CN102526655B - Stomach-invigorating and parasite-expelling medicine for animals - Google Patents
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Abstract
The invention discloses a stomach-invigorating and parasite-expelling medicine for animals. Various oral preparations are prepared from Tibetan medicine areca-nut, gypsum rubrum, liquorice, atractylodes lancea, dried ginger, Tibet inula, pomegranate, hawthorn, medicated leaven and pterocephalus hookeri by the conventional preparation process for veterinary medicines. The clinical test result shows that the stomach-invigorating and parasite-expelling medicine has the effects of promoting digestion, eliminating stasis, warming middle energizer, dispelling cold, regulating vital energy, invigorating stomach, killing various intestinal parasites of the animals and the like, can be used for treating digestive diseases of the animals caused by various reasons and gastrointestinal type cold and expelling the intestinal parasites in the animals and the like. Under the disease-free condition, the stomach-invigorating and parasite-expelling medicine has the effects of resisting bacterial, promoting growth and the like, can be used for enhancing fat maintenance, fattening and weight increment of flocks and herds in spring and autumn, contributes to increase of slaughter rate and has great significance for reducing grassland pressure, preventing grassland deterioration, relieving grass demand contradiction, maintaining ecological balance of the grassland and promoting virtuous cycle of grassland animal husbandry.
Description
Technical field
The invention belongs to field of veterinary, relate to a kind of medicine for animal stomach invigorating anthelmintic, be mainly used in treating the digestive disease that animal causes because of a variety of causes, common cold of gastrointestinal type and driving is controlled the diseases such as Enterozoa in animal body.
Background technology
Animal husbandry is the pillar industry specialty industries of China Tibetan area, and the sound development of animal husbandry, be directly connected to Tibetan area social stability and the masses of farmers and herdsmen's living standard.Production high-quality, efficient medicine for animals are also supplied farming and pastoral area in time, can effectively improve the veterinary medicament situation in short supply of bringing because of factors such as Tibetan area are remote, traffic is less-developed, make veterinary medicament treat in time livestock disease, reduce the Died Of Disease rate, promote the development of Tibetan area animal husbandry, strengthen peasants and herdsmen's income.In recent years, along with the production-scale continuous expansion of aquaculture, the number of animals raised of domestic animal is surged.Livestock products are subject to for a long time the residual and residual pollution defect of epidemic disease of medicine and day by day show, have become the significant obstacle that affected the Tibetan area animal husbandry development.
In Alpine-arctic Pastoral, usually because of season and temperature Change, the domestic animal gastrointestinal tract happens occasionally, and the spy is standby is that spring and summer replaces season, because domestic animal eats after the frost feedstuff, not only causes gastrointestinal disease, and the secondary other diseases, causes the domestic animal mortality.Epidemiological study shows, the sickness rate of Tibetan area Adult Yak is 23.5%, and mortality rate is 12.5%, and it is slow that disease symptom mainly is glandular stomach, and grainsick, and the secondary other diseases causes dead aggravation, mostly appears at spring and summer, the time when autumn turns into winter, in cold weather.The mortality rate of yak calf is 15.48%, and disease symptom mostly is ascites, after mostly appearing at the calf wean.As can be seen here, gastroenteropathy is one of principal element affected the growth of animal cub, growth and adults health.In addition, the infection of the multiple Enterozoas such as cestode and ascarid, ancylostome is also common disease the most in herds, the normal growth that affects animal and health that it is serious, therefore, developing a kind of safe, inexpensive and curative effect stomach invigorating anthelmintic drug preferably, is technical barrier urgently to be resolved hurrily in current animal husbandry development.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for animal stomach invigorating anthelmintic.
A kind of medicine for animal stomach invigorating anthelmintic of the present invention, be that to take Tibetan medicine Semen Arecae, Mirabilitum crystallina, Radix Glycyrrhizae, Rhizoma Atractylodis, Rhizoma Zingiberis, Radix Inulae, Punica granatum L., Fructus Crataegi, Massa Medicata Fermentata, Herba pterocephali ten flavors be crude drug, the various oral preparations of making by the conventional preparation technology of veterinary drug.
In pharmaceutical formulation of the present invention, Semen Arecae (hiding the ancient territory of name), nature and flavor hardship; Hot; Temperature.Return stomach; Large intestine channel.Effect: expelling intestinal worms and removing food stagnancy; Promoting the circulation of QI to induce diuresis; Cure mainly: 1. anthelmintic: the multiple Enterozoas such as main expelling tenia and ascarid, ancylostome.2. circulation of qi promoting removing food stagnancy: kind stagnation of QI due to dyspepsia distension and the stagnant dysentery stomachache controlled.3. inducing diuresis to remove edema: be suitable for the edema excess syndrome.
Mirabilitum crystallina (hiding the name monarch has a rest), nature and flavor: hot, salty, cold.Gui Jing: the heart, stomach, kidney channel.Effect: resolving heat and reducing pathogenic fire, sharp key, detumescence.There is the effect of toxicity, the strong and property of medicine of being in harmonious proportion.Cure mainly: row calentura while controlling, accumulated heat excessive thirst, vomiting and diarrhoea, edema, urine retention, bleeding from the gum, erysipelas, scald.
Radix Glycyrrhizae (hiding the fragrant A Er of name), nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.Cure mainly: for weakness of the spleen and stomach, laryngopharynx swelling and pain, the extremity contraction is anxious, too fat to move sore, cushion and alimentary toxicosis.
Fructus Crataegi (hiding name office day), nature and flavor: sour in the mouth, sweet, nontoxic, slightly warm in nature.Gui Jing: enter spleen, stomach warp.Effect: appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Cure mainly: for retention of food and drink, long-pending abdominal mass is gathered, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool, lochiorrhea, antibacterially wait effect.
Rhizoma Atractylodis (hiding the name west), nature and flavor: hot, bitter, temperature.Gui Jing: return spleen, stomach, Liver Channel.Effect: drying damp and strengthening spleen, dispel the wind, cold expelling, improving eyesight.Cure mainly: for distension and fullness in the abdomen, have loose bowels, edema, rheumatic arthralgia, anemofrigid cold, nyctalopia nyctalopia.
Radix Inulae (hiding name Ma Na), nature and flavor: hot, bitter, temperature.Gui Jing: return spleen, stomach, gallbladder, tri-jiao channel.Effect: circulation of qi promoting, pain relieving, relieving distension.Cure mainly: for the tripe abdomen pain of stagnation of QI in spleen and stomach, inappetence, abdominal swelling, stomachache, dysentery tenesmus.
Rhizoma Zingiberis (hiding the name loud, high-pitched sound adds), nature and flavor: suffering, heat.Gui Jing: return spleen, stomach, kidney, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, the dampness expectorant.Cure mainly: hinder the water-cooled pain, vomiting is had loose bowels, the cold extremities faint pulse, and phlegm retention is breathed with cough.
Punica granatum L. (hiding name match folding), nature and flavor: sour in the mouth is puckery, warm in nature, nontoxic.Gui Jing: stomach, large intestine channel.Effect: deficiency and coldness chronic diarrhea, the relieving dyspepsia of promoting the production of body fluid.Cure mainly: enteritis, have blood in stool, proctoptosis, removing toxic substances, taeniasis, cooling etc.
Massa Medicata Fermentata (have another name called: Massa Medicata Fermentata, hide name five agates), nature and flavor: sweetness, micro-be with pungent, temperature partially.Gui Jing: enter spleen, stomach warp.Effect: insufficiency of the spleenly do not change promoting digestion and removing stagnation.Cure mainly: the stomachache, diarrhoea, inappetence, the abdominal part that because of insufficiency of the spleen dyspepsia, cause are vexed swollen.
Herba pterocephali (hide the name prescription protects more), nature and flavor: hardship, cold, slightly poisonous.Gui Jing: return stomach, kidney channel.Effect: removing toxic substances removes pestilence, clearing away heat to cure dysentery, and blood stasis dispelling dispels the wind.Cure mainly: be used for the treatment of pestilent toxicity, new and old epidemic febrile disease, dirty onychonosus, pyretic arthralgia disease, dysentery, rheumatic arthritis, intestinal colic etc.
The present invention is combined above-mentioned ten flavors, the drug effect of each crude drug is played altogether, work in coordination with and realize its dyspepsia and intestinal stasis relieving, regulating qi-flowing for strengthening spleen, warming middle-JIAO to dispel cold, the wide intestinal of dispelling the stagnated QI, drive the effect of controlling gastrointestinal nematode parasites, thereby reach the digestive disease that causes because of a variety of causes for the treatment of animal, common cold of gastrointestinal type and drive the diseases such as Enterozoa of controlling in animal body.
Experimental results demonstrate, in medicine of the present invention, each crude drug is filled a prescription in following scope, all can reach dyspepsia and intestinal stasis relieving, warming middle-JIAO to dispel cold, regulating qi-flowing for strengthening spleen, multiple parasitic effect in the animal repelling body:
15～50 parts of Semen Arecaes, 10～35 parts of Mirabilitum crystallinas, 5～35 parts, Radix Glycyrrhizae, 10～35 parts of Rhizoma Atractylodis, 10～50 parts of Rhizoma Zingiberiss, 10～35 parts of Radix Inulae, 10～50 parts of Punica granatum L.s, 15～50 parts of Fructus Crataegis, 9～30 parts of Massa Medicata Fermentata, 13～50 parts of Herba pterocephali.
Optimum ratio is: 20～30 parts of Semen Arecaes, 20～30 parts of Mirabilitum crystallinas, 15～25 parts, Radix Glycyrrhizae, 20～25 parts of Rhizoma Atractylodis, 20～40 parts of Rhizoma Zingiberiss, 20～30 parts of Radix Inulae, 20～40 parts of Punica granatum L.s, 20～35 parts of Fructus Crataegis, 15～20 parts of Massa Medicata Fermentata, 20～35 parts of Herba pterocephali.
Best proportioning is: 30 parts of Semen Arecaes, 15 parts of Mirabilitum crystallinas, 15 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Zingiberiss, 20 parts of Radix Inulae, 15 parts of Punica granatum L.s, 30 parts of Fructus Crataegis, 20 parts of Massa Medicata Fermentata, 30 parts of Herba pterocephali.
Said ratio is weight portion meter all.
Usage: warm water gavages.
Consumption: horse cattle: 105 ~ 250g; Pig sheep: 30 ~ 60g.
Effect below by clinical observation to drug-treated animals dyspepsia and intestinal stasis relieving of the present invention, warming middle-JIAO to dispel cold and animal repelling endoparasite describes.Below the clinical observation on the therapeutic effect statistics for the Tibetan area yak:
1. for laboratory animal and experimental drug
1.1 the selection of model household
Select each 40 of 9 raisers' Adult Yak (3 years old mean age) and the yak calves at 6 monthly ages, totally 80 as model household, carries out the clinical pharmacology effect observation.
1.2 test drug
The powder agent medicine (hiding name: Sai Aijixia ties) of by the present invention, filling a prescription and preparing.
2 test methods
Be divided into four groups for examination composition year yak and yak calf, for each 20 of examination groups, each 20 of matched groups.Gavage not medication of matched group for the examination group.One day twice, 150～250 grams of Adult Bovine, 30～60 grams of yak calf, for three days on end.Adult Yak gavages October, and 6 monthly ages of yak calf gavage, and measures body weight before gavaging simultaneously, and gavage latter 2 months and measure again body weight, and statistics yak body weight situation and survival rate.
3 result of the tests: the statistical result of yak body weight situation and survival rate is in Table 1,2.
Table 1 yak calf body weight gain situation statistical table unit: kilogram)
Table 2 Adult Yak body weight gain situation statistical table: (unit: kilogram)
The statistics of table 1 and table 2 shows, Adult Yak for the examination group than many weightening finish 5.14 kg of matched group, the yak calf for the examination group than many weightening finish 7.35 kg of matched group.Through t check significant difference (P<0.05).Measure the situation of body weight the same period at December for examination composition year yak and matched group Adult Yak, improve 20%～30% average weight gain successful for the examination group because of efficiency of feed utilization, some individuality of matched group has the phenomenon of losing flesh, because of December in hay season, efficiency of feed utilization is poor, causes and loses flesh.
Table 3,4 is respectively the statistics that the sheep effect is put in yak calf and Adult Yak field in a suitable place to breed: test drug and test method are the same.
Statistical effect is put in table 3 yak calf field in a suitable place to breed
Statistical effect is put in table 4 Adult Yak field in a suitable place to breed
Table 3,4 statistics show, after taking stomach invigorating anthelmintic drug of the present invention for the examination group, greatly reduce the generation of gastroenteropathy, thereby greatly reduce the mortality rate of Adult Yak, have improved the survival rate of yak calf.
In sum, stomach invigorating anthelmintic drug of the present invention has dyspepsia and intestinal stasis relieving, the warming middle-JIAO effects such as multiple parasite of dispeling cold, regulate the flow of vital energy in stomach invigorating and kill animals intestinal, can be used for treating the digestive disease that animal causes because of a variety of causes, common cold of gastrointestinal type and driving is controlled the diseases such as Enterozoa in animal body.In anosis situation, there is the effects such as antibiotic guarantor's growth promotion, can be used to strengthen the spring and autumn cattle and sheep the bodyguard, fatten, increase weight, be conducive to increase the number of heads of livestock for sale, to alleviating grassland pressure, prevent deterioration of grasslands, alleviating grass needs contradiction, keep the Grassland balance, the benign cycle tool that promotes grassland agriculture is of great significance.In addition, crude drug of the present invention relies on the abundant Tibetan herb resource in Tibetan area, its cheapness, high-quality, safety, reliable, and stable curative effect, have very large development potentiality.
The specific embodiment
Preparation below by specific embodiment to medicine of the present invention is described further.
The preparation of embodiment 1, powder agent medicine
Formula: in weight portion
30 parts of Semen Arecaes, 15 parts of Mirabilitum crystallinas, 15 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Zingiberiss, 20 parts of Radix Inulae, 15 parts of Punica granatum L.s, 30 parts of Fructus Crataegis, 20 parts of Massa Medicata Fermentata, 30 parts of Herba pterocephali.
Technique: by the common process preparation of preparation animal powder agent medicine.
The preparation of embodiment 2, granules medicine
Formula: in weight portion
15 parts of Semen Arecaes, 10 parts of Mirabilitum crystallinas, 5 parts, Radix Glycyrrhizae, 10 parts of Rhizoma Atractylodis, 10 parts of Rhizoma Zingiberiss, 35 parts of Radix Inulae, 50 parts of Punica granatum L.s, 50 parts of Fructus Crataegis, 30 parts of Massa Medicata Fermentata, 50 parts of Herba pterocephali.
Technique: by the common process preparation of preparation animal granules medicine.
The preparation of embodiment 3, capsule medicine
Formula: in weight portion
50 parts of Semen Arecaes, 35 parts of Mirabilitum crystallinas, 35 parts, Radix Glycyrrhizae, 35 parts of Rhizoma Atractylodis, 50 parts of Rhizoma Zingiberiss, 10 parts of Radix Inulae, 10 parts of Punica granatum L.s, 15 parts of Fructus Crataegis, 9 parts of Massa Medicata Fermentata, 13 parts of Herba pterocephali.
Technique: by the common process preparation of preparation animal capsule medicine.
The preparation of embodiment 4, pill medicine
Formula: in weight portion
15 parts of Semen Arecaes, 10 parts of Mirabilitum crystallinas, 5 parts, Radix Glycyrrhizae, 10 parts of Rhizoma Atractylodis, 10 parts of Rhizoma Zingiberiss, 10 parts of Radix Inulae, 10 parts of Punica granatum L.s, 15 parts of Fructus Crataegis, 9 parts of Massa Medicata Fermentata, 13 parts of Herba pterocephali.
Technique: by the common process preparation of preparation animal pill medicine.
The preparation of embodiment 5, oral solutions medicine
Formula: in weight portion
50 parts of Semen Arecaes, 35 parts of Mirabilitum crystallinas, 35 parts, Radix Glycyrrhizae, 35 parts of Rhizoma Atractylodis, 50 parts of Rhizoma Zingiberiss, 35 parts of Radix Inulae, 50 parts of Punica granatum L.s, 50 parts of Fructus Crataegis, 30 parts of Massa Medicata Fermentata, 50 parts of Herba pterocephali.
Technique: by the common process preparation of preparation animal oral solutions medicine.
Claims (3)
1. the medicine for animal stomach invigorating anthelmintic is the oral preparations that the crude drug by following weight portion is prepared from:
15～50 parts of Semen Arecaes, 10～35 parts of Mirabilitum crystallinas, 5～35 parts, Radix Glycyrrhizae, 10～35 parts of Rhizoma Atractylodis, 10～50 parts of Rhizoma Zingiberiss, 10～35 parts of Radix Inulae, 10～50 parts of Punica granatum L.s, 15～50 parts of Fructus Crataegis, 9～30 parts of Massa Medicata Fermentata, 13～50 parts of Herba pterocephali.
2. as claimed in claim 1 for the medicine of animal stomach invigorating anthelmintic, it is characterized in that: the weight proportion of described each crude drug is:
20～30 parts of Semen Arecaes, 20～30 parts of Mirabilitum crystallinas, 15～25 parts, Radix Glycyrrhizae, 20～25 parts of Rhizoma Atractylodis, 20～40 parts of Rhizoma Zingiberiss, 20～30 parts of Radix Inulae, 20～40 parts of Punica granatum L.s, 20～35 parts of Fructus Crataegis, 15～20 parts of Massa Medicata Fermentata, 20～35 parts of Herba pterocephali.
3. as claimed in claim 1 for the medicine of animal stomach invigorating anthelmintic, it is characterized in that: the weight proportion of described each crude drug is:
30 parts of Semen Arecaes, 15 parts of Mirabilitum crystallinas, 15 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Atractylodis, 20 parts of Rhizoma Zingiberiss, 20 parts of Radix Inulae, 15 parts of Punica granatum L.s, 30 parts of Fructus Crataegis, 20 parts of Massa Medicata Fermentata, 30 parts of Herba pterocephali.
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| CN103417870A (en) * | 2013-09-04 | 2013-12-04 | 周冠旻 | Drug used for expelling pig parasites |
| CN105616808A (en) * | 2014-10-27 | 2016-06-01 | 河南惠通天下生物工程有限公司 | Traditional Chinese veterinary drug with effects of stomach invigorating and deworming, and preparation method thereof |
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