CN103393891B - Antiviral compound traditional Chinese medicine for animals, and preparation method and use thereof - Google Patents

Antiviral compound traditional Chinese medicine for animals, and preparation method and use thereof Download PDF

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CN103393891B
CN103393891B CN201310345654.3A CN201310345654A CN103393891B CN 103393891 B CN103393891 B CN 103393891B CN 201310345654 A CN201310345654 A CN 201310345654A CN 103393891 B CN103393891 B CN 103393891B
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radix
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chinese medicine
herbal mixture
vitamin
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CN103393891A (en
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贾立华
吕淑荣
冷鲁南
姜莹
鲍捷
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Yantai aisijin Animal Health Products Co.,Ltd.
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YANTAI GREEN LEAF ANIMAL HEALTH PRODUCTS CO Ltd
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Abstract

The invention provides a compound traditional Chinese medicine, and a preparation method and an application thereof. The compound traditional Chinese medicine is composed of Radix aconiti lateralis preparata, Radix Scrophulariae, Acorus gramineus, radix paeoniae rubrathe, Herba Taraxaci, Herba Lycopi, Rubia cordifolia, Dioscorea tokoro Makin and licorice root. The invention also provides the preparation method of the compound traditional Chinese medicine and the application of the compound traditional Chinese medicine in the preparation of antiviral medicines.

Description

A kind of antiviral animal compound Chinese medicine and its production and use
Technical field
The present invention relates to a kind of antiviral animal compound Chinese medicine and its production and use, belong to field of veterinary.
Background technology
Avian viruses class disease is propped up by newcastle, mild bird flu, kidney biography, passed the viral a kind of high degree in contact sexually transmitted disease caused such as larynx, infectious bursal disease, fowlpox, is the one of the main reasons affecting aviculture sound development and birds product safety.The clinical manifestation of this class disease is ill chicken dyspnea, dysentery, serous coat and mucosa hemorrhage, and inappetence, reduction of searching for food, losing weight even occurs death, and the case that the course of disease is slightly grown is often with nervous symptoms.Because Abwehrkraft des Koepers declines after chicken group infects virus, usually there is the bacteriological infection such as Secondary cases escherichia coli, staphylococcus aureus, Bacillus typhi, dysentery bacterium, streptococcus, trouble fowl case fatality rate is increased suddenly, has a strong impact on the fertility performance of cultivation.
In the cultivation of fowl industry, the main means of prevention for highly infective virosis comprises vaccine immunity, Antybody therapy, the treatment of antiviral chemical medicine and treatment by Chinese herbs.But in order to prevent people and animals' cross infection, the Ministry of Agriculture has stopped the examination & approval of the antiviral chemicalses such as ribavirin, amantadine and Moroxydine, and forbids using in livestock and poultry cultivation.Therefore, the prevention and control of current virosis mainly rely on sets up and performs every prevention system and immunity inoculation work to reduce the risk of falling ill of cultivated animals, namely puts prevention first, holds concurrently and heavily treat.
Because virus variation is fast, new virus type constantly increases, and the research and development of vaccine are relatively slow and delayed, and thus existing vaccine often can not effective Control and prevention virosis.In addition, the impact of the factors such as often have in actual breeding production that low, the wild poison (comprising virulent) of maternal antibody is polluted, vaccine quality is inconsistent and interference between vaccine, immunosuppressant, immune programme for children be unreasonable, the effect of vaccine immunity is weakened greatly, and often cause immuning failure, so this class disease often presents atypia disease symptom in vaccinated flock, have long, morbidity incubation period suddenly, mortality rate high.Therefore, avian viruses class disease still remains high at the sickness rate of China, prevents and can not stop.
Modern Chinese medicine pharmaceutical research is thought: many Chinese herbal medicine have antibacterial, antiinflammatory, antipyretic, the effect such as antiviral, adjustment immunity of organisms, and have that toxic and side effects is little, noresidue, have no drug resistance, the advantage such as multicomponent Synergistic.Thus the research of natural drug more and more comes into one's own, and becomes the hot fields in antiviral direction gradually.
In herbal mixture of the present invention, Radix Aconiti Lateralis Preparata has recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, drives effect of damp by wind and cold, and its extract component has heart tonifying, shock, antiinflammatory, analgesic effect, can improve body tolerance, enhancing human body immunity regulating power; Radix Scrophulariae has clearing away heat and cooling blood, removing toxic substances, eliminating stagnation sore-throat relieving, effect of YIN nourishing.Two medicines phases 5, cold and heat are double to be controlled, and supplements and complements each other, therefore is monarch drug altogether.
Rhizoma Acori Graminei fragrance and faling apart, wards off foul, happy hole, sharp nine orifices, helps Radix Aconiti Lateralis Preparata to have one's ideas straightened out recuperating depleted YANG, refreshment sedate; Radix Paeoniae Rubra, Herba Taraxaci, Herba Lycopi help Radix Scrophulariae to strengthen the effect of removing pathogenic heat from blood and toxic substance from the body, more can promoting blood circulation to remove blood stasis, and inducing diuresis to remove edema, alleviates and organize congestion and edema symptom.The auxiliary monarch of above two medicine is minister.
Radix Rubiae cooling blood for hemostasis , Rhizoma Dioscoreae Septemlobae dampness removing row turbid, the two take into account hemostasis, detoxicating effect and be adjuvant drug.
Radix Glycyrrhizae and other each medicines, anti-bias and can to detoxify and for making medicine.
Summary of the invention
An object of the present invention is to provide a kind of antiviral animal compound Chinese medicine, the each ingredient of this herbal mixture can synergism after reasonable formula, instant effect, curative effect is strong, immunity of poultry can be strengthened, improve antiviral ability, atypical newcastle disease, newcastle, mild bird flu, kidney are passed, to pass the virosis such as larynx, infectious bursal disease, fowlpox all effective in cure.
Two of object of the present invention is to provide the herbal mixture concentrated extract be made up of this herbal mixture.
Three of object of the present invention is to provide the preparation method of the herbal mixture concentrated extract be made up of this herbal mixture.
Four of object of the present invention is to provide the compound preparation be made up of this herbal mixture or herbal mixture concentrated extract, comprises oral liquid, granule, powder, pre-mixing agent.
Five of object of the present invention is to provide the preparation method of above-mentioned compound preparation.
The object of the invention is to be realized by following technological means:
The invention provides a kind of antiviral animal compound Chinese medicine and preparation method thereof, it is characterized in that being made up of following weight portion Chinese medicine: Radix Aconiti Lateralis Preparata 1.5-9, Radix Scrophulariae 1.5-20, Rhizoma Acori Graminei 1.5-30, Radix Paeoniae Rubra 1.5-20, Herba Taraxaci 1-30, Herba Lycopi 1-30, Radix Rubiae 1-30, Rhizoma Dioscoreae Septemlobae 1-30, Radix Glycyrrhizae 1-30.
Preferably this compound recipe is made up of following weight portion Chinese medicine: Radix Aconiti Lateralis Preparata 3-5, Radix Scrophulariae 6-12, Rhizoma Acori Graminei 10-25, Radix Paeoniae Rubra 6-12, Herba Taraxaci 10-25, Herba Lycopi 5-25, Radix Rubiae 5-25, Rhizoma Dioscoreae Septemlobae 10-20, Radix Glycyrrhizae 10-20.
Further preferably this compound recipe is made up of following weight portion Chinese medicine: Radix Aconiti Lateralis Preparata 3, Radix Scrophulariae 8, Rhizoma Acori Graminei 20, Radix Paeoniae Rubra 12, Herba Taraxaci 24, Herba Lycopi 16, Radix Rubiae 20, Rhizoma Dioscoreae Septemlobae 16, Radix Glycyrrhizae 15.
Herbal mixture of the present invention adds pharmaceutically acceptable adjuvant, can make clinical or pharmaceutically acceptable dosage form.
Wherein, clinical and pharmaceutically acceptable dosage form be oral liquid, granule, powder.
In described oral liquid, concentrated extract accounts for the 30%-85% of gross mass, and optimum amount is 65%.
In described granule, concentrated extract (before oven dry) consumption is 25%-65%, and optimum amount is 40%.
In described powder, herbal mixture consumption is 60%-100%, and optimum amount is 90%.
Present invention also offers the herbal mixture pre-mixing agent be made up of above-mentioned herbal mixture.
The constituent of described herbal mixture pre-mixing agent comprises: Radix Aconiti Lateralis Preparata, Radix Scrophulariae, Rhizoma Acori Graminei, Radix Paeoniae Rubra, Herba Taraxaci, Herba Lycopi, Radix Rubiae, Rhizoma Dioscoreae Septemlobae, Radix Glycyrrhizae, vitamin A, vitamin D3, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, calcium pantothenate, nicotiamide, folic acid, biotin, copper sulfate, ferrous sulfate, zinc sulfate, manganese sulfate, sodium selenite and adjuvant.
The feature of described herbal mixture pre-mixing agent is: containing Radix Aconiti Lateralis Preparata 30-40g in every 1kg pre-mixing agent, Radix Scrophulariae 60-90g, Rhizoma Acori Graminei 100-130g, Radix Paeoniae Rubra 60-90g, Herba Taraxaci 100-120g, Herba Lycopi 60-90g, Radix Rubiae 50-80g, Rhizoma Dioscoreae Septemlobae 100-130g, Radix Glycyrrhizae 90-120g, vitamin A 2,000,000 IU-300 ten thousand IU, vitamin D3 500,000 IU-100 ten thousand IU, vitamin E 10-20g, vitamin K3 3-5g, vitamin B1 3-5g, vitamin B2 3-5g, vitamin B6 5-10g, vitamin B12 0.05-0.1g, vitamin C 12-20g, calcium pantothenate 12-24g, nicotiamide 20-40g, folic acid 1-2g, biotin 0.4-0.8g, copper sulfate 20-25g, ferrous sulfate 10-15g, zinc sulfate 18-30g, manganese sulfate 10-15g, sodium selenite 0.01-0.05g surplus is adjuvant.
Wherein, the adjuvant of described herbal mixture pre-mixing agent can be one or more in sucrose, glucose, corn cob, Zein powder and stone powder.
The preparation method of described herbal mixture concentrated extract is:
(1) get Radix Aconiti Lateralis Preparata, Radix Scrophulariae, Radix Paeoniae Rubra, Radix Rubiae, Radix Glycyrrhizae, chopped, add 8 times to the water of medical material, decoct 1.5 hours, by filtrate collection to drum, add water in medicine residue and again decoct 1.5 hours, collect filtrate;
(2) in the medicinal residues in (1), add Herba Taraxaci, Rhizoma Acori Graminei, Herba Lycopi, Rhizoma Dioscoreae Septemlobae, decoct with water 1.5 hours, collect filtrate, merge in decocting liquid to bucket of three times;
(3) concentrated (2) gained filtrate to room temperature lower density is the Chinese medicine fluid extract of 1.08-1.11;
(4) in fluid extract, add ethanol, limit edged stirs, and makes alcohol content reach 65-75%, and cold preservation leaves standstill 24 hours;
(5) medicinal liquid after filtering and standing, collects filtrate, filtrate recycling ethanol is equivalent to crude drug in whole 1.0g to every 1 milliliter of extractum.
The preparation method of described herbal mixture oral liquid is:
(1) get concentrated extract, add appropriate amount of auxiliary materials, stir;
(2) use purified water standardize solution, stir and get final product.
Wherein, adjuvant can be ethanol, propylene glycol, Polyethylene Glycol, glycerol, glycerin methylal, syrup one or more, preferred alcohol, syrup.
The preparation method of described herbal mixture granule is:
(1) get concentrated extract, dry under 50-80 DEG C of condition, pulverize, obtain extract powder;
(2) suitable amount of sucrose is added and mix homogeneously;
(3) in (2), appropriate 65-85%(v/v is added) ethanol, prepare soft material, and cross 10 mesh sieve wet granulars;
(4) wet grain drying, granulate, subpackage, to obtain final product.
The preparation method of described herbal mixture powder is:
(1) get recipe quantity Radix Aconiti Lateralis Preparata, Radix Scrophulariae, Rhizoma Acori Graminei, Radix Paeoniae Rubra, Radix Rubiae, Herba Taraxaci, Herba Lycopi, Rhizoma Dioscoreae Septemlobae, Radix Glycyrrhizae, carry out drying, pulverizing respectively, cross 40 mesh sieve screenings;
(2) by (1) gained Chinese medicine powder mixing mixing;
(3) in (2), add suitable adjuvant mix homogeneously, to obtain final product.
Wherein, described adjuvant can be one or more in sucrose, glucose, corn cob, Zein powder and stone powder.
The preparation method of described herbal mixture pre-mixing agent is:
(1) get recipe quantity Aconitum carmichaeli, Radix Scrophulariae, Rhizoma Acori Graminei, Radix Paeoniae Rubra, Radix Rubiae, Herba Taraxaci, Herba Lycopi, Rhizoma Dioscoreae Septemlobae, Radix Glycyrrhizae, pulverize respectively, cross 40 mesh sieve screenings, for subsequent use;
(2) get recipe quantity vitamin: vitamin A, vitamin D3, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, calcium pantothenate, nicotiamide, folic acid, vitamin B12, biotin, cross 40 mesh sieve screenings respectively, for subsequent use;
(3) get recipe quantity trace element: copper sulfate, zinc sulfate, manganese sulfate, sodium selenite, cross 40 mesh sieve screenings respectively, for subsequent use;
(4) adjuvant sucrose, glucose, corn cob, Zein powder, stone powder carried out respectively drying, pulverizing, cross 40 mesh sieve screenings, for subsequent use;
(5) (1), (2), (3) are mixed 15-20 minute with (4), to obtain final product.
Described Chinese traditional compound medicine is oral preparations, and wherein oral liquid, granule mixed feeding also can mix drink, and powder and pre-mixing agent are mainly applicable to mixed feeding and use.The usage and dosage of herbal mixture of the present invention is, the every kg body weight 0.5-2.0ml of oral liquid every chicken, concentrates administration, is used in conjunction 4-6 days, preferably every kg body weight 1.0ml; The every kg body weight 0.8-3.0g of granule, is used in conjunction 4-6 days, preferably every kg body weight 1.2g; The every kg body weight 0.5-2.0g of powder, is used in conjunction 4-6 days, preferably every kg body weight 1.0g; The every kg body weight 0.3-1.0g of pre-mixing agent, is used in conjunction 5-7 days, preferably every kg body weight 0.5g.
Described Chinese traditional compound medicine is applicable to chicken atypical newcastle disease, newcastle, mild bird flu, kidney pass, pass the prevention and therapy of the virosiss such as larynx, infectious bursal disease, fowlpox.
Wherein, the prevention and therapy of atypical newcastle disease is specially adapted to.
The present invention has following features:
(1) simultaneously using both cold and hot drugs, supplements and complements each other;
(2) removing heat from blood and same use of invigorating blood circulation, make removing heat from blood not stay the stasis of blood, invigorate blood circulation and just do not hinder;
(3) removing toxic substances is lifted altogether with toxin expelling, interior can pass clearly in poison, give again evil in outlet outward.Each performs its own functions for all medicines, mutually works in coordination with, and plays recuperating depleted YANG altogether and allay excitement, removing pathogenic heat from blood and toxic substance from the body, the merit that dampness removing row is turbid;
(4) clinical practice proves that the onset of this medicine is quick, determined curative effect, persistent, from Chinese veterinarian's angle for control viral diseases opens new way;
(5) the present invention is herbal mixture, and reasonable recipe, preparation are simple, extensive, with low cost, determined curative effect of drawing materials;
(6) have nutrition and medicinal double effects concurrently, toxic and side effects is little, and Environmental compatibility is good, effectively can suppress kill virus, can regulate immunity of organism again, enables cultivation fowl better resist viral diseases;
(7) compared with chemical medicine, Chinese medicine does not remain, and does not thus have the off-drug period and abandons the egg phase;
(8) the present invention is herbal mixture, can improve immunity of organism, and fast quick-recovery body function, therefore can not affect normal immune programme for children.
Detailed description of the invention
By more specific description the present invention by embodiment below, it should be understood that described embodiment is only in order to the present invention is described, instead of limit the scope of the invention in any form.
The formula of antiviral compound traditional Chinese medicament and the preparation of concentrated extract thereof in embodiment 1 the present invention
Formula: Radix Aconiti Lateralis Preparata 6 kg, Radix Scrophulariae 12 kg, Rhizoma Acori Graminei 20 kg, Radix Paeoniae Rubra 12 kg, Herba Taraxaci 20 kg, Herba Lycopi 10 kg, Radix Rubiae 10 kg, Rhizoma Dioscoreae Septemlobae 20 kg, Radix Glycyrrhizae 20 kg.
Preparation method:
(1) get Radix Aconiti Lateralis Preparata, Radix Scrophulariae, Radix Paeoniae Rubra, Radix Rubiae, Radix Glycyrrhizae, chopped, add 8 times to the water of medical material, decoct 1.5 hours, by filtrate collection to drum, add water in medicine residue, again decoct 1.5 hours, collect filtrate to drum;
(2) in the medicinal residues in (1), add Herba Taraxaci, Rhizoma Acori Graminei, Herba Lycopi, Rhizoma Dioscoreae Septemlobae, decoct with water 1.5 hours, collect filtrate to the drum in (1);
(3) concentrated (2) gained filtrate to room temperature lower density is the Chinese medicine fluid extract of 1.08-1.11;
(4) in fluid extract, add ethanol, limit edged stirs, and makes alcohol content reach 65-75%, and cold preservation leaves standstill 24 hours;
(5) medicinal liquid after filtering and standing, collects filtrate, filtrate recycling ethanol is equivalent to crude drug in whole 1.0g to every 1 milliliter of extractum.
The formula of antiviral compound traditional Chinese medicament and the preparation of concentrated extract thereof in embodiment 2 the present invention
Formula: Radix Aconiti Lateralis Preparata 6 kg, Radix Scrophulariae 16 kg, Rhizoma Acori Graminei 40 kg, Radix Paeoniae Rubra 24 kg, Herba Taraxaci 48 kg, Herba Lycopi 32 kg, Radix Rubiae 40 kg, Rhizoma Dioscoreae Septemlobae 32 kg, Radix Glycyrrhizae 30 kg.
Preparation method: with embodiment 1.
The formula of antiviral compound traditional Chinese medicament and the preparation of concentrated extract thereof in embodiment 3 the present invention
Formula: Radix Aconiti Lateralis Preparata 10 kg, Radix Scrophulariae 24 kg, Rhizoma Acori Graminei 50 kg, Radix Paeoniae Rubra 24 kg, Herba Taraxaci 50 kg, Herba Lycopi 50 kg, Radix Rubiae 50 kg, Rhizoma Dioscoreae Septemlobae 40 kg, Radix Glycyrrhizae 40 kg.
Preparation method: with embodiment 1.
The preparation of herbal mixture oral liquid in embodiment 4 the present invention
Raw material forms: embodiment 2 concentrated extract 65kg, ethanol 15kg, propylene glycol 10kg, purified water add to 100kg.
Preparation method:
(1) in Example 1, concentrated extract adds purified water 5 kg and stirs and make it in suspension;
(2) add the propylene glycol of recipe quantity, ethanol, stir and make it to dissolve completely;
(3) with 5% sodium carbonate liquor adjust pH 4.0-6.0;
(4) purified water is added to full dose;
(5) filter, embedding, sterilizing, packaging, to obtain final product.
The preparation of herbal mixture granule in embodiment 5 the present invention
Raw material forms: embodiment 3 concentrated extract 40kg, sucrose 60kg.
Preparation method:
(1) concentrated extract in Example 1, dries under 60 DEG C of conditions, pulverizes, obtains extract powder;
(2) recipe quantity sucrose is added and mix homogeneously;
(3) in (2), appropriate 70%(v/v is added) ethanol, prepare soft material, and cross 10 mesh sieve wet granulars;
(4) wet grain drying, granulate, subpackage, to obtain final product.
The preparation of herbal mixture powder in embodiment 6 the present invention
Formula: Radix Aconiti Lateralis Preparata 6kg, Radix Scrophulariae 12kg, Rhizoma Acori Graminei 25kg, Radix Paeoniae Rubra 12kg, Herba Taraxaci 25kg, Herba Lycopi 25kg, Radix Rubiae 25kg, Rhizoma Dioscoreae Septemlobae 20kg, Radix Glycyrrhizae 20kg.
Preparation method:
(1) above-mentioned Chinese crude drug was pulverized 40 mesh sieves, by recipe quantity mixing, for subsequent use;
(2) add maize cob meal to 200kg, mix homogeneously, to obtain final product.
Herbal mixture pre-mixing agent formula and preparation method thereof in embodiment 7 the present invention
Formula: Radix Aconiti Lateralis Preparata 35 kg, Radix Scrophulariae 70 kg, Rhizoma Acori Graminei 110 kg, Radix Paeoniae Rubra 70 kg, Herba Taraxaci 110 kg, Herba Lycopi 70 kg, Radix Rubiae 60 kg, Rhizoma Dioscoreae Septemlobae 120 kg, Radix Glycyrrhizae 110 kg, vitamin A (500,000 IU/ gram) 6 kg, vitamin D3 (500,000 IU/ gram) 1.5 kg, vitamin E 15 kg, vitamin K3 5 kg, vitamin B1 5 kg, vitamin B2 5 kg, vitamin B6 8 kg, vitamin B12 0.05 kg, vitamin C 15 kg, calcium pantothenate 15 kg, nicotiamide 30 kg, folic acid 1 kg, biotin 0.4 kg, copper sulfate 20 kg, ferrous sulfate 10 kg, zinc sulfate 25 kg, manganese sulfate 12 kg, sodium selenite 0.01 kg, adjuvant adds to 1000 kg.
Preparation method:
(1) get recipe quantity Aconitum carmichaeli, Radix Scrophulariae, Rhizoma Acori Graminei, Radix Paeoniae Rubra, Herba Taraxaci, Herba Lycopi, Radix Rubiae, Rhizoma Dioscoreae Septemlobae, Radix Glycyrrhizae, crush and screen respectively, for subsequent use;
(2) recipe quantity vitamin is got: vitamin A, vitamin D3, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, calcium pantothenate, nicotiamide, folic acid, vitamin B12, biotin, crush and screen respectively, for subsequent use;
(3) recipe quantity trace element is got: copper sulfate, zinc sulfate, manganese sulfate, sodium selenite, crush and screen respectively, for subsequent use;
(4) adjuvant sucrose, corn cob carried out respectively drying, pulverizing, cross 40 mesh sieve screenings, for subsequent use;
(5) (1), (2), (3) are mixed together 20 minutes with (4), obtain final product.
Test example 1 herbal mixture of the present invention is to the contrast therapy effect test of the atypical newcastle of laying hen
1. materials and methods
1.1 trial drugs (1) embodiment of the present invention 4 herbal mixture oral liquid.(2) ribavirin oral solution, Shanghai Hefeng Pharmaceutical Co., Ltd..
1.2 Weifang, experimental animal Shandong chicken houses, there is cough in blue brown commodity egg 2000 plumage in sea, ataxia phenomenon is serious from 175 ages in days, and night, snore was comparatively large, and laying rate reduces, and the sick chicken spirit of minority is depressed, loss of appetite, row's yellow-white or Ovum Gallus domesticus album sample loose stool.Cut open inspection and see that tracheal strips has sticky discharge, annulus trachealis is congested, hemorrhage, nasal cavity has a large amount of nose liquid, and cecal tonsil swelling is obviously hemorrhage, rectum has a large amount of tip-like petechia, cloaca is hemorrhage, ovarian hemorrhage, necrosis, and follicle easily breaks, the sick Ovum Gallus domesticus of part in utero still has egg to exist, at the beginning of clinical symptoms and dissection symptom, be diagnosed as atypical newcastle disease.
1.3 test methods choose 177 age in days laying hen 500 plumages, are divided into 5 groups at random.Blank group does not do any treatment, normal water feeding; Positive controls gives ribavirin oral solution, and dosage is every kg body weight 5mg, continuous drip 5 days; Administration group gives embodiment 4 oral liquid, and is divided into three groups according to dosage, is respectively low dose group (0.5ml/kg body weight), middle dosage group (1.0ml/kg body weight) and high dose group (1.5ml/kg body weight), continuous drinking water administration 5 days.
1.4 curative effect judging standards are cured: the sick chicken of treatments period returns to one's perfect health, and spirit, appetite, body temperature etc. recover normal.Effective: treatments period symptom obviously alleviates, fully recovering or not fully recovering all is considered as effectively.
2. result of the test
As seen from table, herbal mixture basic, normal, high dosage group cure rate is respectively 81%, 93%, 93%, middle high dose group cure rate and effective percentage higher, and compare there was no significant difference with positive controls.Treat positive controls laying hen feed intake average every day every and average egg production after 5 days and all recover normal value, herbal mixture basic, normal, high dosage group laying hen feed intake average every day every is apparently higher than positive controls, wherein middle and high dosage group average egg production improves more than 35% than before treatment, improves more than 24% than positive controls.
Experimental result shows, (1) herbal mixture of the present invention infects atypical newcastle to laying hen and has good therapeutical effect, and with middle and high dosage group best results, cure rate can reach 93%; (2) herbal mixture of the present invention can significantly improve laying hen feed intake and laying rate, promotes body recovery, has the double effects improving immunity and anti-virus ability.
Test example 2 herbal mixture of the present invention is to the contrast therapy effect test of the atypical newcastle of broiler
1. materials and methods
1.1 trial drugs (1) embodiment of the present invention 4 herbal mixture oral liquid.(2) ribavirin oral solution, Shanghai Hefeng Pharmaceutical Co., Ltd..
1.2 Weifang, experimental animal Shandong chicken houses, Ross 308 Broiler 2500 plumage, 35 age in days jumpbogroups occur that feed intake declines; Rale, cough, the dyspnea symptom such as to stridulate; Have loose bowels, feces is many in yellow green, part watery diarrhea; There is fragmentary dead and residual weak chicken in chicken group; Crop is spoken in a low voice soft expansion, has liquid to flow out (crop hydrops, pneumatosis) when chicken holds.Ulcer in the middle part of duodenum nearly intestinal end, hemorrhage is shown in dissection; Near yolk stalk, the visible obvious tumefaction in aggregate nodules place such as ileum, Semen Jujubae shape ulcer and hemorrhage; Caecum, tonsil swelling are hemorrhage; Rectum vertical line shape is hemorrhage; Heart hat fat, larynx have petechia; Tracheorrhagia is aubergine.Through clinical symptoms with to dissect symptom tentative diagnosis be atypical newcastle disease.
1.3 test methods choose 35 age in days laying hen 500 plumages, are divided into 5 groups at random.Blank group does not do any treatment, normal water; Positive controls gives ribavirin oral solution, and dosage is every kg body weight 5mg, and drip administration every day secondary, first uses three, uses three again (sharing medicine six days) after observation; Administration group gives embodiment 4 oral liquid, and be divided into three groups according to dosage, be respectively low dose group (0.5ml/kg body weight), middle dosage group (1.0ml/kg body weight) and high dose group (1.5ml/kg body weight), every day drinking water administration secondary, first use three, use three after observation again (sharing medicine six days).
1.4 curative effect judging standards are cured: the sick chicken of treatments period returns to one's perfect health, and spirit, appetite, body temperature etc. recover normal.Effective: treatments period symptom obviously alleviates, fully recovering or not fully recovering all is considered as effectively.
2. result of the test
As seen from table, herbal mixture basic, normal, high dosage group cure rate is respectively 91%, 98%, 97%, middle dosage group and high dose group cure rate and effective percentage higher, and compare there was no significant difference with positive controls, treat chicken group after 3 days and stop death, within 6 days, recover normal afterwards.With positive controls ratio, middle dosage and high dose administration group broiler feed intake and weightening finish significantly improve, and feedstuff-meat ratio reduces.
Experimental result shows, herbal mixture of the present invention infects atypical newcastle to broiler and has good therapeutical effect, and can significantly improve feed intake and weightening finish, lowers feedstuff-meat ratio, improves price of deed rate.

Claims (5)

1. an antiviral animal compound Chinese medicine, is characterized in that being made up of following weight portion Chinese medicine: Radix Aconiti Lateralis Preparata 1.5-9, Radix Scrophulariae 1.5-20, Rhizoma Acori Graminei 1.5-30, Radix Paeoniae Rubra 1.5-20, Herba Taraxaci 1-30, Herba Lycopi 1-30, Radix Rubiae 1-30, Rhizoma Dioscoreae Septemlobae 1-30, Radix Glycyrrhizae 1-30.
2. herbal mixture according to claim 1, is characterized in that being made up of following weight portion Chinese medicine: Radix Aconiti Lateralis Preparata 3-5, Radix Scrophulariae 6-12, Rhizoma Acori Graminei 10-25, Radix Paeoniae Rubra 6-12, Herba Taraxaci 10-25, Herba Lycopi 5-25, Radix Rubiae 5-25, Rhizoma Dioscoreae Septemlobae 10-20, Radix Glycyrrhizae 10-20.
3. herbal mixture according to claim 1, its optimum proportioning is: Radix Aconiti Lateralis Preparata 3, Radix Scrophulariae 8, Radix Paeoniae Rubra 12, Herba Taraxaci 24, Rhizoma Acori Graminei 20, Radix Rubiae 20, Herba Lycopi 16, Rhizoma Dioscoreae Septemlobae 16, Radix Glycyrrhizae 15.
4. an antiviral animal compound Chinese medicine preparation, it is characterized in that it is made up of herbal mixture described in any one of claim 1-3, described preparation is concentrated extract, oral liquid, granule, powder or pre-mixing agent.
5. the herbal mixture described in any one of claim 1-3 is for the preparation for the treatment of or preventing the application in the medicine of atypical newcastle disease.
CN201310345654.3A 2013-08-09 2013-08-09 Antiviral compound traditional Chinese medicine for animals, and preparation method and use thereof Active CN103393891B (en)

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