CN106344876A - Traditional Chinese medicine composition for controlling livestock/poultry respiratory diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition for controlling livestock/poultry respiratory diseases and preparation method thereof Download PDFInfo
- Publication number
- CN106344876A CN106344876A CN201610912761.3A CN201610912761A CN106344876A CN 106344876 A CN106344876 A CN 106344876A CN 201610912761 A CN201610912761 A CN 201610912761A CN 106344876 A CN106344876 A CN 106344876A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- chinese medicine
- radix
- citri tangerinae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 54
- 239000000203 mixture Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 208000023504 respiratory system disease Diseases 0.000 title claims abstract description 11
- 244000144972 livestock Species 0.000 title claims abstract description 6
- 244000144977 poultry Species 0.000 title abstract description 9
- 241000255791 Bombyx Species 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 11
- 239000006071 cream Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000002386 leaching Methods 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- -1 oral solutionses Substances 0.000 claims description 4
- 241000219061 Rheum Species 0.000 claims description 3
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000011805 ball Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000006196 drop Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 26
- 201000010099 disease Diseases 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 22
- 206010011224 Cough Diseases 0.000 abstract description 19
- 230000001717 pathogenic effect Effects 0.000 abstract description 16
- 208000006673 asthma Diseases 0.000 abstract description 9
- 244000052769 pathogen Species 0.000 abstract description 8
- 208000011580 syndromic disease Diseases 0.000 abstract description 7
- 208000000059 Dyspnea Diseases 0.000 abstract description 3
- 206010013975 Dyspnoeas Diseases 0.000 abstract description 3
- 206010061428 decreased appetite Diseases 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 241000255789 Bombyx mori Species 0.000 abstract 1
- 241000931705 Cicada Species 0.000 abstract 1
- 235000003392 Curcuma domestica Nutrition 0.000 abstract 1
- 244000008991 Curcuma longa Species 0.000 abstract 1
- 241000935235 Fritillaria meleagris Species 0.000 abstract 1
- 241001673966 Magnolia officinalis Species 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 235000003373 curcuma longa Nutrition 0.000 abstract 1
- 235000013976 turmeric Nutrition 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 description 28
- 239000008280 blood Substances 0.000 description 23
- 210000004369 blood Anatomy 0.000 description 23
- 206010062717 Increased upper airway secretion Diseases 0.000 description 21
- 208000026435 phlegm Diseases 0.000 description 21
- 210000000214 mouth Anatomy 0.000 description 16
- 241000287828 Gallus gallus Species 0.000 description 14
- 208000002193 Pain Diseases 0.000 description 12
- 206010007247 Carbuncle Diseases 0.000 description 9
- 102100038353 Gremlin-2 Human genes 0.000 description 8
- 101001032861 Homo sapiens Gremlin-2 Proteins 0.000 description 8
- 239000003172 expectorant agent Substances 0.000 description 8
- 230000003419 expectorant effect Effects 0.000 description 8
- 231100000614 poison Toxicity 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 208000015181 infectious disease Diseases 0.000 description 7
- 210000001015 abdomen Anatomy 0.000 description 6
- 241000411851 herbal medicine Species 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 206010010904 Convulsion Diseases 0.000 description 5
- 201000006549 dyspepsia Diseases 0.000 description 5
- 239000002574 poison Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 206010023126 Jaundice Diseases 0.000 description 4
- 206010068319 Oropharyngeal pain Diseases 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 230000001174 ascending effect Effects 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 230000036461 convulsion Effects 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000002398 materia medica Substances 0.000 description 4
- 238000010926 purge Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 206010000077 Abdominal mass Diseases 0.000 description 3
- 241000271566 Aves Species 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 3
- 239000004375 Dextrin Substances 0.000 description 3
- 206010017553 Furuncle Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 235000019425 dextrin Nutrition 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 208000001780 epistaxis Diseases 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 235000021266 loss of appetite Nutrition 0.000 description 3
- 201000007227 lymph node tuberculosis Diseases 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 231100000862 numbness Toxicity 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 206010037844 rash Diseases 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000013599 spices Nutrition 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- BITDLWAQPKSXTF-UHFFFAOYSA-M 1-[(3-nitrophenyl)methoxymethyl]pyridin-1-ium;chloride Chemical compound [Cl-].[O-][N+](=O)C1=CC=CC(COC[N+]=2C=CC=CC=2)=C1 BITDLWAQPKSXTF-UHFFFAOYSA-M 0.000 description 2
- APTNOIWSCDBIAS-UHFFFAOYSA-N 5,10,11-trihydroxy-9,9-bis(hydroxymethyl)-2,2,6a,6b,12a-pentamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid Chemical compound C1C(O)C(O)C(CO)(CO)C2CCC3(C)C4(C)CC(O)C5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C APTNOIWSCDBIAS-UHFFFAOYSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010012218 Delirium Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010013954 Dysphoria Diseases 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- 206010033425 Pain in extremity Diseases 0.000 description 2
- 206010034107 Pasteurella infections Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 208000033809 Suppuration Diseases 0.000 description 2
- 206010043376 Tetanus Diseases 0.000 description 2
- IUKLSMSEHKDIIP-BZMYINFQSA-N Verticine Chemical compound C([C@@H]1[C@@H](O)C[C@H]2[C@@H]3CC[C@@H]4[C@]5(C)O)[C@@H](O)CC[C@]1(C)[C@H]2C[C@H]3[C@@H]4CN1[C@H]5CC[C@H](C)C1 IUKLSMSEHKDIIP-BZMYINFQSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000000954 anitussive effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 201000007201 aphasia Diseases 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000004320 controlled atmosphere Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 229960003722 doxycycline Drugs 0.000 description 2
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 201000003453 lung abscess Diseases 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 230000000116 mitigating effect Effects 0.000 description 2
- 229960002581 moroxydine hydrochloride Drugs 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 201000005115 pasteurellosis Diseases 0.000 description 2
- IUKLSMSEHKDIIP-UHFFFAOYSA-N petine Natural products CC1(O)C2CCC3C4CC(O)C5CC(O)CCC5(C)C4CC3C2CN2C1CCC(C)C2 IUKLSMSEHKDIIP-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- VQMZQKBLIKANMK-IKFJEIPGSA-N (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1R,2S,4S,5'S,6R,7S,8R,9S,12S,13S,16S,18R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol (2S,3R,4S,5S,6R)-2-[(2R,3S,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1S,2R,4R,5'S,6R,7R,8S,9S,12R,13S,16R,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound C[C@H]1CC[C@@]2([C@@H]([C@@H]3[C@H](O2)C[C@H]4[C@@]3(CC[C@@H]5[C@@H]4CC[C@@H]6[C@@]5(CC[C@H](C6)O[C@H]7[C@H]([C@H]([C@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)OC1.C[C@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC[C@H]6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C)OC1 VQMZQKBLIKANMK-IKFJEIPGSA-N 0.000 description 1
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010002953 Aphonia Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 240000004528 Catalpa ovata Species 0.000 description 1
- 235000010005 Catalpa ovata Nutrition 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 241000208365 Celastraceae Species 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- 206010011469 Crying Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 241000711450 Infectious bronchitis virus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000001705 Mouth breathing Diseases 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 241000606856 Pasteurella multocida Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- QMQIQBOGXYYATH-IDABPMKMSA-N Ruscogenin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)[C@H](O)C[C@H](O)CC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 QMQIQBOGXYYATH-IDABPMKMSA-N 0.000 description 1
- BSUPFYRQXCQGLJ-UHFFFAOYSA-N Ruscogenin Natural products CC1CCC2(OC1)OC3C(O)C4C5CC=C6CC(O)CC(O)C6(C)C5CCC4(C)C3C2C BSUPFYRQXCQGLJ-UHFFFAOYSA-N 0.000 description 1
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 235000000336 Solanum dulcamara Nutrition 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010044684 Trismus Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- KGGGRGBDMBZXKF-UHFFFAOYSA-N Virganreagenin G Natural products C1C(O)C(O)C(C)(CO)C2CCC3(C)C4(C)CC(O)C5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C KGGGRGBDMBZXKF-UHFFFAOYSA-N 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000008645 cold stress Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000009402 cross-breeding Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- ZICQBHNGXDOVJF-UHFFFAOYSA-N diamantane Chemical compound C1C2C3CC(C4)CC2C2C4C3CC1C2 ZICQBHNGXDOVJF-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- QMQIQBOGXYYATH-UHFFFAOYSA-N epiruscogenin Natural products CC1C(C2(CCC3C4(C)C(O)CC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 QMQIQBOGXYYATH-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000008642 heat stress Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- MGCQZNBCJBRZDT-UHFFFAOYSA-N midodrine hydrochloride Chemical compound [H+].[Cl-].COC1=CC=C(OC)C(C(O)CNC(=O)CN)=C1 MGCQZNBCJBRZDT-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 235000002378 plant sterols Nutrition 0.000 description 1
- 229930189407 platycodin Natural products 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 229940109990 ruscogenin Drugs 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 201000002327 urinary tract obstruction Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for controlling livestock/poultry respiratory diseases and a preparation method thereof. Specifically, a veterinary patent medicine prepared from the raw materials including rhizoma anemarrhenae, thunberg fritillary bulb, platycodon grandiflorum, magnolia officinalis, orange peel, stiff silkworm, cicada slough, turmeric, rheum officinale and the like is adopted for treating or relieving lung-heat cough and asthma caused by pathogen or external environment. The traditional Chinese medicine composition is applied to diseases featuring cough, dyspnea, anorexia, growth speed droop, reduction of feed utilization rate and the like caused by the porcine respiratory disease syndrome. Through years of research, the medicine provided by the invention realizes an obvious clinical treatment effect and has the characteristics of good treatment effect, high cure rate, no side effects and the like.
Description
Technical field
The present invention relates to poultry field of medicaments, particularly to a kind of Chinese medicine composition of preventing and treating livestock and birds respiratory disease and its
Preparation method.
Background technology
In the centralization-breeding factory in the many areas of China, poultry stress environment (as cold stress, heat stress etc.) in certain
Under stimulation, the pathogenic microorganism such as infection virus, antibacterial, parasite, a series of syndromes showing in poultry respiratory system
Group.Porcine respiratory disease complex (prdc) is one of most important disease in Chinese pig industry at present, and pig farm is because this disease is normal
Lead to serious economic loss.Porcine respiratory disease syndrome all can occur throughout the year, in autumn Mo, winter and spring sickness rate
Highest, generally in 30-70%, case fatality rate, in 10-30%, takes place mostly in child care later stage and growing and fattening phase, sickness rate 30-
60%.Primary disease can lead to animal heat to raise, and feed intake declines, and the speed of growth is slow, leads to the economy such as marketing time prolongation to be asked
Topic, can lead to animal dead when treating not in time.
Stress can significantly reduce the resistance of pig, promotes the generation of infection.On the pig farm that prdc occurs, due to cause of disease
Complexity, factor of transmission is numerous, and the effect of Drug therapy is often not very well.During the application such disease of antibiotic therapy, due to sending out
Cause of disease is very big because of its Different therapeutical effect different.And certain antibiotic of single application affects it is easy to produce Resistant strain for a long time
Curative effect；When antibacterial and mycoplasma are with virus mixed infection, the curative effect of antibiotic is unsatisfactory.In immunity inoculation prevention, clinical
Research finds, the protective effect of inactivated vaccine is very limited.Inoculation Attenuate vaccine has certain risk again, and immunity inoculation then can shadow
Sound immune response, sometimes generation antibody horizontal are relatively low.
Infectious bronchitis of chicken is a kind of acute high degree in contact breathing being caused by avian infectious bronchitis viruses
Road transmission disease.It is characterized in that dyspnea, send sound, cough, mouth breathing, sneeze.Primary disease infected chicken, no obvious product
Species diversity.The chicken of various ages in days is all susceptible, but the chicken symptom in 5 week old is more apparent, and mortality rate can be to 15～19%.Morbidity season
It is more common in Qiu Mozhi spring Mo next year, but the most serious with winter, it is one of principal disease of harm poultry husbandry.The pathogen of primary disease
Belong to coronaviridae coronavirus genuses, have certain resistance to low temperature, there is very strong variability, divide in the world at present
Separate out more than 30 serotype.This disease almost spreads over all poultry country of the world, is widely distributed.At present, treat this disease the most normal
It is Chinese medicine and antiviral Western medicine, because its prescription is unreasonable or simply simple pulverizing, particle diameter is excessive, drug release for Chinese medicine
Relatively slow, lead to its bioavailability relatively low, clinical effectiveness is not fine；And various antiviral drugs such as ribavirin, diamantane (obsolete)
The An Deng Ministry of Agriculture has prohibitted the use of.
Content of the invention
The present invention is in order to make up the deficiencies in the prior art, there is provided a kind of effective percentage is high, the preventing and treating poultry of stable curative effect exhale
Inhale Chinese medicine composition of tract disease and preparation method thereof.
The present invention is achieved through the following technical solutions:
A kind of preventing and treating livestock and birds respiratory disease Chinese medicine composition it is characterised in that by following weight proportion crude drug prepare and
Become: Rhizoma Anemarrhenae 15-30 part, Bulbus Fritillariae Thunbergii 15-30 part, Radix Platycodoniss 15-30 part, Cortex Magnoliae Officinalis 15-30 part, Pericarpium Citri tangerinae 15-30 part, 5 ~ 25 parts of Bombyx Batryticatus,
5 ~ 20 parts of Periostracum Cicadae, 10 ~ 30 parts of Rhizoma Curcumae Longae, 5 ~ 20 parts of Radix Et Rhizoma Rhei.
Further, be prepared from by the crude drug of following weight proportion: 20 parts of the Rhizoma Anemarrhenae, 20 parts of Bulbus Fritillariae Thunbergii, 20 parts of Radix Platycodoniss,
20 parts of Cortex Magnoliae Officinalis, 20 parts of Pericarpium Citri tangerinae, 15 parts of Bombyx Batryticatus, 12 parts of Periostracum Cicadae, 20 parts of Rhizoma Curcumae Longae, 12 parts of Radix Et Rhizoma Rhei.
Further, described compositionss are it is characterised in that described dosage form is selected from: tablet, capsule, granule, ball
Agent, powder, unguentum, oral solutionses, injection, suppository, spray, drop, patch.
Present invention also offers the preparation method of described compositionss is it is characterised in that step is as follows: take the Rhizoma Anemarrhenae, Bulbus Fritillariae Thunbergii
Mother, Radix Platycodoniss, Cortex Magnoliae Officinalis, Pericarpium Citri tangerinae, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, rhubarb medicinal material add 8-12 times amount decocting boil or 40%-70% alcohol reflux
Extract 2-3 time, each 1-2 hour, united extraction liquid, filter, stand overnight, leaching supernatant, be evaporated to relative density
1.16～1.24 (50 DEG C), it is dried to dry cream, dry cream pulverized 100 mesh sieves, add appropriate amount of auxiliary materials, make compositionss.
The Chinese medicine composition of the present invention, its side solution is as follows:
This cause of disease cold-evil invades, strongly fragrant longization heat, and heat is amassed and causes lung qi not smooth in lung, causes lung meridian excess-heat and send out；Diseases caused by exogenous pathogenic factor epidemic disease, phase
Mutually infect.In side, the pungent flat gas of Bombyx Batryticatus is light and floating and yang invigorating, dispelling pathogenic wind and eliminating phlegm, detoxicating and resolving stagnation of pathogens, and the performance of its Qinghua yang invigorating is drawn on clearing heat in QI system
Towards in mouth；Periostracum Cicadae dispelling wind and heat pathogens, expelling pathogenic factors from the exterior is gone out；Radix Platycodoniss toil is trembled with fear, opening lung-energy, preventing phlegm from forming and stopping coughing, carries medicine up.Rhizoma Curcumae Longae circulation of qi promoting dissipates
Strongly fragrant, removing blood stasis stimulate the menstrual flow, can dispersing swelling and dissipating binds, ward off epidemic disease and cut down evil；Cortex Magnoliae Officinalis circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma；Radix Et Rhizoma Rhei bitter in the mouth is cold in nature,
Abnormal smells from the patient is all thick, heavy and drop, clearing away heat-fire, and it is descending to draw heat, and can cool the blood dissipate blood stasis, attack stagnant, clearing away damp-heat, removing toxicity for eliminating carbuncles.The Rhizoma Anemarrhenae
Bitter in the mouth is trembled with fear, clearing away heat-fire, nourshing Yin and drynsessmoistening prescription；Bulbus Fritillariae Thunbergii bitter sweet is slightly cold, moistening the lung and resolving phlegm, and two medicine phases must be use, removing heat from the lung and dissipating phlegm cough-relieving.Entirely
Fang Xianghe, the sun clearly in Bombyx Batryticatus, Periostracum Cicadae, Radix Platycodoniss yang invigorating；Turbid yin in Rhizoma Curcumae Longae, Cortex Magnoliae Officinalis, Radix Et Rhizoma Rhei fall the moon, one rise and one drop, Pericarpium Citri tangerinae is managed
In controlled atmosphere, drying dampness to eliminate phlegm, make inside and outside leading to with the duty of multiple lifting, and the pernicious influence of miscellaneous QI disappears.All medicines share collection a surname, clear, under,
With in a side, using medicines of both cold and hot natures simultaneously, mutual causality of ascending and descending, logical three Jiao of a surname, bar reaches QI and blood, makes whole body QI and blood smooth；Both sending up the lucid YANG and the turbid descending were evil,
Both lung qi dispersing gas and scattered stagnated fire, removes pathogenic heat purging FU-organs gas, solution evil poison promoting blood circulation network, leads hot and suffocating, harmonizing the functional activities of vital QI off, so that pathogenic heat is passed through inside descending
Road, pathological product (turbid damp, expectorant, the stasis of blood) has the outer machine reaching internal diabetes, plays ascending the clear and descending the turbid altogether, clear purte the white, lung qi dispersing eliminating the phlegm, sending down the abnormal ascending QI are put down
The work(breathed heavily.
In side, the effect of each taste medicine is as follows:
The Rhizoma Anemarrhenae: bitter in the mouth, cold in nature.Return lung, stomach, kidney channel.Effect clearing away heat-fire, nourshing Yin and drynsessmoistening prescription.Cure mainly pyreticosis polydipsia, lung-heat type cough,
Osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.Shennong's Herbal: master quenches one's thirst and hankers, remove pathogenic factor limbs edema, lower water, mends not
Foot, QI invigorating.Compendium of Material Medica: kidney hardship is dry, preferably eat pungent to moisten it；Lung hardship is inverse, preferably eats hardship to rush down it.Working hard of the Rhizoma Anemarrhenae is cold and cool, under
Then profit kidney is dry and YIN nourishing, on then lung heat clearing gold pathogenic fire purging, be two through edema caused by disorder of QI medicine." book on Chinese herbal medicine justice ": Rhizoma Anemarrhenae Han Run, only controls excess-fire, rushes down
Lung stops up heat to let out, lung abscess cough caused by dryness preferably it, and deficiency-heat cough is avoided greatly.This product has clear purte the white, the effect of nourishing YIN and moistening the lung containing zhimusaponin.
There is the effect of resisting pathogenic microbes, to staphylococcuses, Bacillus typhi, pasteurellosis bacilluss, Salmonella paratyphi, escherichia coli etc. have not
Inhibitory action with degree.Additionally, having effect that is antipyretic and adjusting 17-hydroxy-11-dehydrocorticosterone.
Bulbus Fritillariae Thunbergii: for the bulb of Liliaceae herbaceos perennial Bulbus Fritillariae Thunbergii.Main product is in Xiangshan of Zhejiang Province, Yinxian County, Anhui, river
The ground such as Soviet Union also produce.Produce Zhejiang Province and claim Bulbus Fritillariae Thunbergii, also known as Bulbus Fritillariae Thunbergii.Bitter in the mouth, cold in nature.Return lung, heart channel.Effect removing heat-phlegm, dissipating depression of QI
Eliminating stagnation." book on Chinese herbal medicine is just ": control greatly lung abscess lung and wither, cough with asthma, spit blood, epistaxis, drops mental disorder, kind relieving stagnation, relieve the pain pain, relieving distension is full, clearly most
Liver-fire, bright knowledge, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, hematuria of having blood in stool；Relieving heat toxin, kills parasites and treats sore throat, scrofula, acute mastitis carbuncle on the back,
All large carbuncle pyogenic infections, damp and hot malignant boil, anal fistula, incised wound bleeding, burn pain, than Bulbus Fritillariae Cirrhosae, the work(of clear fall, not less than several times." this
Grass is from new ": feel wind-phlegm when going." detailed outline is picked up any lost article from the road ": the sharp expectorant of removing toxic substances, open lung qi dispersing gas, all lung men folder wind-fire has expectorant person preferably this." Shandong
Chinese herbal medicine handbook ": removing heat from the lung and dissipating phlegm, antacid, removing toxic substances.Cure cold cough, acid regurgitation of having a stomachache, and carbuncle poison swells and ache.Bulbus Fritillariae Thunbergii has cough-relieving
The effect of expectorant is relatively strong, and has functions that heat-clearing and toxic substances removing and lung moistening, and abundant expectoration expectorant all can use less, caused by being particularly well-suited to the dryness of the lung or autumn-dryness disease
Cough.Cough, mouth and nose drying, dry throat and mouth etc. can be alleviated, there is certain pathogenic fire purging and antiinflammatory, antiviral in addition
And antineoplastic action.Modern pharmacological research confirms, Bulbus Fritillariae Thunbergii contains multiple alkaloid such as peimine, and peimine can be alleviated
Bronchial muscular spasm, reduce bronchial mucosa secretion, expand pupil, reduce blood pressure, the multiple pharmacological effect such as excited uterus.
Radix Platycodoniss: bitter in the mouth, pungent, mild-natured.Return lung warp.Effect lung qi dispersing, sore-throat relieving, eliminating the phlegm, evacuation of pus.Radix Platycodoniss contain kikyosaponin, hydrolysis
Generation ruscogenin is triterpene acid blend: Polygalacic acid, platycodigenin and inulin, platycodonin, glucose, plant sterol etc.
Modern study confirms that it has stronger phlegm-dispelling functions, antitussive effect and antiinflammatory action: contained platycodin is to oral cavity, pharynx
Throat position, the direct stimulation of gastric mucosa, reflexive ground increases bronchial mucosa hypersecretion so that sputum dilution is it is easy to arrange
Go out；Radix Platycodoniss have antitussive effect, have enhancing antiinflammatory and immunization.
Cortex Magnoliae Officinalis: bitter in the mouth, pungent, warm in nature.Returns spleen, stomach, lung, large intestine channel.Effect eliminating dampness dissolving phlegm, lower gas removes full.For humidity hysteresis wound
In, gastral cavity ruffian is vomited and diarrhoea, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm and retained fluid is breathed with cough.Shennong's Herbal: main apoplexy typhoid fever, headache, cold and heat, shy
Throb with fear, QI and blood numbness, dead flesh, goes three worms.Cortex Magnoliae Officinalis contains magnolol, has functions that circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma.Cortex Magnoliae Officinalis
Decoct has stronger antibacterial action to staphylococcuses, streptococcus, bloody dysentery bacillus, pasteurellosis bacilluss, vibrio cholera；And to striped muscle
Tetanic also have certain mitigation.
Pericarpium Citri tangerinae: acrid in the mouth and slight bitter, temperature, enter spleen, lung meridian.Indication: in reasonable controlled atmosphere, drying dampness to eliminate phlegm effect, can be used for
Treatment stagnation of QI in spleen and stomach, distension and fullness in the abdomen, vomiting, or uncomfortable in chest caused by turbid damp obstructing in middle-JIAO, indigestion and loss of appetite, loose stool, but YIN fluid deficiency, the person that inside has excess-heat
Use with caution." medical center bun will ": Pericarpium Citri tangerinae, on then eliminating the pathogens from the lung evil, lowering the adverse flow of QI；In then dry spleen wet, and middle gas；Under then soothing liver-QI wood, profit kidney life.Main
In pleasant, expectorant, go strongly fragrant.Pericarpium Citri tangerinae 1.9%～3.5%. containing volatile oil is mainly limonene.There is eliminating phlegm and relieving asthma effect, additionally,
Pericarpium Citri tangerinae has resisting pathogenic microbes to act on, and can suppress staphylococcic growth, and can reduce blood capillary with antiinflammatory, antiallergic
Gutron permeability, prevents microvascular bleeding；Can be increased with the vascular permeability that antagonizing histamine, LYSOLECITHIN SUNLECITHIN A cause.
Bombyx Batryticatus: acrid in the mouth is salty, mild-natured.Enter liver, lung, stomach.Indication: expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia,
Infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind sore urticaris, erysipelas, mastitis." this warp ": main pediatric epilepsy scared night cry, go three
Worm, goes out black, man's the moon infectionss disease." Japan hanako materia medica ": control apoplectic aphasia, and a wind cutting disease, convulsive seizure induced by terror in children, man's pudendal pruritus pain,
Woman's leukorrhagia." medicine origin ": remove all wind between skin." detailed outline ": scattered wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind
Skin ulcer, erysipelas is had an itch, and intermittent fever due to phlegm is tied, married woman's galactostasiss, metrorrhagia hematochezia, and children's infantile malnutrition loses squama body, all incised wounds, and furuncle swells wind hemorrhoid." beautiful
Chinese catalpa medicine solution ": active stimulate the menstrual flow, wind dispelling opens numbness.Control the headache thoracic obstruction, locked mouth is had a toothache, urticaria wind scabies；Burning grinds wine clothes, and carbuncle of bursting breaks top, and
Control stranguria with blood metrorrhagia.
Periostracum Cicadae: sweet in the mouth, cold in nature.Return lung, Liver Channel.Indication: scattered wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For wind
Thermal sensation emits, pharyngalgia, hoarseness, measles without adequate eruption, rubella itch, cataract, convulsion with spasms, tetanus." not Lu ": main children's epilepsy；
The main chronic dysentery of grey clothes." haigoushen ": control children's high fever infantile convulsion from head to foot, and can quench the thirst." detailed outline ": control phlegm-accumulating vertigo, skin wind heat,
Varioliform exanthema is had an itch, tetanus and treat toxic swelling skin ulcer, adult's aphonia, and children's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature.Enter stomach, large intestine, Liver Channel.Indication: purge heat poison, removing mass is stagnant, clots absorbing blood.Control excess-heat just
Secret, delirium sends out support, food stagnation feeling of fullness, and dysentery from the beginning of, tenesmus, close, lump in the abdomen by stasis of blood menolipsis, when row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, tell
Blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, also urinate, large carbuncle pyogenic infections, furuncle, burn." this warp ": lower blood stasis, blood closes, cold and heat, broken disease
Abdominal mass is gathered, and prolonged fluid-retention dyspepsia cleanses the intestines and stomach, pushes away Chen Zhixin, tonneau water paddy, relieving dyspepsia in tune, peace and the five internal organs." not Lu ": flat stomach, under
Gas, expectorant is real, stagnation of pathogenic heat between intestinal, trusted subordinate's distension, and the cold blood of woman closes swollen, lower abdominal pain, and all old blood stays knot." haigoushen ": main cold and heat, disappear
Food, refines the five internal organs, and through waiting, diuretic swells logical woman, and broken expectorant is real, cold and hot accumulation, dyspepsia, sharp intestine and small intestine, and patch pyretic toxicity swells, main children's cold and heat
Shi Ji, dysphoria with smothery sensation, lose pus, broken stagnant blood." Japan hanako materia medica ": " lead to and declare all gas, blood circulation regulating, sharp joint, let out and mould stagnant, aqueous vapor, extremity
Unbalanced cold and heat, warm miasma heat-phlegm, sharp defecation, and apply-cut furuncle carbuncle poison." detailed outline ": also cure mainly dysentery in vain, pain in the abdomen is suffered from abdominal pain, urine
Drench drip, excess-heat dryness accumulated in the stomach and intestine, hectic fever delirium, jaundice, all burn.
Rhizoma Curcumae Longae: acrid in the mouth is bitter, warm in nature.Indication: removing blood stasis, circulation of qi promoting, stimulate the menstrual flow, pain relieving.Control trusted subordinate's feeling of fullness distending pain, brachialgia, disease
Abdominal mass, women's blood stasis is through closing, puerperal, the stasis of blood stopped suffering from abdominal pain, injury from falling down, carbuncle.Tang Materia Medica: main trusted subordinate's knot is long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, breaks
Blood, except wind heat, subduing inflammation.Power strong in Radix Curcumae." Japan hanako materia medica ": control lump in the abdomen clot, carbuncle, logical menstruation, control to fall and flutter blood stasis,
Detumescence poison；Only storm wind pain cold air, lower food." book on Chinese herbal medicine is just ": except the depressed flatulence of trusted subordinate, cold air food stagnation pain." book on Chinese herbal medicine is stated ": control gas card
Syndrome of feeling fullness and distension in the upper abdomen, distension breathes heavily choke, gastric abscess, the abdomen side of body shoulder back of the body and brachialgia, numbness, hernia." medical center bun is wanted ": control the anemofrigid-damp arthralgia of extremity." modern real
With Chinese medicine ": for fragrant stomachic, the disinfective action of favourable biliary tract and liver.For jaundice, the vexed pain of fullness in the chest painful abdominal mass.It is hemostasis again
Agent, controls haematemesis, epistaxis, hematuria, and controls haemorrhoids.It is used for outward abscess wound.
The invention has the beneficial effects as follows:
Medicine of the present invention is based on China's Chinese medicine to pathogenetic understanding and the Therapeutic Principle of generating heat, and grinds with reference to modern pharmacology
Study carefully achievement, make Chinese medicine preparation by Chinese veterinarian's theory prescription.By two female dissipate and Hoisting powder based on prescription, have ascending the clear and descending the turbid, clearly
Remove stagnant heat, lung qi dispersing eliminating the phlegm, lowering the adverse-rising QI to subdue asthma the effect of.This medicine enhances the integrally-regulated function of animal body, can effectively alleviate
Respiratory symptom, eliminates or substantially mitigates the inflammatory pathology damage of the histoorgans such as upper respiratory tract, pulmonary, and decreasing chemical medicine may
The potential safety hazard causing, increased the safety of medication.
Present invention offer is a kind of to treat pig, poultry, the medicine of cattle and sheep respiratory tract disease.Specifically with the Rhizoma Anemarrhenae, Bulbus Fritillariae Thunbergii
The herbal medicine patent medicine that mother, Radix Platycodoniss, Cortex Magnoliae Officinalis, Pericarpium Citri tangerinae, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei etc. are prepared for raw material to treat or alleviate due to
The lung heat cough and asthma that pathogen or external environment lead to.For porcine respiratory disease complex etc. is cough caused, dyspnea, appetite
Go down, the speed of growth reduces, efficiency of feed utilization reduces the disease being characterized.Medicine of the present invention is studied through for many years, clinical treatment
Effect substantially, the features such as having that formula is rigorous, good effect, cure rate are high, have no side effect, has good economy and society's effect
Benefit.
Specific embodiment
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Rhizoma Anemarrhenae 150g, Bulbus Fritillariae Thunbergii 150g, Radix Platycodoniss 150g, Cortex Magnoliae Officinalis 150g, Pericarpium Citri tangerinae 150g, Bombyx Batryticatus 50g, Periostracum Cicadae 50g, Rhizoma Curcumae Longae 100g,
Radix Et Rhizoma Rhei 50g.
The preparation method of granule is as follows:
Take the medical materials such as the Rhizoma Anemarrhenae, Bulbus Fritillariae Thunbergii, Radix Platycodoniss, Cortex Magnoliae Officinalis, Pericarpium Citri tangerinae, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei to add 10 times amount decoctings to boil three times,
2 hours every time, merge decoction liquor, filtration, stand overnight, leaching supernatant, be evaporated to relative density 1.24 (50 DEG C), dry
Dry one-tenth dry cream.Dry cream pulverized 100 mesh sieves, added appropriate dextrin 300g and cane sugar powder 400g, mixes, granule processed, granulate, makes
1000g, subpackage obtains final product.
Embodiment 2
Rhizoma Anemarrhenae 300g, Bulbus Fritillariae Thunbergii 300g, Radix Platycodoniss 300g, Cortex Magnoliae Officinalis 300g, Pericarpium Citri tangerinae 300g, Bombyx Batryticatus 250g, Periostracum Cicadae 200g, Rhizoma Curcumae Longae
300g, Radix Et Rhizoma Rhei 200g.
The preparation method of tablet is as follows:
Take the medical materials such as the Rhizoma Anemarrhenae, Bulbus Fritillariae Thunbergii, Radix Platycodoniss, Cortex Magnoliae Officinalis, Pericarpium Citri tangerinae, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei to add 10 times amount decoctings to boil 2 times,
1.5 hours every time, merge decoction liquor, filtration, stand overnight, leaching supernatant, be evaporated to relative density 1.22 (50 DEG C),
It is dried to dry cream.Dry cream pulverized 100 mesh sieves, added appropriate dextrin and stevioside, mixed, and pelletized, and added magnesium stearate to mix
Close, tabletting 2500, obtain final product.
Embodiment 3
Rhizoma Anemarrhenae 200g, Bulbus Fritillariae Thunbergii 200g, Radix Platycodoniss 200g, Cortex Magnoliae Officinalis 200g, Pericarpium Citri tangerinae 200g, Bombyx Batryticatus 150g, Periostracum Cicadae 120g, Rhizoma Curcumae Longae
200g, Radix Et Rhizoma Rhei 120g.
The preparation method of capsule is as follows:
Take the medical materials such as the Rhizoma Anemarrhenae, Bulbus Fritillariae Thunbergii, Radix Platycodoniss, Cortex Magnoliae Officinalis, Pericarpium Citri tangerinae, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei to add 12 times amount decoctings to boil 1 time,
1 hour every time, merge decoction liquor, filtration, stand overnight, leaching supernatant, be evaporated to relative density 1.20 (50 DEG C), dry
Dry one-tenth dry cream, dry cream pulverized 100 mesh sieves, added appropriate dextrin and saccharin sodium, mixed, and pelletized, and encapsulated obtained final product.
Embodiment 4
Rhizoma Anemarrhenae 300g, Bulbus Fritillariae Thunbergii 300g, Radix Platycodoniss 300g, Cortex Magnoliae Officinalis 300g, Pericarpium Citri tangerinae 300g, Bombyx Batryticatus 250g, Periostracum Cicadae 200g, Rhizoma Curcumae Longae
300g, Radix Et Rhizoma Rhei 200g.
The preparation method of powder is as follows:
Take the Rhizoma Anemarrhenae, Bulbus Fritillariae Thunbergii, Radix Platycodoniss, Cortex Magnoliae Officinalis, Pericarpium Citri tangerinae, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, rhubarb medicinal material to pulverize 80 mesh sieves respectively, weigh
Mix, obtain final product.
The clinical efficacy to pig prdc for test example 1 medicine of the present invention
Experimental animal: about certain pig farm 13 week old, DLY tri-crossbreeding occurs groupment porcine respiratory disease syndrome
(prdc), clinical symptoms occur breathing, cough, generate heat for pig, inappetence or no appetite.Choosing wherein 40, through nosetiology glass
Piece agglutination test, is diagnosed as the prdc that pasteurella multocida disease leads to.It is then separated into 2 groups, every group 20.Divide Chinese medicine group and celebrating
Big mycin group.
Evaluation criterion is: cures: after medication one week, pig clinical symptom disappearance, and spirit and appetite recover normal.Effective: to exhale
Desorption system symptom mitigation, appetite takes a turn for the better.Invalid: Respiratory symptoms do not mitigate or aggravate, become thin, be dehydrated, spirit, loss of appetite
Or it is useless exhausted.Treated through one week, Chinese medicine group is as follows to pig prdc therapeutic effect:
The clinical efficacy to pig prdc for table 1 medicine of the present invention
| Packet | Number of cases | Cure | Effectively | Invalid | Cure rate | Total effective rate |
| Embodiment 2 | 30 | 20 | 8 | 2 | 66.67% | 93.33% |
| Matched group 1 | 30 | 18 | 8 | 4 | 60.00% | 86.67% |
| Matched group 2 | 30 | 14 | 10 | 6 | 46.67% | 80.00% |
Matched group 1 adopts cn201511028773.1 embodiment 2 sample；
Matched group 2 is treated using conventional western medicine (gentamycin)；
Result of the test shows, this Chinese medicine compound has good curative effect to pig prdc disease.
The clinical efficacy to chicken ib for test example 2 medicine of the present invention
For trying chicken house: Beijing chicken farm.For trying chicken group: 20 ages in days, aa meat sold on the market chicken.Chicken group's quantity: 3000, same to group
With giving up, feeding and management condition is identical, because winter warming measure is bad, ventilation does not freely induce this disease.
Test group: using the spice treatment of the embodiment of the present invention 4 powder.Weigh 1000g this product, spice 200kg, mix thoroughly,
Appoint chicken group's free choice feeding, continuous use 4 days.
Western medicine group: 1000, using commercially available Western medicine cough with asthma is quick, moroxydine hydrochloride, doxycycline symptomatic treatment.Cough with asthma
Quick (0.02g/ is only), common 20g, moroxydine hydrochloride (0.01g/ is only), common 10g, doxycycline (50mg/ is only), common 50g, plus 10l is clear
Clean tap water, freely drinks for chicken group after mixing, continuous use 4 days.
Chinese medicine matched group: weigh 1000g Antiphlogistic Powder of Schizonepetae and Ledebouriellae (1g/ is only), spice 200kg, mix thoroughly, appoint chicken group's free choice feeding,
Continuous use 4 days.
The clinical efficacy to chicken ib for table 2 medicine of the present invention
| Packet | Number of cases | Death toll | Cure number | Mortality rate | Cure rate |
| Test group | 1000 | 47 | 953 | 4.7% | 95.3% |
| Western medicine group | 1000 | 188 | 812 | 18.8% | 81.2% |
| Chinese medicine matched group | 1000 | 113 | 887 | 11.3% | 88.7% |
Result shows: test group reduces by 14 and 6.6 percentage points than the mortality rate of western medicine group and Chinese medicine matched group respectively.
Claims (4)
1. a kind of Chinese medicine composition of preventing and treating livestock and birds respiratory disease is it is characterised in that prepared by the crude drug of following weight proportion
Form: Rhizoma Anemarrhenae 15-30 part, Bulbus Fritillariae Thunbergii 15-30 part, Radix Platycodoniss 15-30 part, Cortex Magnoliae Officinalis 15-30 part, Pericarpium Citri tangerinae 15-30 part, Bombyx Batryticatus 5 ~ 25
Part, 5 ~ 20 parts of Periostracum Cicadae, 10 ~ 30 parts of Rhizoma Curcumae Longae, 5 ~ 20 parts of Radix Et Rhizoma Rhei.
2. compositionss according to claim 1 are it is characterised in that be prepared from by the crude drug of following weight proportion: the Rhizoma Anemarrhenae
20 parts, 20 parts of Bulbus Fritillariae Thunbergii, 20 parts of Radix Platycodoniss, 20 parts of Cortex Magnoliae Officinalis, 20 parts of Pericarpium Citri tangerinae, 15 parts of Bombyx Batryticatus, 12 parts of Periostracum Cicadae, 20 parts of Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei 12
Part.
3. compositionss according to claim 1 are it is characterised in that described dosage form is selected from: tablet, capsule, granule, ball
Agent, powder, unguentum, oral solutionses, injection, suppository, spray, drop, patch.
4. a kind of preparation method of the compositionss described in claim 1 is it is characterised in that step is as follows: takes the Rhizoma Anemarrhenae, Bulbus Fritillariae Thunbergii, Fructus Citri tangerinae
Stalk, Cortex Magnoliae Officinalis, Pericarpium Citri tangerinae, Bombyx Batryticatus, Periostracum Cicadae, Rhizoma Curcumae Longae, rhubarb medicinal material add 8-12 times amount decocting boil or 40%-70% alcohol reflux 2-
3 times, each 1-2 hour, united extraction liquid, filtration, stand overnight, leaching supernatant, be evaporated to relative density 1.16～
1.24 (50 DEG C), it is dried to dry cream, dry cream pulverized 100 mesh sieves, add appropriate amount of auxiliary materials, make compositionss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610912761.3A CN106344876A (en) | 2016-10-20 | 2016-10-20 | Traditional Chinese medicine composition for controlling livestock/poultry respiratory diseases and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610912761.3A CN106344876A (en) | 2016-10-20 | 2016-10-20 | Traditional Chinese medicine composition for controlling livestock/poultry respiratory diseases and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106344876A true CN106344876A (en) | 2017-01-25 |
Family
ID=57863508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610912761.3A Pending CN106344876A (en) | 2016-10-20 | 2016-10-20 | Traditional Chinese medicine composition for controlling livestock/poultry respiratory diseases and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106344876A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686047A (en) * | 2018-08-17 | 2018-10-23 | 广西大学 | A kind of Traditional Chinese medicinal spray and the preparation method and application thereof of prevention sheep breathing problem |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977314A (en) * | 2014-05-20 | 2014-08-13 | 李果 | Medicinal composition for treating respiratory diseases as well as preparation method and application of medicinal composition |
| CN104922412A (en) * | 2015-07-08 | 2015-09-23 | 李学军 | Traditional Chinese medicine for treating laying hen respiratory tract diseases |
| CN105535406A (en) * | 2015-12-31 | 2016-05-04 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for preventing and treating livestock respiratory disease |
-
2016
- 2016-10-20 CN CN201610912761.3A patent/CN106344876A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977314A (en) * | 2014-05-20 | 2014-08-13 | 李果 | Medicinal composition for treating respiratory diseases as well as preparation method and application of medicinal composition |
| CN104922412A (en) * | 2015-07-08 | 2015-09-23 | 李学军 | Traditional Chinese medicine for treating laying hen respiratory tract diseases |
| CN105535406A (en) * | 2015-12-31 | 2016-05-04 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for preventing and treating livestock respiratory disease |
Non-Patent Citations (1)
| Title |
|---|
| 余茂清: "升降散对猪病的应用", 《中兽医学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686047A (en) * | 2018-08-17 | 2018-10-23 | 广西大学 | A kind of Traditional Chinese medicinal spray and the preparation method and application thereof of prevention sheep breathing problem |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104187172B (en) | Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed | |
| CN104435944A (en) | Traditional Chinese medicine composition for treating infantile cough and preparation method thereof | |
| CN1251732C (en) | Chinese medicine for treating intrapulmonic infection and SARS | |
| CN103638361B (en) | Medicine for treating cough and preparation method of medicine | |
| CN102698158B (en) | Traditional Chinese medicine for preventing and treating infectious bronchitis, preparation method thereof and feed | |
| CN105233116A (en) | Traditional Chinese medicine composition for preventing and controlling respiratory tract infection of chicken and preparation method thereof | |
| CN103494927A (en) | A kind of traditional Chinese medicine composition for treating poultry respiratory disease and preparation method thereof | |
| CN103417875B (en) | A kind of Chinese medicine preparation for the treatment of chronic bronchitis and preparation method thereof | |
| CN103656145B (en) | Medicine being used for the treatment of pig lung plague and preparation method thereof | |
| CN103263654B (en) | Medicine for treating lobar pneumonia and preparation method thereof | |
| CN105497723A (en) | Traditional Chinese medicine preparation for treating bacterial pneumonia and preparation method thereof | |
| CN103341151B (en) | Traditional Chinese medicine for treating chronic bronchitis | |
| CN105663575A (en) | Traditional Chinese medicine composition for preventing and treating swine fever and preparation method of traditional Chinese medicine composition | |
| CN105878716B (en) | A Chinese herbal compound preparation for preventing and treating chicken hydropericardium syndrome | |
| CN104815151A (en) | Traditional Chinese medicine for treating warm-dryness lung injury type cough | |
| CN104147575A (en) | Traditional Chinese medicine preparation for treating wind-cold lung-closure-type chronic bronchitis and preparation method thereof | |
| CN103829104B (en) | Feed for treating cold cough of chicken and preparation method of feed | |
| CN103830713B (en) | Medicine for treating chicken wind-cold type cough and asthma and preparation method thereof | |
| CN103623192B (en) | Medicine being used for the treatment of pig blue-ear disease and preparation method thereof | |
| CN103230580A (en) | Traditional Chinese medicine composition for preventing and treating infectious serositis of duck | |
| CN107960535A (en) | A kind of feed addictive and its production method for preventing beef cattle gastroenteritis | |
| CN105267687A (en) | Traditional Chinese medicine preparation for treating acute tonsillitis and preparation method thereof | |
| CN106074779A (en) | A kind of medicated wine treating burn and scald | |
| CN106692764A (en) | Medicine for treating scarlatina and preparation method of medicine | |
| CN106389803A (en) | Traditional Chinese medicine composition for preventing and controlling cough and asthma of piglet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170125 |
|
| RJ01 | Rejection of invention patent application after publication |