CN103239673B - Traditional Chinese medicine composition for preventing and curing sudden death syndrome of cow - Google Patents

Abstract

The invention aims to provide a traditional Chinese medicine composition for preventing and curing sudden death syndrome of a cow, which has the advantages of obvious curing effect, no toxic and side effects, no medicine resistance, economy, effectiveness and convenience, and is characterized in that the composition consists of the following raw materials in parts by weight: 20-30 parts of ramulus euonyrni, 20-30 parts of toosendan leaf, 20-30 parts of radix stemonae, 20-30 parts of hairyvein agrimony, 20-30 parts of lotus stamen, 10-20 parts of dracontomelon duperreanum, 10-20 parts of nutmeg, 10-20 parts of evodia, 10-20 parts of fructus amomi, 10-20 parts of lesser galangal rhizome, 10-20 parts of agastache rugosus, 10-20 parts of fluorite, 1-10 parts of radix astragali, 1-10 parts of lindera aggregata, 1-10 parts of semen cuscutae, 1-10 parts of folium eriobotryae, 1-10 parts of fennel, 1-10 parts of honey, 30-40 parts of ginseng flower, 30-40 parts of scandent schefflera stem and leaf, 30-40 parts of massa medicata fermentata fujianensis, 30-40 parts of peony flower and 30-40 parts of corn.

Description

A kind of Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome.

Background technology

Cattle Sudden Death Syndrome is a kind of clinical symptoms agnogenio, sudden death.Because its cause of disease not yet is finalized, with clinical sudden onset, acute death, thus fix tentatively as " Sudden Death Syndrome ", larger to cattle-raising harm.

About the cause of disease of primary disease, Recent study report is more, there is no final conclusion, can be summarized as follows:

1. cattle is eaten forage grass or the feedstuff that Fluoroacetic acid amide pollutes by mistake.

Cattle infected A type Wei Shi shuttle Seedling cause send out a primary disease, or pathogenic escherichia coli mixed infection cause send out.

3. Niu Yanchong lacks the acute death that selenium causes.Symptom cattle is searching for food, after usage, food soon or when rest, Mortality suddenly, and primary disease feature is that morbidity is anxious, dead fast.Cattle morbidity is anxious, be mostly again and again toot cry, terrified, mouthful tell white or kermesinus foam, after neck and breast side contrary vertical by hair, omoplate and hindlimb muscle tremble, body temperature is normal or on the low side, fall down to the ground suddenly, extremity paddling, death in 1 hour ~ 2 hours.

Prevention should adopt comprehensive preventive measure to primary disease.To the normal area of sending out of fluoroacetamide poisoning, should strengthen publicity, prevent raticide pollution forage grass or feedstuff.For scarce selenium area, should regularly give cattle supplementary feeding containing selenium vitamin E.To infecting as main area taking A type clostridieum welchii, can select multi-joint clostridieum welchii Seedling, give regularly immunity of Niu Jinhang.

Treatment is anxious, dead fast because of cattle Sudden Death Syndrome morbidity, often has little time diagnosis and treatment, or does not wait veterinary personnel to show up, and sick cattle is death.Making a definite diagnosis of primary disease is main by after death checking.Can adopt gastric content and carry out toxicological analysis, also can gather intestinal tube and carry out bacteriology checking etc.

In recent years, in Hainan of China, Anhui, Shandong, Henan, Liaoning, Jilin etc. economize widely popularly, cause large quantities of death, mortality rate is high.According to us, to 1003 routine analysiss of cases, mortality rate reaches 99%, and therefore, primary disease is formulated to corresponding anti-measure processed has as early as possible become the task of top priority.

Summary of the invention

The object of this invention is to provide a kind of therapeutic effect significantly, have no side effect, have no drug resistance, economical and effective a kind of Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome easily.

A Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome, is characterized in that, is made up of the raw material of following weight portion:

Ramulus Euonymi 20-30 part, Folium meliae 20-30 part, Radix Stemonae 20-30 part, Radix Agrimoniae 20-30 part, Stamen Nelumbinis 20-30 part, Fructus Dracontomeli Duperreani 10-20 part, Semen Myristicae 10-20 part, Fructus Evodiae 10-20 part, Fructus Amomi 10-20 part, Rhizoma Alpiniae Officinarum 10-20 part, Herba Pogostemonis 10-20 part, Fluoritum 10-20 part, Radix Astragali 1-10 part, Radix Linderae 1-10 part, Semen Cuscutae 1-10 part, Folium Eriobotryae 1-10 part, Fructus Foeniculi 1-10 part, Mel 1-10 part, Flos Ginseng 30-40 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30-40 part, Massa Medicata Fermentata 30-40 part, Flos Moutan 30-40 part, Semen Maydis 30-40 part,

Preparation method:

By formula proportion, above composition is extracted routinely, separates, is dried, is pulverized, composite in proportion, mix homogeneously, can be made into tablet, capsule, oral formulations after dry, oral administration, during control once a day, every day three times during treatment, each 3.6g.

A Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome, is characterized in that, is made up of the raw material of following weight portion:

Ramulus Euonymi 22-28 part, Folium meliae 22-28 part, Radix Stemonae 22-28 part, Radix Agrimoniae 22-28 part, Stamen Nelumbinis 22-28 part, Fructus Dracontomeli Duperreani 12-18 part, Semen Myristicae 12-18 part, Fructus Evodiae 12-18 part, Fructus Amomi 12-18 part, Rhizoma Alpiniae Officinarum 12-18 part, Herba Pogostemonis 12-18 part, Fluoritum 12-18 part, Radix Astragali 2-8 part, Radix Linderae 2-8 part, Semen Cuscutae 2-8 part, Folium Eriobotryae 2-8 part, Fructus Foeniculi 2-8 part, Mel 2-8 part, Flos Ginseng 32-38 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 32-38 part, Massa Medicata Fermentata 32-38 part, Flos Moutan 32-38 part, Semen Maydis 32-38 part.

The first step, is respectively charged into medicine in multi-function extractor, adds alcohol heating reflux to extract, merge extractive liquid,, centrifugal, filter, obtain filtrate, concentrating under reduced pressure reclaims ethanol, obtain extractum, by extractum stored refrigerated, enter subsequently in spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 object powder;

Second step, drops into above-mentioned powder in blender and is stirred to evenly under normal temperature and pressure conditions, obtains described Chinese medicine composition.

A Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome, is characterized in that, is made up of the raw material of following weight portion:

25 parts of Ramulus Euonymis, 25 parts of Folium meliae, 25 parts of the Radixs Stemonae, 25 parts of Radix Agrimoniaes, 25 parts of Stamen Nelumbiniss, 15 parts of Fructus Dracontomeli Duperreani, 15 parts of Semen Myristicaes, 15 parts of Fructus Evodiaes, 15 parts of Fructus Amomis, 15 parts of Rhizoma Alpiniae Officinarums, 15 parts of Herba Pogostemoniss, 15 parts of Fluoritum, 5 parts of the Radixs Astragali, 5 parts of the Radixs Linderae, 5 parts of Semen Cuscutae, 5 parts of Folium Eriobotryaes, 5 parts, Fructus Foeniculi, 5 parts of Mel, 35 parts of Flos Ginseng, 35 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 35 parts of Massa Medicata Fermentata, 35 parts of Flos Moutaies, 35 parts of Semen Maydiss.

the present invention relates to pharmacology and the property of medicine of Chinese medicine:

Ramulus Euonymi:

Winged euonymus, is named again that Ramulus Euonymi, terrible arrow, June are insulted, four sides cutting edge of a knife or a sword, castor dustpan bavin, four rib trees, Gallus jabouillei strip, halberd, JIANZHONGXIAO, anaesthetic on four sides.For branch or the aliform appurtenance of the tool aliform thing of Celastraceae plant winged euonymus.Can adopt the whole year, extracts after branch, removes twig and leaf, dries.Or collect its aliform thing, dry.There is removing blood stasis to stimulate the menstrual flow; Removing toxic substances and promoting subsidence of swelling; Effect of parasite killing.

[nature and flavor] hardship; Pungent; Cold.

1. " herbal classic ": bitter in the mouth, cold.

2. " WU Pu Bencao ": hardship, nontoxic.

3. " property of medicine opinion ": slightly poisonous.

4. " Japan hanako materia medica ": sweet-puckery flavor.

5. " detailed outline ": sour-puckery flavor.

[return through]: Liver Channel.

1. " book on Chinese herbal medicine brief points ": enter meridian of Foot-JUE YIN.

[effect and effect] removing blood stasis stimulates the menstrual flow; Removing toxic substances and promoting subsidence of swelling; Parasite killing.Primary symptom abdominal mass caking; Trusted subordinate's pain; Amenorrhea; Dysmenorrhea; Metrorrhagia and metrostaxis; The stagnant stomachache of the stasis of blood in puerperal; Retention of lochia; Hernia; Severe and migratory arthralgia arthralgia pain; Skin ulcer is swollen; Traumatic pain; Abdominal pain due to worm stagnation; Burn and scald; Venom.

1. " herbal classic ": main woman's metrorrhagia hematochezia, abdominal distention sweating.

2. not " not Lu ": main attacked by pestiferous factors stomachache, remove tapeworm, the skin pathogenic wind toxic that disappears is swollen, makes in the moon and separating.

3. " property of medicine opinion ": broken old blood, tire falls.Main attacked by pestiferous factors waist stomachache.

4. Tang Materia Medica: treat married woman's vim and vigour.

5. " Japan hanako materia medica ": logical menstruation, broken crux, hemostasis is collapsed, leukorrhagia, kills alvus worm, and puerperal, blood twisted belly pain.

6. " the real figure of general name examines ": control toxic swelling.

[clinical practice] promoting the circulation of blood is stimulated the menstrual flow, eliminating stasis to stop pain.For menoxenia, puerperal abdominalgia with blood stasis, traumatic injury swells and ache.

Folium meliae:

[meridian distribution of property and flavor] " Guangdong Chinese medicine " II: " hardship, cold, slightly poisonous." liver, lung, large intestine three warps.

[function] pain relieving, parasite killing.Control hernia, ascarid, treating swelling and pain by traumatic injury, furuncle, skin eczema.

Fructus Dracontomeli Duperreani:

[meridian distribution of property and flavor] sweet in the mouth, acid, cool in nature.

(1) " wide will ": " sweet in the mouth, property is flat, nontoxic." (drawing from " detailed outline is picked up any lost article from the road ")

(2) " detailed outline ": " sweet acid.”

(3) " it is former that book on Chinese herbal medicine is asked ": " acid, cold, nontoxic.”

(4) " south of the Five Ridges gather medicinal herbs record ": " property is flat, sweet in the mouth, acid.”

(5) " national Chinese herbal medicine compilation ": " acid, cool.”

[effect] stomach invigorating; Promote the production of body fluid; Relieving alcoholic intoxication; Removing toxic substances.Cure mainly inappetence; Calentura is thirsty; Drunk; Laryngopharynx swelling and pain; Pathogenic wind-toxic sore is itched.

[each discussion]

(1) " wide will ": " relieving alcoholic intoxication removing toxic substances.Control phoenix poison work people, pimple all over becomes skin ulcer, or pain or itch." (drawing from " detailed outline is picked up any lost article from the road ")

(2) " it is former that book on Chinese herbal medicine is asked ": " promote the production of body fluid, relieving alcoholic intoxication, is amusing, and anemia of pregnant woman suffers from abdominal pain and should eat.”

(3) " south of the Five Ridges gather medicinal herbs record ": " go laryngalgia, lose rotten meat.”

(4) " national Chinese herbal medicine compilation ": " strengthening the spleen to promote digestion, promoting the production of body fluid to quench thirst." " cure mainly dyspepsia, inappetence, calentura is thirsty.”

The Radix Stemonae:

[meridian distribution of property and flavor] is sweet, bitter, tepor.Return lung meridian.

The cough-relieving of [function cures mainly] nourishing the lung to keep the adverse QI downward, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.

Radix Agrimoniae:

[nature and flavor] nature and flavor hardship, puckery, temperature.

[function cures mainly] has hemostasis, and heart tonifying is strong, dysentery relieving and antiinflammation.Zhi Tuoli is tired, menoxenia, red leucorrhea, cold syndrome of the stomach stomachache, the dysentery of collapsing, spit blood, spitting of blood, hemorrhoidal hamorrhage, hematuria, metrorrhagia, the diseases such as duodenal hemorrhage, 1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache of face, with the passing of time red white dysentery.2. " BAICAO mirror ": the therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Fall and flutter haematemesis, metrorrhagia, dysentery, discharging fresh blood stool.3. " south of the Five Ridges gather medicinal herbs record " control married woman's menstruation or before or after, lumbago, heating sometimes.

Stamen Nelumbinis:

[nature and flavor] are sweet, puckery, flat.　　

[return through] GUIXIN, kidney channel.　　

[function cures mainly] reinforcing the kindey to control nocturnal emission.For emission and spermatorrhea, leukorrhagia, frequent micturition.

Semen Myristicae: warm in nature, acrid in the mouth, function warming the spleen stomach, circulation of qi promoting, helps digestion, Gu intestinal is applicable to the abdominal distention that Deficiency and coldness of spleen and stomach causes, dyspepsia does not disappear, lack of appetite vomiting, the disease of diarrhea due to deficiency cold-dysentery.

Fructus Evodiae:

[meridian distribution of property and flavor] is warm in nature, acrid in the mouth, hardship,

[function cures mainly] warming middle-JIAO to relieve pain, the dry temperature of regulating the flow of vital energy, is applicable to abdominal distention, vomiting and diarrhoea, singultus acid regurgitation, headache, colic, menstrual pain.

Fructus Amomi:

[nature and flavor] are warm in nature, acrid in the mouth,

During [function] circulation of qi promoting is adjusted, stomach function regulating, is amusing, and is applicable to breast gastral cavity painful abdominal mass vexed, and abdominal distention is eaten less, and the stomachache causing due to Deficiency and coldness of spleen and stomach is had loose bowels etc.

Rhizoma Alpiniae Officinarum:

[meridian distribution of property and flavor] is pungent, heat.Return spleen, stomach warp.

[function cures mainly] warming stomach for dispelling cold, pain relieving helps digestion.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.

Herba Pogostemonis: pungent, tepor.Return spleen, stomach, lung meridian.Function cures mainly: eliminating turbid pathogen with aromatics, appetizing preventing or arresting vomiting, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, the vomiting of gastral cavity painful abdominal mass, heat-damp in summer asthenia, uncomfortable in chest not easypro, cold-damp is closed summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache." kind reason Central Region turbid damp sputum, is the fast stomach of being amusing, and vibrates clear positive quality goods for Herba Pogostemonis, delicate fragrance tepor." not Lu " controls the swollen person of edema due to wind pathogen poison, dispels turbid damp, and self energy clear the course also.1. anti-leptospira effect 3. effects of antivirus action 4. to digestive system of antifungic action 2..

Fluoritum:

[meridian distribution of property and flavor] is sweet, temperature.Enter the heart, Liver Channel.

[function] relieving palpitation, calms the nerves, lowering the adverse flow of QI, warm uterus.Control asthenia palpitation with fear, cough with dyspnea, women's sea of blood deficiency and coldness is infertile.

The Radix Astragali has another name called Radix Astragali:

[meridian distribution of property and flavor] is sweet, temperature.Return lung, spleen channel.

[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

The Radix Linderae:

[nature and flavor] acrid in the mouth, warm in nature. enter spleen, lung, kidney, urinary bladder channel.

[function cures mainly] is pleasant, dissipating depression of QI, cold expelling, pain relieving. cure mainly: QI rising in reverse order chest and abdomen swelling and pain, dyspepsia do not disappear, food is told in regurgitation, colic of cold type, beriberi, frequent micturition.

Semen Cuscutae:

[nature and flavor] Gan Xinping, enters liver, kidney channel.

[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.For caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, the diseases such as frequent fetal movement.

Folium Eriobotryae:

[meridian distribution of property and flavor] hardship, is slightly cold.Attach to the lung and stomach meridians.

[function cures mainly] clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.

Fructus Foeniculi:

[nature and flavor] are warm in nature, acrid in the mouth; Return liver,kidney,spleen, stomach warp.

[function cures mainly] warming YANG to expel cold, regulating QI to relieve pain.For colic of cold type stomachache, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.

Mel:

[nature and flavor] nature and flavor are sweet;

[function] antibacterial antisepsis, has its antibacterial action to pathogenic bacterium such as escherichia coli, hemophilus influenza, streptococcus.

Flos Ginseng:

[nature and flavor]: bitterness Hui Tian, has the pungent sweet taste of Radix Ginseng.

[function]: supplement human body vigour, regain one's strength, strengthen body immunity.

Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae):

[meridian distribution of property and flavor] hardship, temperature; Enter lung, kidney,liver,spleen four warps;

[effect] relaxing muscles and tendons and activating QI and blood in the collateral, circulation of qi promoting damp eliminating, cold expelling dispels the wind, eliminating dampness to stop diarrhea.Cure mainly: for traumatic injury, fracture pain person, the arthralgia aggravated by cold of cold and damp stagnation, affection of exogenous wind-cold, heating fear of cold, head-body-pain.For distension and fullness in the abdomen, malaise, anorexia, poor appetite, dysentery person.

Massa Medicata Fermentata:

[nature and flavor] hardship, temperature; 1. the property of medicine is examined: micro-bitter fragrant sweet; 2. detailed outline is picked up any lost article from the road: sweet light, and delicate fragrance.

[function] removing dampness by means of aromatics, dispelling wind to relieve the exterior syndrome, digesting and appetizing.For Common Cold, summertime heatstroke, the heating of being afraid of cold, headache general pain, vomiting and diarrhoea, dyspepsia, abdominal distention uncomfortable in chest.

Flos Moutan:

Paeonia suffruticosa not only has ornamental value, but also has very high medical value.The root of Paeonia suffruticosa is processed into " Cortex Moutan ", is famous and precious Chinese herbal medicine.Its cold nature, acrid in the mouth, nontoxic, enter the heart, liver, kidney three warps, there is dissipating blood stasis blood, purify the blood and blood, pain relieving, the effect of stimulating the menstrual flow, reduce blood pressure in addition, effect of anti-inflammation, clothes can be lengthened the life by beneficial body for a long time.The regulating liver-QI that nourishes blood, loose strongly fragrant blood stasis dispelling, is applicable to chloasma faciei, and skin aging is often drunk the QI and blood lung of living, and appearance is ruddy, improves menoxenia, dysmenorrhea, only sweating due to debility, night sweat.

semen Maydis:

[nature and flavor] sweet in the mouth, property are put down, nontoxic.

[effect] cures mainly dribbling urination and urinary stone, and hurt like hell is decocted it at soup and drunk continuously several times.

It is the class that nutritive value is the highest.Vitamin content is rice, Semen Tritici aestivi 5-10 times.Also containing various trace elements is that other rice can not be compared.Dietary fiber Semen Maydis contains abundant cellulose, not only can stimulate enterokinesia, prevents constipation, can also promote the metabolism of cholesterol, accelerates the discharge of enterogenous endotoxin.

Semen Maydis is all precious from head to foot:

Vitamin A and vitamin E Semen Maydis contain vitamin A and vitamin E and glutamic acid etc.Zoopery proves, these compositions have anti-aging effects.

The Semen Maydis oil that unsaturated fatty acid corn germ is squeezed out contains a large amount of unsaturated fatty acids, and wherein linoleic acid accounts for 60%, can remove cholesterol harmful in blood, atherosclerosis.The contained nutrient substance of corn germ point has the human body of enhancing metabolism, adjusts nervous function.

Someone investigated, and the women of work is engaged in agriculture taking Semen Maydis as staple food in Africa, and the probability that they suffer from intestinal cancer is very low, and visible Semen Maydis has protective effect on cancer risk.In addition, Semen Maydis is more than 5 times of Semen sojae atricolor containing the amount of carotene, and carcinogen is also had to inhibitory action.

Nutrient Semen Maydis contains lysine, trace element-selenium, has the effect of prophylaxis of tumours.

Vitamin B group Semen Maydis also contains abundant vitamin B group, nicotinic acid etc., and to neuroprotective conduction and gastrointestinal function, prevention foot disorder of QI, myocarditis, safeguard that skin fitness is effective.

Other Stigma Maydis have stronger diuresis function, and urinary system infection, edema are had to therapeutical effect, and all right clearing heat secreting bile calculus, is applicable to liver gallbladder damp-heat type cholelithiasis etc.

detailed description of the invention:

Embodiment 1, formula:

Ramulus Euonymi 20g, Folium meliae 20g, Radix Stemonae 20g, Radix Agrimoniae 20g, Stamen Nelumbinis 20g, Fructus Dracontomeli Duperreani 10g, Semen Myristicae 10g, Fructus Evodiae 10g, Fructus Amomi 10g, Rhizoma Alpiniae Officinarum 10g, Herba Pogostemonis 10g, Fluoritum 10g, Radix Astragali 1g, Radix Linderae 1g, Semen Cuscutae 1g, Folium Eriobotryae 1g, Fructus Foeniculi 1g, Mel 1g, Flos Ginseng 30g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30g, Massa Medicata Fermentata 30g, Flos Moutan 30g, Semen Maydis 30g;

Preparation method:

By formula proportion, above composition is extracted routinely, separates, is dried, is pulverized, composite in proportion, mix homogeneously, can be made into tablet, capsule, oral formulations after dry, oral administration, during control once a day, every day three times during treatment, each 3.6g.

Embodiment 2, formula:

Ramulus Euonymi 22g, Folium meliae 22g, Radix Stemonae 22g, Radix Agrimoniae 22g, Stamen Nelumbinis 22g, Fructus Dracontomeli Duperreani 12g, Semen Myristicae 12g, Fructus Evodiae 12g, Fructus Amomi 12g, Rhizoma Alpiniae Officinarum 12g, Herba Pogostemonis 12g, Fluoritum 12g, Radix Astragali 2g, Radix Linderae 2g, Semen Cuscutae 2g, Folium Eriobotryae 2g, Fructus Foeniculi 2g, Mel 2g, Flos Ginseng 32g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 32g, Massa Medicata Fermentata 32g, Flos Moutan 32g, Semen Maydis 32g.

Preparation method:

The first step, is respectively charged into medicine in multi-function extractor, adds alcohol heating reflux to extract, merge extractive liquid,, centrifugal, filter, obtain filtrate, concentrating under reduced pressure reclaims ethanol, obtain extractum, by extractum stored refrigerated, enter subsequently in spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 object powder;

Second step, drops into above-mentioned powder in blender and is stirred to evenly under normal temperature and pressure conditions, obtains described Chinese medicine composition. [0077]embodiment 3, formula:

Ramulus Euonymi 25g, Folium meliae 25g, Radix Stemonae 25g, Radix Agrimoniae 25g, Stamen Nelumbinis 25g, Fructus Dracontomeli Duperreani 15g, Semen Myristicae 15g, Fructus Evodiae 15g, Fructus Amomi 15g, Rhizoma Alpiniae Officinarum 15g, Herba Pogostemonis 15g, Fluoritum 15g, Radix Astragali 5g, Radix Linderae 5g, Semen Cuscutae 5g, Folium Eriobotryae 5g, Fructus Foeniculi 5g, Mel 5g, Flos Ginseng 35g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 35g, Massa Medicata Fermentata 35g, Flos Moutan 35g, Semen Maydis 35g.

Preparation method is identical with embodiment 1.

Embodiment 4, formula:

Ramulus Euonymi 28g, Folium meliae 28g, Radix Stemonae 28g, Radix Agrimoniae 28g, Stamen Nelumbinis 28g, Fructus Dracontomeli Duperreani 18g, Semen Myristicae 18g, Fructus Evodiae 18g, Fructus Amomi 18g, Rhizoma Alpiniae Officinarum 18g, Herba Pogostemonis 18g, Fluoritum 18g, Radix Astragali 8g, Radix Linderae 8g, Semen Cuscutae 8g, Folium Eriobotryae 8g, Fructus Foeniculi 8g, Mel 8g, Flos Ginseng 38g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 38g, Massa Medicata Fermentata 38g, Flos Moutan 38g, Semen Maydis 38g.

Preparation method is identical with embodiment 1.

Embodiment 5, formula:

Ramulus Euonymi 30g, Folium meliae 30g, Radix Stemonae 30g, Radix Agrimoniae 30g, Stamen Nelumbinis 30g, Fructus Dracontomeli Duperreani 20g, Semen Myristicae 20g, Fructus Evodiae 20g, Fructus Amomi 20g, Rhizoma Alpiniae Officinarum 20g, Herba Pogostemonis 20g, Fluoritum 20g, Radix Astragali 10g, Radix Linderae 10g, Semen Cuscutae 10g, Folium Eriobotryae 10g, Fructus Foeniculi 10g, Mel 10g, Flos Ginseng 40g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40g, Massa Medicata Fermentata 40g, Flos Moutan 40g, Semen Maydis 40g;

Preparation method:

By formula proportion, above composition is extracted routinely, separates, is dried, is pulverized, composite in proportion, mix homogeneously, can be made into tablet, capsule, oral formulations after dry, oral administration, during control once a day, every day three times during treatment, each 3.6g.

the acute toxicity test of Chinese medicine composition of the present invention to mice

Experimental animal

The healthy KM mice of SPF level, 30, male and female half and half, body weight 20-25g; Purchased from Sichuan Provincial Academy of Traditional Chinese Medicine Experimental Animal Center

Test method

After the adaptabilities of 3 days are raised, be divided at random 5 groups (male and female half and half), every group each 10; Matched group, 4 various dose groups (be only respectively 76mg/, only, only, 357.6mg/ only for 219.9mg/ for 152.1mg/).Mice free choice feeding, drinking-water, in feeding process, change water every day, the next day change bedding and padding.Whole experimental period is 7 days.

6. testing index and method

(1) clinicing symptom observation: every day viewing test Mus the mental status, diet situation, every day entry Mortality situation.

(2) pathological observation: cut open inspection for dead Mus and observe internal organs variation.

(3) growth indexes is observed: test Mus is carried out to routine weighing; Off-test, slaughters that Mus weighs in, the heavy organ index of internal organs measures: cut open inspection kunming mice, dirty, the spleen of coring, liver, kidney, testis, ovary, weigh, and calculates according to the following formula organ index: organ index=internal organs weight/body weight × 100.

(4) liver function changes observation: after off-test, slaughter Mus, take blood separation serum, measure AST, ALT.

7. date processing: above data acquisition carries out analytic statistics with SPSS11.0.

Clinicing symptom observation

Matched group and test group Mus, the mental status and diet are wanted, respond has no significantly abnormal to external world.The morbidity of each group Mus and death condition are as following table 1.

Table 1

Pathological observation: matched group and test group, Mus is cutd open after slaughtering to examine to observe to have no and observes the obvious pathological change of internal organs.

Growth indexes is observed: off-test, slaughter that Mus weighs in, internal organs weight analysis is in table 2.

Table 2

Liver function changes to be observed

After off-test, slaughter Mus, take blood separation serum, measure AST, ALT in table 3.Result shows that each group of data difference compared with normal healthy controls group is not remarkable, all within normal range.

Table 3

Clinical experiment

By 360 healthy cattle (male and female half and half, body weight is between 150kg～200kg) be divided at random three groups, group I is counteracting toxic substances matched group, group II is the test group of taking the Chinese medicine composition 1 rear counteracting toxic substances that embodiment 3 makes, group III is the test group of taking the Chinese medicine composition 2 rear counteracting toxic substances that embodiment 4 makes, group I only feeds with normal feedstuff Semen Tritici aestivi, and every day, Chinese medicine composition that every cattle is joined was suitable with 1.5 grams of raw material of Chinese medicine doses; Each group cattle free choice feeding, drinking-water, Routine Management; Raise identical natural law, every day 9:00 and observe disease cattle symptom when 16:00, dead cattle is only weighed, anatomic observation pathological change, and perform itemized record, carry out not dead cattle only being weighed, being dissected in ten days to test, and recorded pathological changes situation, after having tested, test mortality rate, effective percentage are carried out to data statistics, and concrete outcome is in table 4.

Table 4

In this experimentation, allly there is symptom of the present invention dead at duration of test, the ill apparition person of necropsy, be judged to infect dead.

Effectively after medication, not ill cattle is only effectively, and the percentage rate that every group of healthy cattle number accounts for test cattle number is effective percentage.

From table 4, we can find out, adopt Chinese medicine composition of the present invention to have significant preventive effect to cattle Sudden Death Syndrome.

the invention has the beneficial effects as follows:

The all medicines of the present invention are combined utilization, benefiting QI for strengthening the superficies, strengthening the spleen and stomach, improve digestive system and normally work, evidence has positive effect for prevention and treatment cattle Sudden Death Syndrome, has no side effect, have no drug resistance, economical and effective is convenient is worth application, preparation of the present invention can be by stomach acids destroy, directly arrives intestinal and slowly discharges and be absorbed and act on the normal immunologic function of conditioning cattle body, successful.

Claims (5)

1. a Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome, is characterized in that, is made up of the raw material of following weight portion:

Ramulus Euonymi 20-30 part, Folium meliae 20-30 part, Radix Stemonae 20-30 part, Radix Agrimoniae 20-30 part, Stamen Nelumbinis 20-30 part, Fructus Dracontomeli Duperreani 10-20 part, Semen Myristicae 10-20 part, Fructus Evodiae 10-20 part, Fructus Amomi 10-20 part, Rhizoma Alpiniae Officinarum 10-20 part, Herba Pogostemonis 10-20 part, Fluoritum 10-20 part, Radix Astragali 1-10 part, Radix Linderae 1-10 part, Semen Cuscutae 1-10 part, Folium Eriobotryae 1-10 part, Fructus Foeniculi 1-10 part, Mel 1-10 part, Flos Ginseng 30-40 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30-40 part, Massa Medicata Fermentata 30-40 part, Flos Moutan 30-40 part, Semen Maydis 30-40 part.

2. a kind of Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome according to claim 1, is characterized in that, is made up of the raw material of following weight portion:

Ramulus Euonymi 22-28 part, Folium meliae 22-28 part, Radix Stemonae 22-28 part, Radix Agrimoniae 22-28 part, Stamen Nelumbinis 22-28 part, Fructus Dracontomeli Duperreani 12-18 part, Semen Myristicae 12-18 part, Fructus Evodiae 12-18 part, Fructus Amomi 12-18 part, Rhizoma Alpiniae Officinarum 12-18 part, Herba Pogostemonis 12-18 part, Fluoritum 12-18 part, Radix Astragali 2-8 part, Radix Linderae 2-8 part, Semen Cuscutae 2-8 part, Folium Eriobotryae 2-8 part, Fructus Foeniculi 2-8 part, Mel 2-8 part, Flos Ginseng 32-38 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 32-38 part, Massa Medicata Fermentata 32-38 part, Flos Moutan 32-38 part, Semen Maydis 32-38 part.

3. a kind of Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome according to claim 1, is characterized in that, is made up of the raw material of following weight portion:

25 parts of Ramulus Euonymis, 25 parts of Folium meliae, 25 parts of the Radixs Stemonae, 25 parts of Radix Agrimoniaes, 25 parts of Stamen Nelumbiniss, 15 parts of Fructus Dracontomeli Duperreani, 15 parts of Semen Myristicaes, 15 parts of Fructus Evodiaes, 15 parts of Fructus Amomis, 15 parts of Rhizoma Alpiniae Officinarums, 15 parts of Herba Pogostemoniss, 15 parts of Fluoritum, 5 parts of the Radixs Astragali, 5 parts of the Radixs Linderae, 5 parts of Semen Cuscutae, 5 parts of Folium Eriobotryaes, 5 parts, Fructus Foeniculi, 5 parts of Mel, 35 parts of Flos Ginseng, 35 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 35 parts of Massa Medicata Fermentata, 35 parts of Flos Moutaies, 35 parts of Semen Maydiss.

4. according to a kind of Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome described in claim 1-3 any one, it is characterized in that, preparation method is as follows: the first step, medicine is respectively charged in multi-function extractor, adds alcohol heating reflux to extract, merge extractive liquid,, centrifugal, filter, obtain filtrate, concentrating under reduced pressure reclaims ethanol, obtain extractum, by extractum stored refrigerated, enter subsequently in spray dryer dry, pulverize and sieve with pulverizer, obtaining granularity is 50～100 object powder;

Second step, drops into above-mentioned powder in blender and is stirred to evenly under normal temperature and pressure conditions, obtains described Chinese medicine composition.

5. according to a kind of Chinese medicine composition of preventing and treating cattle Sudden Death Syndrome described in claim 1-3 any one, it is characterized in that, preparation method is as follows:

By formula proportion, above composition is extracted routinely, separates, is dried, is pulverized, composite in proportion, mix homogeneously, can be made into tablet, capsule after dry, oral administration, during control once a day, every day three times during treatment, each 3.6g.