CN102526525B - Traditional Chinese medicine composition for treating transmissible gastroenteritis of swine - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating transmissible gastroenteritis of swine, comprising the following materials: scutellaria baicalensis, folium isatidis, elecampane, bamboo shavings, potentilla chinensis, dandelion, plantain seed, rhizoma alismatis, smoked plum, medicine terminalia fruit, astragalus mongholicus, rhizoma atractylodis alba, colla corii asini and liquorice. The adopted traditional Chinese medicine composition has the advantages of obvious curative effect for treating swine with the transmissible gastroenteritis of swine, treatment for both principal and secondary aspects of disease, effects for strengthening body resistance and eliminating evil, comprehensive adjustment, balance for yin and yang, high healing rate, no toxic and side effects, difficult recurrence, no medicine injury and low cost and the like.

Description

A kind of Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine

Technical field

The present invention relates to the herbal medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.

Background technology

Transmissible gastroenteritis of swine is the distinctive acute alimentary infection disease of a boar that is caused by RNA type coronavirus, this disease morbidity is anxious, propagate fast, the pig at various ages only all can infect, to cause that 7～10 ages in days are vomitted, seriously suffered from diarrhoea with interior piglet and high mortality is feature, but along with the growth in age pig year, the pig mortality rate more than 5 ages in week is very low.Primary disease has taken place and has determined that its cause of disease is coronavirus in the U.S. in reported first in 1945 in Doyle and Hutchings.Japan in 1956, nineteen fifty-seven, primary disease took place in Britain in succession, and primary disease has become a kind of global pig infectious disease at present.TGE[3 was found in Taiwan first in 1958], be separated to first in the China's Mainland in 1973 transmissible gastro-enteritis virus (Transmissible gastroenteritis virus of swine, TGEV).Up to now, the most of provinces and cities of China have primary disease to take place.

Transmissible gastroenteritis of swine is divided into dissimilar intestinal inflammation such as mucus, suppurative, hemorrhagic, gangrenosum acne, fiber disposition by the inflammation type; Be divided into constitutional and secondary enteritis by the cause of disease; By course of disease process, acute and chronic branch is arranged again.With diarrhoea, dehydration, it is feature that idol has stomachache, acid base imbalance in various degree clinically.Disease just is the symptom of acute bowel gastric catarrh more, occurs the classical symptom of following gastroenteritis later on gradually or rapidly.

Sick pig, all have transmissible gastro-enteritis virus with the gas of feces, vomitus, milk, nasal discharge and the exhalation of malicious pig and rehabilitation pig etc., can pollute feedstuff, drinking-water, air etc., but mainly infect by respiratory tract, secondly be digestive tract, primary disease takes place at the beginning of last month of spring in winter and is popular, be generally incubation period 15～18 hours, long reaches 2～3 days.

At present, all adopt vaccine virus immunization to prevent both at home and abroad, domestic veterinary work person with the urgent prophylactic immunization of vaccine of amount at double, receives reasonable effect usually when epidemic situation is broken out.But, carry out immunity and produced certain effect though use vaccine clinically, also there is rebound phenomenon.

Yet the life-time service antibiotic not only can destroy original microbiota in the animal alimentary canal, influences the normal development of animal, also easily causes problems such as drug residue, drug resistance, drug contamination, and prevention effect is also unsatisfactory.

In recent years, herbal medicine is to be used for animal diseases control under unique Chinese veterinarian's theoretical direction, have nutrition and medicinal double effects concurrently, compare with Western medicine and have natural sex, versatility, low toxicity pair, be difficult for producing advantages such as hazard residue and drug resistance, be the animal wide clinical application.But, at present, being used for the treatment of the Chinese herbal medicine of transmissible gastroenteritis of swine and important compound preparation and having that prescription is not smart, kind is single, therapeutic effect is also not satisfactory.

Summary of the invention

Technical problem to be solved by this invention is to be to provide a kind of novel Chinese medicine composition of transmissible gastroenteritis of swine and preparation method thereof that is used for the treatment of, treatment has evident in efficacy to transmissible gastroenteritis of swine to adopt this Chinese medicine composition, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, the cure rate height has no side effect, be difficult for recurrence, no poisoning has no drug resistance, low cost and other advantages.

Ask in order to solve above-mentioned technology, the invention provides a kind of Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, it comprises: Radix Scutellariae, Folium Isatidis, the Radix Aucklandiae, Caulis Bambusae In Taenia, Herba Potentillae Chinensis, Herba Taraxaci, Semen Plantaginis, Rhizoma Alismatis, Fructus Mume, Fructus Chebulae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Colla Corii Asini and Radix Glycyrrhizae.

Wherein, the ratio of weight and number of each component in the described Chinese medicine composition is Radix Scutellariae 50～60 weight portions, Folium Isatidis 23～27 weight portions, the Radix Aucklandiae 10～12 weight portions, Caulis Bambusae In Taenia 12～15 weight portions, Herba Potentillae Chinensis 15～17 weight portions, Herba Taraxaci 16～18 weight portions, Semen Plantaginis 11～13 weight portions, Rhizoma Alismatis 8～10 weight portions, Fructus Mume 12～14 weight portions, Fructus Chebulae's 8～9 weight portions, the Radix Astragali 17～20 weight portions, the Rhizoma Atractylodis Macrocephalae 15～17 weight portions, Colla Corii Asini 10～12 weight portions and Radix Glycyrrhizae 7～9 weight portions.

Wherein, can also comprise Fructus Ligustri Lucidi in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, the ratio of weight and number of described Fructus Ligustri Lucidi in described Chinese medicine composition is Fructus Ligustri Lucidi 2～4 weight portions.

Wherein, can also comprise Fructus Crataegi and Massa Medicata Fermentata in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, described Fructus Crataegi and the Massa Medicata Fermentata ratio of weight and number in described Chinese medicine composition is Fructus Crataegi 3～6 weight portions, Massa Medicata Fermentata 2～4 weight portions.

Wherein, can also comprise Fructus Citri Sarcodactylis and Pericarpium Citri Reticulatae in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, described Fructus Citri Sarcodactylis and the Pericarpium Citri Reticulatae ratio of weight and number in described Chinese medicine composition is Fructus Citri Sarcodactylis 1～4 weight portion, Pericarpium Citri Reticulatae 3～7 weight portions

Wherein, described Chinese medicine composition pharmaceutical dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.

For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine composition that is used for the treatment of the animal transmissible gastroenteritis of swine, and described Chinese medicine composition is prepared from by the following method:

The first step is also pulverized each component by described mixed;

Second step added immersion and decoction in the distilled water with the mixture after the pulverizing of first step acquisition, merged decoction liquor and was concentrated into thick shape;

In the 3rd step, the thick liquid matter that second step was obtained adds ethanol, and fully stirring and evenly mixing precipitates, and filters, and obtains first alcoholic solution;

In the 4th step, first alcoholic solution that the 3rd step was obtained adds the abundant stirring and evenly mixing of ethanol again, and precipitation is filtered, and obtains second alcoholic solution;

The 5th step was concentrated into nothing alcohol flavor to second alcoholic solution that obtains, and adding distil water cold preservation precipitation is filtered, and filtrate is concentrated, and drying is pulverized, and obtains 50 orders～100 purpose graininess Chinese medicine composition of the present invention.

For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and it comprises:

The first step is also pulverized each component by described mixed;

Second step added immersion and decoction in the distilled water with the mixture after the pulverizing of first step acquisition, merged decoction liquor and was concentrated into thick shape;

In the 3rd step, the thick liquid matter that second step was obtained adds ethanol, and fully stirring and evenly mixing precipitates, and filters, and obtains first alcoholic solution;

In the 4th step, first alcoholic solution that the 3rd step was obtained adds the abundant stirring and evenly mixing of ethanol again, and precipitation is filtered, and obtains second alcoholic solution;

The 5th step was concentrated into nothing alcohol flavor to second alcoholic solution that obtains, and adding distil water cold preservation precipitation is filtered, and filtrate is concentrated, and drying is pulverized, and obtains 50 orders～100 purpose graininess Chinese medicine composition of the present invention.

For solving the problems of the technologies described above, the present invention also provides a kind of fodder compound, and it comprises: as above-mentioned Chinese medicine composition and the feed vector of additive.

For solving the problems of the technologies described above, the present invention also provides above-mentioned Chinese medicine composition for the preparation of the application in the medicine for the treatment of transmissible gastroenteritis of swine.

Beneficial effect of the present invention:

With respect to the medicine that is used for the treatment of transmissible gastroenteritis of swine of the prior art, adopt this Chinese medicine composition to have evident in efficacy to the treatment of the pig that suffers from transmissible gastroenteritis of swine, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, across-the-board regulation, Yin Yang balancing, the cure rate height has no side effect, and is difficult for recurrence, no poisoning, low cost and other advantages.

The specific embodiment

The clinical symptoms of transmissible gastroenteritis of swine is: primary disease incubation period is 12 hours～18 hours, piglet vomits suddenly, then draining sample yellow green feces, be mixed with white indigested ziega and bubble, flavor is stench, sick temperature of pig body short-term raises, extremely thirsty, obviously dehydration, body weight descends rapidly, and is dead in 2～7 days after the morbidity of being everlasting.The pig symptom weight of growing up differs, general one to a couple of days poor appetite or stop eating, feces is thin in water, is spurting, includes bubble, very stench, indivedual pigs vomit.Diarrhoea stopped and rehabilitation in 5～8 days, and death seldom.The sow that has the lactogenic minimizing can occur or stop, and generally recovers through 3～7 days.

The pathological change of transmissible gastroenteritis of swine is: corpse is become thin, and dehydration obviously; Be full of ziega in the stomach, gastric mucosa mild hyperaemia and hemorrhage; Enteral is full of white or yellow-green liquid and bubble, the small bowel attenuation, and the small intestinal mucosa Villus atrophy shortens, and the mucosal epithelium cytopathy, comes off, and elasticity reduces, the dilatation of intestine shape that is translucent, mesenteric adenophyma expands, tangent plane succulence and redly; Kidney has muddy swelling and steatosis, and contains the adularescent urate.

Chinese herbal medicine is the powerful mean of motherland's medical science disease preventing and treating, traditional Chinese veterinary medicine is cured the disease, from " organic conception " and " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", viewpoint according to " treatment must aim at the pathogenesis of disease ", propose base therapy principles such as " strengthening vital QI to eliminate pathogenic factors ", " strengthening the body resistance ", overcome the undue shortcoming that mechanically, singlely acts on some links of Western medicine.Studies have shown that some Chinese herbal medicine has the viricidal effect of pressing down, but most of Chinese herbal medicine is to bring into play its antivirus action by regulating immunity of organisms, its mechanism of action comprises: 1. regulate immunity by acting on hypothalamus-hypophysis-adrenal cortex axle; 2. by adjusting the vegetative nerve regulating immunity; 3. regulate immunity by acting on nucleolus adenosine (CAMP/ CGMP) system; 4. regulate immunity by adjusting nucleic acid metabolism; 5. regulate immunity by improving T cell quantity and function; 6. regulate immunity by the dual regulation of medicine and prescription itself.

Theory of Chinese medical science thinks that transmissible gastro-enteritis virus property disease is the heresy of epidemic disease, belongs to the pestilence category, and from the dialectical theory of Chinese veterinarian: Chinese veterinarian's Coryza Treated by Syndrome Differentiation is main method for the treatment of with dampness, heat clearing away.Damp is gone, and taste are waken up, and the merit of fortuneization is recovered; The pathogenic heat solution, intestinal is clear, secretes the normal restoration of gastrointestinal function of pure and impure function.

According to above-mentioned theory and principle, the invention provides a kind of like this Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, it comprises: Radix Scutellariae, Folium Isatidis, the Radix Aucklandiae, Caulis Bambusae In Taenia, Herba Potentillae Chinensis, Herba Taraxaci, Semen Plantaginis, Rhizoma Alismatis, Fructus Mume, Fructus Chebulae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Colla Corii Asini and Radix Glycyrrhizae.

Radix Scutellariae: bitter in the mouth, cold in nature, go into the heart, lung, stomach, gallbladder, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, antiabortive, the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.That Radix Scutellariae has is analgesic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppress effect such as intestinal tube wriggling, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, bacillus pyocyaneus are had certain inhibitory action, upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc. are had curative effect preferably.

Folium Isatidis: bitter in the mouth, property Great Cold go into the heart, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, the effect of jaundice eliminating, excess-heat that can the clearing heat in QI system branch can be separated the pyretic toxicity of blood system again, is mainly used in the hyperpyrexia sweating due to the pestilence calentura, the excessive thirst taking fluids profusely; The speckle of sending out that fire-toxin is flourishing is gone mad symptoms such as haematemesis; The unconsciousness due to high fever of measles, the rash color is purple dark; Dampness-heat in the liver and gallbladder is accumulate the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; Symptoms such as the pharyngalgia due to the fire stagnation pyretic toxicity, aphtha of the mouth and tongue, hepatitis, Folium Isatidis can strengthen leukocytic phagocytic activity, and various bacteria is had stronger inhibitory action, and the effect of function of gallbladder promoting and reduction capillary permeability is still arranged.

The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, go into spleen, stomach, large intestine, gallbladder meridian, the effect of week pain relieving is arranged, all gas of energy lifting, it is stagnant to be longer than capable the intestines and stomach again, leads the heap soil or fertilizer over and around the roots of three warmers; The card of all mechanism of qi retardances as the intestines and stomach stagnation of QI, is gone up and to be vomiting, in be distension and fullness in the abdomen, down for having loose bowels, also can be used for the damp and hot stagnant dysentery of the intestines and stomach, symptoms such as tenesmus have inhibitory action to Bacillus typhi, bacillus subtilis, dysentery bacterium.

The Radix Aucklandiae stomach of being amusing, consumer product dredge stasis, promoting the circulation of QI to relieve pain are used in conjunction with Radix Scutellariae, can rush down damp and hot, reason gastrointestinal, treat hygropyretic dysentery, tenesmus.

Caulis Bambusae In Taenia: sweet in the mouth, cold nature is gone into lung, stomach warp, the effect that removing heat-phlegm is arranged, relieves restlessness and prevents vomiting, being mainly used in lung meridian has heat, the cough ant phlegm of expectorant and accumulation of heat; The gallbladder fire is held expectorant under the arm, violates lung and disturbs the vexed of the heart, the palpitation with fear insomnia; Middle wind-phlegm fan, insufficiency of stomach is held the cards such as vomiting of heat under the arm.

It is not peaceful that Radix Scutellariae and Caulis Bambusae In Taenia two medicines share the unhappiness that can treat heat-phlegm pent-up, and gastropyretic vomiting.

Herba Potentillae Chinensis: bitter in the mouth, cold in nature, return liver, large intestine channel has heat clearing and damp drying, and the effect of eliminating pathogenic heat from blood to cure dysentery is used for damp-heat dysentery, has loose bowels, cards such as dysentery, stomachache, acute bacterial are understood, heat in blood is hemorrhage, spit blood, have blood in stool, hematuria, metrorrhagia.

Herba Taraxaci: sweet in the mouth, bitter, cold in nature, go into liver, the stomach warp, has heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, the effect of inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to the acute mastitis effect, also can be used for the treatment of the symptoms such as conjunctival congestion and swelling pain of flaming up of liver-fire, in addition, the effect that also has promoting urination to remove dampness, be used for controlling jaundice due to damp-heat; dysuria; treatment of conditions such as urinary system infection, common reply Staphyloccocus aureus; escherichia coli; bacillus pyocyaneus; shigella flexneri; paratyphoid fever; white beads Niu Jun; cattle type Brucella has certain bacteriostasis; To Trichophyton concentricunm, permitted haze achorion, the little sporeformer of rust, Gypsum Fibrosum sample budlet spore tinea bacterium etc. bacteriostasis all arranged.

Semen Plantaginis: sweet in the mouth, cold in nature, go into liver, kidney, small intestinal, lung, urinary bladder channel, clearing away heat and promoting diuresis is arranged, expelling phlegm for arresting cough, the effect that makes eye bright, the cough that is mainly used in wind-heat invading the lung is spat; The conjunctival congestion and swelling pain of liver-fire rising; Damp and hot accumulateing in the dysuria of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, accumulation of heat in the urinary bladder, cards such as jaundice due to damp-heat.

Rhizoma Alismatis: sweet in the mouth, light, cold in nature, go into kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen, purging heat and treating stranguria are arranged, the lung that clears away heart-fire, rush down the effect of kidney fire, be mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The heresy of diseases caused by retention of fluid phlegm-damp is stranded resistance, causes dizzy that the clear YANG failing to ascend voiced sound does not fall; The dysuria of damp invasion of lower energizer, the puckery pain of red weak point, and card such as jaundice due to damp-heat have inhibitory action to tubercule bacillus, the two ball coccuses of pneumonia, staphylococcus aureus etc.

Fructus Mume: bitter in the mouth, acid, puckery, warm in nature, go into liver, lung, spleen, large intestine channel, have and astringe the lung, astringing intestine to stop diarrhea, hemostasis, the effect of promoting the production of body fluid, it is more than to be used for the treatment of chronic dysentery, damp-heat dysentery is had blood in stool, card such as hematuria, snowslide, and is inhibited to multiple pathogenic bacterias such as dysentery bacterium, escherichia coli, Bacillus typhi.

The Fructus Chebulae: bitter in the mouth, acid, puckery, property is flat, goes into lung, stomach, large intestine channel, and the effect of convergence astringing intestine to stop diarrhea and the therapeutic method to keep the adverse QI flowing downwards of astringing the lung is arranged, and is mainly used in insufficiency of the spleen chronic diarrhea chronic dysentery; The proctoptosis of sinking of QI of middle-JIAO; The phlegmatic cough of breathing with cough; Cards such as chronic cough aphonia, the Fructus Chebulae all has inhibitory action to various dysentery bacteriums, effect to bacillus pyocyaneus, diphtheria corynebacterium is stronger, and staphylococcus aureus, escherichia coli, streptococcus pneumoniae, Hemolytic streptococcus, Bacillus proteus, bacillus typhi murium are also had inhibitory action.. " medicine justice ": the Fructus Chebulae can fall and can receive, and gets both that it is kind, covers golden sky and then rings, and to be that pathogenic fire is strongly fragrant hold back lung qi, so that shout to breath with cough and cough, or to celostomia, astringe the lung with this pathogenic fire reducing, and then the lung key does not have and is jammed, and sound is limpid.Get its astringents being suitable for treating collapsesyndrome, if the chronic diarrhea chronic dysentery, then excess pathogen goes and first QI prostration, and with this medicine with spleen invigorating, astringent or styptic treatment for spontaneous sweating large intestine, dysentery is from ending.But hardship can be lost heart, and vital qi great void person should use it less.

The Radix Astragali: sweet in the mouth, warm in nature, go into spleen, lung meridian, tonification spleen soil is arranged, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effects such as holder skin ulcer granulation promoting are mainly used in the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, cards such as insufficiency of vital energy and blood.The Radix Astragali strengthens the heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, the effect that protects the liver with blood sugar lowering is arranged, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had inhibitory action.But the conduction of Radix Astragali appreciable impact splenocyte information realizes immunoregulation effect.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, go into spleen, stomach warp, the spleen reinforcing promoting the circulation of QI is arranged, the dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, the QI failing to transform into body fluid, the phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; Cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had regulating action.

Colla Corii Asini: sweet in the mouth, property are flat, go into lung, liver, kidney channel, and tonifying blood and arresting bleeding is arranged, and nourshing Yin and drynsessmoistening prescription effect can be used for the shallow complexion of various asthenia symptom, especially blood deficiency, and thin and weak weak, the head is dizzy, palpitation and insomnia; Malnutritional anemia, thrombocytopenic purpura; Deficient property hemoptysis; The haematemesis hematuria is had blood in stool; The cough dry pharynx of lung-dryness syndrome due to deficiency of YIN, sputum mixed with blood; Symptoms such as the spasm of muscles and vessels of pathogenic heat lingering, deficiency of YIN blood consumption, stirring-up of pathogenic wind in the interior resulting from deficiency, tetany, Colla Corii Asini has the erythrocytic generation of promotion, increases blood calcium concentration, promotes the effect of hemostasis, and helps to strengthen the immunologic function of animal.

Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.

The present invention is with heat-clearing and toxic substances removing, air making-up and spleen enlivening is the Therapeutic Principle, use Radix Scutellariae, Folium Isatidis, the Radix Aucklandiae, Caulis Bambusae In Taenia, Herba Potentillae Chinensis, Herba Taraxaci, heat-clearing and toxic substances removing, with the Radix Astragali and Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening to regulate body's immunity, strengthen the pathogen of resisting virus, play the effect of eliminating dampness by diuresis spleen invigorating with Semen Plantaginis and Rhizoma Alismatis, use Colla Corii Asini nourishing blood, the immunocompetence of enhancing body is inspired gastric qi with Radix Puerariae, clearing away heat and promoting production of body fluid, thereby play the effect of relieving diarrhea with astringents by adding Fructus Mume and Fructus Mume, can play QI invigorating neutralization with Radix Glycyrrhizae, be in harmonious proportion the effect of each component, all medicines are harmonious, mutually easily clear, transmissible gastroenteritis of swine is had good treatment curative effect.

Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.

In the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, the ratio of weight and number of various components can be preferably: Radix Scutellariae 45～60 weight portions, Folium Isatidis 20～27 weight portions, the Radix Aucklandiae 8～12 weight portions, Caulis Bambusae In Taenia 10～15 weight portions, Herba Potentillae Chinensis 12～17 weight portions, Herba Taraxaci 15～18 weight portions, Semen Plantaginis 9～13 weight portions, Rhizoma Alismatis 7～10 weight portions, Fructus Mume 10～14 weight portions, Fructus Chebulae's 6～9 weight portions, the Radix Astragali 15～20 weight portions, the Rhizoma Atractylodis Macrocephalae 13～17 weight portions, Colla Corii Asini 8～12 weight portions and Radix Glycyrrhizae 5～9 weight portions.

In the described Chinese medicine composition that is used for the treatment of the animal transmissible gastroenteritis of swine, the ratio of weight and number of various components also can be more preferably: Radix Scutellariae 50～60 weight portions, Folium Isatidis 23～27 weight portions, the Radix Aucklandiae 10～12 weight portions, Caulis Bambusae In Taenia 12～15 weight portions, Herba Potentillae Chinensis 15～17 weight portions, Herba Taraxaci 16～18 weight portions, Semen Plantaginis 11～13 weight portions, Rhizoma Alismatis 8～10 weight portions, Fructus Mume 12～14 weight portions, Fructus Chebulae's 8～9 weight portions, the Radix Astragali 17～20 weight portions, the Rhizoma Atractylodis Macrocephalae 15～17 weight portions, Colla Corii Asini 10～12 weight portions and Radix Glycyrrhizae 7～9 weight portions.

Can also comprise Fructus Ligustri Lucidi in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, go into liver, kidney channel, strong liver kidney tonifying is arranged, the effect of clearing away heat to improve acuity of vision is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, symptoms such as interior-heat caused by deficiency of YIN.Fructus Ligustri Lucidi energy promoting leucocytes, the effect of raise immunity has stronger inhibitory action to staphylococcus aureus, dysentery bacterium.

Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.

The ratio of weight and number of described Fructus Ligustri Lucidi in described Chinese medicine composition is Fructus Ligustri Lucidi 2～4 weight portions, more preferably 3～4 weight portions.

For promoting ill pig to eliminate eating accumulation, facilitating digestion absorbs, and can also comprise Fructus Crataegi and Massa Medicata Fermentata in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.

Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature is gone into spleen, stomach, Liver Channel, is used for promoting digestion and invigorating the stomach, and the circulation of qi promoting dissipating blood stasis is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus etc. had the obvious suppression effect.

Massa Medicata Fermentata sweet in the mouth, suffering, warm in nature, go into spleen, the stomach warp has digestion-promoting spleen-invigorating, reduces phlegm, effect such as blood-activating analgetic.Be mainly used in dyspepsia and do not change, distension and fullness in the abdomen, symptoms such as lack of appetite diarrhoea, the phlegm syndrome due to mistake is good for to spleen fortune, and blood stasis pain has certain curative effect.

By adding these two kinds of auxiliary elements of Fructus Crataegi and Massa Medicata Fermentata, can eliminate eating accumulation and advance digestion, increase enterogastric peristalsis, in case distension and fullness in the abdomen, lack of appetite, dysentery, have and regulate the flow of vital energy, stomach function regulating, the effect of spleen invigorating makes pig feed desire to heighten, improve resistance against diseases and immunologic function, reduce disease incidence rate, play a role in health care, thus the treatment transmissible gastroenteritis of swine.

Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.

Described Fructus Crataegi and the Massa Medicata Fermentata ratio of weight and number in described Chinese medicine composition is Fructus Crataegi 3～6 weight portions, Massa Medicata Fermentata 2～4 weight portions.

For promoting ill pig dissipating depression of QI eliminating stagnation, depressed liver-energy dispersing and QI regulating, lowering the adverse-rising QI to subdue asthma, can also comprise Fructus Citri Sarcodactylis and Pericarpium Citri Reticulatae in the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine.

Fructus Citri Sarcodactylis: acrid in the mouth, hardship, warm in nature, return liver, stomach, lung meridian, be used for soothing the liver circulation of qi promoting and in reduce phlegm, be used for the distending pain in the chest and hypochondrium of stagnation of QI due to depression of the liver, incoordination between the liver and stomach, stagnation of QI in spleen and stomach, vomiting and nausea lack of appetite.

Pericarpium Citri Reticulatae: acrid in the mouth, hardship, warm in nature, go into spleen, lung meridian, regulating qi-flowing for strengthening spleen is arranged, the effect of drying dampness to eliminate phlegm is mainly used in stagnation of QI in spleen and stomach, the distension and fullness in the abdomen due to the turbid damp obstructing in middle-JIAO, nausea and vomiting, lack of appetite is indigestion and loss of appetite, and cold syndrome of the stomach QI rising in reverse order or stomach have the vomiting of deficiency-heat card such as to eat less.

Further preferred, the described Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine only is made of said components.

Described Pericarpium Citri Reticulatae and the Radix Aucklandiae ratio of weight and number in described Chinese medicine composition is Fructus Citri Sarcodactylis 1～4 weight portion, Pericarpium Citri Reticulatae 3～7 weight portions.

The present invention also provides the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of transmissible gastroenteritis of swine, and it comprises:

The first step is also pulverized each component by described mixed;

Second step added immersion and decoction in the distilled water with the mixture after the pulverizing of first step acquisition, merged decoction liquor and was concentrated into thick shape;

In the 3rd step, the thick liquid matter that second step was obtained adds ethanol, and fully stirring and evenly mixing precipitates, and filters, and obtains first alcoholic solution;

In the 4th step, first alcoholic solution that the 3rd step was obtained adds the abundant stirring and evenly mixing of ethanol again, and precipitation is filtered, and obtains second alcoholic solution;

The 5th step was concentrated into nothing alcohol flavor to second alcoholic solution that obtains, and adding distil water cold preservation precipitation is filtered, and filtrate is concentrated, and drying is pulverized, and obtains 50 orders～100 purpose graininess Chinese medicine composition of the present invention.

In described second step, the weight of the distilled water of adding is 3～5 times of weight of the mixture that obtains of the first step, and decocting time is 1 hour～2 hours, and decocting number of times is 2～4 times.

In described the 3rd step, adding concentration is 90%～95% ethanol, transfers in the mixture of thick liquid matter and ethanol formation, and determining alcohol is 60%～70%, and the sedimentation time is 36 hours～48 hours.

In described the 4th step, adding concentration again is 90%～95% ethanol, and transferring to determining alcohol is 75%～80%, and the sedimentation time is 24 hours～36 hours.

Sedimentation time in described the 5th step is 24 hours～36 hours, and the amount of the distilled water of adding is 2 times～3 times of the mixture of each component formation, and the filtrate of acquisition can also be prepared into any dosage form as required except being prepared into graininess.

Described Chinese medicine composition pharmaceutical dosage form can all can adopt conventional preparation method to obtain for decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.

The administering mode of described Chinese medicine composition is oral or injection.

The present invention also provides the using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition is put into the water dissolving, stirred the acquisition oral liquid, gavage subsequently to the pig that suffers from transmissible gastroenteritis of swine, gavage 5 days continuously～7 days.

The crude drug concentration of described oral liquid is preferably 1.5g/ml～3g/ml.

The present invention also provides the another kind of using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition is mixed stirring mutually with feed vector, and subsequently with the ill pig of this stirred mixture feeding, continuous 2 week～3 weeks of feeding.

The present invention also provides a kind of fodder compound, comprises above-mentioned Chinese medicine composition additive and feed vector in the said composition.

Described feed vector is preferably one or more in corn, Semen Tritici aestivi, the Fructus Hordei Vulgaris etc.

The ratio of weight and number of described feed vector and described Chinese medicine composition additive can be 100 weight portions: 0.5～1.5 weight portion, more preferably 100 weight portions: 1～1.5 weight portion.

Can also comprise in the described fodder compound that hemicellulase, colloid, ammonium sulfate, sodium carbonate, sodium bicarbonate, carrageenan and maltodextrin are as the additive except Chinese medicine composition.

Feed vector with respect to 100 weight portions, the ratio of weight and number of each other additive component is in the described fodder compound: described hemicellulase is preferably 1～3 weight portion, colloid is preferably 1～3 weight portion, ammonium sulfate is preferably 3～5 weight portions, sodium carbonate is preferably 1～3 weight portion, sodium bicarbonate is preferably 1～3 weight portion, and carrageenan is preferably 3～5 weight portions, and maltodextrin is preferably 3～5 weight portions.

Described colloid preferred water soluble polysaccharide, more preferably one or more mixture in xanthan gum, tamarind gum, carrageenin, pectin, alginic acid, the agar.

The present invention also provides the preparation method of above-mentioned fodder compound, and it comprises:

The first step prepares the described Chinese medicine composition as additive;

Second step, in described ratio with feed vector and and prepared Chinese medicine composition additive pulverize, add water and mix, whipping temp maintains 30～40 ℃, mixing time is 40～60 minutes, wherein, with respect to the feed vector of 100 weight portions, the amount of the water that adds is preferably 35～50 weight portions;

The 3rd step, the material that obtains in second step is put into the steam manipulator carry out pre-gelatinizing, in this step, the temperature in the steam manipulator is preferably 75 ℃～80 ℃, and at this moment, the starch burn degree of feedstuff is 60～70%;

The 4th step, the 3rd material that goes on foot pre-gelatinizing is carried out steam in extruder boil and push, in this step, described extruder can be single-screw extrusion machine or twin (double) screw extruder, temperature in the extruder is preferably 105～115 ℃, pressure is adjusted to 0.7MPa～1.6MPa, and at this moment, the starch burn degree of feedstuff is 95～98%;

The 5th step is with the described fodder compound of the dry acquisition of the material that obtains in the 4th step.

In the preparation method of described fodder compound, can also earlier described enzymatic compositions and described feed vector fully be mixed in described ratio in second step, add water, under preferred 30～40 ℃ temperature, stir, after preferred 30～50 minutes, add described Chinese medicine composition additive, remain on and continue under 30～40 ℃ the temperature to stir 20～40 minutes, further add other additives such as hemicellulase, colloid, ammonium sulfate, sodium carbonate, sodium bicarbonate, carrageenan and maltodextrin subsequently in described ratio and further stirred 10～20 minutes.

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.

The toxicity test of embodiment 1 Chinese medicine composition of the present invention

Trial drug

50g Radix Scutellariae, 23g Folium Isatidis, the 10g Radix Aucklandiae, 12g Caulis Bambusae In Taenia, 15g Herba Potentillae Chinensis, 16g Herba Taraxaci, 11g Semen Plantaginis, 8g Rhizoma Alismatis, 12g Fructus Mume, 8g Fructus Chebulae, the 17g Radix Astragali, the 15g Rhizoma Atractylodis Macrocephalae, 10g Colla Corii Asini, 7g Radix Glycyrrhizae, 2g Fructus Ligustri Lucidi, 3g Fructus Crataegi, 2g Massa Medicata Fermentata, 1g Fructus Citri Sarcodactylis and 3g Pericarpium Citri Reticulatae are mixed and pulverizing; With soaking in the mixture adding 700g distilled water after pulverizing and decocting 3 times, decocted 1.5 hours at every turn, merge decoction liquor and also be concentrated into thick shape; Add concentration subsequently and be 95% ethanol, abundant stirring and evenly mixing, transferring to pure content is 65%, precipitate 36 hours, filtration obtains first alcoholic solution; It is 95% the abundant stirring and evenly mixing of ethanol that first alcoholic solution is added concentration again, and transferring to pure content is 75%, precipitates 36 hours, filters, and obtains second alcoholic solution; Second alcoholic solution that obtains is concentrated into nothing alcohol flavor, adds 500g distilled water cold preservation precipitation 24 hours, filter, filtrate concentrates, and drying is pulverized, obtain 100 purpose graininess Chinese medicine composition of the present invention, described Chinese medicine composition is put into the water dissolving, stirred acquisition oral liquid, crude drug amount 3g/ml.

Get 40 of ICR mices, body weight is at 25～30 grams, by the body weight random packet, 10 every group, male and female half and half, the oral administration solution administration, dosage be respectively 0.8ml/ only, 2ml/ only, 4ml/ only and 8ml/ only.Observed 20 days continuously after the administration, all mices are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, and not seeing has irritative response and other untoward reaction.

Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.

The preparation of embodiment 3 Chinese medicine compositions 1

50g Radix Scutellariae, 23g Folium Isatidis, the 10g Radix Aucklandiae, 12g Caulis Bambusae In Taenia, 15g Herba Potentillae Chinensis, 16g Herba Taraxaci, 11g Semen Plantaginis, 8g Rhizoma Alismatis, 12g Fructus Mume, 8g Fructus Chebulae, the 17g Radix Astragali, the 15g Rhizoma Atractylodis Macrocephalae, 10g Colla Corii Asini and 7g Radix Glycyrrhizae are mixed and pulverizing; With soaking in the mixture adding 650g distilled water after pulverizing and decocting 3 times, decocted 1.5 hours at every turn, merge decoction liquor and also be concentrated into thick shape; Add concentration subsequently and be 95% ethanol, abundant stirring and evenly mixing, transferring to pure content is 65%, precipitate 36 hours, filtration obtains first alcoholic solution; It is 95% the abundant stirring and evenly mixing of ethanol that first alcoholic solution is added concentration again, and transferring to pure content is 75%, precipitates 36 hours, filters, and obtains second alcoholic solution; Second alcoholic solution that obtains is concentrated into nothing alcohol flavor, add 500g distilled water cold preservation precipitation 24 hours, filter, filtrate concentrates, drying is pulverized, and obtains 70 purpose graininess Chinese medicine composition 1 of the present invention, described Chinese medicine composition 1 is put into the water dissolving, stirred acquisition oral liquid, crude drug amount 1.5g/ml.

The preparation of embodiment 4 Chinese medicine compositions 2

60g Radix Scutellariae, 27g Folium Isatidis, the 12g Radix Aucklandiae, 15g Caulis Bambusae In Taenia, 17g Herba Potentillae Chinensis, 18g Herba Taraxaci, 13g Semen Plantaginis, 10g Rhizoma Alismatis, 14g Fructus Mume, 9g Fructus Chebulae, the 20g Radix Astragali, the 17g Rhizoma Atractylodis Macrocephalae, 12g Colla Corii Asini, 9g Radix Glycyrrhizae, 4g Fructus Ligustri Lucidi, 6g Fructus Crataegi, 4g Massa Medicata Fermentata, 4g Fructus Citri Sarcodactylis and 7g Pericarpium Citri Reticulatae are mixed and pulverizing; With soaking in the mixture adding 850g distilled water after pulverizing and decocting 3 times, decocted 1.5 hours at every turn, merge decoction liquor and also be concentrated into thick shape; Add concentration subsequently and be 95% ethanol, abundant stirring and evenly mixing, transferring to pure content is 65%, precipitate 36 hours, filtration obtains first alcoholic solution; It is 95% the abundant stirring and evenly mixing of ethanol that first alcoholic solution is added concentration again, and transferring to pure content is 75%, precipitates 36 hours, filters, and obtains second alcoholic solution; Second alcoholic solution that obtains is concentrated into nothing alcohol flavor, adds 600g distilled water cold preservation precipitation 24 hours, filter, filtrate concentrates, and drying is pulverized, obtain 100 purpose graininess Chinese medicine composition of the present invention, described Chinese medicine composition is put into the water dissolving, stirred acquisition oral liquid, crude drug amount 3g/ml.

The preparation of embodiment 5 fodder compounds 1

Chinese medicine composition 1 additive of 10kg wheatfeed carrier and 0.1kg embodiment 3 preparations is pulverized, is added 3.5kg water and mixes, whipping temp maintains 40 ℃, mixing time is 60 minutes, the material that obtains is put into the steam manipulator and is carried out pre-gelatinizing, temperature in the steam manipulator is 80 ℃, at this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The described fodder compound 1 of the dry acquisition of the material that obtains.

The preparation of embodiment 6 fodder compounds 2

Chinese medicine composition 2 additives of 10kg wheatfeed carrier and 0.15kg embodiment 4 preparations are pulverized, are added 3.5kg water and mix, whipping temp maintains 40 ℃, mixing time is 60 minutes, the material that obtains is put into the steam manipulator and is carried out pre-gelatinizing, temperature in the steam manipulator is 80 ℃, at this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The described fodder compound 2 of the dry acquisition of the material that obtains.

Embodiment 7:

150 of piglets are introduced on Xingtai City Chi Xian pig farm, Hebei province, there are 35 feces to occur and be yellow green, be canescence individually, be spurting diarrhoea, the time vomiting arranged, lethargy, happiness is crouched, greedy drink, 39～41 ℃ of body temperature, the symptom that tongue Bai Houhuang is greasy, wherein 12 symptoms are heavier, examine to be transmissible gastroenteritis of swine.Just not remarkable with antibiotic and western medicine result, so all pigs are gavaged the embodiment of the invention 4 described Chinese medicine compositions 2 by the amount of 2g/ml, gavage 5 days continuously, every day 2 times, final dead 18, cures 132, cure rate is 88%, follows up a case by regular visits to so far to recur.

Clinical experiment

1.1 for the examination material

1.1.1 for the examination animal

500 of 6 age in days barren sows (pig farm, Tangshan City, Hebei province), male and female half and half, be divided into 5 groups, every group 100, namely organize I: the blank group, group II: counteracting toxic substances matched group, group III: Western medicine amantadine treatment group, the Chinese medicine composition 2 (3g/ml) of the Chinese medicine composition 1 (1.5g/ml) of group IV: embodiment 3, group V: embodiment 4.

1.1.2 for the prelibation strain

The transmissible gastroenteritis of swine strain is provided by Hua Zhong Agriculture University.

1.1.3 medicine

With the Chinese medicine composition 1 (1.5g/ml) of embodiment 3 acquisitions, the Chinese medicine composition 2 (3g/ml) that embodiment 4 obtains, amantadine is provided by Zhejiang Province's health body Pharmaceutical, is made into the oral liquid that crude drug concentration is 0. 2 mg/ml.

1.2 test method

500 healthy piglets are divided into five groups at random, group I is the normal healthy controls group, group II is the counteracting toxic substances matched group, group III is the western medicine group that gavages the oral liquid of Western medicine hydrochloric acid norfloxacin, and group IV and group V are the treatment by Chinese herbs group of oral liquid that gavages the Chinese medicine composition 2 of the oral liquid of Chinese medicine composition 1 of embodiment 3 and embodiment 4; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease pig symptom every day when 9:00 and 16:00, dead pig is only weighed, the anatomic observation pathological change, and perform itemized record, dead pig only weighed, dissects in seven days to having tested, and record pathological changes situation, after test is finished, test mortality rate, cure rate, effective percentage are carried out data statistics, and concrete outcome sees Table 1.

Table 1

?	Sick pig number	Death toll	Cure number	Significant figure	Mortality rate %	Cure rate %	Effective percentage %
								Group I	0	0	-	-	0	-	-
Group II	100	100	-	-	100%	-	-
								Group III	100	27	69	73	27%	69%	73%
The group IV	100	15	82	85	15%	82%	85%
								The group V	100	12	86	88	12%	86%	88%

In this experimentation, allly at duration of test the symptom of transmissible gastroenteritis of swine and dead appears, the ill apparition person of necropsy, be judged to infect dead.

Effectively after medication, Si Wang pig only is not effectively, and the percentage rate that every group of survival pig number accounts for the test pig number is effective percentage, and recovery from illness is after medication, and it is normal that the mental status, appetite etc. are recovered, and all belongs to recovery from illness, and the percentage rate that recovery from illness pig number accounts for the test pig number is cure rate.

From table 1, we adopt Chinese medicine composition of the present invention that transmissible gastroenteritis of swine is had significant curative effect as can be seen.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims (5)

1. Chinese medicine composition that is used for the treatment of transmissible gastroenteritis of swine, it is characterized in that: described Chinese medicine composition only is made of Radix Scutellariae, Folium Isatidis, the Radix Aucklandiae, Caulis Bambusae In Taenia, Herba Potentillae Chinensis, Herba Taraxaci, Semen Plantaginis, Rhizoma Alismatis, Fructus Mume, Fructus Chebulae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Colla Corii Asini and Radix Glycyrrhizae;

The parts by weight of each component in the described Chinese medicine composition are Radix Scutellariae 50～60 weight portions, Folium Isatidis 23～27 weight portions, the Radix Aucklandiae 10～12 weight portions, Caulis Bambusae In Taenia 12～15 weight portions, Herba Potentillae Chinensis 15～17 weight portions, Herba Taraxaci 16～18 weight portions, Semen Plantaginis 11～13 weight portions, Rhizoma Alismatis 8～10 weight portions, Fructus Mume 12～14 weight portions, Fructus Chebulae's 8～9 weight portions, the Radix Astragali 17～20 weight portions, the Rhizoma Atractylodis Macrocephalae 15～17 weight portions, Colla Corii Asini 10～12 weight portions and Radix Glycyrrhizae 7～9 weight portions.

2. Chinese medicine composition as claimed in claim 1 is characterized in that: described Chinese medicine composition pharmaceutical dosage form is decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.

3. the described Chinese medicine composition that is used for the treatment of the animal transmissible gastroenteritis of swine of claim 1 is characterized in that described Chinese medicine composition is prepared from by the following method:

The first step is also pulverized each component by described mixed;

Second step added immersion and decoction in the distilled water with the mixture after the pulverizing of first step acquisition, merged decoction liquor and was concentrated into thick shape;

In the 3rd step, the thick liquid matter that second step was obtained adds ethanol, and fully stirring and evenly mixing precipitates, and filters, and obtains first alcoholic solution;

In the 4th step, first alcoholic solution that the 3rd step was obtained adds the abundant stirring and evenly mixing of ethanol again, and precipitation is filtered, and obtains second alcoholic solution;

The 5th step was concentrated into nothing alcohol flavor to second alcoholic solution that obtains, and adding distil water cold preservation precipitation is filtered, and filtrate is concentrated, and drying is pulverized, and obtains 50 orders～granular Chinese medicine composition of 100 purposes.

4. the preparation method of the described Chinese medicine composition of claim 1 is characterized in that, comprising:

The first step is also pulverized each component by described mixed;

Second step added immersion and decoction in the distilled water with the mixture after the pulverizing of first step acquisition, merged decoction liquor and was concentrated into thick shape;

In the 3rd step, the thick liquid matter that second step was obtained adds ethanol, and fully stirring and evenly mixing precipitates, and filters, and obtains first alcoholic solution;

In the 4th step, first alcoholic solution that the 3rd step was obtained adds the abundant stirring and evenly mixing of ethanol again, and precipitation is filtered, and obtains second alcoholic solution;

The 5th step was concentrated into nothing alcohol flavor to second alcoholic solution that obtains, and adding distil water cold preservation precipitation is filtered, and filtrate is concentrated, and drying is pulverized, and obtains 50 orders～granular Chinese medicine composition of 100 purposes.

5. a fodder compound is characterized in that, comprising: as the described Chinese medicine composition of the claim 1 of additive and feed vector.