CN105535720A - Chinese herbal medicinal composition for preventing and treating chick bronchitis, and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese herbal medicinal composition for preventing and treating chick bronchitis, and a preparation method thereof, and belongs to the technical fields of poultry disease prevention and treatment and poultry feed additives. The Chinese herbal medicinal composition is prepared from 28 Chinese herbal medicines comprising Elephantopus scaber L., honeysuckle stem, menthol, Chinese fevervine herb, Black Nightshade, Rhizoma Arisaematis, Herba Houttuyniae and so on through scientific compounding. The composition has the efficacy of clearing heat and detoxifying, removing phlegm and dampness, and reliving cough and calming panting, and also has the efficacy of nourishing yin and generating body fluid, moistening lung and clearing heart heat, nourishing yin and reducing internal heat, and moisturizing dryness and smoothing intestine, the composition can enhance the immunity of chickens as a medicine treatment agent or a feed additive through function complementation and synergism, and the composition allows chicken using the composition to have full energy, brilliant feather, obviously increased appetite and fast growth speed, and has a very good treatment effect on symptoms of the chick bronchitis.

Description

A kind of herbal composite preventing and treating chicken bronchitis and preparation method thereof

Technical field

The present invention relates to poultry disease control and livestock fodder additives technical field, especially herbal composite relating to chicken bronchitis and its preparation method and application.

Background technology

Infectious bronchitis of chicken is caused by infectious bronchitis virus, and the one of chicken is acute, high degree in contact respiratory infectious disease.This disease is widely current in all over the world, be the important epidemic disease of poultry husbandry, morbidity season is more common in Qiu Mozhi spring Mo next year, but the most serious with winter, environmental factors is hot and cold, crowded, improper ventilation mainly, particularly strong stress as vaccination, turn group etc. can bring out this disease occur.It is characterized in that disease pertussis is coughed, sneeze, dyspnea, trachea send rale, can there is watery nasal discharge in chickling, and laying hen is laid eggs and reduces and egg inferior.The incubation period of infectious bronchitis of chicken natural infection is 36 hours or more longer, and sickness rate is high, and the mortality rate of chickling can reach more than 25%, absence of prodrome, full group almost simultaneously sudden onset.Initial performance respiratory symptom, rhinorrhea, shed tears, swelling of the nose is swollen, cough, sneeze, stretch neck and dehisce to breathe.Hear obviously hoarse cry night.Along with PD, exacerbation of symptoms, drop-head closes order, the wing that hangs down squeezes heap, inappetence, drink wish increase, and as treated not in time, has sporadic deaths phenomenon.

At present effective Therapeutic Method be there is no to this disease, people commonly use the symptomatic therapy of the combination of Chinese and Western medicine, as used, cough with asthma is quick, moroxydine hydrochloride etc., due to the normal concurrent bacterial disease of chicken group in actual production, therefore adopts some antibacterials such as doxycycline, ofloxacin sometimes to seem effective.Commercially available also have herbal medicine to treat this disease, but due to formula and using method not rigorous, therapeutic effect is also barely satisfactory.Therefore, the improvement for the treatment of on the medicine of infectious bronchitis of chicken is the technical problem needing solution at present badly.Chinese herbal medicine is the treasure of China, continues to use with a long history, the record of just useful Chinese herbal medicine diseases prevention before more than 2000 years.Along with the development of modern aviculture intensive manufacture, antibiotic, synthetic antimicrobial class medicine and biovaccine etc. are widely used in poultry disease prevention and control and breeding production, and cause animal to produce drug resistance and toxic and side effects, Chinese herbal medicine then has the advantage of self uniqueness.Chinese herbal medicine with its natural sex, multifunctionality, have no drug resistance, the feature such as toxic and side effects is little, in Carnis Gallus domesticus, egg, not easily produce hazard residue as chicken feed addictive, and there is unique pharmacological action, be day by day subject to people's attention.

Using Chinese herbal medicine as treatment chicken bronchitis, existing relevant report at present, if Chinese patent CN103272025A is using Flos Lonicerae, Semen Armeniacae Amarum and the Fructus Momordicae medicine as treatment chicken bronchitis, to reach heat-clearing toxin-expelling functions.And the ubiquitous problem of current technical scheme is: raw materials used price is high, when consumption is few, effect is not remarkable, and when consumption is large, feeding cost significantly increases, and does not have economic worth, and occurs the problem of fighting for valuable Chinese herbal medicine resource with the mankind.Even if cost is not too high, but because formula is simple or proportioning is not optimum, its synergistic function is limited.

Mountain path Caulis et Folium Hyptidis suaveolentis chicken is a kind of high quality meat chicken from Sanhuang chicken selection-breeding, because its present position is in Guangxi Yulin Rong County, puts in a suitable place to breed near the mountain path mountain of famous Taoist mountain-all on mountain, therefore named mountain path Caulis et Folium Hyptidis suaveolentis chicken, the mountain path Caulis et Folium Hyptidis suaveolentis chicken trade mark of having registered in Administration for Industry and Commerce at present.The applicant started the research and extension application of mountain path Caulis et Folium Hyptidis suaveolentis chicken production technology in 2008, by selecting fine quality, and be devoted to the research of Chinese herbal medicine additive, utilize herbal control commonly encountered diseases, according to Chinese veterinarian's benefiting qi and nourishing blood, the principles of formulating prescriptions in Fu Yin Yiyang, optimize with Elephantopus scaber L., Caulis Lonicerae, Herba Paederiae, Herba Solani Nigri, the resourceful medical herbs such as Rhizoma Arisaematis is as the additive formulations of primary raw material, add in daily ration and feed, cultivate the mountain path Caulis et Folium Hyptidis suaveolentis chicken delivered for sale and there is nonreactive, full ecology, organism ability is strong, feature Fresh & Tender in Texture, and it is nutritious, sweet perfume (or spice) is tasty and refreshing, without fishy smell, thick protein, every flavor quality such as inosinic acid nutritive index is significantly higher than same kind, other high-quality indigenous chicken kinds of China of the same type.Broiler quality level can be promoted, promote poultry husbandry development, for promoting that realizing the sustainable development of meat product quality safety contributes.

Summary of the invention

Goal of the invention of the present invention is: for above-mentioned Problems existing, provides a kind of herbal composite preventing and treating chicken bronchitis and its preparation method and application method, has heat-clearing and toxic substances removing, expectorant is dried, effect of relieving cough and asthma.

To achieve these goals, the technical solution used in the present invention is as follows:

A kind of Chinese medicine composition preventing and treating chicken bronchitis, be made up of the herbal raw material of following weight portion: Elephantopus scaber L. 18 ~ 35 parts, Caulis Lonicerae 25 ~ 40 parts, Mentholum 20 ~ 45 parts, Herba Paederiae 20 ~ 40 parts, Herba Solani Nigri 12 ~ 25 parts, Rhizoma Arisaematis 10 ~ 20 parts, Herba Houttuyniae 20 ~ 50 parts, the Rhizoma Anemarrhenae 15 ~ 30 parts, Ramulus Cinnamomi 22 ~ 36 parts, orange 15 ~ 25 parts, Bulbus Fritillariae Cirrhosae 10 ~ 20 parts, Folium Eriobotryae 12 ~ 30 parts, Cortex Mori 16 ~ 27 parts, Radix Platycodonis 8 ~ 20 parts, 8 ~ 20 parts, TianXing wood, Bulbus Lilii 6 ~ 18 parts, Radix Panacis Quinquefolii 2 ~ 10 parts, Radix Adenophorae (Radix Glehniae) 5 ~ 15 parts, 10 ~ 20 parts, Semen Armeniacae Amarum, Radix Asteris 15 ~ 30 parts, the Radix Stemonae 20 ~ 35 parts, Pheretima 12 ~ 25 parts, Concha Solen gouldii Siberian cocklebur 25 ~ 50 parts, Radix Isatidis 10 ~ 25 parts, Folium Isatidis 20 ~ 40 parts, Rhizoma Coptidis 15 ~ 30 parts, Radix Scutellariae 10 ~ 25 parts, Radix Asparagi 10 ~ 20 parts.

Preferably, the present invention prevents and treats the herbal composite of chicken bronchitis, be made up of the herbal raw material of following weight portion: Elephantopus scaber L. 22 ~ 30 parts, Caulis Lonicerae 30 ~ 35 parts, Mentholum 28 ~ 38 parts, Herba Paederiae 25 ~ 35 parts, Herba Solani Nigri 15 ~ 20 parts, Rhizoma Arisaematis 12 ~ 18 parts, Herba Houttuyniae 30 ~ 40 parts, the Rhizoma Anemarrhenae 20 ~ 26 parts, Ramulus Cinnamomi 25 ~ 31 parts, orange 18 ~ 23 parts, Bulbus Fritillariae Cirrhosae 13 ~ 16 parts, Folium Eriobotryae 19 ~ 26 parts, Cortex Mori 20 ~ 25 parts, Radix Platycodonis 11 ~ 17 parts, 12 ~ 18 parts, TianXing wood, Bulbus Lilii 10 ~ 16 parts, Radix Panacis Quinquefolii 6 ~ 9 parts, Radix Adenophorae (Radix Glehniae) 8 ~ 12 parts, 12 ~ 18 parts, Semen Armeniacae Amarum, Radix Asteris 18 ~ 25 parts, the Radix Stemonae 25 ~ 30 parts, Pheretima 17 ~ 22 parts, Concha Solen gouldii Siberian cocklebur 28 ~ 35 parts, Radix Isatidis 15 ~ 20 parts, Folium Isatidis 25 ~ 35 parts, Rhizoma Coptidis 18 ~ 26 parts, Radix Scutellariae 13 ~ 18 parts, Radix Asparagi 14 ~ 18 parts.

Preferably, the present invention prevents and treats the herbal composite of chicken bronchitis, be made up of the herbal raw material of following weight portion: Elephantopus scaber L. 26 parts, Caulis Lonicerae 34 parts, Mentholum 32 parts, Herba Paederiae 30 parts, Herba Solani Nigri 18 parts, Rhizoma Arisaematis 15 parts, Herba Houttuyniae 35 parts, the Rhizoma Anemarrhenae 23 parts, Ramulus Cinnamomi 27 parts, orange 20 parts, Bulbus Fritillariae Cirrhosae 15 parts, Folium Eriobotryae 24 parts, Cortex Mori 23 parts, Radix Platycodonis 15 parts, 15 parts, TianXing wood, Bulbus Lilii 13 parts, Radix Panacis Quinquefolii 8 parts, Radix Adenophorae (Radix Glehniae) 10 parts, 15 parts, Semen Armeniacae Amarum, Radix Asteris 21 parts, the Radix Stemonae 28 parts, Pheretima 20 parts, Concha Solen gouldii Siberian cocklebur 32 parts, Radix Isatidis 17 parts, Folium Isatidis 29 parts, Rhizoma Coptidis 20 parts, Radix Scutellariae 15 parts, Radix Asparagi 16 parts.

Present invention also offers the preparation method of the herbal composite of control chicken bronchitis, 28 taste herbal raw materials of the herbal composite of described control chicken bronchitis are put into drug-decocting appliance by proportioning, add the water soaking 1h of 5 ~ 7 times of herbal raw material gross mass, then decoct, first intense fire decocts, after medicinal liquid boiling, use slow fire boiling 1 ~ 1.5h instead to stop, elimination medicinal residues, take concoction, being evaporated to relative density is 1.14 ~ 1.20 (50 DEG C of surveys), centrifugal, extracting centrifugal liquid, conveniently formulation method, add conventional adjuvant and make acceptable dosage form on veterinary drug.

Further, described dosage form is decoction.

Further, the water converting 50kg by 1kg decoction carries out diluting to be drunk to chicken is daily.Decoction after dilution is substituted daily water and drinks to chicken, the effect of control is played to the various epidemic diseases of chicken especially chicken bronchitis.

Present invention also offers the application of herbal composite as feed additive of control chicken bronchitis.

Further, to prevent and treat the feed additive of Chinese medicine composition as chicken feedstuff of chicken bronchitis, chickling is brought into use to delivering for sale after 2 week age, according to Different growth phases, both mix by the ratio being 0.5% ~ 0.8% of daily chicken feeding quality of feeding in the quality of herbal composite, add water after being mixed into compound and make wet feed feeding, the mass ratio of compound and water is 1:0.8 ~ 1.2.The herbal composite that the present invention prevents and treats chicken bronchitis is suitable for feeding chickling, Adult Chicken, laying hen, broiler as chicken feed addictive.This feed additive has promotion chicken digesting and assimilating feedstuff, improves nutritional labeling conversion in vivo, thus promotes growth of meat chicken, can also improve the resistance against diseases of poultry, prevent the generation of various epidemic disease, has significant curative effect to chicken bronchitis control.The present invention adopts wet feed feeding, is not only conducive to digesting and assimilating, and can also cut the waste.

Present invention also offers a kind of Chinese medicine composition preventing and treating chicken bronchitis for the preparation of the application in preventing/treating chicken bronchitis medicine.

In the present invention, the effect of each herbal raw material medicine adopted is as follows:

Elephantopus scaber L.: cold in nature, bitter in the mouth is pungent; Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling, cough-relieving diuresis.For flu, acute tonsillitis, pharyngolaryngitis, eye conjunctivitis, epidemic encephalitis type B, pertussis, acute icterohepatitis, cirrhotic ascites, acute and chronic nephritis, furuncle and phyma, eczema.

Caulis Lonicerae: sweet-bitter flavor, cold nature.Heat-clearing and toxic substances removing, dispelling wind dredging collateral.For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.

Mentholum: acrid in the mouth, cool in nature.There is effect of wind and heat dispersing, the effect preventing bird flu can be played.Cure mainly anemopyretic cold, headache conjunctival congestion, laryngopharynx swelling and pain, toothache, skin pruritus.

Herba Paederiae: sweet in the mouth, micro-hardship, property is put down.There is expelling wind and removing dampness, analgesic antidotal, promoting digestion and removing stagnation, effect of promoting blood circulation and detumescence.For bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall and gastrointestinal angor, dyspepsia, infantile malnutrition, bronchitis; Outer for dermatitis, eczema and sore swollen toxin.

Herba Solani Nigri: there is heat-clearing and toxic substances removing, effect of promoting blood circulation and detumescence.Control furuncle, carbuncle, erysipelas, osteopatia sprain, chronic tracheitis, acute nephritis.For sore and toxic, skin eczema, dysuria, senile chronic tracheitis, leukorrhagia, prostatitis, dysentery.

Rhizoma Arisaematis, containing effective ingredient such as Saponin, benzoic acid, aminoacid, again containing PEARLITOL 25C, has expelling wind to relieve convulsion, effect of drying dampness to eliminate phlegm.

Herba Houttuyniae, acrid in the mouth, cold.There is effect of heat-clearing and toxic substances removing, row's pain detumescence treatment skin ulcer, promoting urination to remove dampness, invigorating the stomach and promoting digestion.For controlling excess-heat, pyretic toxicity, damp, the hot lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. for suffering from of disease.

The Rhizoma Anemarrhenae: bitter in the mouth, cold in nature.Enter lung, stomach, kidney channel.Cure mainly dysphoria with smothery sensation to quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.There is nourishing YIN to lower pathogenic fire, moisturize effect of laxation, can the immunocompetence of enhancing body, control bird flu.

Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, returns urinary bladder channel, heart channel, lung meridian.There is diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, effect of dispersing cold for relieving pain.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Orange: pungent, bitter, temperature.Return lung, spleen channel.There is cold expelling dampness, effect of promoting the circulation of QI expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.Clinical practice proves, has unique curative effect to pulmonary tuberculosis, bronchitis, long-term stomachache, relieving cough and resolving phlegm etc.

Bulbus Fritillariae Cirrhosae: sweet in the mouth, property are flat.Enter lung meridian, stomach warp.There is effect of nourishing the lung to arrest cough, resolving phlegm and relieving asthma, removing heat-phlegm.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Control cough due to consumptive disease, spitting of blood of spitting, ambition Yu Jie, consumptive lung disease, lung abscess, sore throat, acute mastitis.

Folium Eriobotryae: be slightly cold, attaches to the lung and stomach meridians.There is clearing away lung-heat to relieve cough, effect of stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, the treatment of the diseases such as hiccup.

Cortex Mori: sweet in the mouth, pungent, cold in nature.Return lung meridian, spleen channel.There is effect of eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Cure mainly lung-heat and breathe heavily expectorant, diseases caused by retention of fluid stops lung, distension dyspnea with rapid respiration, edema, beriberi, dysuria.

Radix Platycodonis: property is put down, bitter in the mouth, pungent, slightly poisonous, attaches to the lung and stomach meridians.Have eliminate the phlegm, sore-throat relieving, lung qi dispersing, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, the effect such as to foster the spirit of nobility.

TianXing wood: the effect with expelling wind and removing dampness, heat-clearing and toxic substances removing.Cure mainly flu, icterohepatitis, oedema due to nephritis, cough, laryngalgia, keratitis, enteritis, dysentery, acute toothache, swollen ulcer drug, traumatic injury, lumbago and skelalgia.

Bulbus Lilii: the effect with nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Control lung expense chronic cough, cough and spit expectorant blood; After calentura, waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells, beriberi edema.

Radix Panacis Quinquefolii: bitter in the mouth, micro-sweet, cool in nature, has YIN nourishing and QI supplementing, promoting the production of body fluid to quench thirst, effect except irritated, clear asthenic fire, righting gas, resisting fatigue, can the immunocompetence of enhancing body, control bird flu.

Radix Adenophorae (Radix Glehniae): sweet in the mouth, micro-hardship, cold nature, attaches to the lung and stomach meridians.There is clearing away heat and nourishing YIN, effect of nourishing the lung to arrest cough.Cure mainly tracheitis, pertussis, cough due to lung-heat, cough up phlegm yellow thick.

Semen Armeniacae Amarum: bitter in the mouth, slightly warm in nature; Return lung, large intestine channel.There is sending down the abnormal ascending QI relieving cough and asthma, effect of loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.

Radix Asteris: containing effective ingredient such as epifriedelanol, Radix Asteris Saponin, shionone, Quercetins.There is effect of nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm, also have eliminating phlegm and relieving cough effect, antibacterial action, antitumaous effect, can the immunocompetence of enhancing body, control bird flu.Cure mainly that abundant expectoration is breathed with cough, new chronic cough is coughed, chronic cough hemoptysis.

The Radix Stemonae: sweet, bitter, tepor.Return lung meridian.There is nourishing the lung to keep the adverse QI downward cough-relieving, effect of parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendum Pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.

Pheretima: cold in nature, salty in the mouth; Return liver, stomach, lung, urinary bladder channel.There is effect of heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind, Zhichuan, diuresis, dredging collateral eliminating impediment.Cure mainly that high heat is irritated, infantile convulsion is twitched, dyspnea and cough due to lung-heat etc. disease.

Concha Solen gouldii Siberian cocklebur: there is lung heat clearing sending down the abnormal ascending QI, effect of preventing phlegm from forming and stopping coughing.For dyspnea and cough due to lung-heat, sputum mixed with blood, spitting of blood, aphonia, hemorrhoid complicated by anal fistula swells and ache.Lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, bowel relieving disappears hemorrhoid.

Radix Isatidis: the effect with heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving.Cure mainly fever caused by exogenous pathogens, epidemic febrile disease is from the beginning of, laryngopharynx swelling and pain; Maculae caused by violent heat pathogen, mumps, erysipelas, too fat to move sore.

Folium Isatidis: there is heat-clearing and toxic substances removing, effect of cooling blood for hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.

Rhizoma Coptidis: there is heat clearing and damp drying, effect of eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion acid regurgitation, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.

Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, effect of removing toxic substances.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.

Radix Asparagi: sweet in the mouth, hardship, cold in nature; Return lung, kidney channel.There is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire.Quench one's thirst for dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat, dryness of the intestine constipation, diphtheria.It is containing asparagine, B-sitosterol, steroid saponin, the composition such as phlegmatic temperament, furfural derivatives.

In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:

1, herbal composite of the present invention is by 28 taste rich in nutrition content, it is composite that the different Chinese herbal medicine of pharmacodynamic feature carries out science, preparation method overcomes and adopts the simple Chinese medicine pulverized to be added in feedstuff to prevent and treat livestock and poultry, the defect of its Clinical practice DeGrain, and maintain nutritional labeling and the medicinal efficacy of former medicine as much as possible, folk prescription of the present invention not only has heat-clearing and toxic substances removing, expectorant is dried, effect of relieving cough and asthma, also there is YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, nourishing YIN to lower pathogenic fire, moisturize the effects such as laxation, by having complementary functions and Synergistic, thus obtain better effect.The immunocompetence of chicken can be strengthened after application, appetite stimulator, promote growth of meat chicken, improve chicken meat quality.

2, this herbal composite is used to be added in the daily drinking-water of chicken, to occurring that the various symptoms after bronchitis play significant curative effect, no longer there is sneeze in sick chickling, watery nasal discharge, shed tears, swelling of the nose is swollen, stretch neck the symptom such as to dehisce to breathe, and it is energetic, bright plumage, search for food and obviously strengthen, fast growth, this herbal composite visible has obvious antibacterial activity and to bronchial protective effect, good effect is achieved to treatment bronchitis, enhance the immunity of organisms of disease chicken, improve the resistance against diseases of chicken, reduce sickness rate and the case fatality rate of chicken.

3, adopt the mountain path Caulis et Folium Hyptidis suaveolentis chicken that formula of the present invention and method are fed, capon 180 age in days average body weighs 2500 grams, and row chicken 140 age in days average body weighs 1600 grams, and survival rate more than 98%, the nutritional labelings such as inosinic acid significantly improve.The Slaughter of the mountain path Caulis et Folium Hyptidis suaveolentis chicken using chicken feed addictive of the present invention to feed is better, crude protein content is high, moderate fat content, moisture is low, chicken meat quality is high, through Analysis-Test Research Center, Guangxi Zhuang Autonomous Region's sampling inspection, the chicken of output of the present invention is Fresh & Tender in Texture, sweet perfume (or spice) is tasty and refreshing, without fishy smell, nutritious, a kind of high protein, homoamino acid, and it is low in calories, the rational natural animal food of low-fat collocation, the wherein contained necessary imp content of human body reaches 444mg/100g, total amino acid content reaches 21.67%, every the Harmful Residue does not detect, that other high-quality chicken can not be compared, it is the pollution-free food of safety and environmental protection.

4, herbal raw material of the present invention is natural drug, is medicine-food two-purpose food materials, wide material sources, and healthy, green, safety, has no drug resistance, noresidue nontoxic to body.

Detailed description of the invention

Embodiment is below adopted to describe embodiments of the present invention in detail:

The preparation of embodiment 1 herbal composite 1

By Elephantopus scaber L. 26g, Caulis Lonicerae 34g, Mentholum 32g, Herba Paederiae 30g, Herba Solani Nigri 18g, Rhizoma Arisaematis 15g, Herba Houttuyniae 35g, Rhizoma Anemarrhenae 23g, Ramulus Cinnamomi 27g, orange 20g, Bulbus Fritillariae Cirrhosae 15g, Folium Eriobotryae 24g, Cortex Mori 23g, Radix Platycodonis 15g, TianXing wood 15g, Bulbus Lilii 13g, Radix Panacis Quinquefolii 8g, Radix Adenophorae (Radix Glehniae) 10g, Semen Armeniacae Amarum 15g, Radix Asteris 21g, Radix Stemonae 28g, Pheretima 20g, Concha Solen gouldii Siberian cocklebur 32g, Radix Isatidis 17g, Folium Isatidis 29g, Rhizoma Coptidis 20g, Radix Scutellariae 15g, Radix Asparagi 16g totally 28 taste Chinese herbal medicine puts into drug-decocting appliance, add the water soaking 1h of 6 times of herbal raw material gross mass, then decoct, first intense fire decocts, after medicinal liquid boiling, use slow fire boiling 1.5h instead to stop, elimination medicinal residues, take concoction, being evaporated to relative density is 1.16 (50 DEG C of surveys), centrifugal, extracting centrifugal liquid, conveniently formulation method, add conventional adjuvant and make decoction.

The preparation of embodiment 2 herbal composite 2

Elephantopus scaber L. 30g, Caulis Lonicerae 30g, Mentholum 28g, Herba Paederiae 25g, Herba Solani Nigri 20g, Rhizoma Arisaematis 12g, Herba Houttuyniae 30g, Rhizoma Anemarrhenae 26g, Ramulus Cinnamomi 31g, orange 23g, Bulbus Fritillariae Cirrhosae 13g, Folium Eriobotryae 19g, Cortex Mori 20g, Radix Platycodonis 11g, TianXing wood 12g, Bulbus Lilii 16g, Radix Panacis Quinquefolii 6g, Radix Adenophorae (Radix Glehniae) 8g, Semen Armeniacae Amarum 12g, Radix Asteris 25g, Radix Stemonae 30g, Pheretima 22g, Concha Solen gouldii Siberian cocklebur 35g, Radix Isatidis 15g, Folium Isatidis 35g, Rhizoma Coptidis 26g, Radix Scutellariae 13g, Radix Asparagi 14g.Totally 28 taste Chinese herbal medicine put into drug-decocting appliance, add the water soaking 1h of 6 times of herbal raw material gross mass, then decoct, first intense fire decocts, after medicinal liquid boiling, use slow fire boiling 1.5h instead and stop, elimination medicinal residues, take concoction, being evaporated to relative density is 1.20 (50 DEG C of surveys), centrifugal, extracting centrifugal liquid, conveniently formulation method, adds conventional adjuvant and makes decoction.

The preparation of embodiment 3 herbal composite 3

Elephantopus scaber L. 22g, Caulis Lonicerae 35g, Mentholum 38g, Herba Paederiae 35g, Herba Solani Nigri 15g, Rhizoma Arisaematis 18g, Herba Houttuyniae 40g, Rhizoma Anemarrhenae 20g, Ramulus Cinnamomi 25g, orange 18g, Bulbus Fritillariae Cirrhosae 16g, Folium Eriobotryae 26g, Cortex Mori 25g, Radix Platycodonis 17g, TianXing wood 18g, Bulbus Lilii 10g, Radix Panacis Quinquefolii 9g, Radix Adenophorae (Radix Glehniae) 12g, Semen Armeniacae Amarum 18g, Radix Asteris 18g, Radix Stemonae 25g, Pheretima 17g, Concha Solen gouldii Siberian cocklebur 28g, Radix Isatidis 20g, Folium Isatidis 25g, Rhizoma Coptidis 18g, Radix Scutellariae 18g, Radix Asparagi 18g totally 28 taste Chinese herbal medicine puts into drug-decocting appliance, add the water soaking 1h of 5 times of herbal raw material gross mass, then decoct, first intense fire decocts, after medicinal liquid boiling, use slow fire boiling 1h instead to stop, elimination medicinal residues, take concoction, being evaporated to relative density is 1.14 (50 DEG C of surveys), centrifugal, extracting centrifugal liquid, conveniently formulation method, add conventional adjuvant and make decoction.

The preparation of embodiment 4 herbal composite 4

Elephantopus scaber L. 35g, Caulis Lonicerae 25g, Mentholum 45g, Herba Paederiae 40g, Herba Solani Nigri 12g, Rhizoma Arisaematis 10g, Herba Houttuyniae 50g, Rhizoma Anemarrhenae 15g, Ramulus Cinnamomi 22g, orange 15g, Bulbus Fritillariae Cirrhosae 20g, Folium Eriobotryae 30g, Cortex Mori 27g, Radix Platycodonis 8g, TianXing wood 8g, Bulbus Lilii 6g, Radix Panacis Quinquefolii 10g, Radix Adenophorae (Radix Glehniae) 15g, Semen Armeniacae Amarum 10g, Radix Asteris 15g, Radix Stemonae 20g, Pheretima 25g, Concha Solen gouldii Siberian cocklebur 25g, Radix Isatidis 25g, Folium Isatidis 20g, Rhizoma Coptidis 15g, Radix Scutellariae 25g, Radix Asparagi 20g.Totally 28 taste Chinese herbal medicine put into drug-decocting appliance, add the water soaking 1h of 5 times of herbal raw material gross mass, then decoct, first intense fire decocts, after medicinal liquid boiling, use slow fire boiling 1h instead and stop, elimination medicinal residues, take concoction, being evaporated to relative density is 1.14 (50 DEG C of surveys), centrifugal, extracting centrifugal liquid, conveniently formulation method, adds conventional adjuvant and makes decoction.

The preparation of embodiment 5 herbal composite 5

Elephantopus scaber L. 18g, Caulis Lonicerae 40g, Mentholum 20g, Herba Paederiae 20g, Herba Solani Nigri 25g, Rhizoma Arisaematis 10g, Herba Houttuyniae 20g, Rhizoma Anemarrhenae 30g, Ramulus Cinnamomi 36g, orange 25g, Bulbus Fritillariae Cirrhosae 10g, Folium Eriobotryae 12g, Cortex Mori 16g, Radix Platycodonis 20g, TianXing wood 20g, Bulbus Lilii 18g, Radix Panacis Quinquefolii 2g, Radix Adenophorae (Radix Glehniae) 5g, Semen Armeniacae Amarum 20g, Radix Asteris 30g, Radix Stemonae 35g, Pheretima 12g, Concha Solen gouldii Siberian cocklebur 50g, Radix Isatidis 10g, Folium Isatidis 40g, Rhizoma Coptidis 15g, Radix Scutellariae 10g, Radix Asparagi 10g totally 28 taste Chinese herbal medicine puts into drug-decocting appliance, add the water soaking 1h of 6 times of herbal raw material gross mass, then decoct, first intense fire decocts, after medicinal liquid boiling, use slow fire boiling 1.5h instead to stop, elimination medicinal residues, take concoction, being evaporated to relative density is 1.16 (50 DEG C of surveys), centrifugal, extracting centrifugal liquid, conveniently formulation method, add conventional adjuvant and make decoction.

Embodiment 6 Chinese medicine composition is as the application of the feed additive of chicken feedstuff

The feed additive of Chinese medicine composition as chicken feedstuff of chicken bronchitis is prevented and treated in embodiment 1 ~ 5, chickling is brought into use to delivering for sale after 2 week age, 2 ~ 9 week age, both mix by the ratio being 0.5% of daily chicken feeding quality of feeding in the quality of herbal composite, add water and make wet feed feeding after being mixed into compound; 10 ~ 20 week age, both mixed by the ratio being 0.7% of daily chicken feeding quality of feeding in the quality of herbal composite, add water and make wet feed feeding after being mixed into compound; To delivering for sale more than 21 week age, both mix by the ratio being 0.8% of daily chicken feeding quality of feeding in the quality of herbal composite, add water and make wet feed feeding after being mixed into compound, and the mass ratio of compound and water is 1:0.8 ~ 1.2.

Clinical trial

One, long term toxicity test

The production overall process of 300 of the applicant's autotrophy healthy mountain path Caulis et Folium Hyptidis suaveolentis chickens is tested, to delivering for sale after 2 week age of chickling, long term administration, give decoction prepared by embodiment 1, the water converting 35-40kg by 1kg decoction carries out diluting to be drunk to chicken is daily, or give the application of embodiment 6, carry out long term toxicity test, result shows that the indexs such as all test chicken general status, growth promoter, routine blood test, Liver and kidney function are showed no abnormal change, and histopathology and gross necropsy also have no pathological change.Through Analysis-Test Research Center, Guangxi Zhuang Autonomous Region's sampling inspection, and every the Harmful Residue does not detect.

Two, herbal composite of the present invention is to the curative effect of chicken bronchitis

Experimental animal: chickling 250 in 2 week age (being provided by present invention applicant), isolated rearing 10 days, not inoculative infection bronchitis vaccine.Chicken is divided into 5 groups at random, often organizes 50, be respectively matched group 1, matched group 2, matched group 3, test group 1, test group 2.

For prelibation strain: infectious bronchitis strain, is provided by Guangxi veterinary institute.

Test method:

Matched group 1 is normal healthy controls group, only uses routine basis forage feed;

Matched group 2 is counteracting toxic substances matched group, feeds, not administration after counteracting toxic substances with the normal feedstuff identical with normal healthy controls group;

Matched group 3 is fed for the normal feedstuff that normal healthy controls group is identical, and there is chicken bronchitis typical clinical symptom after counteracting toxic substances after, with commercially available Western medicine cough with asthma quick (15mg/ only), moroxydine hydrochloride (10mg/ only), doxycycline (40mg/ only), add 800ml water, freely drink for chicken group after mixing, continuous use 5 days;

Test group 1 normal feedstuff identical with matched group 1, and after counteracting toxic substances, occur chicken bronchitis typical clinical symptom, and by the herbal composite decoction (1.5g/ only) of enforcement 1 gained, add 2.5L water, freely drink for chicken group after mixing, continuous use 5 days;

Test group 2 normal feedstuff identical with matched group 1, and after counteracting toxic substances, there is chicken bronchitis typical clinical symptom, and by the herbal composite decoction (1g/ only) of enforcement 1 gained, add 2L water, freely drink for chicken group after mixing, continuous use 5 days;

Each group of chicken free choice feeding, drinking-water, Routine Management; Observe the symptom of disease chicken every day, dead chicken is weighed, anatomic observation pathological change, and perform itemized record, after testing one week that has carried out, not dead chicken is weighed, dissected, and record pathological changes situation, after having tested, carry out data statistics to test mortality rate, cure rate, effective percentage, concrete outcome is in table 1.

Table 1 herbal composite of the present invention is to the curative effect statistical table of chicken bronchitis

Group	Sick chicken number	Death toll	Cure number	Significant figure	Mortality rate	Cure rate	Effective percentage
								Matched group 1	0	0	-	-	-	-	-
Matched group 2	50	50	-	-	100％	-	-
								Matched group 3	50	8	39	42	16％	78％	84％
Test group 1	50	1	46	49	2％	92％	98％
								Test group 1	50	1	45	48	2％	90％	96％

As can be known from the above table, herbal composite of the present invention is adopted to have significant curative effect to treatment chicken bronchitis.

Model case 1:2014 July, have totally 180 chickling in 3 week age raised in the chicken farm of applicant, originally only have several chickens morbidities, after 2 days, almost there is symptom in various degree in full chicken group.Main manifestations is: disorderly, peel off slow-witted vertical, dyspnea, rhinorrhea, cough, the enlargement of eye face, arranges yellow loose stool to feather pine, sends comparatively obviously hoarse cry night, is diagnosed as infectious bronchitis after diagnosing.First antibiotic and western medicine result are not remarkable, so gavage the Chinese medicine composition decoction embodiment of the present invention 1 described in by every 1g with regard to water to Symptomatic chicken, gavage 5 days continuously, every day 2 times, with regard to water, Chinese medicine composition decoction described in the embodiment of the present invention 1 is gavaged by the amount of every 1.5g to the chicken of serious symptom, gavage 10 days continuously, every day 2 times, finally dead 2, cure 173, cure rate is 96.11%, follows up a case by regular visits to and does not recur so far.

Model case 2:2014 JIUYUE, has the Adult Chicken 50 of raising in the chicken farm of applicant, wherein 12 occur that cough, sneeze, dyspnea, trachea send rale, examine as infectious chicken bronchitis.It is all invalid to start with antibiotic etc., both is mixed, adds water and make wet feed feeding after being mixed into compound, be used in conjunction 3 weeks to all ill Adult Chickens in the ratio that the quality of the herbal composite of embodiment 1 is 0.8% of daily chicken feeding quality of feeding.Final all cure, cure rate is 100%, and it is full-fledged to follow up a case by regular visits to visible chicken, and gloss is vivid, eagle-eyed, very cocky, and does not recur so far.

Claims (9)

1. prevent and treat the herbal composite of chicken bronchitis for one kind, it is characterized in that being made up of the herbal raw material of following weight portion: Elephantopus scaber L. 18 ~ 35 parts, Caulis Lonicerae 25 ~ 40 parts, Mentholum 20 ~ 45 parts, Herba Paederiae 20 ~ 40 parts, Herba Solani Nigri 12 ~ 25 parts, Rhizoma Arisaematis 10 ~ 20 parts, Herba Houttuyniae 20 ~ 50 parts, the Rhizoma Anemarrhenae 15 ~ 30 parts, Ramulus Cinnamomi 22 ~ 36 parts, orange 15 ~ 25 parts, Bulbus Fritillariae Cirrhosae 10 ~ 20 parts, Folium Eriobotryae 12 ~ 30 parts, Cortex Mori 16 ~ 27 parts, Radix Platycodonis 8 ~ 20 parts, 8 ~ 20 parts, TianXing wood, Bulbus Lilii 6 ~ 18 parts, Radix Panacis Quinquefolii 2 ~ 10 parts, Radix Adenophorae (Radix Glehniae) 5 ~ 15 parts, 10 ~ 20 parts, Semen Armeniacae Amarum, Radix Asteris 15 ~ 30 parts, the Radix Stemonae 20 ~ 35 parts, Pheretima 12 ~ 25 parts, Concha Solen gouldii Siberian cocklebur 25 ~ 50 parts, Radix Isatidis 10 ~ 25 parts, Folium Isatidis 20 ~ 40 parts, Rhizoma Coptidis 15 ~ 30 parts, Radix Scutellariae 10 ~ 25 parts, Radix Asparagi 10 ~ 20 parts.

2. a kind of herbal composite preventing and treating chicken bronchitis according to claim 1, it is characterized in that being made up of the herbal raw material of following weight portion: Elephantopus scaber L. 22 ~ 30 parts, Caulis Lonicerae 30 ~ 35 parts, Mentholum 28 ~ 38 parts, Herba Paederiae 25 ~ 35 parts, Herba Solani Nigri 15 ~ 20 parts, Rhizoma Arisaematis 12 ~ 18 parts, Herba Houttuyniae 30 ~ 40 parts, the Rhizoma Anemarrhenae 20 ~ 26 parts, Ramulus Cinnamomi 25 ~ 31 parts, orange 18 ~ 23 parts, Bulbus Fritillariae Cirrhosae 13 ~ 16 parts, Folium Eriobotryae 19 ~ 26 parts, Cortex Mori 20 ~ 25 parts, Radix Platycodonis 11 ~ 17 parts, 12 ~ 18 parts, TianXing wood, Bulbus Lilii 10 ~ 16 parts, Radix Panacis Quinquefolii 6 ~ 9 parts, Radix Adenophorae (Radix Glehniae) 8 ~ 12 parts, 12 ~ 18 parts, Semen Armeniacae Amarum, Radix Asteris 18 ~ 25 parts, the Radix Stemonae 25 ~ 30 parts, Pheretima 17 ~ 22 parts, Concha Solen gouldii Siberian cocklebur 28 ~ 35 parts, Radix Isatidis 15 ~ 20 parts, Folium Isatidis 25 ~ 35 parts, Rhizoma Coptidis 18 ~ 26 parts, Radix Scutellariae 13 ~ 18 parts, Radix Asparagi 14 ~ 18 parts.

3. a kind of herbal composite preventing and treating chicken bronchitis according to claim 1, it is characterized in that being made up of the herbal raw material of following weight portion: Elephantopus scaber L. 26 parts, Caulis Lonicerae 34 parts, Mentholum 32 parts, Herba Paederiae 30 parts, Herba Solani Nigri 18 parts, Rhizoma Arisaematis 15 parts, Herba Houttuyniae 35 parts, the Rhizoma Anemarrhenae 23 parts, Ramulus Cinnamomi 27 parts, orange 20 parts, Bulbus Fritillariae Cirrhosae 15 parts, Folium Eriobotryae 24 parts, Cortex Mori 23 parts, Radix Platycodonis 15 parts, 15 parts, TianXing wood, Bulbus Lilii 13 parts, Radix Panacis Quinquefolii 8 parts, Radix Adenophorae (Radix Glehniae) 10 parts, 15 parts, Semen Armeniacae Amarum, Radix Asteris 21 parts, the Radix Stemonae 28 parts, Pheretima 20 parts, Concha Solen gouldii Siberian cocklebur 32 parts, Radix Isatidis 17 parts, Folium Isatidis 29 parts, Rhizoma Coptidis 20 parts, Radix Scutellariae 15 parts, Radix Asparagi 16 parts.

4. a kind of preparation method of preventing and treating the herbal composite of chicken bronchitis according to claim 1 or 2 or 3, it is characterized in that: 28 taste herbal raw materials of the herbal composite of described treatment chicken bronchitis are put into drug-decocting appliance by proportioning, add the water soaking 1h of 5 ~ 7 times of herbal raw material gross mass, then decoct, first intense fire decocts, after medicinal liquid boiling, use slow fire boiling 1 ~ 1.5h instead to stop, elimination medicinal residues, take concoction, being evaporated to relative density is 1.14 ~ 1.20 (50 DEG C of surveys), centrifugal, extracting centrifugal liquid, conveniently formulation method, add conventional adjuvant and make acceptable dosage form on veterinary drug.

5. a kind of preparation method of preventing and treating the herbal composite of chicken bronchitis according to claim 1 or 2 or 3, is characterized in that: described dosage form is decoction.

6. a kind of preparation method of preventing and treating the herbal composite of chicken bronchitis according to claim 5, is characterized in that: the water converting 35 ~ 40kg by 1kg decoction carries out diluting to be drunk to chicken is daily.

7. a kind of application of herbal composite as feed additive preventing and treating chicken bronchitis according to claim 1 or 2 or 3.

8. a kind of application of herbal composite as feed additive preventing and treating chicken bronchitis according to claim 7, it is characterized in that: to treat the feed additive of Chinese medicine composition as chicken feedstuff of chicken bronchitis, chickling is brought into use to delivering for sale after 2 week age, according to Different growth phases, both mix by the ratio being 0.5% ~ 0.8% of daily chicken feeding quality of feeding in the quality of herbal composite, add water after being mixed into compound and make wet feed feeding, the mass ratio of compound and water is 1:0.8 ~ 1.2.

9. the herbal composite that a kind of according to claim 1 or 2 or 3 prevents and treats chicken bronchitis is for the preparation of the application in preventing/treating chicken bronchitis medicine.