CN103520605B - For treating the feedstuff of eimeria tenella infection - Google Patents

Abstract

The invention provides a kind of feedstuff for treating eimeria tenella infection, its raw material includes Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and the above-mentioned Chinese medicine preparation for treating Eimeria tenella. The Chinese medicine preparation drug resistance that this feedstuff comprises is low, and drug residue is few, has no side effect, and has good therapeutic effect in treatment Eimeria tenella.

Description

For treating the feedstuff of eimeria tenella infection

Technical field

The present invention relates to technical field of Chinese medicine, particularly for the Chinese medicine preparation for the treatment of eimeria tenella infection.

Background technology

Eimeria tenella infection is a kind of serious parasitic disease parasitizing chicken intestinal caused by one or more Eimeria coccidiosiss, this disease M & M is all high, sickness rate is high to 50%～70%, mortality rate is 20%～30%, up to 80% time serious, bring huge economic loss to poultry husbandry in world wide. Chicken coccidiosis is serious to aviculture harm, is considered in poultry farming and expends the highest parasitic disease. This disease is generally mainly in spring or summer, but all can occur throughout the year in intensive chicken farm at present, causes huge loss to aviculture.

In current research, main still by following three kinds of approach control chicken coccidiosis: 1) strengthen feeding and management, environment purification; 2) application virulent strain, attenuated strain, multidrug resistant strain manufacture vaccine for treating chicken coccidiosis, but poor effect; 3) clinically medical treatment chicken coccidiosis be still main by way of, but the abuse of the life cycle complicated due to chicken coccidiosis and medicine particularly old medicine, result in serious drug resistance problems, meanwhile some chicken farm solves resistance problems by escalated dose and brings again food-safety problem. The occurring and how to prevent and treat primary disease and become two great difficult problems of current poultry husbandry of drug resistance, it is therefore necessary to put into substantial amounts of fund and time exploitation wide spectrum, efficiently, metabolism is fast, economical and the novel coccidiosis medicine of low-residual.

Apply now more medicine clinically and have the spirit of chlorine pyrrole alcohol, Sulfaquinoxaline, monensin, Robenidine, ball dysentery and penicillin etc.; but owing to raiser is inadequate to the consciousness of medicament protection; the abuse of medicine causes that the generation of drug resistance affects therapeutic effect; therefore develop a kind of new drug and compel as pressing as a fire singeing one's eyebrows, strengthen supporting family simultaneously and the reasonable employment of medicine is also very important.

Research shows that the traditional Chinese medicine of China has a large amount in variety and has Anti-human globulin test, and relative to chemical synthetic drug and antibiotic, it is low or have no side effect that Chinese medicine has toxic and side effects, noresidue and be not likely to produce the features such as drug resistance, current domestic preventing and treating coccidiosis is still based on Drug therapy, high dose continues to use Western medicine to be easily generated drug resistance, toxic and side effects, drug residue, to chicken body, meat, egg and sanitarian harm are increasing, and Chinese herbal medicine to have drug resistance low, drug residue is few, improve immunity of organisms and the advantage promoting the Western medicine such as animal body growth incomparable.

Summary of the invention

The technical problem to be solved is to provide a kind of for treating the Chinese medicine preparation of Eimeria tenella and comprising the feedstuff of this Chinese medicine preparation, its drug resistance is low, drug residue is few, has no side effect, and has effect significantly in treatment Eimeria tenella.

For solving above-mentioned technical problem, the invention provides a kind of Chinese medicine preparation for treating Eimeria tenella, its crude drug includes Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Fructus Cnidii, Herba Dendrobii, Radix Codonopsis, Rhizoma Polygonati, the Radix Paeoniae Alba, Radix Liriopes, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni and Dioscorea subcalva Prain et Burhll.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively as follows:

Flos Lonicerae 45g～55g, Fructus Kochiae 35g～45g, Bulbus Allii 35g～45g, Fructus Bruceae 25g～35g, Radix Pulsatillae 20g～30g, Fructus Jujubae 35g～45g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 30g～40g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 25g～35g, Radix Urenae Lobatae 35g～45g, Ramulus Persicae 40g～50g, Herba Hyperici 25g～35g, Radix Gentianae Macrophyllae 20g～30g, Radix Stemonae 25g～35g, Semen Pharbitidis 35g～45g, Cortex Ailanthi 25g～35g, Fructus Cnidii 45g～55g, Herba Dendrobii 35g～45g, Radix Codonopsis 75g～85g, Rhizoma Polygonati 55g～65g, Radix Paeoniae Alba 25g～35g, Radix Liriopes 25g～35g, Radix Et Caulis Acanthopanacis Senticosi 35g～45g, Fructus Corni 30g～40g and Dioscorea subcalva Prain et Burhll 35g～45g.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively as follows:

Flos Lonicerae 45g～50g, Fructus Kochiae 35g～40g, Bulbus Allii 35g～40g, Fructus Bruceae 25g～30g, Radix Pulsatillae 20g～25g, Fructus Jujubae 35g～40g, Rhizoma Imperatae 25g～30g, Folium Lantanae Camarae 30g～35g, Herba Taxilli 35g～40g, Caulis Sargentodoxae 25g～30g, Radix Urenae Lobatae 35g～40g, Ramulus Persicae 40g～45g, Herba Hyperici 25g～30g, Radix Gentianae Macrophyllae 20g～25g, Radix Stemonae 30g～35g, Semen Pharbitidis 40g～45g, Cortex Ailanthi 30g～35g, Fructus Cnidii 50g～55g, Herba Dendrobii 40g～45g, Radix Codonopsis 80g～85g, Rhizoma Polygonati 60g～65g, Radix Paeoniae Alba 30g～35g, Radix Liriopes 30g～35g, Radix Et Caulis Acanthopanacis Senticosi 40g～45g, Fructus Corni 35g～40g and Dioscorea subcalva Prain et Burhll 40g～45g.

Most preferably, in described Chinese medicine preparation, the weight of each crude drug is respectively as follows:

Flos Lonicerae 50g, Fructus Kochiae 40g, Bulbus Allii 40g, Fructus Bruceae 30g, Radix Pulsatillae 25g, Fructus Jujubae 40g, Rhizoma Imperatae 30g, Folium Lantanae Camarae 35g, Herba Taxilli 40g, Caulis Sargentodoxae 30g, Radix Urenae Lobatae 40g, Ramulus Persicae 45g, Herba Hyperici 30g, Radix Gentianae Macrophyllae 25g, Radix Stemonae 30g, Semen Pharbitidis 40g, Cortex Ailanthi 30g, Fructus Cnidii 50g, Herba Dendrobii 40g, Radix Codonopsis 80g, Rhizoma Polygonati 60g, Radix Paeoniae Alba 30g, Radix Liriopes 30g, Radix Et Caulis Acanthopanacis Senticosi 40g, Fructus Corni 35g and Dioscorea subcalva Prain et Burhll 40g.

The preparation method that present invention also offers above-mentioned Chinese medicine preparation, particularly as follows:

The first step, crude drug component each in described Chinese medicine preparation is mixed in proportion, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction to process 1～3 hour, decoction liquor is filtered, concentration, obtaining mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 DEG C);

Second step, the mastic of acquisition will add the ethanol that determining alcohol is 65% ~ 75% relative to first step mixture quality 3～5 times, it is stirred 20 minutes ~ 40 minutes, cold preservation 1 ~ 2 hour at 0～4 DEG C, filter, decompression recycling ethanol, it is thus achieved that dry cream, it is ground into the powder of 100 order ~ 200 orders, it is thus achieved that Chinese medicine preparation.

Present invention also offers a kind of feedstuff for treating Eimeria tenella, its raw material includes: Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and the above-mentioned Chinese medicine preparation for treating Eimeria tenella.

Wherein, in described feedstuff, each constituent content can be 9kg ~ 11kg Semen Tritici aestivi, 2kg ~ 3kg bean cake, the bone meal of 500g ~ 600g, 1kg ~ 2kg rapeseed meal, the dalcium biphosphate of 300g ~ 400g, the Chinese medicine preparation of the vitamin E of 100g ~ 200g, the vitamin K of 100g ~ 200g, the pantothenic acid of 150g ~ 250g, the lysine of 100g ~ 200g, the methionine of 100g ~ 200g, the threonine of 100g ~ 200g and 1kg ~ 2kg.

The preparation method that present invention also offers above-mentioned feedstuff, comprising:

The first step, crude drug component each in described Chinese medicine preparation is mixed in proportion, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction to process 1～3 hour, decoction liquor is filtered, concentration, obtaining mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 DEG C);

Second step, the mastic of acquisition will add the ethanol that determining alcohol is 65% ~ 75% relative to first step mixture quality 3～5 times, it is stirred 20 minutes ~ 40 minutes, cold preservation 1 ~ 2 hour at 0～4 DEG C, filter, decompression recycling ethanol, it is thus achieved that dry cream, it is ground into the powder of 100 order ~ 200 orders, it is thus achieved that Chinese medicine preparation;

3rd step, the Chinese medicine preparation mixing that Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and second step are obtained, pour in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 DEG C, open aerosol apparatus, stir 1 ~ 2 minute, be continuously heating to 90 DEG C and complete expanded;

4th step, adds the water relative to its quality 0.1 ~ 0.3 times by the product after expanded, puts in granulator and granulate, and granulator electric current is 175A;

5th step, dry after granulation, baking temperature is 105 DEG C, drying time 15 ~ 25min; Then cooling down, cooling blower electric current is 31A, packaging, it is thus achieved that described feedstuff.

Beneficial effects of the present invention:

Chinese medicine preparation for treating Eimeria tenella provided by the invention, its drug resistance is low, and drug residue is few, has no side effect, and has good therapeutic effect in treatment Eimeria tenella.

Detailed description of the invention

Chicken coccidiosis is mostly the evil class disease caused by (coccidiosis) of diseases caused by exogenous pathogenic factor worm, is mainly in the season of warm moist. Because of worm heresy impairment of blood and body fluid, and the tired spleen of retention of damp-heat in the interior, therefore to show as lack of appetite god idle the sick chicken initial stage, arranges thin excrement, wet in feces subsequently has mucus, has blood in stool, thirst and liking drink, and fear of cold flocks together, and cockscomb turns white, becomes thin, exhaustion is dead. Coccidiosis is dialectical for damp-heat syndrome by Chinese medicine, to effect a permanent cure, to take stopgap measures, strengthening vital QI to eliminate pathogenic factors for principle, therefore based on heat clearing and damp drying in treatment, think at the beginning of disease for " excess syndrome " by Chinese veterinarian's differential diagnosis in terms of eight principles, be " deficiency syndrome " afterwards, therefore control just many, heat clearing and damp drying eliminating evil based on parasite killing, after be then aided with QI invigorating qi-restoratives.

The invention provides a kind of Chinese medicine preparation for treating Eimeria tenella, its crude drug includes Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Fructus Cnidii, Herba Dendrobii, Radix Codonopsis, Rhizoma Polygonati, the Radix Paeoniae Alba, Radix Liriopes, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni and Dioscorea subcalva Prain et Burhll.

It is preferred that, described Chinese medicine preparation is only prepared from by above-mentioned raw materials medicine.

In described Chinese medicine preparation, the weight of each crude drug is respectively as follows:

Flos Lonicerae 45g～55g, Fructus Kochiae 35g～45g, Bulbus Allii 35g～45g, Fructus Bruceae 25g～35g, Radix Pulsatillae 20g～30g, Fructus Jujubae 35g～45g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 30g～40g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 25g～35g, Radix Urenae Lobatae 35g～45g, Ramulus Persicae 40g～50g, Herba Hyperici 25g～35g, Radix Gentianae Macrophyllae 20g～30g, Radix Stemonae 25g～35g, Semen Pharbitidis 35g～45g, Cortex Ailanthi 25g～35g, Fructus Cnidii 45g～55g, Herba Dendrobii 35g～45g, Radix Codonopsis 75g～85g, Rhizoma Polygonati 55g～65g, Radix Paeoniae Alba 25g～35g, Radix Liriopes 25g～35g, Radix Et Caulis Acanthopanacis Senticosi 35g～45g, Fructus Corni 30g～40g and Dioscorea subcalva Prain et Burhll 35g～45g.

Further, in described Chinese medicine preparation, the weight of each crude drug is respectively as follows:

Flos Lonicerae 45g～50g, Fructus Kochiae 35g～40g, Bulbus Allii 35g～40g, Fructus Bruceae 25g～30g, Radix Pulsatillae 20g～25g, Fructus Jujubae 35g～40g, Rhizoma Imperatae 25g～30g, Folium Lantanae Camarae 30g～35g, Herba Taxilli 35g～40g, Caulis Sargentodoxae 25g～30g, Radix Urenae Lobatae 35g～40g, Ramulus Persicae 40g～45g, Herba Hyperici 25g～30g, Radix Gentianae Macrophyllae 20g～25g, Radix Stemonae 30g～35g, Semen Pharbitidis 40g～45g, Cortex Ailanthi 30g～35g, Fructus Cnidii 50g～55g, Herba Dendrobii 40g～45g, Radix Codonopsis 80g～85g, Rhizoma Polygonati 60g～65g, Radix Paeoniae Alba 30g～35g, Radix Liriopes 30g～35g, Radix Et Caulis Acanthopanacis Senticosi 40g～45g, Fructus Corni 35g～40g and Dioscorea subcalva Prain et Burhll 40g～45g.

Further preferred, in described Chinese medicine preparation, the weight of each crude drug is respectively as follows:

Flos Lonicerae 50g, Fructus Kochiae 40g, Bulbus Allii 40g, Fructus Bruceae 30g, Radix Pulsatillae 25g, Fructus Jujubae 40g, Rhizoma Imperatae 30g, Folium Lantanae Camarae 35g, Herba Taxilli 40g, Caulis Sargentodoxae 30g, Radix Urenae Lobatae 40g, Ramulus Persicae 45g, Herba Hyperici 30g, Radix Gentianae Macrophyllae 25g, Radix Stemonae 30g, Semen Pharbitidis 40g, Cortex Ailanthi 30g, Fructus Cnidii 50g, Herba Dendrobii 40g, Radix Codonopsis 80g, Rhizoma Polygonati 60g, Radix Paeoniae Alba 30g, Radix Liriopes 30g, Radix Et Caulis Acanthopanacis Senticosi 40g, Fructus Corni 35g and Dioscorea subcalva Prain et Burhll 40g.

The pharmacology of described each crude drug is as follows:

Flos Lonicerae: sweet in the mouth, cold in nature, enters the heart, lung, stomach, large intestine channel, has the effect of heat-clearing and toxic substances removing, and holding concurrently can eliminating pathogenic heat from blood to cure dysentery. Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is relatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer is demonstrate,proved; The carbuncle sore that pyretic toxicity gathers is from the beginning of, heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, the phagocytic function of leukocyte can be promoted, multiple pyococcus and pathogenic entero becteria are had stronger bacteriostasis, including staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., Flos Lonicerae is all effective to the pyretic toxicity of QI and blood battalion point, and has broad-spectrum antibacterial action.

The Fructus Kochiae: latin name KochiaeFructus, cold in nature, acrid in the mouth, hardship, enter kidney, bladder warp, there is clearing away heat-damp and promoting diuresis, effect of dispelling wind for relieving itching, cure mainly the cards such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.

Bulbus Allii: warm in nature, acrid in the mouth is put down; Enter spleen, stomach, lung meridian, have warming middle-JIAO help digestion, the stagnant gas of row, warming the spleen and stomach, removing food stagnancy, removing toxic substances, parasite killing effect, cure mainly eating accumulation, coldness and pain in the epigastrium, edema distension, have loose bowels, dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea skin ulcer, snake bite and insect sting and the card such as ancylostome, pinworm.

Fructus Bruceae: latin name BruceaeFructus, bitter in the mouth, cold in nature, return large intestine channel, Liver Channel, there is heat-clearing and toxic substances removing, dysentery relieving, preventing the attack (or recurrence) of malaria, effect of corrosion wart, cure mainly dysentery, malaria; External treatment wart, clavus etc. are demonstrate,proved.

The Radix Pulsatillae: bitter in the mouth, cold in nature, enters stomach, large intestine channel, has heat-clearing and toxic substances removing, the effect of eliminating pathogenic heat from blood to cure dysentery, and being mainly used in gastrointestinal has damp and hot stagnant heating stomachache, dysentery pus and blood, and tenesmus etc. is demonstrate,proved; Hematodiarrhoea hematochezia better effects if to large intestine heat in blood, has inhibitory action to dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus.

Fructus Jujubae: latin name JujubaeFructus, sweet in the mouth, warm in nature, to return spleen, stomach warp, there is spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjust battalion to defend, solve effect of poison of drug, cure mainly insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation. Married woman's stolen goods are hot-tempered waits card.

Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, bladder warp, have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, being mainly used in lung stomach has the haematemesis of accumulated heat, hemoptysis;Damp invasion of lower energizer pents up the hematuria of bladder; Calentura excessive thirst taking fluids profusely; Gastropyretic vomiting; Jaundice due to damp-heat etc. are demonstrate,proved.

Folium Lantanae Camarae: bitter in the mouth, micro-sweet, cool in nature, there is heat clearing away, effect of hemostasis, cure mainly pulmonary tuberculosis hemoptysis, the cards such as stomachache is vomited and diarrhoea, eczema, pudendal pruritus.

Herba Taxilli: bitter in the mouth, sweet, property is put down, and enters liver, kidney channel, there is the effect of invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, the soreness of waist pain caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, the cards such as essence and blood void is lost, the frequent fetal movement of liability to abortion, waist abdomen pain.

Caulis Sargentodoxae: bitter in the mouth, property is put down, and returns liver, large intestine channel, has the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, and worm pain, injury from falling down etc. is demonstrate,proved.

Radix Urenae Lobatae: sweet in the mouth, light, property is put down, and enters the heart, lung meridian, has expelling wind and removing dampness, and effect of heat-clearing and toxic substances removing cures mainly cold, fever, rheumatic arthralgia, dysentery, edema, leucorrhea, spit blood, carbuncle, traumatic hemorrhage, venom, acute infantile convulsion, tetanus, asthma, stomachache puerperal exposure to wind etc. is demonstrate,proved.

Ramulus Persicae: latin name PersicaeRamulus, bitter in the mouth, property is put down, GUIXIN, Liver Channel, has promoting blood circulation to restore menstrual flow, and effect of removing toxic substances parasite killing, for cards such as trusted subordinate's twinge, rheumatic arthralgia, traumatic injury.

Herba Hyperici: bitter in the mouth, cold in nature, there is cooling blood for hemostasis, promoting blood flow to regulate menstruation, effect of eliminating fire and detoxication, cure mainly heat in blood spit blood, hematuria, have blood in stool, metrorrhagia, traumatic injury, traumatic hemorrhage, menoxenia, dysmenorrhea, agalactia, liver-fire headache, jaundice, scald, eczema, impetigo, venom etc. are demonstrate,proved.

Radix Gentianae Macrophyllae: latin name GentianaeMacrophyllaeRadix, acrid in the mouth, hardship, cold nature, return stomach warp, Liver Channel, gallbladder meridian, there is wind-damp dispelling, relaxing muscles and tendons network, effect of clearind deficient heat, cure mainly rheumatic arthralgia, muscle arteries and veins contracture, the cards such as joint is ached, afternoon fever, infantile malnutrition heating.

The Radix Stemonae: sweet in the mouth, hardship, slightly warm in nature, enters lung meridian, there is nourishing the lung to arrest cough, the effect of delousing parasite killing, Radix Stemonae temperature embellishes but not dry, and property is kept and do not walked, there is again the merit of using pungent drugs for dispersion and bitter drugs for purgation sending down the abnormal ascending QI, being mainly used in newly all for a long time coughing, be especially suitable to consumptive fever chronic cough person, the modern times are used for preventing and treating the cough of chronic bronchitis, the dry cough of pulmonary tuberculosis, pertussis etc. is demonstrate,proved.

Semen Pharbitidis: latin name SemenPharbitidis, cold in nature, bitter in the mouth, to return lung meridian, kidney channel, large intestine channel, there is removing fluid-retention by purgation, therapeutic method to keep the adverse QI flowing downwards expectorant, except effect of long-pending parasite killing, cure mainly edema ascites, beriberi generalized edema with distention of the chest and abdomen, phlegm retention is breathed with cough, complete works of constipated, dyspepsia malnutrition due to parasitic infestation, swollen ulcer drug.

Cortex Ailanthi: bitter in the mouth, puckery, cold in nature, enter large intestine, stomach, Liver Channel, there is heat clearing and damp drying, astringing intestine to stop diarrhea leukorrhagia stopping, hemostasis, the effect of parasite killing, for damp-heat dysentery, chronic diarrhea chronic dysentery, metrorrhagia, have blood in stool, hemorrhoid hematochezia, leukorrhagia, the card such as discharging fresh blood stool.

Fructus Cnidii: acrid in the mouth, hardship, warm in nature, enter kidney channel, there is the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the impotence in male, the woman's cold womb that cause for kidney yang deficiency are infertile, and cold-damp leukorrhagia or chills and pain of the waist and kness etc. are demonstrate,proved.

Herba Dendrobii: latin name DendrobiiCaulis, cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat, cures mainly cloudy impairment of body fluid and loses, xerostomia excessive thirst, the cards such as lack of appetite is retched, deficiency-heat after being ill, poor vision.

Radix Codonopsis: sweet in the mouth, property is put down, and returns lung, spleen channel, has QI invigorating strengthening the spleen, the symptoms such as effect of nourishing blood to promote the production of body fluid, cures mainly the fatigue and weakness of deficiency of both the splenic and pulmonary QI or QI and blood deficiency, breathes hard, cough spontaneous perspiration, Radix Codonopsis is longer than spleen reinforcing nourishing the stomach, adjust regulating the function of middle-JIAO, have the effect nourished blood concurrently, its property put down, spleen invigorating fortune and not dry; Flavour is cloudy and does not wet, it is possible to improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes the intestinal absorption to nutrient substance.

Rhizoma Polygonati: sweet in the mouth, the cards such as property is put down, and enters lung, spleen, kidney channel, has nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, and for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, early whitening of beard and hair.

The Radix Paeoniae Alba: latin name PaeoniaeRadixAlba, bitter in the mouth, acid, cool in nature, enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives effect of antiperspirant, cures mainly the chest and abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, it is with inferior card.

Radix Liriopes: sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, there is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, for dryness of the lung dry cough, cough due to consumptive disease, the cards such as Tianjin wound is thirsty, vexed insomnia, dryness of the intestine constipation.

Radix Et Caulis Acanthopanacis Senticosi: latin name AcanthopanacisSenticosiRadixetRhizomaseuCaulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, demonstrate,prove for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity is soft, be slow in action, body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched etc.

Fructus Corni: sour in the mouth, puckery, slightly warm in nature, return liver, kidney channel, there is liver and kidney tonifying, effect of essence astringing and desertion stemming. For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed. Interior-heat such as is quenched one's thirst at the card.

Dioscorea subcalva Prain et Burhll: acrid in the mouth, warm in nature, there is effect of invigorating the spleen and benefiting QI, invigorating the lung and the kidney, cure mainly insufficiency of the spleen lack of appetite, have loose bowels, emission due to deficiency of the kidney, to quench one's thirst, lung impairment and cough, traumatic injury etc. is demonstrate,proved.

Above-mentioned Chinese medicine preparation provided by the invention uses as feed additive.

The preparation method that present invention also offers above-mentioned Chinese medicine preparation, particularly as follows:

The first step, crude drug component each in described Chinese medicine preparation is mixed in proportion, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction to process 1～3 hour, decoction liquor is filtered, concentration, obtaining mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 DEG C);

Second step, the mastic of acquisition will add the ethanol that determining alcohol is 65% ~ 75% relative to first step mixture quality 3～5 times, it is stirred 20 minutes ~ 40 minutes, cold preservation 1 ~ 2 hour at 0～4 DEG C, filter, decompression recycling ethanol, it is thus achieved that dry cream, it is ground into the powder of 100 order ~ 200 orders, it is thus achieved that Chinese medicine preparation.

Present invention also offers a kind of feedstuff for treating Eimeria tenella, its raw material includes: Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and for treating the Chinese medicine preparation of Eimeria tenella.

In described feedstuff, each constituent content can be 9kg ~ 11kg Semen Tritici aestivi, 2kg ~ 3kg bean cake, the bone meal of 500g ~ 600g, 1kg ~ 2kg rapeseed meal, the dalcium biphosphate of 300g ~ 400g, the Chinese medicine preparation of the vitamin E of 100g ~ 200g, the vitamin K of 100g ~ 200g, the pantothenic acid of 150g ~ 250g, the lysine of 100g ~ 200g, the methionine of 100g ~ 200g, the threonine of 100g ~ 200g and 1kg ~ 2kg.

Further, in described feedstuff, each constituent content can be 10kg Semen Tritici aestivi, 2.5kg bean cake, the bone meal of 550g, 1.5kg rapeseed meal, the dalcium biphosphate of 350g, the Chinese medicine preparation of the vitamin E of 150g, the vitamin K of 150g, the pantothenic acid of 200g, the lysine of 150g, the methionine of 150g, the threonine of 150g and 1.5kg.

The preparation method that present invention also offers above-mentioned feedstuff, comprising:

The first step, crude drug component each in described Chinese medicine preparation is mixed in proportion, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction to process 1～3 hour, decoction liquor is filtered, concentration, obtaining mastic, the relative density of described mastic is 1.15 ~ 1.18 (65 DEG C);

Second step, the mastic of acquisition will add the ethanol that determining alcohol is 65% ~ 75% relative to first step mixture quality 3～5 times, it is stirred 20 minutes ~ 40 minutes, cold preservation 1 ~ 2 hour at 0～4 DEG C, filter, decompression recycling ethanol, it is thus achieved that dry cream, it is ground into the powder of 100 order ~ 200 orders, it is thus achieved that Chinese medicine preparation;

3rd step, the Chinese medicine preparation mixing that Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and second step are obtained, pour in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 DEG C, open aerosol apparatus, stir 1 ~ 2 minute, be continuously heating to 90 DEG C and complete expanded;

4th step, adds the water relative to its quality 0.1 ~ 0.3 times by the product after expanded, puts in granulator and granulate, and granulator electric current is 175A;

5th step, dry after granulation, baking temperature is 105 DEG C, drying time 15 ~ 25min; Then cooling down, cooling blower electric current is 31A, packaging, it is thus achieved that described feedstuff.

Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1 Chinese medicine preparation 1

By Flos Lonicerae 50g, Fructus Kochiae 40g, Bulbus Allii 40g, Fructus Bruceae 30g, Radix Pulsatillae 25g, Fructus Jujubae 40g, Rhizoma Imperatae 30g, Folium Lantanae Camarae 35g, Herba Taxilli 40g, Caulis Sargentodoxae 30g, Radix Urenae Lobatae 40g, Ramulus Persicae 45g, Herba Hyperici 30g, Radix Gentianae Macrophyllae 25g, Radix Stemonae 30g, Semen Pharbitidis 40g, Cortex Ailanthi 30g, Fructus Cnidii 50g, Herba Dendrobii 40g, Radix Codonopsis 80g, Rhizoma Polygonati 60g, Radix Paeoniae Alba 30g, Radix Liriopes 30g, Radix Et Caulis Acanthopanacis Senticosi 40g, Fructus Corni 35g and Dioscorea subcalva Prain et Burhll 40g mixing, obtain mixture, add the water of 3kg, carry out decoction to process 3 hours, decoction liquor is filtered, concentration, obtain mastic, described mastic is 1.18 the relative density of 65 DEG C, the mastic of acquisition will add the ethanol that determining alcohol is 75% of 4kg, it is stirred 40 minutes, cold preservation 2 hours at 0 DEG C, filter, decompression recycling ethanol, obtain and get dry extract, it is ground into the powder of 200 orders, obtain Chinese medicine preparation 1.

Embodiment 2 Chinese medicine preparation 2

By Flos Lonicerae 45g, Fructus Kochiae 35g, Bulbus Allii 35g, Fructus Bruceae 25g, Radix Pulsatillae 20g, Fructus Jujubae 35g, Rhizoma Imperatae 25g, Folium Lantanae Camarae 30g, Herba Taxilli 35g, Caulis Sargentodoxae 25g, Radix Urenae Lobatae 35g, Ramulus Persicae 40g, Herba Hyperici 25g, Radix Gentianae Macrophyllae 20g, Radix Stemonae 30g, Semen Pharbitidis 40g, Cortex Ailanthi 30g, Fructus Cnidii 50g, Herba Dendrobii 40g, Radix Codonopsis 80g, Rhizoma Polygonati 60g, Radix Paeoniae Alba 30g, Radix Liriopes 30g, Radix Et Caulis Acanthopanacis Senticosi 40g, Fructus Corni 35g and Dioscorea subcalva Prain et Burhll 40g mixing, obtain mixture, add the water of 3kg, carry out decoction to process 3 hours, decoction liquor is filtered, concentration, obtain mastic, described mastic is 1.18 the relative density of 65 DEG C, the mastic of acquisition will add the ethanol that determining alcohol is 75% of 4kg, it is stirred 40 minutes, cold preservation 2 hours at 0 DEG C, filter, decompression recycling ethanol, obtain and get dry extract, it is ground into the powder of 200 orders, obtain Chinese medicine preparation 2.

Embodiment 3 Chinese medicine preparation 3

By Flos Lonicerae 50g, Fructus Kochiae 40g, Bulbus Allii 40g, Fructus Bruceae 30g, Radix Pulsatillae 25g, Fructus Jujubae 40g, Rhizoma Imperatae 30g, Folium Lantanae Camarae 35g, Herba Taxilli 40g, Caulis Sargentodoxae 30g, Radix Urenae Lobatae 40g, Ramulus Persicae 45g, Herba Hyperici 30g, Radix Gentianae Macrophyllae 25g, Radix Stemonae 35g, Semen Pharbitidis 45g, Cortex Ailanthi 35g, Fructus Cnidii 55g, Herba Dendrobii 45g, Radix Codonopsis 85g, Rhizoma Polygonati 65g, Radix Paeoniae Alba 35g, Radix Liriopes 35g, Radix Et Caulis Acanthopanacis Senticosi 45g, Fructus Corni 40g and Dioscorea subcalva Prain et Burhll 45g mixing, obtain mixture, add the water of 2.7kg, carry out decoction to process 3 hours, decoction liquor is filtered, concentration, obtain mastic, described mastic is 1.18 the relative density of 65 DEG C, the mastic of acquisition will add the ethanol that determining alcohol is 75% of 3.5kg, it is stirred 40 minutes, cold preservation 2 hours at 0 DEG C, filter, decompression recycling ethanol, obtain and get dry extract, it is ground into the powder of 200 orders, obtain Chinese medicine preparation 3.

Embodiment 4 feedstuff

By 10kg Semen Tritici aestivi, 2.5kg bean cake, the bone meal of 550g, 1.5kg rapeseed meal, the dalcium biphosphate of 350g, Chinese medicine preparation mixing prepared by the vitamin E of 150g, the vitamin K of 150g, the pantothenic acid of 200g, the lysine of 150g, the methionine of 150g, the threonine of 150g and the embodiment 1 of 1.5kg, pouring in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 DEG C, opens aerosol apparatus, stir 1 ~ 2 minute, be continuously heating to 90 DEG C and complete expanded; Product after expanded being added the water relative to its quality 0.2 times, puts in granulator and granulate, granulator electric current is 175A, and dry after granulation, baking temperature is 105 DEG C, drying time 25min; Then cooling down, cooling blower electric current is 31A, packaging, it is thus achieved that described feedstuff.

Embodiment 5 therapeutic test

Coccidian oocyst

Eimeria maxima egg capsule is provided by Xibei Univ. of Agricultural & Forest Science & Technology veterinary parasite laboratory. Artificial challenge's non-ball worm chicken subculture 1 time before test, it is thus achieved that test egg capsule, 29 DEG C be cultured to Sporulated after, 4 DEG C of Refrigerator stores are standby.

Feeding feedstuff

The feedstuff of the feeding embodiment of the present invention 4 preparation

The packet of experimental animal and process

11 Day-old Broiler Chickens 550 that will purchase, is grouped after raising 3d with the feedstuff adaptability without anticoccidial drug. Packet started to weigh every plumage chicken body weight the same day, and selective body is great little close strong young 500, is randomly divided into 3 groups, i.e. blank group, positive controls and Chinese medicine preparation group, and often group chicken number is in Table 1. Packet terminates namely to carry out artificial challenge and therapeutic test.

Except blank group, every test chicken inoculation Sporulated Oocysts of E. maxima 1.0 × 10 during other 2 groups of 15 ages in days⁵Individual/only.

Infect the same day of coccidian oocyst, immediately each group of chicken is carried out according to above-mentioned packet situation the treatment of medicine and control drug. Except blank group and positive controls, Chinese medicine preparation group is the feedstuff of the feeding embodiment of the present invention 4 preparation, is used in conjunction 5d, blank group and positive controls feeding common wheat feedstuff. After infection every day checkout facility chicken spirit, the promoting the circulation of blood of going forward side by side of appetite, feces just score, after administration the 8th day, start to weigh, calculate survival rate, the rate of body weight gain of each group; And chicken all slaughtered cut open inspection, observe and carry out caecum lesion and score. Hemafecia is scored; Calculate caecum egg sac number, egg capsule than number, egg capsule value and anticoccidial index (ACI).

Evaluating drug effect index

Clinicing symptom observation

After inoculation coccidiosis, every day observes and records the incidence of each group of chicken, clinical symptoms. After infection the 4th, 5,6,7 day every day check feces, record hemafecia situation, carry out egg capsule counting, and dead chicken is cutd open inspection in time, find out the cause of death.

Chinese Herbs deliberated index and standard

Survival rate: survival rate (%)=survival chicken number/(test chicken sum-Yin Fei coccidium infection factor and die unexpectedly chicken number) × 100%.

Body weight increase rate: body weight increase rate (%)=administration group or infect and be not administered the rate of body weight gain/infection of group and be not administered rate of body weight gain × 100% of group.

Lesion score and pathological changes value

The order of severity according to cuing open inspection rear intestinal pathological changes is scored. 0 point: without naked eyes pathological changes; 1 point: intestinal wall has and is seldom dispersed in petechial hemorrhage, and intestinal wall does not thicken, and content is normal; 2 points: intestinal contents has a small amount of blood, and intestinal wall thickens, it is seen that most stigmas; 3 points: enteral has volume blood or intestinal core (blood clot or the caseous Fructus Musae block of canescence), intestinal wall is plump and significantly deforms and atrophy;4 points: the notable atrophy of intestinal, intestinal wall is extremely plump, and enteral contains blood clot or intestinal core, and when judging, the pathological changes of both sides caecum is inconsistent sometimes, then should be as the criterion judgement with pathological changes side heavily.

The group average lesion of pathological changes value=often scores × 10.

Egg capsule value

Convert according to gram feces egg capsule value (Oocystspergramfeces, an OPG) method.

When OPG value is 0.00～0.10, egg capsule value is 0; When OPG value is 0.11～1.00, egg capsule value is 1; When OPG value is 1.10～1.90, egg capsule value is 10; When OPG value is 2.00～5.90, egg capsule value is 20; When OPG value is 6.00～10.90, egg capsule value is 30; When OPG value >=11.0, egg capsule value is 40.

Anticoccidial index (AnticoccidialIndex, ACI)

Criterion calculation anticoccidial index with Merck company. Anticoccidial index (ACI)=(body weight increase rate+survival rate)-(pathological changes value+egg capsule value+hemafecia is scored).

Drug effect criterion is: when ACI is less than 120, it is determined that for weak curative effect; When ACI is 120～160, it is determined that medium for curative effect; When ACI is 160～180, it is determined that good for curative effect; When ACI is more than 180, it is determined that outstanding for curative effect.

Feces is scored

The feces started for 4th day after observing inoculation, the method with reference to Morehouse is scored, and namely the 4th day after artificial challenge starts to observe blood stool situation, by the most serious once the scoring of hemafecia, and calculates group mean. Feces normally remembers 0 point; This day every chicken on average occurs that how much piling hemafecia just remembers how many points respectively.

Pathologic changes

Attack after worm the 8th day, cut open and kill total Test chicken, it is cutd open inspection, take duodenum respectively, small intestinal leading portion, small intestinal back segment, caecum carry out observation and the lesion score of pathological change.

Pathologic examination

Making (H.E dyeing) flow process of histopathologic slide: draw materials 2 fix 2 flushing 2 gradient alcohol dehydration (70% ethanol-80% ethanol-90% ethanol-95% ethanol-100% ethanol I-100% ethanol II)-dimethylbenzene transparent-waxdip-embedding-paster-dyeing (dewaxing-dye nucleus-dye Cytoplasm-dehydration)-sealing. Light Microscopic observation also records Histopathologic changes.

Result

Clinical symptoms

3d after test chicken inoculation coccidiosis, it is depressed that chicken shows spirit, and feather pine disorderly, fear of cold, flocks together, diet be intended to decline even useless absolutely, then there is dysentery, hemafecia. Dead 52 of positive controls, the chicken that dies of illness cut open inspection see the obvious enlargement of caecum, hemorrhage or have blood clot. After test group medication, clinical symptoms alleviates gradually. After infection the 4th day, start to record test index; Within 8th day, weighing, catch and kill, observe caecum lesion and score, take cecal content to measure egg capsule value simultaneously, result is in Table 1.

Pathological observation

Observing pathological change result visible, there is not any pathological changes in negative control group, and positive controls pathological changes is the most serious, and Chinese medicine preparation group has pathological changes to occur.

Whole body each histopathology histological change situation is as follows:

Small intestinal: positive controls lamina propria telangiectasis is congested; Chinese medicine preparation group lamina propria, Submucosa capillary injection, expansion disappear.

Fabricius bursa: the concentration of positive controls fabricius bursa lamina propria lymphocyte nuclear, fragmentation; Chinese medicine preparation group fabricius bursa lamina propria lymphocyte nuclear concentration phenomena disappears.

Lungs: positive controls alveolar wall telangiectasis, are full of erythrocyte; Interstitial vasodilation. Chinese medicine preparation group alveolar wall telangiectasis disappears.

Liver: positive controls central vein, sinus hepaticus gap are expanded, is full of erythrocyte;Swelling of liver cell, muddiness. The expansion of Chinese medicine preparation group central vein, sinus hepaticus gap disappears.

Heart: positive controls cardiac muscle fiber swelling, has a large amount of subparticle in endochylema; Chinese medicine preparation group pathological changes is inconspicuous.

Brain: positive controls interstitial venule vasodilation is congested; Treatment by Chinese herbs group is without congested, bleeding, without significant change.

Kidney: positive controls renal cells swelling, endochylema is muddy, occurs a large amount of fine grained in endochylema. Part renal tubules tube chamber visible urinary cast is interstitial vasodilation, hyperemia, hemorrhage. Chinese medicine preparation group is without significant change.

Result is in Table 1.

Table 1 Chinese medicine preparation anticoccidial effect

Note: ACI represents that more than 180 anticoccidial effect is fine, represents that more than 160 anticoccidial effect is better, indicates without anticoccidial effect less than 160.

All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement and/or the new method that limit other forms. Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status. But, all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above. But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims (6)

1. one kind for treating the feedstuff of eimeria tenella infection, it is characterised in that: raw material includes Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and for treating the Chinese medicine preparation of eimeria tenella infection;

The crude drug of described Chinese medicine preparation is made up of Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Fructus Cnidii, Herba Dendrobii, Radix Codonopsis, Rhizoma Polygonati, the Radix Paeoniae Alba, Radix Liriopes, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni and Dioscorea subcalva Prain et Burhll;

The weight respectively Flos Lonicerae 45g～55g of each crude drug of described Chinese medicine preparation, Fructus Kochiae 35g～45g, Bulbus Allii 35g～45g, Fructus Bruceae 25g～35g, Radix Pulsatillae 20g～30g, Fructus Jujubae 35g～45g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 30g～40g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 25g～35g, Radix Urenae Lobatae 35g～45g, Ramulus Persicae 40g～50g, Herba Hyperici 25g～35g, Radix Gentianae Macrophyllae 20g～30g, Radix Stemonae 25g～35g, Semen Pharbitidis 35g～45g, Cortex Ailanthi 25g～35g, Fructus Cnidii 45g～55g, Herba Dendrobii 35g～45g, Radix Codonopsis 75g～85g, Rhizoma Polygonati 55g～65g, Radix Paeoniae Alba 25g～35g, Radix Liriopes 25g～35g, Radix Et Caulis Acanthopanacis Senticosi 35g～45g, Fructus Corni 30g～40g and Dioscorea subcalva Prain et Burhll 35g～45g.

2. feedstuff as claimed in claim 1, it is characterized in that: each raw material components is 9kg ~ 11kg Semen Tritici aestivi, 2kg ~ 3kg bean cake, the bone meal of 500g ~ 600g, 1kg ~ 2kg rapeseed meal, the dalcium biphosphate of 300g ~ 400g, the Chinese medicine preparation of the vitamin E of 100g ~ 200g, the vitamin K of 100g ~ 200g, the pantothenic acid of 150g ~ 250g, the lysine of 100g ~ 200g, the methionine of 100g ~ 200g, the threonine of 100g ~ 200g and 1kg ~ 2kg.

3. the preparation method of feedstuff described in claim 1 or 2, it is characterised in that including:

The first step, crude drug component each in described Chinese medicine preparation is mixed in proportion, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction to process 1～3 hour, decoction liquor is filtered, concentration, obtaining mastic, relative density during described mastic 65 DEG C is 1.15 ~ 1.18;

Second step, the mastic of acquisition will add the ethanol that determining alcohol is 65% ~ 75% relative to first step mixture quality 3～5 times, it is stirred 20 minutes ~ 40 minutes, cold preservation 1 ~ 2 hour at 0～4 DEG C, filter, decompression recycling ethanol, it is thus achieved that dry cream, it is ground into the powder of 100 order ~ 200 orders, it is thus achieved that Chinese medicine preparation;

3rd step, the Chinese medicine preparation mixing that Semen Tritici aestivi, bean cake, bone meal, rapeseed meal, dalcium biphosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine and second step are obtained, pour in spraying machine, in spraying machine, water temperature is modulated at 60 ~ 70 DEG C, open aerosol apparatus, stir 1 ~ 2 minute, be continuously heating to 90 DEG C and complete expanded;

4th step, adds the water relative to its quality 0.1 ~ 0.3 times by the product after expanded, puts in granulator and granulate, and granulator electric current is 175A;

5th step, dry after granulation, baking temperature is 105 DEG C, drying time 15 ~ 25min; Then cooling down, cooling blower electric current is 31A, packaging, it is thus achieved that described feedstuff.

4. the Chinese medicine preparation being used for treating eimeria tenella infection, it is characterised in that: crude drug is made up of Flos Lonicerae, the Fructus Kochiae, Bulbus Allii, Fructus Bruceae, the Radix Pulsatillae, Fructus Jujubae, Rhizoma Imperatae, Folium Lantanae Camarae, Herba Taxilli, Caulis Sargentodoxae, Radix Urenae Lobatae, Ramulus Persicae, Herba Hyperici, Radix Gentianae Macrophyllae, the Radix Stemonae, Semen Pharbitidis, Cortex Ailanthi, Fructus Cnidii, Herba Dendrobii, Radix Codonopsis, Rhizoma Polygonati, the Radix Paeoniae Alba, Radix Liriopes, Radix Et Caulis Acanthopanacis Senticosi, Fructus Corni and Dioscorea subcalva Prain et Burhll;

The weight of each crude drug is respectively as follows:

Flos Lonicerae 45g～55g, Fructus Kochiae 35g～45g, Bulbus Allii 35g～45g, Fructus Bruceae 25g～35g, Radix Pulsatillae 20g～30g, Fructus Jujubae 35g～45g, Rhizoma Imperatae 25g～35g, Folium Lantanae Camarae 30g～40g, Herba Taxilli 35g～45g, Caulis Sargentodoxae 25g～35g, Radix Urenae Lobatae 35g～45g, Ramulus Persicae 40g～50g, Herba Hyperici 25g～35g, Radix Gentianae Macrophyllae 20g～30g, Radix Stemonae 25g～35g, Semen Pharbitidis 35g～45g, Cortex Ailanthi 25g～35g, Fructus Cnidii 45g～55g, Herba Dendrobii 35g～45g, Radix Codonopsis 75g～85g, Rhizoma Polygonati 55g～65g, Radix Paeoniae Alba 25g～35g, Radix Liriopes 25g～35g, Radix Et Caulis Acanthopanacis Senticosi 35g～45g, Fructus Corni 30g～40g and Dioscorea subcalva Prain et Burhll 35g～45g.

5. Chinese medicine preparation as claimed in claim 4, it is characterised in that: the weight of each crude drug is respectively as follows:

Flos Lonicerae 45g～50g, Fructus Kochiae 35g～40g, Bulbus Allii 35g～40g, Fructus Bruceae 25g～30g, Radix Pulsatillae 20g～25g, Fructus Jujubae 35g～40g, Rhizoma Imperatae 25g～30g, Folium Lantanae Camarae 30g～35g, Herba Taxilli 35g～40g, Caulis Sargentodoxae 25g～30g, Radix Urenae Lobatae 35g～40g, Ramulus Persicae 40g～45g, Herba Hyperici 25g～30g, Radix Gentianae Macrophyllae 20g～25g, Radix Stemonae 30g～35g, Semen Pharbitidis 40g～45g, Cortex Ailanthi 30g～35g, Fructus Cnidii 50g～55g, Herba Dendrobii 40g～45g, Radix Codonopsis 80g～85g, Rhizoma Polygonati 60g～65g, Radix Paeoniae Alba 30g～35g, Radix Liriopes 30g～35g, Radix Et Caulis Acanthopanacis Senticosi 40g～45g, Fructus Corni 35g～40g and Dioscorea subcalva Prain et Burhll 40g～45g.

6. the preparation method of Chinese medicine preparation described in claim 4 or 5, it is characterised in that:

The first step, crude drug component each in described Chinese medicine preparation is mixed in proportion, obtain mixture, add the water relative to mixture quality 2 ~ 4 times, carry out decoction to process 1～3 hour, decoction liquor is filtered, concentration, obtaining mastic, relative density during described mastic 65 DEG C is 1.15 ~ 1.18;

Second step, the mastic of acquisition will add the ethanol that determining alcohol is 65% ~ 75% relative to first step mixture quality 3～5 times, it is stirred 20 minutes ~ 40 minutes, cold preservation 1 ~ 2 hour at 0～4 DEG C, filter, decompression recycling ethanol, it is thus achieved that dry cream, it is ground into the powder of 100 order ~ 200 orders, it is thus achieved that Chinese medicine preparation.