CN102657794A - Traditional Chinese medicine for prevention and treatment of pullorum disease, preparation method thereof and feed - Google Patents
Traditional Chinese medicine for prevention and treatment of pullorum disease, preparation method thereof and feed Download PDFInfo
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Abstract
The invention provides traditional Chinese medicine for prevention and treatment of pullorum diseases, which comprises coptis chinensis, radix sophorae flavescentis, pulsatilla chinensis, rhizoma anemarrhenae, selfheal, honeysuckle, radix scrophulariae, codonopsis pilosula, rhizoma atractylodis macrocephalae, lotus seeds, dark plum, granatum and semen coicis. The traditional Chinese medicine has the advantages of high efficacy, fewer toxic and side effects, no residues, no resistance to drugs, no environmental pollution, capability of improving the body resistance, short treatment course, rapid effects and wide scope of promotion and application in prevention and treatment of chicken suffering from pullorum diseases.
Description
Technical field
The present invention relates to the herbal medicine technical field, relate in particular to a kind of Chinese medicine that is used to prevent and treat Pullorum Disease.
Background technology
Pullorum Disease is the big and multiple infectious disease of poultry husbandry hazardness always, and generation is all arranged all over the world, and is the highest with the chickling M & M in 10 monthly ages, therefore, once in quite long period, is considered to have only just infection morbidity of chickling.In later stage 1980's, people have had new understanding to the occurrence regularity of Pullorum Disease, and primary disease is the chickling susceptible not only, and the young chicken of 50～120 ages in days also often has and breaks out.The harm of this disease can run through the whole growth process of chicken, and fatality rate is one of infectious disease of harm maximum in the aviculture up to 50%～60%.
The cause of disease of Pullorum Disease is Pullorum Disease Salmonella (S. Pullorum) (being called for short the Hakuri bacterium, down together).Salmonella (Sallonella) pathogen belongs to enterobacteriaceae, and Salmonella is large numbers of similar gram negative bacilli of form, cultural character, reaction and antigenic structure in the humans and animals intestinal that parasitize.Salmonellosis is a kind of common important infecting both domestic animals and human intestinal tract disease, is one of zoonosis significant on the public hygienics, comprises causing alimentary toxicosis, causes the antibacterial of gastroenteritis, typhoid fever and paratyphoid fever.Pullorum Disease Salmonella form is the two ends elongated bacillus (0.3～0.5 μ m * 1～1.25 μ m) of circle slightly, and Gram-positive is not moved; No pod membrane does not form spore, amphimicrobian; Cold-resistant thermo-labile in the external environment; Dead immediately in boiling water, can kill but boil 5min in the egg domestic demand, general disinfectant can both be killed it at short notice.This bacterium is infected chicken and turkey only, and bacteria containing amount is the highest in liver, lung, intestinal, yolk sac, the heart and the blood of sick chicken.
The pathogenesis of white diarrhea disease is still not fully aware of at present.It is generally acknowledged that the Hakuri bacterium gets into body,, settle down, breed that the thalline in the macrophage is destroyed and then discharges endotoxin at intestinal wall by macrophage phagocytic.When the animal body resistance was strong, the Hakuri bacterium was eliminated through 1～5 day at enteral.In case environment is suitable, when Abwehrkraft des Koepers weakens, the Hakuri bacterium is distributed to each histoorgan with blood circulation, thereby forms corresponding pathological change and clinical symptoms.
The common method of prevention at present and treatment white diarrhea disease is to rely on Western medicine controls such as antibiotics and sulfonamides; Though obtained certain curative effect, extensive use and unreasonable use along with antibacterials have caused the Salmonella gallinarum drug resistance to increase year by year; Cause that not only pathogen produces drug resistance; Can cause that also conditionality pathogenic bacterium and parachorium bacterium produce drug resistance, and drug resistance can pass to the crowd through food chain, also endanger human health.Therefore, seek to prevent and treat the good effect and the non-harmful medicament-resistant inhibitor of salmonellosis of chicken, the poultry prod that obtains safety more and more comes into one's own.
Chinese medicine is the distinctive natural resources of China; Infect, reverse aspect such as (or inhibition) tumor cell drug resistance in treatment and shown unique effect, this points out us can in Chinese medicine, seek existing good drug-resistant and eliminates the medicine that effect does not have the lower prevention of toxic and side effects or toxic and side effects again and treats white diarrhea disease.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel being used to prevent and treat Chinese medicine of Pullorum Disease and preparation method thereof, adopt this Chinese medicine to Pullorum Disease prevention and treatment has efficiently, toxic and side effects is little, noresidue, do not develop immunity to drugs, free from environmental pollution, can increase Abwehrkraft des Koepers, short treating period, effect rapid, cheap, have and advantage such as apply.
Ask that in order to solve above-mentioned technology the invention provides the Chinese medicine of a kind of prevention and treatment Pullorum Disease, it comprises: Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Pulsatillae, the Rhizoma Anemarrhenae, Spica Prunellae, Flos Lonicerae, Radix Scrophulariae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Nelumbinis, Fructus Mume, Pericarpium Granati, Semen Coicis.
Wherein, The ratio of weight and number of each component in the said Chinese medicine is Rhizoma Coptidis 33～39 weight portions, Radix Sophorae Flavescentis 13～19 weight portions, the Radix Pulsatillae 42～49 weight portions, the Rhizoma Anemarrhenae 36～42 weight portions, Spica Prunellae 17～21 weight portions, Flos Lonicerae 23～30 weight portions, Radix Scrophulariae 12～18 weight portions, Radix Codonopsis 25～32 weight portions, the Rhizoma Atractylodis Macrocephalae 20～26 weight portions, Semen Nelumbinis 15～22 weight portions, Fructus Mume 13～18 weight portions, Pericarpium Granati 10～16 weight portions, Semen Coicis 9～14 weight portions.
Wherein, The ratio of weight and number of each component in the said Chinese medicine is Rhizoma Coptidis 36～39 weight portions, Radix Sophorae Flavescentis 16～19 weight portions, the Radix Pulsatillae 46～49 weight portions, the Rhizoma Anemarrhenae 39～42 weight portions, Spica Prunellae 19～21 weight portions, Flos Lonicerae 26～30 weight portions, Radix Scrophulariae 15～18 weight portions, Radix Codonopsis 28～32 weight portions, the Rhizoma Atractylodis Macrocephalae 23～26 weight portions, Semen Nelumbinis 19～22 weight portions, Fructus Mume 15～18 weight portions, Pericarpium Granati 13～16 weight portions, Semen Coicis 12～14 weight portions.
Wherein, said Chinese medicine can also comprise Fructus Crataegi and Endothelium Corneum Gigeriae Galli, and said Fructus Crataegi and the Endothelium Corneum Gigeriae Galli ratio of weight and number in said Chinese medicine is Fructus Crataegi 3～6 weight portions, Endothelium Corneum Gigeriae Galli 2～4 weight portions.
Wherein, said Chinese medicine can also comprise Fructus Ligustri Lucidi and Herba Ecliptae, and said Fructus Ligustri Lucidi and the Herba Ecliptae ratio of weight and number in said Chinese medicine is Fructus Ligustri Lucidi 6～10 weight portions, Herba Ecliptae 7～12 weight portions.
Ask in order to solve above-mentioned technology, the invention provides above-mentioned preparation method of Chinese medicine, when the dosage form of said Chinese medicine is decoct, comprise,
The first step with said component proportional mixing, is pulverized;
Second step; Add water in the mixture after pulverizing, decocted 2～4 hours, filter with respect to 2～4 times of said mixture qualities; The water that adds with respect to 1～2 times in said mixture in the filtering residue decocted 1～2 hour once more; Filter, twice filtrating is mixed, being evaporated to crude drug concentration is 1g/ml～3g/ml.
Ask in order to solve above-mentioned technology, the invention provides above-mentioned preparation method of Chinese medicine, when the dosage form of said Chinese medicine is powder, comprise,
The first step drops into blender in proportion with said component and stirred 30～50 minutes, and fully mixing is pulverized;
Second step added the water with respect to 2～4 times of said mixture qualities in the mixture after pulverizing, and decocted 2～4 hours; Filter, the water that adds with respect to 1～2 times in said mixture in the filtering residue decocted 1～2 hour once more, filtered; Twice filtrating is mixed, and concentrating under reduced pressure is removed moisture, obtains dried mastic; The further dry and pulverizing with spray dryer, sieving obtains 50～100 order Chinese powder medicine fine powders.
Ask that in order to solve above-mentioned technology the invention provides a kind of feedstuff, it comprises feed additive and feed vector, said feed additive comprises that above-mentioned Chinese medicine is as additive.
Wherein, with respect to the feed additive of 100 weight portions, the addition of said Chinese medicine additive can be 30～70 weight portions.
Wherein, can also comprise acidulant in the said feed additive, with respect to the feed additive of 100 weight portions; The addition of said acidulant can be 10～30 weight portions; Said acidulant comprises one or more mixing in L-lactic acid, fumaric acid, the citric acid, and when said acidulant was the mixture of above-mentioned several kinds of materials, the weight fraction of each component was than being L-lactic acid 25～35 weight portions; Fumaric acid 15～30 weight portions, citric acid 20～30 weight portions.
Beneficial effect of the present invention:
With respect to the medicine that is used to prevent and treat Pullorum Disease of the prior art, adopt this Chinese medicine composition to prevention and the treatment of the chicken that suffers from Pullorum Disease have efficiently, toxic and side effects is little, noresidue, do not develop immunity to drugs, free from environmental pollution, can increase Abwehrkraft des Koepers, short treating period, effect rapid, cheap, have and advantage such as apply.
The specific embodiment
The Pullorum Disease source of infection is extensive, and circulation way is complicated, but brief overview is vertical transmission and horizontal transmission dual mode.After the egg that promptly carries disease germs went into to incubate, the Hakuri bacterium bred rapidly in the egg, causes the part embryonic death, and the chickling after hatching then becomes the young bird that carries disease germs, and the survival chicken is the chicken that carries disease germs.Its manure contamination environment and water, material, apparatus etc. scatter cause of disease, infect other healthy chicken, become the horizontal transmission source; On the other hand through the copulation of carrying disease germs, produce the egg that carries disease germs again and incorporate into and incubate.So move in circles, go round and begin again, pass on from generation to generation, form multipath and propagate chain.
The clinical symptoms of chickling Pullorum Disease mainly is the weak young bird that stillborn fetus in hatching process, occurs, can not go out shell, sees at brooder that weak young bird all belongs in the egg and infects.Sudden death can take place in sick young weak no appetite.Sometimes 5～10 talentes see the Hakuri case after going out shell, increase the weight of day by day in subsequently 7～10 days, reach dead peak in the 2nd, the 3rd week usually, and its pathological change is mainly, and prominent dead chickling hepatomegaly has striped congested.Also have other internal organs congested at septic, yolk sac absorbs bad (content is a yellowy butyrous or cheesy).The course of disease is grown, and the heart, liver, lung, caecum, large intestine and muscular stomach have downright bad tuberosity, and liver also has petechial hemorrhage.The nephremia or anemia, ureter is expanded because of being full of urate.Caecum has cheesy thing, is mixed with blood sometimes.Young hemorrhagic pneumonia in 10 ages in days, more older have a liver pathological changes district.Nodosity in the cardiac muscle.
Manifest symptom does not take place for propagating for a long time after infecting in the clinical symptoms of the chicken Pullorum Disease of growing up, but laying rate, rate of fertilization, incubation rate descend.In chicken with breed chicken performance cockscomb atrophy anemia, wing descends, head and neck is rolled up dysentery, few food or do not eat the course of disease 4～5 days, weak point person's death in 1 day.The pathological change of adult chicken is mainly the ovum distortion, and variable color is cryptomere, peritonitis, acute or chronic pericarditis.The ovum of being injured contains grease or cheese thing and is attached on the ovary at the peplos of a bed thickness.The common pericarditis of public hen, the lighter's pericardium is transparent relatively poor, and pericardial fluid increases, has the folliculus bag of amber caseous substance, or is embedded in the abdominal cavity fat, or invests on stomach or the intestinal wall.
Chinese veterinarian thinks that Pullorum Disease is because the chicken internal organs are tender and lovely, and QI and blood does not fill, and the spleen sun is plain empty, and is then wet by interior life; Positive QI-insufficiency, weakened defensive QI, susceptible cold-evil then, empty, wet, cold three heresies mingle and cause a disease, and therefore treating to be principle with heat-clearing and toxic substances removing, relieving diarrhea with astringents, replenishing QI to invigorate the spleen.
Based on mentioned above principle, Chinese medicine composition of the present invention comprises: Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Pulsatillae, the Rhizoma Anemarrhenae, Spica Prunellae, Flos Lonicerae, Radix Scrophulariae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Nelumbinis, Fructus Mume, Pericarpium Granati, Semen Coicis.
The mechanism of Chinese herb prevention Pullorum Disease is: the specificity of enhancing body and nonspecific immunity comprise the generation that increases antibody and complement, increase production of cytokines; Suppress virus breeding (suppressing the expression of body inner virus mRNA); Remove harmful free radical; Antibiotic, elimination complication; Protect the liver and protect kidney, thereby guarantee normal physiological function and the resistance against diseases of eliminating paathogenic factor.
Each component pharmacology is following:
Rhizoma Coptidis: bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, stomach, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, the effect of cooling blood for improving eyesight; Cure mainly damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever; Hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache; Quench one's thirst carbuncle furuncle, eczema, eczema, auditory meatus card such as suppurate; Rhizoma Coptidis is a light broad spectrum antiviral drug thing, can effectively reduce the drug resistance of Salmonella, and staphylococcus aureus, blood dissolubility streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacterium etc. are had stronger bacteriostasis, amplification on Canon of Materia Medica: how moderns are with controlling dysentery, and lid is held with the dry justice of hardship.Down valgar but see that intestinal void is oozed and let out, little seemingly have a hemafecia, promptly uses it, more do not know to end.Ignore again cold and heat what, but with most agent degree of being, by being that to cause danger tired more.If QI excess is just sick, the overabundant heat dysentery, just ending of clothes still needn't be use up agent also.Or empty and cold, then must not obey.Surplus like " warp ".
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, return liver, kidney, large intestine, small intestine meridian, bladder, heart channel, have the effect of heat clearing and damp drying, wind dispelling insecticide, cure mainly intermittent fever and go mad; The pyretic toxicity blocked-up chest is quenched one's thirst, damp-heat dysentery, discharging fresh blood stool; Leukorrhagia pudendal pruritus, jaundice, hot urination, rubella pruritus; Scabies, leprosy, cards such as noxious dampness skin infection, Radix Sophorae Flavescentis all has the obvious suppression effect to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus.
The Radix Pulsatillae: bitter in the mouth, cold in nature, go into stomach, large intestine channel, have heat-clearing and toxic substances removing, the effect of eliminating pathogenic heat from blood to cure dysentery, being mainly used in gastrointestinal has damp and hot stagnant heating stomachache, dysentery pus and blood, cards such as tenesmus; To the hematodiarrhoea hematochezia better effects if of large intestine heat in blood, dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus, Sha Shi door bacterium there is stronger inhibitory action.
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, go into lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough cures mainly fever caused by exogenous pathogenic factors, and hyperpyrexia is irritated, lung-heat type cough, interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and goes into edema caused by disorder of QI, the intenseness of heat impairment of body fluid; Also be used to treat diabetes; Phlegm-heat obstructing in the lung and breathing heavily, the xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.
Spica Prunellae: cold in nature, bitter in the mouth, suffering are returned liver, gallbladder meridian, have the effect of liver heat removing and eyesight improving, powder detoxifcation, are used for conjunctival congestion and swelling pain, order pearl nyctalgia, and it is dizzy to have a headache, scrofula, goiter swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity have the obvious suppression effect to dysentery bacterium, cholera bacilli, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus.
Flos Lonicerae: sweet in the mouth, cold in nature, go into the heart, lung, stomach, large intestine channel, the effect of heat-clearing and toxic substances removing is arranged, holding concurrently can eliminating pathogenic heat from blood to cure dysentery, is mainly used in affection due to external wind and heat, the epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; The fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has antipyretic effect preferably, and antiinflammatory action is arranged, and can promote leukocytic phagocytic function, and multiple pyococcus and pathogenic entero becteria are had stronger bacteriostasis.
Radix Scrophulariae: bitter in the mouth, sweet, salty, cold nature is gone into lung, stomach, kidney channel, has the effect of clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens, be used for warm febrile disease join the army blood, intense heat in both QI and blood systems, send out the speckle dermexanthesis; Constipation, hectic fever due to YIN-deficiency chronic cough are hindered in consumption of YIN caused by febrile disease, Tianjin; Conjunctival congestion is red and swollen, have sore throat, the treatment of card such as too fat to move sore, and Radix Scrophulariae has the obvious suppression effect to staphylococcus aureus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, group B streptococcus, escherichia coli, shigella flexneri.
Radix Codonopsis: sweet in the mouth, property is flat, goes into lung, spleen channel, and the QI invigorating strengthening the spleen is arranged; The effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach; Transfer regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve modulation on immune status, disease resistance enhancemen; Facilitating digestion absorbs; Improve metabolism, promote the absorption of intestinal to nutrient substance, Radix Codonopsis is inhibited to meningococcus, diphtheria corynebacterium, catalin diplococcus, paracolon and escherichia coli.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature, go into spleen, stomach warp, have invigorating the spleen and benefiting QI; The dampness diuretic, strengthening superficial resistance to stop perspiration, antiabortive effect is used for weakness of the spleen and stomach; The lack of appetite distension, fatigue and weakness is had loose bowels; Effects such as water-damp retention, phlegm retention, edema, cards such as exterior deficiency spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae have adjustment gastrointestinal motility function, antiulcer, protect the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction; The Rhizoma Atractylodis Macrocephalae has effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor; Can improve body's immunological function; Leukocyte increasing quantity, inhibited to staphylococcus aureus, Hemolytic streptococcus, meningococcus, bacillus subtilis etc.
Semen Nelumbinis: sweet in the mouth, puckery, property is flat, returns spleen, kidney, heart channel, has the effect of spleen reinforcing antidiarrheal, supplementing the kidney to control the nocturnal, tranquilizing by nourishing the heart, is used for weakness of the spleen and stomach, and lack of appetite is weak, and vomiting is had loose bowels, and it is not solid to suffer from a deficiency of the kidney, emission and spermatorrhea, nocturnal emission turbid urine, malaise, cardiac muscle, cards such as insomnia.
Fructus Mume: bitter in the mouth, acid, puckery, warm in nature, return liver, lung, spleen, large intestine channel, have and astringe the lung; Astringing intestine to stop diarrhea, hemostasis, the effect of promoting the production of body fluid, it is more than to be used to treat chronic dysentery; Damp-heat dysentery is had blood in stool, card such as hematuria, snowslide, and is inhibited to multiple pathogenic bacterias such as dysentery bacterium, escherichia coli, Bacillus typhi.
Pericarpium Granati: sour in the mouth, puckery, warm in nature, return large intestine, kidney channel; Has relieving diarrhea with astringents, hemostasis, parasiticidal effect; Be used for the chronic diarrhea chronic dysentery, discharging fresh blood stool, bleeding not during menses; Cards such as abdominal pain due to worm stagnation, Pericarpium Granati is inhibited to multiple pathogenic bacterias such as staphylococcus aureus, dysentery bacterium, escherichia coli, Bacillus typhi.
Semen Coicis: sweet in the mouth, light, cold nature is returned lung, spleen, large intestine channel, and invigorating the spleen to arrest diarrhea is arranged, the diuretic eliminating impediment, the effect of row's skin ulcer pus is mainly used in wet the having loose bowels of lung stomach of being stranded; Damp is invaded the hydrosarca of stain skin, dysuria; The damp and hot resistance in the numbness of QI and blood passes to and the scorchingly hot cards such as lung abscess in the lung intestinal, acute appendicitis that pent up.
Further preferred, the said Chinese medicine composition that is used to treat Pullorum Disease only is made up of said components.
During Chinese medicine of the present invention has bacteriogenic endotoxin and extracellular toxin and destruction; The defense function of ability enhancing body, the phagocytosis of enhancing cell promotes effects such as lymphocytic conversion ratio; Thereby improve the resistance infection of body; Help to improve digestive function simultaneously, promote appetite, health invigorating.
The said Chinese medicine composition that is used for treating Pullorum Disease, the ratio of weight and number of various components can be preferably:
Rhizoma Coptidis 33～39 weight portions, Radix Sophorae Flavescentis 13～19 weight portions, the Radix Pulsatillae 42～49 weight portions, the Rhizoma Anemarrhenae 36～42 weight portions, Spica Prunellae 17～21 weight portions, Flos Lonicerae 23～30 weight portions, Radix Scrophulariae 12～18 weight portions, Radix Codonopsis 25～32 weight portions, the Rhizoma Atractylodis Macrocephalae 20～26 weight portions, Semen Nelumbinis 15～22 weight portions, Fructus Mume 13～18 weight portions, Pericarpium Granati 10～16 weight portions, Semen Coicis 9～14 weight portions.
The said Chinese medicine composition that is used for treating the animal Pullorum Disease, the ratio of weight and number of various components also can further be preferably: Rhizoma Coptidis 36～39 weight portions, Radix Sophorae Flavescentis 16～19 weight portions, the Radix Pulsatillae 46～49 weight portions, the Rhizoma Anemarrhenae 39～42 weight portions, Spica Prunellae 19～21 weight portions, Flos Lonicerae 26～30 weight portions, Radix Scrophulariae 15～18 weight portions, Radix Codonopsis 28～32 weight portions, the Rhizoma Atractylodis Macrocephalae 23～26 weight portions, Semen Nelumbinis 19～22 weight portions, Fructus Mume 15～18 weight portions, Pericarpium Granati 13～16 weight portions, Semen Coicis 12～14 weight portions.
Eliminate eating accumulation for promoting ill chicken; Facilitating digestion absorbs; The said Chinese medicine composition that is used for preventing and treats Pullorum Disease can also comprise Fructus Crataegi and Endothelium Corneum Gigeriae Galli; Said Fructus Crataegi and the Endothelium Corneum Gigeriae Galli ratio of weight and number in said Chinese medicine composition is Fructus Crataegi 3～6 weight portions, Endothelium Corneum Gigeriae Galli 2～4 weight portions.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature is gone into spleen, stomach, Liver Channel, is used for promoting digestion and invigorating the stomach, and the circulation of qi promoting dissipating blood stasis mainly is used for treating accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple of treatment dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus etc. had the obvious suppression effect.
Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature, go into spleen, stomach, small intestinal, urinary bladder channel; There are strengthening the spleen to promote digestion, arresting seminal emission to end the effect of drowning, are mainly used in the distension and fullness in the abdomen of food stagnation stagnation, heating installation diarrhoea; Symptoms such as children's's infantile malnutrition, Endothelium Corneum Gigeriae Galli can promote effects such as gastric secretion, enhancing gastric peristalsis, acceleration gastric emptying.
Through adding these two kinds of auxiliary elements of Fructus Crataegi and Massa Medicata Fermentata, can eliminate eating accumulation and advance digestion, increase enterogastric peristalsis, in case distension and fullness in the abdomen; Lack of appetite, dysentery has and regulates the flow of vital energy, stomach function regulating; The effect of spleen invigorating makes ill chicken food desire to heighten, disease resistance enhancemen and immunologic function; Reduce disease incidence rate, play a role in health care, thus prevention and treatment Pullorum Disease.
The said Chinese medicine composition that is used for preventing and treats Pullorum Disease can also comprise Fructus Ligustri Lucidi and Herba Ecliptae, and said Fructus Ligustri Lucidi and the Herba Ecliptae ratio of weight and number in said Chinese medicine composition is Fructus Ligustri Lucidi 6～10 weight portions, Herba Ecliptae 7～12 weight portions.
Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, go into liver, kidney channel, strong liver kidney tonifying is arranged, the effect of clearing away heat to improve acuity of vision is mainly used in the treatment hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, symptoms such as interior-heat caused by deficiency of YIN.Fructus Ligustri Lucidi ability promoting leucocytes, the effect of raise immunity has stronger inhibitory action to staphylococcus aureus, dysentery bacterium.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play not liver and kidney tonifying, the effect of cooling blood for hemostasis is used for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Be suitable for the deficiency of YIN hot person is arranged; Be used for treating the haematemesis of the long-pending heat of stomach; Symptoms such as the hemoptysis of injury of blood vessel of the lung by heat, Herba Ecliptae has inhibitory action to staphylococcus aureus, Bacillus typhi, Song Shi dysentery bacterium, bacillus pyocyaneus, obviously enhancing non-specific immunity and cellular immune function.
The present invention also provides the method for preparing of above-mentioned Chinese medicine composition decoct, and it comprises:
The first step with said component proportional mixing, is pulverized;
Second step; Add water in the mixture after pulverizing, decocted 2～4 hours, filter with respect to 2～4 times of said mixture qualities; The water that adds with respect to 1～2 times in said mixture in the filtering residue decocted 1～2 hour once more; Filter, twice filtrating is mixed, being evaporated to crude drug concentration is 1g/ml～3g/ml.
The present invention also provides the method for preparing of above-mentioned Chinese medicine composition composition powders, and it comprises:
The first step drops into blender in proportion with said component and stirred 30～50 minutes, and fully mixing is pulverized;
Second step added the water with respect to 2～4 times of said mixture qualities in the mixture after pulverizing, and decocted 2～4 hours; Filter, the water that adds with respect to 1～2 times in said mixture in the filtering residue decocted 1～2 hour once more, filtered; Twice filtrating is mixed, and concentrating under reduced pressure is removed moisture, obtains dried mastic; The further dry and pulverizing with spray dryer, sieving obtains 50～100 order Chinese medicine composition composition powders fine powders.
The present invention also provides a kind of method for using of above-mentioned Chinese medicine composition, and it comprises: said Chinese medicine composition composition powders is mixed stirring mutually with feed vector, subsequently with the ill chicken of this stirred mixture feeding.
The present invention also provides the another kind of method for using of above-mentioned Chinese medicine composition, and it comprises: said decoct is irritated the ill chicken of stomach, each 1 dose, 4～6 doses of every days.
The present invention also provides a kind of fodder compound, comprises feed additive and feed vector in the said composition, and said feed additive comprises above-mentioned Chinese medicine composition additive.
Said feed vector is preferably one or more in corn, Semen Tritici aestivi, Semen sojae atricolor, Testa Tritici, the Sorghum vulgare Pers. etc.
When said feed vector is mixture, said Testa Tritici 20 ~ 40 weight portions, said corn 5 ~ 10 weight portions, said Semen Tritici aestivi 5 ~ 10 weight portions, said Semen sojae atricolor 10 ~ 20 weight portions, said Sorghum vulgare Pers. 15 ~ 25 weight portions.
With respect to the feed vector of 100 weight portions, the addition of said feed additive can be 8～12 weight portions.
With respect to the feed additive of 100 weight portions, the addition of said Chinese medicine composition additive can be 30～70 weight portions, further is preferably 50～60 weight portions.
Can also comprise acidulant in the said feed additive, can sterilization and anticorrosion through adding acidulant, regulation and control gastrointestinal colony balance; Help the breeding growth of probioticss such as lactobacillus, suppress the quantity of harmful bacterium such as escherichia coli, improve the animal anti-stress effect; Improve animal immunizing power; And can participate in internal metabolism directly, release energy, promote the absorption of mineral, vitamin and nutrient substance.
With respect to the feed additive of 100 weight portions, the addition of said acidulant can be 10～30 weight portions, further is preferably 20～30 weight portions.
Said acidulant comprises one or more mixing in L-lactic acid, fumaric acid, the citric acid.
When said acidulant was the mixture of above-mentioned several kinds of materials, the weight fraction of each component was than being L-lactic acid 25～35 weight portions, fumaric acid 15～30 weight portions, citric acid 20～30 weight portions.
Can also comprise the nutritional labeling supplemented by additives in the said feed additive, with respect to the feed additive of 100 weight portions, the addition of said nutritional labeling supplemented by additives can be 10～30 weight portions, further is preferably 20～30 weight portions.
Said nutritional labeling supplemented by additives can comprise one or more mixing in lysine, methionine, xylose alcoholase, the hemicellulase; And the weight fraction of each component ratio is lysine 10～20 weight portions, methionine 10～20 weight portions, xylose alcoholase 10～20 weight portions, hemicellulase 10～20 weight portions.
Also further add feed adhesive in the said fodder compound, with respect to 100 weight portion feed vectors, the addition of said feed adhesive can be 10～20 weight portions.
Said feed adhesive may further include: one or more in gluten flour, starch, ammonium sulfate and the sodium bicarbonate; Wherein, the weight fraction of various compositions ratio does, gluten flour is 60 ~ 80 parts, and starch is 30 ~ 50 parts; Ammonium sulfate and sodium bicarbonate add up to 3 ~ 8 parts; Said starch is preferably and is corn starch, and wherein farinose ratio of weight and number is 70 ~ 90 parts, and the ratio of weight and number of ripe starch is 10 ~ 20 parts; Said gluten flour is the protein wt degree greater than 15% flour.
The present invention also provides the method for preparing of above-mentioned fodder compound, and it comprises:
The first step prepares the said Chinese medicine composition composition powders as additive as stated above, and dry back is subsequent use;
Second step by said mixed, added the water mixing and stirring with respect to 1 ~ 2 times of mixture quality with L-lactic acid, fumaric acid, citric acid, and send into the spray granulation tower and carry out spray granulation, the particle drying that makes, and sieve, obtain 60 orders ~ 80 purpose acidulant;
In the 3rd step, each component of getting in the feed adhesive is mixed, and adds entry and begins modified; Refining temperature is 62 ~ 68 ℃; The after drying that stirs obtains feed adhesive, with respect to the weight of each component in the feed adhesive of 100 weight portions with, the addition of said water is 15 ~ 30 weight portions;
In the 4th step, one or more mix the back pulverizing with said corn, Semen Tritici aestivi, Fructus Hordei Vulgaris, Semen sojae atricolor and Testa Tritici, and grinding particle size is 300～550 mm, makes its fine powder amount reach more than 92% of total material, obtains feed vector;
In the 5th step, the Chinese medicine composition composition powders, second that the first step is obtained goes on foot the acidulant that obtains, the feed adhesive that the 3rd step obtained, and the feed vector of the 4th step acquisition mixes; Putting into multiplex mixer stirred 120 minutes～150 minutes; It is expanded to put into the ring mode bulking machine after the taking-up, and the temperature of control bulking machine is between 80 ℃～90 ℃, and the expanded time is 1～2 hour; The aridity of control material to be extruded is 90%～95%; Change over to after the taking-up and produce deposition hard particles feedstuff in the ring mode grit machine, use 50 orders ~ 100 meshes to sieve then, obtain said fodder compound.
In the method for preparing of said fodder compound, the 4th step can also further add the nutritional labeling supplemented by additives.
Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.
The toxicity test of embodiment 1 Chinese medicine composition of the present invention
39g Rhizoma Coptidis, 19g Radix Sophorae Flavescentis, the 49g Radix Pulsatillae, the 42g Rhizoma Anemarrhenae, 21g Spica Prunellae, 30g Flos Lonicerae, 18g Radix Scrophulariae, 32g Radix Codonopsis, the 26g Rhizoma Atractylodis Macrocephalae, 22g Semen Nelumbinis, 18g Fructus Mume, 16g Pericarpium Granati, 14g Semen Coicis are mixed, pulverize; Add the water of 1000g in the mixture after pulverizing, decocted 3 hours, filter, the water that adds 400g in the filtering residue decocted 2 hours once more, filtered, and twice filtrating is mixed, and was evaporated to the decoct that crude drug concentration is 3g/ml.
Get the ICR mice, body weight is pressed the body weight random packet at 25～30 grams, and 10 every group, male and female half and half, the oral administration solution administration, dosage only is 5.8ml/.Observed 20 days continuously after the administration, all mices are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, and not seeing has irritative response and other untoward reaction.
Toxicity test proves, not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.
The preparation of embodiment 2 Chinese medicine composition decocts
390g Rhizoma Coptidis, 190g Radix Sophorae Flavescentis, the 490g Radix Pulsatillae, the 420g Rhizoma Anemarrhenae, 210g Spica Prunellae, 300g Flos Lonicerae, 180g Radix Scrophulariae, 320g Radix Codonopsis, the 260g Rhizoma Atractylodis Macrocephalae, 220g Semen Nelumbinis, 180g Fructus Mume, 160g Pericarpium Granati, 140g Semen Coicis are mixed, pulverize; Add the water of 1000g in the mixture after pulverizing, decocted 3 hours, filter, the water that adds 400g in the filtering residue decocted 2 hours once more, filtered, and twice filtrating is mixed, and was evaporated to the decoct that crude drug concentration is 1.5g/ml.
The preparation of embodiment 3 Chinese medicine composition composition powders 1
390g Rhizoma Coptidis, 190g Radix Sophorae Flavescentis, the 490g Radix Pulsatillae, the 420g Rhizoma Anemarrhenae, 210g Spica Prunellae, 300g Flos Lonicerae, 180g Radix Scrophulariae, 320g Radix Codonopsis, the 260g Rhizoma Atractylodis Macrocephalae, 220g Semen Nelumbinis, 180g Fructus Mume, 160g Pericarpium Granati, 140g Semen Coicis mix, and pulverize; Add the water of 10000g in the mixture after pulverizing, decocted 3 hours, filter; The water that adds 4000g in the filtering residue decocted 2 hours once more, filtered, and twice filtrating is mixed; The concentrating under reduced pressure branch that anhydrates; Obtain dried mastic, further dry and pulverizing with spray dryer, sieving obtains 70 order Chinese medicine composition composition powders fine powders 1.
The preparation of embodiment 4 Chinese medicine composition composition powders 2
360g Rhizoma Coptidis, 160g Radix Sophorae Flavescentis, the 460g Radix Pulsatillae, the 390g Rhizoma Anemarrhenae, 190g Spica Prunellae, 260g Flos Lonicerae, 150g Radix Scrophulariae, 280g Radix Codonopsis, the 230g Rhizoma Atractylodis Macrocephalae, 190g Semen Nelumbinis, 150g Fructus Mume, 130g Pericarpium Granati, 120g Semen Coicis mix, and pulverize; Add the water of 9000g in the mixture after pulverizing, decocted 3 hours, filter; The water that adds 350g in the filtering residue decocted 2 hours once more, filtered, and twice filtrating is mixed; The concentrating under reduced pressure branch that anhydrates; Obtain dried mastic, further dry and pulverizing with spray dryer, sieving obtains 50 order Chinese medicine composition composition powders fine powders 2.
The preparation of embodiment 5 fodder compounds 1
Get the Chinese medicine composition composition powders 1 of embodiment 3 preparations, dry back is subsequent use; 300gL-lactic acid, 200g fumaric acid, 250g citric acid are mixed, add 1000g water mixing and stirring, send into the spray granulation tower and carry out spray granulation, the particle drying that makes, and sieve, obtain 70 purpose acidulant; Getting 700g gluten flour, 400g corn starch, 20g ammonium sulfate and 40g sodium bicarbonate mixes; Wherein farinose ratio of weight and number is 80 parts; The ratio of weight and number of ripe starch is 20 parts, and gluten flour is 17% flour for the protein wt degree, adds 300g water and begins modified; Refining temperature is 68 ℃, and the after drying that stirs obtains feed adhesive; 3000g Testa Tritici, 700g corn, 600g Semen Tritici aestivi, 1500g Semen sojae atricolor, 200g Sorghum vulgare Pers. are mixed the back pulverize, grinding particle size is 300mm, makes its fine powder amount reach 95% of total material, obtains feed vector; With 350g Chinese medicine composition composition powders 1,150g acidulant, 750g feed adhesive; The 5000g feed vector mixes, and puts between the multiplex mixer stirring, and the expanded time is 2 hours; The aridity of control material to be extruded is 95%; Change over to after the taking-up and produce deposition hard particles feedstuff in the ring mode grit machine, sieve with 50 meshes then, obtain said fodder compound 1.
The preparation of embodiment 6 fodder compounds 2
Get the Chinese medicine composition composition powders 2 of embodiment 4 preparations, dry back is subsequent use; 300gL-lactic acid, 200g fumaric acid, 250g citric acid are mixed, add 1000g water mixing and stirring, send into the spray granulation tower and carry out spray granulation, the particle drying that makes, and sieve, obtain 70 purpose acidulant; Getting 700g gluten flour, 400g corn starch, 20g ammonium sulfate and 40g sodium bicarbonate mixes; Wherein farinose ratio of weight and number is 80 parts; The ratio of weight and number of ripe starch is 20 parts, and gluten flour is 17% flour for the protein wt degree, adds 300g water and begins modified; Refining temperature is 68 ℃, and the after drying that stirs obtains feed adhesive; 3000g Testa Tritici, 700g corn, 600g Semen Tritici aestivi, 1500g Semen sojae atricolor, 200g Sorghum vulgare Pers. are mixed the back pulverize, grinding particle size is 300mm, makes its fine powder amount reach 95% of total material, obtains feed vector; With 350g Chinese medicine composition composition powders 2,150g acidulant, 750g feed adhesive; The 5000g feed vector mixes, and puts between the multiplex mixer stirring, and the expanded time is 2 hours; The aridity of control material to be extruded is 95%; Change over to after the taking-up and produce deposition hard particles feedstuff in the ring mode grit machine, sieve with 50 meshes then, obtain said fodder compound 2.
Embodiment 7 clinical experiments
Experiment material
Bacterial strain: die from the chickling isolation identification Pullorum Disease Salmonella of the white scour of chicken from the locality, it is subsequent use to put 37 ℃ of cultivation 24 ~ 48h with broth medium.
Medicine:
Western medicine: berberine 10mg/mL, furazolidone 20mg/mL;
Chinese medicine: the Chinese medicine composition decoct of the embodiment of the invention 2 preparations.
The prevention experiment:
200 healthy parts in Beijing opera spoken in Beijing dialect chickling (5 age in days) are divided into 4 groups at random, Chinese medicine counteracting toxic substances group 2mL decoct every every day of the present invention, Western medicine counteracting toxic substances group furazolidone group is fed to account for 0.02% of feedstuff; The blank group is not fed any medicine; Chinese medicine counteracting toxic substances group, Western medicine counteracting toxic substances group, not administration counteracting toxic substances group are behind the medication 4d, with above-mentioned Salmonella broth culture (5 times of diluents of 1,000,000,000 bacterium/mL); Lumbar injection 0.3mL/, observed and recorded each group morbidity and dead chicken number.
The treatment experiment:
To use 300 (5 age in days) parts in Beijing opera spoken in Beijing dialect chickling of Salmonella cultured solution of broth lumbar injection to be divided into 3 groups at random, and occur treating with different medicines behind the clinical card shape.The test chicken dose: treatment by Chinese herbs group 3mL decocting liquid every every day of the present invention, furazolidone group medicine accounts for 0.04% of feedstuff, and matched group is not fed any medicine.
The result:
Chinese herbs decoction of the present invention is to the preventive effect of Pullorum Disease, and the result sees table 1.
Table 1 Pullorum Disease preventive effect
Can know that through table 1 Chinese medicine composition decoct of the present invention will obviously be better than Western medicine group to the preventive effect of Pullorum Disease, has good effect, the Chinese medicine composition decoct is more higher than Western medicine antibacterials to the preventive effect of Pullorum Disease salmonellosis.
Chinese herbs decoction of the present invention is to the therapeutic effect of Pullorum Disease, and the result sees table 2.
Table 2 Pullorum Disease therapeutic effect
Can know that through table 2 Chinese medicine composition decoct of the present invention will obviously be better than Western medicine group to the therapeutic effect of Pullorum Disease, the Chinese medicine composition decoct is more higher than Western medicine antibacterials to the therapeutic effect of Pullorum Disease salmonellosis.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (10)
1. a Chinese medicine that prevents and treat Pullorum Disease is characterized in that, comprising: Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Pulsatillae, the Rhizoma Anemarrhenae, Spica Prunellae, Flos Lonicerae, Radix Scrophulariae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Nelumbinis, Fructus Mume, Pericarpium Granati, Semen Coicis.
2. Chinese medicine as claimed in claim 1; It is characterized in that: the ratio of weight and number of each component in the said Chinese medicine is Rhizoma Coptidis 33～39 weight portions, Radix Sophorae Flavescentis 13～19 weight portions, the Radix Pulsatillae 42～49 weight portions, the Rhizoma Anemarrhenae 36～42 weight portions, Spica Prunellae 17～21 weight portions, Flos Lonicerae 23～30 weight portions, Radix Scrophulariae 12～18 weight portions, Radix Codonopsis 25～32 weight portions, the Rhizoma Atractylodis Macrocephalae 20～26 weight portions, Semen Nelumbinis 15～22 weight portions, Fructus Mume 13～18 weight portions, Pericarpium Granati 10～16 weight portions, Semen Coicis 9～14 weight portions.
3. according to claim 1 or claim 2 Chinese medicine; It is characterized in that: the ratio of weight and number of each component in the said Chinese medicine is Rhizoma Coptidis 36～39 weight portions, Radix Sophorae Flavescentis 16～19 weight portions, the Radix Pulsatillae 46～49 weight portions, the Rhizoma Anemarrhenae 39～42 weight portions, Spica Prunellae 19～21 weight portions, Flos Lonicerae 26～30 weight portions, Radix Scrophulariae 15～18 weight portions, Radix Codonopsis 28～32 weight portions, the Rhizoma Atractylodis Macrocephalae 23～26 weight portions, Semen Nelumbinis 19～22 weight portions, Fructus Mume 15～18 weight portions, Pericarpium Granati 13～16 weight portions, Semen Coicis 12～14 weight portions.
4. like the described Chinese medicine of claim 1 to 3, it is characterized in that: said Chinese medicine can also comprise Fructus Crataegi and Endothelium Corneum Gigeriae Galli, and said Fructus Crataegi and the Endothelium Corneum Gigeriae Galli ratio of weight and number in said Chinese medicine composition is Fructus Crataegi 3～6 weight portions, Endothelium Corneum Gigeriae Galli 2～4 weight portions.
5. the described Chinese medicine of claim 1 to 4, it is characterized in that: said Chinese medicine can also comprise Fructus Ligustri Lucidi and Herba Ecliptae, said Fructus Ligustri Lucidi and the Herba Ecliptae ratio of weight and number in said Chinese medicine is Fructus Ligustri Lucidi 6～10 weight portions, Herba Ecliptae 7～12 weight portions.
6. the described preparation method of Chinese medicine of claim 1 to 5 is characterized in that:
When the dosage form of said Chinese medicine is decoct, comprise,
The first step with said component proportional mixing, is pulverized;
Second step; Add water in the mixture after pulverizing, decocted 2～4 hours, filter with respect to 2～4 times of said mixture qualities; The water that adds with respect to 1～2 times in said mixture in the filtering residue decocted 1～2 hour once more; Filter, twice filtrating is mixed, being evaporated to crude drug concentration is 1g/ml～3g/ml.
7. the described preparation method of Chinese medicine of claim 1 to 5 is characterized in that:
When the dosage form of said Chinese medicine is powder, comprise,
The first step drops into blender in proportion with said component and stirred 30～50 minutes, and fully mixing is pulverized;
Second step added the water with respect to 2～4 times of said mixture qualities in the mixture after pulverizing, and decocted 2～4 hours; Filter, the water that adds with respect to 1～2 times in said mixture in the filtering residue decocted 1～2 hour once more, filtered; Twice filtrating is mixed, and concentrating under reduced pressure is removed moisture, obtains dried mastic; The further dry and pulverizing with spray dryer, sieving obtains 50～100 order Chinese powder medicine fine powders.
8. feedstuff, it is characterized in that: comprise feed additive and feed vector, said feed additive comprises that the described Chinese medicine of claim 1 to 5 is as additive.
9. feedstuff as claimed in claim 8 is characterized in that: with respect to the feed additive of 100 weight portions, the addition of said Chinese medicine additive can be 30～70 weight portions.
10. like claim 8 or 9 described feedstuffs; It is characterized in that: can also comprise acidulant in the said feed additive; With respect to the feed additive of 100 weight portions, the addition of said acidulant can be 10～30 weight portions, and said acidulant comprises one or more mixing in L-lactic acid, fumaric acid, the citric acid; When said acidulant is the mixture of above-mentioned several kinds of materials; The weight fraction of each component is than being L-lactic acid 25～35 weight portions, fumaric acid 15～30 weight portions, citric acid 20～30 weight portions.
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| CN103478508A (en) * | 2013-10-22 | 2014-01-01 | 山东新希望六和集团有限公司 | Chinese medicinal composition and feed for improving chicken immunity and preparation method of composition and feed |
| CN103518995A (en) * | 2013-08-31 | 2014-01-22 | 安徽晨诺饲料油脂加工有限公司 | Traditional Chinese herbal feed for preventing and treating white diarrhea of chicks and preparation method for feed |
| CN105230569A (en) * | 2015-11-11 | 2016-01-13 | 覃政强 | Broiler chicken breeding method |
| CN105284727A (en) * | 2015-11-11 | 2016-02-03 | 覃政强 | Broiler chicken breeding method |
| CN105494950A (en) * | 2015-12-23 | 2016-04-20 | 铜陵润生生态养殖有限公司 | Chicken feed additive for preventing avian staphylocosis and pullorum disease |
| CN106071090A (en) * | 2016-07-13 | 2016-11-09 | 王达文 | A kind of anti-diarrhea Chinese medicine compound feed additive and preparation method and application |
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| CN106982987A (en) * | 2017-03-29 | 2017-07-28 | 安徽省微科生物科技有限公司 | A kind of feed addictive for preventing and treating DISEASE IN FLOCKS |
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| CN103055108A (en) * | 2012-12-04 | 2013-04-24 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating dysentery of livestock and poultry and preparation method of compound propolis composition |
| CN103055108B (en) * | 2012-12-04 | 2014-07-09 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating dysentery of livestock and poultry and preparation method of compound propolis composition |
| CN103518995A (en) * | 2013-08-31 | 2014-01-22 | 安徽晨诺饲料油脂加工有限公司 | Traditional Chinese herbal feed for preventing and treating white diarrhea of chicks and preparation method for feed |
| CN103478508A (en) * | 2013-10-22 | 2014-01-01 | 山东新希望六和集团有限公司 | Chinese medicinal composition and feed for improving chicken immunity and preparation method of composition and feed |
| CN105230569A (en) * | 2015-11-11 | 2016-01-13 | 覃政强 | Broiler chicken breeding method |
| CN105284727A (en) * | 2015-11-11 | 2016-02-03 | 覃政强 | Broiler chicken breeding method |
| CN105494950A (en) * | 2015-12-23 | 2016-04-20 | 铜陵润生生态养殖有限公司 | Chicken feed additive for preventing avian staphylocosis and pullorum disease |
| CN106071090A (en) * | 2016-07-13 | 2016-11-09 | 王达文 | A kind of anti-diarrhea Chinese medicine compound feed additive and preparation method and application |
| CN106615912A (en) * | 2016-09-30 | 2017-05-10 | 安徽华澳生物技术有限公司 | Feed additive for preventing and treating pullorum disease of chicks of 1-30 days old |
| CN106982987A (en) * | 2017-03-29 | 2017-07-28 | 安徽省微科生物科技有限公司 | A kind of feed addictive for preventing and treating DISEASE IN FLOCKS |
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