CN104922648A - Traditional Chinese medicine composite for treating chicken diarrhea and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composite for treating chicken diarrhea and a preparation method thereof and belongs to the technical field of traditional Chinese veterinary medicine. The traditional Chinese medicine composite is prepared with rhizoma zingiberis, folium mori, bighead atractylodes rhizome, fructus forsythiae, bupleurum falcatum, schizonepeta, rhizoma atractylodis, scutellaria baicalensis and white paeony roots. All ingredients of the traditional Chinese medicine composite cooperate with one another, no toxic or side effect exists, the use is safe, no drug resistance is generated, the composite is capable of resisting against bacteria and serving for sterilization, astringing the intestine, enhancing the body immunity, accelerating the growth and development of chickens, and a remarkable therapeutic effect in treating the chicken diarrhea is achieved.

Description

A kind of Chinese medicine composition for the treatment of chicken diarrhea and preparation method thereof

Technical field

The present invention relates to herbal medicine technical field, particularly a kind of Chinese medicine composition being used for the treatment of chicken diarrhea and preparation method thereof.

Background technology

Chicken diarrhea is the multiple common disease of a class, and this disease can make chicken loss of appetite, malnutrition, growth retardation or stagnation, some batterylaying is suffered from diarrhoea obstinate from upper cage, though open puerperal egg production to maintain medium level on the lower side, but heavy obviously decline of laying eggs, the economic benefit of impact poultry.As can be seen from a large amount of medical cases, chicken diarrhea roughly has two kinds of clinical manifestations: one is that feces is thinner, is commonly called as " having loose bowels "; One then based on draining sample loose stool, is commonly called as " drawing water ".

Cause chicken that the reason of diarrhoea occurs a lot, the factor of existing feeding and management aspect, also having drinking-water and feedstuff aspect, is then more chicken bacterial infectious disease, as chicken colibacillosis, salmonellosis of chicken, chicken cholera etc. can cause the diarrhoea of chicken.Current reply diarrhoea, Tri-Biocin determined curative effect is plant's common drug.But easily develop immunity to drugs, side effect is comparatively serious, and it is residual to have chemicals in Carnis Gallus domesticus and egg, brings potential threat to human health.

In recent years, pollution-free food is subject to people's favor gradually, and Chinese medicine, as the treatment of cultivated animals disease and prevention, has played more and more important effect, has been with a wide range of applications.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of chicken diarrhea and preparation method thereof.Chinese medicine composition therapeutic effect of the present invention is good, and have no side effect, cure rate is high, has the dual function for the treatment of and prevention.

For achieving the above object, the technical solution used in the present invention is as follows:

Treat a Chinese medicine composition for chicken diarrhea, described Chinese medicine composition is prepared from by Rhizoma Zingiberis, Folium Mori, the Rhizoma Atractylodis Macrocephalae, Fructus Forsythiae, Radix Bupleuri, Herba Schizonepetae, Rhizoma Atractylodis, Radix Scutellariae, the Radix Paeoniae Alba.

Preferably, the Chinese medicine composition of described treatment chicken diarrhea is prepared from by the medical material of following weight portion:

Rhizoma Zingiberis 30-60 Folium Mori 30-60 Rhizoma Atractylodis Macrocephalae 30-60

Fructus Forsythiae 10-30 Radix Bupleuri 30-60 Herba Schizonepetae 10-30

Rhizoma Atractylodis 10-30 Radix Scutellariae 30-60 Radix Paeoniae Alba 10-30.

Most preferably, the Chinese medicine composition of described treatment chicken diarrhea is prepared from by the medical material of following weight portion:

Rhizoma Zingiberis 45 Folium Mori 45 Rhizoma Atractylodis Macrocephalae 45

Fructus Forsythiae 20 Radix Bupleuri 30 Herba Schizonepetae 10

Rhizoma Atractylodis 15 Radix Scutellariae 45 Radix Paeoniae Alba 15.

The source of medical material of the present invention and pharmacological action:

Rhizoma Zingiberis: [source] this product is the dry rhizome of zingiber Zingiber officinale Rosc..Winter excavates, and removing fibrous root and silt, dry or cold drying.Take advantage of fresh slices to dry or cold drying person is called " dried ginger slice ".

[nature and flavor] are pungent, hot.

[return through] returns spleen, stomach, kidney, the heart, lung meridian.

[function cures mainly] Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.

Modern pharmacology confirms: Rhizoma Zingiberis has antiinflammatory, antibacterial, protozoacide effect.

Folium Mori: [source] this product is the dried leaves of moraceae plants Mulberry Morus alba L..Gather after first frost, removing impurity, dries.

[nature and flavor] are sweet, bitter, cold.

[return through] returns lung, Liver Channel.

[function cures mainly] dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.

Modern pharmacology confirms: Folium Mori have antibacterial action: Folium Mori decoct experiment in vitro, all there is stronger antibacterial action to staphylococcus aureus, beta hemolytic streptococcus, diphtheria corynebacterium and charcoal subcutaneous ulcer bacillus, also have certain antibacterial action to escherichia coli, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus.Decoct kills leptospiral effect in addition.

The Rhizoma Atractylodis Macrocephalae: [source] this product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Excavate when withered and yellow, the upper leaf of inferior leads in winter becomes fragile, removing silt, dries or dries, then remove fibrous root.

[nature and flavor] are bitter, sweet, temperature.

[return through] returns spleen, stomach warp.

[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Modern pharmacology confirms: Rhizoma Atractylodis Macrocephalae infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Decoct also has inhibitory action to meningococcus.Nearly report Rhizoma Atractylodis Macrocephalae decoct and decoction of four noble drugs all have bacteriostasis in various degree to Bacillus typhi, paratyphoid bacillus A, shigella flexneri, escherichia coli, bacillus pyocyaneus etc.

Fructus Forsythiae: [source] this product is the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Gather during fruit in autumn first ripe still band green, removing impurity, cooks, dries, and practises title " green grass or young crops sticks up "; Gather when fruit is well-done, dry, removing impurity, practises and claims " always sticking up ".

[nature and flavor] are bitter, are slightly cold.

[return through] returns lung, the heart, small intestine meridian.

[function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.

Modern pharmacology confirms: Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.

Radix Bupleuri: [source] this product is the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium Willd..Different by character, practise title " Radix Bupleuri " and " Radix Bupleuri Scorzonerifolii " respectively.Spring, Qiu Erji excavate, removing stem and leaf and silt, dry.

[nature and flavor] are bitter, are slightly cold.

[return through] returns liver, gallbladder meridian.

[function cures mainly] reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Modern pharmacology confirms that Radix Bupleuri has: 1. refrigeration function, and heavy dose of Radix Bupleuri decoct (5 grams crude drug/kilogram) or alcohol extractum (2.5 grams crude drug/kilogram) have refrigeration function to the rabbit of artificial fever.To the rabbit causing heating with typhoid fever mixed vaccine, oral decoct or preserved material (2 gs/kg), also have slight cooling effect.2. calm, analgesic activity.Saikoside is oral, has sedation (pole-jump test), and can extend the sleep of surround hexethal to mice; It has good analgesic activity and stronger antitussive action.3 antiinflammatory actions.Saikoside oral (600 mgs/kg) significantly can reduce dextran, the 5-hydroxy tryptamine edema of rat ankle.In subcutaneous granulation cyst (Oleum Tiglii and the cotton pellet method) test of rat, determine that saikoside has exudation, suppresses the effect of granuloma growth.

Herba Schizonepetae: [source] this product is the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Summer, season in autumn two, the flowers are in blossom to top, fringe green time tap, removing impurity, dry.

[nature and flavor] are pungent, tepor.

[return through] returns lung, Liver Channel.

[function cures mainly] induces sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.

Modern pharmacology confirms that Herba Schizonepetae has many-sided effect: 1. antipyretic effect: make fever in rabbits with typhoid fever polyvalent vaccine, gives Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, only have faint refrigeration function.Herba Schizonepetae decoct has antipyretic effect.D-menthone in Herba Schizonepetae is analgesic main component, and 3-methyl cyclohexanone also has analgesic activity.2. resisting pathogenic microbes effect: the in vitro tests of Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.Secondly certain inhibitory action is all showed to anthrax bacillus, group B streptococcus, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus, Bacillus tuberculosis etc.3. anastalsis: mice is pressed AkohobShi method and measures the bleeding time, rabbit capillary tube method measures clotting time, the bleeding stopping period of relatively more raw product Herba Schizonepetae and Herba Schizonepetae charcoal.Normal saline gavage all used by medicine, rabbit 2g/kg, and mice 5g/kg, compares with normal saline.Result shows, raw product Herba Schizonepetae obviously can not shorten the bleeding time, and Herba Schizonepetae charcoal then makes hemorrhage time shorten 72.6%; Raw product Herba Schizonepetae makes reduced clotting time 30%, and Herba Schizonepetae charcoal shortens 77.7%, illustrates that Herba Schizonepetae has anastalsis after parch to black.

Rhizoma Atractylodis: [source] this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Spring, Qiu Erji excavate, and removing silt, dries, hit fibrous root.

[nature and flavor] are pungent, bitter, temperature.

[return through] returns spleen, stomach, Liver Channel.

[function cures mainly] is drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.

Modern pharmacology confirms: volatile oil contained by Rhizoma Atractylodis has dispelling-wind invigorating stomach effect, and contained bitterness also has stomach invigorating, appetitive effect.Experiment proves the enterospasm that Rhizoma Atractylodis have obvious anti-parasympathetic nervous medium acetylcholine to cause.In addition, Rhizoma Atractylodis are also by resisting rat gastric ulcer caused by rat acute gastritis caused by hydrochloric acid and pylorus ligation to cholinolytic effect.

Radix Scutellariae: [source] this product is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and removing fibrous root and silt, hit rough bark after solarization, dry.

[nature and flavor] are bitter, cold.

[return through] returns lung, gallbladder, spleen, large intestine, small intestine meridian.

[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Modern pharmacology confirms that the Radix Astragali has many-sided effect: 1. antiinflammatory antiallergic action; 2. anti-microbial effect, Radix Scutellariae has wider antimicrobial spectrum, inhibitory action is all had in vitro to dysentery bacterium, diphtheria corynebacterium, bacillus pyocyaneus, staphylococcus, streptococcus, Diplococcus pneumoniae and meningococcus etc., larynx spraying done by decoct, also effective to meningitis bacillicarrier, even if to the staphylococcus aureus that the antibiotics such as penicillin have developed immunity to drugs, Radix Scutellariae is still belonged to responsive.To various skin pathogenic fungus, external also have suppression effect, and can kill leptospira; 3. refrigeration function; 4. blood pressure lowering, diuresis; 5. the effect of pair blood fat and blood glucose; 6. and gallbladder, spasmolysis; 7. sedation etc.

The Radix Paeoniae Alba: [source] this product is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Summer, Qiu Erji excavate, and clean, and remove end to end and radicula, put in boiling water after boiling rear removing crust or peeling and boil, dry.

[nature and flavor] are bitter, sour, are slightly cold.

[return through] returns liver, spleen channel.

The pain relieving of [function cures mainly] suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.

Modern pharmacology confirms that the Radix Paeoniae Alba has many-sided effect: 1. central inhibitory action; 2. spasmolysis; 3. antiinflammatory, antiulcer action; 4. improve body's immunity; 5. antibacterial action, the antibacterial action of the Radix Paeoniae Alba is stronger, antimicrobial spectrum is comparatively wide, has inhibitory action in various degree to staphylococcus aureus, Hemolytic streptococcus, Streptococcus viridans, streptococcus pneumoniae, Bacillus typhi, Bacillus paratyphosus B, dysentery bacterium, escherichia coli, bacillus pyocyaneus, Bacillus proteus, bordetella pertussis, vibrio cholera etc.The Radix Paeoniae Alba in vitro to trichophyton, Trichophyton concentricunm, permitted the dermatophytess such as blue achorion, Du's big belly microspore tinea bacterium difficult to understand, rust microspore tinea bacterium, ulotrichy microspore tinea bacterium, epidermophyton inguinale, epidermophyton rubrum and star-shaped nocardia and also had inhibitory action in various degree; 6. protect the liver and Detoxication.

The Chinese medicine composition that the present invention treats chicken diarrhea has 9 taste medical material compatibilities and forms, all medicines coordinate 5 to use, can mutually work in coordination with, interact, there is the effect of the antiviral of wide spectrum, antibacterial, fungus, spirillum etc., and to body, there is immunoloregulation function, the body drag of chicken body to pathogen can also be improved while effectively treating chicken diarrhea.

The Chinese medicine composition that the present invention treats chicken diarrhea can adopt the conventional method of pharmaceutical preparation to be prepared into the multiple dosage forms such as powder, powder, water preparation.The Chinese medicine composition that the present invention treats chicken diarrhea is preferably powder.

Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of chicken diarrhea, and concrete steps are as follows:

1) each raw material for standby is taken by weight;

2) step 1) pulverizing medicinal materials is crossed 20-40 mesh sieve, mix homogeneously;

3) by step 2) mixed medicated powder drops in extraction pot, and add the water of medical material weight 8-12 times amount, adding hydrochloric acid adjust pH is 2.0-4.0, soaks 4 hours;

4) first big fire steaming and decocting 1-2 hour, then temperature control to a 60 DEG C insulation leaches filtrate in 1.5 hours;

5) filtering residue adds initial medical material weight 4-8 times water gaging, and adjust pH is that 8.0-10.0, water temperature 80-100 DEG C of extraction leaches filtrate in 60 minutes;

6) combining step 4) and step 5) gained filtrate, adjust pH 6.5-7.3, leaves standstill 2-4 hour;

7) collect supernatant, concentrated, drying and crushing, to obtain final product.

Preparation method of the present invention a kind ofly imitates the extraction method that body harmonization of the stomach intestinal absorption utilizes function, and first pass acid is carried second time and carried with alkali, is more conducive to extraction and the absorption of effective ingredient.The present invention does not do the extraction of the single active ingredient of single flavour of a drug, and compound collecting more can embody the mass action of Traditional Chinese Medicine prescription, and what more meet tcm clinical practice " differential diagnosis in terms of eight principles " " monarch " examines visit theory.The extracting method that the present invention breaks traditions " water extract-alcohol precipitation ", for a long time, the fifties, degree of recognition was higher relatively so far in " water extract-alcohol precipitation " application, but extracting method that neither be definitely unified, as long as compound recipe extracts all use this method.And preparation method of the present invention is considered from biopharmaceutical angle, not only adhere to overall development sight " active blending constituent " of Chinese medicine but also " digestive tract absorption " characteristic of oral administration can be embodied.

Detailed description of the invention

Below in conjunction with specific embodiment, set forth the present invention further.But these embodiments are only limitted to the present invention instead of the further restriction to protection scope of the present invention are described.

embodiment 1

The preparation of powder of the present invention:

Prescription:

Rhizoma Zingiberis 45 Folium Mori 45 Rhizoma Atractylodis Macrocephalae 45

Fructus Forsythiae 20 Radix Bupleuri 40 Herba Schizonepetae 15

Rhizoma Atractylodis 15 Radix Scutellariae 45 Radix Paeoniae Alba 15

Preparation method:

1) each raw material for standby is taken by above-mentioned weight portion;

2) step 1) pulverizing medicinal materials is crossed 40 mesh sieves, mix homogeneously;

3) by step 2) mixed medicated powder drops in extraction pot, and add the water of medical material weight 12 times amount, adding hydrochloric acid adjust pH is 3.0, soaks 4 hours;

4) first 105 degrees Celsius of steaming and decoctings 1 hour, then temperature control to a 60 DEG C insulation leaches filtrate in 1.5 hours;

5) filtering residue adds initial medical material weight 6 times of water gagings, and adjust pH is 9.5, and water temperature 85 DEG C is extracted and leached filtrate in 60 minutes;

6) combining step 4) and step 5) gained filtrate, adjust pH 7.0, leaves standstill 4 hours;

7) collect supernatant, concentrated, drying and crushing, adds adjuvant, obtained powder.

embodiment 2

The preparation of granule of the present invention

Prescription:

Rhizoma Zingiberis 60 Folium Mori 45 Rhizoma Atractylodis Macrocephalae 60

Fructus Forsythiae 10 Radix Bupleuri 30 Herba Schizonepetae 10

Rhizoma Atractylodis 20 Radix Scutellariae 45 Radix Paeoniae Alba 20

Preparation method:

1) each raw material for standby is taken by above-mentioned weight portion;

2) step 1) pulverizing medicinal materials is crossed 40 mesh sieves, mix homogeneously;

3) by step 2) mixed medicated powder drops in extraction pot, and add the water of medical material weight 12 times amount, adding hydrochloric acid adjust pH is 3.0, soaks 4 hours;

4) first 105 degrees Celsius of steaming and decoctings 1 hour, then temperature control to a 60 DEG C insulation leaches filtrate in 1.5 hours;

5) filtering residue adds initial medical material weight 6 times of water gagings, and adjust pH is 9.5, and water temperature 85 DEG C is extracted and leached filtrate in 60 minutes;

6) combining step 4) and step 5) gained filtrate, adjust pH 7.0, leaves standstill 3 hours;

7) collect supernatant, concentrated, drying and crushing, adds adjuvant, is prepared into granule;

embodiment 3

The preparation of powder of the present invention:

Prescription:

Rhizoma Zingiberis 35 Folium Mori 60 Rhizoma Atractylodis Macrocephalae 60

Fructus Forsythiae 10 Radix Bupleuri 60 Herba Schizonepetae 30

Rhizoma Atractylodis 30 Radix Scutellariae 60 Radix Paeoniae Alba 30

Preparation method:

1) each raw material for standby is taken by above-mentioned weight portion;

2) step 1) pulverizing medicinal materials is crossed 20 mesh sieves, mix homogeneously;

3) by step 2) mixed medicated powder drops in extraction pot, and add the water of medical material weight 8 times amount, adding hydrochloric acid adjust pH is 4.0, soaks 4 hours;

4) first 100 degrees Celsius of steaming and decoctings 1 hour, then temperature control to a 60 DEG C insulation leaches filtrate in 1.5 hours;

5) filtering residue adds initial medical material weight 6 times of water gagings, and adjust pH is 9.0, and water temperature 85 DEG C is extracted and leached filtrate in 60 minutes;

6) combining step 4) and step 5) gained filtrate, adjust pH 7.0, leaves standstill 2 hours;

7) collect supernatant, concentrated, drying and crushing, adds adjuvant, obtained powder.

embodiment 4

The preparation of powder of the present invention:

Prescription:

Rhizoma Zingiberis 40 Folium Mori 40 Rhizoma Atractylodis Macrocephalae 40

Fructus Forsythiae 20 Radix Bupleuri 35 Herba Schizonepetae 20

Rhizoma Atractylodis 20 Radix Scutellariae 40 Radix Paeoniae Alba 20

Preparation method:

1) each raw material for standby is taken by above-mentioned weight portion;

2) step 1) pulverizing medicinal materials is crossed 30 mesh sieves, mix homogeneously;

3) by step 2) mixed medicated powder drops in extraction pot, and add the water of medical material weight 12 times amount, adding hydrochloric acid adjust pH is 4.0, soaks 4 hours;

4) first 100 degrees Celsius of steaming and decoctings 1 hour, then temperature control to a 60 DEG C insulation leaches filtrate in 1.5 hours;

5) filtering residue adds initial medical material weight 6 times of water gagings, and adjust pH is 9.5, and water temperature 85 DEG C is extracted and leached filtrate in 60 minutes;

6) combining step 4) and step 5) gained filtrate, adjust pH 7.0, leaves standstill 2 hours;

7) collect supernatant, concentrated, drying and crushing, adds adjuvant, obtained powder.

embodiment 5 clinical experiment

1 Experimental agents

Powder prepared by the embodiment of the present invention 1;

Two art Radix Bupleuri fall apart (Rhizoma Atractylodis 2 weight portion, Cortex Magnoliae Officinalis 1 weight portion, the Rhizoma Atractylodis Macrocephalae 1 weight portion, Rhizoma Zingiberis 1 weight portion, Cortex Cinnamomi 1 weight portion, Radix Bupleuri 1 weight portion, the Radix Paeoniae Alba 1 weight portion, Radix Gentianae 1 weight portion, Radix Scutellariae 1 weight portion);

2. Clinical Treatment Test

One week age, natural occurrence egg-laying chicken 200 plumage, through epidemiology, clinical symptoms, pathological anatomy, etiological diagnosis, was diagnosed as Salmonella and escherichia coli mixed infection.Morbidity chickling is divided into 2 groups at random: treatment group and matched group, often group is 100 plumages; The powder spice that treatment group gives the embodiment of the present invention 1 preparation by the dosage of every plumage chicken 0.5g every day is fed; Matched group gives the two art Radix Bupleuri spice that falls apart by the dosage of every plumage chicken 2g every day and feeds.Treat 3-5 days all continuously, clinical observation curative effect for two groups.

3. prevention clinical trial

Select 1 age in days clinical health Chinese mugwort pull out increasingly (AA broiler chicken) 2000 plumages, be divided into 4 groups at random: often organize 500 plumages, first group by the dosage of every plumage chicken 0.1g every day give the embodiment of the present invention 1 prepare powder spice feed; Second group gives the two art Radix Bupleuri spice that falls apart by the dosage of every plumage chicken 1g every day and feeds; 3rd group is added chloromycetin by the dosage of 200mg/kg in feedstuff; 4th group is done matched group, in feedstuff, is not added any medicine; Serve on 40 days, clinical observation curative effect.

4. curative effect determinate standard

Cure: after medication 3-5 days, spirit, appetite are good, and diarrhoea stops, and feces is normal, and weightening finish rapidly;

Effective: after medication 3-5 days, spirit, appetite take a turn for the better, and diarrhoea stops, and feces is normal, no longer includes death;

Invalid: after medication 3-5 days, spirit, appetite, symptom of diarrhea etc. have no obvious improvement, the unit interval amount of dying of illness rises or does not have clear improvement.

5. liang a group clinical trial results compares and please refer to table 1.

A table 1 liang group clinical trial results compares

As can be seen from the above table, for salmonellosis and the colibacillosis of chickling, the present invention treats cure rate and total effective rate higher than matched group.Especially cure rate is apparently higher than matched group, has significant difference.The visible consumption of drug composition is in the present invention only the fall apart obvious technical effects of consumption four/obtain for the moment of two art Radix Bupleuri and is better than matched group.It is strong that the medicine prepared by embodiment 1 formula especially of visible Chinese medicine composition of the present invention has synergism for the treatment of chicken diarrhea, the feature that dosage is low, then reduce drug cost to a great extent.

6. liang a group prevention clinical trial compares and refers to table 2

A table 2 liang group prevention clinical trial compares

As can be seen from Table 2, although add first group of Chinese medicine composition of the present invention and add that two art Radix Bupleuri fall apart second group in feedstuff, add the M & M that the 3rd group of chloromycetin all can be suppressed chickling.But, first group when dosage is lower its preventive effect be still significantly better than Chinese medicine matched group second group and western medicine group the 3rd group.Visible Chinese medicine composition of the present invention can nurse one's health animal body function, improves gastrointestinol microorganism group system, strengthens the integrated functions such as premunition, so can prevent salmonellosis and the colibacillosis of chickling preferably.Chinese medicine composition of the present invention can as the salmonellosis of feed additive substitute antibiotics prevention chickling and colibacillosis.

Claims (5)

1. treat a Chinese medicine composition for chicken diarrhea, it is characterized in that, described compositions is prepared from by Rhizoma Zingiberis, Folium Mori, the Rhizoma Atractylodis Macrocephalae, Fructus Forsythiae, Radix Bupleuri, Herba Schizonepetae, Rhizoma Atractylodis, Radix Scutellariae, the Radix Paeoniae Alba.

2. the Chinese medicine composition for the treatment of chicken diarrhea as claimed in claim 1, it is characterized in that, described compositions is prepared from by the medical material of following weight portion:

Rhizoma Zingiberis 30-60 Folium Mori 30-60 Rhizoma Atractylodis Macrocephalae 30-60

Fructus Forsythiae 10-30 Radix Bupleuri 30-60 Herba Schizonepetae 10-30

Rhizoma Atractylodis 10-30 Radix Scutellariae 30-60 Radix Paeoniae Alba 10-30.

3. the Chinese medicine composition for the treatment of chicken diarrhea as claimed in claim 1, it is characterized in that, described compositions is prepared from by the medical material of following weight portion:

Rhizoma Zingiberis 45 Folium Mori 45 Rhizoma Atractylodis Macrocephalae 45

Fructus Forsythiae 20 Radix Bupleuri 40 Herba Schizonepetae 15

Rhizoma Atractylodis 15 Radix Scutellariae 45 Radix Paeoniae Alba 15.

4. the Chinese medicine composition of the treatment chicken diarrhea as described in any one of claim 1-3, is characterized in that, described compositions can be prepared into powder, powder, water preparation.

5. the Chinese medicine composition for the treatment of chicken diarrhea as claimed in claim 1, it is characterized in that, the preparation method of described compositions comprises following steps:

1) each raw material for standby is taken by weight;

2) step 1) pulverizing medicinal materials is crossed 20-40 mesh sieve, mix homogeneously;

3) by step 2) mixed medicated powder drops in extraction pot, and add the water of medical material weight 8-12 times amount, adding hydrochloric acid adjust pH is 2.0-4.0, soaks 4 hours;

4) first steaming and decocting 1-2 hour, then temperature control to a 60 DEG C insulation leaches filtrate in 1.5 hours;

5) filtering residue adds initial medical material weight 4-8 times water gaging, and adjust pH is that 8.0-10.0, water temperature 80-100 DEG C of extraction leaches filtrate in 60 minutes;

6) combining step 4) and step 5) gained filtrate, adjust pH 6.5-7.3, leaves standstill 2-4 hour;

7) supernatant is collected, concentrated, drying and crushing, obtained Chinese medicine composition.