CN106038820A - Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof - Google Patents
Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof Download PDFInfo
- Publication number
- CN106038820A CN106038820A CN201610506381.XA CN201610506381A CN106038820A CN 106038820 A CN106038820 A CN 106038820A CN 201610506381 A CN201610506381 A CN 201610506381A CN 106038820 A CN106038820 A CN 106038820A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- constipation
- medicine composition
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 105
- 206010010774 Constipation Diseases 0.000 title claims abstract description 62
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims description 23
- 241000628997 Flos Species 0.000 claims abstract description 17
- 239000010135 fructus aurantii immaturus Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 15
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940079593 drug Drugs 0.000 claims description 42
- 235000013305 food Nutrition 0.000 claims description 34
- 210000000582 semen Anatomy 0.000 claims description 29
- 241000218236 Cannabis Species 0.000 claims description 17
- 239000000047 product Substances 0.000 claims description 14
- 230000036541 health Effects 0.000 claims description 11
- 239000004615 ingredient Substances 0.000 claims description 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 235000013376 functional food Nutrition 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 2
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229960003121 arginine Drugs 0.000 claims description 2
- 235000009697 arginine Nutrition 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- 229940119170 jojoba wax Drugs 0.000 claims description 2
- 229940057910 shea butter Drugs 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 229940074410 trehalose Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 210000004185 liver Anatomy 0.000 abstract description 15
- 210000003734 kidney Anatomy 0.000 abstract description 13
- 210000000936 intestine Anatomy 0.000 abstract description 10
- 208000024891 symptom Diseases 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 244000241872 Lycium chinense Species 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 244000018633 Prunus armeniaca Species 0.000 abstract 1
- 235000009827 Prunus armeniaca Nutrition 0.000 abstract 1
- 235000007215 black sesame Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000009499 grossing Methods 0.000 abstract 1
- 240000004308 marijuana Species 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 16
- 241000699670 Mus sp. Species 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- 230000013872 defecation Effects 0.000 description 13
- 239000003610 charcoal Substances 0.000 description 11
- 230000000968 intestinal effect Effects 0.000 description 10
- 210000000952 spleen Anatomy 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 208000019790 abdominal distention Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000002173 dizziness Diseases 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 210000003608 fece Anatomy 0.000 description 5
- 238000003304 gavage Methods 0.000 description 5
- 210000002429 large intestine Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 206010003549 asthenia Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 230000002787 reinforcement Effects 0.000 description 4
- 235000019640 taste Nutrition 0.000 description 4
- 206010000077 Abdominal mass Diseases 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 3
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 208000025747 Rheumatic disease Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 231100000540 amenorrhea Toxicity 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 239000008141 laxative Substances 0.000 description 3
- 230000002475 laxative effect Effects 0.000 description 3
- 210000001809 melena Anatomy 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000000552 rheumatic effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000030136 gastric emptying Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 235000014593 oils and fats Nutrition 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 206010021033 Hypomenorrhoea Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 208000036471 Melanosis coli Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000009257 Visceral Prolapse Diseases 0.000 description 1
- 206010063840 Visceroptosis Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- -1 compound diphenoxylate Chemical class 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 229960004192 diphenoxylate Drugs 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000003814 hair luster Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000023513 hiccough Diseases 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses an edible and medicinal traditional Chinese medicine composition for improving functional constipation. The composition is prepared from the following raw materials in parts by weight: 10-20 parts of fructus cannabis, 25-35 parts of radix paeoniae alba, 6-12 parts of fructus aurantii immaturus, 6-12 parts of flos magnolisa officinalis, 6-12 parts of apricot kernels, 15-25 parts of angelica sinensis, 15-25 parts of black sesame, 10-20 parts of Chinese wolfberry fruits, 10-20 parts of radix cyathulae and 3-9 parts of licorice roots. In the edible and medicinal traditional Chinese medicine composition, the raw materials are edible and medicinal traditional Chinese medicinal raw materials, have small toxic and side effects, are safe to use, are reasonably combined and scientific in compatibility and are combined to achieve the effects of smoothing intestine, relieving constipation, nourishing yin, moistening dryness, nourishing liver and kidneys, and have a remarkable synergistic effect, so that mutual promotion and mutual enhancement relationship can be sufficiently achieved. The traditional Chinese medicine composition can be used for effectively improving the symptom of constipation, is safe, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of compositions improving functional constipation Medicine Food Homology Chinese medicine and preparation method thereof.
Background technology
Functional constipation is clinical common intestinal illness, and Epidemiological study shows, China's chronic functional constipation is suffered from
Sick rate is in ascendant trend year by year, and 10, Beijing area hospital 16～72923 person-times of Digestive System Department out-patients of 87 years old crowd are carried out
Questionnaire survey shows, chronic functional constipation patient totally 3009 examples time, prevalence is 4.1%.Clinical manifestation is that defecation frequency subtracts
Less, feces amount reduces, feces is dry and hard, defecation is laborious, the course of disease at least 6 months.Along with the prolongation of the course of disease, a lot of patients often accompany
The feelings will such as spiritedness anxiety, anxiety change, and become the key factor affecting patient work and life, produce huge to patient's body and mind
Impact.
The traditional Chinese medical science is thought, the generation of constipation, mainly due to deficiency of the spleen causing weakness of QI, or depression of liver-QI, or gastrointestinal accumulated heat, make taste transport
Changing disorder, intestinal internal organs is along fall hypofunction, and the waste matter affecting large intestine phoresys excretion.Intestinal disorder of movement of QI, conduction function are not normal
And form constipation.
For the treatment of constipation, doctor trained in Western medicine is based on symptomatic treatment, it is intended to eliminates the symptom of constipation, makes patient's defecation unobstructed,
The most secondary increase, feces is prone to discharge.Conventional laxative has osmotic laxative, osmotic laxative treatments, dripping of irritant drugs and motivator
Agent etc., but said medicine treatment existence causes abdominal distention, intestinal obstruction, melanosis coli, cardiovascular complication, electrolyte disturbance, kidney
The risk of the side effect such as functional lesion.
Chinese medicine constipation has long history, and document is recorded and long-term clinical practice also indicates that Chinese medicine is anti-
The aspect that treats constipation has obvious positive role.But the product mesh improving functional constipation being prepared from by Medicine Food Homology Chinese medicine
Before commercially or blank, the highest attention to health care along with Chinese society living-pattern preservation and the people, and
Country is flourish to the attention of health industry and the Chinese medicine that is good at dialectical diagnosis and treatment, it is necessary to exploitation meets clinical
Property demand, improve the new product of constipation.
Summary of the invention
It is an object of the invention to provide a kind of Medicine Food Homology Chinese medicine composition improving functional constipation, by 10 tastes " food medicine
Homology " Chinese medicine be prepared from as raw material, this Medicine Food Homology Chinese medicine composition has loosening bowel to relieve constipation, and heat clearing away is except stagnant, and YIN nourishing is supported
Blood, effect of invigorating the liver and kidney of holding concurrently, it is possible to be effectively improved constipation symptom, and safe without toxic side effect.
It is a further object of the present invention to provide the preparation method of said composition, this preparation method can realize industry metaplasia
Produce.
For achieving the above object, the present invention uses following technical proposals:
First aspect present invention, it is provided that a kind of Medicine Food Homology Chinese medicine composition improving functional constipation, its raw material forms
For:
Fructus Cannabis 10-20 part, Radix Paeoniae Alba 25-35 part, Fructus Aurantii Immaturus 6-12 part, Flos Magnoliae Officinalis 6-12 part, Semen Armeniacae Amarum 6-12 part, Radix Angelicae Sinensis 15-
25 parts, Semen Sesami Nigrum 15-25 part, Fructus Lycii 10-20 part, Radix Cyathulae 10-20 part, Radix Glycyrrhizae 3-9 part.
The Medicine Food Homology Chinese medicine composition improving functional constipation of the present invention, preferred prescription is:
Fructus Cannabis 15 parts, the Radix Paeoniae Alba 30 parts, Fructus Aurantii Immaturus 9 parts, Flos Magnoliae Officinalis 9 parts, 9 parts of Semen Armeniacae Amarum, Radix Angelicae Sinensis 20 parts, Semen Sesami Nigrum 20 parts, Chinese holly
Qi 15 parts, Radix Cyathulae 15 parts, 6 parts of Radix Glycyrrhizae.
The compatibility of Chinese medicine be particular about mutual reinforcement between, make mutually, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition is conversely, because exist not between different Chinese medicine
Same compatibility relationship, therefore when using the two above Chinese medicine of taste, it is necessary to be allowed a choice, give full play to what mutual reinforcement between medicine made mutually
Compatibility relationship, makes the clinical effectiveness of product be significantly improved.
On the other hand, Chinese medicine ingredients is complicated, existing water soluble ingredient in a kind of medical material, has again oil-soluble or alcohol-soluble to become
Divide, and some active component the most easily inactivates, therefore by selecting suitable extracting method and extraction process to Chinese medicine
Effective ingredient carries out extracting separation, to extract effective ingredient to greatest extent and to ensure the activity of effective ingredient, thus ensures
The clinical effectiveness of product.
The present invention, by the extract of kinds of traditional Chinese medicines is carried out compatibility, has played loosening bowel to relieve constipation, heat clearing away jointly between medicine
Except stagnant, nourishing YIN and benefiting blood, the effect of invigorating the liver and kidney of holding concurrently, there is obvious potentiation, given full play to the compatibility relationship that mutual reinforcement between makes mutually.
In compositions, the pharmacology analysis of each component is as follows:
Fructus Cannabis: sweet is flat.Return spleen, stomach, large intestine channel.Loosening bowel to relieve constipation.For blood deficiency and depleted fluid, dryness of the intestine constipation.
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Return liver, spleen channel.Function nourishes blood yin fluid astringing, easing the affected liver to relieve pain, suppressing liver-YANG.It is mainly used to menstruation not
Adjust, metrorrhagia, sweating due to debility, gastral cavity abdomen shoot, the pain over the hypochondriac region, limb pain twin, dizziness of having a headache.Reuse the effect of cathartic.
Fructus Aurantii Immaturus: bitter, pungent, sour, is slightly cold.Return spleen, stomach warp.Dispelling the stagnated QI removing food stagnancy, scattered painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain,
Weight, constipation, the stagnant vapour lock of expectorant, the thoracic obstruction, blocked-up chest, visceroptosis after dysentery.
Flos Magnoliae Officinalis: bitter, pungent, temperature.Return spleen, stomach, lung, large intestine channel.Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass
Vomiting and diarrhoea, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Semen Armeniacae Amarum: bitter, tepor.Return lung, large intestine channel.This product is matter profit containing oils and fats, bitter in the mouth and the therapeutic method to keep the adverse QI flowing downwards, thus can loosening bowel to relieve constipation, use
In dryness of the intestine constipation.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy
Dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine)
Promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Semen Sesami Nigrum: sweet, flat.Return liver, kidney, large intestine channel.Invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For blood and essence asthenia, dizzy eye
Flower, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.
Fructus Lycii: sweet, flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, dizziness ear
Ring, impotence and seminal emission, interior-heat quenches one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix Cyathulae: hardship sweet, micro-, flat.Return liver, kidney channel.Eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea abdominal mass,
Retention of placenta, injury from falling down, rheumatic arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, it is in harmonious proportion all
Medicine.For weakness of the spleen and stomach, all diseases of fatigue and weakness.
In the Medicine Food Homology Chinese medicine composition of the present invention, Fructus Cannabis compatibility when be classified as monarch drug, function enriching blood for moistening the intestine relieving constipation, in vain
Chinese herbaceous peony compatibility Semen Sesami Nigrum, blood enriching and dryness moistening, YIN nourishing relieving constipation, assistant is with Fructus Aurantii Immaturus, Flos Magnoliae Officinalis, and the therapeutic method to keep the adverse QI flowing downwards leads to stagnant de-swelling, and Semen Armeniacae Amarum opens lung qi dispersing gas, intestine moistening
Relieving constipation, Fructus Lycii nourishing YIN and supplementing blood liver and kidney tonifying, Radix Cyathulae invigorating the liver and kidney, conducting blood to flow downwards, Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription.All medicines share, and play profit altogether
Intestinal relieving constipation, nourishing YIN to relieve dryness, effect of nourishing the liver and kidney.
In the Medicine Food Homology Chinese medicine composition of the present invention, each raw material components is an organic whole, indispensable.Invention
People finds in R&D process, reduces or replace any one of above-mentioned composition raw material components, the then work that compositions is overall
Significantly reduce by effect；Other raw material components it is further added by, the whole structure of compositions on the basis of the compositions of the present invention
Not improving significantly, the situation even having the whole structure of compositions to reduce occurs.
Above-mentioned Medicine Food Homology Chinese medicine composition can use after mix homogeneously directly by each raw material pulverizing；Or boiling；Also
Can prepare according to additive method.In a specific embodiment of the present invention, the system of above-mentioned Medicine Food Homology Chinese medicine composition
Preparation Method is:
(1) by Fructus Cannabis, Fructus Aurantii Immaturus, Flos Magnoliae Officinalis, Radix Angelicae Sinensis, Fructus Lycii, Radix Cyathulae, Radix Glycyrrhizae mixing, boiling twice, filter
(add 8 times amount water for the first time, decoct 2 hours；Second time adds 6 times amount water, decocts 1.5 hours), merging filtrate, it is concentrated into the closeest
Degree is the extractum of 1.2 (50 DEG C)；
(2) by the Radix Paeoniae Alba, Semen Sesami Nigrum and Semen Armeniacae Amarum, pulverize, cross 100 mesh sieves, then mix with Chinese medical concrete, to obtain final product.
Above-mentioned Medicine Food Homology Chinese medicine composition is treated the pharmaceutical preparation of constipation in preparation or improves the health care of constipation in preparation
Application in product or food of special nutrients is also the scope of protection of the invention.
Second aspect present invention, it is provided that a kind of pharmaceutical preparation treating constipation, by above-mentioned Medicine Food Homology Chinese medicine composition and
Pharmaceutically acceptable adjuvant is prepared from.
Said medicine preparation can make various pharmaceutical dosage form, such as gel, spray, lotion, emulsifiable paste/cream, powder
Deng.
Described pharmaceutically acceptable adjuvant is the customary adjuvant in pharmaceutical preparation, preferably glycerol, butanediol, Sargassum
One or more in sugar, glycine betaine, allantoin, carbomer, arginine, shea butter, Jojoba oil, emulsifying agent.
A third aspect of the present invention, it is provided that a kind of health product improving constipation, with above-mentioned Medicine Food Homology Chinese medicine composition be
Effective ingredient.
A fourth aspect of the present invention, it is provided that a kind of special medicine purposes functional food improving constipation, same with above-mentioned food medicine
Source Chinese medicine composition is effective ingredient.
Beneficial effects of the present invention:
In the compositions of the present invention, selected crude drug is the Chinese medicine of Medicine Food Homology or can be used in health product
Medicine, has no side effect, and uses safer；Each raw material reasonable recipe, compatibility science, jointly play intestine moistening between medicine and led to
Just, nourishing YIN to relieve dryness, the effect of nourishing the liver and kidney, there is obvious potentiation, given full play to the compatibility relationship that mutual reinforcement between makes mutually.
Using the compositions of the present invention as effective ingredient, can be prepared as the pharmaceutical preparation for treating or improve constipation,
The product of the multiple multi-forms such as health product and special medicine purposes functional food, products application is various informative.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, it should explanation, the description below be only for
The explanation present invention, is not defined its content.
Embodiment 1: improve the preparation of the Medicine Food Homology Chinese medicine composition of functional constipation
Formula: Fructus Cannabis 15 grams, the Radix Paeoniae Alba 30 grams, Fructus Aurantii Immaturus 9 grams, Flos Magnoliae Officinalis 9 grams, 9 grams of Semen Armeniacae Amarum, Radix Angelicae Sinensis 20 grams, Semen Sesami Nigrum 20
Gram, Fructus Lycii 15 grams, Radix Cyathulae 15 grams, 6 grams of Radix Glycyrrhizae.
Preparation method:
(1) by Fructus Cannabis, Fructus Aurantii Immaturus, Flos Magnoliae Officinalis, Radix Angelicae Sinensis, Fructus Lycii, Radix Cyathulae, Radix Glycyrrhizae mixing, boiling twice, filter
(add 8 times amount water for the first time, decoct 2 hours；Second time adds 6 times amount water, decocts 1.5 hours), merging filtrate, it is concentrated into the closeest
Degree is the extractum of 1.2 (50 DEG C)；
(2) by the Radix Paeoniae Alba, Semen Sesami Nigrum and Semen Armeniacae Amarum, pulverize, cross 100 mesh sieves, then mix with Chinese medical concrete, to obtain final product.
Embodiment 2: improve the Medicine Food Homology Chinese medicine composition of functional constipation
Formula: Fructus Cannabis 10 grams, the Radix Paeoniae Alba 35 grams, Fructus Aurantii Immaturus 6 grams, Flos Magnoliae Officinalis 12 grams, 6 grams of Semen Armeniacae Amarum, Radix Angelicae Sinensis 25 grams, Semen Sesami Nigrum 15
Gram, Fructus Lycii 20 grams, Radix Cyathulae 10 grams, 9 grams of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3: improve the Medicine Food Homology Chinese medicine composition of functional constipation
Formula: Fructus Cannabis 20 grams, the Radix Paeoniae Alba 25 grams, Fructus Aurantii Immaturus 12 grams, Flos Magnoliae Officinalis 6 grams, 12 grams of Semen Armeniacae Amarum, Radix Angelicae Sinensis 15 grams, Semen Sesami Nigrum
25 grams, Fructus Lycii 10 grams, Radix Cyathulae 20 grams, 3 grams of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4: improve the preparation of the Medicine Food Homology Chinese medicine composition of functional constipation
Formula: Fructus Cannabis 15 grams, the Radix Paeoniae Alba 30 grams, Fructus Aurantii Immaturus 9 grams, Flos Magnoliae Officinalis 9 grams, 9 grams of Semen Armeniacae Amarum, Radix Angelicae Sinensis 20 grams, Semen Sesami Nigrum 20
Gram, Fructus Lycii 15 grams, Radix Cyathulae 15 grams, 6 grams of Radix Glycyrrhizae.
Preparation method: add water common decoction by above-mentioned raw materials medicine, makes decoction.
Embodiment 5: improve the health product of functional constipation
Formula, Fructus Cannabis 15 grams, the Radix Paeoniae Alba 30 grams, Fructus Aurantii Immaturus 9 grams, Flos Magnoliae Officinalis 9 grams, Semen Armeniacae Amarum is carried out by following raw materials according and consumption thereof
9 grams, Radix Angelicae Sinensis 20 grams, Semen Sesami Nigrum 20 grams, Fructus Lycii 15 grams, Radix Cyathulae 15 grams, 6 grams of Radix Glycyrrhizae, be prepared as improving the food of functional constipation
Medicine homology Chinese medicine composition, preparation method is with embodiment 1.Add sweeting agent or walnut powder is made quickly, instant food just
Carrying in going out edible, if making beverage, adding adjuvant less, being distributed into 10-65ml/ bottle, every day is early, middle and late 0.5 little after meal
Time respectively drink 1 bottle.
Embodiment 6: improve the special medicine purposes functional food of functional constipation
Formula, Fructus Cannabis 15 grams, the Radix Paeoniae Alba 30 grams, Fructus Aurantii Immaturus 9 grams, Flos Magnoliae Officinalis 9 grams, Semen Armeniacae Amarum is carried out by following raw materials according and consumption thereof
9 grams, Radix Angelicae Sinensis 20 grams, Semen Sesami Nigrum 20 grams, Fructus Lycii 15 grams, Radix Cyathulae 15 grams, 6 grams of Radix Glycyrrhizae, then add multiple probiotic bacteria 300g, small peptide
200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, there are the grease 100g of health care, vitamin
A0.01g, vitamin D 0.00001 5g.
It is prepared as improving the Medicine Food Homology Chinese medicine composition of functional constipation as described in Example 1, then adds small peptide, benefit
Give birth to unit, aminoacid, carbohydrate, have the oils and fats of health care, multivitamin to carry out pasteurization 1 after being pulverized and mixed together
Hour, then add the bacillus bifidus after micro encapsulation, the lactobacillus after micro encapsulation, the streptococcus thermophilus after micro encapsulation also
Mix homogeneously makes the solid beverage of powdery, granule, and is distributed into 10g/ bag, after dissolving by about 150ml warm water, directly drinks
With or through nasal feeding take in；Or add appropriate amount of auxiliary materials make capsule, tablet etc..
Comparative example 1:
The present inventor in R&D process, the multi-flavor crude drug with the close property of medicine has been carried out compatibility relationship investigation and
The research of drug effect, even if it was found that the property of medicine between a few taste crude drug is similar, but the crude drug compatibility different from other makes
With rear, its effect significant difference.Such as: by the pharmaceutical formulation of embodiment 1 has effect of relaxing bowel Fructus Cannabis and
Radix Angelicae Sinensis replaces with Radix Et Rhizoma Rhei and the Radix Polygoni Multiflori with similar effect；Prepare by the preparation method of embodiment 1.
Animal experiment shows, the compositions of the embodiment of the present invention 1 preparation to show for the therapeutic effect of Constipated mice
Work is better than comparative example 1.Illustrate that the compositions of the present invention meets the compatibility relationship of Chinese medicine, there is between each component collaborative promotion and make
With, it is not that the simple of crude drug with the similar property of medicine is replaced and combination.
Animal experiment:
1. animal packet and model copy:
Cleaning grade Kunming mouse, male, 40, body weight 18-22g, it is purchased from Jinan friend and pleases laboratory animal and breed limited public affairs
Department, the quality certification number: 37009200002908.Animal adaptability was raised after 7 days, with random digits table be randomly divided into normal group,
Model group, model administration group, normally administration group, totally 4 groups, often group 10.
Mice self feces is ground by reference literature method a little, adds normal saline and makes the suspension of 0.lg/L, presses
ImL/ every day gavage give 1 time, for three days on end；In the 5-7 days, every day with compound diphenoxylate solution (2mg/kg) gavage,
0.3mL/ only, for three days on end, is administered and modeling interval 30min, replicates Constipation Model.
2. medicine preparation and administration
Model administration group and normal administration group use the compositions of embodiment 1 preparation, ask according to people's per weight crude drug amount
Obtain mouse unit body weight crude drug amount, and expand 20 times, i.e. 12g/kg.
Model administration group be normally administered treated animal, every day 1 gastric infusion, 0.3mL/ only, continuous 7 days；Normal group and
Model group gives equivalent distilled water gavage.Each group in last be administered after, fasting 12h put to death.
3. detection project
3.1 ordinary circumstance
Observe the mobility of mice, mental status, hair luster degree and diet situation etc..
3.2 defecation laboratory observations
Be administered in the 7th day and terminate rear 30min, give 5% carbon suspensioning liquid that each treated animal prepared (5% charcoal end with
10% Radix Acaciae senegalis), every 0.2mL, mice is put into the mouse cage being covered with filter paper, every cage puts mice 1, and normal supply
Word material and drinking-water, start simultaneously at accurate timing.Observed and recorded every mice is discharged the time containing powdered carbon melena feces first, continuously
Observe 4h, mice total defecation grain number in record 4h, and weigh.
3.3 small intestinal charcoal end propelling rates
Detect each group after last is administered, fasting 12h, with 5% carbon suspensioning liquid (5% charcoal end with 10% Radix Acaciae senegalis)
Gavage, every 0.2mL, take off neck after 25nin immediately and push away execution animal, open rapidly abdominal cavity, separate small intestinal, clip upper end is from deep and remote
Door, the intestinal tube of lower end to ileocecus, be placed on pallet, paved by small intestinal gently and be in line, not tractive.It is little for measuring Length of intestine
Intestinal total length, from pylorus to forward position, charcoal end be charcoal end advance length, by formula calculate charcoal end propelling rate (charcoal end propelling rate (%)=
Charcoal end advances length+total small intestinal length X100%).
3.4 gastric emptying rate
Mice 2%DB-2000 gavage, 0.4ml/ only, surveys absorbance, gastric emptying rate at spectrophotometer 620nm
(%)=1-A1/A2 (A1: gastric DB-2000 absorbance, A2: benchmark DB-2000 absorbance)
4. result
4.1 ordinary circumstance
Normal group mice is fat, spiritual well, action is active, diet does not subtracts, fur is moistened.Model group mice sees fur color
Pool is matt, the perpendicular hair of jaundice companion, curls and squats, movable reduces, and lethargy, poor appetite, feces quality is hard, is dried.Medicine is done
The above-mentioned change of mice of pre-group has alleviated.
4.2 defecation experimental observations
Compared with normal group, model group little mouse's head grain melena time lengthening, 4h defecation grain number, 4h defecation weight substantially subtract
Few, difference has significant meaning (P < 0.05 or P < 0.01).Compared with model group, the model administration group first grain melena time shortens, 4h
Defecation grain number, 4h defecation weight increase (P < 0.05).It is shown in Table 1
Table 1 is respectively organized mice defecation situation and is compared (n=8, x ± s)
Note: with normal group ratio,*P < 0.05,**P<0.01；With model group ratio,#P < 0.05,##P<0.01
4.3 gastroenteritic power functions are observed
Model group mouse small intestine charcoal end propelling rate reduce, with normal group comparing difference have significant meaning ((P < 0.05 or P <
0.01) model administration group mouse small intestine charcoal end propelling rate raises, and compares with model group and has significant difference (P < 0.05 or P < 0.01),
Prompting can strengthen mice with constipation gastrointestinal motility ability, alleviates that motor function is limited and dysporia.Normal group and normal administration group
Mice in terms of small intestinal charcoal end propelling rate difference without significant property.It is shown in Table 2.
Table 2 is respectively organized the gastrointestinal function of mice and is compared (n=8, x ± s)
Note: with normal group ratio,*P < 0.05,**P<0.01；With model group ratio,#P < 0.05,##P<0.01
Model case:
Certain patient, female, 16 years old, student, goes to a doctor on May 2nd, 2015.Constipation, abdominal distention after meal more than 1 year.Patient defecates 3～4
Day a line, difficult defecation, amount is few the most micro-dry.Abdominal distention after meal, the most weak, facial multiple acne, time send out oral ulcer.Usually because of study
Anxiety, has LA emotion.Receive can, sleep poor, urine adjust.Hypomenorrhea, light through color, menostaxis.Light red tongue, white, slippery and moist fur, arteries and veins
Weak.On April 10th, 2015 is at certain examination in hospital all-digestive tract barium meal no abnormality seen.Tcm diagnosis: constipation (hematasthenic constipation).Work as YIN nourishing
Nourish blood, loosening bowel to relieve constipation.Prescription: Fructus Cannabis 15g, Radix Paeoniae Alba 30g, Fructus Aurantii Immaturus 9g, Flos Magnoliae Officinalis 9g, Semen Armeniacae Amarum 9g, Radix Angelicae Sinensis 20g, Semen Sesami Nigrum
20g, Fructus Lycii 15g, Radix Cyathulae 15g, Radix Glycyrrhizae 6g.Medicine-feeding decocting, sub-service sooner or later altogether.After after 6 days, during further consultation, patient tells and takes two doses
Defecating l time, abdominal distention substantially alleviates.After taking 4 doses, defecating again 1 time, the breast side of body, distension and fullness in the abdomen disappear substantially.Defence's following the service 14 doses,
Defecating every day 1 time, the softest smooth profit, all diseases eliminate.Advise it to regulate daily life, the veterinary antibiotics of many feed rich cellulose and
Corn, suitably increases activity, forms the custom of timing defecation.Follow up a case by regular visits to not recur.
Claims (10)
1. the Medicine Food Homology Chinese medicine composition improving functional constipation, it is characterised in that its raw material consists of:
Fructus Cannabis 10-20 part, Radix Paeoniae Alba 25-35 part, Fructus Aurantii Immaturus 6-12 part, Flos Magnoliae Officinalis 6-12 part, Semen Armeniacae Amarum 6-12 part, Radix Angelicae Sinensis 15-25 part,
Semen Sesami Nigrum 15-25 part, Fructus Lycii 10-20 part, Radix Cyathulae 10-20 part, Radix Glycyrrhizae 3-9 part.
2. Medicine Food Homology Chinese medicine composition as claimed in claim 1, it is characterised in that its raw material consists of:
Fructus Cannabis 15 parts, the Radix Paeoniae Alba 30 parts, Fructus Aurantii Immaturus 9 parts, Flos Magnoliae Officinalis 9 parts, 9 parts of Semen Armeniacae Amarum, Radix Angelicae Sinensis 20 parts, Semen Sesami Nigrum 20 parts, Fructus Lycii 15
Part, Radix Cyathulae 15 parts, 6 parts of Radix Glycyrrhizae.
3. the preparation method of the Medicine Food Homology Chinese medicine composition described in claim 1 or 2, it is characterised in that step is as follows:
By Fructus Cannabis, Fructus Aurantii Immaturus, Flos Magnoliae Officinalis, Radix Angelicae Sinensis, Fructus Lycii, Radix Cyathulae, Radix Glycyrrhizae mixing, boiling, filter, merging filtrate, dense
It is reduced to the extractum that relative density is 1.2 (50 DEG C)；
(2) by Radix Paeoniae Alba, Semen Sesami Nigrum and Semen Armeniacae Amarum, pulverize, sieve, then mix with Chinese medical concrete powder, to obtain final product.
4. the purposes in the pharmaceutical preparation of preparation treatment constipation of the Medicine Food Homology Chinese medicine composition described in claim 1 or 2.
5. the Medicine Food Homology Chinese medicine composition described in claim 1 or 2 improves health product or the special medicine use of constipation in preparation
Purposes in functional food on the way.
6. treat a pharmaceutical preparation for constipation, by the Medicine Food Homology Chinese medicine composition described in claim 1 or 2 and pharmaceutically may be used
The adjuvant accepted is prepared from.
7. pharmaceutical preparation as claimed in claim 6, it is characterised in that described pharmaceutically acceptable adjuvant is selected from glycerol, fourth
One or many in glycol, trehalose, glycine betaine, allantoin, carbomer, arginine, shea butter, Jojoba oil, emulsifying agent
Kind.
8. pharmaceutical preparation as claimed in claim 6, it is characterised in that the dosage form of described pharmaceutical preparation be gel, capsule,
Suppository or pill.
9. the health product improving constipation, it is characterised in that with the Medicine Food Homology Chinese medicine composition described in claim 1 or 2
For effective ingredient.
10. the special medicine purposes functional food improving constipation, it is characterised in that with the food medicine described in claim 1 or 2
Homology Chinese medicine composition is effective ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610506381.XA CN106038820A (en) | 2016-06-30 | 2016-06-30 | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610506381.XA CN106038820A (en) | 2016-06-30 | 2016-06-30 | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106038820A true CN106038820A (en) | 2016-10-26 |
Family
ID=57201502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610506381.XA Pending CN106038820A (en) | 2016-06-30 | 2016-06-30 | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106038820A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260410A (en) * | 2018-03-12 | 2019-01-25 | 季旭明 | A kind of improvement functional consitipation food and medicine consangunity beverage and preparation method thereof |
| CN109620907A (en) * | 2019-01-11 | 2019-04-16 | 李笑斌 | A kind of drug and its preparation method and application for treating constipation |
| CN109833371A (en) * | 2019-04-04 | 2019-06-04 | 扬州市中医院 | A kind of Chinese medicine composition that treating post-operative hemorrhoids and anal fistula constipation and preparation method and purposes |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129613A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese parent medicine for treating constipation |
| CN101912472A (en) * | 2010-08-13 | 2010-12-15 | 黄文珍 | Chinese medicinal composition for treating habitual constipation and preparation method thereof |
| CN101953922A (en) * | 2010-08-27 | 2011-01-26 | 孔德旺 | Chinese medicinal composition for treating constipation |
| CN104337905A (en) * | 2013-08-06 | 2015-02-11 | 李杏娇 | Pill for moistening stomach and enriching blood |
| CN105535243A (en) * | 2016-02-29 | 2016-05-04 | 陈书明 | Medicine for treating intractable constipation |
-
2016
- 2016-06-30 CN CN201610506381.XA patent/CN106038820A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129613A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese parent medicine for treating constipation |
| CN101912472A (en) * | 2010-08-13 | 2010-12-15 | 黄文珍 | Chinese medicinal composition for treating habitual constipation and preparation method thereof |
| CN101953922A (en) * | 2010-08-27 | 2011-01-26 | 孔德旺 | Chinese medicinal composition for treating constipation |
| CN104337905A (en) * | 2013-08-06 | 2015-02-11 | 李杏娇 | Pill for moistening stomach and enriching blood |
| CN105535243A (en) * | 2016-02-29 | 2016-05-04 | 陈书明 | Medicine for treating intractable constipation |
Non-Patent Citations (3)
| Title |
|---|
| 王苏丽等: "《药食两用中药实用鉴别技术》", 30 June 2013, 山东人民出版社 * |
| 郑其进等: "《肝炎良效验方精选》", 31 December 1996, 广州出版社 * |
| 陈长勋: "《中药药理学（第2版）》", 31 January 2015, 上海科学技术出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260410A (en) * | 2018-03-12 | 2019-01-25 | 季旭明 | A kind of improvement functional consitipation food and medicine consangunity beverage and preparation method thereof |
| CN109620907A (en) * | 2019-01-11 | 2019-04-16 | 李笑斌 | A kind of drug and its preparation method and application for treating constipation |
| CN109833371A (en) * | 2019-04-04 | 2019-06-04 | 扬州市中医院 | A kind of Chinese medicine composition that treating post-operative hemorrhoids and anal fistula constipation and preparation method and purposes |
| CN109833371B (en) * | 2019-04-04 | 2021-08-27 | 扬州市中医院 | Traditional Chinese medicine composition for treating constipation after hemorrhoids and fistula operation and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN101732683A (en) | Chinese medicinal preparation for treating facial chloasma and preparation method thereof | |
| CN103690919B (en) | Medicine being used for the treatment of piglet iron-deficiency anemia and preparation method thereof | |
| CN101249235B (en) | Chinese medicine for curing esophagus cancer and method of preparing the same | |
| CN104922550A (en) | Traditional Chinese medicine combination and application thereof | |
| CN104857418A (en) | Spleen tonifying and appetizing medical composition and preparation method and application thereof | |
| CN104288644A (en) | Pharmaceutical composition for treating spleen deficiency and preparation method thereof | |
| CN106038820A (en) | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof | |
| CN101085328A (en) | Oral administration traditional Chinese medicine composition for curing chronic gastritis | |
| KR20160000695A (en) | Herbal-medicine containing dha for recovering fatigue and enhancing memory, and method of manufacturing the same | |
| CN102743442B (en) | Traditional Chinese medicine composition for improving gastrointestinal function and preparation method thereof | |
| CN102552537B (en) | Chinese medicinal composition for treating qi and blood loss | |
| CN104958636A (en) | Medicinal composition for treating functional dyspepsia and preparation method of medicinal composition | |
| CN104645294B (en) | It is a kind of to treat Chinese medicine composition of baby diarrhea and its preparation method and application | |
| CN103040975B (en) | Traditional Chinese medicine composition for nursing and treating infantile diarrhea | |
| CN102526211B (en) | Composition of oral medicine for treating constipation and preparation technology | |
| CN102805834A (en) | Drug for curing gastritis and preparation method thereof | |
| CN105412424A (en) | Pharmaceutical preparation containing argy wormwood leaves and having bowel relaxing function as well as preparation method of pharmaceutical preparation | |
| CN104984237A (en) | Traditional Chinese medicine composition and preparation method | |
| CN104888132A (en) | Traditional Chinese medicine composition for treatment of chronic gastritis | |
| CN104548021A (en) | Traditional Chinese medicine composition for assisting rehabilitation after chemoradiotherapy of cancer patients | |
| CN108714182A (en) | Bowel relaxing oral liquid and preparation method | |
| CN108771658A (en) | A kind of bowel relaxing oral liquid and preparation method | |
| CN109260410A (en) | A kind of improvement functional consitipation food and medicine consangunity beverage and preparation method thereof | |
| CN101229331B (en) | Medicine for treating anorexia, limosis and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161026 |
|
| RJ01 | Rejection of invention patent application after publication |