CN105395835A - Traditional Chinese medicine composition used for treating escherichia coli infection in brooding stage of poultry - Google Patents
Traditional Chinese medicine composition used for treating escherichia coli infection in brooding stage of poultry Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition preventing and treating escherichia coli infection in the brooding stage of poultry. According to the dialectical characteristics of escherichia coli infection in the brooding stage of poultry, ophiopogon japonicus for nourishing yin and generating body fluid and rehmannia roots for cooling blood and nourishing yin jointly serve as monarch medicine, radix berberidis for purging intense heat and removing toxic matter serves as minister medicine, and astragalus for benefiting qi and strengthening superficies, atractylodes for strengthening the spleen and benefiting qi and licorice for tonifying the spleen and benefiting qi together serve as assisting and guiding medicine. On one hand, the cold properties of the monarch and minister medicine are relieved, and on the other hand, the medicine has the functions of consolidating the basis and can meet the requirement of effectively preventing and controlling escherichia coli infection on the premise that the internal organs of young poultry are immature in the growth and development stage of the young poultry. As shown by a larger amount of clinical application to poultry diseases, the traditional Chinese medicine composition has the advantages that the effect is exact, toxic and side effects are avoided, and medicine residuals are avoided.
Description
Technical field
The invention belongs to veterinary drug preparation to produce and application, relate to a kind of Chinese medicine composition, especially relate to a kind of Chinese medicine composition preventing and treating poultry in brood time coli-infection.
Background technology
Poultry in brood time is the most responsive in the poultry whole culture-cycle, is also the very crucial nurturing period.Young fowl is from going out shell to 10 ages in days, and its digestive system is grown rapidly, and forms metastable microecological balance gradually.In clinical practice, the topmost bacterial disease of brood time is colibacillary infection, and the infection in this period is obviously different from adult poultry colibacillosis.The source of infection is mainly derived from the vertical transmission of yolk at first, and along with yolk is absorbed, escherichia coli directly enter blood and infect.In chickling sawing sheet link, cause of disease, along with the excretion of meconium, forms horizontal transmission again.Thus, characteristics of incidence and the adult poultry of poultry in brood time colibacillosis are totally different, often occur that batch was dead at 3-5 days that infect.At present, control the brood time bacteriological infection overwhelming majority and rely on antibacterials.But the use of antibacterials can disturb the foundation of young bird digestive tract Tiny ecosystem undoubtedly.Under the pressure of antibacterials, the bacterial strain only carrying drug resistant gene could successfully field planting in digestive tract, thus drug resistance is strengthened day by day.Thus, under avoiding brood time to use the prerequisite of antibacterials in a large number, effectively control colibacillary infection, be alleviate resistance development in the poultry farming whole cycle, guarantee to cultivate successful key.
Because e. coli serotype is a lot, between different serotypes, cross-protection is limited, and the application of bacterial vaccine is still difficult to there is larger breakthrough in a short time.On the other hand, comparatively early, the immunoreation of inactivated vaccine often has little time to play a protective role the morbidity of brood time escherichia coli.Thus, suitable Chinese prescription is selected to become one of effective way effectively controlling brood time coli-infection.
In recent years, a lot of report has also been had about Chinese medicine in the preventing and treating of the bacterial infections such as family's avian escherichia coli.But the Chinese prescription preventing and treating poultry in brood time coli-infection at present remains in some problems.By the dialectical theory of Chinese veterinarian, generally avian colibacillosis is interpreted as the interior-heat syndrome that damp and hot heap soil or fertilizer over and around the roots is amassed intestinal and caused, should heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping.For adult poultry colibacillosis, this is dialectical should be all right, but is then not suitable for for young bird colibacillosis.As previously mentioned, the colibacillosis of vertical transmission, cause of disease directly enters blood by yolk; The link of horizontal transmission, because young bird internal organs are tender, hedge is sparse, battalion Wei Bugu, exopathogen very easily enters blood heat-transformation and affects battalion's the moon.Thus the infection of brood time colibacillosis shows particularly dangerous, often mortality in a few days.So it is cloudy that brood time colibacillosis dialectical should be pathogenic heat battalion of caving in, and accumulative internal organs gradually, based on the heart, liver, kidney.This dialectical and dead young bird is based on the pathological changes of the heart, liver, kidney, and the inspection symptom of cuing open of rarely seen intestinal pathological changes matches.Thus, the Chinese prescription of brood time colibacillosis should be the basic rule for the treatment of with clearing away heat from YING and blood systems, and is not heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping.Secondly, what reported at present take heat-clearing and toxic substances removing as the prescription of the basic rule for the treatment of, the multiselect medicine of the bitter colds such as Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, be bound to this just relatively weak cloudy Tianjin of loss young bird, although the death of bacteriological infection can be controlled to a certain extent, but often have a strong impact on the growth promoter of young bird, cause later stage fertility performance to reduce.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to the physiological characteristics of growing according to young fowl, by prescription again after studying Chinese medicine pharmacology, provide a kind of Chinese medicine composition preventing and treating brood time coli-infection.Said composition as a kind of pure Chinese medicinal preparation, to effectively control brood time coli-infection, and reduce antibacterials in poultry farming process use, delay bacterial resistance sexual development, reduce drug residue etc. significant.
In order to solve the problem existing for background technology, the present invention is by the following technical solutions:
For preventing and treating a Chinese medicine composition for brood time coli-infection, formed by the active fraction preparation of following weight portion: Radix Ophiopogonis 30-60 part, Radix Rehmanniae 25-45 part, Radix Berberidis 15-30 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Radix Astragali 10-25 part, Radix Glycyrrhizae 10-20 part.
Preferably, the described Chinese medicine composition for preventing and treating brood time coli-infection, is formed by the active fraction preparation of following weight portion: Radix Ophiopogonis 30-50 part, Radix Rehmanniae 25-35 part, Radix Berberidis 15-25 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Astragali 10-20 part, Radix Glycyrrhizae 10-15 part.
Further preferably, the described Chinese medicine composition for preventing and treating poultry in brood time coli-infection, is formed by the active fraction preparation of following weight portion: Radix Ophiopogonis 30-45 part, Radix Rehmanniae 25-30 part, Radix Berberidis 15-20 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Astragali 15-20 part, Radix Glycyrrhizae 10-15 part.
The present invention presses the Chinese powder medicine of the general production technology manufacture of veterinary drug powder, fed by spice or boiled water punching is stewing, decoct after feed for poultry, in case control poultry in brood time coli-infection.
The present invention becomes oral liquid by the general production technology manufacture of veterinary drug oral liquid, also can become Chinese medicine granules according to veterinary drug granule technological process of production manufacture.
Therefore, the described Chinese medicine composition for preventing and treating poultry in brood time coli-infection, it is powder, granule or oral liquid.Described poultry is laying hen, broiler, turkey, laying ducks, meat-type duck, goose and Carnis Coturnicis japonicae.
Record according to TCM Literature (China's book on Chinese herbal medicine), above-mentioned 6 taste Chinese crude drugs have following pharmacologically active and function cures mainly:
Radix Ophiopogonis: the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogonjaponicus (Thunb.) Ker-Gawl..Sweet, micro-hardship, is slightly cold, GUIXIN, lung, stomach warp.Function YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Radix Rehmanniae: be the rhizome of scrophulariaceae rehmannia glutinosa plant Rehmanniaglutinosa (Gaertn.).Sweet in the mouth is bitter, cold in nature; GUIXIN, liver, kidney channel.Function clearing away heat and cooling blood; Promote the production of body fluid and moisturize.
Radix Berberidis: for Berberidaceae plant stings root bark or the peel of stem of black pearl, berberis brachypoda Maxim, black stone pearl etc.Bitter in the mouth, cold in nature, return liver, stomach, large intestine channel.Function heat clearing away; Dampness; Eliminating fire and detoxication.Main dysentery due to damp-heat profit; Diarrhoea.
The Radix Astragali: be the root of leguminous plant Radix Astagali Astragalusmembranaceus (Fisch.).Property is sweet, tepor.Return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, the diseases such as chronic diarrhea proctoptosis.
The Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz..Property bitter, sweet, temperature.Return spleen, stomach warp.Effect invigorating the spleen and benefiting QI, dampness diuretic.The disease such as to have loose bowels for insufficiency of the spleen lack of appetite, abdominal distention.
Radix Glycyrrhizae: be the dry root of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL..Property sweet, flat, GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Compared with prior art, what the present invention relates to has the following advantages and marked improvement for the Chinese medicine composition tool preventing and treating poultry in brood time coli-infection: 1. prescription of the present invention is according to the dialectical feature of poultry in brood time coli-infection, with the Radix Rehmanniae of the Radix Ophiopogonis of YIN nourishing and the production of body fluid promoting and removing heat from blood YIN nourishing altogether for monarch drug, with the Radix Berberidis of eliminating fire and detoxication for minister.Although the three herbal medicines medicine that to be all bitter in the mouth cold in nature, avoid the bitter dry impairment of body fluid of property in the medicine such as Rhizoma Coptidis, Cortex Phellodendri large bitter Great Cold, the shortcoming of injuring spleen-stomach.2. Chinese medicine composition disclosed by the invention, with the Rhizoma Atractylodis Macrocephalae of the Radix Astragali of benefiting QI for strengthening the superficies, invigorating the spleen and benefiting QI, and the Radix Glycyrrhizae of invigorating the spleen and replenishing QI is altogether for assistant makes, and alleviates the cold of the medicine of the monarch and his subjects on the one hand, plays effect of vital base and primordial QI consolidating on the other hand.3. Chinese medicine composition disclosed by the invention is made up of by the principle of monarch 6 taste Chinese crude drugs, and raw material is simple and easy to get, and cost is lower, economic and practical.4. the present invention is pure Chinese medicinal preparation, effectively reduces antibiotic use in poultry farming process, and it is significant to reduce drug residue.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment one: the preparation of Chinese powder medicine
Chinese medicine composition by Radix Ophiopogonis 40 parts, Radix Rehmanniae 30 parts, Radix Berberidis 15 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, the Radix Astragali 15 parts, 10 parts, Radix Glycyrrhizae composition.Described each taste Chinese medicine is the prepared slices of Chinese crude drugs meeting " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.By each Chinese medicine co-grinding, cross 60 order spin vibration sieves, thicker Chinese medicinal granule is again pulverized, is sieved, and always mixed traditional Chinese medicine fine powder, is packed as 1kg/ bag, obtains final product.By the Chinese powder medicine that this method is produced, the mode of generally being fed by spice for the poultry such as broiler, laying hen, for the control of brood time coli-infection; Can also by stewing 30 minutes of the boiled water of this powder 8-10 times of weight portion punching, supernatant is drunk water, and medicinal residues spice, for the total effective rate more than 97% of poultry in brood time coli-infection.
Embodiment two: the preparation of Chinese medicine oral liquid
Chinese medicine composition by Radix Ophiopogonis 45 parts, Radix Rehmanniae 25 parts, Radix Berberidis 20 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, the Radix Astragali 15 parts, 10 parts, Radix Glycyrrhizae composition.Described each taste Chinese medicine is the prepared slices of Chinese crude drugs meeting " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Each Chinese medicine is dropped into extraction pot, add 10 times amount (weight ratio) purified water and soak 5 hours, be heated to boiling, be incubated 1 hour, wait and coldly leach supernatant, add 8 times amount (weight ratio) purified water again and be heated to boiling, be incubated 1 hour, filter, merge twice filtrate, being evaporated to crude drug than being 0.5kg/L, adding ethanol to final concentration 75% (volume ratio), precipitating 12 hours, supernatant heating recovery ethanol, and medicinal liquid is evaporated to crude drug than for 1kg/L, it is anticorrosion to add 0.3% sodium benzoate (W/V), fill, gland and get final product.By the Chinese medicine oral liquid that this method is produced, directly by application of drinking water after dilution, because Chinese medicine is through extraction process, onset feature rapidly can be had.
Embodiment three: the preparation of Chinese medicine granules
Chinese medicine composition by Radix Ophiopogonis 40 parts, Radix Rehmanniae 30 parts, Radix Berberidis 20 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, the Radix Astragali 16 parts, 12 parts, Radix Glycyrrhizae composition.Described each taste Chinese medicine is the prepared slices of Chinese crude drugs meeting " Chinese veterinary pharmacopoeia " related standards, and each ratio is weight portion.Each Chinese medicine is dropped into extraction pot, add 10 times amount (weight ratio) purified water and soak 5 hours, be heated to boiling, be incubated 1 hour, wait and coldly leach supernatant, add 8 times amount (weight ratio) purified water again and be heated to boiling, be incubated 1 hour, filter, merge twice filtrate, be evaporated to crude drug than being 0.5kg/L, add ethanol to final concentration 75% (volume ratio), precipitate 12 hours, supernatant heating recovery ethanol, and medicinal liquid is evaporated to crude drug than being 5kg/L (W/V), add suitable amount of sucrose and make soft material, granulate, dry, make the granule that crude drug content is 1kg/kg, subpackage and get final product.By Chinese medicine granules prepared by this method, warm water can melt during application, throw clothes by drinking-water, there is onset rapid, the features such as accumulating is convenient.
Embodiment four: the colibacillary clinical practice of traditional Chinese medicine composition for treating brood time
In order to verify the clinical efficacy of Chinese medicine composition of the present invention to poultry in brood time coli-infection further, selecting the broiler chicken of natural infection morbidity, providing antimicrobial drug for oneself as positive control medicine using plant, carried out contrast test.
1. materials and methods
1.1 test material
Chinese powder medicine, by method preparation described in embodiment 1; Chinese medicine oral liquid, by method preparation described in embodiment 2; Chinese medicine granules, by method preparation described in embodiment 3.
Positive control medicine: lincomycin hydrochloride-spectinomycin soluble powder is " the opening medicine " of this plant traditionally for brooding, by plant purchased from veterinary drug limited company of western Shandong.
Laboratory animal: same batch of identical hatchery 1 age in days Luo Si 308 commercial meat bird 72000 plumage.
1.2 test method
1 age in days Luo Si 308 commercial generation white meat-type chickens 72000 plumage, stochastic sampling cuts open inspection, laboratory is separated and makes a definite diagnosis coli-infection, is divided into 4 groups at random.
Positive controls 1 hen house, totally 18000 plumages, lincomycin hydrochloride-spectinomycin soluble powder by specification drinking water administration, every day 1 time, being used in conjunction 5 days is a course for the treatment of.
Chinese powder medicine group 1 hen house 18000 plumage, calculates dosage by 1.5g/kg body weight.Chinese powder medicine is directly admixed feedstuff and is fed, every day 1 time, and being used in conjunction 5 days is a course for the treatment of.
Chinese medicine oral liquid group and each 1 hen house of Chinese medicine granules group, enter young number and be 18000 plumages, with crude drug cubage, calculates dosage by 1.5g/kg body weight.Every day 1 time, being used in conjunction 5 days is a course for the treatment of.
2. result of the test
2.1 morbidity chicken public sentiment condition and diagnosis
In order to verify clinical effectiveness of the present invention when fitting and producing actual as far as possible, certain standardization plant of this experiment favour cultivation group in Shouguang, Shandong in place carries out.This plant has 8 standardization hen houses, and every hen house can raise commercial meat bird 18000 plumage, and facility and the management condition of every hen house are basically identical.Traditionally, chickling baby chick is introduced in the hatchery of large-scale livestock corporation from Shandong of this plant, and plumage, put into 4 hen houses respectively and cultivated every day 72000.8 hen houses need 2 chickens in the sky to terminate altogether.
The coli-infection of current chickling vertical transmission is very general.We find the shell baby chick sampling Detection that goes out deriving from several hatcheries, and baby chick carries colibacillary ratio roughly between 5-25%, and kind chicken house and hatchery management level obviously affect its bacterial bearing rate.
For 72000 plumage broiler baby chicks of this experiment, 200 plumages randomly drawed by every hen house, and disconnected neck is put to death, and cuts open and searches yolk sac, liver separating Escherichia coli, add up by institute's separation of bacterial quantity and ratio in yolk, judges vertical transmission situation thus.Result shows, escherichia coli bacterial bearing rate average out to 6.7%, does not have notable difference between each hen house baby chick.
2.2 contrast test
Similar with other scale livestock farming, the colibacillary infection of brood time is regular incidence, and the baby chick of each batch all exists the situation of vertical transmission.This plant adopts lincomycin hydrochloride-spectinomycin traditionally from 1 age in days, is used in conjunction dead washing in a pan of causing with this disease of prevention and control for 5 days.Through consulting with plant technical staff, curative effect contrast test is carried out to the hen house through detecting confirmation vertical transmission bacterial bearing rate basically identical.Wherein, 1 hen house adopts lincomycin hydrochloride-spectinomycin soluble powder, uses, as positive controls by veterinary drug description.Other 3 hen houses, Stochastic choice uses Chinese powder medicine, Chinese medicine granules and Chinese medicine oral liquid as experimental group respectively.Matched group and each experimental group all add up (1-14 age in days) in brood time death rate, deliver survival rate for sale, to deliver the index such as body weight, feedstuff-meat ratio for sale as shown in table 1.
Table 1 herbal mixture and antibacterial therapy Comparative result
* quantity delivered for sale by each hen house, and quantity is as the criterion " to hang chicken " with slaughterhouse
Due to the control situation of brood time bacterial infection, be directly connected to the growth uniformity of brood time chickling and the growth performance in later stage, thus, each large-scale plant all dare not attempt not using antibacterials at brood time.So this experiment can only be set using antibiotic positive controls, and cannot arrange and do not use antibiotic blank group.
From table 1, matched group and experimental group effectively can control the dead of brood time chickling and wash in a pan, and do not have notable difference between each group.Although each Chinese medicine experimental group does not have notable difference with antibiotic matched group in control brood time death rate, the growing state in later stage is all improved.Deliver survival rate for sale, deliver the aspect such as body weight and feedstuff-meat ratio for sale, Chinese drug-treated group is all better than antibiotic matched group.In addition, in feeding process, compared with antibiotic matched group, each Chinese drug-treated group incidence is also few a lot, and correspondingly, the drug use cost that infection control spends also reduces greatly.
Experiment confirms, Chinese prescription of the present invention effectively can control the colibacillary infection of brood time, and has good effect to the growth performance in later stage.
Claims (5)
1. prevent and treat a Chinese medicine composition for poultry in brood time coli-infection, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Radix Ophiopogonis 30-60 part, Radix Rehmanniae 25-45 part, Radix Berberidis 15-30 part, Rhizoma Atractylodis Macrocephalae 15-30 part, Radix Astragali 10-25 part, Radix Glycyrrhizae 10-20 part.
2. the Chinese medicine composition for preventing and treating poultry in brood time coli-infection according to claim 1, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Radix Ophiopogonis 30-50 part, Radix Rehmanniae 25-35 part, Radix Berberidis 15-25 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Radix Astragali 10-20 part, Radix Glycyrrhizae 10-15 part.
3. the Chinese medicine composition for preventing and treating poultry in brood time coli-infection according to claim 2, it is characterized in that: this Chinese medicine composition is formed by the active fraction preparation of following weight portion: Radix Ophiopogonis 30-45 part, Radix Rehmanniae 25-30 part, Radix Berberidis 15-20 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Astragali 15-20 part, Radix Glycyrrhizae 10-15 part.
4. the Chinese medicine composition for preventing and treating poultry in brood time coli-infection according to any one of claim 1-3, is characterized in that: this Chinese medicine composition is powder, granule or oral liquid.
5. the Chinese medicine composition for preventing and treating poultry in brood time coli-infection according to any one of claim 1-3, is characterized in that: described poultry is laying hen, broiler, turkey, laying ducks, meat-type duck, goose and Carnis Coturnicis japonicae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510975334.5A CN105395835A (en) | 2015-12-23 | 2015-12-23 | Traditional Chinese medicine composition used for treating escherichia coli infection in brooding stage of poultry |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105582037A (en) * | 2016-01-27 | 2016-05-18 | 成都乾坤动物药业有限公司 | Medicine composition for treating bacterial diseases of poultry |
| CN111358850A (en) * | 2020-04-26 | 2020-07-03 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating chicken colibacillosis and preparation method thereof |
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| CN102526356A (en) * | 2012-03-14 | 2012-07-04 | 青岛汉河动植物药业有限公司 | Traditional Chinese medicine compound for clearing Ying heat and cooling blood of poultry |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582037A (en) * | 2016-01-27 | 2016-05-18 | 成都乾坤动物药业有限公司 | Medicine composition for treating bacterial diseases of poultry |
| CN111358850A (en) * | 2020-04-26 | 2020-07-03 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating chicken colibacillosis and preparation method thereof |
| CN111358850B (en) * | 2020-04-26 | 2022-04-19 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating chicken colibacillosis and preparation method thereof |
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