CN105079303A - Medicine for preventing and curing Chicken infectious anemia - Google Patents
Medicine for preventing and curing Chicken infectious anemia Download PDFInfo
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- CN105079303A CN105079303A CN201510622955.5A CN201510622955A CN105079303A CN 105079303 A CN105079303 A CN 105079303A CN 201510622955 A CN201510622955 A CN 201510622955A CN 105079303 A CN105079303 A CN 105079303A
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Abstract
The invention discloses a medicine for preventing and curing Chicken infectious anemia. The medicine comprises the following raw herbal materials: heartleaf houttuynia herb, herb of procumbent Indian mallow, radix sanguisorbae, herba chelidonii, Hainan rambutan, rhizome of canalike dona, leaf and twig of nakedflower beautyberry, fraxinus sieboldiana, all-grass of brunon veronicastrum, hemsleya macrosperma, Lobelia taliensis Diels, fruit of fiverleaf akebia, radix glycyrrhizae, orange leaves, herba cynomorii, radix morindae officinalis, Cerastiumrvense L., Parochetus communis, root of oval kumquat, ficus esquiroliana, ramulus cinnamomi, lotus leaf base, resina liquidamberis, sappanwood, flos campsis, radix polygalze, herba pyrolae, Limonium aureum (L.) Hill., Japanese metaplexis and root of shrubberry rhodiola. The medicine has the benefits that the medicine has the effects of diminishing inflammation, detoxifying, replenishing blood, activating blood circulation, and tonifying spleen to promote appetite, can prevent and cure Chicken infectious anemia, enhance chicken immunity, and is high in cure rate, low in probability of recurrence, free of toxic and side effects, low in cost, and purely natural.
Description
Technical field
The present invention relates to technical field of animal, particularly a kind of medicine for preventing and treating chicken infectious anemia.
Background technology
Chicken infectious anemia (Chickeninfectiousanemia, CIA) also known as blue wing disease, hemorrhagic syndrome or anemicus dermatitis syndrome, by Chicken Anemia Virus (CAV) (ChickenInfectiousAnemiaVirus, CIAV) infectious disease being principal character with chickling aplastic anemia and total lymphoid Telatrophy caused is a kind of important immunosuppressive disease.Because its clinical manifestation is not obvious, thus usually ignore by poultry feeders.But chicken group is once can cause the immunosuppressant of chicken body after infecting CIA, thus causes chicken group to strengthen the susceptibility of other bacterial diseases, virosis and parasitic disease, and provisions fowl industrial belt carrys out heavy economic losses.In addition, CIAV infects and the Vaccine effectiveness of some vaccine also can be caused to decline or strengthen the pathogenicity of attenuated vaccine, thus causes immuning failure, and provisions fowl industrial belt carrys out indirect economic loss.
Clinical symptoms:
After CIAV infects, whether chicken shows clinical symptoms, with age, the CIAV virulence of chicken and whether occur together or secondary Other diseases relevant.Main clinical characteristics is anemia.Sick chicken palor, hypoevolutism, spirit is depressed, and become thin, beak, wattle and visual mucosal pallor, wing dermatitis or blue wing, whole body petechial hemorrhage, start death after 2 ~ 3 days, mortality rate differs, and is generally 10% ~ 50%, and dying chicken is suffered from diarrhoea as seen.Secondary infection can hinder the rehabilitation of disease chicken, and aggravation is dead.
Western medical treatment chicken infectious anemia scheme is single, and the course for the treatment of is longer, clinical effectiveness is not obvious, even may therefore delay treatment, expand disease chicken range of infection.Further, prolonged application chemical synthetic drug toxic and side effects is large, drug residue is higher, and consumer eats this type of Carnis Gallus domesticus and produces its immunity of organisms.
But, Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, can benefiting vital QI and blood, strengthen chicken immunity, not easily recur after healing, cost price is cheap, in treatment chicken infectious anemia, application Chinese herbal medicine natural feed addictive can carry out marketing, has very important reality and clinical meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of chicken infectious anemia, and can strengthen chicken immunity, not easily recur after healing, cost price is cheap.
In order to realize foregoing invention object, the invention provides a kind of medicine for preventing and treating chicken infectious anemia, described medicine comprises following raw medicinal material: Herba Houttuyniae, Herba urenae procumbentis, Radix Sanguisorbae, Herba Chelidonii, Fructus nephelii topengii, Rhizoma Donacis canniformis, Folium et Ramulus Callicarpae nudiflorae, ligustrum sinense, Herba Beronicastri brunoniani, Radix Hemsleyae Macrospermae, blood-snow willow, Fructus Akebiae, Radix Glycyrrhizae, Citrus chachiensis Hort. (C. Suavissima Tanaka), Herba Cynomorii, Radix Morindae Officinalis, field grasswort, Flos Caraganae Sinicae, Radix Fortunellae Margaritae, Ficus fulva Reinw., Ramulus Cinnamomi, Folium Nelumbinis Basis, Resina Liquidambaris, Lignum Sappan, Flos Campsis, Radix Polygalae, Herba Pyrolae, Flos Limonii Aurei, Herba seu radix metaplexis and Radix Rhodiolae Dumulosae.
In described medicine, the parts by weight of each raw medicinal material are: Herba Houttuyniae 9-17 weight portion, Herba urenae procumbentis 10-14 weight portion, Radix Sanguisorbae 7-11 weight portion, Herba Chelidonii 3-6 weight portion, Fructus nephelii topengii 9-15 weight portion, Rhizoma Donacis canniformis 8-17 weight portion, Folium et Ramulus Callicarpae nudiflorae 11-20 weight portion, ligustrum sinense 15-25 weight portion, Herba Beronicastri brunoniani 12-21 weight portion, Radix Hemsleyae Macrospermae 5-8 weight portion, blood-snow willow 4-8 weight portion, Fructus Akebiae 10-17 weight portion, Radix Glycyrrhizae 8-16 weight portion, Citrus chachiensis Hort. (C. Suavissima Tanaka) 11-19 weight portion, Herba Cynomorii 16-27 weight portion, Radix Morindae Officinalis 25-35 weight portion, field grasswort 6-11 weight portion, Flos Caraganae Sinicae 15-26 weight portion, Radix Fortunellae Margaritae 18-37 weight portion, Ficus fulva Reinw. 14-25 weight portion, Ramulus Cinnamomi 18-31 weight portion, Folium Nelumbinis Basis 7-15 weight portion, Resina Liquidambaris 18-31 weight portion, Lignum Sappan 6-13 weight portion, Flos Campsis 17-25 weight portion, Radix Polygalae 15-27 weight portion, Herba Pyrolae 15-27 weight portion, Flos Limonii Aurei 8-15 weight portion, Herba seu radix metaplexis 13-16 weight portion and Radix Rhodiolae Dumulosae 10-15 weight portion.
In described medicine, the parts by weight of each raw medicinal material are: Herba Houttuyniae 9 weight portion, Herba urenae procumbentis 10 weight portion, Radix Sanguisorbae 11 weight portion, Herba Chelidonii 6 weight portion, Fructus nephelii topengii 15 weight portion, Rhizoma Donacis canniformis 8 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, ligustrum sinense 15 weight portion, Herba Beronicastri brunoniani 12 weight portion, Radix Hemsleyae Macrospermae 8 weight portion, blood-snow willow 4 weight portion, Fructus Akebiae 17 weight portion, Radix Glycyrrhizae 8 weight portion, Citrus chachiensis Hort. (C. Suavissima Tanaka) 19 weight portion, Herba Cynomorii 16 weight portion, Radix Morindae Officinalis 25 weight portion, field grasswort 11 weight portion, Flos Caraganae Sinicae 26 weight portion, Radix Fortunellae Margaritae 18 weight portion, Ficus fulva Reinw. 14 weight portion, Ramulus Cinnamomi 31 weight portion, Folium Nelumbinis Basis 15 weight portion, Resina Liquidambaris 31 weight portion, Lignum Sappan 6 weight portion, Flos Campsis 17 weight portion, Radix Polygalae 15 weight portion, Herba Pyrolae 27 weight portion, Flos Limonii Aurei 15 weight portion, Herba seu radix metaplexis 16 weight portion and Radix Rhodiolae Dumulosae 10 weight portion.
In described medicine, the parts by weight of each raw medicinal material are: Herba Houttuyniae 17 weight portion, Herba urenae procumbentis 14 weight portion, Radix Sanguisorbae 7 weight portion, Herba Chelidonii 3 weight portion, Fructus nephelii topengii 9 weight portion, Rhizoma Donacis canniformis 17 weight portion, Folium et Ramulus Callicarpae nudiflorae 11 weight portion, ligustrum sinense 25 weight portion, Herba Beronicastri brunoniani 21 weight portion, Radix Hemsleyae Macrospermae 5 weight portion, blood-snow willow 8 weight portion, Fructus Akebiae 10 weight portion, Radix Glycyrrhizae 16 weight portion, Citrus chachiensis Hort. (C. Suavissima Tanaka) 11 weight portion, Herba Cynomorii 27 weight portion, Radix Morindae Officinalis 35 weight portion, field grasswort 6 weight portion, Flos Caraganae Sinicae 26 weight portion, Radix Fortunellae Margaritae 37 weight portion, Ficus fulva Reinw.-25 weight portion, Ramulus Cinnamomi 18 weight portion, Folium Nelumbinis Basis 7 weight portion, Resina Liquidambaris 18 weight portion, Lignum Sappan 13 weight portion, Flos Campsis 25 weight portion, Radix Polygalae 27 weight portion, Herba Pyrolae 15 weight portion, Flos Limonii Aurei 8 weight portion, Herba seu radix metaplexis 13 weight portion and Radix Rhodiolae Dumulosae 15 weight portion.
For preventing and treating a medicine for chicken infectious anemia, preparation method comprises the following steps:
The first step, each component in described medicine is mixed in proportion, drops into pulverizer and carry out pulverizing or directly shredding, load and decoct in container, add suitable quantity of water and make its submergence medical material, soak after 10-25 minute, be heated to boiling after 40-70 minute, be separated fried liquid, medicinal residues again add water and carry out decoction 2-3 time, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue;
Second step, after liquid cooling but to be filtered, adding relative to concentrated rear liquid weight 1-2 determining alcohol is doubly 80-90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, obtain filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol is that the ethanol of 50-60% is cleaned, and collects washing liquid and merges with filtrate, after ethanol is regained in decompression, dislocation lets cool place, leaves standstill 0.5-1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtain paste;
3rd step: paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C-200 DEG C, leaving air temp 70 DEG C-90 DEG C, is ground into 300 order-400 orders subsequently, obtains medicine.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention has eliminating inflammation and expelling toxin, enrich blood invigorate blood circulation, effect of spleen benefiting and stimulating the appetite, control chicken infectious anemia.The present invention utilizes Traditional Chinese medical theory, great attention to whole idea: determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and specific aim is comparatively strong, evident in efficacy; Each herbal medicine contains multiple pharmaceutical component, evident in efficacy; Can strengthen chicken immunity, cure rate is high, not easily recurs, and pure natural, has no side effect, and cost price is cheap.
Detailed description of the invention
The invention provides a kind of medicine for preventing and treating chicken infectious anemia, described medicine comprises following raw medicinal material: Herba Houttuyniae, Herba urenae procumbentis, Radix Sanguisorbae, Herba Chelidonii, Fructus nephelii topengii, Rhizoma Donacis canniformis, Folium et Ramulus Callicarpae nudiflorae, ligustrum sinense, Herba Beronicastri brunoniani, Radix Hemsleyae Macrospermae, blood-snow willow, Fructus Akebiae, Radix Glycyrrhizae, Citrus chachiensis Hort. (C. Suavissima Tanaka), Herba Cynomorii, Radix Morindae Officinalis, field grasswort, Flos Caraganae Sinicae, Radix Fortunellae Margaritae, Ficus fulva Reinw., Ramulus Cinnamomi, Folium Nelumbinis Basis, Resina Liquidambaris, Lignum Sappan, Flos Campsis, Radix Polygalae, Herba Pyrolae, Flos Limonii Aurei, Herba seu radix metaplexis and Radix Rhodiolae Dumulosae.
Wherein, Herba Houttuyniae, Herba urenae procumbentis, Radix Sanguisorbae, Herba Chelidonii, Fructus nephelii topengii, Rhizoma Donacis canniformis, Folium et Ramulus Callicarpae nudiflorae, ligustrum sinense, Herba Beronicastri brunoniani, Radix Hemsleyae Macrospermae, blood-snow willow eliminating inflammation and expelling toxin; Fructus Akebiae, Radix Glycyrrhizae, Citrus chachiensis Hort. (C. Suavissima Tanaka) is soothing the liver removing toxic substances; Herba Cynomorii, Radix Morindae Officinalis, field grasswort and Flos Caraganae Sinicae QI invigorating kidney tonifying; Radix Fortunellae Margaritae, Ficus fulva Reinw., Ramulus Cinnamomi, Folium Nelumbinis Basis invigorating the spleen and benefiting QI; Resina Liquidambaris, Lignum Sappan, Flos Campsis, Radix Polygalae, Herba Pyrolae, Flos Limonii Aurei, Herba seu radix metaplexis, Radix Rhodiolae Dumulosae blood circulation promoting and enriching nourish blood.
The pharmacology of each crude drug is as follows:
Herba Houttuyniae: another name Herba Houttuyniae, hog snout hole, Herba rutae, fish scale grass.This product is the dry aerial parts of saururaceae plant houttuynia cordata.Pungent, be slightly cold.[return through] returns lung meridian.[function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
Herba urenae procumbentis: another name Acer buergerianum Miq., three closes maple, Hong Kong Herba anemones vitifoliae, dog fall mark, dog fall pawl.For the herb of Malvaceae plant Herba urenae procumbentis.Sweet; Bitter; Cool in nature.[return through] liver; Large intestine channel.[function cures mainly] expelling wind and removing dampness; Heat reliving and toxin-eliminating.Main air pain of dampness syndrome; Have loose bowels; Dysentery; Flu; Laryngopharynx swelling and pain; Cough due to lung-heat; Pathogenic wind toxic multiple abscess; Sore swollen toxin; Traumatic injury; Venom.
Radix Sanguisorbae: another name Matteuccia struthiopteri, beautiful letter, Fructus Choerospondiatis.This product is the dry root of rosaceous plant Radix Sanguisorbae or the Radix Sanguisorbae that comes into leaves.Bitter, sour, puckery, be slightly cold.[function cures mainly] cooling blood for hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Herba Chelidonii: another name mountain Rhizoma Coptidis, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), Niu Jinhua, eight steps are tight, Gelsemium elegans Benth. [Beijing].For Papaveraceae Chelidonium plant Herba Chelidonii, with all herbal medicine.Hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, pain relieving, cough-relieving.For gastritis, gastric ulcer, stomachache, enteritis, dysentery, jaundice, chronic tracheitis, pertussis; Paddy-field dermatitis is controlled in external, insect-bite.
Fructus nephelii topengii: another name mountain Fructus nephelii topengii (" Gui Haiyu weigh will "), hair Fructus Litchi (" Zhiwu Mingshi Tukao "), hair is called together (" Luchuan is herbal ").For the fruit of sapindaceous plant Fructus nephelii topengii.Sweet; Acid; Temperature.Return spleen; Stomach warp.Cold expelling; Dysentery relieving; Removing toxic substances.Main dysentery; Trusted subordinate's cold type of pain; Skin infection.
Rhizoma Donacis canniformis: another name dagger-axe swallow [Dai Nationality's name].Marantaceae Rhizoma Donacis canniformis, is used as medicine with tuber or stem.Light, cool.Heat-clearing and toxic substances removing, relieving cough and relieving asthma, anti-inflammation and sterilization.Cure mainly pulmonary tuberculosis, tracheitis, bronchitis, asthma, high heat, infantile measles, merges pneumonia, flu, heating, various dermatosis.
Folium et Ramulus Callicarpae nudiflorae: another name successively red, meal soup leaf, crafty man's medicine, large Strepopelia orientalis rice, spend tea in vain.Medical material Ji Yuan: be the leaf with twig of Verbenaceae Callicarpa nudiflora.Puckery micro-arduous; Flat.Heart channel.Dissipating blood stasis stops blooding; Removing toxic substances and promoting subsidence of swelling.Main epistaxis; Hemoptysis; Spit blood; Have blood in stool; Traumatic injury congestive edema; Traumatic hemorrhage; Burn due to hot liquid or fire; Sore festers.
Ligustrum sinense: the young tree of another name mosquito, Ilicis Purpureae, Ligustrum sinense, mosquito flower, Rheum alexandrae Batal. poplar, thousand sheets tree, mountain are avenged son, Pericarpium Citri Reticulatae Viride tree, water dog bone, turned green pepper, Man Dihong, native Folium Camelliae sinensis, little knife injury.Oleaceae Ligustrum plant ligustrum sinense, is used as medicine with leaf.Hardship, cold.[function cures mainly] heat-clearing and toxic substances removing, bacteriostasis and sterilization, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting.For acute icteric infectious hepatitis, dysentery, cough due to lung-heat; Traumatic injury is controlled in external, traumatic infection, burn and scald.The surgical infection diseases such as sore swollen toxin.
Herba Beronicastri brunoniani: another name high mountain Herba Veronicastri caulopteri, Radix vernoniae asperae, cough medicine, YEXIAHONG, Slight Cold medicine, the anti-back of the body are red.Scrophulariaceae Herba Beronicastri brunoniani, is used as medicine with root stock.Hardship, cold.[function cures mainly] eliminating inflammation and expelling toxin, relieving cough and resolving phlegm, lowering the adverse-rising QI to subdue asthma, reducing swelling and alleviating pain.Cure mainly tonsillitis, gastric heat pain, cystitis, mastitis, carbuncle sore tumefacting virus, dysentery, chronic tracheitis etc.
Radix Hemsleyae Macrospermae: golden basin (" vegetation is side just "), Gold Testudinis lotus (" Revision and Addition Tian Bao book on Chinese herbal medicine "), gold silver basin (" classifying herbal "), native Fructus Aristolochiae (" Traditional Chinese Medicine in Sichuan will "), Jin Yaolian, Hemsleya amabilis Diels (" full exhibition a collection of selected materials surgery "), bitter golden basin (" choosing of Yunnan Chinese herbal medicine ").[source] is the tuber of cucurbitaceous plant large seed Radix Hemsleyae Macrospermae, lovely Radix Hemsleyae Macrospermae and Chinese Radix Hemsleyae Macrospermae etc.Bitter in the mouth; Cold in nature; GUIXIN; Stomach; Large intestine channel.Heat-clearing and toxic substances removing; Inducing diuresis and reducing edema; Analgesic hemostatic.Main laryngopharynx swelling and pain; Toothache; Conjunctival congestion and swelling pain; Stomachache; Bacillary dysentery; Intestinal is scorching; Hepatitis; Urinary tract infection; Prostatitis; Hemorrhoid; Cervicitis; Carbuncle furuncle; Traumatic hemorrhage.
Blood-snow willow: the red large fontanesia of another name, large fontanesia, fontanesia, Dali Herba Lobeliae Sessilifoliae.Campanulaceae blood-snow willow, is used as medicine with root.Pungent, cool.[function cures mainly] anti-inflammatory analgetic, sterilization, removing toxic substances.Cure mainly malaria.
Fructus Akebiae: another name Yan Xuzi (numerous in the Meng), poultry stores son, takes son (supplement to the Herbal), small wooden raft Im (" feeding habits book on Chinese herbal medicine ").For BENTONG section plant Caulis Akebiae
,threeleaf akebia
,the fruit of Bai Bentong.Hide micro-hardship, property is put down.Return liver, stomach, urinary bladder channel.Return liver; Stomach warp.Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Citrus chachiensis Hort. (C. Suavissima Tanaka): originate as the leaf of the multiple Citrus chachiensis Hort. classes such as rutaceae Citrus reticulata Blanco cv. Chachiensis or bowl Citrus chachiensis Hort..Pungent; Bitter; Flat.Return spleen; Stomach; Liver Channel.Circulation of qi promoting the chest stuffiness relieving; Dispersing the stagnated liver-QI for regulating the stomach; Removing toxicity for eliminating carbuncles.Main septum pectorale is full vexed; Distending pain over the hypochondrium; Blockage of menstruation; Diaphragm carbuncle; Acute mastitis; Breast carcinoma.
Herba Cynomorii: sweet, temperature.Return spleen, kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Soft for waist knee joint flaccidity, sexual impotence spermatorrhea, dryness of the intestine constipation.
Radix Morindae Officinalis: another name Radix Morindae Officinalis, Herba Morindae Parvifoliae, Caulis Gneti brill, the young intestinal of rabbit, triangle vine, bran rattan.This product is the dry root of Maguireothamnus speciosus Radix Morindae Officinalis.Sweet, pungent, tepor.Return kidney, Liver Channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Field grasswort: another name field grasswort.Medical material Ji Yuan: be the herb of pinkwort field grasswort.Light; Warm in nature.Nourishing YIN and invigorating YANG.Main negative and positive virtual loss card.
Flos Caraganae Sinicae: another name hemopoietic grass [Yunnan], Herba Parocheti Communis.Pulse family Cytisus plant Flos Caraganae Sinicae, with all herbal medicine.Sour, puckery, temperature.Kidney invigorating and YANG supporting, synthetism is stopped blooding.For impotence due to deficiency of the kidney; Wound hemorrhage is controlled in external, injury and bone fracture.
Radix Fortunellae Margaritae: another name elderly person for whom a birthday celebration is being held Citrus chachiensis Hort. root (" Traditional Chinese Medicine in Sichuan will ").For the root of rutaceae Fructus Fortunellae Margaritae and golden bullet.Sour in the mouth; Bitter; Warm in nature.Return spleen; Stomach; Liver Channel.Promoting the circulation of QI to relieve pain; Dissipating phlegm and resolving masses.Main epigastric distending pain; Hernia; Puerperal abdonimal pain; Uterine prolapse; Scrofula from the beginning of.
Ficus fulva Reinw.: the another name tiger palm, crow wind, amnesty mother-in-law tree, hair.Moraceae Ficus fulva Reinw., is used as medicine with root bark.Sweet, flat.Invigorating the spleen and benefiting QI, promoting blood circulation by removing wind.Curing mainly deficient qi and blood, uterine prolapse, proctoptosis, edema, rheumatic arthralgia, has loose bowels in loose stool.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi.Acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Folium Nelumbinis Basis: another name lotus nose (supplement to the Herbal), Lian Di (" south of the Five Ridges gather medicinal herbs record ").For the leaf base of nymphaeaceae plant lotus.Bitter; Puckery; Flat.Return spleen; Liver; Large intestine channel.Expelling summer-heat dries; Hemostasis by removing blood stasis; Antiabortive.Main diarrhea due to summer heat and dampness; Dysentery; Metrostaxis; Gestation frequent fetal movement.1. supplement to the Herbal: main antiabortive, removes stagnant blood, has stayed blood, dysentery, boil and take it.2. " Bencao Tujing ": main QI invigorating.3. " product remittance essence is wanted ": separate the wild gill fungus of food malicious, decocting in water takes it.4. " book on Chinese herbal medicine is new again ": clearing heart fire, expelling summer-heat relieving restlessness, controls dysentery and rushes down, and disappears damp and hot.5. " book on Chinese herbal medicine asks former ": antiabortive, only collapse, spleen invigorating.6. " Traditional Chinese Medicine in Sichuan will ": stimulate the menstrual flow, circulation of qi promoting, heat clearing away.7. " herbal classic is met former ": enter taste medicine but with its (Folium Nelumbinis) base of a fruit, get it and be richly better than elsewhere also.8. " beautiful Chinese catalpa medicine solution ": Folium Nelumbinis Basis, all medicines can be led until top, top.
Resina Liquidambaris: another name Resina Liquidambaris.This product is the dry resin of Hamamelidaceae Plants Chinese sweet gum.Pungent, bitter, flat; Return spleen, lung, Liver Channel.Function expelling wind and activating blood circulation, removing toxic substances pain relieving, hemostasia and promoting granulation.For carbuncle, skin ulcer rash, scrofula, toothache, arthralgia pain, paralysis, spits blood, epistaxis, spitting of blood, traumatic hemorrhage, chapped skin.
Lignum Sappan: another name lignum sappan.This product is the dry duramen of pulse family Caesalpinia Lignum Sappan.Sweet, salty, pungent, cool.Enter the heart, liver, stomach, spleen channel.Blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.As married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus.
Flos Campsis: another name Radix campsis, Herba Ipomoeae Cairicae, Flos Carthami Thalictrum omeiense W. T. Wang et S. H. Wang, fuchsia, the dragon that climbs the tree, Hedera nepalensis var. sinensis, white Canis familiaris L. intestinal, hanging screen flower, induced abortion flower this product are the dried floral and root that bavin Wei section plant is reached the clouds or reach the clouds in America.Sweet, sour, cold.Enter liver, pericardium channel.Promoting the circulation of blood blood stasis removing, cooling blood, expelling wind.For Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.
Radix Polygalae: another name Caulis et Folium Polygalae Tenuifoliae, Herba Ceratophylli Demeersi, Chicken Drumsticks, Roots of Polygala tenuifolia, line tea.This product is the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.Bitter, pungent, tepor.Enter the heart, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence insomnia and dreamful sleep, forgetful palpitation with fear, staring spells.Insomnia and dreamful sleep, severe palpitation, forgetful.
Herba Pyrolae: another name Herba pyrolae japonicae, Herba Pyrolae, deer peace tea, Herba pyrolae japonicae, checkerberry, Pyrola rotundifolia ssp.chinensis, Herba Polygalae Telephioidis [Sichuan].This product is the dry herb of Pyrolaceae plant Herba pyrolae japonicae or ovum leaf Herba pyrolae japonicae.Sweet; Bitter; Warm in nature.Return liver; Kidney channel.The kidney invigorating bone strengthening; Expelling wind and removing dampness; Cough-relieving; Hemostasis.Main lumbago due to renal deficiency; Rheumatic arthralgia; Muscles and bones flaccidity is soft; New chronic cough is coughed; Spit blood; Epistaxis; Metrorrhagia; Traumatic hemorrhage.
Flos Limonii Aurei: be the flower of Plumbaginaceae plant Herba Limonii Gmelinii with yellow flower.Light, cool.Pain relieving, antiinflammatory, enriches blood.Training the mind dysmenorrhoea for oral administration, the moon infrequent menstruation, hypogalactia, tinnitus; Various inflammation is controlled in external.
Herba seu radix metaplexis: another name Bai Huanteng, Herba seu Radix Metaplexis hemsleyanae, Pericarpium Metaplexis, grandmother's sewing kit, Metaplexis japonica (Thunb.)Makino.For herb or the root of asclepiadaceae plant Herba seu radix metaplexis.Gan Xin is flat.Nourishing the essence and strengthening QI, lactogenesis, removing toxic substances.Control deficient impairment caused by overstrain, sexual impotence, leukorrhagia, galactostasis, red carbuncle toxin.
Radix Rhodiolae Dumulosae: another name Herba Pteridis Multifidae, FENGHUACAO, Sedum dumulosum.Crassulaceae Rhodida plant Rhodiola dumulosa, with all herbal medicine.Sweet, micro-hardship, puckery, temperature.Tonifying blood and regulating menstruation, yin nourishing.For menoxenia, deficiency of YIN hectic fever, has a dizzy spell, women's asthenia.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The toxicity test of embodiment 1 medicine of the present invention
Get Herba Houttuyniae 9g, Herba urenae procumbentis 10g, Radix Sanguisorbae 11g, Herba Chelidonii 6g, Fructus nephelii topengii 15g, Rhizoma Donacis canniformis 8g, Folium et Ramulus Callicarpae nudiflorae 20g, ligustrum sinense 15g, Herba Beronicastri brunoniani 12g, Radix Hemsleyae Macrospermae 8g, blood-snow willow 4g, Fructus Akebiae 17g, Radix Glycyrrhizae 8g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 19g, Herba Cynomorii 16g, Radix Morindae Officinalis 25g, field grasswort 11g, Flos Caraganae Sinicae 26g, Radix Fortunellae Margaritae 18g, Ficus fulva Reinw. 14g, Ramulus Cinnamomi 31g, Folium Nelumbinis Basis 15g, Resina Liquidambaris 31g, Lignum Sappan 6g, Flos Campsis 17g, Radix Polygalae 15g, Herba Pyrolae 27g, Flos Limonii Aurei 15g, Herba seu radix metaplexis 16g, Radix Rhodiolae Dumulosae 10g, after mix homogeneously, pulverize, in the mixture after pulverizing, add the water of 1400g, decoct 2.5 hours, filter, the water adding 600g in filtering residue decocts 2 hours again, filters, and by twice filtrate mixing, is evaporated to the decoct that crude drug concentration is 3g/ml.
Get ICR mice, body weight, at 25-30 gram, by body weight random packet, often organizes 10, male and female half and half, oral administration solution administration, and dosage is only 6.0ml/.Continuous Observation 20 days after administration, all mices of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable.
Embodiment 2 medicine 1 of the present invention and preparation method
Get Herba Houttuyniae 9g, Herba urenae procumbentis 10g, Radix Sanguisorbae 11g, Herba Chelidonii 6g, Fructus nephelii topengii 15g, Rhizoma Donacis canniformis 8g, Folium et Ramulus Callicarpae nudiflorae 20g, ligustrum sinense 15g, Herba Beronicastri brunoniani 12g, Radix Hemsleyae Macrospermae 8g, blood-snow willow 4g, Fructus Akebiae 17g, Radix Glycyrrhizae 8g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 19g, Herba Cynomorii 16g, Radix Morindae Officinalis 25g, field grasswort 11g, Flos Caraganae Sinicae 26g, Radix Fortunellae Margaritae 18g, Ficus fulva Reinw. 14g, Ramulus Cinnamomi 31g, Folium Nelumbinis Basis 15g, Resina Liquidambaris 31g, Lignum Sappan 6g, Flos Campsis 17g, Radix Polygalae 15g, Herba Pyrolae 27g, Flos Limonii Aurei 15g, Herba seu radix metaplexis 16g, Radix Rhodiolae Dumulosae 10g, drop into pulverizer to pulverize, Chinese medicine composition after pulverizing is loaded in decoction container, add suitable quantity of water and make its submergence medical material, soak after 10 minutes, be heated to boiling after 70 minutes, be separated fried liquid, medicinal residues again add water and carry out decoction 3 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue, after liquid cooling but to be filtered, adding relative to the determining alcohol of concentrated rear liquid weight 1 times is 90% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, and obtains filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol be 60% ethanol clean, collect washing liquid and also merge with filtrate, after decompression withdrawal ethanol, dislocation lets cool place, leave standstill 1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtains paste, paste is put into spray dryer dry, ensure that inlet temperature is at 180 DEG C, leaving air temp 90 DEG C, is ground into 330 orders subsequently, obtains medicine 1.
Embodiment 3 medicine 2 of the present invention and preparation method
Get Herba Houttuyniae 17g, Herba urenae procumbentis 14g, Radix Sanguisorbae 7g, Herba Chelidonii 3g, Fructus nephelii topengii 9g, Rhizoma Donacis canniformis 17g, Folium et Ramulus Callicarpae nudiflorae 11g, ligustrum sinense 25g, Herba Beronicastri brunoniani 21g, Radix Hemsleyae Macrospermae 5g, blood-snow willow 8g, Fructus Akebiae 10g, Radix Glycyrrhizae 16g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 11g, Herba Cynomorii 27g, Radix Morindae Officinalis 35g, field grasswort 6g, Flos Caraganae Sinicae 26g, Radix Fortunellae Margaritae 37g, Ficus fulva Reinw.-25g, Ramulus Cinnamomi 18g, Folium Nelumbinis Basis 7g, Resina Liquidambaris 18g, Lignum Sappan 13g, Flos Campsis 25g, Radix Polygalae 27g, Herba Pyrolae 15g, Flos Limonii Aurei 8g, Herba seu radix metaplexis 13g, Radix Rhodiolae Dumulosae 15g, drop into pulverizer to pulverize, Chinese medicine composition after pulverizing is loaded in decoction container, add suitable quantity of water and make its submergence medical material, soak after 15 minutes, be heated to boiling after 60 minutes, be separated fried liquid, medicinal residues again add water and carry out decoction 3 times, the fried liquid that separated and collected is each, then after filtering, get filtrate and abandon filtering residue, after liquid cooling but to be filtered, adding relative to the determining alcohol of concentrated rear liquid weight 2 times is 80% ethanol, abundant mix homogeneously, placement is spent the night, and makes it precipitate, and obtains filtrate after getting its supernatant liquid filtering next day, precipitate determining alcohol be 50% ethanol clean, collect washing liquid and also merge with filtrate, after decompression withdrawal ethanol, dislocation lets cool place, leave standstill 0.5 hour, make precipitation complete, filter, filtrate low-temperature evaporation, obtains paste, paste is put into spray dryer dry, ensure that inlet temperature is at 200 DEG C, leaving air temp 80 DEG C, is ground into 300 orders subsequently, obtains medicine 2.
Embodiment 4 clinical trial
(1) experimental chicken and place are chosen:
6 chicken houses selecting Luoyang City are Experimental Base, random selecting 1 Japanese instar chickling 320, as treatment contrast test object.Healthy 1 Japanese instar chickling 320 of these 6 chicken houses of another random selecting is as prevention contrast test object.
(2) bacterial strain extracts:
Inspection is cutd open, the aseptic tissue such as thymus, bone marrow, spleen taking disease chicken to 16 infectious anemias in 6 chicken farms, Luoyang City chicken that dies of illness, the pathological material of disease gathered is ground with sterilizing PBS, 30min is acted at dual anti-37 DEG C of final concentration 1000 μ/ml, multigelation 3-4 time, centrifugal, supernatant adds 50% volume fraction chloroform give 15min, period not failure of oscillation shake, 70 DEG C of process 5min, centrifugal, supernatant is through 0.22 μm of membrane filtration, set low temperature refrigerator frozen, for subsequent use.
(3) contrast experiment is prevented:
320 of random choose 1 age in days healthy chicks are divided at random 4 groups (matched group 1, matched group 2 and embodiment group 1 and embodiment groups 2),
Wherein, matched group 1 and matched group 2 use traditional chicken feedstuff to feed chicken respectively;
Embodiment group 1 is fed after using the medicine 1 in embodiment 2 to mix with conventional feed chicken; Medicine is mixed in conventional feed according to the part by weight of 1:100;
Embodiment group 2 is fed after using the medicine 2 in embodiment 3 to mix with conventional feed chicken; Medicine is mixed in conventional feed according to the part by weight of 1:100;
After feeding 1 week, carry out the 5 times diluents of artificial challenge with culture for subsequent use to matched group 1, embodiment 1 group and embodiment 2 groups, only, observed and recorded respectively organizes sickness rate and the mortality rate of chicken to lumbar injection 0.3mL/, and result is as shown in table 1.
Table 1 preventive effect synopsis
Group | Sum | Artificial challenge's number | Sickness rate | Death toll | Mortality rate | Protective rate |
Embodiment group 1 | 80 | 80 | 1.3% | 0 | 0% | 100% |
Embodiment group 2 | 80 | 80 | 0% | 0 | 0% | 100% |
Matched group 1 | 80 | 80 | 100% | 35 | 44% | 56% |
Matched group 2 | 80 | 0 | 0 | 0 | 0 | 100% |
Data from table 1: the medicine 1 of the embodiment of the present invention 2 and the medicine of embodiment 32 pairs of chicken infectious anemias have obvious preventive effect.
(4) contrast test is treated:
4 groups of (medicine 1 treatment group, medicine 2 treatment groups are divided at random with 320 1 Japanese instar chicklings of the supernatant lumbar injection filtered, western medicine group, blank group), different medicine is taken after there is clinical symptoms, wherein, medicine 1 treatment group selects the medicine 1 of embodiment 2, dose be every every day 0.5g, treat 14 days; Medicine 2 treatment group selects the medicine 2 of embodiment 3, dose be every every day 0.5g, treat 14 days; Western medicine group selects chloromycetin 10mg/mL, norfloxacin 20mg/mL carries out neck injection, treats 14 days; Blank group does not feed any medicine.Observed and recorded respectively organizes the sickness rate of broiler, cure rate and mortality rate, and result is as shown in table 2.
Table 2 therapeutic effect synopsis
Group | Morbidity number | Sickness rate | Death toll | Mortality rate | Cure number | Cure rate |
Medicine 1 treatment group | 80 | 100% | 0 | 0% | 80 | 100% |
Medicine 2 treatment group | 80 | 100% | 0 | 0% | 80 | 100% |
Western medicine group | 80 | 100% | 19 | 23.8% | 61 | 76.2% |
Blank group | 80 | 100% | 28 | 35% | - | - |
Data from table 2: medicine 1 treatment group of the embodiment of the present invention 2 and medicine 2 treatment group of embodiment 3 are obviously better than western medicine group to chicken infectious anemia therapeutic effect, reduce mortality rate, improve cure rate.
Model case
Distributions in Liaocheng of Shandong Province raiser introduces chickling 3200 plumage from other places in August, 2012.Chicken performance inappetence after 3 weeks, become thin and size uneven, hat and the symptom such as skin of face and visual mucosa is pale, anemia, serious is even dead, diarrhoea on one's deathbed.Comprehensive inspection is carried out to the chicken that dies of illness, according to incidence, clinical symptoms, has cutd open inspection change and laboratory inspection is diagnosed as chicken group and has infected chicken infectious anemia.To symptom be there is and not occur the chicken isolation processing of symptom at once.Choose wherein 100 use the medicine 1 in embodiments 2 to mix with conventional feed after to feed chicken; Medicine is mixed in conventional feed according to the part by weight of 1:100.After feeding 3 days, the spirit of chicken is clearly better, and appetite increases, and after feeding 14 days, 100 sick chickens are all fully recovered.Continue to feed chicken after 7 days, compared with healthy chicken, average weight is substantially identical.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. one kind for preventing and treating the medicine of chicken infectious anemia, it is characterized in that, described medicine comprises following raw medicinal material: Herba Houttuyniae, Herba urenae procumbentis, Radix Sanguisorbae, Herba Chelidonii, Fructus nephelii topengii, Rhizoma Donacis canniformis, Folium et Ramulus Callicarpae nudiflorae, ligustrum sinense, Herba Beronicastri brunoniani, Radix Hemsleyae Macrospermae, blood-snow willow, Fructus Akebiae, Radix Glycyrrhizae, Citrus chachiensis Hort. (C. Suavissima Tanaka), Herba Cynomorii, Radix Morindae Officinalis, field grasswort, Flos Caraganae Sinicae, Radix Fortunellae Margaritae, Ficus fulva Reinw., Ramulus Cinnamomi, Folium Nelumbinis Basis, Resina Liquidambaris, Lignum Sappan, Flos Campsis, Radix Polygalae, Herba Pyrolae, Flos Limonii Aurei, Herba seu radix metaplexis and Radix Rhodiolae Dumulosae.
2. medicine according to claim 1, is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Houttuyniae 9-17 weight portion, Herba urenae procumbentis 10-14 weight portion, Radix Sanguisorbae 7-11 weight portion, Herba Chelidonii 3-6 weight portion, Fructus nephelii topengii 9-15 weight portion, Rhizoma Donacis canniformis 8-17 weight portion, Folium et Ramulus Callicarpae nudiflorae 11-20 weight portion, ligustrum sinense 15-25 weight portion, Herba Beronicastri brunoniani 12-21 weight portion, Radix Hemsleyae Macrospermae 5-8 weight portion, blood-snow willow 4-8 weight portion, Fructus Akebiae 10-17 weight portion, Radix Glycyrrhizae 8-16 weight portion, Citrus chachiensis Hort. (C. Suavissima Tanaka) 11-19 weight portion, Herba Cynomorii 16-27 weight portion, Radix Morindae Officinalis 25-35 weight portion, field grasswort 6-11 weight portion, Flos Caraganae Sinicae 15-26 weight portion, Radix Fortunellae Margaritae 18-37 weight portion, Ficus fulva Reinw. 14-25 weight portion, Ramulus Cinnamomi 18-31 weight portion, Folium Nelumbinis Basis 7-15 weight portion, Resina Liquidambaris 18-31 weight portion, Lignum Sappan 6-13 weight portion, Flos Campsis 17-25 weight portion, Radix Polygalae 15-27 weight portion, Herba Pyrolae 15-27 weight portion, Flos Limonii Aurei 8-15 weight portion, Herba seu radix metaplexis 13-16 weight portion, Radix Rhodiolae Dumulosae 10-15 weight portion.
3. according to the arbitrary described medicine of claim 1-2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Houttuyniae 9 weight portion, Herba urenae procumbentis 10 weight portion, Radix Sanguisorbae 11 weight portion, Herba Chelidonii 6 weight portion, Fructus nephelii topengii 15 weight portion, Rhizoma Donacis canniformis 8 weight portion, Folium et Ramulus Callicarpae nudiflorae 20 weight portion, ligustrum sinense 15 weight portion, Herba Beronicastri brunoniani 12 weight portion, Radix Hemsleyae Macrospermae 8 weight portion, blood-snow willow 4 weight portion, Fructus Akebiae 17 weight portion, Radix Glycyrrhizae 8 weight portion, Citrus chachiensis Hort. (C. Suavissima Tanaka) 19 weight portion, Herba Cynomorii 16 weight portion, Radix Morindae Officinalis 25 weight portion, field grasswort 11 weight portion, Flos Caraganae Sinicae 26 weight portion, Radix Fortunellae Margaritae 18 weight portion, Ficus fulva Reinw. 14 weight portion, Ramulus Cinnamomi 31 weight portion, Folium Nelumbinis Basis 15 weight portion, Resina Liquidambaris 31 weight portion, Lignum Sappan 6 weight portion, Flos Campsis 17 weight portion, Radix Polygalae 15 weight portion, Herba Pyrolae 27 weight portion, Flos Limonii Aurei 15 weight portion, Herba seu radix metaplexis 16 weight portion, Radix Rhodiolae Dumulosae 10 weight portion.
4. according to the arbitrary described medicine of claim 1-2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Houttuyniae 17 weight portion, Herba urenae procumbentis 14 weight portion, Radix Sanguisorbae 7 weight portion, Herba Chelidonii 3 weight portion, Fructus nephelii topengii 9 weight portion, Rhizoma Donacis canniformis 17 weight portion, Folium et Ramulus Callicarpae nudiflorae 11 weight portion, ligustrum sinense 25 weight portion, Herba Beronicastri brunoniani 21 weight portion, Radix Hemsleyae Macrospermae 5 weight portion, blood-snow willow 8 weight portion, Fructus Akebiae 10 weight portion, Radix Glycyrrhizae 16 weight portion, Citrus chachiensis Hort. (C. Suavissima Tanaka) 11 weight portion, Herba Cynomorii 27 weight portion, Radix Morindae Officinalis 35 weight portion, field grasswort 6 weight portion, Flos Caraganae Sinicae 26 weight portion, Radix Fortunellae Margaritae 37 weight portion, Ficus fulva Reinw.-25 weight portion, Ramulus Cinnamomi 18 weight portion, Folium Nelumbinis Basis 7 weight portion, Resina Liquidambaris 18 weight portion, Lignum Sappan 13 weight portion, Flos Campsis 25 weight portion, Radix Polygalae 27 weight portion, Herba Pyrolae 15 weight portion, Flos Limonii Aurei 8 weight portion, Herba seu radix metaplexis 13 weight portion, Radix Rhodiolae Dumulosae 15 weight portion.
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CN103479831A (en) * | 2013-08-29 | 2014-01-01 | 青岛绿曼生物工程有限公司 | Pure Chinese herbal composition for treating chicken infectious anemia and preparation method thereof |
CN103931957A (en) * | 2014-05-13 | 2014-07-23 | 山东新希望六和集团有限公司 | Chicken feed and traditional Chinese medicine composition for preventing and treating chicken infectious anemia |
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CN103931957A (en) * | 2014-05-13 | 2014-07-23 | 山东新希望六和集团有限公司 | Chicken feed and traditional Chinese medicine composition for preventing and treating chicken infectious anemia |
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CN107927343A (en) * | 2017-11-30 | 2018-04-20 | 南宁学院 | A kind of additive for preventing chicken infectious anemia |
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