gmelinii 30g, Rhizoma Dioscoreae 25g, Testis et penis callorhini 36g, Herba Canscorae 20g, Rhizoma panacis majoris 22g, Radix Aleuritis Fordii 3g, Rhizoma Curcumae 31g, Semen thlaspis 32g, Mylabris 20g, Herba Gonostegiae hirtae 36g and Cyananthus argernteus marg. 14g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Contrast test

Miao Fu plant of Heshun County of Shanxi Province, in by the end of December, 2012, find the milch cow of 300 1.5 years old mean aves nearly, occur that breast is in various degree tightly little in first lactation period, nipple cripetura, outward appearance is inmature, agalactosis, refusal suckling, the thin deficiency of vital energy of body, or run into hot summer high temperature season milch cow appetite and die-off or do not eat.

From above-mentioned 300 cow heads, choose 180,180 cow heads are divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, the ill milch cow of three groups all without significant difference, has comparability in body weight, the state of an illness etc.Embodiment group 1, embodiment group 2 and matched group use the powder of the injectable powder of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively; Wherein, injectable powder adopts subcutaneous injection, each 60mg/kg, twice daily, and injection 6 days continuously; The using method of powder be by powder according in the part by weight conventional feed of 7g:480g, feed continuously 6 days; Conventional medicament is venae subcutaneae injection pituitrin 50 unit, continuous 6 days, conventional feed of feeding.Experimental period is 6 days, each group of ill milch cow body weight is taken respectively before and after experiment, period records recovery from illness situation and the death toll of ill milch cow, calculate cure rate, the average lactation amount of every cow head, average daily ingestion amount and average body condition divide (BCS), and cure time of number and compare, result is as shown in table 1, table 2 and table 3.Wherein, cure: normally, milk is full, and no longer include the phenomenon that appetite die-offs or do not eat, breast is full for breast and nipple, and nipple recovers normal; Invalid: clinical symptoms is not improved.

The therapeutic effect synopsis of each experimental group milch cow of table 1

Data from table 1: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has advantage that is evident in efficacy, cheap, that have no side effect in treatment milch cow hypogalactia.

Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 has toxic and side effects advantage little, evident in efficacy in treatment milch cow hypogalactia, but also can be good at the normal growth ensureing cow mammary gland and other organs of health thereof.

In each experimental group of table 2, the average lactation amount of every cow head, average daily ingestion amount and average body condition divide the therapeutic effect synopsis of (BCS)

Group	Average lactation amount (kg/d)	Average daily ingestion amount (kg/d)	Average body condition divides (BCS)
				Embodiment group 1	22.7±5.43	28.2±0.4	2.7±0.25
Embodiment group 2	25.3±5.43	31.9±0.4	3.0±0.25
				Matched group	18.9±5.43	25.9±0.4	1.5±0.25

Data from table 2: average lactation amount and the average daily ingestion amount of embodiment group 1 and embodiment group 2 all have growth than matched group, improve 3.8kg/d, 6.4kg/d and 2.3kg/d, 6kg/d respectively.The average body condition of embodiment group 1 and embodiment group 2 divides (BCS) to make moderate progress relative to matched group.

Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 is in treatment milch cow hypogalactia, there is high, the average daily ingestion amount of average lactation amount also increase, average body condition divides (BCS) also relatively to make moderate progress, breast is full and nipple is normal, milk is full, no longer includes the phenomenon that appetite die-offs or do not eat.

The time comparative example (%) of number of fully recovering afterwards for 6 days treated respectively by table 3 respectively group

Group	Number of cases	1-2 days	3-4 days	5-6 days
					Embodiment group 1	60	（56）93.3%	（4）6.7%	（0）0%
Embodiment 2	60	（58）96.7%	（2）3.3%	（0）0%
					Matched group	43	（1）2.3%	（3）7%	（39）90.7%

Data from table 3: pharmaceutical composition of the present invention, to treatment milch cow hypogalactia, relative to conventional medicament on therapeutic effect, has significant improvement, obviously shortens and treat the course for the treatment of.

Model case:

In January, 2014 Shanxi Hua Xin plant the milch cow of 450 1.5 years old mean aves, nearly in first lactation period, 160 milch cows occur that breast is in various degree tightly little, nipple cripetura, outward appearance is inmature, agalactosis, refusal suckling, the thin deficiency of vital energy of body, or run into hot summer high temperature season milch cow appetite and die-off or the symptom such as not eat.Choose 50 ill milch cows wherein, start to feed and be added with the feedstuff of the embodiment of the present invention 2 powder, powder is mixed in conventional feed according to 7g:480g weight ratio, feed 6 days, within 2nd day, ill milch cow symptom is obviously improved, within 3rd day, 50 milch cows are all fully recovered, after continuing to feed 4 days, compared with healthy cow, breast and nipple normal, milk is full, and no longer include the phenomenon that appetite die-offs or do not eat, breast is full, nipple recovers normal, compared with healthy cow, average lactation amount height and average daily ingestion amount increase, and average body condition divides (BCS) also relatively to make moderate progress.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the pharmaceutical composition of milch cow hypogalactia for one kind, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Gymnadeniae, Radix seu Herba Gei aleppici, Pericarpium Citri Reticulatae, Radix Et Caulis Acanthopanacis Senticosi, Ganoderma, Herb Gynostemmae Pentaphylli, Fructus cari carvi, Fructus Jujubae, Radix Pseudostellariae, Radix hemerocalis plicatae, Nux Prinsepiae, Herba Limonii Gmelinii, Rhizoma Dioscoreae, Testis et penis callorhini, Herba Canscorae, Rhizoma panacis majoris, Radix Aleuritis Fordii, Rhizoma Curcumae, Semen thlaspis, Mylabris, Herba Gonostegiae hirtae and Cyananthus argernteus marg..

2. the pharmaceutical composition for the treatment of milch cow hypogalactia according to claim 1, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Radix Astragali 10-25 weight portion, Rhizoma Atractylodis Macrocephalae 12-35 weight portion, Rhizoma Gymnadeniae 10-22 weight portion, Radix seu Herba Gei aleppici 13-27 weight portion, Pericarpium Citri Reticulatae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-32 weight portion, Ganoderma 15-35 weight portion, Herb Gynostemmae Pentaphylli 14-36 weight portion, Fructus cari carvi 13-31 weight portion, Fructus Jujubae 10-35 weight portion, Radix Pseudostellariae 13-34 weight portion, Radix hemerocalis plicatae 3-5 weight portion, Nux Prinsepiae 12-22 weight portion, Herba Limonii Gmelinii 13-33 weight portion, Rhizoma Dioscoreae 12-32 weight portion, Testis et penis callorhini 12-36 weight portion, Herba Canscorae 10-21 weight portion, Rhizoma panacis majoris 12-25 weight portion, Radix Aleuritis Fordii 3-5 weight portion, Rhizoma Curcumae 11-31 weight portion, Semen thlaspis 13-32 weight portion, Mylabris 10-30 weight portion, Herba Gonostegiae hirtae 13-36 weight portion and Cyananthus argernteus marg. 14-24 weight portion.

3. the pharmaceutical composition for the treatment of milch cow hypogalactia according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: the Radix Astragali 20 weight portion, the Rhizoma Atractylodis Macrocephalae 32 weight portion, Rhizoma Gymnadeniae 15 weight portion, Radix seu Herba Gei aleppici 25 weight portion, Pericarpium Citri Reticulatae 28 weight portion, Radix Et Caulis Acanthopanacis Senticosi 25 weight portion, Ganoderma 30 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion, Fructus cari carvi 23 weight portion, Fructus Jujubae 35 weight portion, Radix Pseudostellariae 33 weight portion, Radix hemerocalis plicatae 3 weight portion, Nux Prinsepiae 22 weight portion, Herba Limonii Gmelinii 30 weight portion, Rhizoma Dioscoreae 25 weight portion, Testis et penis callorhini 36 weight portion, Herba Canscorae 20 weight portion, Rhizoma panacis majoris 22 weight portion, Radix Aleuritis Fordii 3 weight portion, Rhizoma Curcumae 31 weight portion, Semen thlaspis 32 weight portion, Mylabris 20 weight portion, Herba Gonostegiae hirtae 36 weight portion and Cyananthus argernteus marg. 14 weight portion.

4. the pharmaceutical composition of the treatment milch cow hypogalactia according to any one of claim 1-3, it is characterized in that, described pharmaceutical composition also comprises Radix Et Rhizoma Nardostachyos, Poria cum Radix Pini, Flos Loropetali (Herba Loropetali), Rhizoma Alismatis, Poria and the Rhizoma Anemarrhenae.

5. the pharmaceutical composition of the treatment milch cow hypogalactia according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Astragali 10-25 weight portion, Rhizoma Atractylodis Macrocephalae 12-35 weight portion, Rhizoma Gymnadeniae 10-22 weight portion, Radix seu Herba Gei aleppici 13-27 weight portion, Pericarpium Citri Reticulatae 10-30 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-32 weight portion, Ganoderma 15-35 weight portion, Herb Gynostemmae Pentaphylli 14-36 weight portion, Fructus cari carvi 13-31 weight portion, Fructus Jujubae 10-35 weight portion, Radix Pseudostellariae 13-34 weight portion, Radix hemerocalis plicatae 3-5 weight portion, Nux Prinsepiae 12-22 weight portion, Herba Limonii Gmelinii 13-33 weight portion, Rhizoma Dioscoreae 12-32 weight portion, Testis et penis callorhini 12-36 weight portion, Herba Canscorae 10-21 weight portion, Rhizoma panacis majoris 12-25 weight portion, Radix Aleuritis Fordii 3-5 weight portion, Rhizoma Curcumae 11-31 weight portion, Semen thlaspis 13-32 weight portion, Mylabris 10-30 weight portion, Herba Gonostegiae hirtae 13-36 weight portion, Cyananthus argernteus marg. 14-24 weight portion, Radix Et Rhizoma Nardostachyos 10-20 weight portion, Poria cum Radix Pini 10-30 weight portion, Flos Loropetali (Herba Loropetali) 12-32 weight portion, Rhizoma Alismatis 11-21 weight portion, Poria 12-32 weight portion and Rhizoma Anemarrhenae 14-24 weight portion.

6. the pharmaceutical composition of the treatment milch cow hypogalactia according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Astragali 20 weight portion, the Rhizoma Atractylodis Macrocephalae 32 weight portion, Rhizoma Gymnadeniae 15 weight portion, Radix seu Herba Gei aleppici 25 weight portion, Pericarpium Citri Reticulatae 28 weight portion, Radix Et Caulis Acanthopanacis Senticosi 25 weight portion, Ganoderma 30 weight portion, Herb Gynostemmae Pentaphylli 35 weight portion, Fructus cari carvi 23 weight portion, Fructus Jujubae 35 weight portion, Radix Pseudostellariae 33 weight portion, Radix hemerocalis plicatae 3 weight portion, Nux Prinsepiae 22 weight portion, Herba Limonii Gmelinii 30 weight portion, Rhizoma Dioscoreae 25 weight portion, Testis et penis callorhini 36 weight portion, Herba Canscorae 20 weight portion, Rhizoma panacis majoris 22 weight portion, Radix Aleuritis Fordii 3 weight portion, Rhizoma Curcumae 31 weight portion, Semen thlaspis 32 weight portion, Mylabris 20 weight portion, Herba Gonostegiae hirtae 36 weight portion, Cyananthus argernteus marg. 14 weight portion, Radix Et Rhizoma Nardostachyos 20 weight portion, Poria cum Radix Pini 25 weight portion, Flos Loropetali (Herba Loropetali) 32 weight portion, Rhizoma Alismatis 21 weight portion, Poria 30 weight portion and the Rhizoma Anemarrhenae 22 weight portion.

7. the pharmaceutical composition of the treatment milch cow hypogalactia according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

8. the pharmaceutical composition of the treatment milch cow hypogalactia according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

9. a preparation method for the pharmaceutical composition of the treatment milch cow hypogalactia as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

10. a preparation method for the pharmaceutical composition of the treatment milch cow hypogalactia as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps: