CN103239667B - Chinese traditional medicine for treating foot-and-mouth disease of domestic animals - Google Patents

Abstract

The invention aims to provide a Chinese traditional medicine for treating foot-and-mouth disease of domestic animals. The Chinese traditional medicine has the advantages of obvious treatment effect, no toxic or side effect, no resistance, economy and effectiveness. The Chinese traditional medicine is characterized by consisting of the following raw materials in parts by weight: 30-40 parts of maize, 30-40 parts of wheat bran, 30-40 parts of glutinous rice, 10-20 parts of ginseng, 10-20 parts of root-bark of Chinese wolfberry, 10-20 parts of mugwort leaf, 20-30 parts of divaricate saposhnikovia root, 1-10 parts of agrimony, 1-10 parts of seed of garden lettuce, 10-20 parts of rhubarb, 10-20 parts of azadirachtaindica folium, 20-30 parts of farfugiumjaponicum, 10-20 parts of rhizomacimicifugae, 10-20 parts of evodiarutaecarpa, 20-30 parts of Chinese thorowax root, 1-10 parts of coastal glehnia root, 10-20 parts of fructuschoerospondiatis, 20-30 parts of galangal, 20-30 parts of symplocossumuntia, 20-30 parts of myrrh, 30-40 parts of herb of Chinese goldsaxifrage, 30-40 parts of loquat leaf, 30-40 parts of ginseng flower and 30-40 parts of medicinal fermented mass.

Description

A kind of Chinese medicine for the treatment of livestock foot-and-mouth disease

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease.

Background technology

The one that the Some Livestocks such as foot and mouth disease is pig, cattle, sheep and other domestic, wild artiodactyl suffer from altogether is acute, hot, high degree in contact sexually transmitted disease, and susceptible animal reaches kind more than 70.Clinical symptoms is in oral mucosa, hoof and skin of breast generation vesicle rash.This sick route of transmission is many, speed is fast, once repeatedly worldwide outbreak of epidemic, causes huge politics, economic loss.Given this, OIE (OIE) is classified as first of category-A infectious disease.At present, have the popular FMD of OIE member state of 2/3rds, the moment threatens safety of livestock without FMD countries and regions and Livestock Product Trade.Foot and mouth disease virus belongs to micro ribonucleic acid Viraceae Hostis.Its largest particles diameter is 23 nanometers, and smallest particles diameter is 7-8 nanometers.

1-7 days incubation periods of this disease, within average 2-4 days, sick cattle spirit is depressed, remains silent, and sialorrhea, has during opening and suck sound, and body temperature can be elevated to 40 1 41 DEG C.Fall ill after 1-2 days, sick Dens Bovis seu Bubali gum, lingual surface, inner aspect of lip can see Semen Viciae fabae to the large vesicle of Semen Juglandis, and saliva liquid increases and is that white foam is hung on mouth.Search for food and ruminate stopping.Vesicle is about broken through diel, and form ulcer, at this moment body temperature can be down to normally gradually.To occur in oral cavity while vesicle or after a while, between toe and on the soft skin of coronet, also vesicle to occur, also can very fast ulceration, then heal gradually.Sometimes on skin of nipple, vesicle is also shown.Primary disease generally in optimum process, got final product spontaneous recovery through about one week; If hoof has pathological changes, can be extended down to for 2-3 weeks or more of a specified duration; Mortality rate 1%--2%, this sick type is optimum foot and mouth disease.Some sick cattle is in vesicle agglutination, and the state of an illness worsens suddenly, and asthenia universalis, muscle are shaken, palpitating speed, irregularity of pulse, appetite is given up absolutely, is ruminated stopping, and walking is waved, astasia, the often sudden death because of cardioplegia, this sick type is pernicious foot and mouth disease, and mortality rate is up to 25% ~ 50%.Often can't see characteristic vesicle during calf morbidity, main manifestations is gastroenteritis haemorrhagica and myocarditis, and mortality rate is high.

Except oral cavity and hoof pathological changes, be also shown in esophagus and cud mucosa has vesicle and speck; Gastrointestinal has hemorrhagic inflammation; Lung is that serosity infiltrates; The a large amount of muddy and liquid of thickness is had in pericardium.Pernicious foot and mouth disease can be seen canescence or faint yellow striped and normal myocardium and go hand in hand on myocardium tangent plane, as Budgerigar shape speckle, is commonly called as " tiger spot heart ".

Summary of the invention

The object of this invention is to provide a kind of therapeutic effect significantly, have no side effect, have no drug resistance, cost-effective a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease.

Treat a Chinese medicine for livestock foot-and-mouth disease, it is characterized in that, be made up of the raw material of following weight portion:

Semen Maydis 30-40 part, Testa Tritici 30-40 part, Oryza glutinosa 30-40 part, Radix Ginseng 10-20 part, Cortex Lycii 10-20 part, Folium Artemisiae Argyi 10-20 part, Radix Saposhnikoviae 20-30 part, Herba Agrimoniae 1-10 part, Semen Lactucae sativae 1-10 part, Radix Et Rhizoma Rhei 10-20 part, Folium meliae 10-20 part, Coniogramme japonica (Thunb.) Diels 20-30 part, Rhizoma Cimicifugae 10-20 part, Fructus Evodiae 10-20 part, Radix Bupleuri 20-30 part, Radix Glehniae 1-10 part, Fructus Choerospondiatis 10-20 part, Rhizoma Alpiniae Officinarum 20-30 part, mountain vitriol 20-30 part, Myrrha 20-30 part, Chrysosplenium grayanum Maxim. 30-40 part, Folium Eriobotryae 30-40 part, Flos Ginseng 30-40 part, Massa Medicata Fermentata 30-40 part,

Preparation method:

By formula proportion by extracting and developing, drying, the pulverizing routinely of above composition, composite in proportion, can be made into tablet, capsule, oral formulations after mix homogeneously, drying, oral administration, during control once a day, treatments period every day three times, each 20-30g.

Treat a Chinese medicine for livestock foot-and-mouth disease, it is characterized in that, be made up of the raw material of following weight portion:

Semen Maydis 32-38 part, Testa Tritici 32-38 part, Oryza glutinosa 32-38 part, Radix Ginseng 12-18 part, Cortex Lycii 12-18 part, Folium Artemisiae Argyi 12-18 part, Radix Saposhnikoviae 22-28 part, Herba Agrimoniae 2-8 part, Semen Lactucae sativae 2-8 part, Radix Et Rhizoma Rhei 12-18 part, Folium meliae 12-18 part, Coniogramme japonica (Thunb.) Diels 22-28 part, Rhizoma Cimicifugae 12-18 part, Fructus Evodiae 12-18 part, Radix Bupleuri 22-28 part, Radix Glehniae 2-8 part, Fructus Choerospondiatis 12-18 part, Rhizoma Alpiniae Officinarum 22-28 part, mountain vitriol 22-28 part, Myrrha 22-28 part, Chrysosplenium grayanum Maxim. 32-38 part, Folium Eriobotryae 32-38 part, Flos Ginseng 32-38 part, Massa Medicata Fermentata 32-38 part.

Treat a Chinese medicine for livestock foot-and-mouth disease, it is characterized in that, be made up of the raw material of following weight portion:

Semen Maydis 35 parts, Testa Tritici 35 parts, 35 parts, Oryza glutinosa, Radix Ginseng 15 parts, Cortex Lycii 15 parts, Folium Artemisiae Argyi 15 parts, Radix Saposhnikoviae 25 parts, Herba Agrimoniae 5 parts, Semen Lactucae sativae 5 parts, Radix Et Rhizoma Rhei 15 parts, Folium meliae 15 parts, Coniogramme japonica (Thunb.) Diels 25 parts, Rhizoma Cimicifugae 15 parts, Fructus Evodiae 15 parts, Radix Bupleuri 25 parts, Radix Glehniae 5 parts, Fructus Choerospondiatis 15 parts, Rhizoma Alpiniae Officinarum 25 parts, mountain vitriol 25 parts, Myrrha 25 parts, Chrysosplenium grayanum Maxim. 35 parts, Folium Eriobotryae 35 parts, Flos Ginseng 35 parts, Massa Medicata Fermentata 35 parts.

the present invention relates to pharmacology and the property of medicine of Chinese medicine:

semen Maydis:

[nature and flavor] sweet in the mouth, property are flat, nontoxic.

[effect] cures mainly dribbling urination and urinary stone, hurt like hell, it is decocted and drinks continuously several times at soup.

It is the class that nutritive value is the highest.Vitamin content be rice, 5-10 times of Semen Tritici aestivi.Also containing various trace elements is that other rice can not be compared.Dietary fiber Semen Maydis contains abundant cellulose, not only can stimulate enterokinesia, prevent constipation, can also promote the metabolism of cholesterol, accelerates the discharge of enterogenous endotoxin.

Semen Maydis is all precious from head to foot:

Vitamin A and vitamin E Semen Maydis contain vitamin A and vitamin E and glutamic acid etc.Zoopery proves, these compositions have anti-aging effects.

The Semen Maydis oil that unsaturated fatty acid corn germ is squeezed out contains a large amount of unsaturated fatty acid, and its Linoleic acid accounts for 60%, can remove cholesterol harmful in blood, atherosclerosis.Nutrient substance contained by corn germ point has enhancing human metabolism, adjustment nervous function.

Someone investigated, Africa be engaged in agriculture work women take Semen Maydis as staple food, the probability that they suffer from intestinal cancer is very low, and visible Semen Maydis has protective effect on cancer risk.In addition, Semen Maydis is more than 5 times of Semen sojae atricolor containing the amount of carotene, also has inhibitory action to carcinogen.

Nutrient Semen Maydis contains lysine, trace element-selenium, has the effect of prophylaxis of tumours.

Vitamin B group Semen Maydis is also containing abundant vitamin B group, nicotinic acid etc., and to neuroprotective conduction and gastrointestinal function, prevention foot disorder of QI, myocarditis, safeguard that skin fitness is effective.

Other Stigma Maydis have stronger diuresis function, have therapeutical effect to urinary system infection, edema, and all right clearing heat secreting bile calculus, is applicable to liver gallbladder damp-heat type cholelithiasis etc.

Testa Tritici:

[nature and flavor] are sweet, cold, nontoxic;

[function cures mainly] controls sweating due to debility, and profit let out by night sweat, diabetes, stomatitis, herpes simplex, injured, rheumatic arthralgia, beriberi.1. supplement to the Herbal: " dough-making powder makes cake, and stopping leak profit, reduces phlegm and internal heat in tune, strong people.Mix steaming with vinegar, bag is contained, and presses waist feet wound folding place, pain-relieving powder for treating blood.Disease herpes simplex when " 2. " Japan hanako materia medica ": " is controlled, sore due to scald and burn is rotten, flutters damage folding, blood stasis, and vinegar is fried and pasted basement." 3. " detailed outline ": " steaming with vinegar presses brothers' rheumatic arthralgia, the disturbance of lower legs due to pathogenic cold and dampness, and reciprocity is to sweating.End clothes only sweating due to debility."

Oryza glutinosa:

[meridian distribution of property and flavor] sweet in the mouth, warm in nature, enter spleen, stomach, lung meridian;

[function] has invigorating the spleen and replenishing QI, strengthening the spleen and nourishing the stomach, only effect of sweating due to debility.Population can eat.Oryza glutinosa contains protein, fat, saccharide, calcium, phosphorus, ferrum, vitamin B1, support one's family rope B2, nicotinic acid and starch etc., nutritious, is the strong food of temperature compensation, there is invigorating the spleen and replenishing QI, strengthening the spleen and nourishing the stomach, only effect of sweating due to debility, to being off one's feed, abdominal distention diarrhoea has certain mitigation.

Flos Ginseng:

[nature and flavor]: bitterness Hui Tian, have the pungent sweet taste of Radix Ginseng.

[function]: supplement vitality of human body, regain one's strength, strengthens body immunity.

Radix Ginseng:

[nature and flavor] sweet, micro-hardship, flat; Return spleen, lung, heart channel.

[function cures mainly] strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.

Folium Artemisiae Argyi:

[meridian distribution of property and flavor] is bitter and pungent, raw temperature, ripe heat; Enter foot lunar, the moon that falls, shaoyin channel.

[effect] regulates the flow of vital energy blood, by cold-damp; Warming the meridian, hemostasis, antiabortive.Cure mainly: trusted subordinate's cold type of pain, convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies.

Cortex Lycii:

[nature and flavor] sweet in the mouth, cold;

[function cures mainly] heat clearing away, removing heat from blood; Asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.

Radix Saposhnikoviae:

[meridian distribution of property and flavor] taste acrid, sweet, warm; Return bladder, liver, spleen channel.

[function cures mainly] inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.

Herba Agrimoniae:

[meridian distribution of property and flavor] toil, flat, enter lung, liver, spleen channel;

[effect] hemostasis, stomach invigorating; Cure mainly: spitting of blood, haematemesis, hematuria, to have blood in stool, Soviet Union doctor " Chinese herbal medicine handbook " records to be decocted in water for oral dose with raw tortoise plastron etc. and controlled anaphylactoid purpura effect.

Semen Lactucae sativae:

[meridian distribution of property and flavor] bitter in the mouth, cold in nature; Enter stomach, urinary bladder channel.

Milk under [function cures mainly], diuresis.Control swelling of the vulva, anal fistula and puerperal galactostasis.

Radix Et Rhizoma Rhei:

[meridian distribution of property and flavor] bitter in the mouth, cold; Return spleen, stomach, large intestine, liver, pericardium channel.

[function cures mainly] purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gums swells.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.

Folium meliae:

[meridian distribution of property and flavor] " Guangdong Chinese medicine " II: " bitter, cold, slightly poisonous." liver, lung, large intestine three warp.

[function] pain relieving, parasite killing.Control hernia, ascarid, treating swelling and pain by traumatic injury, furuncle, skin eczema.

Coniogramme japonica (Thunb.) Diels:

[another name]: Farfugium japonicum (L) Kitam.Liguaria Kaempferi Kino.

Hubei, Hunan claim: golden cup broad-mouthed receptacle for holding liquid, Typhonium divaricatum (L.) Decne

Fujian claims: Farfugium kaemferi, the ferrum winter Herba Amaranthi tricoloris, large Horse hoof, large Herba Asari, Horse hoof Radix Angelicae Sinensis, a leaf lotus;

[meridian distribution of property and flavor] pungent, sweet, micro-hardship, cool.

[function cures mainly] promoting blood circulation and hemostasis, mass dissipating and swelling eliminating.For spitting of blood of coughing, have blood in stool, menoxenia, traumatic injury, mastitis, carbuncle furuncle and phyma poison.

[medicinal effects]: herb or root are used as medicine, the whole year can adopt.

[action and efficacy]: nature and flavor are bitter, cold, nontoxic. promoting flow of QI and blood, removing blood stasis with potent drugs is subsided a swelling, heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation.

Rhizoma Cimicifugae:

[meridian distribution of property and flavor] is sweet, pungent, cool.Return spleen, stomach, large intestine channel.

[drug effect] relieve internal heat anticancer, rash is antipyretic, doctor's skin ulcer eliminating carbuncle.

Fructus Evodiae:

[meridian distribution of property and flavor] is warm in nature, acrid in the mouth, hardship,

[function cures mainly] warming middle-JIAO to relieve pain, dry temperature of regulating the flow of vital energy, is applicable to abdominal distention, vomiting and diarrhoea, singultus acid regurgitation, headache, colic, menstrual pain.

Radix Bupleuri:

Meridian distribution of property and flavor: cold nature, bitter in the mouth, pungent, return Liver Channel, lung meridian, spleen channel.

Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.

Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.

Radix Glehniae: sweetness and bitterness is light is cool.Enter lung, spleen channel.Function cures mainly: nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough.Control lung-heat type cough, chronic consumptive disease chronic cough, the moon hinders dry pharynx, thirsty.

Rhizoma Alpiniae Officinarum:

[meridian distribution of property and flavor] is pungent, heat.Return spleen, stomach warp.

[function cures mainly] warming stomach for dispelling cold, help digestion pain relieving.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.

Fructus Choerospondiatis:

[meridian distribution of property and flavor] is sweet, sour, flat.

[function] promoting flow of QI and blood, nourishes heart, calms the nerves, resist myocardial ischemia, the effects such as cardiac function protecting.For qi depression to blood stasis, the thoracic obstruction is had a pain, shortness of breath and palpitation, irritability.

Mountain vitriol:

[nature and flavor] are pungent, bitter, flat.

[function cures mainly] clearing away heat-damp and promoting diuresis, activating QI to eliminate phlegm.Cure mainly jaundice, cough, arthritis.External treating acute tonsillitis, thrush.　

Myrrha:

[nature and flavor] are bitter, pungent, flat.

[function] is antibacterial, antimicrobial, antiinflammatory, convergence, tool balosam speciality, deodorization, flatulence of dispelling, sterilization, diuresis, stimulate the menstrual flow, reduce phlegm, antifungal, excitation, sharp stomach, urge antiperspirant, mend body, sharp uterus, control wound, to ripe dry and cracked to take off coarse skin helpful.

Chrysosplenium grayanum Maxim.:

[meridian distribution of property and flavor] bitter, cool enter heart channel.

The heat clearing away of [effect] dampness, controls carbuncle furuncle, eczema." will planted by Tianmu Mountains of Zhejiang Province medicine ": control furuncle.

Folium Eriobotryae:

[meridian distribution of property and flavor] bitter, be slightly cold; Return lung, stomach warp.

[function] Folium Eriobotryae fermented product: ursolic acid 25%, ursolic acid 30%, ursolic acid 90%, ursolic acid 95%, ursolic acid 98.Folium Eriobotryae extractum, has the effects such as heat clearing away, lung moistening, relieving cough and resolving phlegm; Steam again its leaf and get dew, be named " Liquor Folium Eriobotryae Distillata ", have heat clearing away, separate the effect such as summer-heat, stomach function regulating; Be fabulous nectariferous plant again, in Mel, " Loquat Honey " is of fine quality.Leaf is containing soap twenty, amygdaloside, maloic acid, oleanolic acid, tannin, vitamin B l, vitamin C etc.

Massa Medicata Fermentata:

[nature and flavor] are bitter, temperature; 1. the property of medicine is examined: micro-bitter fragrant sweet; 2. detailed outline is picked up any lost article from the road: sweet light, delicate fragrance.

[function] removing dampness by means of aromatics, dispelling wind to relieve the exterior syndrome, digesting and appetizing.For Common Cold, summertime heatstroke, heating of being afraid of cold, headache general pain, vomiting and diarrhoea, dyspepsia, abdominal distention uncomfortable in chest.

detailed description of the invention:

Embodiment 1, formula:

Semen Maydis 30g, Testa Tritici 30g, Oryza glutinosa 30g, Radix Ginseng 10g, Cortex Lycii 10g, Folium Artemisiae Argyi 10g, Radix Saposhnikoviae 20g, Herba Agrimoniae 1g, Semen Lactucae sativae 1g, Radix Et Rhizoma Rhei 10g, Folium meliae 10g, Coniogramme japonica (Thunb.) Diels 20g, Rhizoma Cimicifugae 10g, Fructus Evodiae 10g, Radix Bupleuri 20g, Radix Glehniae 1g, Fructus Choerospondiatis 10g, Rhizoma Alpiniae Officinarum 20g, mountain vitriol 20g, Myrrha 20g, Chrysosplenium grayanum Maxim. 30g, Folium Eriobotryae 30g, Flos Ginseng 30g, Massa Medicata Fermentata 30-40g;

Preparation method:

By formula proportion by extracting and developing, drying, the pulverizing routinely of above composition, composite in proportion, can be made into tablet, capsule, oral formulations after mix homogeneously, drying, oral administration, during control once a day, treatments period every day three times, each 20-30g.

Embodiment 2, formula:

Semen Maydis 32g, Testa Tritici 32g, Oryza glutinosa 32g, Radix Ginseng 12g, Cortex Lycii 12g, Folium Artemisiae Argyi 12g, Radix Saposhnikoviae 22g, Herba Agrimoniae 2g, Semen Lactucae sativae 2g, Radix Et Rhizoma Rhei 12g, Folium meliae 12g, Coniogramme japonica (Thunb.) Diels 22g, Rhizoma Cimicifugae 12g, Fructus Evodiae 12g, Radix Bupleuri 22g, Radix Glehniae 2g, Fructus Choerospondiatis 12g, Rhizoma Alpiniae Officinarum 22g, mountain vitriol 22g, Myrrha 22g, Chrysosplenium grayanum Maxim. 32g, Folium Eriobotryae 32g, Flos Ginseng 32g, Massa Medicata Fermentata 32g.

Preparation method is identical with embodiment 1.

Embodiment 3, formula:

Semen Maydis 35g, Testa Tritici 35g, Oryza glutinosa 35g, Radix Ginseng 15g, Cortex Lycii 15g, Folium Artemisiae Argyi 15g, Radix Saposhnikoviae 25g, Herba Agrimoniae 5g, Semen Lactucae sativae 5g, Radix Et Rhizoma Rhei 15g, Folium meliae 15g, Coniogramme japonica (Thunb.) Diels 25g, Rhizoma Cimicifugae 15g, Fructus Evodiae 15g, Radix Bupleuri 25g, Radix Glehniae 5g, Fructus Choerospondiatis 15g, Rhizoma Alpiniae Officinarum 25g, mountain vitriol 25g, Myrrha 25g, Chrysosplenium grayanum Maxim. 35g, Folium Eriobotryae 35g, Flos Ginseng 35g, Massa Medicata Fermentata 35g.

Preparation method is identical with embodiment 1.

Embodiment 4, formula:

Semen Maydis 38g, Testa Tritici 38g, Oryza glutinosa 38g, Radix Ginseng 18g, Cortex Lycii 18g, Folium Artemisiae Argyi 18g, Radix Saposhnikoviae 28g, Herba Agrimoniae 8g, Semen Lactucae sativae 8g, Radix Et Rhizoma Rhei 18g, Folium meliae 18g, Coniogramme japonica (Thunb.) Diels 28g, Rhizoma Cimicifugae 18g, Fructus Evodiae 18g, Radix Bupleuri 28g, Radix Glehniae 8g, Fructus Choerospondiatis 18g, Rhizoma Alpiniae Officinarum 28g, mountain vitriol 28g, Myrrha 28g, Chrysosplenium grayanum Maxim. 38g, Folium Eriobotryae 38g, Flos Ginseng 38g, Massa Medicata Fermentata 38g.

Preparation method is identical with embodiment 1.

Embodiment 5, formula:

Semen Maydis 40g, Testa Tritici 40g, Oryza glutinosa 40g, Radix Ginseng 20g, Cortex Lycii 20g, Folium Artemisiae Argyi 20g, Radix Saposhnikoviae 30g, Herba Agrimoniae 10g, Semen Lactucae sativae 10g, Radix Et Rhizoma Rhei 20g, Folium meliae 20g, Coniogramme japonica (Thunb.) Diels 30g, Rhizoma Cimicifugae 20g, Fructus Evodiae 20g, Radix Bupleuri 30g, Radix Glehniae 10g, Fructus Choerospondiatis 20g, Rhizoma Alpiniae Officinarum 30g, mountain vitriol 30g, Myrrha 30g, Chrysosplenium grayanum Maxim. 40g, Folium Eriobotryae 40g, Flos Ginseng 40g, Massa Medicata Fermentata 40g;

Preparation method:

By formula proportion by extracting and developing, drying, the pulverizing routinely of above composition, composite in proportion, can be made into tablet, capsule, oral formulations after mix homogeneously, drying, oral administration, during control once a day, treatments period every day three times, each 20-30g.

chinese medicine composition of the present invention is to the acute toxicity test of mice

Experimental animal

The healthy KM mice of SPF level, 30, male and female half and half, body weight 20-25g; Purchased from Sichuan Provincial Academy of Traditional Chinese Medicine Experimental Animal Center

Test method

After the adaptabilities of 3 days are raised, be divided at random 5 groups (male and female half and half), often organize each 10; Matched group, 4 various dose groups (be only respectively 76mg/, only, only, 357.6mg/ only for 219.9mg/ for 152.1mg/).Mice free choice feeding, drinking-water, in feeding process, every day changes water, the next day change bedding and padding.Whole experimental period is 7 days.

6. testing index and method

(1) clinicing symptom observation: every day viewing test Mus the mental status, diet situation, every day entry morbidity death condition.

(2) pathological observation: dead Mus is carried out cuing open inspection and observes internal organs change.

(3) growth indexes is observed: carry out routine weighing to test Mus; Off-test, slaughters that Mus weighs in, the heavy organ index of internal organs measures: cut open inspection kunming mice, core dirty, spleen, liver, kidney, testis, ovary, weigh, calculate organ index according to the following formula: organ index=internal organs weight/body weight × 100.

(4) liver function change is observed: after off-test, slaughter Mus, take blood separation serum, measures AST, ALT.

7. date processing: above data acquisition SPSS11.0 carries out analytic statistics.

Clinicing symptom observation

Matched group and test group Mus, the mental status and diet wish, to external world respond have no obvious exception.Each group of Mus morbidity and death condition are as following table 1.

Table 1

Pathological observation: matched group and test group, Mus carries out cuing open inspection and observes to have no and observe the obvious pathological change of internal organs after slaughtering.

Growth indexes is observed: off-test, slaughters that Mus weighs in, internal organs weight analysis is in table 2.

Table 2

Liver function change is observed

After off-test, slaughter Mus, take blood separation serum, measure AST, ALT in table 3.It is not remarkable that result shows each group of data difference compared with normal healthy controls group, is all in normal range.

Table 3

Clinical experiment 1

By 360 healthy cattle (male and female half and half, body weight is between 150kg ~ 200kg) be divided into three groups at random, group I is counteracting toxic substances matched group, group II is the test group taking the rear counteracting toxic substances of the obtained Chinese medicine composition 1 of embodiment 3, group III is the test group taking the rear counteracting toxic substances of the obtained Chinese medicine composition 2 of embodiment 4, group I only feeds with normal feedstuff Semen Tritici aestivi, and every day every, Chinese medicine composition that cattle is joined was suitable with 1.5 grams of raw material of Chinese medicine doses; Each group of cattle free choice feeding, drinking-water, Routine Management; Raise identical natural law, disease cattle symptom is observed during 9:00 and 16:00 every day, dead cattle is only weighed, anatomic observation pathological change, and perform itemized record, carry out only weighing to not dead cattle, dissecting for ten days to test, and recorded pathological changes situation, after having tested, carry out data statistics to test mortality rate, effective percentage, concrete outcome is in table 4.

Table 4

In this experimentation, allly there is symptom of the present invention and dead at duration of test, the ill apparition person of necropsy, be judged to infect dead.

Effectively after medication, not ill cattle be only effectively, and often organizing healthy cattle number, to account for the percentage rate testing cattle number be effective percentage.

From table 4, we can find out, adopt Chinese medicine composition of the present invention to have significant preventive effect to cattle Sudden Death Syndrome.

Clinical experiment 2

By 480 health pig (male and female half and half, body weight is between 100kg ~ 200kg) be divided into four groups at random, group I is counteracting toxic substances matched group, group II is the test group taking the rear counteracting toxic substances of the obtained Chinese medicine composition 1 of embodiment 1, group III is the test group taking the rear counteracting toxic substances of the obtained Chinese medicine composition 2 of embodiment 2, group IIII is the test group taking the rear counteracting toxic substances of the obtained Chinese medicine composition 2 of embodiment 2, group I only feeds with normal feedstuff Semen Tritici aestivi, and every day every, Chinese medicine composition that pig is joined was suitable with 1.5 grams of raw material of Chinese medicine doses; Each group of pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, disease pig symptom is observed during 9:00 and 16:00 every day, dead pig is weighed, anatomic observation pathological change, and perform itemized record, carry out weighing to not dead pig, dissecting for ten days to test, and recorded pathological changes situation, after having tested, carry out data statistics to test mortality rate, effective percentage, concrete outcome is in table 5.

Table 5

In this experimentation, allly there is symptom of the present invention and dead at duration of test, the ill apparition person of necropsy, be judged to infect dead.

Effectively after medication, not ill pig is effectively, and often group health pig number accounts for the percentage rate of test pig number is effective percentage.

From table 5, we can find out, adopt Chinese medicine composition of the present invention to have significant preventive effect to pig Sudden Death Syndrome.

the invention has the beneficial effects as follows:

The all medicine conjunctive use of the present invention, benefiting QI for strengthening the superficies, strengthening the spleen and stomach, positive effect is had to oral mucosa, hoof and skin of breast generation vesicle rash prevention and therapy, have no side effect, have no drug resistance, economical and effective is convenient is worth application, invention formulation can not by stomach acids destroy, direct arrival intestinal slow releasing is also acted on the normal immunological function nursing one's health cattle body, successful by absorbing.

Claims (2)

1. treating a Chinese medicine for livestock foot-and-mouth disease, it is characterized in that, is be made up of the raw material of following weight portion:

Semen Maydis 30-40 part, Testa Tritici 30-40 part, Oryza glutinosa 30-40 part, Radix Ginseng 10-20 part, Cortex Lycii 10-20 part, Folium Artemisiae Argyi 10-20 part, Radix Saposhnikoviae 20-30 part, Herba Agrimoniae 1-10 part, Semen Lactucae sativae 1-10 part, Radix Et Rhizoma Rhei 10-20 part, Folium meliae 10-20 part, Coniogramme japonica (Thunb.) Diels 20-30 part, Rhizoma Cimicifugae 10-20 part, Fructus Evodiae 10-20 part, Radix Bupleuri 20-30 part, Radix Glehniae 1-10 part, Fructus Choerospondiatis 10-20 part, Rhizoma Alpiniae Officinarum 20-30 part, mountain vitriol 20-30 part, Myrrha 20-30 part, Chrysosplenium grayanum Maxim. 30-40 part, Folium Eriobotryae 30-40 part, Flos Ginseng 30-40 part, Massa Medicata Fermentata 30-40 part,

Preparation method:

By formula proportion by extracting and developing, drying, the pulverizing routinely of above composition, composite in proportion, can be made into tablet, capsule, oral administration after mix homogeneously, drying, during control once a day, treatments period every day three times, each 20-30g.

2. a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease according to claim 1, is characterized in that, is be made up of the raw material of following weight portion:

Semen Maydis 32-38 part, Testa Tritici 32-38 part, Oryza glutinosa 32-38 part, Radix Ginseng 12-18 part, Cortex Lycii 12-18 part, Folium Artemisiae Argyi 12-18 part, Radix Saposhnikoviae 22-28 part, Herba Agrimoniae 2-8 part, Semen Lactucae sativae 2-8 part, Radix Et Rhizoma Rhei 12-18 part, Folium meliae 12-18 part, Coniogramme japonica (Thunb.) Diels 22-28 part, Rhizoma Cimicifugae 12-18 part, Fructus Evodiae 12-18 part, Radix Bupleuri 22-28 part, Radix Glehniae 2-8 part, Fructus Choerospondiatis 12-18 part, Rhizoma Alpiniae Officinarum 22-28 part, mountain vitriol 22-28 part, Myrrha 22-28 part, Chrysosplenium grayanum Maxim. 32-38 part, Folium Eriobotryae 32-38 part, Flos Ginseng 32-38 part, Massa Medicata Fermentata 32-38 part.

3 .a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease according to claim 1, is characterized in that, is be made up of the raw material of following weight portion:

Semen Maydis 35 parts, Testa Tritici 35 parts, 35 parts, Oryza glutinosa, Radix Ginseng 15 parts, Cortex Lycii 15 parts, Folium Artemisiae Argyi 15 parts, Radix Saposhnikoviae 25 parts, Herba Agrimoniae 5 parts, Semen Lactucae sativae 5 parts, Radix Et Rhizoma Rhei 15 parts, Folium meliae 15 parts, Coniogramme japonica (Thunb.) Diels 25 parts, Rhizoma Cimicifugae 15 parts, Fructus Evodiae 15 parts, Radix Bupleuri 25 parts, Radix Glehniae 5 parts, Fructus Choerospondiatis 15 parts, Rhizoma Alpiniae Officinarum 25 parts, mountain vitriol 25 parts, Myrrha 25 parts, Chrysosplenium grayanum Maxim. 35 parts, Folium Eriobotryae 35 parts, Flos Ginseng 35 parts, Massa Medicata Fermentata 35 parts.