CN102488848B - Traditional Chinese medicine composition used for treating high-pathogenicity porcine reproductive and respiratory syndrome, preparation method thereof, and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition used for preventing and treating high-pathogenicity porcine reproductive and respiratory syndrome (PPRS). The composition comprises common anemarrhena, gypsum, snakegourd root, common lophatherum herb, reed rhizome, honeysuckle flower, Baikal skullcap root, red peony root, lanceolate dichotomous starwort root, ligusticum, sanna leaf, pilose asiabell root, and Mongolian milkvetch root. According to the invention, when the high-pathogenicity PPRS is treated by using the traditional Chinese medicine composition, the medicine composition is advantaged in substantial treatment effect, high curative rate, no toxic or side-effect, low reoccurrence rate, no drug induced suffering, and low cost. With the traditional Chinese medicine composition, both root causes and symptoms can be treated, and the meat quality satisfies a standard of commodity inspections.

Description

Chinese medicine composition, the preparation method and application for the treatment of highly pathogenic PRRS

Technical field

The present invention relates to the herbal medicine technical field, relate in particular to a kind of Chinese medicine composition for prevention and treatment highly pathogenic PRRS.

Background technology

It is a major industry of China's animal husbandry development that ecological pig produces, it also is a main pillar of China's livestock products foreign exchange earning, be aspect increasing national income and uplifting the people's living standard, accelerate Development of farming and animal husbandry, the important goal of the aspects such as adjustment agriculture industrialization structure.

" highly pathogenic PRRS " claims again " hyperpyrexia disease ", by pig breeding and breathing syndrome poison variant the high lethal epidemic disease of a kind of polarity that causes to be arranged, after nineteen ninety-five is imported China into, caused larger popular several times in China, especially since 2006, " highly pathogenic PRRS " that reproductive and respiratory syndrome variation strain causes (claiming again " hyperpyrexia disease ") occurs with popular in the south China area, then most of hog area affects the whole country rapidly, its oncoming force is violent, lose big, historical rare, cause tens thousand of pig death, economic loss is huge, numerous medium and small enterprise so breaks of raising pigs.

" highly pathogenic PRRS " is immunosuppressive disease, swinery infects this after being ill, and the main infringement of virus macrophage can damage collective's immune function, cause the immunosuppressant of pig, cause Slow immunological response, make very easily supervention various diseases of disease pig, this disease has the characteristics of " three-hypers one is low ", be that fever, sickness rate are high, mortality rate is high, cure rate is low, most of morbidity pig farm sickness rate is more than 50%, and mortality rate is up to 50%～90%, and prevention and treatment are all very difficult.

" highly pathogenic PRRS " is a kind of height contagious disease, ill pig and be the main source of infection of this disease with malicious pig, main route of transmission is that contact infection, air borne and seminal fluid are propagated, also can pass through the Placenta Hominis vertical transmission, but the number of ways such as susceptible pig direct oral cavity, nasal cavity, muscle, vein and intrauterine inoculation and infect virus, and pig infect after the virus 2～14 weeks can be by contact with viral communication to other susceptible pigs.

The cardinal symptom of suffering from the pig of " highly pathogenic PRRS " has: body temperature obviously raises, and sickness rate is high, skin rubefaction, and later stage limb end, the inferior place of abdomen are blue; The inflammation of eye conjunctiva, blepharoedema; Cough, asthma, dyspnea, the later stage is ventral breathing; Part pig rear quarters is unable, can not stand or occur the nervous symptoms such as ataxia; Stool is normal or have loose bowels, or does and rarely alternately indivedual pig intractable diarrheas are arranged also, the urine jaundice, and the later stage is brownish red; Sow miscarriage occurs, produces stillborn fetus, weak tire or mummy tire.

At present, the mode of " highly pathogenic PRRS " many employings vaccine injection is prevented and is treated, common are the disinfectant such as aldehydes, chlorine-containing disinfectant, phenols, oxidant, compound iodine preparation, bases kills the virus of this disease or adopts the injection such as antiviral interferon, penicillin, spectinomycin, oxytetracycline to treat this disease, it is slow that but vaccine produces immunity, and keep the immunity time short, toxic and side effects is large, and existing Chinese medicine preparation effect is undesirable, treatment is slow, the course for the treatment of is long, and cure rate is low.

Summary of the invention

Technical problem to be solved by this invention is to be to provide a kind of novel Chinese medicine composition that is used for prevention and treatment highly pathogenic PRRS and preparation method thereof, adopt this Chinese medicine composition to have evident in efficacy to prevention and the treatment of the pig that suffers from highly pathogenic PRRS, treating both the principal and secondary aspects of a disease, cure rate is high, have no side effect, be difficult for recurrence, without poisoning, cost is low, and meat is without the advantages such as melancholy of commodity inspection.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for prevention and treatment highly pathogenic PRRS, it comprises: the Rhizoma Anemarrhenae, Gypsum Fibrosum, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae, Radix Angelicae Sinensis, Folium Sennae, Radix Codonopsis and the Radix Astragali.

Wherein, the ratio of weight and number of each component in the described Chinese medicine composition is the described Rhizoma Anemarrhenae 50～60 weight portions, described Gypsum Fibrosum 30～35 weight portions, described Radix Trichosanthis 15～20 weight portions, described Herba Lophatheri 15～20 weight portions, described Rhizoma Phragmitis 15～20 weight portions, described Flos Lonicerae 10～15 weight portions, described Radix Scutellariae 20～25 weight portions, described Radix Paeoniae Rubra 10～15 weight portions, described Radix Stellariae 10～15 weight portions, described Radix Angelicae Sinensis 20～25 weight portions, described Folium Sennae 10～15 weight portions, described Radix Codonopsis 20～25 weight portions and the described Radix Astragali 20～25 weight portions.

Wherein, can also comprise Semen Cuscutae in the described Chinese medicine composition that is used for the treatment of highly pathogenic PRRS, the ratio of weight and number of described Semen Cuscutae in described Chinese medicine composition is Semen Cuscutae 10～20 weight portions.

Wherein, can also comprise Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus in the described Chinese medicine composition that is used for the treatment of highly pathogenic PRRS, described Fructus Crataegi, Pericarpium Citri Reticulatae Viride, the ratio of weight and number of Fructus Oryzae Germinatus in described Chinese medicine composition are Fructus Crataegi 3～5 weight portions, Pericarpium Citri Reticulatae Viride 3～5 weight portions and Fructus Oryzae Germinatus 3～5 weight portions.

Wherein, can also comprise Radix Glycyrrhizae in the described Chinese medicine composition that is used for the treatment of highly pathogenic PRRS, the ratio of weight and number of described Radix Glycyrrhizae in described Chinese medicine composition is Radix Glycyrrhizae 5～10 weight portions.

Wherein, can also comprise Colla Corii Asini in the described Chinese medicine composition that is used for the treatment of highly pathogenic PRRS, the ratio of weight and number of described Colla Corii Asini in described Chinese medicine composition is Colla Corii Asini 5～10 weight portions.

For solving the problems of the technologies described above, the present invention also provides a kind of Chinese medicine composition that is used for the treatment of highly pathogenic PRRS, and described Chinese medicine composition is prepared from by the following method:

The first step is packed the Rhizoma Anemarrhenae in the multi-function extractor into, adds alcohol heating reflux and extracts, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, obtain extractum, with the extractum stored refrigerated, enter subsequently in the spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes;

Second step is pulverized Gypsum Fibrosum, decocts with water 2～4 times, merges decoction liquor, filters, and static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is dried to dried cream except anhydrating, and pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders;

The 3rd step, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae and Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder;

The 4th step decocted with water Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali respectively 2～4 times, merged decoction liquor separately, filtered, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder;

In the 5th step, with being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition.

For solving the problems of the technologies described above, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, and it comprises:

The first step is packed the Rhizoma Anemarrhenae in the multi-function extractor into, adds alcohol heating reflux and extracts, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, obtain extractum, with the extractum stored refrigerated, enter subsequently in the spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes;

Second step is pulverized Gypsum Fibrosum, decocts with water 2～4 times, merges decoction liquor, filters, and static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is dried to dried cream except anhydrating, and pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders;

The 3rd step, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae and Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder;

The 4th step decocted with water Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali respectively 2～4 times, merged decoction liquor separately, filtered, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder;

In the 5th step, with being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition.

For solving the problems of the technologies described above, the present invention also provides a kind of fodder compound, and it comprises: comprise above-mentioned Chinese medicine composition and feed vector as additive.

Wherein, can also comprise in the described fodder compound that hemicellulase, colloid, ammonium sulfate, sodium carbonate, sodium bicarbonate, carrageenan and maltodextrin are as the additive except Chinese medicine composition.

For solving the problems of the technologies described above, the present invention also provides above-mentioned Chinese medicine composition for the preparation of the application in the medicine of prevention and treatment highly pathogenic PRRS.

Beneficial effect of the present invention:

With respect to the medicine for prevention and treatment highly pathogenic PRRS of the prior art, the present invention adopts this Chinese medicine composition to have evident in efficacy to prevention and the treatment of highly pathogenic PRRS, treating both the principal and secondary aspects of a disease, cure rate is high, have no side effect, be difficult for recurrence, without poisoning, cost is low, and meat is without the advantages such as melancholy of commodity inspection.

The specific embodiment

Chinese veterinarian's theory thinks that " highly pathogenic PRRS " belongs to Epidemic Febrile Disease, is that gas heat is flourishing, damp and hot accumulate long-pending, in force blood system, pyretic toxicity enters to defend to be abandoned due to the nutrient blood, and causes the time of intense heat in both QI and blood systems, and pathogenic fire is for suffering from, with regard to concrete symptom: on the burning hot inflammation, then the eye conjunctiva is rubescent, and eye discharge increases; Pathogenic heat are invaded edema caused by disorder of QI, high heat then, and extreme thirst, skin is scorching hot; Pyretic toxicity is invaded pericardium, disturbs and the mind, and is then drowsiness, and spirit is depressed.Along with the state of an illness is goed deep into accumulateing in the pyretic toxicity, the invasion and attack blood system skin rubefaction then occurs blue, and pore is hemorrhage, the symptom of the bleeding due to blood-heaies such as skin many places purpura.

The pathogeny of highly pathogenic PRRS is: lymphsystem, the cardiac function that pig infects that body's immunity after the virus weakens or pig is poisoned in forfeiture, toxin descend, allow pig lose rejection ability and homergy, continue to infect the meeting of body maker for other antigens, cause of flaccid muscles, female animal miscarriage, raising livestock exclusively for meat production proctoptosis, gastrointestinal, endocrine, maladjusted nervous system, cell tissue amine discharges to be increased, and immunocyte, phagocytic function descend, and can't drain after the death.Cause body at full capacity, most of drug use has increased burden to organism metabolism, accelerates dead.

According to above-mentioned theory, the invention provides a kind of like this Chinese medicine composition for prevention and treatment highly pathogenic PRRS, it comprises: the Rhizoma Anemarrhenae, Gypsum Fibrosum, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae, Radix Angelicae Sinensis, Folium Sennae, Radix Codonopsis and the Radix Astragali.

The Rhizoma Anemarrhenae: be plant amedica, bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, the relieving restlessness of purging heat is arranged, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, the property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, the intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, the xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.

Radix Trichosanthis: i.e. Radix Trichosanthis, sweet in the mouth, little hardship, property acid, cold enters lung, stomach warp, and clearing away heat and promoting production of body fluid is arranged, moistening the lung and resolving the phlegm, the effect of detumescence and apocenosis is mainly used in the excessive thirst of consumption of body fluid caused by febrile disease, diabetes, cough caused by dryness-heat, the symptoms such as carbuncle sore tumefacting virus.

The Rhizoma Anemarrhenae and Radix Trichosanthis are united use can the lung heat clearing sthenia gastropyrexia and promoting the production of body fluid to quench thirst, treats the symptoms such as dry mouth and tougue of consumption of body fluid caused by febrile disease, the treatment diabetes.

Rhizoma Phragmitis: sweet in the mouth, cold in nature, enter lung, stomach warp, the lung heat clearing gastric heat is arranged, diuresis, the dissipating depression of QI clearing away phlegm, the effect of YIN nourishing and the production of body fluid promoting is mainly used in treating the dysphoria with smothery sensation that epidemic febrile disease joins the army minute thirsty, and dryness of the tongue Tianjin is few; The rash of measles goes out not saturating, and pathogenic heat is violated the cough and expectoration of lung; The cough vomiting pus of lung abscess; The damp and hot symptoms such as vomiting singultus that block in stomach.

The sweet cold light weight of Rhizoma Phragmitis, the heat of kind lung heat clearing stomach and hold concurrently thoroughly loosely, treatment fever caused by exogenous pathogenic factors initial stage exterior syndrome, the hot excessive thirst of height in mid-term, the later stage the moon of bringing down a fever of holding concurrently is hindered excessive thirst.

Gypsum Fibrosum: acrid in the mouth, sweet, property Great Cold, enter lung, the stomach warp, clearing away heat-fire is arranged, the quench the thirst effect of relieving restlessness, its abnormal smells from the patient is all thin and matter heavy, the excess-heat of energy removing summer-heat stomach of foot Yang Ming, filling the air for the treatment of pathogen invading YANG MING is high hot, profuse sweating, thirsty, vexed, the symptoms such as arteries and veins flood, key medicine for the bright stomach warp of sun, to epidemic encephalitis, encephalitis b, high heat due to the pneumonia etc. has preferably antipyretic effect, and have relieving convulsion effect concurrently, also can be used for the burning pain in the epigastrium due to the high Sheng of stomach-fire, headache, aphtha of the mouth and tongue and heat-damp in summer dysphoria with smothery sensation, the lung-heat cough with asthma, restlessness and thirst, damp and hot obstruction of meridian, the symptoms such as the pyretic arthralgia of arthralgia.

Herba Lophatheri: have another name called Folium Bambusae, sweet in the mouth, light, cold in nature, enter the heart, lung, small intestine meridian, clearing away heart-fire and clear small intestine fire are arranged, analgesic relieving restlessness, diuretic quenches the thirst, and the effect of preventing phlegm from forming and stopping coughing is mainly used in the epidemic febrile disease restlessness and thirst, and the remnant pathogenic heat being not dispelled is to dysphoria and insomnia; The aphtha of the mouth and tongue of flaming up of heart-fire; Heat in the heart moves the symptoms such as difficulty and pain in micturition in small intestinal, excessive thirst, and staphylococcus aureus and bacillus pyocyaneus are had inhibitory action.

Gypsum Fibrosum and Folium Bambusae share, the effect that has clearing away heat-fire, relieving restlessness to quench the thirst, and treating heart stomach has heat, or calentura later stage waste heat is not to the greatest extent to thirsty agitation.

All the eliminating the pathogens from the lung excess of the stomach is fiery clearly for Gypsum Fibrosum and the Rhizoma Anemarrhenae, Gypsum Fibrosum is mineral drug, pathogenic fire reducing power is strong, expelling pathogenic factors from muscles heat and rush down positive bright stomach-fire, focus on cleaning, but use separately Gypsum Fibrosum prevention and treatment to have the pig of high-pathogenicity blue ear disease, because Gypsum Fibrosum is hot cold, although use in a large number the effectively treatment high-pathogenicity blue ear disease of energy, cause very large injury can for the taste of pig, and Gypsum Fibrosum is not good for the therapeutic effect of the ill pig that is in the high-pathogenicity blue ear disease later stage, and the Rhizoma Anemarrhenae is plant amedica, and the double kidney channel of returning of matter profit focuses on clearly and grows, again can nourshing Yin and drynsessmoistening prescription logical intestinal, the removing the relative excess fire can be moisturized again, and Gypsum Fibrosum and Rhizoma Anemarrhenae mutual reinforcement between are usefulness, and the power of removing summer-heat excess-heat significantly strengthens, because of not only pathogenic fire purging but also grow dryness of the stomach, therefore though large bitter Great Cold is also without the anxiety of imapirment of the spleen and stomach, to calentura mid-term, the later stage heresy enters edema caused by disorder of QI, and excess-heat is flourishing, the excessive thirst taking fluids profusely, the flushed complexion arteries and veins is red etc., and symptom has extraordinary curative effect.

Flos Lonicerae: have another name called Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, two precious flowers, sweet in the mouth, cold in nature enters the heart, lung, stomach, large intestine channel, the effect of heat-clearing and toxic substances removing is arranged, holding concurrently can eliminating pathogenic heat from blood to cure dysentery, is mainly used in affection due to external wind and heat, the epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; The fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has preferably antipyretic effect, and antiinflammatory action is arranged, and can promote leukocytic phagocytic function, and multiple pyococcus and pathogenic entero becteria are had stronger bacteriostasis.

Radix Angelicae Sinensis: sweet in the mouth, suffering, warm in nature, enter liver, the heart, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation is mainly used in having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, and other syndrome of deficiency of blood; The sea of blood is hollow, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, dysmenorrhoea, produce or stomachache, and other blood stasis are had a pain and the symptoms such as constipation of deficiency of YIN insufficiency of blood dryness of the intestine, its can improve the uterus blood circulation, alleviate pelvic congestion, relieving dysmenorrhea, in addition, the immunity that Radix Angelicae Sinensis can enhancing body.

Radix Angelicae Sinensis has the effect of removing blood stasis and activating blood flow pain relieving, Flos Lonicerae cooperates with it, one walks edema caused by disorder of QI, one walks blood system, QI and blood is ruled together, and both can fall clearly the heat in the lung, and clearing heat in QI system divides the merit that removing heat from blood is held concurrently in stagnated fire again, walk to detoxify altogether dissipating blood stasis, let out and stop up logical stagnant merit, be used for the treatment of pyretic toxicity and stop up the skin ulcer of the blood vessels that stagnate and swell from the beginning of symptoms such as swelling pains.

Radix Scutellariae: bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, antiabortive, the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.

Radix Paeoniae Rubra: bitter in the mouth, little hardship, enter Liver Channel, removing fire from the liver is arranged, clearing away heat and cooling blood, the effect of stasis-dispelling and pain-killing is mainly used in the vigorous conjunctival congestion and swelling pain of liver-fire, has a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, macule is hemorrhage, and the blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Blood blocks caused various pain; The symptoms such as furuncle carbuncle of heat in blood poison Sheng.

Radix Stellariae: sweet in the mouth, be slightly cold, enter liver, stomach warp, useful kidney yin, reducing the asthenic fever, the strengthening the spleen stomach, the effect of the infantile malnutrition that disappears is mainly used in yin asthenia generating intrinsic heat, night sweat spontaneous perspiration, hectic fever due to YIN-deficiency consumptive fever and infantile malnutrition, the symptoms such as dry thirsty dry urgency

Folium Sennae: sweet in the mouth, hardship, cold in nature, enter large intestine channel, purging heat to relax the bowels is arranged, the stagnate merit of diuretic of row is mainly used in the constipation of the stagnant the intestines and stomach of accumulation of heat, the abdominal distention abdominal distention of accumulation of food in the stomach and intes tine due to indigestion, the symptoms such as anorexia.

The Radix Astragali: sweet in the mouth, warm in nature, return lung, spleen channel, tonification spleen soil is arranged, the elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting are mainly used in treating the weak anorexia and loose stool due to the deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, the chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency; Insufficiency of vital energy and blood, yang-energy skin infection on the decline do not rise, difficulty in discharging of pus, burst and not hold back for a long time; And the deficiency of vital energy is lost the edema of fortune; the symptoms such as dysuria; the Radix Astragali has dual regulation to animal blood glucose; can increase anemia person's erythrocyte and hemoglobin; promote leukocyte and thrombocytopenia person to recover normal; and can improve or recover erythrocytic function, can improve the non-specific immunity of body.。

Radix Codonopsis: sweet in the mouth, property is flat, enters lung, spleen channel, and the QI invigorating strengthening the spleen is arranged, the effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach, transfer regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes intestinal to the absorption of nutrient substance.

The drug action mechanism of Chinese medicine composition of the present invention is as follows: the Rhizoma Anemarrhenae and Gypsum Fibrosum are reused, be mainly used in clearly eliminating the pathogens from the lung excess of the stomach fire, the excess-heat of main clear positive bright edema caused by disorder of QI, the Rhizoma Anemarrhenae can also have inhibition or killing action to most of gram positive bacterias and negative bacterium, Radix Trichosanthis, Folium Bambusae, the adding of Rhizoma Phragmitis, improved the effect of the Rhizoma Anemarrhenae and Gypsum Fibrosum, and can promote whole Chinese medicine composition still not bring into play to the greatest extent effect at the later stage waste heat, Radix Codonopsis, Radix Angelicae Sinensis and the Radix Astragali have the effect of enhancing human body immunity power and resistance, the effect of the movement that the prevention of highly pathogenic PRRS is played, Radix Angelicae Sinensis can also provide a large amount of vitamin and trace element to guarantee the symptom of organism metabolism, the Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication is good at clearing away lung-heat especially, be the medicine of suiting the medicine to the illness for the treatment of highly pathogenic PRRS, the adding of Folium Sennae promotes the elimination that the intestines and stomach is stagnant.

Further preferred, described Chinese medicine composition for prevention and the high pathogenic pig blue-ear disease for the treatment of only is made of said components.

Described Chinese medicine composition for prevention and treatment highly pathogenic PRRS, the ratio of weight and number of various components can be preferably: the Rhizoma Anemarrhenae 40～60 weight portions, Gypsum Fibrosum 25～35 weight portions, Radix Trichosanthis 10～20 weight portions, Herba Lophatheri 10～20 weight portions, Rhizoma Phragmitis 10～20 weight portions, Flos Lonicerae 5～15 weight portions, Radix Scutellariae 15～25 weight portions, Radix Paeoniae Rubra 5～15 weight portions, Radix Stellariae 5～15 weight portions, Radix Angelicae Sinensis 15～25 weight portions, Folium Sennae 5～15 weight portions, Radix Codonopsis 15～25 weight portions and the Radix Astragali 15～25 weight portions.

Described Chinese medicine composition for prevention and treatment animal highly pathogenic PRRS, the ratio of weight and number of various components also can be more preferably: the Rhizoma Anemarrhenae 50～60 weight portions, Gypsum Fibrosum 30～35 weight portions, Radix Trichosanthis 15～20 weight portions, Herba Lophatheri 15～20 weight portions, Rhizoma Phragmitis 15～20 weight portions, Flos Lonicerae 10～15 weight portions, Radix Scutellariae 20～25 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Stellariae 10～15 weight portions, Radix Angelicae Sinensis 20～25 weight portions, Folium Sennae 10～15 weight portions, Radix Codonopsis 20～25 weight portions and the Radix Astragali 20～25 weight portions.

Described Chinese medicine composition for prevention and treatment highly pathogenic PRRS can also comprise Semen Cuscutae.

Semen Cuscutae: sweet in the mouth, suffering, property is flat, enters the liver,kidney,spleen warp, and the kidney invigorating and essence nourishing is arranged, and the effect of nourishing the liver to improve visual acuity is mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; The pain in the lumbar region of suffering from a deficiency of the kidney, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the symptoms such as aqueous-grainy diarrhea by adding Semen Cuscutae, promote the reparation of liver and kidney cells, nourishing kidney-yin, protecting liver and detoxication enhances metabolism, slow down epidemic situation, strengthen resistance against diseases, the generation of reduce miscarriage simultaneously, producing stillborn fetus, weak tire or mummy tire.

Further preferred, described Chinese medicine composition for prevention and the high pathogenic pig blue-ear disease for the treatment of only is made of said components.

The ratio of weight and number of described Semen Cuscutae in described Chinese medicine composition is Semen Cuscutae 10～20 weight portions, more preferably 15～20 weight portions.

Described Chinese medicine composition for prevention and treatment highly pathogenic PRRS can also comprise Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus.

Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature enters spleen, stomach, Liver Channel, is used for promoting digestion and invigorating the stomach, and the circulation of qi promoting dissipating blood stasis is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, escherichia coli, bacillus pyocyaneus, staphylococcus aureus etc. had obvious inhibitory action.

Fructus Oryzae Germinatus: sweet in the mouth, property are put down, and enter spleen, stomach warp, are used for promoting digestion and removing stagnation, spleen benefiting and stimulating the appetite, and the primary treatment eating accumulation, wrist abdomen feeling of fullness, flesh is disliked food, insufficiency of the spleen few the food.

Pericarpium Citri Reticulatae Viride: bitter in the mouth, suffering, warm in nature, enter liver, gallbladder, stomach warp, have easypro gallbladder dispelling the stagnated QI, the stagnant effect of removing food stagnancyization, be used for stagnation of QI due to dyspepsia, abdominal distention, infantile malnutrition, old man's abdominal distention of stopping eating, gastrointestinal tract there is gentle stimulation, can facilitating digestion liquid secretion and get rid of gas in the body, again can the diastole gastrointestinal smooth muscle, main manifestations is for adjusting the effect of gastrointestinal function.

By adding these three kinds of auxiliary elements of upper Fructus Crataegi, Fructus Oryzae Germinatus and Pericarpium Citri Reticulatae Viride, can eliminate eating accumulation, facilitating digestion, increase enterogastric peristalsis, in case distension and fullness in the abdomen, lack of appetite, dysentery has and regulates the flow of vital energy, stomach function regulating, the effect of spleen invigorating, make pig feed want to increase, improve resistance against diseases and immunologic function, reduce the incidence rate of disease, play a role in health care, thus prevention and treatment highly pathogenic PRRS.

Further preferred, described Chinese medicine composition for prevention and the high pathogenic pig blue-ear disease for the treatment of only is made of said components.

Described Fructus Crataegi, Pericarpium Citri Reticulatae Viride, the ratio of weight and number of Fructus Oryzae Germinatus in described Chinese medicine composition are Fructus Crataegi 3～5 weight portions, Pericarpium Citri Reticulatae Viride 3～5 weight portions and Fructus Oryzae Germinatus 3～5 weight portions.

Described Chinese medicine composition for prevention and treatment highly pathogenic PRRS can also comprise Radix Glycyrrhizae.

Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play the QI invigorating neutralization by adding Radix Glycyrrhizae, be in harmonious proportion the effect of each component, simultaneously Radix Glycyrrhizae can in and the endotoxin that produces in the metabolism, keep digesting and assimilating normally and excretory function of ill pig, can prevent that just the endotoxic savings of ill pig is poisoned and disappearing of later stage physical function exhausts death.

Further preferred, described Chinese medicine composition for prevention and the high pathogenic pig blue-ear disease for the treatment of only is made of said components.

The ratio of weight and number of described Radix Glycyrrhizae in described Chinese medicine composition is Radix Glycyrrhizae 5～10 weight portions.

Described Chinese medicine composition for prevention and treatment highly pathogenic PRRS can also comprise Colla Corii Asini.

Colla Corii Asini: sweet in the mouth, property are flat, enter lung, liver, kidney channel, and tonifying blood and arresting bleeding is arranged, and nourshing Yin and drynsessmoistening prescription effect can be used for the shallow complexion of various asthenia symptom, especially blood deficiency, and thin and weak weak, the head is dizzy, palpitation and insomnia; Malnutritional anemia, thrombocytopenic purpura; Deficient property hemoptysis; The haematemesis hematuria is had blood in stool; The cough dry pharynx of lung-dryness syndrome due to deficiency of YIN, sputum mixed with blood; The symptoms such as the spasm of muscles and vessels of pathogenic heat lingering, deficiency of YIN blood consumption, stirring-up of pathogenic wind in the interior resulting from deficiency, tetany, Colla Corii Asini has the erythrocytic generation of promotion, increases blood calcium concentration, promotes the effect of hemostasis, and helps to strengthen the immunologic function of animal.

Further preferred, described Chinese medicine composition for prevention and the high pathogenic pig blue-ear disease for the treatment of only is made of said components.

The ratio of weight and number of described Colla Corii Asini in described Chinese medicine composition is Colla Corii Asini 5～10 weight portions.

The pharmacological action of Chinese medicine composition of the present invention stops cytometaplasia for directly killing antigen, removes the body obstacle, the enhancing body function, steadily neuroendocrine disturbance recovers immunologic function, Quick-return appetite, stimulate body reinforced platoon exclusive-OR function, analgesic antiinflammatory does not rebound, and induces cause of disease, toxin, dead cell to compile and excrete self falling after inflammation is eliminated to injection point, venesection, the toxin expelling function of promoting blood circulation to disperse blood clots is arranged, have artificial lymphatic function.

The present invention also provides above-mentioned preparation method for preventing and treat the Chinese medicine composition of highly pathogenic PRRS, and it comprises:

The first step is packed the Rhizoma Anemarrhenae in the multi-function extractor into, adds alcohol heating reflux and extracts, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, obtain extractum, with the extractum stored refrigerated, enter subsequently in the spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes;

Second step is pulverized Gypsum Fibrosum, decocts with water 2～4 times, merges decoction liquor, filters, and static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is dried to dried cream except anhydrating, and pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders;

The 3rd step, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae and Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder;

The 4th step decocted with water Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali respectively 2～4 times, merged decoction liquor separately, filtered, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder;

In the 5th step, with being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition.

In the described first step, the pure quality that contains of the ethanol that adds is 85%～95%, the reflux time is 2 hours～4 hours, the number of times that extracts is preferably 2～4 times, the quality optimization of the ethanol that adds is 5～10 times of Rhizoma Anemarrhenae quality, the concentrating under reduced pressure Recycled ethanol, the quality that reclaims when ethanol stops recovery when above for 75% of the quality of the initial ethanol that adds, the extractum refrigerated storage temperature is preferably 0～3 ℃, when adopting spray dryer to carry out drying, inlet temperature is preferably 150 ℃～170 ℃, and leaving air temp is preferably 50 ℃～60 ℃.

In the described second step, decocting time is 1 hour～3 hours, and the quality optimization of the water of adding is 3～5 times of gypsum quality sum.

In described the 4th step, decocting time is 1 hour～3 hours, and the quality optimization of the water of adding is separately 3～5 times of quality of Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali.

Also further comprise in the described preparation method, Semen Cuscutae is pulverized, decoct with water 1～3 time, decocting time is 1 hour～3 hours, the quality optimization of the water that adds is 3～5 times of Semen Cuscutae quality, merges decoction liquor, filters, static spending the night, extract the upper strata stillness of night, concentrating under reduced pressure is dried to dried cream except anhydrating, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder.

Also further comprise in the described preparation method, Radix Glycyrrhizae is put into marmite fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder.

Also further comprise in the described preparation method, with Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus co-grinding, decoct with water 1～3 time, decocting time is 1 hour～3 hours, the quality optimization of the water that adds is Fructus Crataegi, Pericarpium Citri Reticulatae Viride and Fructus Oryzae Germinatus quality sum 3～5 times, merges decoction liquor, filters, static spending the night, extract the upper strata stillness of night, concentrating under reduced pressure is dried to dried cream except anhydrating, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder.

Also further comprise in the described preparation method, Colla Corii Asini is decocted with water 1～3 time, and decocting time is 1 hour～3 hours, and the quality optimization of the water of adding is 3～5 times of Colla Corii Asini quality, merge decoction liquor, filter, static spending the night extracted the upper strata stillness of night, concentrating under reduced pressure is except anhydrating, be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder.

Described Chinese medicine composition dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.

The administering mode of described Chinese medicine composition is oral.

The present invention also provides the using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition is put into water-soluble stirring and soaked decoction, gavage subsequently to the pig that suffers from highly pathogenic PRRS, gavage continuously 3 days～5 days.

The present invention also provides the another kind of using method of above-mentioned Chinese medicine composition, it comprises: with described Chinese medicine composition and feed vector phase mix and blend, the ill pig of mixture feeding that will stir subsequently, 5 days～7 days is a course for the treatment of, continuously 10 week～12 weeks of feeding.

The present invention also provides a kind of fodder compound, comprises above-mentioned Chinese medicine composition additive and feed vector in the said composition.

Described feed vector is preferably one or more in Semen Maydis, Semen Tritici aestivi, Fructus Hordei Vulgaris, the bean cake.

The ratio of weight and number of described feed vector and described Chinese medicine composition additive can be 100 weight portions: 5～15 weight portions, more preferably 100 weight portions: 10～15 weight portions.

Can also comprise enzymatic compositions in the described fodder compound, with respect to the feed vector of 100 weight portions, the weight fraction of described enzymatic compositions is 3～5 weight portions.

Described enzymatic compositions comprises 1,4 beta-glucanase, 'beta '-mannase, cellulase, amylase and protease.

The ratio of weight and number of various enzymes is 1,4 beta-glucanase 30～45 weight portions in the described enzymatic compositions, 'beta '-mannase 10～15 weight portions, cellulase 3～6 weight portions, amylase 15～25 weight portions, protease 15～30 weight portions.

Can also add other the additive such as ammonium sulfate, sodium bicarbonate and maltodextrin in the described fodder compound.

With respect to the feed vector of 100 weight portions, the ratio of weight and number of each additive component is that described ammonium sulfate is preferably 3～5 weight portions in the described fodder compound, and described sodium bicarbonate is preferably 1～3 weight portion, and described maltodextrin is preferably 3～5 weight portions.

The present invention also provides the preparation method of above-mentioned fodder compound, and it comprises:

The first step prepares the described Chinese medicine composition as additive;

Second step, in described ratio with feed vector and and prepared Chinese medicine composition additive pulverize, add entry and mix, whipping temp maintains 30～40 ℃, mixing time is 40～60 minutes, wherein, with respect to the feed vector of 100 weight portions, the amount of the water that adds is preferably 35～50 weight portions;

The 3rd step, the material that obtains in the second step is put into the steam manipulator carry out pre-gelatinizing, in this step, the temperature in the steam manipulator is preferably 75 ℃～80 ℃, and at this moment, the starch burn degree of feedstuff is 60～70%;

The 4th step, the 3rd material that goes on foot pre-gelatinizing is carried out steam in extruder boil and push, in this step, described extruder can be single-screw extrusion machine or twin (double) screw extruder, temperature in the extruder is preferably 105～115 ℃, pressure is adjusted to 0.7MPa～1.6MPa, and at this moment, the starch burn degree of feedstuff is 95～98%;

The 5th step is with the described fodder compound of the dry acquisition of the material that obtains in the 4th step.

In the preparation method of described fodder compound, can also first described enzymatic compositions and described feed vector fully be mixed in described ratio in the second step, add entry, under preferred 30～40 ℃ temperature, stir, after preferred 30～50 minutes, add described Chinese medicine composition additive, remain on and continue under 30～40 ℃ the temperature to stir 20～40 minutes, further add ammonium sulfate, sodium bicarbonate and maltodextrin in described ratio subsequently and further stirred 10～20 minutes.

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.

The pathological change of highly pathogenic PRRS is: suffer from pig and typical icteroanemia occurs, cut open the visible mucosa of inspection, palor for eperythrozoonosis characteristic pathological change after death, blood is thin, the spleen enlargement, lymphadenectasis, ascites, hydrothorax, hydropericardium.Histopathologic examination has: cerebrovascular endothelial cell swelling, and there is the serosity cellulose to ooze out, the brain mantle is congested, hemorrhage, a large amount of leukocyte recruitments.Neurocyte nuclear swelling, necrosis, fragmentation.Bone marrow proliferation.Liver has iron content blood yellow pigmentation, the lobules of liver partial necrosis, and hepatocyte cloudy swelling, vacuolar degeneration have petechial hemorrhage and necrosis region, the central vein expansion, edema, hepatic sinusoid expansion, interlobular bile duct expansion, interstitial pneumonia, splenaemia, hemorrhage, the folliculus fibroplasia, folliculus disappears.

Embodiment 1 Chinese medicine composition of the present invention is to the acute toxicity test of mice

1. experimental animal

The healthy KM mice of SPF level, 30, male and female half and half, body weight 20-25g; Available from the Sichuan Provincial Academy of Traditional Chinese Medicine Experimental Animal Center

2. trial drug

The 60g Rhizoma Anemarrhenae is packed in the multi-function extractor (Shanghai along instrument scientific ﹠ technical corporation produce), the alcohol heating reflux that adds 300g 90% extracts 2 times, each 3 hours, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, when the ethanol quality that reclaims for the initial ethanol quality that adds 80% the time stop to reclaim, obtain extractum, 0 ℃ of stored refrigerated, enter subsequently in the spray dryer (Changzhou section dragon drying machinery equipment company limited is produced) dry extractum, inlet temperature is 160 ℃, leaving air temp is 60 ℃, pulverizes and sieves with pulverizer, and obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes; The 35g Gypsum Fibrosum is pulverized, added the 105g decocting and boil 3 times, decocted 2 hours at every turn, merge decoction liquor, filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is dried to dried cream except anhydrating, and pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders; 20g Radix Trichosanthis, 20g Herba Lophatheri, 20g Rhizoma Phragmitis, 15g Flos Lonicerae, 25g Radix Scutellariae, 15g Radix Paeoniae Rubra, 15g Radix Stellariae and 15g Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; 25g Radix Angelicae Sinensis, 25g Radix Codonopsis and the 25g Radix Astragali are added respectively the 75g decocting to be boiled 3 times, each 2 hours, merge decoction liquor separately, filter, static spending the night extracted the upper strata stillness of night, concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder; With being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition.

3. detectable

Serum AST, ALT detection kit are available from giving birth to company in Beijing

4. checkout equipment

Micro-200 semiautomatic biochemistry detector, analytical balance, dissecting instrument, syringe, test tube etc.

5. test method

After 3 days adaptabilities are raised, be divided at random 5 groups (male and female half and half), every group each 10; Matched group, 4 various dose groups (only be respectively 76mg/, 152.1mg/, 219.9mg/, 357.6mg/ only).Mice free choice feeding, drinking-water in the feeding process, change water every day, the next day change bedding and padding.Whole experimental period is 7 days.

6. testing index and method

(1) clinicing symptom observation: every day the viewing test Mus the mental status, diet situation, every day entry Mortality situation.

(2) pathological observation: cut open inspection for dead Mus and observe the internal organs variation.

(3) growth indexes is observed: the test Mus is carried out routine weighing; Off-test, slaughter that Mus weighs in, the heavy organ index of internal organs measures: cut open the inspection kunming mice, dirty, the spleen of coring, liver, kidney, testis, ovary are weighed, and are calculated according to the following formula organ index: organ index=internal organs weight/body weight * 100.

(4) liver function changes observation: after the off-test, slaughter Mus, take blood separation serum, measure AST, ALT.

7. date processing: above the data SPSS11.0 carries out analytic statistics.

Clinicing symptom observation

Matched group and test group Mus, the mental status and diet are wanted, respond has no significantly unusual to external world.Each organizes Mus morbidity and death condition such as following table 1.

Table 1

Grouping	Sum	Morbidity (only)	Dead (only)	Mortality rate (%)
					1 (76mg/ only)	10	0	0	0
2 (152.1mg/ only)	10	0	0	0
					3 (219.9mg/ only)	10	0	0	0
4 (357.6mg/ only)	10	0	0	0
					Matched group	10	0	0	0

Pathological observation: matched group and test group, cut open after Mus is slaughtered to examine to observe to have no and observe the obvious pathological change of internal organs.

Growth indexes is observed: off-test, slaughter that Mus weighs in, the internal organs weight analysis sees Table 2.

Table 2

Grouping	The liver index	Cardiac index	Renal index	The lungs index	Index and spleen index
						1 (76mg/ only)	5.57 +0.11	0.73 +0.06	1.31 +0.09	0.67 +0.06	0.42 +0.03
2 (152.1mg/ only)	5.73 +0.29	0.72 +0.05	1.27 +0.11	0.69 +0.03	0.47 +0.06
						3 (219.9mg/ only)	5.61 +0.17	0.69 +0.11	1.36 +0.17	0.71 +0.06	0.49 +0.09
4 (357.6mg/ only)	5.92 +0.25	0.70 +0.02	1.35 +0.21	0.69 +0.11	0.50 +0.02
						Matched group	5.17 +0.16	0.75 +0.03	1.40 +0.11	0.67 +0.09	0.51 +0.09

Liver function changes to be observed

After the off-test, slaughter Mus, take blood separation serum, measure AST, ALT and see Table 3.The result shows and respectively organizes data and normal healthy controls group to compare difference not remarkable, all is in normal range.

Table 3

Grouping	Sum	ALT	AST
				1 (76mg/ only)	10	39.26 +3.61	129.19 +13.79
2 (152.1mg/ only)	10	37.15 +2.19	137.45 +21.03
				3 (219.9mg/ only)	10	38.56 +3.01	133.67 +19.21
4 (357.6mg/ only)	10	38.97 +1.59	135.27 +15.62
				Matched group	10	40.12 +5.33	136.29 +17.58

Embodiment 2 Chinese medicine compositions of the present invention are to the long term toxicity test of ill pig

Get 10 of adult ill pigs, body weight is at 150～200kg, male and female half and half, the long-term administration of 12 weeks, carry out long term toxicity test, the result shows that the indexs such as all pig general status, growth promoter, routine blood test, liver, renal function are showed no abnormal change, and histopathology and gross necropsy also have no pathological change.

The preparation of embodiment 3 Chinese medicine compositions 1

The 600g Rhizoma Anemarrhenae is packed in the multi-function extractor (Shanghai along instrument scientific ﹠ technical corporation produce), the alcohol heating reflux that adds 3000g 90% extracts 2 times, each 3 hours, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, when the ethanol quality that reclaims for the initial ethanol quality that adds 80% the time stop to reclaim, obtain extractum, 0 ℃ of stored refrigerated, enter subsequently in the spray dryer (Changzhou section dragon drying machinery equipment company limited is produced) dry extractum, inlet temperature is 160 ℃, leaving air temp is 60 ℃, pulverizes and sieves with pulverizer, and obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes; The 350g Gypsum Fibrosum is pulverized, added the 1050g decocting and boil 3 times, decocted 2 hours at every turn, merge decoction liquor, filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is except anhydrating, be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～150 purpose gypsum powders; 200g Radix Trichosanthis, 200g Herba Lophatheri, 200g Rhizoma Phragmitis, 150g Flos Lonicerae, 250g Radix Scutellariae, 150g Radix Paeoniae Rubra, 150g Radix Stellariae and 150g Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; 250g Radix Angelicae Sinensis, 250g Radix Codonopsis and the 250g Radix Astragali are added respectively the 750g decocting to be boiled 3 times, each 2 hours, merge decoction liquor separately, filter, static spending the night extracted the upper strata stillness of night, concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder; The 200g Semen Cuscutae is pulverized, added the 150g decocting and boil 3 times, each decocting time is 1 hour, merges decoction liquor, filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is except anhydrating, be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder; The 100g Radix Glycyrrhizae is put into marmite fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; With the 50g Fructus Crataegi, 50g Pericarpium Citri Reticulatae Viride and 50g Fructus Oryzae Germinatus co-grinding, adding the 450g decocting boils 2 times, each decocting time is 3 hours, merges decoction liquor, filters, static spending the night, extract the upper strata stillness of night, concentrating under reduced pressure is dried to dried cream except anhydrating, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder, the 100g Colla Corii Asini is added in the 300g water decoct 3 times, and each decocting time is 1 hour, merge decoction liquor, filter, static spending the night extracted the upper strata stillness of night, concentrating under reduced pressure is except anhydrating, be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～200 purpose powder, with being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition 1.

The preparation of embodiment 4 Chinese medicine compositions 2

The 500g Rhizoma Anemarrhenae is packed in the multi-function extractor (Shanghai along instrument scientific ﹠ technical corporation produce), the alcohol heating reflux that adds 2500g 90% extracts 2 times, each 3 hours, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, when the ethanol quality that reclaims for the initial ethanol quality that adds 80% the time stop to reclaim, obtain extractum, 0 ℃ of stored refrigerated, enter subsequently in the spray dryer (Changzhou section dragon drying machinery equipment company limited is produced) dry extractum, inlet temperature is 160 ℃, leaving air temp is 60 ℃, pulverizes and sieves with pulverizer, and obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes; The 300g Gypsum Fibrosum is pulverized, added the 900g decocting and boil 3 times, decocted 2 hours at every turn, merge decoction liquor, filter, static spending the night extracted the upper strata stillness of night, and concentrating under reduced pressure is except anhydrating, be dried to dried cream, pulverize and sieve with pulverizer, obtaining granularity is 100～150 purpose gypsum powders; 150g Radix Trichosanthis, 150g Herba Lophatheri, 150g Rhizoma Phragmitis, 100g Flos Lonicerae, 200g Radix Scutellariae, 100g Radix Paeoniae Rubra, 100g Radix Stellariae and 100g Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder; 200g Radix Angelicae Sinensis, 200g Radix Codonopsis and the 200g Radix Astragali are added respectively the 600g decocting to be boiled 3 times, each 2 hours, merge decoction liquor separately, filter, static spending the night extracted the upper strata stillness of night, concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder; With being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition 2.

The preparation of embodiment 5 fodder compounds 1

Chinese medicine composition 1 additive of 10kg wheatfeed carrier and 1.5kg embodiment 3 preparations is pulverized, is added 3.5kg water and mixes, whipping temp maintains 40 ℃, mixing time is 60 minutes, the material that obtains is put into the steam manipulator and is carried out pre-gelatinizing, temperature in the steam manipulator is 80 ℃, at this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The described fodder compound 1 of the dry acquisition of the material that obtains.

The preparation of embodiment 6 fodder compounds 2

Chinese medicine composition 2 additives of 10kg wheatfeed carrier and 1kg embodiment 4 preparations are pulverized, are added 3.5kg water and mix, whipping temp maintains 40 ℃, mixing time is 60 minutes, the material that obtains is put into the steam manipulator and is carried out pre-gelatinizing, temperature in the steam manipulator is 80 ℃, at this moment, the starch burn degree of feedstuff is 65%; The material of gelatinizing is carried out steam boil and push in single-screw extrusion machine, the temperature in the extruder is 105 ℃, and pressure is adjusted to 1.6MPa, and at this moment, the starch burn degree of feedstuff is 98%; The described fodder compound 2 of the dry acquisition of the material that obtains.

Clinical experiment 1

With 360 health pig (male and female half and half, body weight is between 150kg～200kg) be divided at random three groups, group I is the counteracting toxic substances matched group, group II is the test group of taking the Chinese medicine composition 1 rear counteracting toxic substances that embodiment 3 makes, group III is the test group of taking the Chinese medicine composition 2 rear counteracting toxic substances that embodiment 4 makes, group I only feeds with the normal feedstuff Semen Tritici aestivi, and every day, Chinese medicine composition that every pig is joined was suitable with 1.5 gram raw material of Chinese medicine doses; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease pig symptom every day when 9:00 and 16:00, dead pig is weighed, the anatomic observation pathological change, and perform itemized record, carried out dead pig being weighed, dissecting in ten days to test, and record pathological changes situation, after test is finished, test mortality rate, effective percentage are carried out data statistics, and concrete outcome sees Table 4.

Table 4

Grouping	Sum	Ill number	Death toll	Mortality rate (%)	Effective percentage (%)
						Group I	120	120	98	81.7%	0
Group II	120	0	0	0	100%
						Group III	120	5	0	0	95.83%

In this experimentation, all symptom and death that occurs highly pathogenic PRRS at duration of test, the ill apparition person of necropsy is judged to and infects death.

Effectively after medication, not ill pig is effectively, and the percentage rate that every group of health pig number accounts for the test pig number is effective percentage.From table 4, we can find out, adopt Chinese medicine composition of the present invention that highly pathogenic PRRS is had significant preventive effect.

Clinical experiment 2

With 480 health pig (male and female half and half, body weight is between 150kg～200kg) be divided at random four groups, group I is the normal healthy controls group, group II is the counteracting toxic substances matched group, group III is the test group of taking the Chinese medicine composition 1 that embodiment 3 makes, the group IV is to take the test group of the Chinese medicine composition 2 that embodiment 4 makes, group I only feeds with the normal feedstuff Semen Tritici aestivi, group II uses the normal feedstuff Semen Tritici aestivi identical with the normal healthy controls group to feed, not administration behind the counteracting toxic substances, group III uses the normal feedstuff Semen Tritici aestivi identical with the normal healthy controls group to feed with the group IV, and after counteracting toxic substances the highly pathogenic PRRS typical clinical symptom occurred in 48 hours, sneak into Chinese medicine composition 1 and the Chinese medicine composition 2 that embodiment 3 and embodiment 4 make in the drinking-water in test group, every day, Chinese medicine composition that every pig is joined was suitable with 1.5 gram raw material of Chinese medicine doses; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease pig symptom every day when 9:00 and 16:00, dead pig is weighed, the anatomic observation pathological change, and perform itemized record, carried out dead pig being weighed, dissecting in ten days to test, and record pathological changes situation, after test is finished, test mortality rate, cure rate, effective percentage are carried out data statistics, and concrete outcome sees Table 5.

Table 5

?	Sick pig number	Death toll	Cure number	Significant figure	Mortality rate %	Cure rate %	Effective percentage %
								Group I	0	0	-	-	0	-	-
Group II	120	98	-	-	81.7%	-	-
								Group III	120	10	102	110	8.33%	85.0%	91.7%
The group IV	120	4	113	116	3.33%	94.2%	96.7%

In this experimentation, all symptom and death that occurs highly pathogenic PRRS at duration of test, the ill apparition person of necropsy is judged to and infects death.

Effectively after medication, dead pig be not effectively, the percentage rate that every group of survival pig number accounts for the test pig number be the effective percentage recovery from illness after medication, it is normal that the mental status, appetite etc. are recovered, and all belongs to recovery from illness, the percentage rate that the pig number of fully recovering accounts for the test pig number is cure rate.

From table 5, we can find out, adopt Chinese medicine composition of the present invention that highly pathogenic PRRS is had significant curative effect.

For example: in JIUYUE, 2010,180 growing and fattening pigs of main Liu's cultivation are raiseeed in Liu Jia village, Handan in Hebei province Sishui County, and all morbidities are suffered from temperature of pig body and are raise and reach 40 ℃～42 ℃, and be and delay pattern of fever, anorexia, bradykinesia is reluctant activity.Visible nasal secretion increases subsequently, cough, and dyspnea, visual mucosa is pale, jaundice.The feces initial stage is stiff and with mucus and mucosa, and constipation and diarrhoea alternately occur.Auricle, afterbody and limb end skin cyanosis are kermesinus or aubergine.Clinical diagnosis is highly pathogenic PRRS, and ill pig is fed by 1.5g/kg body weight dosage batch mixing, is used in conjunction 10 courses for the treatment of 7 days courses for the treatment of, final dead 5, cure 175, and cure rate is 92.2%, follows up a case by regular visits to so far not recurrence.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims (5)

1. Chinese medicine composition that is used for prevention and treatment highly pathogenic PRRS, it is characterized in that, described Chinese medicine composition is made by the Rhizoma Anemarrhenae, Gypsum Fibrosum, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae, Radix Angelicae Sinensis, Folium Sennae, Radix Codonopsis and the Radix Astragali;

The weight portion of each raw material is the Rhizoma Anemarrhenae 50～60 weight portions, Gypsum Fibrosum 30～35 weight portions, Radix Trichosanthis 15～20 weight portions, Herba Lophatheri 15～20 weight portions, Rhizoma Phragmitis 15～20 weight portions, Flos Lonicerae 10～15 weight portions, Radix Scutellariae 20～25 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Stellariae 10～15 weight portions, Radix Angelicae Sinensis 20～25 weight portions, Folium Sennae 10～15 weight portions, Radix Codonopsis 20～25 weight portions and the Radix Astragali 20～25 weight portions.

2. Chinese medicine composition as claimed in claim 1 is characterized in that, described Chinese medicine composition is prepared from by the following method:

The first step is packed the Rhizoma Anemarrhenae in the multi-function extractor into, adds alcohol heating reflux and extracts, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, obtain extractum, with the extractum stored refrigerated, enter subsequently in the spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes;

Second step is pulverized Gypsum Fibrosum, decocts with water 2～4 times, merges decoction liquor, filters, and standing over night is extracted the supernatant, and concentrating under reduced pressure is dried to dried cream except anhydrating, and pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders;

The 3rd step, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae and Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder;

The 4th step decocted with water Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali respectively 2～4 times, merged decoction liquor separately, filtered, standing over night is extracted the supernatant, and concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder;

In the 5th step, with being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition.

3. the preparation method of Chinese medicine composition claimed in claim 1 is characterized in that, comprising:

The first step is packed the Rhizoma Anemarrhenae in the multi-function extractor into, adds alcohol heating reflux and extracts, merge extractive liquid,, centrifugal, filter, obtain filtrate, the concentrating under reduced pressure Recycled ethanol, obtain extractum, with the extractum stored refrigerated, enter subsequently in the spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 purpose Common Anemarrhena Rhizomes;

Second step is pulverized Gypsum Fibrosum, decocts with water 2～4 times, merges decoction liquor, filters, and standing over night is extracted the supernatant, and concentrating under reduced pressure is dried to dried cream except anhydrating, and pulverizes and sieves with pulverizer, and obtaining granularity is 100～150 purpose gypsum powders;

The 3rd step, Radix Trichosanthis, Herba Lophatheri, Rhizoma Phragmitis, Flos Lonicerae, Radix Scutellariae, Radix Paeoniae Rubra, Radix Stellariae and Folium Sennae are mixed, put into marmite and fry into charcoal, be ground into smalls with pulverizer, sieve, obtaining granularity is 100～200 purpose powder;

The 4th step decocted with water Radix Angelicae Sinensis, Radix Codonopsis and the Radix Astragali respectively 2～4 times, merged decoction liquor separately, filtered, standing over night is extracted the supernatant, and concentrating under reduced pressure is except anhydrating, be dried to respectively dried cream, pulverize and sieve, obtain 70～120 purpose Chinese Angelica Roots, Radix Codonopsis powder and Radix Astragali powder;

In the 5th step, with being stirred to evenly under the normal temperature and pressure conditions in the above-mentioned powder input blender, obtain described Chinese medicine composition.

4. a fodder compound is characterized in that, comprising: as Chinese medicine composition claimed in claim 1 and the feed vector of additive.

Chinese medicine composition claimed in claim 1 for the preparation of the prevention and the treatment highly pathogenic PRRS medicine in application.