CN103830713B - Be used for the treatment of medicine of chicken wind-cold type cough and preparation method thereof - Google Patents

Be used for the treatment of medicine of chicken wind-cold type cough and preparation method thereof Download PDF

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CN103830713B
CN103830713B CN201410103548.9A CN201410103548A CN103830713B CN 103830713 B CN103830713 B CN 103830713B CN 201410103548 A CN201410103548 A CN 201410103548A CN 103830713 B CN103830713 B CN 103830713B
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medicine
rhizoma
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semen
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CN103830713A (en
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李佃场
胡莉萍
朱瑞良
黄河
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Guangzhou Hope Feed Co., Ltd.
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Shandong New Hope Liuhe Group Co Ltd
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention discloses medicine being used for the treatment of chicken wind-cold type cough and preparation method thereof, medicine comprises following raw medicinal material: the Rhizoma Pinelliae, Poria, Rhizoma Zingiberis Recens, Fructus Gleditsia, Fructus Perillae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Sinapis Albae, Radix Platycodonis, Extract Carnis Bovis, Semen Benincasae, Folium Perillae, Cacumen Tamaricis, Semen Armeniacae Amarum, Flos Inulae, Rhizoma Cynanchi Stauntonii, adenostemma laveniaKuntze, gray gum, Herba Centipedae, platform mushroom, Exocarpium Citrulli, Herba Schizonepetae, Ou Zeqin, Radix Saposhnikoviae and Radix Glycyrrhizae.The invention has the beneficial effects as follows: medicine of the present invention has expectorant cough suppressant and anti-asthmatic, the curative effect of the cold expelling that induces sweat, have evident in efficacy at treatment chicken wind-cold type cough, side effect is low, the advantages such as cure rate is high, short treating period, not easily recurrence.

Description

Be used for the treatment of medicine of chicken wind-cold type cough and preparation method thereof
Technical field
The present invention relates to herbal medicine technical field, be particularly a kind ofly used for the treatment of medicine of chicken wind-cold type cough and preparation method thereof.
Background technology
Chicken is normally breathing per minute 20 ~ 40 times, and it is exactly breathe heavily that frequency of respiration is accelerated.Have with mouth breathing and stridulate.Chicken breathes heavily the most easily to be recognized when chicken group is quiet in night.High temperature, stifling etc. stress make chicken accelerated breathing, and one or more diseases can make chicken breathe heavily and have other respiratory symptoms, and what have is called " respiratory complication (levying) " or directly claims " respiratory symptom of chicken ", " respiratory tract disease ".
The existing antibacterial of chicken cough cause of disease, also has virus, some appearance mixed infection.Traditional Chinese veterinary medicine thinks the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, the criminal's of accumulateing lung in pathogenic factor, and sputum blocks trachea, causes cough and asthma, then evilly passes edema caused by disorder of QI, checks lung machine, so that clear respectful mistake department, and the heap soil or fertilizer over and around the roots of QI rising in reverse order expectorant, it is unfavorable to breathe.Disease sees heating, body temperature raises 1-2 DEG C, thirsty, and dehisce to pant, stretch neck and face upward head, breathe and have rale sound, night, more some trouble pertussis went out with blood streak sputum, the congested swelling of pharyngolaryngeal mucosa, coating pseudomembrane, hat whisker purple.Serious trouble chicken coma is slow-witted vertical, and paralysis of even twitching, until dead.
Chinese veterinarian thinks, breathes heavily disease and refers to due to diseases caused by exogenous pathogenic factor or internal injury, cause impairment of dispersing and descending function of the lung, abnormal rising of lung-QI or gas without lead, kidney loses to take the photograph and receives, so that dyspnea etc. is a kind of disease of main clinical characteristics.Breathe heavily disease ancient literature and also claim " breath ", " dyspnea with elevated shoulders ", " upper gas ", " inverse gas ", " dyspnea with rapid and short breath " etc."Nei Jing" has more discussion to breathing heavily disease.As " Ling Shu Miraculous Pivot or Divine Axis five is read five and made " is said: " therefore lung patient, dyspnea and flaring of nares." " Plain Questions lift pain opinion " add: " labor is then panted sweating." point out to breathe heavily the existing diseases caused by exogenous pathogenic factor of the disease cause of disease, also have internal injury, pathogenesis also has deficiency and excess not.In addition, " Plain Questions numbness opinion " cloud: " obstruction of heart-QI person, arteries and veins is obstructed, tired then severe palpitation, sudden and violent upper gas and breathing heavily." " Plain Questions passages through which vital energy circulates another matter " cloud; " pendant probably, is breathed heavily for liver to some extent." though prompting breathes heavily based on lung, also relates to that it is dirty.The cause of disease of breathing heavily disease is very complicated, exopathogen invasion and attack, improper diet, etc. all can become the cause of disease of breathing heavily disease, cause impairment of dispersing and descending function of the lung, abnormal rising of lung-QI or gas without lead, kidney loses to take the photograph to receive just to become breathes heavily disease.The heresy of exopathogen invasion and attack affection of exogenous wind-cold or wind heat, fail to show in time to fall apart, heresy is accumulate in lung, and stop up resistance lung qi, lung qi must not be declared and be fallen, and thus superinverse is breathed heavily.If kidney yang is weak, the not main water of kidney, pathogenic water is violated, and dry lung insults the heart, abnormal rising of lung-QI, and flaccidity of the heart-yang, also can cause and breathe heavily, and this belongs to the time of deficiency complicated with excess.Breathe heavily the sick position of disease, main dirty at lung and kidney, relevant with liver, spleen, the heart.Because of the lung being the dominator of QI, department breathes, outer conjunction fur, and interior be the canopy of the five internal organs, if exopathogen attacks lung, or its disease of ZANG-organs gas is violated, all can make obstruction of lung-QI, impairment of dispersing and descending function of the lung, breathe unfavorable and cause dyspnea with rapid and short breath, or making decline of lung-QI, and gas is become homeless and led and dyspnea with rapid and short breath.The kidney being the root of QI, with lung with take charge of the cashier of gas, therefore nephrons is not consolidated, and takes the photograph to receive not normal, and gas does not return unit, and negative and positive do not continue mutually, also can QI rising in reverse order in facies pulmonalis cordis for breathing heavily.If the turbid pathogenic fluid-retention of insufficiency of the spleen expectorant is disturbed, or adverse flow of liver-QI is taken advantage of also can cause and is breathed heavily, then for the disease of liver spleen affects in lung.Obstruction of heart-QI with dyspnea, then when betiding collapse syndrome caused by dyspnea.
The pathologic feature breathing heavily disease has deficiency and excess two class.Excess-dyspnea at lung, for exopathogen, expectorant are turbid, stagnation of liver-QI QI rising in reverse order, lung stop up pathogen and declare fall unfavorable; Dyspnea due to deficiency when the lung of duty, kidney two dirty, because vital essence is not enough, gas the moon loss and cause the not main gas of lung, failure of the kidney in receiving QI.Therefore the basic pathogenesis breathing heavily disease to be the lifting cashier of mechanism of qi not normal, " be real at lung, be void at kidney ".The mixed person of the state of an illness, often can deficiency in the lower and excess in the upper, and simulataneous insufficiency and excessive is also shown in.But in the different phase of PD, give priority between deficiency and excess, or transform mutually.If pneumonopathy and spleen, child-organ disease involving its motherorgan, then temper is also empty, insufficiency of the spleen mistake fortune, accumulatively wet raise phlegm, and upper stain is in lung, and obstruction of lung-QI, cloth is lost in gas Tianjin, and blood is unfavorable, and can form the turbid blood stasis of expectorant, now pathogenesis is based on the domination of pathogen, or the weakened body resistance cross-reference of the domination of pathogen.If protracted course of disease, involve in kidney, its pathogenesis then presents kidney and loses and take the photograph and receive, the time of the excess of the lung of suffering from a deficiency of the kidney of expectorant stasis of blood volt lung.If deficient and weak YANG QI, water without lead, pathogenic water overflows, and can go up again icepro cardiopulmonary, and pathogenesis is then excess caused by deficiency, deficient and excessive syndromes appearing together.Chinese veterinarian's categorical identification in terms of causes of disease can be divided into four types: wind cold type cough: morbidity is comparatively anxious, tachypnea, with cough, and rhinorrhea with clear discharge, ophthalmic has spumescence secretions, and tracheal strips sends grunt, eyelid swelled, and fear of cold squeezes heap; Phlegm-heat type cough with asthma: morbidity is comparatively anxious, coughs dry and comfortable, xerostomia fever of the body, cough sound pitch and out of breath, larynx has rale, stretches neck mouth breathing, and expired gas is scorching hot, the thick tears of nose stream, and the mucus of some coughs expectoration band blood often, some sputums block throat, trachea, cause death by suffocation.Arrange green loose stool, some calculus ash water sample loose stools, amount of drinking water increases; Summer-wet type cough with asthma: summer summer heat in season, long summer dampness for contain.When the heresy of heat-damp in summer invades chicken body, suffer from chicken performance spirit depressed, breathe out, some appearance are coughed or are had trachea rale, loss of appetite, and drink increases severely in advance, and crop swells, and has loose bowels, and growth of meat chicken is stagnated, and laying hen egg production declines; Void is coughed: mostly be obstinate disease, and it is faint to suffer from chicken, inappetence, exhales to inhale few more, even dynamic then breathe heavily and have cough, but sound is low, short.
In recent years, the respiratory tract disease of chicken is at home in local popular, and general sickness rate is 30% ~ 40%, and main manifestations is dyspnea, coughs, stridulates.Infect this after being ill, chick growth is slow or stagnate, and laying hen egg yield significantly declines, and Mortality phenomenon appears in some morbidity chicken group, causes serious harm, cause larger economic loss to poultry husbandry.The pathogenetic reason of chicken respiratory is very complicated, the transmitted pathogens such as virus, antibacterial, Mycoplasma and air unclean, the environmental factorss such as temperature cataclysm are relevant, bring very large difficulty to clinical definite and control.Treat with vaccine prevention and chemicals and antibiotic etc. this disease is main at present, its effect is undesirable.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of and has expectorant cough suppressant and anti-asthmatic, the medicine being used for the treatment of chicken wind-cold type cough of the curative effect of the cold expelling that induces sweat, and has good effect, short treating period, the advantage that has no side effect at treatment chicken wind and cold cough.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine being used for the treatment of chicken wind-cold type cough with asthma, described medicine comprises following raw medicinal material: the Rhizoma Pinelliae, Poria, Rhizoma Zingiberis Recens, Fructus Gleditsia, Fructus Perillae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Sinapis Albae, Radix Platycodonis, Extract Carnis Bovis, Semen Benincasae, Folium Perillae, Cacumen Tamaricis, Semen Armeniacae Amarum, Flos Inulae, Rhizoma Cynanchi Stauntonii, adenostemma laveniaKuntze, gray gum, Herba Centipedae, platform mushroom, Exocarpium Citrulli, Herba Schizonepetae, Ou Zeqin, Radix Saposhnikoviae and Radix Glycyrrhizae.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion and Radix Glycyrrhizae 10-30 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 13-16 weight portion, Poria 19-23 weight portion, Rhizoma Zingiberis Recens 14-21 weight portion, Fructus Gleditsia 12-17 weight portion, Fructus Perillae 12-15 weight portion, Pericarpium Citri Reticulatae 23-28 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Semen Sinapis Albae 12-16 weight portion, Radix Platycodonis 13-19 weight portion, Extract Carnis Bovis 10-15 weight portion, Semen Benincasae 14-20 weight portion, Folium Perillae 14-19 weight portion, Cacumen Tamaricis 12-18 weight portion, Semen Armeniacae Amarum 13-17 weight portion, Flos Inulae 13-20 weight portion, Rhizoma Cynanchi Stauntonii 13-18 weight portion, adenostemma laveniaKuntze 16-25 weight portion, gray gum 13-21 weight portion, Herba Centipedae 13-20 weight portion, platform mushroom 10-16 weight portion, Exocarpium Citrulli 10-14 weight portion, Herba Schizonepetae 14-20 weight portion, Ou Zeqin 13-19 weight portion, Radix Saposhnikoviae 13-18 weight portion and Radix Glycyrrhizae 15-23 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portion, Poria 21 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Fructus Gleditsia 14 weight portion, Fructus Perillae 14 weight portion, Pericarpium Citri Reticulatae 25 weight portion, Cortex Magnoliae Officinalis 20 weight portion, Semen Sinapis Albae 14 weight portion, Radix Platycodonis 16 weight portion, Extract Carnis Bovis 13 weight portion, Semen Benincasae 16 weight portion, Folium Perillae 16 weight portion, Cacumen Tamaricis 15 weight portion, Semen Armeniacae Amarum 15 weight portion, Flos Inulae 17 weight portion, Rhizoma Cynanchi Stauntonii 14 weight portion, adenostemma laveniaKuntze 21 weight portion, gray gum 16 weight portion, Herba Centipedae 17 weight portion, platform mushroom 13 weight portion, Exocarpium Citrulli 12 weight portion, Herba Schizonepetae 17 weight portion, Ou Zeqin 16 weight portion, Radix Saposhnikoviae 15 weight portion and Radix Glycyrrhizae 17 weight portion.
Described medicine preferably also comprises: rein in the horse back, Herba tetragoniae, Rhizoma Dioscoreae, Ganoderma and Fructus Crataegi.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion, Radix Glycyrrhizae 10-30 weight portion, to rein in the horse back 10-20 weight portion, Herba tetragoniae 10-20 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Ganoderma 15-30 weight portion and Fructus Crataegi 10-15 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portion, Poria 20 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Fructus Gleditsia 15 weight portion, Fructus Perillae 14 weight portion, Pericarpium Citri Reticulatae 25 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Semen Sinapis Albae 15 weight portion, Radix Platycodonis 14 weight portion, Extract Carnis Bovis 14 weight portion, Semen Benincasae 15 weight portion, Folium Perillae 16 weight portion, Cacumen Tamaricis 15 weight portion, Semen Armeniacae Amarum 15 weight portion, Flos Inulae 15 weight portion, Rhizoma Cynanchi Stauntonii 14 weight portion, adenostemma laveniaKuntze 20 weight portion, gray gum 17 weight portion, Herba Centipedae 15 weight portion, platform mushroom 15 weight portion, Exocarpium Citrulli 14 weight portion, Herba Schizonepetae 17 weight portion, Ou Zeqin 14 weight portion, Radix Saposhnikoviae 15 weight portion, Radix Glycyrrhizae 20 weight portion, to rein in the horse back 15 weight portions, Herba tetragoniae 15 weight portion, Rhizoma Dioscoreae 21 weight portion, Ganoderma 21 weight portion and Fructus Crataegi 12 weight portion.
Present invention also offers a kind of preparation method being used for the treatment of the medicine of chicken wind-cold type cough to better realize foregoing invention object, described preparation method comprises the following steps:
Step one, all raw medicinal materials are dropped in proportion in blender stir, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 5 ~ 7 times amount water, boil 2 ~ 4 hours, steam pressure is 0.6 ~ 1Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 5 ~ 7 times amount water, boil 2 ~ 4 hours, steam pressure is 0.6Mpa ~ 1Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain drug powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention has expectorant cough suppressant and anti-asthmatic, the curative effect of the cold expelling that induces sweat, have evident in efficacy at treatment chicken wind-cold type cough, side effect is low, the advantages such as cure rate is high, short treating period, not easily recurrence.
Detailed description of the invention
Embodiments provide a kind of medicine being used for the treatment of chicken wind-cold type cough, comprise following raw medicinal material: the Rhizoma Pinelliae, Poria, Rhizoma Zingiberis Recens, Fructus Gleditsia, Fructus Perillae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Sinapis Albae, Radix Platycodonis, Extract Carnis Bovis, Semen Benincasae, Folium Perillae, Cacumen Tamaricis, Semen Armeniacae Amarum, Flos Inulae, Rhizoma Cynanchi Stauntonii, adenostemma laveniaKuntze, gray gum, Herba Centipedae, platform mushroom, Exocarpium Citrulli, Herba Schizonepetae, Ou Zeqin, Radix Saposhnikoviae and Radix Glycyrrhizae; Preferably, medicine preferably also comprises: rein in the horse back, Herba tetragoniae, Rhizoma Dioscoreae, Ganoderma and Fructus Crataegi.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The Rhizoma Pinelliae: pungent, temperature, poisonous; Enter lung, spleen, stomach three warp." property of medicine opinion ": " anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot for expectorant saliva, appetite promoting and the spleen strengthening." " Japan hanako materia medica ": " control and tell food regurgitation, cramp caused by acute vomiting and diarrhea, intestinal abdomen is cold, intermittent fever due to phlegm." the pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cured mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, controlled again the dizzy palpitation and insomnia that damp-phlegm is violated, and also can control wind-phlegm and tell inverse, headache limb fiber crops, hemiplegia, the diseases such as facial hemiparalysis.
Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.
Rhizoma Zingiberis Recens: Rhizoma Zingiberis Recens refers to the tuber stem of ginger, calls purple Rhizoma Zingiberis Recens, Rhizoma Zingiberis Recens, fresh ginger, old ginger.Warm in nature, its distinctive " gingerol " energy stimulating gastrointestinal mucosa, make gastrointestinal redness, digestion power strengthens, and effectively can treat the abdominal distention, stomachache, diarrhoea, vomiting etc. of eating cold and cool food and too much causing.After eating Rhizoma Zingiberis Recens, people has the sensation of body heat, this is because it can distend the blood vessels, blood circulation is accelerated, and impels pore with it to open, so not only the unnecessary torrid zone can be walked, also the pathogenic bacteria in body, cold are together taken out of simultaneously.When health has eaten cold and cool thing, be subject to drench with rain or stay in air-conditioned room long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because human body is trembled with fear the various discomforts remake.
Fructus Gleditsia: pungent, temperature; Enter lung, Liver Channel.Compendium of Material Medica: " Fructus Gleditsia acupuncture controls wind parasite killing, and merit and pod are with, the different ear but its sharp keen through disease is done." containing flavonoid glycoside, phenols, aminoacid.Flavone compound is fustin (fustin i.e. 3,7,3,4-tetrahydroxy flavanones), fisetin (fisetin i.e. 3,7,3,4-kaempferols), and containing leucocyanidin.Experiment in vivo, has the effect of inhibit activities to turbid Mus S-180.Decoct flat board burrows method, has inhibitory action to staphylococcus aureus and micrococcus catarrhalis; Water logging agent 60g/kg gavage is 32.8% to the suppression ratio of S-180.Fructus Gleditsia, for attacking loose high strict product, is not broken without heavily fortified point, does not fall apart without expectorant, and energy switch intestinal stasis relieving, to unconsciousness due to blockage of phlegm disease with it, can help meet an urgent need.Outer infections head is outstanding, and will burst when not bursting, utilize Fructus Gleditsia to break through its head, to cut for cutter, defeated and dispersed power is quite strong.
Fructus Perillae: pungent, temperature.Return lung, large intestine channel." book on Chinese herbal medicine converge ": " Fructus Perillae, loose gas is very prompt, can the upper and lower all gas of profit clearly, and Dingchuan expectorant is meritorious, and can lead to two just, except anemofrigid-damp arthralgia.If the deficiency of vital energy and fullness in the chest person, also unavailable, or to hold concurrently Shi Yike with tonic." " Japan hanako materia medica ": " and in homophony, beneficial the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, only cholera, vomiting, regurgitation, tonify deficiency labor, fertile strong people, sharp defecation, broken knot, disappear five every, antitussive, profit ambition, eliminating phlegm-retention." sending down the abnormal ascending QI expectorant, relieving cough and asthma, loosening bowel to relieve constipation.QI rising in reverse order is stopped up, cough and asthma, dryness of the intestine constipation for expectorant.Feed chicken with the feedstuff containing perilla oil, chicken plasma cholesterol levels can be made to reduce, all have inhibitory action to the mycete of Bacillus proteus, Aspergillus niger, penicillium and occurring in nature, the ethanol extraction after defat has anticorrosion and antioxidation.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Energy regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Temperature can circulation of qi promoting, pungently can disperse, bitter and sluice.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Pericarpium Citri tangerinae goes its words spoken by an actor from offstage person, is referred to as Exocarpium Citri Rubrum, and its arduous taste is heavier, therefore is clinically mainly used on damp eliminating reduces phlegm, when especially abundant expectoration stops up lung, as conventional patent medicine Juhong Wan and so on.Vascular aurantii has row QI of channels and collaterals, goes the effect of meridians phlegm-damp, therefore when being used in the numb limbs and tense tendons of stagnation of QI causing phlegm retention clinically, polygamy is among other Cheng Fang.The effect that Semen Citri Reticulatae has removing obstruction for relieving pain to dry to reduce phlegm, therefore clinically for hernia pain, the wet main numbness lumbago of Epileptic etc.Folium Citri tangerinae color is blue or green, have bar to reach the effect of irritability, therefore clinically for the pain over the hypochondriac region, when mastalgia uncomfortable in chest, also polygamy uses at Cheng Fangzhong.Cortex Magnoliae Officinalis: bitter, pungent, warm in nature; Return spleen channel, stomach warp, large intestine channel.Function: circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively cause saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and have stomach invigorating digestion-aid effect.Experiment in vitro proves, Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis. and experiment shows, compare with other 61 kinds of Chinese medicines, the effect of Cortex Magnoliae Officinalis to Staphylococcus albus, bacillus subtilis, escherichia coli and Bacillus typhi is the strongest.It act as bactericidal action to Staphylococcus albus and bacillus subtilis.
Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Enter the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus." Japan hanako materia medica ": " control the swollen and paralysis of pathogenic wind toxic, vinegar grind Fu it.Flutter damage blood stasis, lumbago kidney cold-peace Rhizoma Zingiberis Recens grinds, micro-warm, is coated with and pastes.Pained, wine vinegar takes it." Compendium of Material Medica: " Semen Sinapis Albae is pungent can enter lung, and temperature can be dispersed, therefore has the merit of the appetizing of promoting the circulation of QI eliminating phlegm, warming middle-JIAO, loose evil of bitterly subsiding a swelling, ward off." cold air can be removed, settling five organs, by the expectorant of film diaphragm, ward off stealthy gas, the addiction that disappears malaria, drop interests Dingchuan, sharp key improving eyesight, and removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, outstanding kind receipts merit.Mustard flour is used as flavoring agent, and salivation and amylase activity are increased, and heart size and heart rate are reduced.
Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " is said: " main chest and hypochondrium as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.
Extract Carnis Bovis: sweet in the mouth; Warm in nature.Return spleen channel.Function cures mainly: strengthening the spleen and stomach; Fill blood; Moistening the lung and resolving the phlegm.Main asthenia is won thin; Apoplexy is attached undue importance to one thing to the neglect of the other; Phlegm retention painful abdominal mass is amassed; Skin sucutaneous nodule.
Semen Benincasae: feeble QI, taste is micro-sweet.Control phlegm-heat cough, lung abscess, acute appendicitis, gonorrhea, edema, beriberi, hemorrhoid, nasal surface wine Zha.After Semen Benincasae water extraction, through dialyzed solution of dialysing to obtain, split agent for B cell causes silk, have clonal B cell activator activity and adjuvanticity, plaque forming cells can be made to keep count of and significantly increase, present immunologic enhancement.From Semen Benincasae, separation and purification goes out 4 components, has the effect suppressing trypsin vigor.
Folium Perillae: acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.Be applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Folium Perillae Herb all has very high nutritive value, and it has low sugar, high microsteping, high carotene, high mineral element etc.Containing perillaldehyde, perilla alcohol, menthone, menthol, eugenol, ergomaketon etc. in volatile oil.Defying age element SOD in every milligram of Folium Perillae content up to 106.2 micrograms.Find after deliberation, the each position of Folium Perillae evenly has good antitumaous effect, especially stronger with the effect in blade, oleanolic acid is wherein a kind of very strong natural anti-cancer agent, there is the effect of prophylaxis of tumours, there is again the effect of antiinflammatory, calmness, heart tonifying, diuresis, enhancing immunity, blood fat reducing and resistance growth of cancer cells.Folium Perillae can diaphoresis cold expelling to separate pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, therefore doublely to wind and cold table disease see symptoms of emesis uncomfortable in chest, use this product, be very suitable; Or the smooth symptom of the stagnation of QI is had without table disease, also can be used for a surname logical.
Cacumen Tamaricis: sweet, pungent, flat.GUIXIN, lung, stomach warp.Function cures mainly: loose wind, induces sweat, rash.For measles without adequate eruption, rheumatic arthralgia.
Semen Armeniacae Amarum: bitter, tepor; Slightly poisonous." Mingyi Bielu ": " almond core, May adopts it.Its two core person kills a person, can malicious Canis familiaris L..Raw Jin Shanchuangu." Shennong's Herbal: " main cough with dyspnea is thundered, sore throat, the therapeutic method to keep the adverse QI flowing downwards, galactopoiesis incised wound, bitterly disappointed renal mass." " property of medicine opinion ": " control abdomen numbness obstructed, diaphoresis, main epidemic febrile disease.Control spasm in the epigastrium completely pain, except trusted subordinate is unhappy, treat lung qi cough, dyspnea.Enter Radix Asparagi to decoct, profit cardiopulmonary.Soup can be made, benefit profit information with cheese.Place i.e. dynamic cold air." relieving cough and asthma, loosening bowel to relieve constipation.Collective Notes to the Canon of Materia medica: " obtain fiery good.Dislike Radix Astragali, Radix Scutellariae, Radix Puerariae.Wei Folium Zingiberis miogae." the bitter warm lung qi dispersing of Semen Armeniacae Amarum, loosening bowel to relieve constipation, be only suitable for the trouble of the excess syndrome such as ailment said due to cold or exposure, dryness of the intestine.All the moon loses, stagnated fire person, then should not take orally for a long time by single medicinal material.As the disease taboo single medicinal materials such as pulmonary tuberculosis, bronchitis, chronic enteritis, dry cough without phlegm take for a long time.Correct edible Semen Armeniacae Amarum, can reach promoting the production of body fluid to quench thirst, lung moistening Dingchuan, laxation relieving constipation, reduce effect of intestinal cancer.
Flos Inulae: salty, warm, slightly poisonous; Enter lung, liver, stomach warp.Function expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water." herbal classic ": " main stagnation of QI, fullness in the hypochondrium, palpitation with fear.Dewater, remove cold and heat between the five internal organs, invigorating middle warmer, the therapeutic method to keep the adverse QI flowing downwards." " property of medicine opinion ": " main rib side of body gas, lower cold and heat edema, cures mainly bladder retained water, goes by large abdomen, appetizing, the inverse not lower food of preventing or arresting vomiting." cure mainly expectorant knot in the heart, the lower distension of the side of body, cough with asthma, singultus, saliva as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.Chlorogenic acid has sensitization to people, sucks (as in coffee plant) after the dust of the plant containing chlorogenic acid, can pant, dermatitis etc., but can through the effect of intestinal secretion thing after eating, become without allergenic substance, therefore during test sensitinogen, Intradermal method should be used and without oral medication." Amplification on Materia Medica addendum ": " patient relates to empty person and should not take more, and sharp large intestine, guards against it.”
Rhizoma Cynanchi Stauntonii: pungent, bitter, tepor; Return lung meridian.. Tang Materia Medica: " Rhizoma Cynanchi Stauntonii, Ye Siliu, or like Flos Genkwa, height of seedling chi is permitted, on the desert of a raw small piece of land surrounded by water, continent.Root is white, is longer than Herba Asari, sweet in the mouth.Custom takes with wine stain, Zhu Shangqi.Not raw shortcut.The present uses climing survivor, bitter in the mouth, and non-real also.". " herbal classic is met former ": " Rhizoma Cynanchi Stauntonii, comparatively Radix Cynanchi Atrati is slightly warm, and comparatively Herba Asari is slightly flat.Specially search edema due to wind pathogen in lung key, if non-Radix Cynanchi Atrati is salty-cold, specially let out lung, stomach scorching, also do not alter like the pungent of Herba Asari, can control kidney, liver heavy cold also." lowering the adverse-rising QI to resolve phlegm, cough-relieving.Cough with copious phlegm, asthma.This product slightly warm in nature and not dry strong, is longer than and eliminates the phlegm, fall lung qi with flat cough with asthma.No matter genus is cold belongs to heat, Exogenous and internal injuries, chronic cough of newly coughing all available it.
Adenostemma laveniaKuntze: bitter, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For high heat of catching a cold, bronchitis, pharyngolaryngitis, tonsillitis, icterohepatitis; Carbuncle furuncle infections is controlled in external, venom.
Gray gum: pungent, micro-hardship, temperature.Function cures mainly: anti-inflammation and sterilization, expelling phlegm for arresting cough, convergence parasite killing.For preventing influenza, epidemic encephalitis type B.Prevent and treat malaria, enteritis, diarrhoea, dysentery, skin ulceration, carbuncle skin ulcer is red and swollen, erysipelas, mastitis, trauma infection contamination, tinea, neurodermatitis.Also can control leptospirosis, tracheitis, cough, maggot, smoked mosquito can be killed.
Herba Centipedae: energy dispersing wind-cold, clearing the nasal passage, cough-relieving, removing toxic substances, antipruritic." book on Chinese herbal medicine converges and says " cloud: " medicine of stuffy nose relieving gas also for Herba Centipedae, sharp nine orifices.Its acrid in the mouth is strong, and its gas is pungent smoked, and its property rises loose, can lead to lung meridian, above reach brains, therefore the phlegm dyspnea of main Snore clam, gas-tight obstructed, nasal polyp of having a stuffy nose, and feeling of distension and oppression is unfavorable, goes cataracta in order, and cold-evil, all diseases of wind syndrome of head headache in head, all get the loose merit of pungent temperature rise also ".Cough-relieving, antiasthmatic effect: this product volatile oil and ethanol extract part have cough-relieving, eliminate the phlegm, antiasthmatic effect.Volatile oil and ethanol extract part have some cough-relieving, eliminate the phlegm, antiasthmatic effect, and sediment fraction cough suppressing effect is not obvious, without phlegm-dispelling functions.Experiment in vitro, decoct has inhibitory action to tubercule bacillus.Herb extract have obvious inhibitory action to beta-hydroxy-Beta-methyl 1,3-propanedicarboxylic acid (HMG) coenzyme A, calcium channel blocker and gallbladder contraction.
Platform mushroom: micro-salty, temperature.Function cures mainly: chase after wind, cold expelling, and relaxing muscles and tendons is active.For lumbago and skelalgia, numb hand and foot, grain does not relax.
Exocarpium Citrulli: sweet, light, cold.Be included into the heart, stomach warp.Function cures mainly+clearing away summer-heat, relieving restlessness of purging heat, diuresis.For summer-heat excessive thirst, oliguria with reddish urine, laryngopharynx swelling and pain, or aphtha of the mouth and tongue, the diseases such as edema.
Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet; Enter lung, Liver Channel." Japan hanako materia medica ": " sharp the five internal organs, removing stagnancy of indigested food and making QI downward, relieving alcoholic intoxication.Heat-dissipating of cooking is eaten and is simmered tea, and controls wind syndrome of head and antiperspirant goes out; Semen Glycines preparatum decoct control violent trauma tremble with fear." " detailed outline ": " throat, the skin ulcer that disappears swells for loose wind heat, refresh oneself.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.Make fever in rabbits with typhoid fever polyvalent vaccine, give Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, find that there is faint refrigeration function.Herba Schizonepetae oil can reduce normal rat body temperature; Also have sedation, Herba Schizonepetae oil (0.5ml/kg) is to rabbit gavage, and its movable minimizing as seen, limb muscle is slightly lax.Herba Schizonepetae oil can obviously extend acetylcholine and histamine mixed liquor causes the incubation period of breathing heavily to Cavia porcellus, reduces the number of animals occurring to twitch; The guinea pig tracheal smooth muscle that also can cause anti-acetylcholine or histamine is shunk; Still there is phlegm-dispelling functions.
Ou Zeqin: sweet in the mouth; Property is put down.Function cures mainly: wind-expelling pain-stopping; Blood pressure lowering.Main flu; Headache; Hypertension.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Enter urinary bladder channel, lung meridian, spleen channel, Liver Channel." Japan hanako materia medica ": " control wind as 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, and arresting lacrimation and paralysis delay, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." " Changsha medicine solution ": " network of passing through, by wet excessive, gets round by bribery, and relieve the pain pain, relaxing muscles and tendons arteries and veins, stretches anxious twin, podomere of living, and plays paralysis, holds back spontaneous perspiration, night sweat, break, metrorrhagia." function expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, and stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.Deficiency of YIN-blood, calentura wind symptom person should not use, and blood deficiency convulsion is anxious or have a headache not because ailment said due to cold or exposure person avoids clothes.
Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.
Rein in the horse back: bitter, cold.Function cures mainly: lung heat clearing, reduces phlegm, cough-relieving, removing toxic substances.For chronic tracheitis, pulmonary suppuration disease, coughs vomiting bloody pus; Hemorrhoid are controlled in external, skin eczema, and rubella is scratched where it itches, furuncle carbuncle skin infection.
Herba tetragoniae: sweet; Micro-pungent; Property is put down.Return lung; Liver; Large intestine channel.Function cures mainly: wind and heat dispersing; Removing toxic substances and promoting subsidence of swelling.The hot conjunctival congestion of main air; Treatment skin ulcer swells and ache; Intestinal is scorching; Septicemia; Tumor.
Rhizoma Dioscoreae: sweet in the mouth, property are flat, enter lung, spleen, kidney channel; Not dry oiliness, have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red disease such as swollen, fat of frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.Compendium of Material Medica summary five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, reduce phlegm saliva, profit skin ".Rhizoma Dioscoreae cook congee or with crystal sugar simmer ripe after take, poor to health, colitis, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treat weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, and sweet in the mouth matter is moistened, that can treat that lung suffers from a deficiency of the kidney and damage quenches one's thirst, passes out semen, is with inferior disease.Be described as angle's medicine.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, enters spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, be mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi be the staple for the treatment of dyspepsia, and Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; To dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus etc., there is obvious inhibitory action.
Described medicine is made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion and Radix Glycyrrhizae 10-30 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 13-16 weight portion, Poria 19-23 weight portion, Rhizoma Zingiberis Recens 14-21 weight portion, Fructus Gleditsia 12-17 weight portion, Fructus Perillae 12-15 weight portion, Pericarpium Citri Reticulatae 23-28 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Semen Sinapis Albae 12-16 weight portion, Radix Platycodonis 13-19 weight portion, Extract Carnis Bovis 10-15 weight portion, Semen Benincasae 14-20 weight portion, Folium Perillae 14-19 weight portion, Cacumen Tamaricis 12-18 weight portion, Semen Armeniacae Amarum 13-17 weight portion, Flos Inulae 13-20 weight portion, Rhizoma Cynanchi Stauntonii 13-18 weight portion, adenostemma laveniaKuntze 16-25 weight portion, gray gum 13-21 weight portion, Herba Centipedae 13-20 weight portion, platform mushroom 10-16 weight portion, Exocarpium Citrulli 10-14 weight portion, Herba Schizonepetae 14-20 weight portion, Ou Zeqin 13-19 weight portion, Radix Saposhnikoviae 13-18 weight portion and Radix Glycyrrhizae 15-23 weight portion.
Described medicine can also be made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portion, Poria 21 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Fructus Gleditsia 14 weight portion, Fructus Perillae 14 weight portion, Pericarpium Citri Reticulatae 25 weight portion, Cortex Magnoliae Officinalis 20 weight portion, Semen Sinapis Albae 14 weight portion, Radix Platycodonis 16 weight portion, Extract Carnis Bovis 13 weight portion, Semen Benincasae 16 weight portion, Folium Perillae 16 weight portion, Cacumen Tamaricis 15 weight portion, Semen Armeniacae Amarum 15 weight portion, Flos Inulae 17 weight portion, Rhizoma Cynanchi Stauntonii 14 weight portion, adenostemma laveniaKuntze 21 weight portion, gray gum 16 weight portion, Herba Centipedae 17 weight portion, platform mushroom 13 weight portion, Exocarpium Citrulli 12 weight portion, Herba Schizonepetae 17 weight portion, Ou Zeqin 16 weight portion, Radix Saposhnikoviae 15 weight portion and Radix Glycyrrhizae 17 weight portion.
Described medicine preferably also comprises: rein in the horse back, Herba tetragoniae, Rhizoma Dioscoreae, Ganoderma and Fructus Crataegi.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion, Radix Glycyrrhizae 10-30 weight portion, to rein in the horse back 10-20 weight portion, Herba tetragoniae 10-20 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Ganoderma 15-30 weight portion and Fructus Crataegi 10-15 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portion, Poria 20 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Fructus Gleditsia 15 weight portion, Fructus Perillae 14 weight portion, Pericarpium Citri Reticulatae 25 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Semen Sinapis Albae 15 weight portion, Radix Platycodonis 14 weight portion, Extract Carnis Bovis 14 weight portion, Semen Benincasae 15 weight portion, Folium Perillae 16 weight portion, Cacumen Tamaricis 15 weight portion, Semen Armeniacae Amarum 15 weight portion, Flos Inulae 15 weight portion, Rhizoma Cynanchi Stauntonii 14 weight portion, adenostemma laveniaKuntze 20 weight portion, gray gum 17 weight portion, Herba Centipedae 15 weight portion, platform mushroom 15 weight portion, Exocarpium Citrulli 14 weight portion, Herba Schizonepetae 17 weight portion, Ou Zeqin 14 weight portion, Radix Saposhnikoviae 15 weight portion, Radix Glycyrrhizae 20 weight portion, to rein in the horse back 15 weight portions, Herba tetragoniae 15 weight portion, Rhizoma Dioscoreae 21 weight portion, Ganoderma 21 weight portion and Fructus Crataegi 12 weight portion.
Described preparation method comprises the following steps:
Step one, all raw medicinal materials are dropped in proportion in blender stir, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 5 ~ 7 times amount water, boil 2 ~ 4 hours, steam pressure is 0.6 ~ 1Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 5 ~ 7 times amount water, boil 2 ~ 4 hours, steam pressure is 0.6Mpa ~ 1Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain drug powder.
Embodiment 1 medicine 1
Embodiments provide a kind of medicine being used for the treatment of chicken wind-cold type cough, be made up of the raw medicinal material of parts by weight: the Rhizoma Pinelliae 15 weight portion, Poria 21 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Fructus Gleditsia 14 weight portion, Fructus Perillae 14 weight portion, Pericarpium Citri Reticulatae 25 weight portion, Cortex Magnoliae Officinalis 20 weight portion, Semen Sinapis Albae 14 weight portion, Radix Platycodonis 16 weight portion, Extract Carnis Bovis 13 weight portion, Semen Benincasae 16 weight portion, Folium Perillae 16 weight portion, Cacumen Tamaricis 15 weight portion, Semen Armeniacae Amarum 15 weight portion, Flos Inulae 17 weight portion, Rhizoma Cynanchi Stauntonii 14 weight portion, adenostemma laveniaKuntze 21 weight portion, gray gum 16 weight portion, Herba Centipedae 17 weight portion, platform mushroom 13 weight portion, Exocarpium Citrulli 12 weight portion, Herba Schizonepetae 17 weight portion, Ou Zeqin 16 weight portion, Radix Saposhnikoviae 15 weight portion and Radix Glycyrrhizae 17 weight portion.
Preparation method is as follows:
Step one, all raw medicinal materials are dropped in proportion in blender stir, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 6 times amount water, boil 3 hours, steam pressure is 0.8Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 6 times amount water, boil 3 hours, steam pressure is 0.8Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain drug powder.
Embodiment 2 medicine 2
Embodiments provide a kind of medicine being used for the treatment of chicken wind-cold type cough, be made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portion, Poria 20 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Fructus Gleditsia 15 weight portion, Fructus Perillae 14 weight portion, Pericarpium Citri Reticulatae 25 weight portion, Cortex Magnoliae Officinalis 18 weight portion, Semen Sinapis Albae 15 weight portion, Radix Platycodonis 14 weight portion, Extract Carnis Bovis 14 weight portion, Semen Benincasae 15 weight portion, Folium Perillae 16 weight portion, Cacumen Tamaricis 15 weight portion, Semen Armeniacae Amarum 15 weight portion, Flos Inulae 15 weight portion, Rhizoma Cynanchi Stauntonii 14 weight portion, adenostemma laveniaKuntze 20 weight portion, gray gum 17 weight portion, Herba Centipedae 15 weight portion, platform mushroom 15 weight portion, Exocarpium Citrulli 14 weight portion, Herba Schizonepetae 17 weight portion, Ou Zeqin 14 weight portion, Radix Saposhnikoviae 15 weight portion, Radix Glycyrrhizae 20 weight portion, to rein in the horse back 15 weight portions, Herba tetragoniae 15 weight portion, Rhizoma Dioscoreae 21 weight portion, Ganoderma 21 weight portion and Fructus Crataegi 12 weight portion.
Described preparation method comprises the following steps:
Step one, all raw medicinal materials are dropped in proportion in blender stir, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 6 times amount water, boil 3 hours, steam pressure is 0.8Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 6 times amount water, boil 3 hours, steam pressure is 0.8Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain drug powder.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, each 10 of hero, with the medicine of the embodiment of the present invention 1 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.With the Chinese medicine additive of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
2, acute toxicity test
Application NIH mice 40, SPF level, male and female half and half, body weight 16 ~ 20g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore the acute toxicity of the medicine of the embodiment of the present invention 1 is low, clinical drug safety.With the medicine of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
Contrast test
In December, 2012, the AA broiler morbidity of 1500 21 ages in days of Tai'an, Shandong Province poultry smallholder operating, fall ill two days nearly 1/3rd chicken be originally stream nose, sneeze, ophthalmic have spumescence secretions, a couple of days, full chicken occurred that cough, dyspnea, tracheal strips send snore subsequently, feed intake obviously reduces, spirit is poor, is unwilling to walk about, and fear of cold squeezes heap.Pathology cuts open inspection: nasal cavity, tracheal strips have mucus, and air bag obviously thickens, and swelling around the eyes is swollen, can extrude lark grumeleuse.Wind-cold type cough is diagnosed as according to trouble chicken symptom and pathological change.
Select 600 ill chickens, be divided into three groups at random, embodiment group 1, embodiment group 2 and matched group.Embodiment group 1 uses the conventional feed being added with the embodiment of the present invention 1 medicine, and medicine accounts for 5% of feedstuff gross weight, uses 3-5 days; Embodiment group 2 uses the conventional feed being added with the embodiment of the present invention 2 medicine, and medicine accounts for 7% of feedstuff gross weight, uses 3-5 days; Matched group uses enrofloxacin and Buddha's warrior attendant to exhale larynx to seize by force powder and treats, and adds enrofloxacin 55g, Buddha's warrior attendant exhales larynx to seize by force powder 40g, use 3-5 days in every 1kg feedstuff.Test is 21 days, and treat according to different chicken symptom improvement situation, overall therapeutic, after 5 days, adds up the cure rate of ill chicken, effective percentage, inefficiency and mortality rate.Experimental result as shown in Table 1 and Table 2.
Treatment standard: all symptoms all disappear, appetite and spirit all recover normal, are recovery from illness; Breathe smooth and easy, tracheal strips snore is not obvious, cough with asthma symptom is clearly better, and appetite and spirit are recovered substantially, for effectively; All symptoms all do not change, even dead, for invalid; Wherein effective percentage is the percentage ratio that recovery from illness and effective sum account for sum.
Table 1 overall therapeutic is an effect synopsis % after 5 days
The each experimental group of table 2 to treat in 5 days recovery from illness and effective chicken and a time relatively %
Data from table 1 and table 2: medicine of the present invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Treat after five days simultaneously, effective chicken is continued to use medicine of the present invention to carry out treatment 1-3 days, effective chicken of embodiment group 1 and embodiment group 2 is all fully recovered, and within several days afterwards, continues to observe, and the chicken feed intake that embodiment group 1 and embodiment group 2 are fully recovered is higher than matched group; After experiment terminates, still grouping is fed to 42 ages in days and is delivered for sale, and result is added up, and in the chicken that embodiment group 1 and embodiment group are cured in 2 five days, relapse rate is respectively: 6.5% and 5.0%, and in the chicken that matched group was cured in five days, relapse rate is 36.4%.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (4)

1. be used for the treatment of the medicine of chicken wind-cold type cough, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion and Radix Glycyrrhizae 10-30 weight portion.
2. the medicine being used for the treatment of chicken wind-cold type cough according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 13-16 weight portion, Poria 19-23 weight portion, Rhizoma Zingiberis Recens 14-21 weight portion, Fructus Gleditsia 12-17 weight portion, Fructus Perillae 12-15 weight portion, Pericarpium Citri Reticulatae 23-28 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Semen Sinapis Albae 12-16 weight portion, Radix Platycodonis 13-19 weight portion, Extract Carnis Bovis 10-15 weight portion, Semen Benincasae 14-20 weight portion, Folium Perillae 14-19 weight portion, Cacumen Tamaricis 12-18 weight portion, Semen Armeniacae Amarum 13-17 weight portion, Flos Inulae 13-20 weight portion, Rhizoma Cynanchi Stauntonii 13-18 weight portion, adenostemma laveniaKuntze 16-25 weight portion, gray gum 13-21 weight portion, Herba Centipedae 13-20 weight portion, platform mushroom 10-16 weight portion, Exocarpium Citrulli 10-14 weight portion, Herba Schizonepetae 14-20 weight portion, Ou Zeqin 13-19 weight portion, Radix Saposhnikoviae 13-18 weight portion and Radix Glycyrrhizae 15-23 weight portion.
3. the medicine being used for the treatment of chicken wind-cold type cough according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portion, Poria 21 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Fructus Gleditsia 14 weight portion, Fructus Perillae 14 weight portion, Pericarpium Citri Reticulatae 25 weight portion, Cortex Magnoliae Officinalis 20 weight portion, Semen Sinapis Albae 14 weight portion, Radix Platycodonis 16 weight portion, Extract Carnis Bovis 13 weight portion, Semen Benincasae 16 weight portion, Folium Perillae 16 weight portion, Cacumen Tamaricis 15 weight portion, Semen Armeniacae Amarum 15 weight portion, Flos Inulae 17 weight portion, Rhizoma Cynanchi Stauntonii 14 weight portion, adenostemma laveniaKuntze 21 weight portion, gray gum 16 weight portion, Herba Centipedae 17 weight portion, platform mushroom 13 weight portion, Exocarpium Citrulli 12 weight portion, Herba Schizonepetae 17 weight portion, Ou Zeqin 16 weight portion, Radix Saposhnikoviae 15 weight portion and Radix Glycyrrhizae 17 weight portion.
4. the preparation method being used for the treatment of the medicine of chicken wind-cold type cough according to any one of claim 1-3, it is characterized in that, described preparation method comprises the following steps:
Step one, all raw medicinal materials are dropped in proportion in blender stir, mixing, pulverize in rear feeding pulverizer, the Chinese medicine composition after pulverizing is loaded in multi-function extractor, add relative to its quality 5 ~ 7 times amount water, boil 2 ~ 4 hours, steam pressure is 0.6 ~ 1Mpa process, filter, obtain the first filtrate and filtering residue;
Step 2, the filtering residue of acquisition added again relative to its quality 5 ~ 7 times amount water, boil 2 ~ 4 hours, steam pressure is 0.6Mpa ~ 1Mpa process, filter and obtain the second filtrate and filtering residue;
Step 3, the first filtrate and the second filtrate merged, concentrated removing moisture, obtains and gets dry extract, and adopts super-fine powder mill to pulverize, is crushed to less than 30 μm, obtain drug powder.
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