CN105381044A - Traditional Chinese medicine composition for preventing and controlling muscular stomach erosion symptoms of poultry - Google Patents
Traditional Chinese medicine composition for preventing and controlling muscular stomach erosion symptoms of poultry Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for preventing and controlling muscular stomach erosion symptoms of poultry. According to the characteristic that the muscular stomach erosion symptoms of the poultry appear in the stomach and intestine but the root cause of the muscular stomach erosion is dysfunction of the spleen in transportation and the fundamental principles of 'symptomatic treatment in acute condition and radical treatment in chronic condition', the formula of the traditional Chinese medicine composition uses folium isatidis for clearing away heat and toxic materials and Chinese barberry roots for eliminating dampness and clearing fire as monarch drugs, uses rhizoma atractylodis for drying damp, strengthening spleen, expelling wind and removing cold as adjuvant drugs, uses poria cocos for clearing damp, promoting diuresis, tonifying the spleen and quieting the heart and dried orange peels for regulating qi-flowing for strengthening the spleen as supplementary drugs, uses licorice for tonifying the spleen and qi to moderate the properties of the medicines, adapts to the symptoms of the muscular stomach erosion in groups at different paroxysm stages and achieves the purposes of treating both symptoms and root causes. Clinical applications of a large number of poultry diseases show that the traditional Chinese medicine composition has the advantages of being definite in effect, free of toxic and side effects and medicine residues and the like.
Description
Technical field
The invention belongs to veterinary drug preparation to produce and application, relate to a kind of Chinese prescription, especially relate to a kind of Chinese medicine composition preventing and treating poultry gizzard erosion.
Background technology
In recent years, popular a kind of disease that is principal character with proventriculitis, gizzard erosion gradually in China's major part commercial meat bird cultivation compact district.Morbidity chicken group growth retardation, chicken body weight are uneven, and feed intake is low, become thin, exhaustion is dead, cut open that inspection symptom main manifestations is muscular stomach cutin membrane ulcer, crackle, necrosis, to come off, usually with glandular stomach swelling, intestinal Catarrhal or hemorrhagic inflammation.The cause of disease of this disease is complicated, all has relation with ambient humidity, feed mould, virus, antibacterial etc.Due to the complexity of the cause of disease, general antibacterial, antiviral treatment are difficult to receive effective, and between death rate 10-50%, other the infected of secondary is even complete, and group eliminates.
Chinese veterinarian is theoretical dialectically to be thought to this, the general performance that this disease belongs to dysfunction of the spleen in transportation, taste are become estranged, but different from pure proventriculitis.Poultry internal organs are tender and lovely, and hedge loosens, and yin and yang 2 Qi is all more childish and tender; Lung, spleen, the dirty deficiency of kidney three, defend outer function weak, poor to the resistance of exopathogen.Spleen is lunar wet soil, state placed in the middle and main transporting, and with stomach with by water paddy, defeated cloth is precise and tiny.Its property is liked dry evil and is wet, and hen house is damp and hot, and dysfunction of the spleen in transportation very easily appears in poultry, taste are become estranged.Damp is stranded in middle Jiao, dysfunction of the spleen, and mechanism of qi is obstructed, and damp perfusion the intestines and stomach, heat-transformation for a long time, causes glandular stomach, muscular stomach, intestinal ulcer, inflammation.At the beginning of morbidity, chicken group, there is a large amount of dyspeptic loose stool, should take now spleen reinforcing as the rule for the treatment of; Fall ill more anxious, main manifestations is that feed intake declines, glandular stomach swelling, and muscular stomach mucosa blackout or brown stain, should based on nourishing the stomach; Fall ill serious, main manifestations is fragmentary dead for occurring, muscular stomach mucosa breach, ulcer, comes off, and now exopathogen enters interior heat-transformation, must be the rule for the treatment of with heat-clearing and toxic substances removing.
Control at present to proventriculitis, gizzard erosion, although report, some are antibacterial, antiviral comprehensive therapeutic plan, also the on probation of some Chinese traditional patent formulations is had, but still there are the following problems: 1. due to the complexity of this cause of disease, antibacterial, antiviral therapy is often difficult to obtain effective, and adds the risk of poultry product food safety.2. reported Chinese prescription, or the medicine of Chinese medicine and western medicine coupling are only the apparent symptom prescriptions for proventriculitis, gizzard erosion, the principles of formulating prescriptions are not considered nourishing the stomach must the base therapy principle of first spleen invigorating, are thus difficult to radical cure.3. reported Chinese prescription, often according to one of above-mentioned each Therapeutic Principle, is difficult to take into account Different Individual in chicken group and is in the feature in different onset stage.Although some has indicated the plus-minus principle of basic prescription in use, in fact, under large-scale cultivation condition, picking out for the individuality of (often 1-2 ten thousand) various different syndromes in a colony and treat respectively, has been at all infeasible.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to, by prescription again after studying Chinese medicine pharmacology, provide a kind of Chinese medicine composition preventing and treating poultry gizzard erosion.Said composition is as a kind of pure Chinese medicinal preparation, and to effectively preventing and treating poultry gizzard erosion, and the use, minimizing drug residue etc. that reduce antibacterials in poultry farming process are significant.
In order to solve the problem existing for background technology, the present invention is by the following technical solutions:
For preventing and treating a Chinese medicine composition for poultry gizzard erosion, formed by the active fraction preparation of following weight portion: Folium Isatidis 30-60 part, Radix Berberidis 20-40 part, Rhizoma Atractylodis 30-50 part, Poria 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Radix Glycyrrhizae 10-25 part.
Preferably, the described Chinese medicine composition for preventing and treating poultry syndrome of pathogen invading lung-defense phase, is formed by the active fraction preparation of following weight portion: Folium Isatidis 40-50 part, Radix Berberidis 20-30 part, Rhizoma Atractylodis 30-45 part, Poria 15-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Glycyrrhizae 10-20 part.
Further preferably, the described Chinese medicine composition for preventing and treating poultry syndrome of pathogen invading lung-defense phase, is formed by the active fraction preparation of following weight portion: Folium Isatidis 40-50 part, Radix Berberidis 25-30 part, Rhizoma Atractylodis 30-40 part, Poria 20-25 part, Pericarpium Citri Reticulatae 20-25 part, Radix Glycyrrhizae 15-20 part.
The present invention presses the Chinese powder medicine of the general production technology manufacture of veterinary drug powder, fed by spice or boiled water punching is stewing, decoct after feed for poultry, in case fowl gizzard erosion of managing a household.
The present invention becomes oral liquid by the general production technology manufacture of veterinary drug oral liquid, also can according to the granule of veterinary drug granule technological process of production manufacture.
Therefore, the described Chinese medicine composition for preventing and treating poultry gizzard erosion, it is powder, granule or oral liquid.Described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
According to Chinese medicine Historical Data Data About, above-mentioned 5 taste Chinese crude drugs have following pharmacologically active and function cures mainly:
Folium Isatidis: the dried leaves of cruciferae isatis IsatisindigoticaFort..Property bitter, cold, GUIXIN, stomach warp.Function heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, sends out speckle dermexanthesis, the diseases such as hematodiarrhoea.
Radix Berberidis: for Berberidaceae plant stings root bark or the peel of stem of black pearl, berberis brachypoda Maxim, black stone pearl etc.Bitter in the mouth, cold in nature, return liver, stomach, large intestine channel.Function heat clearing away; Dampness; Eliminating fire and detoxication.Main dysentery due to damp-heat; Diarrhoea.
Rhizoma Atractylodis: the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodeslancea (Thunb.) DC. or Atractylis chinensis Atractylodeschinensis (DC.) Koidz. is used as medicine.Property pungent, bitter, temperature, return spleen, stomach, Liver Channel.Function is drying damp and strengthening spleen, expelling wind and cold, cures mainly the diseases such as the spleen and stomach being stranded by dampness, inappetence, damp invasion of lower energizer.
Poria: be used as medicine with the dry sclerotia of On Polyporaceae Poria Poriacocos (Schw.) Wolf.Property sweet, light, flat, GUIXIN, lung, spleen, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For insufficiency of the spleen lack of appetite, the disease such as to have loose bowels in loose stool.
Pericarpium Citri Reticulatae: there is regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.Select the dry mature skin for rutaceae orange and variety thereof.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select as dicotyledon pulse family Leguminosae Radix Glycyrrhizae GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. G.inflataBat., or the root and rhizome of Glycyrrhiza glabra L. G.glabraL..
Compared with prior art, what the present invention relates to has the following advantages and marked improvement for the Chinese medicine composition tool preventing and treating poultry gizzard erosion: 1. according to the dialectical relationship that The spleen and the stomach are interior-exteriorly related, for poultry gizzard erosion symptom at gastrointestinal root in the feature of dysfunction of the spleen in transportation, and the basic principle of " symptomatic treatment in acute condition; relieving the primary symptom in a chronic case ", be the basic rule for the treatment of with heat-clearing and toxic substances removing, be aided with strengthening the spleen and nourishing the stomach, by spleen invigorating QI invigorating, realize the target for the treatment of both the principal and secondary aspects of a disease.2. this prescription lets out the Radix Berberidis of fire altogether for monarch drug with the Folium Isatidis of heat-clearing and toxic substances removing and dampness, with the Rhizoma Atractylodis of drying damp and strengthening spleen, expelling wind and cold for minister, assistant is with the Poria of promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming and the Pericarpium Citri Reticulatae with regulating qi-flowing for strengthening spleen, with the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription of invigorating the spleen and replenishing QI, be adapted to the disease in gizzard erosion different onset stage in colony: heat-clearing and toxic substances removing is to take stopgap measures, regulating qi-flowing for strengthening spleen is with nourishing the stomach, and expelling wind and cold is with spleen invigorating.3. the present invention is pure Chinese medicinal preparation, and be prepared from by 6 taste Chinese crude drugs, raw material is simple and easy to get, and cost is lower, economic and practical, effectively reduces antibiotic use in poultry farming process, and it is significant to reduce drug residue.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment one: the preparation of Chinese powder medicine
Chinese medicine composition by Folium Isatidis 45 parts, Radix Berberidis 25 parts, Rhizoma Atractylodis 30 parts, 25 parts, Poria, Pericarpium Citri Reticulatae 25 parts, 15 parts, Radix Glycyrrhizae composition.Described each taste Chinese medicine is the prepared slices of Chinese crude drugs meeting " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.By each Chinese medicine co-grinding, cross 60 order spin vibration sieves, thicker Chinese medicinal granule is again pulverized, is sieved, and always mixed traditional Chinese medicine fine powder, is packed as 1kg/ bag, obtains final product.By the Chinese powder medicine that this method is produced, the mode of generally being fed by spice for the prevention of the poultry gizzard erosions such as broiler, laying hen, duck, when being used for the treatment of, can also by stewing 30 minutes of this powder 8-10 times amount boiled water punching, supernatant is drunk water, and medicinal residues spice, has onset feature rapidly.
Embodiment two: the preparation of Chinese medicine oral liquid
Chinese medicine composition by Folium Isatidis 40 parts, Radix Berberidis 25 parts, Rhizoma Atractylodis 30 parts, 25 parts, Poria, Pericarpium Citri Reticulatae 20 parts, 20 parts, Radix Glycyrrhizae composition.Described each taste Chinese medicine is the prepared slices of Chinese crude drugs meeting " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Each Chinese medicine is dropped into extraction pot, add 10 times amount (weight ratio) purified water and soak 5 hours, be heated to boiling, be incubated 1 hour, wait and coldly leach supernatant, add 8 times amount (weight ratio) purified water again and be heated to boiling, be incubated 1 hour, filter, merge twice filtrate, being evaporated to crude drug than being 0.5kg/L, adding ethanol to 75% (volume ratio), precipitating 12 hours, supernatant heating recovery ethanol, and medicinal liquid is evaporated to crude drug than for 1kg/L, it is anticorrosion to add 0.3% sodium benzoate, fill, gland and get final product.By the Chinese medicine oral liquid that this method is produced, by drinking-water application after can directly diluting.Because Chinese medicine is through extraction process, have easy to use, onset is feature rapidly.
Embodiment three: the preparation of Chinese medicine granules
Chinese medicine composition by Folium Isatidis 46 parts, Radix Berberidis 28 parts, Rhizoma Atractylodis 35 parts, 22 parts, Poria, Pericarpium Citri Reticulatae 20 parts, 18 parts, Radix Glycyrrhizae composition.Described each taste Chinese medicine is the prepared slices of Chinese crude drugs meeting " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Each Chinese medicine is dropped into extraction pot, add 10 times amount (weight ratio) purified water and soak 5 hours, be heated to boiling, be incubated 1 hour, wait and coldly leach supernatant, add 8 times amount (weight ratio) purified water again and be heated to boiling, be incubated 1 hour, filter, merge twice filtrate, be evaporated to crude drug than being 0.5kg/L, add ethanol to 75% (volume ratio), precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is evaporated to crude drug than being 5kg/L, add suitable amount of sucrose or glucose, granulate, dry, make the granule that crude drug content is 1kg/kg, subpackage and get final product.By Chinese medicine granules prepared by this method, warm water can melt during application, fed by drinking-water, there is onset rapid, the features such as accumulating is convenient.
Embodiment four: traditional Chinese medicine composition for treating chicken heresy of the present invention violates the clinical practice example that lung defends card
For verifying the clinical efficacy of Chinese prescription of the present invention, selecting veterinary drug market to have the amoxicillin of good result and cimetidine (cimetidine) as positive control medicine, having carried out contrast test.In view of poultry gizzard erosion is difficult to the animal model being set up poultry by the mode of artificial challenge, and on veterinary clinic, such disease is multiple, so select to possess contrast test condition, the affected animal of plant of natural occurrence tests.
1. materials and methods
1.1 test material
Chinese powder medicine, by method preparation described in embodiment 1; Chinese medicine oral liquid, by method preparation described in embodiment 2; Chinese medicine granules, by method preparation described in embodiment 3.
Positive control medicine: amoxicillin, cimetidine soluble powder, by plant purchased from Lukang Medical Co., Ltd., Shandong.
Experimental animal is the commercial meat bird of natural occurrence, meets gizzard erosion disease through cuing open inspection diagnosis.
1.2 test method
Luo Si 308 commercial generation white meat-type chickens 24634 plumage of 9 age in days natural infection morbidities, being diagnosed as gizzard erosion through cuing open inspection, being divided into 4 groups at random.Wherein, positive controls two hen houses, totally 9867 plumages, cimetidine soluble powder, amoxicillin by specification drinking water administration, every day 1 time, being used in conjunction 5 days is a course for the treatment of.
Chinese powder medicine group 1 hen house 4906 plumage, calculates dosage by 1.5g/kg body weight.Chinese medicine is directly admixed feedstuff and is fed, every day 1 time, and being used in conjunction 5 days is a course for the treatment of.
Chinese medicine oral liquid group and each 1 hen house of Chinese medicine granules group, amount of livestock on hand is respectively 4963 plumages and 4898 plumages, with crude drug cubage, calculates dosage by 1.5g/kg body weight.Every day 1 time, being used in conjunction 5 days is a course for the treatment of.
2. result of the test
2.1 morbidity chicken public sentiment condition and diagnosis
The 9 age in days Luo Si 308 commercial generation white meat-type chickens that therapeutic test is raised with Pingdu Animal Raising Zone, animal system Shandong.This Animal Raising Zone has 6 hen houses, every hen house livestock on hand broiler about 15000 plumage.Raise after carrying out Newcastle disease attenuated Seedling immunity to 6 ages in days, wherein 5 hen houses occur that increasing is expected slowly or material reducing, sporadicly death successively, the incidence that thin and weak chicken is increased.Employing astragalus polysaccharides, ciprofloxacin prevent and treat 2 days, fail effectively to improve advancing of disease.Suddenly about 2% is increased to death during 9 age in days.The chicken that dies of illness cuts open the swelling of inspection visible glandular stomach height, outward appearance is creamy white, and severe patient is aubergine; Glandular stomach nipple mucosa edema, serious erosion or ulcer; Muscular stomach atrophy, without food or there is a small amount of food, is separated with muscle layer; Digestive tract has petechia in various degree, pancreas, gallbladder enlargement.The incidence of chicken group and cut open the performance that inspection symptom meets gizzard erosion disease.
2.2 contrast test
This type of disease is also multiple habitually in the past in this plant, and adopt broad spectrum antibiotic in conjunction with cimetidine antiviral Comprehensive Treatment traditionally, can control dead continuing to increase to a certain extent, but the course for the treatment of is longer, later stage death rate remains high.Through consulting with plant technical staff, curative effect contrast test is carried out to 5 hen houses of morbidity.Wherein, 2 hen houses adopt cimetidine to coordinate amoxicillin, as positive controls; Other 3 hen houses, Stochastic choice uses Chinese powder medicine, Chinese medicine granules and Chinese medicine oral liquid as experimental group respectively.The mortality rate that matched group and each experimental group were all added up in the course for the treatment of (5 days) is as shown in table 1.
Table 1 herbal mixture and antibacterial therapy result (5 days statistical datas)
* each experimental group sample number system enters young number by each hen house, deducts accumulative dead number of washing in a pan and calculates and obtain
After two positive controls adopt antibacterial, antiviral therapy, mortality rate declines to some extent, until medication the 5th day, each hen house still has 8-10 death only.Chinese powder medicine experimental group, after the 4th day, not there is not death in medication, Chinese medicine oral liquid, the medication of Chinese medicine granules experimental group did not occur death after the 3rd day substantially more substantially.Show, Chinese drug-treated group of the present invention effectively can control advancing of disease, and Chinese medicine is after extracting, and onset is very fast.
The requirement of Hou Ying plant, two positive controls also adopt Chinese powder medicine to treat, and are used in conjunction 3 days and effectively control death afterwards.When after this raising to 35 age in days, the Chinese powder medicine spice prevention of plant's 6 hen houses, dosage reduces by half, and is used in conjunction 5 days, delivers for sale and does not occur similar conditions, demonstrate the effect of this Chinese medicine further to 45 days.
Claims (5)
1. for preventing and treating a Chinese medicine composition for poultry gizzard erosion, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Folium Isatidis 30-60 part, Radix Berberidis 20-40 part, Rhizoma Atractylodis 30-50 part, Poria 15-30 part, Pericarpium Citri Reticulatae 15-30 part, Radix Glycyrrhizae 10-25 part.
2. the Chinese medicine composition for preventing and treating poultry gizzard erosion according to claim 1, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Folium Isatidis 40-50 part, Radix Berberidis 20-30 part, Rhizoma Atractylodis 30-45 part, Poria 15-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Glycyrrhizae 10-20 part.
3. the Chinese medicine composition for preventing and treating poultry gizzard erosion according to claim 2, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Folium Isatidis 40-50 part, Radix Berberidis 25-30 part, Rhizoma Atractylodis 30-40 part, Poria 20-25 part, Pericarpium Citri Reticulatae 20-25 part, Radix Glycyrrhizae 15-20 part.
4. the Chinese medicine composition for preventing and treating poultry gizzard erosion according to any one of claim 1-3, is characterized in that: this Chinese medicine composition is powder, granule or oral liquid.
5. the Chinese medicine composition for preventing and treating poultry gizzard erosion according to any one of claim 1-3, is characterized in that: described poultry is chicken, duck, goose or Carnis Coturnicis japonicae.
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| CN201510975445.6A CN105381044A (en) | 2015-12-23 | 2015-12-23 | Traditional Chinese medicine composition for preventing and controlling muscular stomach erosion symptoms of poultry |
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| CN201510975445.6A CN105381044A (en) | 2015-12-23 | 2015-12-23 | Traditional Chinese medicine composition for preventing and controlling muscular stomach erosion symptoms of poultry |
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| CN105381044A true CN105381044A (en) | 2016-03-09 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421036A (en) * | 2016-08-31 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicinal composition for treating chicken gizzard erosion |
| CN110755492A (en) * | 2019-10-23 | 2020-02-07 | 潍坊市华程生物科技有限公司 | Medicinal plant essential oil composition for preventing and treating poultry gastrointestinal damp-heat disease |
-
2015
- 2015-12-23 CN CN201510975445.6A patent/CN105381044A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421036A (en) * | 2016-08-31 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicinal composition for treating chicken gizzard erosion |
| CN110755492A (en) * | 2019-10-23 | 2020-02-07 | 潍坊市华程生物科技有限公司 | Medicinal plant essential oil composition for preventing and treating poultry gastrointestinal damp-heat disease |
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