CN103239667A - Chinese traditional medicine for treating foot-and-mouth disease of domestic animals - Google Patents

Abstract

The invention aims to provide a Chinese traditional medicine for treating foot-and-mouth disease of domestic animals. The Chinese traditional medicine has the advantages of obvious treatment effect, no toxic or side effect, no resistance, economy and effectiveness. The Chinese traditional medicine is characterized by consisting of the following raw materials in parts by weight: 30-40 parts of maize, 30-40 parts of wheat bran, 30-40 parts of glutinous rice, 10-20 parts of ginseng, 10-20 parts of root-bark of Chinese wolfberry, 10-20 parts of mugwort leaf, 20-30 parts of divaricate saposhnikovia root, 1-10 parts of agrimony, 1-10 parts of seed of garden lettuce, 10-20 parts of rhubarb, 10-20 parts of azadirachtaindica folium, 20-30 parts of farfugiumjaponicum, 10-20 parts of rhizomacimicifugae, 10-20 parts of evodiarutaecarpa, 20-30 parts of Chinese thorowax root, 1-10 parts of coastal glehnia root, 10-20 parts of fructuschoerospondiatis, 20-30 parts of galangal, 20-30 parts of symplocossumuntia, 20-30 parts of myrrh, 30-40 parts of herb of Chinese goldsaxifrage, 30-40 parts of loquat leaf, 30-40 parts of ginseng flower and 30-40 parts of medicinal fermented mass.

Description

A kind of Chinese medicine for the treatment of livestock foot-and-mouth disease

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease.

Background technology

Foot and mouth disease is a kind of acute, hot, the height contagious disease that main domestic animal such as pig, cattle, sheep and other domestic, wild artiodactyl suffer from altogether, and susceptible animal reaches kind more than 70.Clinical symptoms is in oral mucosa, hoof and skin of breast generation vesicle rash.This disease route of transmission is many, speed is fast, and once outbreak of epidemic worldwide repeatedly caused huge politics, economic loss.Given this, OIE (OIE) classifies it first of category-A infectious disease as.At present, 2/3rds the popular FMD of OIE member state is arranged, threatening safety of livestock and the Livestock Product Trade of not having the FMD countries and regions constantly.Foot and mouth disease virus belongs to micro ribonucleic acid Viraceae Hostis.Its largest particles diameter is 23 nanometers, and the smallest particles diameter is 7-8 nanometers.

1-7 days incubation periods of this disease, sick cattle spirit was depressed in average 2-4 days, remained silent, and sialorrhea has the sound of sucking during opening, and body temperature can be elevated to 40 1 41 ℃.Fall ill after 1-2 days, sick Dens Bovis seu Bubali gum, lingual surface, inner aspect of lip can be seen Semen Viciae fabae to the big vesicle of Semen Juglandis, and saliva liquid increases and the cystose that is white in color is hung on the mouth.Search for food and ruminate and stop.Vesicle is broken through diel approximately, forms ulcer, and at this moment body temperature can be down to normally gradually.When vesicle takes place in the oral cavity or after a while, between toe and on the soft skin of coronet vesicle takes place also, also can very fast ulceration, healing gradually then.Sometimes on skin of nipple, also can see vesicle.Primary disease generally is optimum process, gets final product spontaneous recovery through about a week; If hoof has pathological changes then to can be extended down to for 2-3 weeks or more of a specified duration; Mortality rate 1%--2%, this disease type is optimum foot and mouth disease.Some sick cattle is in the vesicle agglutination, and the state of an illness worsens suddenly, and asthenia universalis, muscle are shaken, palpitating speed, irregularity of pulse, appetite is useless exhausted, ruminate and stop, and walking is waved, astasia, often because of heart paralysis sudden death, this sick type is pernicious foot and mouth disease, and mortality rate is up to 25% ~ 50%.Calf often be can't see the characteristic vesicle during morbidity, mainly shows as gastroenteritis haemorrhagica and myocarditis, and mortality rate is high.

Except oral cavity and hoof pathological changes, be also shown in esophagus and the cud mucosa has vesicle and speck; Gastrointestinal has hemorrhagic inflammation; Lung is serosity and soaks into; A large amount of muddinesses are arranged and the liquid of thickness in the pericardium.Pernicious foot and mouth disease can be seen canescence or faint yellow striped and normal myocardium at myocardium tangent plane and go hand in hand, and as Budgerigar shape speckle, is commonly called as " tiger spot heart ".

Summary of the invention

The purpose of this invention is to provide a kind of therapeutic effect significantly, have no side effect, have no drug resistance, cost-effective a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease.

A kind of Chinese medicine for the treatment of livestock foot-and-mouth disease is characterized in that, is made up of the raw material of following weight portion:

Corn 30-40 part, Testa Tritici 30-40 part, Oryza glutinosa 30-40 part, Radix Ginseng 10-20 part, Cortex Lycii 10-20 part, Folium Artemisiae Argyi 10-20 part, Radix Saposhnikoviae 20-30 part, Herba Agrimoniae 1-10 part, Semen Lactucae sativae 1-10 part, Radix Et Rhizoma Rhei 10-20 part, Folium meliae 10-20 part, Coniogramme japonica (Thunb.) Diels 20-30 part, Rhizoma Cimicifugae 10-20 part, Fructus Evodiae 10-20 part, Radix Bupleuri 20-30 part, Radix Glehniae 1-10 part, Fructus Choerospondiatis 10-20 part, Rhizoma Alpiniae Officinarum 20-30 part, mountain vitriol 20-30 part, Myrrha 20-30 part, Chrysosplenium grayanum Maxim. 30-40 part, Folium Eriobotryae 30-40 part, Flos Ginseng 30-40 part, Massa Medicata Fermentata 30-40 part;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations after mix homogeneously, the drying, oral administration, during the control once a day, every day three times during the treatment, each 20-30g.

A kind of Chinese medicine for the treatment of livestock foot-and-mouth disease is characterized in that, is made up of the raw material of following weight portion:

Corn 32-38 part, Testa Tritici 32-38 part, Oryza glutinosa 32-38 part, Radix Ginseng 12-18 part, Cortex Lycii 12-18 part, Folium Artemisiae Argyi 12-18 part, Radix Saposhnikoviae 22-28 part, Herba Agrimoniae 2-8 part, Semen Lactucae sativae 2-8 part, Radix Et Rhizoma Rhei 12-18 part, Folium meliae 12-18 part, Coniogramme japonica (Thunb.) Diels 22-28 part, Rhizoma Cimicifugae 12-18 part, Fructus Evodiae 12-18 part, Radix Bupleuri 22-28 part, Radix Glehniae 2-8 part, Fructus Choerospondiatis 12-18 part, Rhizoma Alpiniae Officinarum 22-28 part, mountain vitriol 22-28 part, Myrrha 22-28 part, Chrysosplenium grayanum Maxim. 32-38 part, Folium Eriobotryae 32-38 part, Flos Ginseng 32-38 part, Massa Medicata Fermentata 32-38 part.

A kind of Chinese medicine for the treatment of livestock foot-and-mouth disease is characterized in that, is made up of the raw material of following weight portion:

35 parts of corns, 35 parts of Testa Triticis, 35 parts in Oryza glutinosa, 15 parts of Radix Ginsengs, 15 parts of Cortex Lycii, 15 parts of Folium Artemisiae Argyis, 25 parts of Radix Saposhnikoviaes, 5 parts of Herba Agrimoniaes, 5 parts of Semen Lactucae sativae, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Folium meliae, 25 parts of Coniogramme japonica (Thunb.) Diels, 15 parts of Rhizoma Cimicifugaes, 15 parts of Fructus Evodiaes, 25 parts of Radix Bupleuri, 5 parts of Radix Glehniaes, 15 parts of Fructus Choerospondiatis, 25 parts of Rhizoma Alpiniae Officinarums, 25 parts of mountain vitriol, 25 parts of Myrrhas, 35 parts of Chrysosplenium grayanum Maxim., 35 parts of Folium Eriobotryaes, 35 parts of Flos Ginseng, 35 parts of Massa Medicata Fermentata.

The present invention relates to pharmacology and the property of medicine of Chinese medicine:

Corn:

[nature and flavor] sweet in the mouth, property are put down, and be nontoxic.

[effect cures mainly] cures mainly dribbling urination and urinary stone, and pain is fried in shallow oil it at soup and drunk several times continuously unbearably.

It is the highest class of nutritive value.Vitamin content is rice, Semen Tritici aestivi 5-10 times.Also containing various trace elements is that other rice can not be compared.The dietary fiber corn contains abundant cellulose, not only can stimulate enterokinesia, prevents constipation, can also promote the metabolism of cholesterol, accelerates the discharge of enterogenous endotoxin.

Corn all is precious from head to foot:

Vitamin A and vitamin E corn contain vitamin A and vitamin E and glutamic acid etc.Zoopery proves that these compositions have anti-aging effects.

The Semen Maydis oil that the unsaturated fatty acid corn germ is squeezed out contains a large amount of unsaturated fatty acids, and wherein linoleic acid accounts for 60%, can remove cholesterol harmful in the blood, prevents atherosclerosis.The contained nutrient substance of corn germ point has the human body of enhancing metabolism, adjusts nervous function.

Someone investigated, and the be engaged in agriculture women of work of Africa is staple food with the corn, and the probability that they suffer from intestinal cancer is very low, and visible corn has protective effect on cancer risk.In addition, the amount that corn contains carotene is more than 5 times of Semen sojae atricolor, and carcinogen is also had inhibitory action.

The nutrient corn contains lysine, trace element-selenium, and the effect of prophylaxis of tumours is arranged.

The vitamin B group corn also contains abundant vitamin B group, nicotinic acid etc., and to neuroprotective conduction and gastrointestinal function, prevention vitamin B1 deficiency, myocarditis safeguard that skin fitness is effective.

Other Stigma Maydis have stronger diuresis function, and urinary system infection, edema are had therapeutical effect, and all right clearing heat secreting bile calculus is applicable to liver gallbladder damp-heat type cholelithiasis etc.

Testa Tritici:

[nature and flavor] are sweet, and are cold, nontoxic;

[function cures mainly] controls sweating due to debility, and night sweat is let out profit, diabetes, and stomatitis, herpes simplex, folding is hindered, rheumatic arthralgia, beriberi.1. supplement to the Herbal: " dough-making powder is made cake, and the stopping leak profit is reduced phlegm and internal heat in the accent, strong people.Mix steaming with vinegar, bag is contained, and presses waist feet wound folding place, pain-relieving powder for treating blood." 2. " Japan hanako materia medica ": " disease herpes simplex when controlling, sore due to scald and burn is mashed, pounces on the damage folding, and blood stasis, vinegar are fried and are pasted basement." 3. " detailed outline ": " steaming with vinegar is pressed brothers' rheumatic arthralgia, the disturbance of lower legs due to pathogenic cold and dampness, and reciprocity is to sweating.The end clothes end sweating due to debility."

Oryza glutinosa:

[meridian distribution of property and flavor] sweet in the mouth, warm in nature is gone into spleen, stomach, lung meridian;

[function] has invigorating the spleen and replenishing QI, strengthening the spleen and nourishing the stomach, the effect of ending sweating due to debility.General crowd can both eat.Oryza glutinosa contains protein, fat, saccharide, calcium, phosphorus, ferrum, vitamin B1, support one's family rope B2, nicotinic acid and starch etc., and is nutritious, is the strong food of temperature compensation, has invigorating the spleen and replenishing QI, strengthening the spleen and nourishing the stomach, the effect of ending sweating due to debility, to being off one's feed, abdominal distention diarrhoea has certain mitigation.

The Flos Ginseng:

[nature and flavor]: bitterness Hui Tian has the hot sweet taste of Radix Ginseng.

[function]: replenish human body vigour, regain one's strength, strengthen body immunity.

Radix Ginseng:

[nature and flavor] sweet, little hardship, flat; Return spleen, lung, heart channel.

[function cures mainly] strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.

Folium Artemisiae Argyi:

[meridian distribution of property and flavor] is bitter and hot, gives birth to temperature, ripe heat; Go into lunar, the moon that falls of foot, shaoyin channel.

[effect] blood of regulating the flow of vital energy is by cold-damp; Warming the meridian, hemostasis, antiabortive.Cure mainly: trusted subordinate's cold type of pain, the convulsion of having loose bowels, chronic dysentery is told nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies.

Cortex Lycii:

[nature and flavor] sweet in the mouth, cold;

[function cures mainly] heat clearing away, removing heat from blood; Asthenia hectic fever night sweat, the lung-heat cough with asthma is spitted blood, epistaxis, stranguria with blood is quenched one's thirst, hypertension, carbuncle, malignant boil.

Radix Saposhnikoviae:

[meridian distribution of property and flavor] acrid in the mouth, sweet, temperature; Return bladder, liver, spleen channel.

[function cures mainly] inducing diaphoresis to dispel wind wins and wets, relieving convulsion.Be used for headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.

Herba Agrimoniae:

[meridian distribution of property and flavor] toil, flat is gone into lung, liver, spleen channel;

[effect] hemostasis, stomach invigorating; Cure mainly: spitting of blood, haematemesis, hematuria, have blood in stool, " record of Chinese herbal medicine handbook and raw tortoise plastron etc. have been decocted in water for oral dose and had controlled the anaphylactoid purpura effect doctor of Soviet Union.

Semen Lactucae sativae:

[meridian distribution of property and flavor] bitter in the mouth, cold in nature; Go into stomach, urinary bladder channel.

[function cures mainly] be milk down, diuresis.Control swelling of the vulva, anal fistula and puerperal galactostasis.

Radix Et Rhizoma Rhei:

[meridian distribution of property and flavor] bitter in the mouth, cold; Return spleen, stomach, large intestine, liver, pericardium channel.

[function cures mainly] purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Be used for the conjunctival congestion pharyngeal swelling, gums is swollen.Radix Et Rhizoma Rhei rushes down exerts oneself to delay eliminating fire and detoxication.Be used for pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.Be used for heat in blood stasis of blood hemorrhage is arranged.

Folium meliae:

[meridian distribution of property and flavor] " Guangdong Chinese medicine " II: " hardship, cold, slightly poisonous." liver, lung, large intestine three warps.

[function] pain relieving, parasite killing.Control hernia, ascarid, treating swelling and pain by traumatic injury, furuncle, skin eczema.

Coniogramme japonica (Thunb.) Diels:

[another name]: piemarker herb

Hubei, Hunan claim: golden cup broad-mouthed receptacle for holding liquid, Typhonium divaricatum (L.) Decne

Fujian claims: Farfugium kaemferi, ferrum winter Herba Amaranthi tricoloris, big Horse hoof, big Herba Asari, Horse hoof Radix Angelicae Sinensis, a leaf lotus;

[meridian distribution of property and flavor] hot, sweet, little hardship, cold.

[function cures mainly] promoting blood circulation and hemostasis, mass dissipating and swelling eliminating.Be used for the cough spitting of blood, have blood in stool menoxenia, traumatic injury, mastitis, carbuncle furuncle and phyma poison.

[medicinal part]: herb or root are used as medicine, and can adopt the whole year.

[action and efficacy]: nature and flavor hardship, cold, nontoxic. promoting flow of QI and blood, removing blood stasis with potent drugs detumescence, heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation.

Rhizoma Cimicifugae:

[meridian distribution of property and flavor] is sweet, hot, cool.Return spleen, stomach, large intestine channel.

[drug effect] relieve internal heat anticancer, rash is analgesic, doctor's skin ulcer eliminating carbuncle.

Fructus Evodiae:

[meridian distribution of property and flavor] is warm in nature, acrid in the mouth, hardship,

[function cures mainly] warming middle-JIAO to relieve pain, the dry temperature of regulating the flow of vital energy is applicable to abdominal distention, vomiting and diarrhoea, singultus acid regurgitation, headache, colic, menstrual pain.

Radix Bupleuri:

Meridian distribution of property and flavor: cold nature, bitter in the mouth, suffering, return Liver Channel, lung meridian, spleen channel.

Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.

Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, menoxenia.

Radix Glehniae: sweetness and bitterness is light, cold.Go into lung, spleen channel.Function cures mainly: nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough.Control lung-heat type cough, chronic consumptive disease chronic cough, the moon are hindered dry pharynx, thirsty.

Rhizoma Alpiniae Officinarum:

[meridian distribution of property and flavor] suffering, heat.Return spleen, stomach warp.

[function cures mainly] warming stomach for dispelling cold, pain relieving helps digestion.Be used for coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.

Fructus Choerospondiatis:

[meridian distribution of property and flavor] is sweet, sour, and be flat.

[function] promoting flow of QI and blood nourishes heart, and calms the nerves, and resists myocardial ischemia effects such as cardiac function protecting.Be used for qi depression to blood stasis, the thoracic obstruction is had a pain, shortness of breath and palpitation, irritability.

The mountain vitriol:

[nature and flavor] are hot, bitter, and are flat.

[function cures mainly] clearing away heat-damp and promoting diuresis, activating QI to eliminate phlegm.Cure mainly jaundice, cough, arthritis.The external treating acute tonsillitis, thrush.　

Myrrha:

[nature and flavor] hardship, suffering, flat.

[function] is antibiotic, antimicrobial, antiinflammatory, convergence, tool balosam speciality, deodorization, the flatulence of dispelling, sterilization, diuresis, stimulate the menstrual flow, reduce phlegm, antifungal, excitation, sharp stomach, urge antiperspirant, mend body, sharp uterus, control wound, to ripe dry and cracked to take off coarse skin helpful.

Chrysosplenium grayanum Maxim.:

[meridian distribution of property and flavor] is bitter, heart channel is gone in cold.

Carbuncle furuncle, eczema are controlled in the heat clearing away of [effect cures mainly] dampness." the temmoku Rhizoma Dioscoreae is planted will in Zhejiang ": control furuncle.

Folium Eriobotryae:

[meridian distribution of property and flavor] bitter, be slightly cold; Return lung, the stomach warp.

[function] Folium Eriobotryae fermented product: ursolic acid 25%, ursolic acid 30%, ursolic acid 90%, ursolic acid 95%, ursolic acid 98.Folium Eriobotryae extractum has effects such as heat clearing away, lung moistening, relieving cough and resolving phlegm; Steam its leaf again and get dew, be named " Liquor Folium Eriobotryae Distillata ", heat clearing away is arranged, separate effects such as summer-heat, stomach function regulating; Be fabulous nectariferous plant again, in Mel, " Loquat Honey " is of fine quality.Leaf contains soap twenty, amygdaloside, maloic acid, oleanolic acid, tannin, vitamin B l, vitamin C etc.

Massa Medicata Fermentata:

[nature and flavor] hardship, temperature; 1. the property of medicine is examined: little bitter fragrant sweet; 2. detailed outline is picked up any lost article from the road: sweet light, and delicate fragrance.

[function] removing dampness by means of aromatics, dispelling wind to relieve the exterior syndrome, digesting and appetizing.Be used for Common Cold, summertime heatstroke, the heating of being afraid of cold, headache general pain, vomiting and diarrhoea, dyspepsia, abdominal distention uncomfortable in chest.

The specific embodiment:

Embodiment 1, prescription:

Corn 30g, Testa Tritici 30g, Oryza glutinosa 30g, Radix Ginseng 10g, Cortex Lycii 10g, Folium Artemisiae Argyi 10g, Radix Saposhnikoviae 20g, Herba Agrimoniae 1g, Semen Lactucae sativae 1g, Radix Et Rhizoma Rhei 10g, Folium meliae 10g, Coniogramme japonica (Thunb.) Diels 20g, Rhizoma Cimicifugae 10g, Fructus Evodiae 10g, Radix Bupleuri 20g, Radix Glehniae 1g, Fructus Choerospondiatis 10g, Rhizoma Alpiniae Officinarum 20g, mountain vitriol 20g, Myrrha 20g, Chrysosplenium grayanum Maxim. 30g, Folium Eriobotryae 30g, Flos Ginseng 30g, Massa Medicata Fermentata 30-40g;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations after mix homogeneously, the drying, oral administration, during the control once a day, every day three times during the treatment, each 20-30g.

Embodiment 2, prescription:

Corn 32g, Testa Tritici 32g, Oryza glutinosa 32g, Radix Ginseng 12g, Cortex Lycii 12g, Folium Artemisiae Argyi 12g, Radix Saposhnikoviae 22g, Herba Agrimoniae 2g, Semen Lactucae sativae 2g, Radix Et Rhizoma Rhei 12g, Folium meliae 12g, Coniogramme japonica (Thunb.) Diels 22g, Rhizoma Cimicifugae 12g, Fructus Evodiae 12g, Radix Bupleuri 22g, Radix Glehniae 2g, Fructus Choerospondiatis 12g, Rhizoma Alpiniae Officinarum 22g, mountain vitriol 22g, Myrrha 22g, Chrysosplenium grayanum Maxim. 32g, Folium Eriobotryae 32g, Flos Ginseng 32g, Massa Medicata Fermentata 32g.

Preparation method is identical with embodiment 1.

Embodiment 3, prescription:

Corn 35g, Testa Tritici 35g, Oryza glutinosa 35g, Radix Ginseng 15g, Cortex Lycii 15g, Folium Artemisiae Argyi 15g, Radix Saposhnikoviae 25g, Herba Agrimoniae 5g, Semen Lactucae sativae 5g, Radix Et Rhizoma Rhei 15g, Folium meliae 15g, Coniogramme japonica (Thunb.) Diels 25g, Rhizoma Cimicifugae 15g, Fructus Evodiae 15g, Radix Bupleuri 25g, Radix Glehniae 5g, Fructus Choerospondiatis 15g, Rhizoma Alpiniae Officinarum 25g, mountain vitriol 25g, Myrrha 25g, Chrysosplenium grayanum Maxim. 35g, Folium Eriobotryae 35g, Flos Ginseng 35g, Massa Medicata Fermentata 35g.

Preparation method is identical with embodiment 1.

Embodiment 4, prescription:

Corn 38g, Testa Tritici 38g, Oryza glutinosa 38g, Radix Ginseng 18g, Cortex Lycii 18g, Folium Artemisiae Argyi 18g, Radix Saposhnikoviae 28g, Herba Agrimoniae 8g, Semen Lactucae sativae 8g, Radix Et Rhizoma Rhei 18g, Folium meliae 18g, Coniogramme japonica (Thunb.) Diels 28g, Rhizoma Cimicifugae 18g, Fructus Evodiae 18g, Radix Bupleuri 28g, Radix Glehniae 8g, Fructus Choerospondiatis 18g, Rhizoma Alpiniae Officinarum 28g, mountain vitriol 28g, Myrrha 28g, Chrysosplenium grayanum Maxim. 38g, Folium Eriobotryae 38g, Flos Ginseng 38g, Massa Medicata Fermentata 38g.

Preparation method is identical with embodiment 1.

Embodiment 5, prescription:

Corn 40g, Testa Tritici 40g, Oryza glutinosa 40g, Radix Ginseng 20g, Cortex Lycii 20g, Folium Artemisiae Argyi 20g, Radix Saposhnikoviae 30g, Herba Agrimoniae 10g, Semen Lactucae sativae 10g, Radix Et Rhizoma Rhei 20g, Folium meliae 20g, Coniogramme japonica (Thunb.) Diels 30g, Rhizoma Cimicifugae 20g, Fructus Evodiae 20g, Radix Bupleuri 30g, Radix Glehniae 10g, Fructus Choerospondiatis 20g, Rhizoma Alpiniae Officinarum 30g, mountain vitriol 30g, Myrrha 30g, Chrysosplenium grayanum Maxim. 40g, Folium Eriobotryae 40g, Flos Ginseng 40g, Massa Medicata Fermentata 40g;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations after mix homogeneously, the drying, oral administration, during the control once a day, every day three times during the treatment, each 20-30g.

Chinese medicine composition of the present invention is to the acute toxicity test of mice

Experimental animal

The healthy KM mice of SPF level, 30, male and female half and half, body weight 20-25g; Available from the Sichuan Provincial Academy of Traditional Chinese Medicine Experimental Animal Center

Test method

After 3 days adaptabilities are raised, be divided into 5 groups (male and female half and half) at random, every group each 10; Matched group, 4 various dose groups (only be respectively 76mg/, 152.1mg/, 219.9mg/, 357.6mg/ only).Mice free choice feeding, drinking-water in the feeding process, change water every day, the next day change bedding and padding.The whole test phase is 7 days.

6. testing index and method

(1) clinicing symptom observation: every day the viewing test Mus the mental status, diet situation, record morbidity every day death condition.

(2) pathological observation: cut open inspection for dead Mus and observe the internal organs variation.

(3) growth indexes is observed: the test Mus is carried out routine weighing; Off-test, slaughter that Mus weighs in, the heavy organ index of internal organs measures: cut open the inspection kunming mice, dirty, the spleen of coring, liver, kidney, testis, ovary are weighed, and calculate organ index according to following formula: organ index=internal organs weight/body weight * 100.

(4) liver function changes observation: after the off-test, slaughter Mus, take blood separation serum, measure AST, ALT.

7. date processing: above The data SPSS11.0 carries out analytic statistics.

Clinicing symptom observation

Matched group and test group Mus, the mental status and diet are desired, respond is not seen significantly unusual to external world.Each organizes Mus morbidity and death condition such as following table 1.

Table 1

Pathological observation: matched group and test group, cut open after Mus is slaughtered to examine to observe and do not see the tangible pathological change of observation internal organs.

Growth indexes is observed: off-test, slaughter that Mus weighs in, the internal organs weight analysis sees Table 2.

Table 2

Liver function changes to be observed

After the off-test, slaughter Mus, take blood separation serum, measure AST, ALT and see Table 3.The result shows and respectively organizes data and normal healthy controls group to compare difference not remarkable, all is in normal range.

Table 3

Clinical experiment 1

With 360 healthy cattle (male and female half and half, body weight is between 150kg～200kg) be divided into three groups at random, group I is the counteracting toxic substances matched group, group II is the test group of taking the Chinese medicine composition 1 back counteracting toxic substances that embodiment 3 makes, group III is the test group of taking the Chinese medicine composition 2 back counteracting toxic substances that embodiment 4 makes, group I only feeds with the normal feedstuff Semen Tritici aestivi, and every day, Chinese medicine composition that every cattle is joined was suitable with 1.5 gram raw material of Chinese medicine doses; Each organizes cattle free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease cattle symptom every day when 9:00 and 16:00, dead cattle is only weighed, the anatomic observation pathological change, and perform itemized record, dead cattle only weighed, dissects in ten days to having tested, and record pathological changes situation, after test is finished, test mortality rate, effective percentage are carried out data statistics, and concrete outcome sees Table 4.

Table 4

In this experimentation, allly at duration of test symptom of the present invention and dead appears, the ill apparition person of necropsy, be judged to infect dead.

Effectively after medication, not ill cattle only is effectively, and it is effective percentage that every group of healthy cattle number accounts for the percentage rate of testing the cattle number.

From table 4, we adopt Chinese medicine composition of the present invention that cattle sudden death disease is had significant preventive effect as can be seen.

Clinical experiment 2

With 480 health pig (male and female half and half, body weight is between 100kg～200kg) be divided into four groups at random, group I is the counteracting toxic substances matched group, group II is the test group of taking the Chinese medicine composition 1 back counteracting toxic substances that embodiment 1 makes, group III is the test group of taking the Chinese medicine composition 2 back counteracting toxic substances that embodiment 2 makes, group IIII is the test group of taking the Chinese medicine composition 2 back counteracting toxic substances that embodiment 2 makes, and group I only feeds with the normal feedstuff Semen Tritici aestivi, and every day, Chinese medicine composition that every pig is joined was with 1.5 to restrain the raw material of Chinese medicine doses suitable; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, observe disease pig symptom every day when 9:00 and 16:00, dead pig is only weighed, the anatomic observation pathological change, and perform itemized record, dead pig only weighed, dissects in ten days to having tested, and record pathological changes situation, after test is finished, test mortality rate, effective percentage are carried out data statistics, and concrete outcome sees Table 5.

Table 5

In this experimentation, allly at duration of test symptom of the present invention and dead appears, the ill apparition person of necropsy, be judged to infect dead.

Effectively after medication, not ill pig only is effectively, and the percentage rate that every group of health pig number accounts for the test pig number is effective percentage.

From table 5, we adopt Chinese medicine composition of the present invention that pig sudden death disease is had significant preventive effect as can be seen.

The invention has the beneficial effects as follows:

The all medicines of the present invention are united utilization, benefiting QI for strengthening the superficies, strengthening the spleen and stomach, oral mucosa, hoof and the prevention of skin of breast generation vesicle rash and treatment there is positive effect, have no side effect, have no drug resistance, economical and effective is convenient is worth application, preparation of the present invention can be by stomach acids destroy, directly arrive intestinal and slowly discharge and be absorbed and act on the normal immunologic function of conditioning cattle body, effect is obvious.

Claims (3)

1. a Chinese medicine for the treatment of livestock foot-and-mouth disease is characterized in that, is made up of the raw material of following weight portion:

Corn 30-40 part, Testa Tritici 30-40 part, Oryza glutinosa 30-40 part, Radix Ginseng 10-20 part, Cortex Lycii 10-20 part, Folium Artemisiae Argyi 10-20 part, Radix Saposhnikoviae 20-30 part, Herba Agrimoniae 1-10 part, Semen Lactucae sativae 1-10 part, Radix Et Rhizoma Rhei 10-20 part, Folium meliae 10-20 part, Coniogramme japonica (Thunb.) Diels 20-30 part, Rhizoma Cimicifugae 10-20 part, Fructus Evodiae 10-20 part, Radix Bupleuri 20-30 part, Radix Glehniae 1-10 part, Fructus Choerospondiatis 10-20 part, Rhizoma Alpiniae Officinarum 20-30 part, mountain vitriol 20-30 part, Myrrha 20-30 part, Chrysosplenium grayanum Maxim. 30-40 part, Folium Eriobotryae 30-40 part, Flos Ginseng 30-40 part, Massa Medicata Fermentata 30-40 part;

Preparation method:

By formula proportion with above composition extract routinely, separate, dry, pulverize, composite in proportion, can be made into tablet, capsule, oral formulations after mix homogeneously, the drying, oral administration, during the control once a day, every day three times during the treatment, each 20-30g.

2. a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease according to claim 1 is characterized in that, is made up of the raw material of following weight portion:

Corn 32-38 part, Testa Tritici 32-38 part, Oryza glutinosa 32-38 part, Radix Ginseng 12-18 part, Cortex Lycii 12-18 part, Folium Artemisiae Argyi 12-18 part, Radix Saposhnikoviae 22-28 part, Herba Agrimoniae 2-8 part, Semen Lactucae sativae 2-8 part, Radix Et Rhizoma Rhei 12-18 part, Folium meliae 12-18 part, Coniogramme japonica (Thunb.) Diels 22-28 part, Rhizoma Cimicifugae 12-18 part, Fructus Evodiae 12-18 part, Radix Bupleuri 22-28 part, Radix Glehniae 2-8 part, Fructus Choerospondiatis 12-18 part, Rhizoma Alpiniae Officinarum 22-28 part, mountain vitriol 22-28 part, Myrrha 22-28 part, Chrysosplenium grayanum Maxim. 32-38 part, Folium Eriobotryae 32-38 part, Flos Ginseng 32-38 part, Massa Medicata Fermentata 32-38 part.

3. a kind of Chinese medicine for the treatment of livestock foot-and-mouth disease according to claim 1 is characterized in that, is made up of the raw material of following weight portion:

35 parts of corns, 35 parts of Testa Triticis, 35 parts in Oryza glutinosa, 15 parts of Radix Ginsengs, 15 parts of Cortex Lycii, 15 parts of Folium Artemisiae Argyis, 25 parts of Radix Saposhnikoviaes, 5 parts of Herba Agrimoniaes, 5 parts of Semen Lactucae sativae, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Folium meliae, 25 parts of Coniogramme japonica (Thunb.) Diels, 15 parts of Rhizoma Cimicifugaes, 15 parts of Fructus Evodiaes, 25 parts of Radix Bupleuri, 5 parts of Radix Glehniaes, 15 parts of Fructus Choerospondiatis, 25 parts of Rhizoma Alpiniae Officinarums, 25 parts of mountain vitriol, 25 parts of Myrrhas, 35 parts of Chrysosplenium grayanum Maxim., 35 parts of Folium Eriobotryaes, 35 parts of Flos Ginseng, 35 parts of Massa Medicata Fermentata.