CN105475651A - Feed capable of preventing and treating porcine reproductive and respiratory syndrome - Google Patents
Feed capable of preventing and treating porcine reproductive and respiratory syndrome Download PDFInfo
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Abstract
The invention provides a feed capable of preventing and treating porcine reproductive and respiratory syndrome. The raw materials of the feed include medicinal powder for preventing and treating the porcine reproductive and respiratory syndrome, corn, bean pulp, table salt, fish meal, zinc methionine, lysine, vitamin A, vitamin C and ethoxyquin. The feed has the characteristics of being low in poison and harmfulness to animals, low in medicine residue and the like, and has more obvious advantage in the aspect of preventing and treating the porcine reproductive and respiratory syndrome.
Description
Technical field
The present invention relates to field of feed, particularly relate to a kind of feed preventing and treating porcine reproductive and respiratory syndrome.
Background technology
Porcine reproductive and respiratory syndrome (PorcineReproductiveandRespira-tionSyndrome, PRRS) be a kind of Acute exposure sexually transmitted disease caused by porcine reproductive and respiratory syndrome virus, mainly cause the breeding difficulty of in-pig and the respiratory symptom of piglet, cause the mortality of the breeding difficultys such as in-pig miscarriage, stillborn foetus, mummy tire, weak son and piglet.This disease is a kind of acute, high lethal infectious diseases, and viral pathogenesis power is strong, and spread speed is fast, and swinery M & M is high, and the piglet incidence of disease can reach 100% death rate can reach more than 30%, and Sow abortion rate can reach more than 30%.Growing and fattening pigs, sow also can be fallen ill death.
This disease there is no effective methods for the treatment of so far, and vaccine prevention is main measure.The research of vaccine obtains remarkable break-throughs, and commercial PRRS vaccine has inactivated vaccine and attenuated live vaccines two class in the world.The main Problems existing of PRRS vaccine is clinically: the first, and vaccine produces immune response needs the long period; Secondly, PRRSV vaccine does not have protection completely, and especially inactivated vaccine can not activated cell immunity; Can there is a few time-of-week in the three, PRRSV attenuated vaccine, and propagate from note seedling pig to susceptible pig in immune swine soma.Therefore, application inactivated vaccine strengthens vaccine immunity effect and security, and the immune effect that development immunopotentiator improves PRRS inactivated vaccine has significant advantage.
Discovered in recent years Chinese medicine has prevented good effect to viral disease, and therefore development goes out Chinese medicine preparation and holds out broad prospects to prevent this disease.Chinese veterinarian thinks, PRRS belongs to temperature (epidemic disease) sick category, is the disease because pig causes by the dry outer evil invasion and attack such as cold of abnormally climatic pathogens,all exogenous pathogens, hot summer weather, has the features such as infectiousness, popularity, high heat.The mechanism of Chinese herb prevention PRRS has direct effect and indirectly-acting, direct effect be Chinese medicine preparation blocking virus to Normocellular absorption, penetrate, the link such as to copy and reach antiviral object.Indirectly-acting be Chinese medicine by body regulating action, strengthen cellular immunity, the humoral immunity of body, immune cell activated, the generation of inducing interferon, impel virus can not in porcine somatic cell survival and reproduction, and play the effect of anti-PRRSV.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing and treating the medicine of porcine reproductive and respiratory syndrome and comprising the feed of this medicine, it poisons little to animal, the features such as medicament residue is few, have more obvious advantage in anti-reproductive and respiratory syndrome processed.
For solving the problems of the technologies described above, the invention provides a kind of feed for preventing and treating porcine reproductive and respiratory syndrome, its raw material comprises drug powder, corn, dregs of beans, salt, fish meal, zinc methionine, lysine, vitamin A, vitamin C and ethoxyquinoline for preventing and treating porcine reproductive and respiratory syndrome.
Wherein, in described feed, the weight portion of each raw material is respectively drug powder 3 weight portion ~ 5 weight portion, corn 250 weight portion ~ 300 weight portion, dregs of beans 120 weight portion ~ 160 weight portion, salt 3 weight portion ~ 5 weight portion, fish meal 25 weight portion ~ 35 weight portion, zinc methionine 0.5 weight portion ~ 1.5 weight portion, lysine 0.5 weight portion ~ 1.5 weight portion, retinol1 weight portion ~ 2 weight portion, vitamin e1 weight portion ~ 2 weight portion, ethoxyquinoline 2 weight portion ~ 4 weight portion for preventing and treating porcine reproductive and respiratory syndrome.
Wherein, in described feed, the weight portion of each raw material is respectively drug powder 4 weight portion, corn 280 weight portion, dregs of beans 150 weight portion, salt 4 weight portion, fish meal 30 weight portion, zinc methionine 1 weight portion, lysine 1 weight portion, dehydroretinol weight portion, vitamin E2 weight portion, ethoxyquinoline 3 weight portion for preventing and treating porcine reproductive and respiratory syndrome.
Wherein, the bulk drug of described drug powder comprises barrenwort, sealwort, Gorgon fruit, Chinese ephedra, Centipeda minima, semen astragali complanati, the capsule of weeping forsythia, Companumoea root, water Cape jasmine, Chinese yam, moutan bark, RADIX ACONITILATERALIS PREPARATA, paniculate spotflower herb, honey-fried licorice root, awns beanstalk bone, entire micromelum root-brak or leaf, mountain eel grass and sweet clover.
Wherein, in described drug powder, the weight of each bulk drug is respectively barrenwort 20g ~ 30g, sealwort 25g ~ 35g, Gorgon fruit 15g ~ 25g, Chinese ephedra 10g ~ 20g, Centipeda minima 20g ~ 30g, semen astragali complanati 25g ~ 35g, capsule of weeping forsythia 15g ~ 25g, Companumoea root 35g ~ 45g, water Cape jasmine 10g ~ 20g, Chinese yam 25g ~ 35g, moutan bark 20g ~ 30g, RADIX ACONITILATERALIS PREPARATA 10g ~ 20g, paniculate spotflower herb 15g ~ 25g, honey-fried licorice root 20g ~ 30g, awns beanstalk bone 10g ~ 20g, entire micromelum root-brak or leaf 15g ~ 25g, mountain eel grass 10g ~ 20g and sweet clover 15g ~ 25g.
Wherein, in described drug powder, the weight of each bulk drug is respectively barrenwort 23g ~ 27g, sealwort 28g ~ 32g, Gorgon fruit 18g ~ 22g, Chinese ephedra 13g ~ 17g, Centipeda minima 23g ~ 27g, semen astragali complanati 28g ~ 32g, capsule of weeping forsythia 18g ~ 22g, Companumoea root 38g ~ 42g, water Cape jasmine 13g ~ 17g, Chinese yam 28g ~ 32g, moutan bark 23g ~ 27g, RADIX ACONITILATERALIS PREPARATA 13g ~ 17g, paniculate spotflower herb 18g ~ 22g, honey-fried licorice root 23g ~ 27g, awns beanstalk bone 13g ~ 17g, entire micromelum root-brak or leaf 18g ~ 22g, mountain eel grass 13g ~ 17g and sweet clover 18g ~ 22g.
Present invention also offers the preparation method of above-mentioned feed, be specially:
The first step, preparation said medicine powder;
Second step, the drug powder first step obtained and salt, zinc methionine, lysine, dehydroretinol, vitamin E2 and ethoxyquinoline are by above-mentioned weight Homogeneous phase mixing, incorporation time is 2 ~ 3 minutes, diameter 1 ~ 3mm particle is made by granulator, vacuum drying at 45 ~ 55 DEG C of granulating after mixing;
3rd step, corn, dregs of beans, fish meal are taken out according to above-mentioned weight and mix rear pulverizing, mixed by the raw material crushed, incorporation time is 4 ~ 5 minutes, makes diameter 1 ~ 3mm particle, then vacuum drying at 45 ~ 55 DEG C by granulator;
4th step, the particle that the particle made by second step and the 3rd step are made mixes, and incorporation time is 4 ~ 5 minutes, obtains particulate material finished product.
Wherein, the described first step is specially further to be pulverized respectively by each bulk drug component, sends into stirrer for mixing by weight even, every 100g mixture, adds the water of 500g ~ 600g, boils 3 ~ 4 hours, filter, obtain the first filtrate, the filter residue that 100g mixture obtains adds the water of 200g ~ 300g again, again boil 1 ~ 2 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverizes, drying, obtains dry powder.
Beneficial effect of the present invention:
The features such as the medicine for preventing and treating porcine reproductive and respiratory syndrome provided by the invention is poisoned little to animal, and medicament residue is few, have more obvious advantage in anti-reproductive and respiratory syndrome processed.
Detailed description of the invention
Theory of traditional Chinese medical science is thought, though the generation of porcine reproductive and respiratory syndrome and change intricate, be attributed to 2 points, i.e. body internal factor and the interactional result of external factor.Traditional Chinese veterinary medicine thinks that this is the result that (healthy tendency) struggles against with (perverse trend).(healthy tendency) is the functional activity of each internal organs organ of livestock and poultry body, and the adaptive capacity of its environment to external world, to the resistivity of paathogenic factor, rehabilitation ability, it is the identification foreign matter based on the material such as function and qi-blood-body fluid, get rid of foreign matter, maintain self homeostasis and stable function.(perverse trend) refers to the extraneous six external factors which cause diseases, the gas of epidemic disease, comprises again pathological change that body imbalance of yin and yang produces and pathological product etc.Whether the health of body depends on the power of (healthy tendency) and (perverse trend), from traditional Chinese veterinary medicine angle analysis, belongs to Epidemic Febrile Disease, and its morbidity at pig body changes available three Jiao, and the part of the body cavity above the diaphragm housing the heart and lungs, middle Jiao, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, defensive-qi-nutrient-blood carrys out diagnosis and treatment.(empty evil mutual aid) is predisposing factors, and when the five internal organs that namely traditional Chinese medical science is said are in (void), virus is taken advantage of a weak point, and cause pathogen being excessive but vital QI weak, disease-resistant unable, this disease is multiple for summer.Many because of diseases caused by external factors damp and hotization fire, cause Lung Qi obstruction, disturbance in ascending and descending, caused by imbalance of yin and yang.The immune system of modern medicine has defence, from hidden and supervision 3 large functions.Defence refers to the infection resisting various pathogenic microorganism, and the outer evil effect of traditional Chinese veterinary medicine healthy tendency defence similarly; From hidden just refer to remove autoantigen, get rid of extrinsic factor ten disturb, stablize environment, maintenance immunologic balance; Immunosurveillance is in case stop machine somatic mutation is " alien elements ", and pass through immunological rejection, repel these " alien elementses ", traditional Chinese veterinary medicine healthy tendency coordinate the interdependence of zang-fu differentiation qi and blood, mutually restriction, remove in evil, re-establish the effect of equilibrium between yin and yang also similarly.It can thus be appreciated that the said carcass healthy tendency of traditional Chinese veterinary medicine, have the immune identity function of modern veterinary science, immune organ, tissue, cell may be exactly the material foundation of tcm of healthy tendency, and the process of struggling between the vital energy and the pathogenic factor is exactly immunoreactive process.Therefore, the generation of whole disease, development and change, be all reaction of " healthy tendency " and " perverse trend " struggle mutually, good and evil struggle runs through disease progression all the time, therefore, in line with strengthening vital QI to eliminate pathogenic factors in treatment, the principle of giving consideration to both the incidental and fundamental.
Based on this, the invention provides a kind of medicine being used for the treatment of porcine reproductive and respiratory syndrome, its bulk drug comprises barrenwort, sealwort, Gorgon fruit, Chinese ephedra, Centipeda minima, semen astragali complanati, the capsule of weeping forsythia, Companumoea root, water Cape jasmine, Chinese yam, moutan bark, RADIX ACONITILATERALIS PREPARATA, paniculate spotflower herb, honey-fried licorice root, awns beanstalk bone, entire micromelum root-brak or leaf, mountain eel grass and sweet clover.
Further preferably, described medicine is only prepared from by above-mentioned raw materials medicine.
In described medicine, the weight of each bulk drug is respectively barrenwort 20g ~ 30g, sealwort 25g ~ 35g, Gorgon fruit 15g ~ 25g, Chinese ephedra 10g ~ 20g, Centipeda minima 20g ~ 30g, semen astragali complanati 25g ~ 35g, capsule of weeping forsythia 15g ~ 25g, Companumoea root 35g ~ 45g, water Cape jasmine 10g ~ 20g, Chinese yam 25g ~ 35g, moutan bark 20g ~ 30g, RADIX ACONITILATERALIS PREPARATA 10g ~ 20g, paniculate spotflower herb 15g ~ 25g, honey-fried licorice root 20g ~ 30g, awns beanstalk bone 10g ~ 20g, entire micromelum root-brak or leaf 15g ~ 25g, mountain eel grass 10g ~ 20g and sweet clover 15g ~ 25g.
Further preferably, in described medicine, the weight of each bulk drug is respectively barrenwort 23g ~ 27g, sealwort 28g ~ 32g, Gorgon fruit 18g ~ 22g, Chinese ephedra 13g ~ 17g, Centipeda minima 23g ~ 27g, semen astragali complanati 28g ~ 32g, capsule of weeping forsythia 18g ~ 22g, Companumoea root 38g ~ 42g, water Cape jasmine 13g ~ 17g, Chinese yam 28g ~ 32g, moutan bark 23g ~ 27g, RADIX ACONITILATERALIS PREPARATA 13g ~ 17g, paniculate spotflower herb 18g ~ 22g, honey-fried licorice root 23g ~ 27g, awns beanstalk bone 13g ~ 17g, entire micromelum root-brak or leaf 18g ~ 22g, mountain eel grass 13g ~ 17g and sweet clover 18g ~ 22g.
Most preferably, in described medicine, the weight of each bulk drug is respectively barrenwort 25g, sealwort 30g, Gorgon fruit 20g, Chinese ephedra 15g, Centipeda minima 25g, semen astragali complanati 30g, capsule of weeping forsythia 20g, Companumoea root 40g, water Cape jasmine 15g, Chinese yam 30g, moutan bark 25g, RADIX ACONITILATERALIS PREPARATA 15g, paniculate spotflower herb 20g, honey-fried licorice root 25g, awns beanstalk bone 15g, entire micromelum root-brak or leaf 20g, mountain eel grass 15g and sweet clover 20g.
Present invention also offers the preparation method of said medicine, be specially and each bulk drug component is pulverized respectively, send into stirrer for mixing by weight even, every 100g mixture, adds the water of 500g ~ 600g, boils 3 ~ 4 hours, filter, obtain the first filtrate, the filter residue that 100g mixture obtains adds the water of 200g ~ 300g again, again boil 1 ~ 2 hour, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverizes, drying, obtains dry powder.
Each bulk drug pharmacology is as follows:
Barrenwort: latin name EpimediiFolium, taste is pungent, sweet, warm in nature, enters liver, kidney channel, has kidney-replenishing, strengthening the bones and muscles, effect of wines used as antirheumatic, cures mainly impotence due to deficiency of the kidney, premature ejaculation of passing out semen, waist knee impotence are soft, cold extremities with aversion to cold; The cards such as numbness and ache of cold dampness or spasm of limbs numbness.
Sealwort: latin name PolygonatiRhizoma, taste is sweet, and property is put down, enter lung, spleen, kidney channel, there is enriching qi and yin, invigorating the spleen moistening lung, effect of enriching kidney essence, for taste deficiency of qi and yin, food is few unable, the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Gorgon fruit: taste is sweet, puckery, property is put down.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen antidiarrheal, the function that clearing damp is only with, cure mainly emission, splenasthenic diarrhea, insufficiency of the spleen gonorrhoea, be with inferior card.
Chinese ephedra: pungent, the micro-hardship of taste, warm in nature, enter lung, urinary bladder channel, have and send out cold inducing sweat, freeing lung and relieving asthma, the effect of inducing diuresis for removing edema, is mainly used in the superficies excess syndromes such as the fever without perspiration of catching cold; Rheumatic numbness pain; Pathogenic cold attacking the lung or accumulation of heat in the lung are to coughing the cards such as inverse, oedema, difficult urination of breathing.
Centipeda minima: taste is pungent, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, cough-relieving apophlegmatic, the effect of eliminating stasis to subdue swelling, for exterior syndrome due to wind-cold, nasal obstruction runny nose and nasosinusitis, coughing with a lot of sputum, pertussis, the cards such as sore, carbuncle and painful swelling.
Semen astragali complanati: warm in nature, taste is sweet, has warm filling liver kidney, controlling nocturnal emission with astringent drugs, contracting urine, the effect of improving eyesight, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, frequent micturition, or leukorrhea, soreness and weakness of waist and knees, pain in the back; Kidney deficiency and liver, blurred vision order is dark, the cards such as hypopsia.
The capsule of weeping forsythia: bitter, cold nature, enters the heart, liver, courage, small intestinl channel, has clearing heat and detoxicating, effect of dispersing swelling and dissipating binds, for ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease from the beginning of, warmly join the army, high hot polydipsia, coma sends out spot, and heat drenches the cards such as renal shutdown.
Companumoea root: latin name radixcampanumoeajavanicae, be the root of Campanulaceae leopard platymiscium Campanumoea javanica and leopard, taste is sweet, property is put down, and returns lung, the spleen channel, has strengthening the spleen and replenishing qi, tonifies the lung to relieve cough, effect of lactogenesis, cure mainly the empty internal injury of labor, the deficiency of vital energy is weak, palpitaition, hidrosis, splenasthenic diarrhea, leukorrhea, milk is rare, the cards such as insufficiency of the spleen cough.
Water Cape jasmine: be the fruit of Rubiaceae Gardenia Ellis plant great Hua cape jasmine, bitter, cold in nature, have clearing heat and detoxicating, effect of swelling and pain relieving, cure mainly heat poison, jaundice, nephritic dropsy, dampen cards such as spraining.
Chinese yam: latin name dioscoreaerhizoma, taste is sweet, property is flat, and enter lung, spleen, stomach warp, have tonifying spleen nourishing the stomach, beneficial lung reinforces the kidney, and the effect of nourishing Yin and promoting production of body fluid cures mainly weakness of the spleen and the stomach, and the cards such as difference, the vexed diarrhoea of gastral cavity received less by the food of the dysfunction of the spleen in transport.
Moutan bark: latin name MoutanCortex, bitter, pungent, cold nature, enters the heart, liver, kidney channel, has clearing heat and cooling blood, effect promoting blood circulation and removing blood stasis, for the card such as fever due to yin deficiency, the acute appendicitis of damp and hot knot poison, depressed blood stasis, dry, deep red tongue of excessive noxious heat; And irascibility red eye, swell pain, stomach fire gum pain.
RADIX ACONITILATERALIS PREPARATA: taste is pungent, sweet, extremely hot in nature, the thoughts of returning home, kidney, the spleen channel.Have recuperating depleted yang, mend fire supporing yang, effect of eliminating cold to stop pain, cure mainly yang depletion collapse, the cold weak pulse of limb, deficiency of heart-YANG, chest impediment and cardialgia, the cold of insufficiency type is vomited and diarrhoea, and coldness and pain in the epigastrium, decline of kidney-YANG, impotence palace is cold, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, the cards such as numbness and ache of cold dampness.
Paniculate spotflower herb: warm in nature, taste is pungent, nontoxic, detoxification and promoting urination, relieving cough and relieving asthma, swelling and pain relieving.For malaria, toothache, enteritis, dysentery, cough, asthma, pertussis, pulmonary tuberculosis, the cards such as venomous snake bite is controlled in external application, dog bite, carbuncle furuncle.
Honey-fried licorice root: taste is sweet, property put down, enter 12 warps, be in harmonious proportion the property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and in, relieving spasm to stop pain, is mainly used in invigorating the spleen and benefiting qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
Awns beanstalk bone: be spire, the petiole of Li Baikemang beanstalk platymiscium awns beanstalk, mildly bitter flavor, puckery, cool in nature, there is removing blood stasis and hemostasis, effect of inducing diuresis to reduce edema, cures mainly metrorrhagia, traumatic injury, traumatism and bleeding, and heat drenches puckery pain, leukorrhea, baby diarrhea, red eye, swell pain, burn and scald, the cards such as insect-bite.
Entire micromelum root-brak or leaf: be the root of Rutaceae entire micromelum root-brak or leaf platymiscium entire micromelum root-brak or leaf, bark and leaf, bitter, pungent, warm in nature, have and dispel rheumatism, promoting the circulation of qi is fallen apart effect of the stasis of blood, cures mainly influenza, cold cough, stomachache, arthralgia due to wind-dampness, treating swelling and pain by traumatic injury, the cards such as fracture.
Mountain eel grass: be the herb of Labiatae bugle ajuga nipponensis Makino, bitter, cold in nature, have the flat liver of heat-clearing, effect of eliminating inflammation and expelling toxin, cures mainly chronic hepatitis, urinary tract infections, stomatitis, the cards such as sore swollen toxin.
Sweet clover: taste is pungent, property is put down, and have and middle stomach invigorating, clearing away heat and eliminating dampeness, effect of diuresis, cures mainly summer-heat and damp uncomfortable in chest, and mouth is greasy, halitosis, dysentery, the cards such as gonorrhoea.
Present invention also offers a kind of for preventing the feed of porcine reproductive and respiratory syndrome, its raw material comprises drug powder, corn, dregs of beans, salt, fish meal, zinc methionine, lysine, vitamin A, vitamin C and ethoxyquinoline for preventing and treating porcine reproductive and respiratory syndrome.
Further preferably, described feed is only made up of above-mentioned raw materials.
Wherein, in described feed, the weight portion of each raw material is respectively drug powder 3 weight portion ~ 5 weight portion, corn 250 weight portion ~ 300 weight portion, dregs of beans 120 weight portion ~ 160 weight portion, salt 3 weight portion ~ 5 weight portion, fish meal 25 weight portion ~ 35 weight portion, zinc methionine 0.5 weight portion ~ 1.5 weight portion, lysine 0.5 weight portion ~ 1.5 weight portion, retinol1 weight portion ~ 2 weight portion, vitamin e1 weight portion ~ 2 weight portion, ethoxyquinoline 2 weight portion ~ 4 weight portion for preventing and treating porcine reproductive and respiratory syndrome.
Further preferably, in described feed, the weight portion of each raw material is respectively drug powder 4 weight portion, corn 280 weight portion, dregs of beans 150 weight portion, salt 4 weight portion, fish meal 30 weight portion, zinc methionine 1 weight portion, lysine 1 weight portion, dehydroretinol weight portion, vitamin E2 weight portion, ethoxyquinoline 3 weight portion for preventing and treating porcine reproductive and respiratory syndrome.
Present invention also offers the preparation method of above-mentioned feed, be specially:
The first step, preparation said medicine powder;
Second step, the drug powder first step obtained and salt, zinc methionine, lysine, dehydroretinol, vitamin E2 and ethoxyquinoline are by above-mentioned weight Homogeneous phase mixing, incorporation time is 2 ~ 3 minutes, diameter 1 ~ 3mm particle is made by granulator, vacuum drying at 45 ~ 55 DEG C of granulating after mixing;
3rd step, corn, dregs of beans, fish meal are taken out according to above-mentioned weight and mix rear pulverizing, mixed by the raw material crushed, incorporation time is 4 ~ 5 minutes, makes diameter 1 ~ 3mm particle, then vacuum drying at 45 ~ 55 DEG C by granulator;
4th step, the particle that the particle made by second step and the 3rd step are made mixes, and incorporation time is 4 ~ 5 minutes, obtains particulate material finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 drug powder 1
By barrenwort 25g, sealwort 30g, Gorgon fruit 20g, Chinese ephedra 15g, Centipeda minima 25g, semen astragali complanati 30g, capsule of weeping forsythia 20g, Companumoea root 40g, water Cape jasmine 15g, Chinese yam 30g, moutan bark 25g, RADIX ACONITILATERALIS PREPARATA 15g, paniculate spotflower herb 20g, honey-fried licorice root 25g, awns beanstalk bone 15g, entire micromelum root-brak or leaf 20g, mountain eel grass 15g and sweet clover 20g pulverizes respectively, feeding stirrer for mixing is even, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, the filter residue that 100g mixture obtains adds the water of 300g again, again boil 2 hours, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverize, dry, obtain dry powder.
Pharmacology acute toxicity test
Animal used as test: SPF level, kunming mice, 40,20 ± 2g, male and female half and half, are provided by Qingdao Agricultural University's animal experimental center.
Test medicine: experimental group: drug powder 1 prepared by the embodiment of the present invention 1, water-soluble solution is made into the solution of crude drug content 1.75g/ml, and 4 DEG C save backup.Control group: gavage physiological saline, all the other conditions are with medicine group of the present invention.
Experimental technique
Grouping: get SPF level, kunming mice 40, male and female half and half, raise in Qingdao Agricultural University's animal experimental center, adaptability is raised one week.By table of random numbers method, mouse being divided into 2 groups, is control group 20 respectively, experimental group 20, male and female half and half, sub-cage rearing.
Medication
Before experiment, the fasting of each group mouse can't help water 12h, control group gavage distilled water 0.2ml/20g body weight, 3 times/day, experimental group, drug powder 1,0.2ml/20g body weight prepared by the gavage embodiment of the present invention 1,3 times/day, dosing interval 4h.Successive administration 7 days, drug withdrawal observes 3 days.
Observation index
Ordinary circumstance: observe during administration and drug withdrawal viewing duration, the ordinary circumstance of each group mouse, as developmental state (body temperature, body weight, heart rate), coat condition, the state of mind, each natural hole situation, autonomic activities situation.
Internal organs check and Physico-chemical tests: experimentally requirement, occurs animal dead during administration, dissects immediately, observes each internal organs situation, peels off each internal organs, weigh, and calculate organ index, heart extracting blood Physico-chemical tests; As nothing is dead, then experimentally requirement, after the observation period, gives 10% chloral hydrate anesthesia, opens abdominal cavity, observes each internal organs situation, and abdominal aortic blood is put to death, and does Physico-chemical tests, peels off each internal organs, weigh, and calculate organ index.
Result
Experimental session, without dead mouse, experimentally arranges to carry out coherent detection.
Ordinary circumstance
During administration and drug withdrawal viewing duration, each group mouse at the baseline signs such as body weight, body temperature, Non Apparent Abnormality, two groups are compared, no difference of science of statistics, outward appearance is normal, without deformity, fur color and luster is normal, the state of mind is good, and each natural hole is clean, secretion without exception, autonomic activities is normal, behavior without exception.
Internal organs check and Physico-chemical tests
Experimentally requirement, after the observation period, gives 10% chloral hydrate anesthesia, and abdominal aortic blood is put to death, open abdominal cavity, observe each internal organs situation, the arrangement of each group mice organs is normal, without adhesion, without hemorrhage, blood of getting does Physico-chemical tests, each group of Mouse Blood routine is without exception, and liver function, kidney merit check without exception, peel off each internal organs, weigh, calculate organ index, through statistical analysis, no difference of science of statistics, two groups of same periods compare, statistics indifference.
Conclusion
By acute toxicity test in mice, mouse dosage is 52.5g/kg/d, and without obvious toxic-side effects, can think that medicine is safe.Can be confirmed by this experiment, Chinese medicine of the present invention, in acute toxicity test, without acute toxic reaction, without delayed toxicity, can be thought safe substantially.
Long term toxicity test
Animal used as test: SPF level, kunming mice, 40,20 ± 2g, male and female half and half, are provided by Qingdao Agricultural University's animal experimental center.
Test medicine
Experimental group: drug powder 1 prepared by the embodiment of the present invention 1, water-soluble solution is made into the solution of crude drug content 1.15g/ml, 0.85g/ml, 0.55g/ml, and 4 DEG C save backup.Control group: gavage physiological saline, all the other conditions are with medicine group of the present invention.
Experimental technique
Grouping
Get SPF level, kunming mice 40, male and female half and half, raise in Qingdao Agricultural University's animal experimental center, adaptability is raised one week.By table of random numbers method, mouse being divided into 2 groups, is control group 10, high dose group 10, middle dosage group 10, low dose group 10 respectively, male and female half and half, sub-cage rearing.
Medication
Before experiment, the fasting of each group mouse can't help water 12h, control group gavage distilled water 0.2ml/20g body weight, 2 times/day, high, medium and low dosage group, drug powder 1.0g/ml, 0.75g/ml, 0.5g/ml of the gavage embodiment of the present invention 1 preparation respectively, 0.2ml/20g body weight, 2 times/day, dosing interval 6h.Successive administration 14 days, drug withdrawal observes 7 days.
Observation index
Ordinary circumstance
Observe during administration and drug withdrawal viewing duration, the ordinary circumstance of each group mouse, as developmental state (body temperature, body weight, heart rate), coat condition, the state of mind, each natural hole situation, autonomic activities situation.
Internal organs check and Physico-chemical tests
, there is animal dead during administration in experimentally requirement, dissects immediately, observes each internal organs situation, peel off each internal organs, weigh, and calculate organ index, heart extracting blood Physico-chemical tests; As nothing is dead, then experimentally requirement, after the observation period, gives 10% chloral hydrate anesthesia, opens abdominal cavity, observes each internal organs situation, and abdominal aortic blood is put to death, and does Physico-chemical tests, peels off each internal organs, weigh, and calculate organ index.
Result
Experimental session, without dead mouse, experimentally arranges to carry out coherent detection.
Ordinary circumstance
During administration and drug withdrawal viewing duration, each group mouse at the baseline signs such as body weight, body temperature, Non Apparent Abnormality, two groups are compared, no difference of science of statistics, outward appearance is normal, without deformity, fur color and luster is normal, the state of mind is good, and each natural hole is clean, secretion without exception, autonomic activities is normal, behavior without exception.
Internal organs check and Physico-chemical tests
Experimentally requirement, after the observation period, gives 10% chloral hydrate anesthesia, and abdominal aortic blood is put to death, open abdominal cavity, observe each internal organs situation, the arrangement of each group mice organs is normal, without adhesion, without hemorrhage, blood of getting does Physico-chemical tests, each group of Mouse Blood routine is without exception, and liver function, kidney merit check without exception, peel off each internal organs, weigh, calculate organ index, through statistical analysis, no difference of science of statistics, two groups of same periods compare, statistics indifference.
Conclusion
Can be confirmed by this experiment, Chinese medicine of the present invention, in long term toxicity test, without cumulative toxicity, without delayed toxicity, substantially can think safe, therefore Clinical practice is safe.
Embodiment 2 drug powder 2
By barrenwort 23g, sealwort 28g, Gorgon fruit 18g, Chinese ephedra 13g, Centipeda minima 23g, semen astragali complanati 28g, capsule of weeping forsythia 18g, Companumoea root 38g, water Cape jasmine 13g, Chinese yam 28g, moutan bark 23g, RADIX ACONITILATERALIS PREPARATA 13g, paniculate spotflower herb 18g, honey-fried licorice root 23g, awns beanstalk bone 13g, entire micromelum root-brak or leaf 18g, mountain eel grass 13g and sweet clover 18g pulverizes respectively, feeding stirrer for mixing is even, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, the filter residue that 100g mixture obtains adds the water of 300g again, again boil 2 hours, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverize, dry, obtain dry powder.
Embodiment 3 drug powder 3
By barrenwort 27g, sealwort 32g, Gorgon fruit 22g, Chinese ephedra 17g, Centipeda minima 27g, semen astragali complanati 32g, capsule of weeping forsythia 22g, Companumoea root 42g, water Cape jasmine 17g, Chinese yam 32g, moutan bark 27g, RADIX ACONITILATERALIS PREPARATA 17g, paniculate spotflower herb 22g, honey-fried licorice root 27g, awns beanstalk bone 17g, entire micromelum root-brak or leaf 22g, mountain eel grass 17g and sweet clover 22g pulverizes respectively, feeding stirrer for mixing is even, every 100g mixture, add the water of 600g, boil 4 hours, filter, obtain the first filtrate, the filter residue that 100g mixture obtains adds the water of 300g again, again boil 2 hours, filter, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverize, dry, obtain dry powder.
Embodiment 4 feed 1
Drug powder 400g prepared by embodiment 1, salt 400g, zinc methionine 100g, lysine 100g, dehydroretinol 00g, vitamin E2 00g, ethoxyquinoline 300g Homogeneous phase mixing, incorporation time is 3 minutes, diameter 3mm particle is made by granulator after mixing, granulation vacuum drying at 55 DEG C, by corn 28kg, dregs of beans 15kg, fish meal 3kg mixes rear pulverizing, the raw material crushed is mixed, incorporation time is 5 minutes, diameter 2mm particle is made by granulator, then vacuum drying at 50 DEG C, the particle made above is mixed, incorporation time is 5 minutes, obtain particulate material finished product.
Comparative example 1 feed 2
By barrenwort 25g, sealwort 40g, Gorgon fruit 30g, Chinese ephedra 15g, Centipeda minima 20g, semen astragali complanati 25g, capsule of weeping forsythia 35g, Companumoea root 30g, water Cape jasmine 20g, Chinese yam 25g, moutan bark 20g, wilsonii 35g, white thizoma curculiginis 15g, amplexicaul jasmine leaf 15g, bunge bedstraw herb 20g, manyleaf meadowure rhizome and root 15g, parasitic loranthus 30g, franzenbach rhubarb root and rhizome 20g, adenophora tetraphylla 25g and intelligence development 15g is crushed to 40 orders respectively, mixes, and then puts it into volume and is 10 times of medicinal material amount and volumetric concentration is in the ethanolic solution of 90%, adopt reflux extraction, extract 3 times, each extraction time is 2h, Extracting temperature is 75 DEG C, will extract solution mixing, filtering and collecting filter liquid, is placed on Rotary Evaporators concentrated, and removing alcohol solvent, dry, pulverize, adaptive immune preparation, the immune formulation 30g this prepared and calcium monohydrogen phosphate 20g, salt 10g, the excellent profit of composite additive of trace elements protects 2g, the plain 5g of the excellent dimension of compound vitamin additive, lysine 1g and methionine 1g Homogeneous phase mixing, incorporation time is 3 minutes, makes diameter 2mm particle after mixing by granulator, and vacuum drying at 50 DEG C of granulating, by corn 550g, dregs of beans 100g, fish meal 80g, wheat 130g mixes rear pulverizing, is mixed by the raw material crushed, and incorporation time is 5 minutes, make diameter 2mm particle by granulator, then vacuum drying at 50 DEG C, the particle made above is mixed, incorporation time is 5 minutes, obtains particulate material finished product.
Antivirus test
Main agents and instrument
Cell growth medium, low sugar DMEM, CIBCO product, adds 10% newborn calf serum (the general marine growth Co., Ltd in Qingdao), every 100ml nutrient solution add 10000IU penicillin and streptomysin.
Cell maintenance medium, except newborn calf serum is except 2%, all the other same cell growth mediums.
MTT, 3-(4,6-dimethylthiazole-2-xl)-2,5-ethylbenzenes-Thiazolyl blue tetrazolium bromide salt, Amresco Products.
Dimethyl sulfoxide (DMSO) (DMSO), analyzes pure, Shanghai Ling Feng chemical reagent Co., Ltd product.
DC3022 type enzyme-linked immunosorbent assay instrument, state-run East China Electronics Co., Ltd pipe factory product.
Medicine prepares
Drug powder 1 prepared by embodiment 1, be dissolved in water to crude drug content 60mg/ml, 0.22 μm of filtering with microporous membrane is degerming.Measuring the maximum safe concentration of Marc-145 cell through trial test is 6.0mg/ml, and become 6000,1500,375, a 93.75 μ g/ml4 concentration with cell maintenance medium 4 doubling dilution, 4 DEG C save backup.
Virus prepares
Porcine reproductive and respiratory syndrome virus, the preservation of-20 DEG C, this laboratory, before use 37 DEG C thaw after, be diluted to 100TCID with cell maintenance medium
50for subsequent use.
Test method
96 orifice plates are inoculated Marc-145 cell, cultivate 24h and formed after individual layer, adopt respectively to add virus after first adding medicine, first add virus after add medicine, medicine and virus incubation after add 3 kinds of modes.Namely first add medicine, after hatching 2h, add virus liquid; First add virus, remove virus liquid after hatching 2h and add medicine again; Cell is joined after medicine and virus incubation 2h.Continue to cultivate 72h, measure each hole OD by MTT absorption process enzyme-linked immunosorbent assay instrument
570value, as the index of medicine antagonism virus infected cell.OD value is larger, and antiviral effect is better.
Data processing
Measurement data adopts
represent, compare between group and adopt χ
2inspection, all data all adopt the process of SPSS12.0 statistical software.
Result
Effect (the OD of table 1 Chinese medicine opposing porcine reproductive and respiratory syndrome virus infection cell
570value)
Can be found out by table 1, Chinese medicine of the present invention has good preventive and therapeutic action to porcine reproductive and respiratory syndrome virus, and along with drug concentration higher, effect is better.
Prevention effect is tested
Test material: feed 1 prepared by embodiment 4 and feed 2 prepared by comparative example 1.
Experimental animal
In May, 2014, the child care pig on multiple pig farm, somewhere, Qingdao, there is expiratory dyspnea (abdominal respiration) in various degree in cluster, spirit is depressed, drowsiness, the situations such as poor appetite, and severe patient is coughed, and pants, respiratory rate up to 80 times/more than min, ear! The symptoms such as belly and leg cyanosis.Cut open the visible stethemia of the sick pig of inspection, occur oedema, focal pneumonia; What have has the symptom such as pleural effusion, enlargement of hilar lymph nodes.Once used multiple drug therapy as sulphadiazine clinically, penicillin and streptomycin etc. are showed no effect, and swinery carried out the immunity of swine fever, pig blue-ear disease and streptococcosis.
Laboratory examination
The extraction of pathological material of disease total serum IgE
Get serum 0.25ml and add 1mlTrizol reagent, incubated at room 5min, add 0.2ml chloroform, fully rock centrifuge tube 15s, incubated at room 2-3min, 4 DEG C, the centrifugal 15min of 12000r/min, transfer supernatant is in another new 1.5ml centrifuge tube, add 0.5ml isopropyl alcohol, fully rock, place 4 DEG C, the centrifugal 10min of 12000r/min, precipitate nucleic acids, abandon supernatant, add 75% ethanol 1ml and jolt, washing nucleic acid, 4 DEG C, the centrifugal 5min of 8000r/min, abandon supernatant, drying at room temperature precipitation 5min, adds the water-soluble solution sediment of 40 μ lDEPC.
Reverse transcription
Get downstream primer GP5.20.5 μ l, 10mmol/ldNTPs0.25 μ l, 5 × reverse transcription buffer2.0 μ l and total serum IgE 7.0 μ l, 65 DEG C of water-bath 10min, then add M-MLV reverse transcriptase 0.25 μ l, mend to cumulative volume 10.0 μ l, 37 DEG C of water-bath 1h with aseptic double-distilled water.
PCR
Reaction cumulative volume 25 μ l.Upstream primer GP5.10.5 μ l, downstream primer GP5.20.5 μ l, 2.5mmol/ldNTPs2.0 μ l, 10 × Mg
2+freebuffer2.5 μ l, 2.5mmol/lMg
2+1.5 μ l, rTap enzyme 2.5U, CDNA1 μ l, mend to cumulative volume 25 μ l with sterilizing distilled water.Reaction cycle parameter, 94 DEG C of denaturation 5min; 94 DEG C of sex change 45s, 59 DEG C of annealing 45s, 72 DEG C extend 60s, carry out 35 circulations altogether; Then 72 DEG C extend 10min.Get PCR primer and carry out 2% agarose gel electrophoresis.
RT-PCR testing result
10 parts of blood serum sample results are all positive, and according to clinical symptoms, cut open inspection change and results of serological detection, being diagnosed as main pathogen is porcine reproductive and respiratory syndrome virus.
GP TH
Get 600 sick pigs and be divided into 3 groups, put into 3 respectively and clean up and the isolating pig house of sterilizing.Feed group 200, the feed adopting the embodiment of the present invention 4 to provide carries out feeding; Blank group 200 does not give any medicine, feeding conventional corn feed; Feed 2 prepared by positive controls 200 feeding comparative examples 1.Three groups of equal feedings 7 days.
Efficacy determination
Observe the spirit of pig, search for food, body temperature, breathing, skin and the situation such as ear color and death, judge curative effect by following standard.
Cure: breathe steadily after medication, spirit, diet, body temperature, skin and ear color recover normal.
Take a turn for the better: after medication, symptom obviously alleviates, breathing, spirit, body temperature, diet take a turn for the better.
Invalid: after medication, symptom does not alleviate, even increase the weight of or death.
Total effective rate=cure rate+improvement rate.
Result
Three groups of comparitive study, the results are shown in Table 2.
Table 2 three groups of comparitive study
As can be seen from Table 2, the feed containing Chinese medicine provided by the invention is adopted to treat porcine reproductive and respiratory syndrome, and compared with the achievement in research before inventor, better effects if, significant difference.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. for preventing and treating a feed for porcine reproductive and respiratory syndrome, it is characterized in that: raw material comprises drug powder, corn, dregs of beans, salt, fish meal, zinc methionine, lysine, vitamin A, vitamin C and ethoxyquinoline for preventing and treating porcine reproductive and respiratory syndrome.
2. as claimed in claim 1 for preventing and treating the feed of porcine reproductive and respiratory syndrome, it is characterized in that: in described feed, the weight portion of each raw material is respectively drug powder 3 weight portion ~ 5 weight portion for preventing and treating porcine reproductive and respiratory syndrome, corn 250 weight portion ~ 300 weight portion, dregs of beans 120 weight portion ~ 160 weight portion, salt 3 weight portion ~ 5 weight portion, fish meal 25 weight portion ~ 35 weight portion, zinc methionine 0.5 weight portion ~ 1.5 weight portion, lysine 0.5 weight portion ~ 1.5 weight portion, retinol1 weight portion ~ 2 weight portion, vitamin e1 weight portion ~ 2 weight portion, ethoxyquinoline 2 weight portion ~ 4 weight portion.
3. as claimed in claim 1 or 2 for preventing and treating the feed of porcine reproductive and respiratory syndrome, it is characterized in that: in described feed, the weight portion of each raw material is respectively drug powder 4 weight portion, corn 280 weight portion, dregs of beans 150 weight portion, salt 4 weight portion, fish meal 30 weight portion, zinc methionine 1 weight portion, lysine 1 weight portion, dehydroretinol weight portion, vitamin E2 weight portion, ethoxyquinoline 3 weight portion for preventing and treating porcine reproductive and respiratory syndrome.
4. the feed for preventing and treating porcine reproductive and respiratory syndrome as described in claims 1 to 3, is characterized in that: the bulk drug of described drug powder comprises barrenwort, sealwort, Gorgon fruit, Chinese ephedra, Centipeda minima, semen astragali complanati, the capsule of weeping forsythia, Companumoea root, water Cape jasmine, Chinese yam, moutan bark, RADIX ACONITILATERALIS PREPARATA, paniculate spotflower herb, honey-fried licorice root, awns beanstalk bone, entire micromelum root-brak or leaf, mountain eel grass and sweet clover.
5. the feed for preventing and treating porcine reproductive and respiratory syndrome as described in Claims 1-4, it is characterized in that: in described drug powder, the weight of each bulk drug is respectively barrenwort 20g ~ 30g, sealwort 25g ~ 35g, Gorgon fruit 15g ~ 25g, Chinese ephedra 10g ~ 20g, Centipeda minima 20g ~ 30g, semen astragali complanati 25g ~ 35g, capsule of weeping forsythia 15g ~ 25g, Companumoea root 35g ~ 45g, water Cape jasmine 10g ~ 20g, Chinese yam 25g ~ 35g, moutan bark 20g ~ 30g, RADIX ACONITILATERALIS PREPARATA 10g ~ 20g, paniculate spotflower herb 15g ~ 25g, honey-fried licorice root 20g ~ 30g, awns beanstalk bone 10g ~ 20g, entire micromelum root-brak or leaf 15g ~ 25g, mountain eel grass 10g ~ 20g and sweet clover 15g ~ 25g.
6. the feed for preventing and treating porcine reproductive and respiratory syndrome as described in claim 1 to 5, it is characterized in that: in described drug powder, the weight of each bulk drug is respectively barrenwort 23g ~ 27g, sealwort 28g ~ 32g, Gorgon fruit 18g ~ 22g, Chinese ephedra 13g ~ 17g, Centipeda minima 23g ~ 27g, semen astragali complanati 28g ~ 32g, capsule of weeping forsythia 18g ~ 22g, Companumoea root 38g ~ 42g, water Cape jasmine 13g ~ 17g, Chinese yam 28g ~ 32g, moutan bark 23g ~ 27g, RADIX ACONITILATERALIS PREPARATA 13g ~ 17g, paniculate spotflower herb 18g ~ 22g, honey-fried licorice root 23g ~ 27g, awns beanstalk bone 13g ~ 17g, entire micromelum root-brak or leaf 18g ~ 22g, mountain eel grass 13g ~ 17g and sweet clover 18g ~ 22g.
7. the preparation method of feed described in claim 1 to 6, is characterized in that:
The first step, preparation said medicine powder;
Second step, the drug powder first step obtained and salt, zinc methionine, lysine, dehydroretinol, vitamin E2 and ethoxyquinoline are by above-mentioned weight Homogeneous phase mixing, incorporation time is 2 ~ 3 minutes, diameter 1 ~ 3mm particle is made by granulator, vacuum drying at 45 ~ 55 DEG C of granulating after mixing;
3rd step, corn, dregs of beans, fish meal are taken out according to above-mentioned weight and mix rear pulverizing, mixed by the raw material crushed, incorporation time is 4 ~ 5 minutes, makes diameter 1 ~ 3mm particle, then vacuum drying at 45 ~ 55 DEG C by granulator;
4th step, the particle that the particle made by second step and the 3rd step are made mixes, and incorporation time is 4 ~ 5 minutes, obtains particulate material finished product.
8. the preparation method of feed as claimed in claim 7, it is characterized in that: the described first step is specially further to be pulverized respectively by each bulk drug component, send into stirrer for mixing by weight even, every 100g mixture, add the water of 500g ~ 600g, boil 3 ~ 4 hours, filter, obtain the first filtrate, the filter residue that 100g mixture obtains adds the water of 200g ~ 300g again, again boils 1 ~ 2 hour, filters, obtain the second filtrate, by the first filtrate and the mixing of the second filtrate, concentrated removing aqueous solvent, pulverizes, drying, obtains dry powder.
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