CN101143177A - Medicine for preventing and treating postpartum disease of cow - Google Patents
Medicine for preventing and treating postpartum disease of cow Download PDFInfo
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Abstract
The invention discloses a drug for preventing and remedying the post partum diseases of the dairy cow, which mainly comprises the following drugs of a motherwort, a cowherb seed, a safflower, a Szechwan lovage rhizome, a white peony root, a cooked rehmannia root, a dangshen, an angelica, a hawthorn, a dried tangerine peel and a liquorice which are gotten for selecting the fine herbs and removing the impurity, air-drying, crushing and mixing and then are weighed and packed according to the weight portion to preparing for dispersed preparation or liquid preparation. The drug of the invention has very good curative effect towards the dairy cow with the post partum lochia, retained afterbirth, dysmenorrheal, promoting blood circulation for removing blood stasis, bleeding, anorexia, agalactia or being hypogalactous. Compared with the similar products, the invention is economical, substantial, convenient and effective and integrates health care and treatment as a whole and has the advantages of wide medicine source, long curative effect, low cost and not easily causing recrudescence, and the invention solves the problem of drug residue, which is in favor of the health of the dairy cow and has the meaning for actively popularizing.
Description
[technical field]
The present invention relates to a kind of veterinary drug, the medicine of specifically a kind of Chinese crude drug prevention and treatment cow disease.
[background technology]
Present domestic livestock products industry, the antibiotic medicine residue problem is rather outstanding, has badly influenced people's health safety issues.And beating now green, healthy, a lot of so-called product of plate efficiently on the veterinary drug market, in order to reduce cost, to improve drug effect, reaching maximum profit, has plenty of the Chinese herbal medicine inferior of employing, have plenty of short-term and pursue curative effect, add western medicine composition in the Chinese herbal medicine, but externally title all is pure Chinese herbal and crude drugs preparations.Therefore, how just can reach real safe, efficient, be the problem that our national drug industry is paid close attention to always.Postpartum disease of cow comprises postpartum paralysis (body nihility power), placenta retention, endometritis, ketoacidosis, puerperal mastitis and agalactia hypogalactia etc.Milch cow physiological situation in puerperal generation great variety, immunity reduce, and are the stages occurred frequently of various diseases, in case morbidity, gently then milk yield reduce sharply or influence after breed, heavy then dead, lose huge.At present, commercially available milch cow medicine or function singleness, or unsatisfactory curative effect, and all based on treatment, as publication number be: the CN1970033A patent application discloses the bacillary and medicine compositions of a kind of treatment milch cow; Notification number is that the Chinese patent of CN1186086C discloses a kind of " milch cow composition for preventing and treating bacterial diseases of young ", owing to added the Western medicine rifampicin, although 40-80% discharges through bile, is difficult to guarantee the dairy cow milk quality, and has caused drug waste to a certain degree.
[summary of the invention]
Technical problem to be solved by this invention is exactly the medicine that a kind of prevention and treatment postpartum disease of cow are provided at postpartum disease of cow, have curative effect length, drug residue free, cost low, be not easy advantage such as recurrence, milch cow tonify deficiency in puerperal, activating blood circulation to dissipate blood stasis, antalgic, the short food of lactogenesis are had good result.
The technical solution used in the present invention is:
The medicine of a kind of prevention and treatment postpartum disease of cow mainly is made up of the medicine of following composition by weight: Herba Leonuri 90-110, Semen Vaccariae 40-60, Flos Carthami 50-70 part, Rhizoma Chuanxiong 40-50 part Radix Paeoniae Alba 40-50, Radix Rehmanniae Preparata 55-65, Radix Codonopsis 35-45, Radix Angelicae Sinensis 35-45, Fructus Crataegi 70-90, Pericarpium Citri Reticulatae 25-35, Radix Glycyrrhizae 30-40.
The medicine of this prevention and treatment postpartum disease of cow adopts following composition by weight better effects if: Herba Leonuri 95-105, Semen Vaccariae 45-55, Flos Carthami 55-65 part, Rhizoma Chuanxiong 42-48 part Radix Paeoniae Alba 42-48, Radix Rehmanniae Preparata 58-63, Radix Codonopsis 38-42, Radix Angelicae Sinensis 38-42, Fructus Crataegi 75-85, Pericarpium Citri Reticulatae 28-33, Radix Glycyrrhizae 32-38.
The medicine of a kind of prevention and treatment postpartum disease of cow is made up of the medicine of following composition by weight: Herba Leonuri 100, Semen Vaccariae 50, Flos Carthami 60, Rhizoma Chuanxiong 45, the Radix Paeoniae Alba 45, Radix Rehmanniae Preparata 60, Radix Codonopsis 40, Radix Angelicae Sinensis 40, Fructus Crataegi 80, Pericarpium Citri Reticulatae 30, Radix Glycyrrhizae 35.
The medicine of a kind of prevention and treatment postpartum disease of cow is made up of the medicine of following composition by weight: Herba Leonuri 95, Semen Vaccariae 50, Flos Carthami 55, Rhizoma Chuanxiong 48, the Radix Paeoniae Alba 42, Radix Rehmanniae Preparata 63, Radix Codonopsis 45, Radix Angelicae Sinensis 45, Fructus Crataegi 75, Pericarpium Citri Reticulatae 25, Radix Glycyrrhizae 32.
The medicine of a kind of prevention and treatment postpartum disease of cow is made up of the medicine of following composition by weight: Herba Leonuri 105, Semen Vaccariae 55, Flos Carthami 50, Rhizoma Chuanxiong 40, the Radix Paeoniae Alba 40, Radix Rehmanniae Preparata 55, Radix Codonopsis 35, Radix Angelicae Sinensis 35, Fructus Crataegi 87, Pericarpium Citri Reticulatae 35, Radix Glycyrrhizae 38.
Above mentioned each Chinese herbal medicine carries out preferred remove impurity, and air-dry, pulverizing, mixing are weighed by weight then, packed, various dosage forms such as preparation powder, water preparation.
In the medicine each component of the present invention: Herba Leonuri, Semen Vaccariae are monarch drug, have the effect of the silt of invigorating blood circulation, dispel, diuretic, detumescence, heat-clearing and toxic substances removing, dredging collateral for promoting lactation, the silt detumescence of loosing; Flos Carthami, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata are ministerial drug, have promoting blood circulation to remove blood stasis, promoting QI circulation for relieving depression, clear nourishing the liver blood, muscles and tendons relaxing to alleviate pain, enrich blood, the effect of YIN nourishing; Being equipped with Radix Codonopsis, Radix Angelicae Sinensis, Fructus Crataegi, Pericarpium Citri Reticulatae is messenger drug, invigorating the spleen and replenishing QI, strengthening the spleen and stomach is arranged, the effect of loose silt pain relieving, loosening bowel to relieve constipation, dyspepsia and intestinal stasis relieving, antidiarrheal diuretic; With Radix Glycyrrhizae for making, QI invigorating and in, lung moistening, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, relieving spasm to stop pain.Then this medicine has hemopoietic QI invigorating, activating blood circulation to dissipate blood stasis, promotion uterine contraction; Enhance immunity, the antiinflammatory diuretic; Effects such as promoting digestion and invigorating the stomach.
The beneficial effect that the present invention can reach is:
1, medicine of the present invention has goodish therapeutical effect to milch cow lochia, placenta retention, dysmenorrhea, activating blood circulation to dissipate blood stasis, hemorrhage, anorexia, agalactia or hypogalactia, compares with like product, economic, material benefit, convenient, efficient, integrate health care and treat.
2, the present invention is owing to all adopt Chinese herbal medicine to make raw material, compare with like product on the market with antibiotic, have that the medicine source is wide, curative effect is long, cost is low, be not easy advantages such as recurrence, and solved the drug residue problem, be of value to milk cow health, have the meaning of positive popularization.
3, to the test contrast of over one hundred cow head, prevention and therapeutic efficiency, cost accounting had all reached more satisfactory effect to medicine of the present invention through over the past two years.
The clinical trial material:
1, therapeutic test
1.1, test material
The Henan Province milch cow breeds 91 of center and peripheral milch cow sub-district ill cows in puerperal; Medicine of the present invention, penicillin (the North China pharmacy of 4,000,000 units) calcium gluconate (10%). health in puerperal (middle peasant company), ketoboidies fast detecting pipe.
1.2, sick cattle criterion
Puerperal, retained afterbirth was a placenta retention more than 12 hours; Lochia uterina is serious, inappetence, and it is too high to detect the ketoboidies level, and the milch cow of walking shakiness, fever, lethargy is the puerperal disease cattle.
1.3 test method and administrated method
In year June in March, 2006 to 2007, the our company and the milch cow that falls ill peripheral puerperal are carried out the multiple therapy methods effect observation.This test is divided into three groups: first group is test group, adopts medicine medicine treatment of the present invention; Second group is matched group 1, and adopting western medicine is that penicillin (6 of 4,000,000 units, North China pharmacy) calcium gluconate (10%1000ml) carries out intravenous injection, once a day, and logotype two days; The 3rd group is matched group 2, adopts on the market existing like product " health in puerperal " (middle peasant company) to treat, every day potion, logotype three days is carried out medication according to its explanation.
The administrated method of medicine of the present invention: get each crude drug by above-mentioned weight proportion and amount to 585g, remove impurity is behind air-dry, pulverizing, the mixing, add water 3500ml, decoct 1.5 hours, get its medicinal liquid, keep former medicine, add water then and decoct again, taking liquid again, the medicinal liquid of being got for twice altogether 1000ml to carry out mixing be potion, with brown sugar 0.5Kg, yellow wine 1000ml for drawing, Niu Jinhang gavages to puerperal disease, and 1 dose every other day, 3 doses of logotypes.
1.4, curative effect determinate standard
A, criterion of cure: milch cow appetite is normal, afterbirth normally comes off, recover of uterus, ketoboidies detect normal.
B, effective standard: milch cow appetite is recovered to some extent, afterbirth is deviate from, lochia uterina reduces, ketoboidies reduces.
C, invalid standard: the milch cow state of an illness is not felt any better.
1.5, result and analysis
| Cure | Effectively | Invalid | Amount to | |
| Test group | 22 | 8 | 2 | 32 |
| Matched group 1 | 18 | 9 | 2 | 29 |
| Matched group 2 | 9 | 14 | 7 | 30 |
1.5.1, totally 32 of test group milch cows in puerperal, wherein cure 22,8 of certain effect are arranged, invalid final 2 of eliminating.Wherein greatly obvious to placenta retention, not dietetic therapy in puerperal therapeutic effect, to beginning that positive effect was arranged in general 3 days after the milch cow medication, can reach satisfied effect substantially about a week, and tracing observation, it is less to fall ill once more.
1.5.2,29 of matched group 1 treatment puerperal disease milch cows, cure 18,9 of certain effect are arranged, invalid 2.Wherein obvious to ketoacidosis, metritis effect, invalid case continues medication and is difficult for curing.
1.5.3, fall ill puerperal only 30 of cattle of matched group 2 specific aims treatment, wherein cure 9,14 of certain effects are arranged, invalid 7.
1.5.4 result and analysis
The test group milch cow: cure rate is 68.75%, and effective percentage is 25%, and inefficiency is 6.25%;
Matched group 1 milch cow: cure rate is 62.06%, and effective percentage is 31.04%, and inefficiency is 6.9%;
Matched group 2 milch cows: cure rate is 30%, and effective percentage is 46.67%, and inefficiency is 23.33%.
Through more as can be seen: cured substance rate of the present invention is the highest, and inefficiency is minimum; Medicine of the present invention and Western medicine antibiotic therapy result difference are little, but, because of drug residue, need abandon one week of milk after the cured by antibiotics such as penicillin, also than medicine height of the present invention, Western medicine costs an arm and a leg the tracing observation relapse rate in addition, comprehensive loss is big than medicine cost of the present invention; And puerperal health compare price with this medicine suitable, but part businessman is profit-push, the content of drug deficiency also has, and is single with the medicine composition treatment, can not reach the purpose to milch cow Comprehensive Treatment in puerperal.As seen: medicine of the present invention than other two groups have drug residue free, be difficult for recurrence, advantage such as cost is low, therapeutic effect is obvious.
2, prophylactic tria
2.1 time, place
Experimental period is year November in June, 2006 to 2006.Center, ancient cooking vessel unit cattle farm and middle lotus cattle farm are bred the Henan Province milch cow respectively in the experiment place.
2.2 grouping
The same period fresh cow be divided into 2 groups immediately, match processing.
2.3 prevention method
Test group: get each crude drug by above-mentioned weight proportion and amount to 585g, remove impurity is behind air-dry, pulverizing, the mixing, add water 3500ml, decoct 1.5 hours, get its medicinal liquid, keep former medicine, adding water then decocts again, taking liquid again carries out mixing to the medicinal liquid of being got for twice, about admixing medical solutions 3000ml, add brown sugar 0.5Kg, yellow wine 1000ml for drawing, allow puerperal milch cow drink immediately; Matched group is not drunk medicine of the present invention.Two groups puerperal welfare, raise identical.
2.4 after the effect observation medication to 90 days observed and recorded cow diseases and breeding situation.Observation situation such as following table:
| Placenta retention | Metritis | Mastitis | Normally oestrus | First non-return rate | Amount to | |
| Test group | 5％(1/20) | 5％(1/20) | 10％(2/20) | 80％(16/20) | 55％ | 20 |
| Matched group | 15％(3/20) | 20％(4/20) | 20％(4/20) | 45％(9/20) | 41.4％ | 20 |
2.5 result and analysis
As can be seen from the above table, after the test group medication, metritis, mastitis, that placenta retention ox head number accounts for overall test head number average is obviously low than the blank group, and cows morbidity ratio also has obvious reduction, and first non-return rate is than matched group height.Adopt paired experiment significance test of difference-t check, placenta retention in test group and the matched group, metritis sickness rate, mastitis sickness rate (P＜0.01) difference are extremely remarkable, and the situation of normally oestrusing and first non-return rate (P＜0.01) difference is extremely remarkable.
[specific embodiment]
Embodiment 1: the medicine of this prevention and treatment postpartum disease of cow, form by the medicine of following weight:
Herba Leonuri 100g, Semen Vaccariae 50g, Flos Carthami 60g, Rhizoma Chuanxiong 45g, Radix Paeoniae Alba 45g, Radix Rehmanniae Preparata 60g, Radix Codonopsis 40g, Radix Angelicae Sinensis 40g, Fructus Crataegi 80g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 35g.Get above Chinese herbal medicine by weight, preferred remove impurity, air-dry, pulverizing, mixing are weighed then, are packed, and make powder.
Embodiment 2: the medicine of this prevention and treatment postpartum disease of cow, form by the medicine of following weight: Herba Leonuri 95g, Semen Vaccariae 50g, Flos Carthami 55g, Rhizoma Chuanxiong 48g, Radix Paeoniae Alba 42g, Radix Rehmanniae Preparata 63g, Radix Codonopsis 45g, Radix Angelicae Sinensis 45g, Fructus Crataegi 75g, Pericarpium Citri Reticulatae 25g, Radix Glycyrrhizae 32g.Get above Chinese herbal medicine by weight, preferred remove impurity, air-dry, pulverizing, mixing, add water 3200ml, decoct 100 minutes, get its medicinal liquid, keep former medicine, add water then and decoct, taking liquid again carries out mixing to the medicinal liquid of being got for twice, become the bag packing, every bag of 1000ml is equipped with brown sugar (0.5kg) yellow wine (1000ml) for drawing, and gavages or drinks.
Embodiment 3: the medicine of this prevention and treatment postpartum disease of cow, form by the medicine of following weight: Herba Leonuri 15g, Semen Vaccariae 55g, Flos Carthami 50g, Rhizoma Chuanxiong 40g, Radix Paeoniae Alba 40g, Radix Rehmanniae Preparata 55g, Radix Codonopsis 35g, Radix Angelicae Sinensis 35g, Fructus Crataegi 87g, Pericarpium Citri Reticulatae 35g, Radix Glycyrrhizae 38g.Get above Chinese herbal medicine by weight, preferred remove impurity, air-dry, pulverizing, mixing add water 3500ml, decoct 2 hours, get its medicinal liquid, keep former medicine, add water then and decoct again, again taking liquid, the medicinal liquid 500ml that is got for twice is carried out mixing, become the bag packing, every bag of 500ml gavages.
Claims (6)
1. a medicine that prevents and treat postpartum disease of cow is characterized in that being made of the medicine of following composition by weight: Herba Leonuri 90-110, Semen Vaccariae 40-60, Flos Carthami 50-70 part, Rhizoma Chuanxiong 40-50 part, Radix Paeoniae Alba 40-50, Radix Rehmanniae Preparata 55-65, Radix Codonopsis 35-45, Radix Angelicae Sinensis 35-45, Fructus Crataegi 70-90, Pericarpium Citri Reticulatae 25-35, Radix Glycyrrhizae 30-40.
2. the medicine of prevention as claimed in claim 1 and treatment postpartum disease of cow is characterized in that adopting the crude drug of following composition by weight to constitute: Herba Leonuri 95-105, Semen Vaccariae 45-55, Flos Carthami 55-65, Rhizoma Chuanxiong 42-48, Radix Paeoniae Alba 42-48, Radix Rehmanniae Preparata 58-63, Radix Codonopsis 38-42, Radix Angelicae Sinensis 38-42, Fructus Crataegi 75-85, Pericarpium Citri Reticulatae 28-33, Radix Glycyrrhizae 32-38.
3. the medicine of prevention as claimed in claim 1 and treatment postpartum disease of cow is characterized in that adopting the crude drug of following composition by weight to constitute: Herba Leonuri 100, Semen Vaccariae 50, Flos Carthami 60, Rhizoma Chuanxiong 45, the Radix Paeoniae Alba 45, Radix Rehmanniae Preparata 60, Radix Codonopsis 40, Radix Angelicae Sinensis 40, Fructus Crataegi 80, Pericarpium Citri Reticulatae 30, Radix Glycyrrhizae 35.
4. the medicine of prevention as claimed in claim 1 and treatment postpartum disease of cow is characterized in that adopting the crude drug of following composition by weight to constitute: Herba Leonuri 95, Semen Vaccariae 50, Flos Carthami 55, Rhizoma Chuanxiong 48, the Radix Paeoniae Alba 42, Radix Rehmanniae Preparata 63, Radix Codonopsis 45, Radix Angelicae Sinensis 45, Fructus Crataegi 75, Pericarpium Citri Reticulatae 25, Radix Glycyrrhizae 32.
5. the medicine of prevention as claimed in claim 1 and treatment postpartum disease of cow is characterized in that adopting the crude drug of following composition by weight to constitute: Herba Leonuri 105, Semen Vaccariae 55, Flos Carthami 50, Rhizoma Chuanxiong 40, the Radix Paeoniae Alba 40, Radix Rehmanniae Preparata 55, Radix Codonopsis 35, Radix Angelicae Sinensis 35, Fructus Crataegi 87, Pericarpium Citri Reticulatae 35, Radix Glycyrrhizae 38.
6. as the medicine of described prevention of claim 1～5 and treatment postpartum disease of cow, it is characterized in that: according to common process, roguing, dedusting, pulverizing, mixing are made powder or water preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100549822A CN101143177B (en) | 2007-08-16 | 2007-08-16 | Medicine for preventing and treating postpartum disease of cow |
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| CN2007100549822A CN101143177B (en) | 2007-08-16 | 2007-08-16 | Medicine for preventing and treating postpartum disease of cow |
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| CN101143177B CN101143177B (en) | 2010-06-23 |
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| CN101732580B (en) * | 2008-11-12 | 2011-04-06 | 赵占伟 | Chinese medicinal herb preparation for lactation stimulation of livestock |
| CN101569697B (en) * | 2009-06-12 | 2011-10-26 | 河北科星药业有限公司 | Chinese traditional medicine for treating postpartum retained afterbirth of female animals |
| CN102579739A (en) * | 2012-03-06 | 2012-07-18 | 康莉 | Chinese medicinal composition for treating postpartum lochiorrhagia of dairy cattle |
| CN102960298A (en) * | 2012-11-23 | 2013-03-13 | 江西省大富乳业集团有限公司 | Breeding method for improving yield and quality of milk of cows in mountain areas of south China |
| CN103340979A (en) * | 2013-07-25 | 2013-10-09 | 天津集合科技有限公司 | Chinese herbal medicine composition for treating canine postpartum inappetence and preparation method thereof |
| CN103859234A (en) * | 2014-03-31 | 2014-06-18 | 福建漳州绿野农业开发有限公司 | Medicated food nutrient conditioner for improving health of sow and piglets in suckling period and preparation method and application thereof |
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| CN104706805A (en) * | 2015-03-31 | 2015-06-17 | 甘肃省动物疫病预防控制中心 | Traditional Chinese medicine for treating postpartum retained fetal membranes of cows |
| CN105056160A (en) * | 2015-09-25 | 2015-11-18 | 山东新希望六和集团有限公司 | Medicine composition for treating agalactia of cows and preparation method thereof |
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- 2007-08-16 CN CN2007100549822A patent/CN101143177B/en not_active Expired - Fee Related
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| CN101732580B (en) * | 2008-11-12 | 2011-04-06 | 赵占伟 | Chinese medicinal herb preparation for lactation stimulation of livestock |
| CN101569697B (en) * | 2009-06-12 | 2011-10-26 | 河北科星药业有限公司 | Chinese traditional medicine for treating postpartum retained afterbirth of female animals |
| CN102579739A (en) * | 2012-03-06 | 2012-07-18 | 康莉 | Chinese medicinal composition for treating postpartum lochiorrhagia of dairy cattle |
| CN102579739B (en) * | 2012-03-06 | 2013-07-17 | 康莉 | Chinese medicinal composition for treating postpartum lochiorrhagia of dairy cattle |
| CN102960298A (en) * | 2012-11-23 | 2013-03-13 | 江西省大富乳业集团有限公司 | Breeding method for improving yield and quality of milk of cows in mountain areas of south China |
| CN103340979A (en) * | 2013-07-25 | 2013-10-09 | 天津集合科技有限公司 | Chinese herbal medicine composition for treating canine postpartum inappetence and preparation method thereof |
| CN103859234A (en) * | 2014-03-31 | 2014-06-18 | 福建漳州绿野农业开发有限公司 | Medicated food nutrient conditioner for improving health of sow and piglets in suckling period and preparation method and application thereof |
| CN103859234B (en) * | 2014-03-31 | 2015-10-07 | 福建漳州绿野农业开发股份有限公司 | Improve herbal cuisine nutrition recuperating agent of female piglet health lactation and its preparation method and application |
| CN104189344A (en) * | 2014-09-05 | 2014-12-10 | 江苏农林职业技术学院 | Traditional Chinese medicine composition for promoting postpartum reproductive function resumption of dairy cows and preparation method of traditional Chinese medicine composition |
| CN104706805A (en) * | 2015-03-31 | 2015-06-17 | 甘肃省动物疫病预防控制中心 | Traditional Chinese medicine for treating postpartum retained fetal membranes of cows |
| CN105056160A (en) * | 2015-09-25 | 2015-11-18 | 山东新希望六和集团有限公司 | Medicine composition for treating agalactia of cows and preparation method thereof |
| CN105288082A (en) * | 2015-12-01 | 2016-02-03 | 蓬溪发联农牧有限公司 | Pharmaceutical composition for curing mother rabbit hypogalactia as well as preparation method and application thereof |
| CN107669934A (en) * | 2017-11-14 | 2018-02-09 | 河北省畜牧兽医研究所 | Compound preparation of milk cow retained afterbirth and postpartum health care and preparation method thereof, application method are prevented and treated for colony |
| CN107669934B (en) * | 2017-11-14 | 2020-08-07 | 河北省畜牧兽医研究所 | Compound preparation for preventing and treating retained afterbirth and postpartum health care of dairy cows in groups and preparation method thereof |
| CN116098938A (en) * | 2022-12-30 | 2023-05-12 | 安徽科技学院 | Treatment method for improving milk cow reproduction rate and milk yield by adopting Chinese herbal medicine preparation and application |
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| CN101143177B (en) | 2010-06-23 |
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