CN104548021A - Traditional Chinese medicine composition for assisting rehabilitation after chemoradiotherapy of cancer patients - Google Patents

Abstract

The invention aims to overcome defects in the prior art and adverse reaction caused by western medicine after chemoradiotherapy of cancer patients, and provides a traditional Chinese medicine composition for assisting rehabilitation after the chemoradiotherapy of cancer patients. The traditional Chinese medicine composition is prepared by repeated verification of clinical tests, and conforms to the traditional Chinese medicine theory. According to the traditional Chinese medicine composition, hedyotis diffusa, Chinese actinidia root, cicca arietina, aspongopus and trigone are used as monarch drugs to resist cancer and inhibit tumor diffusion and deterioration; liriope spicata, rhizoma kaempferiae, Chinese hawthorn leaf, radix polygonati officinalis, rice sprout and hippophae rhamnoides are used as ministerial drugs to nourish yin, generate body fluid, promote qi, warm middle, promote gastric digestion and improve food intake; pepper, ginger, inula flower, cortex albiziae, lentinula edodes and black sesame are used as auxiliary drugs to warm middle, stop pain, calm nerves, relieve depression, activate blood and eliminate carbuncle; prepared rehmannia root, radix glycyrrhizae, carrot, mulberry, spina date seed and codonopsis pilosula are used as adjuvant drugs to improve immunity, nourish blood, nourish yin, reinforce essence, benefit marrow, strengthen middle and tonify qi.

Description

Rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy

Technical field

The present invention relates to the field of Chinese medicines, specifically rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy.

Background technology

Chemicotherapy is a kind of common mode for the treatment of tumor patient, normally kill cancerous cell with high-energy radiation or to the method for injected chemical material in patient body, but chemicotherapy also can damage human normal cell while killing cancerous cell, there is sizable side effect, be embodied in: the situation such as whole body fatigue and weak, lethargy, cold perspiration, drowsiness, alopecia can appear in patient; The immune system of patient can be damaged after chemotherapy, cause immunodeficiency or decline; Most of chemotherapeutics all can cause bone marrow depression, shows as leukocyte and platelet decline, even causes erythrocyte, hematochrome to decline; A lot of chemotherapeutics meeting stimulating gastrointestinal mucous membrane, thus cause appetite decline, dietary amount minimizing, Nausea and vomiting, abdominal distention, stomachache, diarrhoea or constipation, radiotherapy kills cancerous cell with high-energy radiation, inevitably human normal cell is damaged during radiotherapy, cause patient's resistance to decline, have a strong impact on the rehabilitation process of patient.

Do not have active drug to chemicotherapy side effect at present, although some drugs can play certain mitigation, it, while reduction side effect, also inhibits the killing action of chemicotherapy to tumor cell.

Summary of the invention

The object of the invention is to the untoward reaction that the Western medicine after overcoming the deficiencies in the prior art part and tumor patient chemicotherapy brings, formulated by clinic tests and repeated verification, meet Traditional Chinese Medicine theory, thus rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy is provided, wherein worsen for the anticancer Tumor suppression of monarch drug spreads with Herba Hedyotidis Diffusae, Radix Actinidiae Chinensis, Semen Ciceris Arietini, Aspongopus, Rhizoma Sparganii; Be ministerial drug YIN nourishing and the production of body fluid promoting with Radix Liriopes, Rhizoma Kaempferiae, Folium Crataegi, Rhizoma Polygonati Odorati, Fructus Setariae Germinatus, Fructus Hippophae, circulation of qi promoting warming middle-JIAO, promote peptic digestion, improve dietary amount; With Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Flos Inulae, Cortex Albiziae, Lentinus Edodes, Semen Sesami Nigrum for accessory drugs warming middle-JIAO to relieve pain, resolving depression of calming the nerves, eliminating carbuncle of invigorating blood circulation; With Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Dauci Sativae, Fructus Mori, Semen Ziziphi Spinosae, Radix Codonopsis for adjuvant drug raising immunity nourishing the blood and yin, vital essence replenishing and marrow benifiting, invigorating the spleen and replenishing QI.

Rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy of the present invention is that the raw material of joining part by following weight is made:

Herba Hedyotidis Diffusae 20-30 part, Radix Actinidiae Chinensis 20-30 part, Semen Ciceris Arietini 20-30 part, Aspongopus 20-30 part, Rhizoma Sparganii 20-30 part, Radix Liriopes 15-25 part, Rhizoma Kaempferiae 15-25 part, Folium Crataegi 15-25 part, Rhizoma Polygonati Odorati 15-25 part, Fructus Setariae Germinatus 15-25 part, Fructus Hippophae 15-25 part, Pericarpium Zanthoxyli 10-20 part, Rhizoma Zingiberis Recens 10-20 part, Flos Inulae 10-20 part, Cortex Albiziae 10-20 part, Lentinus Edodes 10-20 part, Semen Sesami Nigrum 10-20 part, Radix Rehmanniae Preparata 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Dauci Sativae 5-10 part, Fructus Mori 5-10 part, Semen Ziziphi Spinosae 5-10 part, Radix Codonopsis 5-10 part,

Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is capsule, be specially:

Take Herba Hedyotidis Diffusae in proportion, Radix Actinidiae Chinensis, Semen Ciceris Arietini, Aspongopus, Rhizoma Sparganii, Radix Liriopes, Rhizoma Kaempferiae, Folium Crataegi, Rhizoma Polygonati Odorati, Fructus Setariae Germinatus, Fructus Hippophae, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Flos Inulae, Cortex Albiziae, Lentinus Edodes, Semen Sesami Nigrum, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Dauci Sativae, Fructus Mori, Semen Ziziphi Spinosae, the each herbal medicine of Radix Codonopsis, remove impurity respectively, clean, dry parching to brown, by medicament mixed, the clear water adding four times amount medicines soaks 1 hour, in immigration marmite, big fire is to boiling, then slow fire boiling 3 hours, leach medicinal liquid, the clear water adding qdx medicine again continues decoction 2 hours, get supernatant and send that vaporizer is concentrated makes extractum, extractum is sent in drying baker and is dried at 130 DEG C of temperature, be ground into 300-400 smalls, incapsulate by 0.5g/ grain after sterilization, be finished product.

Instructions of taking: seven days courses for the treatment of, every day 2 times, each 2, warm water clothes send, and take period, avoid that raw meat is peppery, tobacco and wine.

Rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy of the present invention is that the raw material of joining part by following weight is made:

Herba Hedyotidis Diffusae 22-28 part, Radix Actinidiae Chinensis 22-28 part, Semen Ciceris Arietini 22-28 part, Aspongopus 22-28 part, Rhizoma Sparganii 22-28 part, Radix Liriopes 16-24 part, Rhizoma Kaempferiae 16-24 part, Folium Crataegi 16-24 part, Rhizoma Polygonati Odorati 16-24 part, Fructus Setariae Germinatus 16-24 part, Fructus Hippophae 16-24 part, Pericarpium Zanthoxyli 12-18 part, Rhizoma Zingiberis Recens 12-18 part, Flos Inulae 12-18 part, Cortex Albiziae 12-18 part, Lentinus Edodes 12-18 part, Semen Sesami Nigrum 12-18 part, Radix Rehmanniae Preparata 6-8 part, Radix Glycyrrhizae 6-8 part, Radix Dauci Sativae 6-8 part, Fructus Mori 6-8 part, Semen Ziziphi Spinosae 6-8 part, Radix Codonopsis 6-8 part,

Present invention also offers the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is soup potus, be specially:

Each component is pulverized respectively, be mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, decoct 2 ~ 4 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boils rear slow fire, and second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup potus.

Rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy of the present invention is that the raw material of joining part by following weight is made:

Herba Hedyotidis Diffusae 25 parts, Radix Actinidiae Chinensis 25 parts, Semen Ciceris Arietini 25 parts, Aspongopus 25 parts, Rhizoma Sparganii 25 parts, Radix Liriopes 20 parts, Rhizoma Kaempferiae 20 parts, Folium Crataegi 20 parts, Rhizoma Polygonati Odorati 20 parts, Fructus Setariae Germinatus 20 parts, Fructus Hippophae 20 parts, 15 parts, Pericarpium Zanthoxyli, 15 parts, Rhizoma Zingiberis Recens, Flos Inulae 15 parts, Cortex Albiziae 15 parts, 15 parts, Lentinus Edodes, Semen Sesami Nigrum 15 parts, Radix Rehmanniae Preparata 7 parts, 7 parts, Radix Glycyrrhizae, 7 parts, Radix Dauci Sativae, 7 parts, Fructus Mori, Semen Ziziphi Spinosae 7 parts, Radix Codonopsis 7 parts.

the property of medicine and the pharmacology of Chinese herbal medicine selected by the present invention are respectively:

Herba Hedyotidis Diffusae:

[meridian distribution of property and flavor] bitter but sweet flavor, warm in nature, nontoxic.Enter the heart, liver, spleen three warp.

[function cures mainly] hyoscine, has the function of heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.Cure mainly the diseases such as malignant tumor, appendicitis, hepatitis, bronchitis, tonsillitis, laryngitis, urinary system infection, pelvic inflammatory disease, adnexitis; Furuncle carbuncle, venom are controlled in external.Modern Chinese medicine is clinical is used for the treatment of the kinds cancers such as gastric cancer, the esophageal carcinoma, intestinal cancer, uterus carcinoma, nasopharyngeal carcinoma.

Radix Actinidiae Chinensis:

[nature and flavor] " Shaanxi Chinese herbal medicine ": " acid is micro-sweet, cool, slightly poisonous."

[function cures mainly] heat clearing away, diuresis, invigorates blood circulation, detumescence.Treating the liver is scorching, edema, traumatic injury, rheumatic arthritis, stranguria with turbid discharge, leukorrhagia, furuncle, scrofula.1. " Guizhou side's medicine among the people collection ": " diuresis, cathartic.Control ascites; External synthetism, disappear wound." 2. " Zhejiang conventional medical herbs among the people ": " stomach invigorating, invigorates blood circulation, lactogenic, antiinflammatory." 3. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence, anticancer.Control furuncle, scrofula."

Semen Ciceris Arietini:

Regulating middle-JIAO and making the adverse QI downward, diuresis, separates sore.Control cramp caused by acute vomiting and diarrhea, beriberi, carbuncle.

1. " Shaoxing edits Zhenglei Bencao ": a homophony battalion defends, flat gas in benefit.

2. " daily book on Chinese herbal medicine ": lower milk of cooking.

3. " detailed outline ": grind into powder and be coated with carbuncle, variola.

4. " Bencao Congxin ": reason taste.

5. " medical center bun is wanted ": diuresis.

6. " with breath occupy diet spectrum ": cook, and in promote the production of body fluid, the therapeutic method to keep the adverse QI flowing downwards of quenching the thirst, lactogenesis relieving distension.

Trophic analysis: be rich in vitamin C and can the enzyme of nitrosamine in decomposer in the tender leaf of Huis soybean pod and bean seedlings, can decomposing nitrosamine, has the effect of anti-cancer and cancer-preventing.Semen Ciceris Arietini and general vegetable different, the materials such as the acid of contained only wooden fork, gibberellins and the solidifying element of plant, have anti-inflammation, strengthen metabolic function.Containing the dietary fiber compared with horn of plenty in garden pea and bean seedlings, can constipation be prevented, have bowel relieving effect.1. enhancing human body immunity function: the various nutrient substance being rich in needed by human body in Semen Ciceris Arietini, especially containing high quality protein, can improve resistance against diseases and the rehabilitation ability of body.2. cancer preventing and treating: be rich in carotene in Semen Ciceris Arietini, can prevent the synthesis of human carcinogen's material after edible, thus reduces the formation of cancerous cell, reduces the sickness rate of human carcinoma.3. tonneau large intestine: be rich in crude fibre in Semen Ciceris Arietini, can promote intestinal peristalsis, keeps stool freely, can play the effect of clean large intestine.

Aspongopus:

[meridian distribution of property and flavor] property is salty, pungent, warm; Return stomach, liver, large intestine channel.

[effect] regulating QI to relieve pain, warming middle-JIAO is supporing yang, relieves internal heat anticancer, for cold syndrome of the stomach distending pain, and stomachache due to hyperactive liver-QI attacking the stomach, impotence due to deficiency of the kidney, soreness of waist and knee joint.

Rhizoma Sparganii:

[another name] a kind of reed mentioned in ancient books root (" the Master of Preserving Simplicity "), RHZOMA SPARGANII (" Kaibao Bencao "), red Rhizoma typhae (" Bencao Tujing "), RHIZOMA SPARGANII (" medical material compilation of data "), rhizoma scirpi (herbal for Relief of Famines), a kind of reed mentioned in ancient books grass (" word woods "), Herba Caricis Phacotae (supplement to Thousand Golden Prescriptions)

[nature and flavor] bitter in the mouth, property is put down.

[effect] removing blood stasis, circulation of qi promoting, removing food stagnancy pain relieving.

[clinical practice] is applicable to kinds of tumors, as ovarian cancer, cervical cancer, hepatocarcinoma etc.Normal with Rhizoma Cyperi, Rhizoma Curcumae, Radix Arnebiae (Radix Lithospermi), Fructus Fici Pumilae etc. compatibility treat QI and blood tie amass, ovarian cancer, cervical cancer etc. that the blood stasis stasis of blood is stagnant.The hepatocarcinoma that compatibility treatment qi depression to blood stasis, the pyretic toxicity such as conventional Herba Hedyotidis Diffusae, Pericarpium Arecae, Poria, Rhizoma Curcumae pent up.In addition these product are also applicable to stagnation of QI and blood, abdominal part caking, hepatosplenomegaly, amenorrhea stomachache, food stagnation distending pain etc.

Radix Liriopes

[another name] large Radix Ophiopogonis, native Radix Ophiopogonis, Chloranthus elatior, Radix Ophiopogonis;

[meridian distribution of property and flavor] sweet, micro-hardship, is slightly cold; GUIXIN, lung, stomach warp.

[function cures mainly] YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.

Rhizoma Kaempferiae:

Have another name called, Rhizoma Kaempferiae (" sea side "), three rely (" product converge with essence want "), Rhizoma Kaempferiae, mountain peppery (" detailed outline ") ， tri-Lai (" South Uietnam notes "), husky Rhizoma Zingiberis Recens (" south of the Five Ridges gather medicinal herbs record ");

[meridian distribution of property and flavor] temperature; Pungent; Return stomach warp

[function cures mainly] circulation of qi promoting warming middle-JIAO, helps digestion, pain relieving.For chest and diaphragm distension, coldness and pain in the epigastrium, diet does not disappear.

Folium Crataegi:

[nature and flavor] acid; Flat;

[function cures mainly] has the function of promoting digestion and invigorating the stomach, activating blood circulation to dissipate blood stasis, convergence dysentery relieving.To meat amass phlegm retention, feeling of fullness acid regurgitation, dysentery hemorrhoidal hamorrhage, lumbago hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate etc., all effective in cure.Main dermatitis rhus, ulcer being unable to heal, hypertension.

Rhizoma Polygonati Odorati:

[meridian distribution of property and flavor] is sweet, is slightly cold, and attaches to the lung and stomach meridians.

[function cures mainly] nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, for lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Pericarpium Zanthoxyli:

[meridian distribution of property and flavor] acrid in the mouth, warm in nature.Slightly poisonous.Return spleen, stomach, kidney channel.

[effect] has the function of warming middle-JIAO to relieve pain, killing parasites for relieving itching.Pericarpium Zanthoxyli is slightly poisonous, and pungent using warming therapy is very strong, and the effect of external killing parasites for relieving itching is good.For scabies, eczema or skin pruritus.Take pepper water and can remove parasite; There is effect of fragrant stomach invigorating, warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing removing toxic substances, antipruritic solution raw meat.

[pharmacology] bacteriostatic test: Pericarpium Zanthoxyli is to anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, lemon yellow and 10 kinds of gram positive bacterias such as Staphylococcus albus, bacillus subtilis, and the enteral pathogenic bacterium such as escherichia coli, Song Nei Shi dysentery bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have obvious inhibitory action.The water logging agent of 1:4 also has inhibitory action to star nocardia.According to animal experiment, a small amount of clothes that continue can promote relevant metabolic glandular development, and volume then can promote the glandular development about reproduction.This just demonstrates the understanding of ancients' " temperature male wind-supplying kidney ".

Rhizoma Zingiberis Recens:

[nature and flavor] pungent, tepor, return lung taste warp

[effect] relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, solving toxin of fish and crab, separates poison of drug; Deliver, cold expelling, preventing or arresting vomiting, open expectorant, carbuncle skin ulcer.

Fructus Mori:

[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.

[function cures mainly] controls hepatic and renal YIN deficiency, sends and takes off, constipation, and order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, has potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and has auxiliary curative effect to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science is thought, Fructus Mori is sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.

Fructus Setariae Germinatus:

[meridian distribution of property and flavor] is sweet, flat.Return spleen, stomach warp.

[effect] promoting digestion and removing stagnation; Spleen benefiting and stimulating the appetite.Stagnate for food stagnation; Distension is had loose bowels; Insufficiency of the spleen few food; Beriberi edema.Help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for not hungry lack of appetite.It is stagnant that Fructus Setariae Germinatus (parched to brown) is apt to eliminate indigestion, do not disappear for stagnant.

Fructus Hippophae:

[another name] Da Er, Fructus Elaeagni Angustifoliae, fructus hippophae, large Er Buxing, vinegar willow, acid thorn, sour Liu Liu, it examines a day Cannes, acid thorn, black thorn, yellow acid thorn, acid are stung.

[nature and flavor] sour in the mouth; Puckery; Warm in nature

[effect] relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; Promoting blood circulation to remove blood stasis.Main cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal is scorching; Amenorrhea; Traumatic injury congestive edema.

The nutritive value of Fructus Hippophae is very high, containing fat, protein, saccharide, salt and vitamin, and rich content.

Flos Inulae:

[effect classification] antitussive; Expectorant; Softening the hard mass medicine; Diuretic medicine.

[meridian distribution of property and flavor] bitter in the mouth; Pungent; Salty; Tepor.Return lung; Stomach; Large intestine channel.

[effect] sending down the abnormal ascending QI, expectorant, row water, preventing or arresting vomiting.For cough due to wind and cold, phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, epigastric oppression and rigidity.

Cortex Albiziae:

[ meridian distribution of property and flavor]sweet; Flat.1. " herbal classic ": sweet, flat.2. " book on Chinese herbal medicine converges and says ": sweet, Wen Ping.Enter the heart, Liver Channel.1. " Thunder God concocts property of medicine solution ": enter heart channel.2. " book on Chinese herbal medicine is new again ": enter the heart, liver two warp.

[efficacy effect]to calm the nerves resolving depression, eliminating carbuncle of invigorating blood circulation.Main irritability; Melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury.1. " herbal classic ": main settling five organs, and will, make us happy carefree.2. supplement to the Herbal: parasite killing.3. " Japan hanako materia medica ": soft extracts, subduing inflammation reuniting the fractured tendons and bones.4. " detailed outline ": and blood, detumescence, pain relieving.5. " classify herbal ": disappear scrofula.6. " animals and plants Folk medicine ": control cough.7. Nanchuan " conventional Chinese herbal medicine handbook ": control that the motive is restless, insomnia and clonic spasm of the muscle.

Lentinus Edodes:

Lentinus Edodes is rich in vitamin B group, ferrum, potassium, provitamin D (changing into vitamin D after Exposure to Sunlight), sweet in the mouth, and property is put down.Cure mainly loss of appetite, weak breath is weak.

Radix Rehmanniae Preparata:

[meridian distribution of property and flavor] property is sweet, tepor, enters liver, kidney channel.

[effect] nourishing the blood and yin, vital essence replenishing and marrow benifiting.

Radix Glycyrrhizae:

[nature and flavor] sweet in the mouth is put down,

[effect] invigorating the spleen and replenishing QI, lung moistening are eliminated the phlegm, heat-clearing and toxic substances removing.

Semen Sesami Nigrum:

[nature and flavor] are flat, sweet in the mouth.

[effect] invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry; For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.

Semen Ziziphi Spinosae:

[nature and flavor] property is put down, sweet in the mouth, acid; GUIXIN, Liver Channel.

[function cures mainly] nourishes heart, and calms the nerves, arresting sweating.For neurasthenia, insomnia, dreaminess, night sweat.

Radix Codonopsis:

[meridian distribution of property and flavor] sweet in the mouth, micro-acid, flat.Return spleen, lung meridian.

[function cures mainly] invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

detailed description of the invention:

embodiment 1, formula:

Herba Hedyotidis Diffusae 20mg, Radix Actinidiae Chinensis 20mg, Semen Ciceris Arietini 20mg, Aspongopus 20mg, Rhizoma Sparganii 20mg, Radix Liriopes 15mg, Rhizoma Kaempferiae 15mg, Folium Crataegi 15mg, Rhizoma Polygonati Odorati 15mg, Fructus Setariae Germinatus 15mg, Fructus Hippophae 15mg, Pericarpium Zanthoxyli 10mg, Rhizoma Zingiberis Recens 10mg, Flos Inulae 10mg, Cortex Albiziae 10mg, Lentinus Edodes 10mg, Semen Sesami Nigrum 10mg, Radix Rehmanniae Preparata 5mg, Radix Glycyrrhizae 5mg, Radix Dauci Sativae 5mg, Fructus Mori 5mg, Semen Ziziphi Spinosae 5mg, Radix Codonopsis 5mg;

Preparation method: take Herba Hedyotidis Diffusae in proportion, Radix Actinidiae Chinensis, Semen Ciceris Arietini, Aspongopus, Rhizoma Sparganii, Radix Liriopes, Rhizoma Kaempferiae, Folium Crataegi, Rhizoma Polygonati Odorati, Fructus Setariae Germinatus, Fructus Hippophae, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Flos Inulae, Cortex Albiziae, Lentinus Edodes, Semen Sesami Nigrum, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Dauci Sativae, Fructus Mori, Semen Ziziphi Spinosae, the each herbal medicine of Radix Codonopsis, remove impurity respectively, clean, dry parching to brown, by medicament mixed, the clear water adding four times amount medicines soaks 1 hour, in immigration marmite, big fire is to boiling, then slow fire boiling 3 hours, leach medicinal liquid, the clear water adding qdx medicine again continues decoction 2 hours, get supernatant and send that vaporizer is concentrated makes extractum, extractum is sent in drying baker and is dried at 130 DEG C of temperature, be ground into 300-400 smalls, incapsulate by 0.5g/ grain after sterilization, be finished product,

Instructions of taking: seven days courses for the treatment of, every day 2 times, each 2, warm water clothes send, and take period, avoid that raw meat is peppery, tobacco and wine.

embodiment 2, formula:

Herba Hedyotidis Diffusae 22mg, Radix Actinidiae Chinensis 22mg, Semen Ciceris Arietini 22mg, Aspongopus 22mg, Rhizoma Sparganii 22mg, Radix Liriopes 16mg, Rhizoma Kaempferiae 16mg, Folium Crataegi 16mg, Rhizoma Polygonati Odorati 16mg, Fructus Setariae Germinatus 16mg, Fructus Hippophae 16mg, Pericarpium Zanthoxyli 12mg, Rhizoma Zingiberis Recens 12mg, Flos Inulae 12mg, Cortex Albiziae 12mg, Lentinus Edodes 12mg, Semen Sesami Nigrum 12mg, Radix Rehmanniae Preparata 6mg, Radix Glycyrrhizae 6mg, Radix Dauci Sativae 6mg, Fructus Mori 6mg, Semen Ziziphi Spinosae 6mg, Radix Codonopsis 6mg;

Preparation method:

Each component is pulverized respectively, be mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, decoct 2 ~ 4 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boils rear slow fire, and second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup potus.

Instructions of taking: seven days courses for the treatment of, every day 2 times, each 10ml, takes period, avoids that raw meat is peppery, tobacco and wine.

embodiment 3, formula:

Herba Hedyotidis Diffusae 25mg, Radix Actinidiae Chinensis 25mg, Semen Ciceris Arietini 25mg, Aspongopus 25mg, Rhizoma Sparganii 25mg, Radix Liriopes 20mg, Rhizoma Kaempferiae 20mg, Folium Crataegi 20mg, Rhizoma Polygonati Odorati 20mg, Fructus Setariae Germinatus 20mg, Fructus Hippophae 20mg, Pericarpium Zanthoxyli 15mg, Rhizoma Zingiberis Recens 15mg, Flos Inulae 15mg, Cortex Albiziae 15mg, Lentinus Edodes 15mg, Semen Sesami Nigrum 15mg, Radix Rehmanniae Preparata 7mg, Radix Glycyrrhizae 7mg, Radix Dauci Sativae 7mg, Fructus Mori 7mg, Semen Ziziphi Spinosae 7mg, Radix Codonopsis 7mg.

Preparation method is identical with embodiment 1 with instructions of taking.

embodiment 4, formula:

Herba Hedyotidis Diffusae 28mg, Radix Actinidiae Chinensis 28mg, Semen Ciceris Arietini 28mg, Aspongopus 28mg, Rhizoma Sparganii 28mg, Radix Liriopes 24mg, Rhizoma Kaempferiae 24mg, Folium Crataegi 24mg, Rhizoma Polygonati Odorati 24mg, Fructus Setariae Germinatus 24mg, Fructus Hippophae 24mg, Pericarpium Zanthoxyli 18mg, Rhizoma Zingiberis Recens 18mg, Flos Inulae 18mg, Cortex Albiziae 18mg, Lentinus Edodes 18mg, Semen Sesami Nigrum 18mg, Radix Rehmanniae Preparata 8mg, Radix Glycyrrhizae 8mg, Radix Dauci Sativae 8mg, Fructus Mori 8mg, Semen Ziziphi Spinosae 8mg, Radix Codonopsis 8mg;

Preparation method is identical with embodiment 1 with instructions of taking.

embodiment 5, formula:

Herba Hedyotidis Diffusae 30mg, Radix Actinidiae Chinensis 30mg, Semen Ciceris Arietini 30mg, Aspongopus 30mg, Rhizoma Sparganii 30mg, Radix Liriopes 25mg, Rhizoma Kaempferiae 25mg, Folium Crataegi 25mg, Rhizoma Polygonati Odorati 25mg, Fructus Setariae Germinatus 25mg, Fructus Hippophae 25mg, Pericarpium Zanthoxyli 20mg, Rhizoma Zingiberis Recens 20mg, Flos Inulae 20mg, Cortex Albiziae 20mg, Lentinus Edodes 20mg, Semen Sesami Nigrum 20mg, Radix Rehmanniae Preparata 10mg, Radix Glycyrrhizae 10mg, Radix Dauci Sativae 10mg, Fructus Mori 10mg, Semen Ziziphi Spinosae 10mg, Radix Codonopsis 10mg;

Preparation method is identical with embodiment 1 with instructions of taking.

toxicological experiment

Choose KM mice 60, be divided into treatment group and matched group at random according to body weight, often organize 30, male and female half and half, before administration, fasting can't help water 12 hours, and treatment group mice of the present invention is according to the administration capacity intravenously administrable of 0.25ml/10g; Matched group gavage water.At once the reaction of animal is observed after administration, comprise the form of animal, behavioral activity, the mental status, appetite, defecation and color thereof, fur, nose, eye, mouth with or without abnormal secretion thing and animal dead situation, the dead timely postmortem of animal, if there is macroscopic pathological changes, carries out histopathologic examination.Administration is observed once for the 1st day every 1 hour, and later every day observes once, Continuous Observation 7 days, the reaction of record animal toxicity and death condition.Weigh mice before the test, the body weight of the 3rd day and the 7th day after test.From the response situation overall merit result of the test of body weight and animal, obtain the maximum tolerated dose of injection of the present invention to mice single dose intravenous and gastric infusion.If occur dead, then carry out acute median lethal dose(LD 50) (LD ₅₀) mensuration, through experiment, KM mice single dose intravenous gives tested injection 17.075g crude drug/kg of the present invention, be equivalent to 187.5 times of the clinical maximum consumption per day of people, the righting reflex loss of animal at once after administration, palpitating speed, in 3min, righting reflex recovers, heartbeating recovery is normal, animal performance without exception, there is not any exception in whole duration of test, body weight increases with the prolongation of test period, with concurrent control group zero difference (p > 0.05), duration of test has no animal dead.Put to death mice at the end of observation period, postmortem is without macroscopic change, and therefore, the quantity of this medicine of this test prompting is a quite safe dosage.

Claims (5)

1. a rehabilitation Chinese medicine composition after adjuvant therapy patient chemicotherapy, is characterized in that: be that the raw material of joining part by following weight is made:

Herba Hedyotidis Diffusae 20-30 part, Radix Actinidiae Chinensis 20-30 part, Semen Ciceris Arietini 20-30 part, Aspongopus 20-30 part, Rhizoma Sparganii 20-30 part, Radix Liriopes 15-25 part, Rhizoma Kaempferiae 15-25 part, Folium Crataegi 15-25 part, Rhizoma Polygonati Odorati 15-25 part, Fructus Setariae Germinatus 15-25 part, Fructus Hippophae 15-25 part, Pericarpium Zanthoxyli 10-20 part, Rhizoma Zingiberis Recens 10-20 part, Flos Inulae 10-20 part, Cortex Albiziae 10-20 part, Lentinus Edodes 10-20 part, Semen Sesami Nigrum 10-20 part, Radix Rehmanniae Preparata 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Dauci Sativae 5-10 part, Fructus Mori 5-10 part, Semen Ziziphi Spinosae 5-10 part, Radix Codonopsis 5-10 part.

2. rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy according to claim 1, is characterized in that: be that the raw material of joining part by following weight is made:

Herba Hedyotidis Diffusae 22-28 part, Radix Actinidiae Chinensis 22-28 part, Semen Ciceris Arietini 22-28 part, Aspongopus 22-28 part, Rhizoma Sparganii 22-28 part, Radix Liriopes 16-24 part, Rhizoma Kaempferiae 16-24 part, Folium Crataegi 16-24 part, Rhizoma Polygonati Odorati 16-24 part, Fructus Setariae Germinatus 16-24 part, Fructus Hippophae 16-24 part, Pericarpium Zanthoxyli 12-18 part, Rhizoma Zingiberis Recens 12-18 part, Flos Inulae 12-18 part, Cortex Albiziae 12-18 part, Lentinus Edodes 12-18 part, Semen Sesami Nigrum 12-18 part, Radix Rehmanniae Preparata 6-8 part, Radix Glycyrrhizae 6-8 part, Radix Dauci Sativae 6-8 part, Fructus Mori 6-8 part, Semen Ziziphi Spinosae 6-8 part, Radix Codonopsis 6-8 part.

3. rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy according to claim 1, is characterized in that: be that the raw material of joining part by following weight is made:

Herba Hedyotidis Diffusae 25 parts, Radix Actinidiae Chinensis 25 parts, Semen Ciceris Arietini 25 parts, Aspongopus 25 parts, Rhizoma Sparganii 25 parts, Radix Liriopes 20 parts, Rhizoma Kaempferiae 20 parts, Folium Crataegi 20 parts, Rhizoma Polygonati Odorati 20 parts, Fructus Setariae Germinatus 20 parts, Fructus Hippophae 20 parts, 15 parts, Pericarpium Zanthoxyli, 15 parts, Rhizoma Zingiberis Recens, Flos Inulae 15 parts, Cortex Albiziae 15 parts, 15 parts, Lentinus Edodes, Semen Sesami Nigrum 15 parts, Radix Rehmanniae Preparata 7 parts, 7 parts, Radix Glycyrrhizae, 7 parts, Radix Dauci Sativae, 7 parts, Fructus Mori, Semen Ziziphi Spinosae 7 parts, Radix Codonopsis 7 parts.

4. rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy according to claim 1-3 any one, is characterized in that: the preparation method additionally providing above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is soup potus, is specially:

Each component is pulverized respectively, be mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, decoct 2 ~ 4 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boils rear slow fire, and second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup potus.

5. rehabilitation Chinese medicine composition after a kind of adjuvant therapy patient chemicotherapy according to claim 1-3 any one, is characterized in that: the preparation method additionally providing above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is capsule, is specially:

Take Herba Hedyotidis Diffusae in proportion, Radix Actinidiae Chinensis, Semen Ciceris Arietini, Aspongopus, Rhizoma Sparganii, Radix Liriopes, Rhizoma Kaempferiae, Folium Crataegi, Rhizoma Polygonati Odorati, Fructus Setariae Germinatus, Fructus Hippophae, Pericarpium Zanthoxyli, Rhizoma Zingiberis Recens, Flos Inulae, Cortex Albiziae, Lentinus Edodes, Semen Sesami Nigrum, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Dauci Sativae, Fructus Mori, Semen Ziziphi Spinosae, the each herbal medicine of Radix Codonopsis, remove impurity respectively, clean, dry parching to brown, by medicament mixed, the clear water adding four times amount medicines soaks 1 hour, in immigration marmite, big fire is to boiling, then slow fire boiling 3 hours, leach medicinal liquid, the clear water adding qdx medicine again continues decoction 2 hours, get supernatant and send that vaporizer is concentrated makes extractum, extractum is sent in drying baker and is dried at 130 DEG C of temperature, be ground into 300-400 smalls, incapsulate by 0.5g/ grain after sterilization, be finished product.