CN105994986A - Traditional Chinese medicine preparation for preventing and treating parasitic diseases of goats and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for preventing and treating parasitic diseases of goats and preparation method of traditional Chinese medicine preparation Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to a traditional Chinese medicine preparation for preventing and treating parasitic diseases of goats and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the raw materials of folium eucalypti, cortex meliae, cushaw seed and betel nut. The preparation method comprises the following steps: crushing dry folium eucalypti, cortex meliae and betel nut, adding 5-8 times of water by weight, decocting for 1-2 h, and filtering the medicinal liquor to obtain a filtrate; adding cushaw seed which is obtained via crushing and screening with a 50-mesh sieve into the filtrate, and uniformly stirring to obtain a medicinal liquor mixture; adding the medicinal liquor mixture into a feed, uniformly mixing, and feeding goats to eliminate parasites. The traditional Chinese medicine preparation has the characteristics that an obvious treatment effect is taken on diseases of such parasites as ascarids and tapeworms in the goat bodies, the goats are prevented from inflammation, and the food digesting ability and the immunity of the goats are improved.
Description
Technical field
The present invention relates to the field of a kind of Chinese medicine preparation preventing and treating parasitic disease, be specifically related to a kind of preventing and treating goat parasitic
Chinese medicine preparation of worm disease and preparation method thereof.
Background technology
In recent years, goat cultivation has become a kind of extensive welcome cultivation industry, brings wealth to raiser；So
How goat is carried out diseases prevention and treatment, be maximum focus；Parasitic disease is a kind of common disease in goat disease.
Parasitic disease many employings antibiotic drug to goat in the market, and goat is ruminant, the micro-life of cud
Goat nutrition thing is digested and assimilated to have by thing effect.The work that these medicines certainly will have suppression to rumen microorganism, kill
With, it is unfavorable for the fast-growth of goat；Increase aquaculture cost.
The Chinese herbal feed additive seminar that in June, 1999 holds in Beijing, participant expert unanimously think, researches and develops medium-height grass
Medicine feed additive has the most important academic significance and practical value.Test proves, application Chinese herbal medicine is possible not only to individual
Body is cured the disease, and can prevent and treat with colony.It is particularly suitable for the needs of large-scale breeding.Chinese herbal medicine is main in terms of prevention animal epidemic
It is by improving the resistance against diseases of animal body self and improve the realization of body non-specific immunity, the most directly acting on
In pathogenic microorganism.So, Chinese herbal medicine will not be developed immunity to drugs by pathogenic microorganism.It is natural materials because of Chinese herbal medicine again, keeps
The naturality of various compositions and biological activity, its composition and animal body are the most harmonious, are easily absorbed and utilize, do not absorbed
Also can excrete smoothly.Therefore, the problem that there is not drug residue.This complies fully with the nuisanceless animal husbandry of development, produces
The feed additive standard of safe animal products.
The defect that the present invention is directed to prior art is improved, and the present inventor is according to traditional Chinese medical science medicine principle with to goat habit
Long-term observation, develop a kind of Chinese medicine preparation preventing and treating goat parasitic disease；Effectively solve goat endoparasite disease
Problem.
Summary of the invention
It is an object of the invention to provide and a kind of prevent and treat the parasitic diseases such as ascarid parasitic in goat body, cestode, again can
Prevention goat inflammation, improves the food digestion ability of goat and the Chinese medicine preparation improving goat immune power and preparation method thereof.
The present invention is a kind of Chinese medicine preparation preventing and treating goat parasitic disease, it is characterised in that: its effective ingredient be by with
Lower weight portion raw material of Chinese medicine is made:
Eucalyptus leaves 10-15 part bark of Melia azedarach L. 10-15 part Semen Cucurbitae 15-20 part Semen Arecae 8-12 part.
Described eucalyptus leaves can be one or both in fast-growing Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Eucalypti Robustae.
Described Chinese medicine preparation preparation method is as follows:
(1), the eucalyptus leaves of dry product, bark of Melia azedarach L. and Semen Arecae are blended, add 5-8 times of water by weight, decoct 1-2 hour, filter medicine
Liquid, obtains filtrate；
(2), by gained filtrate adds the Semen Cucurbitae pulverizing 50 mesh sieves, stir, obtain medicine liquid mixture；
(3), medicine liquid mixture is added in feedstuff, mix homogeneously, the medicinal liquid mixing of 0.5-1 jin is added by every 100 jin of feedstuffs
Thing, feeds 3-5 days, can discharge parasite.
The Chinese medicine preparation of described preventing and treating goat parasitic disease is in preparation treatment ascarid, the application of cestode endo-medicine.
The present invention be a kind of its raw material of Chinese medicine preparation of goat parasitic disease of preventing and treating through modern science analysis, have dynamic
Multiple chemical composition needed for object, such as:
1, volatile oil, flavone, tannin, triterpenes etc..
2, Melia azedarach L. terpene ketone lactone (kulactone), Melia azedarach L. terpene alcoholic lactone (kulolactone), Cortex Meliae terpene ketone
(kulinone), Melia azedarach L. terpene acid methyl ester (methyl kulonate), Fructus Toosendan terpene ketone (melianone), Azadirachta Indica A. guest (nimbin)
And Azadirachta Indica A. aldehyde (ohchinal)；The sterols chemical combination such as Semen Brassicae Campestris steroid ketenes, stigmastene ketone, b-sitosterol-3-O-b-D-glycoside
Thing.
3, Cucurbitin (cucurbitine), fatty oil, protein, vitamin B1, C etc..
4, lauric acid, myristic acid, Palmic acid, stearic acid, capric acid, oleic acid, linoleic acid, dodecenoic acid and 14 carbon are dilute
Acid；Mannose, galactose, sucrose, γ-catechin, leucocyanidin (leuco-cyanidin), red pigment arecin (areca acid) and Saponin；Proline (proline), tryptophan (TCMLIByptophane), methionine (methionine), cruel
Propylhomoserin (tyrosine), arginine (arginine), phenylalanine (phenylalanine) etc..
The Chinese medicine preparation of above-mentioned preventing and treating goat parasitic disease its prepare raw material, can be from " Chinese Pharmacopoeia " and other Chinese medicine
Handbook is found its another name, latin name and the place of production, usage, treats the mechanism of disease in order to understand the present invention, existing to above-mentioned respectively
Effect and the pharmacological of the former medicine of taste are summarized as follows:
1, eucalyptus leaves, latin name:Eucalyptus, for the leaf of myrtle Eucalyptus globulus Labill.The whole year can adopt, and folding takes Lao Ye, dries in the shade
Or using fresh herb；That rubs micro-has fragrance, and taste is slightly bitter and cool.Eucalyptus leaves is the special food of koala, is often used to refine anthelmintic, deodorization
Agent.And eucalyptus globulus has disinfective action for air, therefore live in the environment of Eucalyptus, beneficially health.[nature and flavor are returned
Warp] acrid in the mouth；Bitter；Cold in nature；Return lung；Stomach；Spleen；Liver Channel.[function with cure mainly] 1), dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating, kill
Worm is antipruritic.Main flu, high dyspnea of heat type coughs, pertussis, abdominal distention, diarrhoea, dysentery, hook, filaricide, malaria, rheumatalgia, eczema,
Scabies, burn and scald, traumatic hemorrhage.2), effect that eucalyptus globulus quintessence oil is maximum in application is the most effective to various inflammation and fever.Right
In the sufferer having a high fever, eucalyptus globulus quintessence oil can produce the hypothermic effect of fall rapidly.Eucalyptus globulus quintessence oil is one of best antibacterial, has very
Strong sterilizing power, the most also has an effect reducing internal mucous viscosity, thus can be used for physical therapy pulmonary tuberculosis, bronchitis, white
Larynxs etc., can relax inflammation phenomenon and make mucosa comfortable.Eucalyptus globulus quintessence oil has spasmolytic, pain relieving, alleviation muscular soreness and rheumatalgia etc. to make
With, often make an addition to basis massage oil in by massage relax muscle rigidity ache wait discomfort.
2, bark of Melia azedarach L., latin name:Melia azedarach L., it is i.e. the bark of margosa, has the highest medicinal valency
Value, can treat numerous disease, and parasite killing etc. is used.Distribution north to Hebei, south to Guangxi, Yunnan, west to Sichuan and other places.[meridian distribution of property and flavor]
Bitter；Cold；Poisonous.[function with cure mainly] heat clearing and damp drying；Killing parasites for relieving itching；Promoting the circulation of QI to relieve pain；Tinea is treated in anthelmintic.For ascariasis, malnutrition due to parasitic infestation abdomen
Bitterly, scabies pruritus.Eczema pruritus；Skin ulcer tinea mange；Snake bite and insect sting；Trichomonal vaginitis；Hernia pain；Treating swelling and pain by traumatic injury.
3, Semen Cucurbitae, latin name:Cucurbita moschata (Duch. ex Lam.) Duch. ex Poiret, calabash
The seed of Lu Ke cucurbita plants Fructus Cucurbitae moschatae.Autumn, harvesting ripe fruit, took out seed, cleans and dries.Levigation is primary, with fresh person
Good.Demonstrate,prove for cestode.This product has the merit of parasite killing, and sweet putting down does not hinders healthy energy, is mainly used in killing and expelling tenia.With controlling taeniasis, often with
The same use of Semen Arecae, can heighten the effect of a treatment.[meridian distribution of property and flavor] is sweet, temperature；Enter kidney channel, Liver Channel.[function with cure mainly] anthelmintic, detumescence.For controlling
Cestode, ascarid, brothers' edema in puerperal, pertussis, hemorrhoid.[pharmacological action] Lumbricus laboratory method proves that Semen Cucurbitae ethanol extraction has
Anthelmintic action.Cat gavage of Semen Cucurbitae concentrate formulation 100-300mg/kg, has obvious anthelmintic to make cestode, bow ascarid etc.
With.40% pumpkin seed powder boils liquid and 30% Semen Benincasae extract has fiber crops to taeniasis bovis or the stage casing of taeniasis suis and back segment in vitro
Numbness effect, is allowed to thinning and broadens, nodal plate medial recess (stage casing nodal plate is especially apparent), to its head and immature proglottid then without this
Effect.Once dog and mice were fed, to dog encapsulation taeniasis, bean shape taeniasis and mice short putamina silk ribbon with the dl-Cucurbitin of synthesis
Worm is the most effective；Experiment in vitro proves, 1: 500 solution makes Taenia elliptica the most excited, even contracture, and has association with Arecoline hydrobromide
Same-action.
4, Semen Arecae, latin name:Areca catech, another name Bin Men, core frequency, core is bulky, miasma red, celestial of washing miasma red, spiral shell fruit, with coconut palm
Son belongs to Palmae aiphyllium together, and trunk can be grown to 20 meters." Semen Arecae " etymology is in Malay " pinang ".Semen Arecae originates in horse
Coming West Asia, torrid areas, East Africa and the Oceania such as Asia Sri Lanka, Thailand, India are contained in distributed areas.[meridian distribution of property and flavor] taste
Bitter；Pungent；Warm in nature.Return stomach；Large intestine channel.[function with cure mainly] anthelmintic；Removing food stagnancy；The therapeutic method to keep the adverse QI flowing downwards；Row water；Preventing the attack (or recurrence) of malaria.Malnutrition due to parasitic infestation；Dyspepsia；Gastral cavity abdominal distention
Bitterly；Weight after dysentery；Tinea pedis；Edema；Malaria.[pharmacological action] is to cestode, pinworm, anthelmintic, the effect of ascarid: experiment in vitro table
Bright, 30% Semen Arecae decoct 40 minutes can make dog dwarf tapeworm stiff or even dead.1-2% goes the Semen Arecae extract of tannic acid can make Carnis Sus domestica
Cestode, taeniasis bovis are flaccid paralysis with dwarf tapeworm, and cephalomere and immature proglottid are more sensitive than mature segment, its paralysis effect
Position may be at nervous system at muscle.But taeniasis bovis sensitivity is poor, it may be the bigger event of gravid proglottid.Semen Arecae
Decoct also has paralysis effect to Mus pinworm, and 25% concentration 45min can make Mus pinworm be inhibitory state, but after inserting in ringer solution
30 minutes, the Mus pinworm of 60% is had to reactivate.Semen Arecae 50% water-actone extraction thing has the strongest killing to ascaris alata larva of a tapeworm or the cercaria of a schistosome body
Activity, may occur in which burst effect, and the effect of Semen Arecae hot water extract is more weak.The straight chain fatty acid of Semen Arecae also has stronger killing
Ascaris alata larva of a tapeworm or the cercaria of a schistosome body activity, wherein the activity with lauric acid (dodecylic acid) is the strongest, and it is inactive that carbochain is shorter than 6 carbon persons, and carbochain number surpasses
After 13 time, activity declines rapidly.Experiment in vivo shows, Semen Arecae and Semen Cucurbitae are responsible for cestode paralysis, collaborative with the use of having
Effect.Take 48.5mg arecoline bismuth iodine compound to cat and can displace the band-shaped cestode of cat and japanese double cord tapeworm.Semen Arecae decoct can drive
Go out the short and small Hymenolepis of mice, also can displace pinworm.Arecoline hydrobromide 0.4mg/kg ig has 95% row's anthelmintic effect.[medicine record]
" book on Chinese herbal medicine is newly organized ": Semen Arecae, acrid in the mouth, hardship, temperature, fall, cloudy middle-jiao yang, function of the spleen and stomach is also, nontoxic.Enter spleen, stomach, large intestine, lung four warp.Disappear water paddy, expectorant
Addiction, the most pained, kill three worms, after controlling, weight such as god, falls under all QI exhaustion, and the most broken stagnant gas is descending.If take too much, counter rush down the most paramount it
Gas.The kind miasma that disappears, two people from Guangdong bite so far as begun.Ancients doubt its consume vital qi, advise people to adjust stomach, and guard against food Semen Arecae.This also has sees
Speech, but non-general survey is also.The ground of south of the Five Ridges malarial region, its snakeworm poisonous gas, borrow inflammation to steam gesture atmosphere, handle up in mountain top water small stream, and clouds and mists in the mountains
The gas of water miasma, closes and invades people, has immediately and full vexed dizzy person.Non-Semen Arecae mouth is bitten, the most fast solution., there is a poison in the road in the world,
A thing must be given birth to come to sb.'s rescue.The Semen Arecae sense world, to gas just, is i.e. born between two Guangdong, former so rescuing the people in two Guangdong also.
" treating different diseases with the same therapeutic principle " in Chinese veterinarian is exactly this reason, and this is confirmed by many tests.Therefore, raise with medical herbs
Feed additives, has universal preventive effect to goat disease, and Chinese herbal medicine has multiple nutritional components and biological activity, is promoting
Caprine growth, improves Goat Raising power aspect and has remarkable effect.
Compared with the prior art, its prominent substantive distinguishing features with significantly progress is the present invention:
1, the present invention using eucalyptus leaves, bark of Melia azedarach L., Semen Cucurbitae and Semen Arecae as parasitic ascarid, cestode etc. in preventing and treating goat body
The medicament of parasitic disease, deinsectization is effective, has no side effect, and safety is good, butchers rear Carnis Naemorhedi and meets the requirement of health food.
2, rumen microorganism will not be adversely affected by the Chinese herbal medicine additive of the present invention, and the physiology not affecting goat is special
Property, Chinese herbal medicine additive possesses the particular/special requirement required for cultivating as goat, and feed additive is fully achieved should have work
With.
Detailed description of the invention
Below in conjunction with embodiments of the invention, the present invention is described in more detail:
Embodiment one:
The Chinese medicine preparation its preparation method of preventing and treating goat parasitic disease is as follows:
(1), eucalyptus leaves 10 parts (every deal is 25g, the most identical), bark of Melia azedarach L. 10 parts and the Semen Arecae 8 parts of dry product are blended, press
Weight adds 5 times of water, decocts 1 hour, filtering liquid medicine, obtains filtrate；
(2), by gained filtrate adds the Semen Cucurbitae 15 parts pulverizing 50 mesh sieves, stir, obtain medicine liquid mixture；
(3), medicine liquid mixture is added in feedstuff, mix homogeneously, the medicine liquid mixture of 0.5 jin is added by every 100 jin of feedstuffs,
Feed 5 days, parasite can be discharged, can ascarid, cestode both parasites be laid simultaneously.
Embodiment two:
The Chinese medicine preparation its preparation method of preventing and treating goat parasitic disease is as follows:
(1), eucalyptus leaves 12 parts (every deal is 25g, the most identical), bark of Melia azedarach L. 12 parts and the Semen Arecae 10 parts of dry product are blended,
Add 7 times of water by weight, decoct 1 hour, filtering liquid medicine, obtain filtrate；
(2), by gained filtrate adds the Semen Cucurbitae 18 parts pulverizing 50 mesh sieves, stir, obtain medicine liquid mixture；
(3), medicine liquid mixture is added in feedstuff, mix homogeneously, the medicine liquid mixture of 0.8 jin is added by every 100 jin of feedstuffs,
Feed 4 days, parasite can be discharged, can ascarid, cestode both parasites be laid simultaneously.
Embodiment three:
The Chinese medicine preparation its preparation method of preventing and treating goat parasitic disease is as follows:
(1), eucalyptus leaves 12 parts (every deal is 25g, the most identical), bark of Melia azedarach L. 12 parts and the Semen Arecae 10 parts of dry product are blended,
Add 7 times of water by weight, decoct 1 hour, filtering liquid medicine, obtain filtrate；
(2), by gained filtrate adds the Semen Cucurbitae 18 parts pulverizing 50 mesh sieves, stir, obtain medicine liquid mixture；
(3), medicine liquid mixture is added in feedstuff, mix homogeneously, add the medicine liquid mixture of 1 jin by every 100 jin of feedstuffs, raise
Feed 3 days, parasite can be discharged, can ascarid, cestode both parasites be laid simultaneously.
Embodiment four:
The Chinese medicine preparation its preparation method of preventing and treating goat parasitic disease is as follows:
(1), eucalyptus leaves 15 parts (every deal is 25g, the most identical), bark of Melia azedarach L. 15 parts and the Semen Arecae 12 parts of dry product are blended,
Add 8 times of water by weight, decoct 1 hour, filtering liquid medicine, obtain filtrate；
(2), by gained filtrate adds the Semen Cucurbitae 20 parts pulverizing 50 mesh sieves, stir, obtain medicine liquid mixture；
(3), medicine liquid mixture is added in feedstuff, mix homogeneously, the medicine liquid mixture of 0.8 jin is added by every 100 jin of feedstuffs,
Feed 3 days, parasite can be discharged, can ascarid, cestode both parasites be laid simultaneously.
Clinical trial:
Clinical experiment animal selects Laboratory Diagnosed to be that parasitism has one or both ill goat in ascarid, cestode.By ill
Goat isolation is individually raised, and is randomly divided into 5 groups, often 20 goats of group, and 5 groups of feeding environments are identical, and experimental period carries out 5 altogether
My god；Blank group is left intact, and does not the most give Drug therapy.Computational methods: cure rate=healing number of animals/test is moved
Thing number × 100%.Following table is the result at the end of experiment.
Table is the embodiment applicable cases contrast that the present invention treats goat parasitic disease:
Safety testing:
Choose healthy goat 2 groups, often 10 goats of group, one group as blank, drug is not raised；Another group is in feedstuff
The Chinese medicine preparation adding the present invention carries out feeding, is 5 jin by every 100 jin of feedstuff additions, continuous feeding 5 days；During medication, strong
Kang Shanyang does not has any bad or Deviant Behavior performance, and compared with blank group, the individuality of goat is the strongst, and vigor is the strongest.
Claims (4)
1. the Chinese medicine preparation preventing and treating goat parasitic disease, it is characterised in that: its effective ingredient is by following weight portion
Medicine raw material is made:
Eucalyptus leaves 10-15 part bark of Melia azedarach L. 10-15 part Semen Cucurbitae 15-20 part Semen Arecae 8-12 part.
The Chinese medicine preparation of preventing and treating goat parasitic disease the most according to claim 1, it is characterised in that: described eucalyptus leaves
Can be one or both in fast-growing Folium eucalypti globueli (Eucalyptus globulus Labill.), Folium Eucalypti Robustae.
The Chinese medicine preparation of preventing and treating goat parasitic disease the most according to claim 1, it is characterised in that described Chinese medicine system
Agent preparation method is as follows:
(1), the eucalyptus leaves of dry product, bark of Melia azedarach L. and Semen Arecae are blended, add 5-8 times of water by weight, decoct 1-2 hour, filter medicine
Liquid, obtains filtrate；
(2), by gained filtrate adds the Semen Cucurbitae pulverizing 50 mesh sieves, stir, obtain medicine liquid mixture；
(3), medicine liquid mixture is added in feedstuff, mix homogeneously, the medicinal liquid mixing of 0.5-1 jin is added by every 100 jin of feedstuffs
Thing, feeds 3-5 days, can discharge parasite.
The Chinese medicine preparation of preventing and treating goat parasitic disease the most according to claim 1 takes orally preparation treatment ascarid, cestode
The application of medicine.
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Cited By (4)
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| CN106561563A (en) * | 2016-10-25 | 2017-04-19 | 界首市洪理养殖专业合作社 | Culture method for preventing 1-12 month Huaihai goat from ruminant tapeworm disease |
| CN108371244A (en) * | 2018-03-06 | 2018-08-07 | 张掖市金农源生物科技有限公司 | Feed addictive of parasitic disease and preparation method thereof is controlled in the drive of one sheep stud |
| CN108813173A (en) * | 2018-06-28 | 2018-11-16 | 大新县科学技术情报研究所 | Mutton sheep ecologic breeding feed and preparation method thereof |
| CN110279752A (en) * | 2019-06-06 | 2019-09-27 | 广西医科大学 | Fast-growing folium eucalypti extract and preparation method thereof and AntiHIV1 RT activity application |
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| CN110279752A (en) * | 2019-06-06 | 2019-09-27 | 广西医科大学 | Fast-growing folium eucalypti extract and preparation method thereof and AntiHIV1 RT activity application |
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