CN106071090A - A kind of anti-diarrhea Chinese medicine compound feed additive and preparation method and application - Google Patents
A kind of anti-diarrhea Chinese medicine compound feed additive and preparation method and application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a kind of anti-diarrhea Chinese medicine compound feed additive, including Fructus Crataegi, Fructus Setariae Germinatus, Fructus Mume, Radix Isatidis, Flos Lonicerae, Rhizoma Coptidis, the Radix Pulsatillae, Folium Isatidis.Its preparation method: 1) configuration raw material；2) sterilization；3) High Temperature High Pressure extraction, prepares extract；4) ethanol elution, obtains alcohol eluen mixing；5) concentrate, be spray-dried；6) lyophilization, preserves, to obtain final product.During use, employing maltodextrin is carrier, is configured to the pre-mixing agent that mass fraction is 30%, is admixed feedstuff, carry out Long-term Feeding.The feed additives of the present invention protected effect grown with promotion of digestive system to domestic poultry；Prevent all kinds of diarrhoea, promote that domestic poultry grows, improve regularity and the survival rate of domestic poultry；There are balanced action, selectivity to kill antibacterial, unrestraint profitable strain to intestinal microbial population；For pure compound Chinese medicinal preparation, having no side effect and drug resistance, the food safety for meat provides good guarantee.
Description
Technical field
The present invention relates to poultry field of feed additive technology, specifically refer to a kind of anti-diarrhea Chinese medicine compound feedstuff and add
Add agent and preparation method and application.
Background technology
Domestic poultry has problems due to breeding environment and cultural technique in breeding process, causes birds in growth course
In often occur suffer from diarrhoea (dysentery).Diarrhoea (dysentery) is the symptomes complice that digestive tract function is disorderly, is frequently not finger one
Kind of self-existent disease, it had both been probably and had been caused by independent a kind of disease, it is also possible to by multiple virulence factor, (these are sick
Because of the most simultaneously or sequentially effect) cause, or a symptom adjoint during other disease.These diseases are to domestic poultry
Healthy growth causes and has a strong impact on, if disease is prevented and treated birds and the big model of domestic animal not in time that easily cause cultivation
Enclose the phenomenon of death.
Such as, the cultivation of piglet, piglet accounts for the 39.8% of piglet death sum because of diarrhoea death.In recent years, China piglet
Suffer from diarrhoea the most universal, it was reported that the piglet of below 30kg, average of the whole year sickness rate 46.5%, mortality rate 10.3%.Piglet diarrhea
The piglet survival ratio caused is low, poor growth is subject matter present in current China piglet produces, and causes piglet diarrhea
Factor is comprehensive.Piglet diarrhea ranks first in pig industry endangers, and the sound development of pig industry in serious threat, causes raising
Rate of returns is relatively low for material, piglet survival ratio declines, poor growth, growth promoter stagnate (cad pig), even death.There is no at present effectively
Vaccine, medicine solve this problem, always be grave danger of pig industry.
Existing anti-diarrhea method, is all to add anti-diarrhea antibiotic in feedstuff (such as: colistine sulfate, bacillus
Peptide zinc, chlortetracycline etc.) and heavy dose of use zinc oxide.But, although use antibiotic can be by suppression escherichia coli etc.
Harmful bacteria controls diarrhoea, but also inhibits the breeding of probiotics simultaneously, and antibiotic is as treatment medicine simultaneously, makes for a long time
Prevention and control medicine.If as prevention and control medicine life-time service, domestic poultry can be produced bigger side effect, and in the future
, also can there is bigger potential safety hazard in the food that the domestic poultry grown up by these is made, therefore, government regulator has been opened
Begin to be limited in domestic poultry on a large scale and prevent and treat aspect life-time service antibiotic.Heavy dose of use zinc oxide, can cause domestic poultry
Intestinal internal organs by expendable injury, health and survival rate to domestic poultry have tremendous influence, for raiser,
There is great economic hidden danger.
Summary of the invention
It is an object of the invention to provide one and do not contain antibiotic and zinc oxide, and it is dirty to improve domestic poultry intestinal
The anti-diarrhea Chinese medicine compound feed additive of device environment.
Further object is that the concrete preparation method that this anti-diarrhea Chinese medicine compound feed additive is provided.
A further object of the invention is in the specifically side of application providing this anti-diarrhea Chinese medicine compound feed additive
Method.
The domestic poultry being suitable for of the present invention includes: various meat producing animal, including chicken, duck, pig, cattle, sheep.
The present invention is suitable for each growth stage of above-mentioned domestic poultry, uses the stage including the stage of brooding, growth stage, kind.
The present invention is achieved through the following technical solutions: a kind of anti-diarrhea Chinese medicine compound feed additive, including Fructus Crataegi, paddy
Bud, Fructus Mume, Radix Isatidis, Flos Lonicerae, Rhizoma Coptidis, the Radix Pulsatillae, Folium Isatidis.
Diarrhoea causes the lethal reason of domestic poultry to be, due to virus, antibacterial or the abdomen caused by overnutrition
Rushing down, the intestinal villus of major determinant digestive system, cause domestic poultry to reduce the ability of alimentation, serious meeting causes domestic
The dehydration of poultry body, malnutrition and dead, even if survival, all can because of intestinal villus impaired development, alimentation ability drop
Low, cause animal that the absorbability of nutrition is died down, dysplasia.
The medicine principle using antibiotic to prevent and treat domestic poultry diarrhoea is that antibiotic is the harmful bacteria by killing intestinal,
Such as escherichia coli, Salmonella etc. control diarrhoea, but while killing these harmful bacterias, have also killed probiotics, children
Toy uses antibiotic too early, the most serious to the hepar damnification of brood.
The medicine principle adding zinc oxide preventing and treating domestic poultry diarrhoea in feedstuff is, is to increase by one layer of physical property to intestinal
The protection of energy, is equivalent to plate last layer secluding film at intestinal tract surface, stops the intrusion of antibacterial, but its side effect also hinders simultaneously
Hinder the growth of intestinal villus, also reduce the intestinal villus absorption to nutrition simultaneously,
The mechanism of action of Chinese medicine compound mixture of the present invention is, quickly the cleaning curdled milk of domestic poultry gastric, holding
Domestic poultry gastrointestinal is unobstructed, and quickly repairs intestinal mucosa, intercepts secondary infection, promotes that villose growth is repaired,
By suppression virus breeding, strengthen domestic poultry autoimmune ability, thus realize the rapid healing that domestic poultry is suffered from diarrhoea.
The herbal pharmacology of the most each component is:
Fructus Crataegi: nature and flavor are sour, sweet, tepor.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery suffers from abdominal pain,
Blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain；Hyperlipemia.Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving effect strengthens.For meat
Stagnant, dysentery is not well.
Fructus Setariae Germinatus: nature and flavor are sweet, temperature.Help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, the most hungry
Lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for the most hungry lack of appetite.Fructus Setariae Germinatus (parched to brown) kindization stagnates, and does not disappears for stagnant.
Fructus Mume: nature and flavor are sour, puckery is flat.Astringe the lung, astringing intestine to stop diarrhea, promote the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat quenches one's thirst,
Ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.
Radix Isatidis: nature and flavor are bitter, cold.Heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, and sore throat is rotten
Larynx scarlet fever, major part pestilence, erysipelas, carbuncle.
Flos Lonicerae: nature and flavor are sweet, cold.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, wind
Hotness emits, and epidemic febrile disease is generated heat.
Rhizoma Coptidis: cold in nature, bitter in the mouth.Heat clearing and damp drying, eliminating fire and detoxication.Belong to the heat clearing and dampness removing medicine of antipyretic subordinate classification.
The Radix Pulsatillae: nature and flavor are bitter, cold.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.
Folium Isatidis: nature and flavor are bitter, cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, send out speckle dermexanthesis, yellow
Subcutaneous ulcer, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.
To better implement the present invention, further, including Fructus Crataegi 5-35 part, Fructus Setariae Germinatus 2-18 part, Fructus Mume 6-25 part, Baphicacanthus cusia
Root 8-25 part, Flos Lonicerae 5-18 part, Rhizoma Coptidis 5-25 part, Radix Pulsatillae 5-30 part, Folium Isatidis 3-18 part.
To better implement the present invention, further, described Chinese medicine compound feed additive also includes Herba Plantaginis, sweet
Grass, Radix Scrophulariae.
Herba Plantaginis: cold in nature, sweet in the mouth.Clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances.The diuresis belonging to damp-clearing drug subordinate classification is led to
Drench medicine.
Radix Glycyrrhizae: nature and flavor are put down, sweet.Invigorating the spleen and replenishing QI, eliminating phlegm and stopping cough, emergency analgesic therapy, the property of medicine that is in harmonious proportion.Belong to the benefit of classification under qi-restoratives medicine
Gas medicine.
Radix Scrophulariae: cold nature is sweet in the mouth, hardship, salty.Removing heat from blood YIN nourishing, eliminating fire and detoxication.Belong to the heat removing and blood cooling medicine of classification under antipyretic.
To better implement the present invention, further, Herba Plantaginis 3-18 part, Radix Glycyrrhizae 1-5 part, Radix Scrophulariae 1-5 part.
To better implement the present invention, further, this anti-diarrhea Chinese medicine compound feed additive includes following weight
The raw material of part:
Fructus Crataegi 10-15 part, Fructus Setariae Germinatus 6-12 part, Fructus Mume 8-15 part, Radix Isatidis 10-15 part, Flos Lonicerae 6-13 part, Rhizoma Coptidis 10-
15 parts, Radix Pulsatillae 10-20 part, Folium Isatidis 3-10 part, Herba Plantaginis 3-10 part, Radix Glycyrrhizae 1-2 part, Radix Scrophulariae 1-2 part.
To better implement the present invention, further, this anti-diarrhea Chinese medicine compound feed additive includes following weight
The raw material of part:
Fructus Crataegi 8 parts, Fructus Setariae Germinatus 8 parts, crow 12 parts, Radix Isatidis 12 parts, Flos Lonicerae 8 parts, Rhizoma Coptidis 12 parts, the Radix Pulsatillae 15 parts, Folium Isatidis
6 parts of leaf, Herba Plantaginis 6 parts, 1 part of Radix Glycyrrhizae, Radix Scrophulariae 1 part.
The preparation method of above-mentioned anti-diarrhea Chinese medicine compound feed additive, comprises the following steps:
(1) by weight, configuration traditional Chinese medicinal material raw materials；
(2) carry out disinfection unified for traditional Chinese medicinal material raw materials complete for configuration；
(3) traditional Chinese medicinal material raw materials sterilization completed carries out High Temperature High Pressure extraction, prepares extract；
(4) ethanol solution using 95% carries out eluting to the extract prepared in step (3), and will obtain alcohol eluen
Mixing；
(5) concentrate mixed ethanol elution further, obtain the concentrated solution that proportion is 0.6～0.8, concentrated solution is entered
Row spray drying obtains extract dry powder；
(6) lyophilization, encapsulation, it is placed in the place of being dried and preserves, to obtain final product.
In order to the preparation method of the present invention is better achieved, further, described step (2) disinfection way uses high temperature to steam
Vapour is sterilized.
In order to the preparation method of the present invention is better achieved, further, described prepared anti-diarrhea Chinese medicine compound is raised
Feed additives is powder.
The application process of above-mentioned anti-diarrhea Chinese medicine compound feed additive, uses obtained for preparation Chinese medicine compound mixture
Maltodextrin, as carrier, is configured to the pre-mixing agent that mass fraction is 30%, takes the 0.5～5kg pre-mixing agent configured and admixes
1000kg normal diet, then carries out Long-term Feeding by the feedstuff being mixed with pre-mixing agent to domestic poultry.
The present invention compared with prior art, has the following advantages and beneficial effect:
(1) present invention is applicable to various meat producing animal, and each stage grown up including chicken, duck, pig, cattle, sheep, including educating
Young, grow, plant use；
(2) present invention is not only protected to the digestive system of domestic poultry and promotes the effect grown, it is also possible to prevention is each
Viroid property, bacterial diarrhea, additionally it is possible to promote that long wool hair is educated, strengthen the intestinal absorption to nutrition, promote domestic poultry
Digestion, absorb, allow the growing that brood is more healthy；
(3) intestinal microbial population is had balanced action, selectivity to kill escherichia coli, aerogenesis shuttle by feed additives of the present invention
Bacterium, to profitable strain unrestraint, does not has any damage to liver；
(4) feed additives of the present invention is pure compound Chinese medicinal preparation, has no side effect, and has no drug resistance, for domestic domestic animal
Food safety provide good safety guarantee.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention is not limited to this,
Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, make various replacing
Change and change, all should be included within the scope of the invention.
Embodiment 1:
In the present embodiment, this anti-diarrhea Chinese medicine compound feed additive, including the raw material of following weight portion:
Fructus Crataegi 8 parts, Fructus Setariae Germinatus 8 parts, crow 12 parts, Radix Isatidis 12 parts, Flos Lonicerae 8 parts, Rhizoma Coptidis 12 parts, the Radix Pulsatillae 15 parts, Folium Isatidis
6 parts of leaf, Herba Plantaginis 6 parts, 1 part of Radix Glycyrrhizae, Radix Scrophulariae 1 part.
Concrete preparation method, comprises the following steps:
(1) by weight, configuration traditional Chinese medicinal material raw materials；
(2) high-temperature steam sterilization is carried out by unified for traditional Chinese medicinal material raw materials complete for configuration；
(3) traditional Chinese medicinal material raw materials sterilization completed carries out High Temperature High Pressure extraction, prepares extract；
(4) ethanol solution using 95% carries out eluting to the extract prepared in step (3), and will obtain alcohol eluen
Mixing；
(5) concentrate mixed ethanol elution further, obtain the concentrated solution that proportion is 0.6～0.8, concentrated solution is entered
Row spray drying obtains extract dry powder；
(6) lyophilization, encapsulation, it is placed in the place of being dried and preserves, obtain the powder of this Chinese medicine compound feed additive.
Embodiment 2:
Present embodiment discloses this anti-diarrhea Chinese medicine compound feed additive, including following raw material, by weight:
Fructus Crataegi 5 parts, Fructus Setariae Germinatus 2 parts, crow 6 parts, Radix Isatidis 8 parts, Flos Lonicerae 5 parts, Rhizoma Coptidis 5 parts, the Radix Pulsatillae 5 parts, Folium Isatidis 3
Part, Herba Plantaginis 3 parts, 1 part of Radix Glycyrrhizae, Radix Scrophulariae 1 part.
Embodiment 3；
Present embodiment discloses this anti-diarrhea Chinese medicine compound feed additive, including following raw material, by weight:
Fructus Crataegi 35 parts, Fructus Setariae Germinatus 18 parts, Fructus Mume 25 parts, Radix Isatidis 25 parts, Flos Lonicerae 18 parts, Rhizoma Coptidis 25 parts, the Radix Pulsatillae 30 parts,
Folium Isatidis 18 parts, Herba Plantaginis 15 parts, 4 parts of Radix Glycyrrhizae, Radix Scrophulariae 4 parts.
Embodiment 4:
Present embodiment discloses this anti-diarrhea Chinese medicine compound feed additive, including following raw material, by weight:
Fructus Crataegi 15 parts, Fructus Setariae Germinatus 12 parts, Fructus Mume 15 parts, Radix Isatidis 15 parts, Flos Lonicerae 13 parts, Rhizoma Coptidis 15 parts, the Radix Pulsatillae 20 parts,
Folium Isatidis 10 parts, Herba Plantaginis 10 parts, 2 parts of Radix Glycyrrhizae, Radix Scrophulariae 2 parts.
Embodiment 5:
Present embodiment discloses this anti-diarrhea Chinese medicine compound feed additive, including following raw material, by weight:
Fructus Crataegi 10 parts, Fructus Setariae Germinatus 6 parts, Fructus Mume 8 parts, Radix Isatidis 10 parts, Flos Lonicerae 6 parts, Rhizoma Coptidis 10 parts, the Radix Pulsatillae 10 parts, big
Folium Isatidis 3 parts, Herba Plantaginis 3 parts, 1 part of Radix Glycyrrhizae, Radix Scrophulariae 1 part.
Embodiment 6:
The present embodiment provides the toxicology test of this anti-diarrhea Chinese medicine compound feed additive, specific as follows:
Acute toxicity test:
Experimental observation, because measuring LD50, therefore has carried out the mensuration of maximum dosage-feeding.Chinese medicine prepared by embodiment 1
Compound mixture is dissolved in sterile saline, is configured to solution gavage mice, and result shows, with medicine maximum administration concentration
9.65 crude drugs/ml, the maximum volume 50ml/kg that is administered were administered twice to mouse stomach in 24 hours, and mice maximum dosage-feeding is
763.25g crude drug/kg, there is not untoward reaction and death in animal, anatomic observation each internal organs no abnormality seen.
Long term toxicity test
This test application SD rat 80, Chinese medicine compound mixture embodiment 1 prepared is dissolved in sterile saline,
It is configured to solution gavage, if matched group and 24g, 35g, 49g crude drug/kg dosage group, continuous gastric infusion 12 weeks, observes the present invention
The Chinese medicine composition impact on animal indices.Result of the test shows, successive administration 12 weeks, the Chinese medicine composition of the present invention
The body weight of rat, food ration, peripheral hemogram, clotting time, electrocardiogram, organ index etc. are all had no significant effect；Blood biochemical
Ten binomial index determining results, are administered 12 weeks low dose group BiLi values higher than matched group (P < 0.05)；Low dose group, middle dosage group
TP value is higher than matched group (P < 0.05), but all within normal physiologic range, other index compares no significant difference with matched group.
Convalescent period each administration group indices measured value compares equal no significant difference with matched group.The each internal organs gross examination of skeletal muscle of each group has no different
Often.
Embodiment 6:
Present embodiment discloses the concrete application process of this anti-diarrhea Chinese medicine compound feed additive, with pig cultivation for showing
Example, uses maltodextrin as carrier in obtained for preparation Chinese medicine compound mixture, is configured to the pre-mixing agent that mass fraction is 30%,
Take the pre-mixing agent that 300g configures and admix the common pig feed of 100kg, then full group boar is entered by the pig feed being mixed with pre-mixing agent
Row is the most continual to be fed.
Carry out the boar prevented, significantly reducing of ill virus diarrhea disease, and the boar suffered from diarrhoea, discharge a large amount of curdled milk,
Sick pig body surface starts to be dried, and feces gradually starts thick, and intestinal mucosa, long fine hair are not damaging and starting to repair, and are significantly controlled
Therapeutic effect.
Selecting piglet as object of study, instantiation is as follows:
Test 1:
Daxian county, thought Xin Lianda plant, on October 2nd, 2015 to November 1, by of the present invention
Use dextrin as carrier in obtained for preparation Chinese medicine compound mixture, be diluted to the pre-mixing agent liquid that mass fraction is 30%, take 2kg
Pre-mixing agent admixes the ratio of the common pig feed of 1000kg, then by the pig feed with anti-diarrhea Chinese medicine compound feed additive
Full group pig is carried out the most continual feeding, and diarrhea rate is 0.8%.Specific experiment data are as shown in Table 1:
Table one
| Group | Test group | Matched group |
| Prevention quantity (head) | 500 | 500 |
| Diarrhoea number (head) | 4 | 32 |
| Just starting weight (kg/ head) | 11.2 | 11.3 |
| End weight (kg/ head) | 22.3 | 22.0 |
| Daily gain (head) | 0.37 | 0.36 |
| Day feed consumption (kg) | 0.65 | 0.64 |
| Feedstuff-meat ratio | 1.75 | 1.77 |
Test 2:
Daxian county, thought Xin Lianda plant, on November 12nd, 2015 to December 1 day, by of the present invention
Use dextrin as carrier in obtained for preparation Chinese medicine compound mixture, be diluted to the pre-mixing agent that mass fraction is 30%, take 2kg pre-
Mixture admixes the ratio of the common pig feed of 1000kg, then by the pig feed pair with anti-diarrhea Chinese medicine compound feed additive
Full group pig carries out the most continual feeding, and sickness rate is 0.23%.Specific experiment data are as shown in Table 2:
Table two
| Group | Test group | Matched group |
| Quantity (head) | 439 | 439 |
| Diarrhoea number (head) | 1 | 29 |
| Just starting weight (kg/ head) | 10.32 | 11.03 |
| End weight (kg/ head) | 21.2 | 22.3 |
| Daily gain (head) | 0.396 | 0.376 |
| Day feed consumption (kg) | 0.66 | 0.65 |
| Feedstuff-meat ratio | 1.67 | 1.73 |
Test 3:
Daxian county, thought Xin Lianda plant, on March 23rd, 2016 to April 22, by of the present invention
Use dextrin as carrier in obtained for preparation Chinese medicine compound mixture, be diluted to the pre-mixing agent that mass fraction is 30%, take 2000g
Pre-mixing agent admixes the ratio of the common pig feed of 1000kg, then by the pig feed with anti-diarrhea Chinese medicine compound feed additive
Full group pig is carried out the most continual feeding, after a period of time, has no swinery diarrhoea morbidity.Specific experiment data such as table three institute
Show:
Table three
| Group | Test group | Matched group |
| Quantity (head) | 325 | 325 |
| Diarrhoea number (head) | 0 | 18 |
| Just starting weight (kg/ head) | 14.32 | 14.11 |
| End weight (kg/ head) | 25.02 | 24.38 |
| Daily gain (head) | 0.357 | 0.342 |
| Day feed consumption (kg) | 0.63 | 0.65 |
| Feedstuff-meat ratio | 1.76 | 1.90 |
Being shown from table one, table two, the data of table three, the Chinese medicine compound mixture that the present invention provides is to prevention and piglet
Diarrhoea, has significant effect, is substantially reduced piglet diarrhea rate, and daily gain has the increase of little scope, and feedstuff-meat ratio decreases.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: not
Depart from and these embodiments can be carried out multiple change under the principle of the present invention and objective, revise, replace and modification, the present invention's
Scope is limited by claim and equivalent thereof.
Claims (10)
1. an anti-diarrhea Chinese medicine compound feed additive, it is characterised in that include Fructus Crataegi, Fructus Setariae Germinatus, Fructus Mume, Radix Isatidis, gold
Flos Lonicerae, Rhizoma Coptidis, the Radix Pulsatillae, Folium Isatidis.
One the most according to claim 1 anti-diarrhea Chinese medicine compound feed additive, it is characterised in that by weight
Meter, including Fructus Crataegi 5-35 part, Fructus Setariae Germinatus 2-18 part, Fructus Mume 6-25 part, Radix Isatidis 8-25 part, Flos Lonicerae 5-18 part, Rhizoma Coptidis 5-25 part,
Radix Pulsatillae 5-30 part, Folium Isatidis 3-18 part.
One the most according to claim 2 anti-diarrhea Chinese medicine compound feed additive, it is characterised in that described middle recurrence due to taking drug
Side's feed additive also includes Herba Plantaginis, Radix Glycyrrhizae, Radix Scrophulariae.
One the most according to claim 3 anti-diarrhea Chinese medicine compound feed additive, it is characterised in that Herba Plantaginis 3-18
Part, Radix Glycyrrhizae 1-5 part, Radix Scrophulariae 1-5 part.
One the most according to claim 4 anti-diarrhea Chinese medicine compound feed additive, it is characterised in that this is anti-diarrhea
Chinese medicine compound feed additive includes the raw material of following weight portion: Fructus Crataegi 10-15 part, Fructus Setariae Germinatus 6-12 part, Fructus Mume 8-15 part, Baphicacanthus cusia
Root 10-15 part, Flos Lonicerae 6-13 part, Rhizoma Coptidis 10-15 part, Radix Pulsatillae 10-20 part, Folium Isatidis 3-10 part, Herba Plantaginis 3-10 part, sweet
Grass 1-2 part, Radix Scrophulariae 1-2 part.
One the most according to claim 5 anti-diarrhea Chinese medicine compound feed additive, it is characterised in that this is anti-diarrhea
Chinese medicine compound feed additive includes the raw material of following weight portion: Fructus Crataegi 8 parts, Fructus Setariae Germinatus 8 parts, crow 12 parts, Radix Isatidis 12 parts, gold silver
Spend 8 parts, Rhizoma Coptidis 12 parts, the Radix Pulsatillae 15 parts, Folium Isatidis 6 parts, Herba Plantaginis 6 parts, 1 part of Radix Glycyrrhizae, Radix Scrophulariae 1 part.
The preparation method of the most above-mentioned anti-diarrhea Chinese medicine compound feed additive, it is characterised in that comprise the following steps:
1) by weight, configuration traditional Chinese medicinal material raw materials；
(2) carry out disinfection unified for traditional Chinese medicinal material raw materials complete for configuration；
(3) traditional Chinese medicinal material raw materials sterilization completed carries out High Temperature High Pressure extraction, prepares extract；
(4) ethanol solution using 95% carries out eluting to the extract prepared in step (3), and will obtain alcohol eluen mixing；
(5) concentrate mixed ethanol elution further, obtain the concentrated solution that proportion is 0.6 ~ 0.8, concentrated solution is sprayed
Mist is dried to obtain extract dry powder；
(6) lyophilization, encapsulation, it is placed in the place of being dried and preserves, to obtain final product.
The preparation method of anti-diarrhea Chinese medicine compound feed additive the most according to claim 7, it is characterised in that described
Step (2) disinfection way uses high-temperature steam sterilization.
9. according to the preparation method of the anti-diarrhea Chinese medicine compound feed additive described in claim 7 or 8, it is characterised in that
Described prepared anti-diarrhea Chinese medicine compound feed additive is powder.
10. the application process of anti-diarrhea Chinese medicine compound feed additive described in any one of claim 1 ~ 6, it is characterised in that
Use maltodextrin as carrier in obtained for preparation Chinese medicine compound mixture, be configured to the pre-mixing agent that mass fraction is 30%, take
The pre-mixing agent that 0.5 ~ 5kg configures admixes 1000kg normal diet, then the feedstuff being mixed with pre-mixing agent is carried out domestic poultry
Long-term Feeding.
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Application publication date: 20161109 |