CN103202974B - Traditional Chinese medicine composition for treating coccidiosis in chicken - Google Patents
Traditional Chinese medicine composition for treating coccidiosis in chicken Download PDFInfo
- Publication number
- CN103202974B CN103202974B CN201310148132.4A CN201310148132A CN103202974B CN 103202974 B CN103202974 B CN 103202974B CN 201310148132 A CN201310148132 A CN 201310148132A CN 103202974 B CN103202974 B CN 103202974B
- Authority
- CN
- China
- Prior art keywords
- weight portions
- weight
- weight portion
- radix
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The invention provides a traditional Chinese medicine composition for treating coccidiosis in chicken. The traditional Chinese medicine composition comprises the following raw material medicines: radix sophorae flavescentis, pollen typhae, antifebrile dichroa, rheum officinale, rhizoma polygonati, acanthopanax, areca-nut, semen coicis, Chinese pulsatilla root, radix bupleuri, yellow hollyhock flower, rhizoma osmundae, camuning, lonicerae flos, saururus chinensis, golden larch bark, folium isatidis, dogwood, rainbow conk, codonopsis pilosula, pomegranate bark, azedarach and geranium wilfordii. Compared with western medicine therapy, the traditional Chinese medicine composition has the unique advantages of low drug tolerance, small drug residue, organism immunity improvement, animal organism growth prompting and the like.
Description
Technical field
The present invention relates to herbal medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis.
Background technology
Chicken coccidiosis is by sporozoa, Eimeriidae, it is caused with dysentery that one or several unicellular parasitic protozoas in Eimeria parasitize Intestinum Gallus domesticus tract epithelial cell, hemafecia, growth retardation, feed conversion rate reduces, death is the disease of feature, this disease M & M is all high, sickness rate is high to 50%～70%, mortality rate is 20%～30%, when serious, can reach 80%, with the easy infection of 15～4 age in days chickens and ill Serious Mortality rate, can reach 80%, annual approximately 2,000,000,000 pounds of the loss that the whole world causes because of chicken coccidiosis, bring huge economic loss to poultry husbandry in world wide.
The pathological changes of chicken coccidiosis and the cause of disease, find that pathological changes mainly occurs in small intestinal and caecum, its polypide parasitizes enteral, destroy intestinal mucosa epithelial cell, make a large amount of degeneration of mucosal epithelium cell, necrosis, disintegrate become noxious substance, be accumulated in intestinal tube and can not discharge rapidly, make body generation self poisoning and death.
Applying clinically now more is polyethers and chemical medicine, but prevent and treat this disease and need long-term continual medication, the long-term interpolation of chemicals has liver and intestinal toxicity, cause drug residue serious, very easily produce again drug resistance, have a strong impact on therapeutic effect, reduced the meat of chicken, the quality of egg product and safety, increasing to chicken body, meat, egg and sanitarian harm.Since the forties in last century, Levine found that sulfa drugs has anticoccidial effect, successively there have been 50 multi-medicaments to drop into clinical practices, for the development of poultry husbandry contributes.Yet along with the extensive use of medicine, coccidiosis Drug resistance problem is increasingly general and serious, the service life of medicine has been shortened in the generation of multiple drug resistance or cross-resistance greatly.Because coccidiosis very easily develops immunity to drugs to Western medicine, therefore, adopt treatment by Chinese herbs coccidiosis to become the emphasis of people's research.
Chinese herbal medicine has advantages of that drug resistance is low, drug residue is few, improve immunity of organisms and promote that the Western medicine such as animal body growth are incomparable, and utilizing Chinese herbal medicine to prevent and treat chicken coccidiosis is to solve a drug-fast good approach.Chinese medicine can directly kill polypide or suppress the non-specific and specific immunity of polypide enhancing body, alleviates clinical symptoms.Improve the especially lymphocytic quantity of T of peripheral blood lymphocyte simultaneously, also can obviously improve cellular immunization and the humoral immunity level of body.
The effect of Chinese herbal medicine anticoccidial, the growth that suppresses coccidiosis on the one hand, by regulating the resistance function of animal body on the other hand, breed and nonspecific resistance occurs to strengthen body disease-resistant power, arrive and eliminate pathogen and slow down it for the damage of cell, recover the object of the normal physiological function of body.Therefore, herbal control chicken coccidiosis has wide prospect.Develop efficient, super quality and competitive price, Chinese herbal and crude drugs preparations easy to use, will make huge contribution for the control of chicken coccidiosis and the development of poultry husbandry, the present invention is exactly on this basis, proposes a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis, and with respect to western medicine, it has advantages of, and drug resistance is low, drug residue is few, improve immunity of organisms and promote animal body growth etc. incomparable.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis, its crude drug comprises: Radix Sophorae Flavescentis, Pollen Typhae, Radix Dichroae, Radix Et Rhizoma Rhei, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Arecae, Semen Coicis, the Radix Pulsatillae, Radix Bupleuri, Flos abelmoschi manihot, Rhizoma Osmundae Japonicae, Folium Et Cacumen Murrayae, Flos Lonicerae, Rhizoma Saururi (Herba Saururi), Cortex Pseudolaricis, Folium Isatidis, Fructus Corni, Coriolous Dersicolor (Fr.) Quel, Radix Codonopsis, Pericarpium Granati, Cortex Meliae and Herba Erodii.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Sophorae Flavescentis 25 weight portion～35 weight portions, Pollen Typhae 30 weight portion～40 weight portions, Radix Dichroae 20 weight portion～30 weight portions, Radix Et Rhizoma Rhei 15 weight portion～25 weight portions, Rhizoma Polygonati 35 weight portion～45 weight portions, Radix Et Caulis Acanthopanacis Senticosi 50 weight portion～60 weight portions, Semen Arecae 25 weight portion～35 weight portions, Semen Coicis 30 weight portion～40 weight portions, the Radix Pulsatillae 25 weight portion～35 weight portions, Radix Bupleuri 20 weight portion～30 weight portions, Flos abelmoschi manihot 35 weight portion～45 weight portions, Rhizoma Osmundae Japonicae 25 weight portion～35 weight portions, Folium Et Cacumen Murrayae 20 weight portion～30 weight portions, Flos Lonicerae 30 weight portion～40 weight portions, Rhizoma Saururi (Herba Saururi) 40 weight portion～50 weight portions, Cortex Pseudolaricis 25 weight portion～35 weight portions, Folium Isatidis 65 weight portion～75 weight portions, Fructus Corni 30 weight portion～40 weight portions, Coriolous Dersicolor (Fr.) Quel 20 weight portion～30 weight portions, Radix Codonopsis 45 weight portion～55 weight portions, Pericarpium Granati 30 weight portion～40 weight portions, Cortex Meliae 25 weight portion～35 weight portions and Herba Erodii 20 weight portion～30 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Sophorae Flavescentis 28 weight portion～32 weight portions, Pollen Typhae 33 weight portion～37 weight portions, Radix Dichroae 23 weight portion～27 weight portions, Radix Et Rhizoma Rhei 18 weight portion～22 weight portions, Rhizoma Polygonati 38 weight portion～42 weight portions, Radix Et Caulis Acanthopanacis Senticosi 53 weight portion～57 weight portions, Semen Arecae 28 weight portion～32 weight portions, Semen Coicis 33 weight portion～37 weight portions, the Radix Pulsatillae 28 weight portion～32 weight portions, Radix Bupleuri 23 weight portion～27 weight portions, Flos abelmoschi manihot 38 weight portion～42 weight portions, Rhizoma Osmundae Japonicae 28 weight portion～32 weight portions, Folium Et Cacumen Murrayae 23 weight portion～27 weight portions, Flos Lonicerae 33 weight portion～37 weight portions, Rhizoma Saururi (Herba Saururi) 43 weight portion～47 weight portions, Cortex Pseudolaricis 28 weight portion～32 weight portions, Folium Isatidis 68 weight portion～72 weight portions, Fructus Corni 33 weight portion～37 weight portions, Coriolous Dersicolor (Fr.) Quel 23 weight portion～27 weight portions, Radix Codonopsis 48 weight portion～52 weight portions, Pericarpium Granati 33 weight portion～37 weight portions, Cortex Meliae 28 weight portion～32 weight portions and Herba Erodii 23 weight portion～27 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Sophorae Flavescentis 30 weight portions, Pollen Typhae 35 weight portions, Radix Dichroae 25 weight portions, Radix Et Rhizoma Rhei 20 weight portions, Rhizoma Polygonati 40 weight portions, Radix Et Caulis Acanthopanacis Senticosi 55 weight portions, Semen Arecae 30 weight portions, Semen Coicis 35 weight portions, the Radix Pulsatillae 30 weight portions, Radix Bupleuri 25 weight portions, Flos abelmoschi manihot 40 weight portions, Rhizoma Osmundae Japonicae 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, Flos Lonicerae 35 weight portions, Rhizoma Saururi (Herba Saururi) 45 weight portions, Cortex Pseudolaricis 30 weight portions, Folium Isatidis 70 weight portions, Fructus Corni 35 weight portions, Coriolous Dersicolor (Fr.) Quel 25 weight portions, Radix Codonopsis 50 weight portions, Pericarpium Granati 35 weight portions, Cortex Meliae 30 weight portions and Herba Erodii 25 weight portions.
Wherein, described Chinese medicine composition is prepared into decoction liquor, injection and powder.
The present invention also provides a kind of feedstuff, and it comprises normal feedstuff composition and as the above-mentioned Chinese medicine composition of Chinese medicine composition feed additive.
With respect to the normal feedstuff composition of 100 weight portions, the weight portion of described Chinese medicine composition feed additive is 10 weight portion～20 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is decoction liquor, concrete steps are that each raw material medicaments in part by weight is mixed, add with respect to 5～7 times of water of mixture, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, filtering residue adds the water with respect to 3～5 times, mixture again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, concentrated remove portion water, obtain the Chinese medicine composition decoction liquor that crude drug concentration is 1g/ml～2g/ml.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is injection, concrete steps are: each raw material medicaments in part by weight is mixed, add with respect to 5～7 times of water of mixture, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, filtering residue adds the water with respect to 3～5 times, mixture again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, with the hydrochloric acid solution of 4mol/l～6mol/l, regulate pH value to 2.0, cold preservation 48h, place precipitation, filter, filtrate regulates pH value to 7.0 with 20% sodium hydroxide solution, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is powder, concrete steps are: each raw material medicaments in part by weight is mixed, add with respect to 5～7 times of water of mixture, with intense fire, be heated to fluidized state, with slow fire boiling 2～4 hours, decoction liquor was filtered subsequently, and filtering residue adds the water with respect to 3～5 times, mixture again, with intense fire, be heated to fluidized state, with slow fire boiling 2～4 hours, decoction liquor was filtered subsequently, and the filtrate of twice acquisition is merged, concentrating under reduced pressure is except desolventizing, obtain mastic, be ground into powder, dry.
Beneficial effect of the present invention:
The Chinese medicine composition that is used for the treatment of chicken coccidiosis provided by the invention, with respect to western medicine, it has advantages of, and drug resistance is low, drug residue is few, improve immunity of organisms and promote animal body growth etc. incomparable.
The specific embodiment
According to the theory of Chinese veterinarian's determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, analyze the pathological changes cause of disease of chicken coccidiosis, mainly at small intestinal and caecum, the parasitic enteral of its polypide, destroy intestinal mucosa epithelial cell, make a large amount of degeneration necrosis of mucosal epithelium cell, disintegrate become noxious substance, be accumulated in intestinal tube and can not discharge rapidly and make body generation self poisoning and death.
Chicken coccidiosis is to invade body to the damp and hot endogenous cause of ill of body because worm is evil, the pyretic toxicity companion's blood of burning, and the absurd row of forcing blood, the strong fortune of taste is not normal, lassitude, rush down lower due to, thereby performance lack of appetite god is idle, passage of loose stools and just in band blood, finally developing into shaves dies of exhaustion.
Chinese medicine is by suppressing the maturation of unsporulated oocysts, kill Sporulated Oocysts, improve especially T lymphocyte quantity of peripheral blood lymphocyte, improve quantity and the activity of T, bone-marrow-derived lymphocyte in immune organ, the anticoccidial effect of Chinese herbal medicine is the growth that suppresses coccidiosis on the one hand, is by regulating the immunologic function of animal body on the other hand, produces nonspecific immunity with enhancing body premunition, reach and eliminate pathogen and alleviate it to histiocytic damage, recover the normal physiological merit of body
Accordingly, the present invention take heat clearing and damp drying, parasite killing dysentery relieving, protect the liver hemostasis be Therapeutic Principle, a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis is provided, and its crude drug comprises: Radix Sophorae Flavescentis, Pollen Typhae, Radix Dichroae, Radix Et Rhizoma Rhei, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Arecae, Semen Coicis, the Radix Pulsatillae, Radix Bupleuri, Flos abelmoschi manihot, Rhizoma Osmundae Japonicae, Folium Et Cacumen Murrayae, Flos Lonicerae, Rhizoma Saururi (Herba Saururi), Cortex Pseudolaricis, Folium Isatidis, Fructus Corni, Coriolous Dersicolor (Fr.) Quel, Radix Codonopsis, Pericarpium Granati, Cortex Meliae and Herba Erodii.Thereby scalable body's immunity, adapts to the mixed infection of prevention and treatment chicken coccidiosis and coccidiosis and antibacterial, produce omnibearing coordinative role and the integral body of body advantage factor is transferred to treating both the principal and secondary aspects of a disease.
In side, the anthelmintic of Radix Dichroae parasite killing, heat clearing and damp drying, it can reduce the metabolism disorder of the chicken in-vivo metal ion of medication generation, toleration when raising intestinal wall changes osmotic pressure, it is converted in vivo methionine and indirectly improves the immunity that infects coccidiosis chicken, the contained alkaloid of Radix Sophorae Flavescentis is the main component of anticoccidial, Radix Et Rhizoma Rhei has antiinflammatory and laxative action, can promote the discharge of polypide or egg capsule, Pollen Typhae blood circulation promoting and blood stasis dispelling improves Exploration of Red Cell Immuno-adhesive Function and the lymphocytic activity of T that infects coccidiosis chicken, Rhizoma Dryopteris Crassirhizomatis cooling blood for hemostasis, astringing intestine to stop diarrhea, antidiarrheal, can alleviate caused by coccidiosis hemorrhage, dysentery, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi boosting qi and nourishing yin, enriching kidney essence, can improve immunologic function, enhancing body resistance, Semen Arecae is killed and is suppressed coccidiosis and drive away exopathogen, Semen Coicis bowel relieving dampness, get rid of enterogenous endotoxin, the Radix Pulsatillae has astriction to intestinal mucosa, therefore there is antidiarrheal, the effect of hemostasis, Radix Bupleuri depressed liver-energy dispersing and QI regulating, elevate a turnable ladder yang-energy, cooling blood for hemostasis, removing toxic substances convergence, Flos abelmoschi manihot inducing diuresis for treating stranguria syndrome, promoting blood circulation and hemostasis, Rhizoma Osmundae Japonicae heat-clearing and toxic substances removing, hemostasis by removing blood stasis, parasite killing, Folium Et Cacumen Murrayae promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, pesticide and disinfectant, Rhizoma Saururi (Herba Saururi) inducing diuresis to remove edema, heat-clearing and toxic substances removing, Cortex Pseudolaricis killing parasites for relieving itching, Folium Isatidis heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, Fructus Corni liver and kidney tonifying, arresting collape syndrome by astringents, Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens, Coriolous Dersicolor (Fr.) Quel invigorating spleen to remove dampness, heat-clearing and toxic substances removing, Radix Codonopsis replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, Pericarpium Granati relieving diarrhea with astringents, hemostasis anthelmintic, Cortex Meliae pesticide and disinfectant, Herba Erodii wind-damp dispelling, the meridian dredging, antidiarrheal dysentery, all medicines are joined, get rid of evils, toxin expelling and Ying Wei, replenishing QI to invigorate the spleen, enhancing human body immunity power, thereby realize the treatment to chicken coccidiosis.
Further preferably, described Chinese medicine composition only consists of above-mentioned raw materials medicine.
In described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Sophorae Flavescentis 25 weight portion～35 weight portions, Pollen Typhae 30 weight portion～40 weight portions, Radix Dichroae 20 weight portion～30 weight portions, Radix Et Rhizoma Rhei 15 weight portion～25 weight portions, Rhizoma Polygonati 35 weight portion～45 weight portions, Radix Et Caulis Acanthopanacis Senticosi 50 weight portion～60 weight portions, Semen Arecae 25 weight portion～35 weight portions, Semen Coicis 30 weight portion～40 weight portions, the Radix Pulsatillae 25 weight portion～35 weight portions, Radix Bupleuri 20 weight portion～30 weight portions, Flos abelmoschi manihot 35 weight portion～45 weight portions, Rhizoma Osmundae Japonicae 25 weight portion～35 weight portions, Folium Et Cacumen Murrayae 20 weight portion～30 weight portions, Flos Lonicerae 30 weight portion～40 weight portions, Rhizoma Saururi (Herba Saururi) 40 weight portion～50 weight portions, Cortex Pseudolaricis 25 weight portion～35 weight portions, Folium Isatidis 65 weight portion～75 weight portions, Fructus Corni 30 weight portion～40 weight portions, Coriolous Dersicolor (Fr.) Quel 20 weight portion～30 weight portions, Radix Codonopsis 45 weight portion～55 weight portions, Pericarpium Granati 30 weight portion～40 weight portions, Cortex Meliae 25 weight portion～35 weight portions and Herba Erodii 20 weight portion～30 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is preferably respectively Radix Sophorae Flavescentis 28 weight portion～32 weight portions, Pollen Typhae 33 weight portion～37 weight portions, Radix Dichroae 23 weight portion～27 weight portions, Radix Et Rhizoma Rhei 18 weight portion～22 weight portions, Rhizoma Polygonati 38 weight portion～42 weight portions, Radix Et Caulis Acanthopanacis Senticosi 53 weight portion～57 weight portions, Semen Arecae 28 weight portion～32 weight portions, Semen Coicis 33 weight portion～37 weight portions, the Radix Pulsatillae 28 weight portion～32 weight portions, Radix Bupleuri 23 weight portion～27 weight portions, Flos abelmoschi manihot 38 weight portion～42 weight portions, Rhizoma Osmundae Japonicae 28 weight portion～32 weight portions, Folium Et Cacumen Murrayae 23 weight portion～27 weight portions, Flos Lonicerae 33 weight portion～37 weight portions, Rhizoma Saururi (Herba Saururi) 43 weight portion～47 weight portions, Cortex Pseudolaricis 28 weight portion～32 weight portions, Folium Isatidis 68 weight portion～72 weight portions, Fructus Corni 33 weight portion～37 weight portions, Coriolous Dersicolor (Fr.) Quel 23 weight portion～27 weight portions, Radix Codonopsis 48 weight portion～52 weight portions, Pericarpium Granati 33 weight portion～37 weight portions, Cortex Meliae 28 weight portion～32 weight portions and Herba Erodii 23 weight portion～27 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is most preferably respectively Radix Sophorae Flavescentis 30 weight portions, Pollen Typhae 35 weight portions, Radix Dichroae 25 weight portions, Radix Et Rhizoma Rhei 20 weight portions, Rhizoma Polygonati 40 weight portions, Radix Et Caulis Acanthopanacis Senticosi 55 weight portions, Semen Arecae 30 weight portions, Semen Coicis 35 weight portions, the Radix Pulsatillae 30 weight portions, Radix Bupleuri 25 weight portions, Flos abelmoschi manihot 40 weight portions, Rhizoma Osmundae Japonicae 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, Flos Lonicerae 35 weight portions, Rhizoma Saururi (Herba Saururi) 45 weight portions, Cortex Pseudolaricis 30 weight portions, Folium Isatidis 70 weight portions, Fructus Corni 35 weight portions, Coriolous Dersicolor (Fr.) Quel 25 weight portions, Radix Codonopsis 50 weight portions, Pericarpium Granati 35 weight portions, Cortex Meliae 30 weight portions and Herba Erodii 25 weight portions.
Chinese medicine composition provided by the invention can be prepared into decoction liquor, injection and powder.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is decoction liquor, concrete steps are that each raw material medicaments in part by weight is mixed, add with respect to 5～7 times of water of mixture, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, filtering residue adds the water with respect to 3～5 times, mixture again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, concentrated remove portion water, obtain the Chinese medicine composition decoction liquor that crude drug concentration is 1g/ml～2g/ml.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is injection, concrete steps are: each raw material medicaments in part by weight is mixed, add with respect to 5～7 times of water of mixture, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, filtering residue adds the water with respect to 3～5 times, mixture again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2～4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, with the hydrochloric acid solution of 4mol/l～6mol/l, regulate pH value to 2.0, cold preservation 48h, place precipitation, filter, filtrate regulates pH value to 7.0 with 20% sodium hydroxide solution, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
Injection provided by the invention can adopt the mode of intramuscular injection or intravenous drip to inject.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, when described Chinese medicine composition is powder, concrete steps are: each raw material medicaments in part by weight is mixed, add with respect to 5～7 times of water of mixture, with intense fire, be heated to fluidized state, with slow fire boiling 2～4 hours, decoction liquor was filtered subsequently, and filtering residue adds the water with respect to 3～5 times, mixture again, with intense fire, be heated to fluidized state, with slow fire boiling 2～4 hours, decoction liquor was filtered subsequently, and the filtrate of twice acquisition is merged, concentrating under reduced pressure is except desolventizing, obtain mastic, be ground into powder, dry.
The present invention also provides a kind of feedstuff, and it comprises normal feedstuff composition and Chinese medicine composition feed additive, and described Chinese medicine composition feed additive is above-mentioned Chinese medicine composition powder.
With respect to the normal feedstuff composition of 100 weight portions, the weight portion of described feed additive is 10 weight portion～20 weight portions, more preferably 18 weight portions.
Described normal feedstuff composition can be one or more mixing in Semen Tritici aestivi, Semen Maydis, Semen setariae, Testa Tritici.
In described feedstuff, sea can add other conventional feed additive, as vitamin, aminoacid and microorganism formulation, preferably add the microorganism formulation with treatment chicken coccidiosis, as the diclazuril microorganism pre-mixing agent of Sichuan Heng Tong animal pharmaceutical Co. Ltd production.
The present invention also provides the preparation method of above-mentioned feedstuff, and its step is specially:
The first step, prepares above-mentioned Chinese medicine composition powder according to the preparation method of above-mentioned Chinese medicine composition powder;
Second step, Chinese medicine composition powder prepared by the first step and normal feedstuff components in certain proportion are sent in blender and are stirred, and mix, and obtain feedstuff.
Radix Sophorae Flavescentis: latin name Sophorae Flavescentis Radix, bitter in the mouth, cold in nature, enter the heart, stomach, large intestine, urinary bladder channel, there is the effect of heat clearing and damp drying, wind dispelling insecticide, be mainly used in damp-heat dysentery, jaundice, stranguria, Radix Sophorae Flavescentis has obvious inhibitory action to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus.
Pollen Typhae: sweet in the mouth, property is flat, enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.
Radix Dichroae: latin name Dichroae Radix, bitter in the mouth, pungent, cold in nature, return lung, liver, heart channel, there is the effect of vomiting phlegm and saliva by emesis, cure mainly phlegm retention and stop gathering, the cards such as chest and diaphragm painful abdominal mass plug.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald, Radix Et Rhizoma Rhei hemostatic mechanism is that rhatannin can be restrained wound surface and stop blooding, can lower the permeability of blood capillary and improve its fragility, reduce the outflow of wound surface body fluid, having increases platelet, makes blood clotting time shorten, promotes the effect of blood coagulation, and Radix et Rhizoma Rhei (stir-fried with wine) is for Akamu pharyngeal swelling, gingivitis, Radix Et Rhizoma Rhei is got the property of its bitter cold sedimentation, and main purgation of spleen excess excess of the stomach fire and high Sheng be fire mutually, can make the fiery of inflammation following let out.
Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, the polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, the cards such as early whitening of beard and hair.
Radix Et Caulis Acanthopanacis Senticosi: latin name Acanthopanacis Senticosi Radix et Rhizomaseu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.
Semen Arecae: bitter in the mouth, pungent, warm in nature, return stomach, large intestine channel, there is parasite killing, removing food stagnancy, circulation of qi promoting, diuretic, the effect of preventing the attack (or recurrence) of malaria, cures mainly abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, the cards such as malaria.
Semen Coicis: sweet in the mouth, property are light, return spleen, stomach, lung meridian, have the effect of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, cure mainly dysuria, edema, beriberi, lung abscess, acute appendicitis, rheumatic arthralgia, the cards such as muscle arteries and veins contraction urgency and damp-warm diseases.
The Radix Pulsatillae: bitter in the mouth, cold in nature, enter stomach, large intestine channel, there is the effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, be mainly used in the intestines and stomach and have damp and hot stagnant heating stomachache, dysentery pus and blood, the treatment of the symptoms such as tenesmus, hematodiarrhoea hematochezia effect to large intestine heat in blood is better, and the Radix Pulsatillae all has certain inhibitory action to dysentery bacterium, Bacillus typhi, bacillus subtilis, escherichia coli, Staphyloccocus aureus.
Radix Bupleuri: bitter in the mouth, cold nature, returns Liver Channel, gallbladder meridian, have evacuate bring down a fever, the effect of yang invigorating soothing liver-QI, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the card such as uterus comes off, menoxenia.
Flos abelmoschi manihot: latin name Abelmoschus manihot (L.) Medic, sweet in the mouth, pungent, cool in nature, GUIXIN; Kidney; Urinary bladder channel, has inducing diuresis for treating stranguria syndrome; Invigorate blood circulation; Hemostasis; The effect of subduing swelling and detoxicating, main stranguria; Spit blood; Epistaxis; Metrorrhagia; Placenta retention; Carbuncle sore tumefacting virus; Burn due to hot liquid or fire.
Rhizoma Osmundae Japonicae: bitter in the mouth, cold nature, returns spleen, and stomach warp, has heat-clearing and toxic substances removing, hemostasis by removing blood stasis, the effect of parasite killing, for influenza; Epidemic encephalitis; Encephalitis b parotitis; Carbuncle pyogenic infections from tumour or sore; Measles; Chickenpox; Dysentery; Spit blood; Epistaxis; Have blood in stool; Metrorrhagia; Leukorrhagia; Pinworm; The cards such as cestode.
Folium Et Cacumen Murrayae: acrid in the mouth, micro-hardship, warm in nature, slightly poisonous, there is the effect of promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, for stomachache, rheumatic arthralgia, treating swelling and pain by traumatic injury, fracture, sore and toxic, venom, the cards such as eczema.
Flos Lonicerae: sweet in the mouth, cold in nature, return lung, the heart, stomach warp, there is the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens, cure mainly carbuncle furuncle, sore throat, red heat, toxic-heat and blood stasis, anemopyretic cold, the cards such as epidemic febrile disease.
Rhizoma Saururi (Herba Saururi): latin name Saururi Herba, sweet in the mouth, pungent, cold in nature, return lung, urinary bladder channel, there is clearing away heat and promoting diuresis; The effect of removing toxic substances and promoting subsidence of swelling, cures mainly pyretic stranguria; Stranguria with blood; Edema; Foot gas; Jaundice; Dysentery; Leukorrhagia; Carbuncle sore tumefacting virus; Eczema; The cards such as venom.
Cortex Pseudolaricis: latin name Pseudolaricis Cortex, acrid in the mouth, warm in nature, return lung, spleen channel, there is parasite killing, antipruritic effect, cures mainly scabies pruritus.
Folium Isatidis: bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, the effect of jaundice eliminating, the excess-heat can clearing heat in QI system dividing, can separate again the pyretic toxicity of blood system, the high febrile perspiration being mainly used in due to pestilence calentura goes out, excessive thirst taking fluids profusely; The speckle of sending out that fire-toxin is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash color is purple dark; Dampness-heat in the liver and gallbladder is accumulate the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The cards such as the pharyngalgia due to fire stagnation pyretic toxicity, aphtha of the mouth and tongue, hepatitis.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has liver and kidney tonifying, the effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.The interior-heat card such as quench one's thirst.
Coriolous Dersicolor (Fr.) Quel: sweet in the mouth, light, cold nature, returns liver; Spleen; Lung meridian, has invigorating spleen to remove dampness; Relieving cough and asthma; Heat-clearing and toxic substances removing; Antineoplastic effect, cures mainly chronic active hepatitis; Hepatitis interstitialis chronica; Chronic bronchitis; Infantile spasm bronchitis; Laryngopharynx swelling and pain; Kinds of tumors; Rheumatoid arthritis; The cards such as leukemia.
Radix Codonopsis: sweet in the mouth, property is flat, enters lung, spleen channel, has QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than spleen reinforcing nourishing the stomach, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes the absorption of intestinal to nutrient substance.
Pericarpium Granati: sour in the mouth, puckery, warm in nature, enter large intestine, kidney channel, there is relieving diarrhea with astringents, the effect of hemostasis parasite killing, for chronic diarrhea chronic dysentery, discharging fresh blood stool, bleeding not during menses, the cards such as abdominal pain due to worm stagnation.
Cortex Meliae: latin name Meliae Cortex, bitter in the mouth, cold in nature, return liver, spleen, stomach warp, there is parasite killing, treat tinea, for ascariasis, enterobiasis, the cards such as abdominal pain due to worm stagnation.
Herba Erodii: acrid in the mouth, hardship, property is flat, returns liver,kidney,spleen warp, has wind-damp dispelling, the meridian dredging, the effect of antidiarrheal profit, for rheumatic arthralgia, numbness contracture, the card such as muscles and bones is ached, dysentery.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 decoction liquor 1
By Radix Sophorae Flavescentis 30g, Pollen Typhae 35g, Radix Dichroae 25g, Radix Et Rhizoma Rhei 20g, Rhizoma Polygonati 40g, Radix Et Caulis Acanthopanacis Senticosi 55g, Semen Arecae 30g, Semen Coicis 35g, Radix Pulsatillae 30g, Radix Bupleuri 25g, Flos abelmoschi manihot 40g, Rhizoma Osmundae Japonicae 30g, Folium Et Cacumen Murrayae 25g, Flos Lonicerae 35g, Rhizoma Saururi (Herba Saururi) 45g, Cortex Pseudolaricis 30g, Folium Isatidis 70g, Fructus Corni 35g, Coriolous Dersicolor (Fr.) Quel 25g, Radix Codonopsis 50g, Pericarpium Granati 35g, Cortex Meliae 30g and Herba Erodii 25g mix, add 5kg water, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, filtering residue adds the water of 3.5kg again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, concentrated remove portion water, obtain the Chinese medicine composition decoction liquor 1 that crude drug concentration is 1g/ml.
Embodiment 2 decoction liquor 2
By Radix Sophorae Flavescentis 28g, Pollen Typhae 33g, Radix Dichroae 23g, Radix Et Rhizoma Rhei 18g, Rhizoma Polygonati 38g, Radix Et Caulis Acanthopanacis Senticosi 53g, Semen Arecae 28g, Semen Coicis 33g, Radix Pulsatillae 28g, Radix Bupleuri 23g, Flos abelmoschi manihot 38g, Rhizoma Osmundae Japonicae 28g, Folium Et Cacumen Murrayae 23g, Flos Lonicerae 33g, Rhizoma Saururi (Herba Saururi) 43g, Cortex Pseudolaricis 28g, Folium Isatidis 68g, Fructus Corni 33g, Coriolous Dersicolor (Fr.) Quel 23g, Radix Codonopsis 48g, Pericarpium Granati 33g, Cortex Meliae 28g and Herba Erodii 23g mix, add 5kg water, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, filtering residue adds the water of 3.5kg again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, concentrated remove portion water, obtain the Chinese medicine composition decoction liquor 2 that crude drug concentration is 1g/ml.
Embodiment 3 injection 1
By Radix Sophorae Flavescentis 30g, Pollen Typhae 35g, Radix Dichroae 25g, Radix Et Rhizoma Rhei 20g, Rhizoma Polygonati 40g, Radix Et Caulis Acanthopanacis Senticosi 55g, Semen Arecae 30g, Semen Coicis 35g, Radix Pulsatillae 30g, Radix Bupleuri 25g, Flos abelmoschi manihot 40g, Rhizoma Osmundae Japonicae 30g, Folium Et Cacumen Murrayae 25g, Flos Lonicerae 35g, Rhizoma Saururi (Herba Saururi) 45g, Cortex Pseudolaricis 30g, Folium Isatidis 70g, Fructus Corni 35g, Coriolous Dersicolor (Fr.) Quel 25g, Radix Codonopsis 50g, Pericarpium Granati 35g, Cortex Meliae 30g and Herba Erodii 25g mix, add 5kg water, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, filtering residue adds the water of 3.5kg again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, with the hydrochloric acid solution of 6mol/l, regulate pH value to 2.0, cold preservation 48h, place precipitation, filter, filtrate regulates pH value to 7.0 with 20% sodium hydroxide solution, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection 1.
Embodiment 4 injection 2
By Radix Sophorae Flavescentis 33g, Pollen Typhae 37g, Radix Dichroae 27g, Radix Et Rhizoma Rhei 22g, Rhizoma Polygonati 42g, Radix Et Caulis Acanthopanacis Senticosi 57g, Semen Arecae 32g, Semen Coicis 37g, Radix Pulsatillae 32g, Radix Bupleuri 27g, Flos abelmoschi manihot 42g, Rhizoma Osmundae Japonicae 32g, Folium Et Cacumen Murrayae 27g, Flos Lonicerae 37g, Rhizoma Saururi (Herba Saururi) 47g, Cortex Pseudolaricis 32g, Folium Isatidis 72g, Fructus Corni 37g, Coriolous Dersicolor (Fr.) Quel 27g, Radix Codonopsis 52g, Pericarpium Granati 37g, Cortex Meliae 32g and Herba Erodii 27g mix, add 5kg water, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, filtering residue adds the water of 3.5kg again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, with the hydrochloric acid solution of 6mol/l, regulate pH value to 2.0, cold preservation 48h, place precipitation, filter, filtrate regulates pH value to 7.0 with 20% sodium hydroxide solution, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection 1.
Embodiment 5 Chinese medicine composition powder 1
By Radix Sophorae Flavescentis 30g, Pollen Typhae 35g, Radix Dichroae 25g, Radix Et Rhizoma Rhei 20g, Rhizoma Polygonati 40g, Radix Et Caulis Acanthopanacis Senticosi 55g, Semen Arecae 30g, Semen Coicis 35g, Radix Pulsatillae 30g, Radix Bupleuri 25g, Flos abelmoschi manihot 40g, Rhizoma Osmundae Japonicae 30g, Folium Et Cacumen Murrayae 25g, Flos Lonicerae 35g, Rhizoma Saururi (Herba Saururi) 45g, Cortex Pseudolaricis 30g, Folium Isatidis 70g, Fructus Corni 35g, Coriolous Dersicolor (Fr.) Quel 25g, Radix Codonopsis 50g, Pericarpium Granati 35g, Cortex Meliae 30g and Herba Erodii 25g mix, add 5kg water, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, filtering residue adds the water of 3.5kg again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, concentrating under reduced pressure is except desolventizing, obtain mastic, be ground into powder, dry.
Embodiment 6 feedstuffs 1
Chinese medicine composition powder 1 prepared by 180g embodiment 5 and the Semen Tritici aestivi of 1kg are sent in blender and are stirred, and mix, and obtain feedstuff 1.
Embodiment 7 feedstuffs 2
The Chinese medicine composition powder 1 of 180g embodiment 5 preparations, the diclazuril microorganism pre-mixing agent of 50g Sichuan Heng Tong animal pharmaceutical Co. Ltd production and the Semen Tritici aestivi of 1kg are sent in blender and stirred, mix, obtain feedstuff 2.
Embodiment 8 animal datas
8.1 experimental animals and grouping
The white plumage broiler of honest AA that experimental animal adopts broiler breeding field, Jinan to provide, 22 ages in days, individual average body quality is 0.95kg.For examination chicken spirit, enlivening, search for food, drinking-water is normal, hat whisker is ruddy, feces is normal.For totally 400 of examination chickens, be divided at random 4 groups, 100 every group, be respectively Chinese medicine composition group, infect coccidiosis, gavaging subsequently the present invention is the Chinese medicine composition decoction liquor 1 of embodiment 1 preparation, morning, noon and afternoon each 1 time, each 50ml, medicine matched group, infect coccidiosis, take subsequently diclazuril, 200mg/kg, positive controls, only infects not administration of coccidiosis, negative control group, do not infect coccidiosis, not administration, each component group is raised.Grouping is raised and last week pouity dwelling place is cleaned, and with formalin and potassium permanganate fumigation (using formalin 28ml for every cubic metre, potassium permanganate 14g), pouity dwelling place is carried out to fumigation; Feedstuff adopts the honest young fowl premix material in Tianjin to feed, free choice feeding drinking-water.
8.2 EXPERIMENTAL DESIGN
During tested fowl raising to 20 age in days, by only claiming weight, and adjust that respectively to organize weight basic identical, infected group inoculation chicken coccidiosis Sporulated Oocysts.After 24h, medication group starts to feed the pastille feedstuff of regulation to off-test.Infect latter the 7th day, collect feces every day and claim quality, with Maxwell every gram of feces egg sac number of egg count method meter (OPG), and viewing test chicken situation and feces situation of change.Infect latter the 8th day, by whole tested chickens, claim weight, calculate and respectively organize rate of body weight gain and cut open and kill, carry out intestinal lesion score, complete data statistics.
8.3 medicines and source
Experimental agents: the decoction liquor 1 of the embodiment of the present invention 1 preparation, gavages each 50ml every day 3 times.
Control drug: according to generally acknowledging effectively, roughly the same comparable principle, select diclazuril medicine in contrast.Diclazuril is produced (product batch number is 100271140,50g/ bag) by Witter, Zhenjiang pharmaceutcal corporation, Ltd.This medicine is effective to various coccidiosiss, and coccidiosis is difficult for producing drug resistance to this medicine, and dosage is 200mg/kg, sneaks into administration in feedstuff.
8.4 mode of infection
8.4.1 egg capsule is originated: parvum oocyst adopts Single Oocyst of E. tenella (Eimeriatenella), by Chinese Academy of Agricultural Sciences's Shanghai verminosis of animal institute, is provided.
8.4.2 infect method: adopt artificial challenge's mode, through crop inoculating spores egg capsule 5 * 10
5individual.
8.5 observation index and method
8.5.1 clinical symptoms
Duration of test is observed and is recorded spirit, appetite and the feces of respectively organizing test chicken and discharges situation.
8.5.2 rate of body weight gain
Infect latter the 8th day, the single weight that only claims of total Test chicken, calculates and respectively organizes rate of body weight gain.Average body quality * 100% during rate of body weight gain=(after off-test average body during quality-on-test average body quality)/on-test; Rate of body weight gain * 100% of the rate of body weight gain/negative control group of the relative weight gain rate=drug test group or positive control drug group.
8.5.3 survival rate
Survival rate=survival chicken quantity/initial chicken quantity * 100%.
8.5.4 feces is scored
4-8 days after inoculation egg capsule, viewing test chicken situation and feces situation of change.According to following standard, score: normal 0 minute; A small amount of hemafecia 1 minute; Moderate hemafecia 2 minutes; Many hemafecias 3 minutes; The normal feces of nothing 4 minutes.The number of times meter of not noting down for 0 minute.Average feces scores=every group of chicken manure sum/record number of times of just scoring.
8.5.5 lesion score
All pathological changes person counts 3 minutes below, has wherein 2 persons to count 2 minutes, has wherein 1 person to count 1 minute, without pathological changes person, counts 0 minute.(1) the obvious enlargement of both sides caecum, serosal surface has a large amount of petechias, and enteral is full of pitchy and partly solidifies clot.(2) caecum intestinal wall thickening being etched, as be convalescent sick chicken, caecum atrophy, hardening, be full of caseous substance in enteric cavity, present typical intestinal core shape.(3) small intestinal intestinal wall thickens, and mucous membrane surface is wheat bran shape, and serous coat has the downright bad point of serious white as seen, has many little petechias on intestinal mucosa, and schizont breeding place has pale speckle.Average lesion score * 10 of pathological changes value=every group of chicken.
8.5.6 cecal content egg capsule situation
After infecting, chicken was all cutd open and killed in the 8th day, get cecal content, calculate OPG and be converted into egg capsule value, the ratio of metainfective the 8th day chicken OPG value is less than 1%, and egg capsule value is 0; 1%～2% time, egg capsule value is 5; 25%～50% time, egg capsule value is 10; 50%～75% time, egg capsule value is 20; 70%～100% time, egg capsule value is 40.
8.5.7 anticoccidial index (ACI)
Press the computing formula of Merck (Merck) company, ACI<120 is invalid, and in being by the time effectively, ACI=160～180 are good in ACI=120～160, and ACI > 180 is outstanding.
ACI=(the relative weight gain rate+survival rate)-(egg capsule value+pathological changes value).
8.6 results and analysis
8.6.1 different disposal chickling clinical manifestation
Drug test group is after infection coccidiosis 24h, and all chicken down in spirits, loose random, the loss of appetite or absolutely useless of feather, often peel off to stay and stand; Wing is sagging, be slow in action, growth promoter stagnation, anemia, cockscomb and mucosa pale, draw water sample stench bloody stool, anus around feather by feces, stained, like drinking-water; Later stage skeletonize.Negative control group chicken spirit, appetite, feces are all normal.Positive controls starts to discharge hemafecia in the 3rd day from infecting, and is continued until off-test, within the 7th day, is total to dead 19 respectively with after infecting the 4th day after infecting.There is a small amount of hemafecia for the 4th day after infection in drug test group, dead 1 of Chinese drug-treated group the 5th day, all stops hemafecia on the 7th day, and spirit is recovered substantially, and appetite is tending towards normally, dead 5 of medicine matched group the 5th day.
8.6.2 respectively form motility rate comparison, the results are shown in Table 1.
Table 1 respectively forms motility rate comparison
| Group | Initial chicken number/only | Death toll/only | Survival rate/% |
| Negative control group | 100 | 0 | 100% |
| Positive controls | 100 | 38 | 62% |
| Medicine matched group | 100 | 5 | 95% |
| Chinese drug-treated group | 100 | 1 | 99% |
As can be seen from Table 1, adopt Chinese medicine composition of the present invention can obviously improve the survival rate of the chicken that suffers from coccidiosis.
8.6.3 respectively organize rate of body weight gain comparison, the results are shown in Table 2.
Each test group of table 2 AA Broiler Chicken mass change
| Group | Initial average body | Off-test is average | Rate of body weight gain/% | The relative weight gain rate |
| ? | Heavy (kg/ only) | Body weight (kg/ only) | ? | /% |
| Negative control group | 0.94 | 1.70 | 80.8 | - |
| Positive controls | 0.95 | 1.48 | 55.7 | 68.9 |
| Medicine matched group | 0.95 | 1.55 | 63.1 | 78.0 |
| Chinese drug-treated group | 0.95 | 1.69 | 76.4 | 94.5 |
As can be seen from Table 2, take the body weight gain rate that Chinese medicine composition of the present invention can obviously improve broiler.
8.6.4 respectively organize feces situation
Each group is except negative control group, and chicken all occurs serious hemafecia at infection coccidiosis 4～5d.After 6d, going out hemafecia stops gradually.Feces is scored: negative control group is 0 minute, and positive controls, medicine matched group group are 4 minutes, and Chinese drug-treated group is 3 minutes.
8.6.5 egg capsule value
As can be seen from Table 3, each organize egg capsule value the highest be to infect not medication group, be 40, all the other respectively organize egg capsule value is 10, lower than infecting not medication group egg sac number.
8.6.6 pathological changes value
As can be seen from Table 3, infecting is 23.0 without pathological changes value, and medicine matched group is 22.3, and Chinese drug-treated group is 13.3.
8.6.7 anticoccidial index (ACI)
Table 3 can find out, Chinese drug-treated group ACI, higher than 160, is good lower than 180, ACI, belongs to medium anticoccidial effect; The ACI of medicine matched group, lower than 160, is poor higher than 120, ACI.
Table 3 is respectively organized anticoccidial index (ACI) relatively
| Group | Chicken quantity/only | Pathological changes value | Egg capsule value | ACI |
| Negative control group | 100 | 0.0 | 0 | - |
| Positive controls | 100 | 23.0 | 40 | - |
| Medicine matched group | 100 | 22.3 | 10 | 142.1 |
| Chinese drug-treated group | 100 | 13.3 | 10 | 171.2 |
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. a Chinese medicine composition that is used for the treatment of chicken coccidiosis, is characterized in that: the crude drug of described Chinese medicine composition only consists of Radix Sophorae Flavescentis, Pollen Typhae, Radix Dichroae, Radix Et Rhizoma Rhei, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Semen Arecae, Semen Coicis, the Radix Pulsatillae, Radix Bupleuri, Flos abelmoschi manihot, Rhizoma Osmundae Japonicae, Folium Et Cacumen Murrayae, Flos Lonicerae, Rhizoma Saururi (Herba Saururi), Cortex Pseudolaricis, Folium Isatidis, Fructus Corni, Coriolous Dersicolor (Fr.) Quel, Radix Codonopsis, Pericarpium Granati, Cortex Meliae and Herba Erodii;
In described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Sophorae Flavescentis 25 weight portion ~ 35 weight portions, Pollen Typhae 30 weight portion ~ 40 weight portions, Radix Dichroae 20 weight portion ~ 30 weight portions, Radix Et Rhizoma Rhei 15 weight portion ~ 25 weight portions, Rhizoma Polygonati 35 weight portion ~ 45 weight portions, Radix Et Caulis Acanthopanacis Senticosi 50 weight portion ~ 60 weight portions, Semen Arecae 25 weight portion ~ 35 weight portions, Semen Coicis 30 weight portion ~ 40 weight portions, the Radix Pulsatillae 25 weight portion ~ 35 weight portions, Radix Bupleuri 20 weight portion ~ 30 weight portions, Flos abelmoschi manihot 35 weight portion ~ 45 weight portions, Rhizoma Osmundae Japonicae 25 weight portion ~ 35 weight portions, Folium Et Cacumen Murrayae 20 weight portion ~ 30 weight portions, Flos Lonicerae 30 weight portion ~ 40 weight portions, Rhizoma Saururi (Herba Saururi) 40 weight portion ~ 50 weight portions, Cortex Pseudolaricis 25 weight portion ~ 35 weight portions, Folium Isatidis 65 weight portion ~ 75 weight portions, Fructus Corni 30 weight portion ~ 40 weight portions, Coriolous Dersicolor (Fr.) Quel 20 weight portion ~ 30 weight portions, Radix Codonopsis 45 weight portion ~ 55 weight portions, Pericarpium Granati 30 weight portion ~ 40 weight portions, Cortex Meliae 25 weight portion ~ 35 weight portions and Herba Erodii 20 weight portion ~ 30 weight portions.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Sophorae Flavescentis 28 weight portion ~ 32 weight portions, Pollen Typhae 33 weight portion ~ 37 weight portions, Radix Dichroae 23 weight portion ~ 27 weight portions, Radix Et Rhizoma Rhei 18 weight portion ~ 22 weight portions, Rhizoma Polygonati 38 weight portion ~ 42 weight portions, Radix Et Caulis Acanthopanacis Senticosi 53 weight portion ~ 57 weight portions, Semen Arecae 28 weight portion ~ 32 weight portions, Semen Coicis 33 weight portion ~ 37 weight portions, the Radix Pulsatillae 28 weight portion ~ 32 weight portions, Radix Bupleuri 23 weight portion ~ 27 weight portions, Flos abelmoschi manihot 38 weight portion ~ 42 weight portions, Rhizoma Osmundae Japonicae 28 weight portion ~ 32 weight portions, Folium Et Cacumen Murrayae 23 weight portion ~ 27 weight portions, Flos Lonicerae 33 weight portion ~ 37 weight portions, Rhizoma Saururi (Herba Saururi) 43 weight portion ~ 47 weight portions, Cortex Pseudolaricis 28 weight portion ~ 32 weight portions, Folium Isatidis 68 weight portion ~ 72 weight portions, Fructus Corni 33 weight portion ~ 37 weight portions, Coriolous Dersicolor (Fr.) Quel 23 weight portion ~ 27 weight portions, Radix Codonopsis 48 weight portion ~ 52 weight portions, Pericarpium Granati 33 weight portion ~ 37 weight portions, Cortex Meliae 28 weight portion ~ 32 weight portions and Herba Erodii 23 weight portion ~ 27 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Sophorae Flavescentis 30 weight portions, Pollen Typhae 35 weight portions, Radix Dichroae 25 weight portions, Radix Et Rhizoma Rhei 20 weight portions, Rhizoma Polygonati 40 weight portions, Radix Et Caulis Acanthopanacis Senticosi 55 weight portions, Semen Arecae 30 weight portions, Semen Coicis 35 weight portions, the Radix Pulsatillae 30 weight portions, Radix Bupleuri 25 weight portions, Flos abelmoschi manihot 40 weight portions, Rhizoma Osmundae Japonicae 30 weight portions, Folium Et Cacumen Murrayae 25 weight portions, Flos Lonicerae 35 weight portions, Rhizoma Saururi (Herba Saururi) 45 weight portions, Cortex Pseudolaricis 30 weight portions, Folium Isatidis 70 weight portions, Fructus Corni 35 weight portions, Coriolous Dersicolor (Fr.) Quel 25 weight portions, Radix Codonopsis 50 weight portions, Pericarpium Granati 35 weight portions, Cortex Meliae 30 weight portions and Herba Erodii 25 weight portions.
4. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that: described Chinese medicine composition is prepared into decoction liquor, injection and powder.
5. a feedstuff, is characterized in that: comprise normal feedstuff composition and as the Chinese medicine composition described in the claims 1 to 3 any one of Chinese medicine composition feed additive.
6. feedstuff as claimed in claim 5, is characterized in that: with respect to the normal feedstuff composition of 100 weight portions, the weight portion of described Chinese medicine composition feed additive is 10 weight portion ~ 20 weight portions.
7. the preparation method of Chinese medicine composition described in claim 1 or 2, it is characterized in that: when the dosage form of described Chinese medicine composition is decoction liquor, concrete steps are that each raw material medicaments in part by weight is mixed, add with respect to 5 ~ 7 times of water of mixture, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2 ~ 4 hours, decoction liquor is filtered, filtering residue adds the water with respect to 3 ~ 5 times, mixture again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2 ~ 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, concentrated remove portion water, obtain the Chinese medicine composition decoction liquor that crude drug concentration is 1g/ml ~ 2g/ml.
8. the preparation method of Chinese medicine composition described in claim 1 or 2, it is characterized in that: when described Chinese medicine composition is injection, concrete steps are: each raw material medicaments in part by weight is mixed, add with respect to 5 ~ 7 times of water of mixture, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2 ~ 4 hours, decoction liquor is filtered, filtering residue adds the water with respect to 3 ~ 5 times, mixture again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2 ~ 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, with the hydrochloric acid solution of 4mol/l～6mol/l, regulate pH value to 2.0, cold preservation 48h, place precipitation, filter, filtrate regulates pH value to 7.0 with 20% sodium hydroxide solution, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, inject water to 1000ml, canned, in 115 ℃ of sterilizings 30 minutes, cold preservation 48 hours, filter, subpackage, obtain injection.
9. the preparation method of Chinese medicine composition described in claim 1 or 2, it is characterized in that: when described Chinese medicine composition is powder, concrete steps are: each raw material medicaments in part by weight is mixed, add with respect to 5 ~ 7 times of water of mixture, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2 ~ 4 hours, decoction liquor is filtered, filtering residue adds the water with respect to 3 ~ 5 times, mixture again, with intense fire, be heated to fluidized state, subsequently with slow fire boiling 2 ~ 4 hours, decoction liquor is filtered, the filtrate of twice acquisition is merged, concentrating under reduced pressure is except desolventizing, obtain mastic, be ground into powder, dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310148132.4A CN103202974B (en) | 2013-04-25 | 2013-04-25 | Traditional Chinese medicine composition for treating coccidiosis in chicken |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310148132.4A CN103202974B (en) | 2013-04-25 | 2013-04-25 | Traditional Chinese medicine composition for treating coccidiosis in chicken |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103202974A CN103202974A (en) | 2013-07-17 |
| CN103202974B true CN103202974B (en) | 2014-11-12 |
Family
ID=48750528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310148132.4A Expired - Fee Related CN103202974B (en) | 2013-04-25 | 2013-04-25 | Traditional Chinese medicine composition for treating coccidiosis in chicken |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103202974B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721046A (en) * | 2013-10-24 | 2014-04-16 | 青岛华仁技术孵化器有限公司 | Drug for treating chicken Eimeria tenella |
| CN103992874B (en) * | 2014-05-20 | 2016-06-01 | 河南中烟工业有限责任公司 | Flower of Sunset Abelmoschus aqueous extract and the application in cigarette thereof |
| CN104027420B (en) * | 2014-07-01 | 2016-04-13 | 施瑞客（天津）生物技术有限公司 | A kind of fowl Chinese medicine composition preventing and treating coccidiosis and preparation method thereof |
| CN105250565A (en) * | 2015-10-26 | 2016-01-20 | 张庆霞 | Chinese and Western compound medicine composition, preparation method thereof and application thereof |
| CN105901398A (en) * | 2016-04-25 | 2016-08-31 | 大新县生产力促进中心 | Pure natural chicken feed additive and preparation method thereof |
| CN105935105A (en) * | 2016-04-25 | 2016-09-14 | 大新县生产力促进中心 | Pure traditional Chinese medicine chicken feed additive and preparation method thereof |
| CN105901400A (en) * | 2016-04-25 | 2016-08-31 | 大新县生产力促进中心 | Chicken feed additive and preparation method thereof |
| CN107232400A (en) * | 2017-07-27 | 2017-10-10 | 陈长辉 | A kind of egg feedstuff Chinese medicine additive |
| CN114073283A (en) * | 2020-08-12 | 2022-02-22 | 吉林大学 | Medical application of cornus walteri oil residue as feed additive in resisting coccidiosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167918A (en) * | 2007-10-25 | 2008-04-30 | 杨成全 | Traditional Chinese medicinal preparation for increasing immunity of pig or poultry |
-
2013
- 2013-04-25 CN CN201310148132.4A patent/CN103202974B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167918A (en) * | 2007-10-25 | 2008-04-30 | 杨成全 | Traditional Chinese medicinal preparation for increasing immunity of pig or poultry |
Non-Patent Citations (8)
| Title |
|---|
| 中草药防治鸡、兔球虫病的研究进展;卢福庄等;《浙江农业学报》;20071231;第19卷(第3期);253-257 * |
| 中草药防治鸡球虫病的研究进展;倪耀娣等;《中兽医学杂志》;20021231(第3期);42-43 * |
| 倪耀娣等.中草药防治鸡球虫病的研究进展.《中兽医学杂志》.2002,(第3期),42-43. * |
| 卢福庄等.中草药防治鸡、兔球虫病的研究进展.《浙江农业学报》.2007,第19卷(第3期),253-257. * |
| 张国红.按中草药对畜禽疾病病原体作用分类初探.《云南畜牧兽医》.1997,(第3期),34-35. * |
| 按中草药对畜禽疾病病原体作用分类初探;张国红;《云南畜牧兽医》;19971231(第3期);34-35 * |
| 秦枫等.防治球虫病的常用中草药研究进展.《中国医药导报》.2007,第4卷(第35期),19-20. * |
| 颜卉等.中草药添加剂在养鸡生产中的应用.《中国家禽》.2005,第27卷(第18期),47-49. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103202974A (en) | 2013-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103202974B (en) | Traditional Chinese medicine composition for treating coccidiosis in chicken | |
| CN103689296B (en) | Feed for ewe at later pregnancy and lactation period and preparation method thereof | |
| CN103750060B (en) | Feed for treating pig influenza and preparation method thereof | |
| CN103721103B (en) | Medicine being used for the treatment of pig erysipelas and preparation method thereof | |
| CN104258139A (en) | Pharmaceutical composition for preventing and treating chronic swine plague and preparation method of pharmaceutical composition | |
| CN105833185A (en) | Traditional Chinese medicine composition for preventing and treating colibacillosis of domestic rabbits | |
| CN103520605B (en) | For treating the feedstuff of eimeria tenella infection | |
| CN103494927B (en) | Traditional Chinese medicine composition for treating chicken respiratory disease and preparation method thereof | |
| CN102488847A (en) | Traditional Chinese medicine composition for treating chicken infectious bursal disease as well as preparation method and application thereof | |
| CN102698158B (en) | Traditional Chinese medicine for preventing and treating infectious bronchitis, preparation method thereof and feed | |
| CN103960542B (en) | A kind of feed for preventing and treating swine eperythrozoonosis and Chinese medicine composition | |
| CN103142907A (en) | Immunopotentiator for preventing and treating newcastle diseases | |
| CN102552657B (en) | Chinese medicinal composition used for treating Newcastle disease of chicken | |
| CN105343702A (en) | Traditional Chinese veterinary medicine for preventing and treating avian pox and preparation method of traditional Chinese veterinary medicine | |
| CN103652490A (en) | Pig feed for treating blue-eared pig disease and preparation method thereof | |
| CN105963572A (en) | Traditional Chinese medicine micro-ecological preparation for preventing and treating swine fever and preparation method thereof | |
| CN104547137A (en) | Composite fermented traditional Chinese medicine composition for preventing and treating chicken infectious bursal disease | |
| CN110201088A (en) | A kind of Chinese medicine composition and preparation method thereof of clear and coherent stomach shield stomach | |
| CN104257952B (en) | A kind of Chinese medicine composition for treating chicken coccidiasis | |
| CN103690771B (en) | Be used for the treatment of medicine of lamb colibacillosis and preparation method thereof | |
| CN103341151B (en) | Traditional Chinese medicine for treating chronic bronchitis | |
| CN103690902B (en) | For preventing the Chinese medicine preparation of nasopharyngeal carcinoma radiation side reaction | |
| CN103041172B (en) | Traditional Chinese medicine composition for curing chronic nasosinusitis and preparation method thereof | |
| CN102783570B (en) | Feed for treatment of duck influenza and preparation method thereof | |
| CN105727036A (en) | Traditional Chinese medicinal composition used for treating marek's disease of chicken and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141112 Termination date: 20210425 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |