CN108714167B - A Chinese medicinal preparation for external use for treating vitiligo, and its preparation method - Google Patents

Abstract

A traditional Chinese medicine external preparation for treating leucoderma is prepared from the following raw materials in parts by weight: 150-200 parts of fructus psoraleae, 100-150 parts of rhizoma drynariae, 20-30 parts of caulis spatholobi, 20-30 parts of cynanchum paniculatum, 20-30 parts of salvia miltiorrhiza, 20-30 parts of cassia twig, 20-30 parts of cinnamon, 20-30 parts of elecampane, 20-30 parts of gallnut, 25-35 parts of berchemia lineate, 20-30 parts of sappan wood, 20-30 parts of radix astragali, 20-30 parts of semen cuscutae, 20-30 parts of hispid fig root, 20-30 parts of polygala fallax hemsl, 20-30 parts of mirabilite and 1500-2100 parts of 50% distilled grain wine. The invention has simple formula and simple and convenient preparation process, can promote blood circulation to remove stagnancy and activate tyrosinase activity, thereby recovering or accelerating the generation and transfer of melanin and recovering pigment of pathological skin with quick response.

Description

A Chinese medicinal preparation for external use for treating vitiligo, and its preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicine external preparations, in particular to a traditional Chinese medicine external preparation for treating leucoderma and a preparation method thereof.

Technical Field

Vitiligo is a common skin disease, and is an acquired skin pigment loss disease, and the morbidity is 0.5-2%. The reasons for the attack of the vitiligo are mainly that the vitiligo is formed due to the blood heat or body heat of a human body, external wind, dampness and rheumatism invasion into the skin, which cause local qi and blood disorder, meridian obstruction, blood deficiency and skin nourishment, qi stagnation and pore occlusion; vitiligo is also easily caused by trauma; the same pathology of a mole of nevus can be summarized as one of vitiligo. The disease is white spots at the beginning, and the disease spreads into spots for a long time, and the hair is indefinite, which affects the beauty of human body. Early vitiligo is often overlooked and misdiagnosed. Vitiligo is caused by endocrine and immune dysfunction, deficiency of trace elements, genetic factors, etc. The disease is common in the world and can be suffered by various families, and the disease is difficult to treat because local pigment loss affects beauty treatment and is easy to diagnose.

The traditional Chinese medicine theory considers that the onset of the leucoderma is the result of the interaction of internal and external factors of the body, the internal factor is liver-spleen-kidney deficiency, which is mostly caused by liver-blood deficiency, kidney-yang deficiency and kidney-qi deficiency to unbalance yin and yang of the body and disharmony of qi and blood, on the basis, damp-heat wind pathogen enters by deficiency, enters the skin, closes yin channels and collaterals and blood vessels, the skin cannot warm up, and skin and hair are nourished to cause melanin pigment loss to form leukoplakia. Generally, the external symptoms of the leucoderma are white at the affected part, are obvious in the boundary with normal skin color, do not protrude out of the skin, block pores, smooth in the skin of the affected part, free of scales and pains and itch, are distributed symmetrically mostly, and individual patients are accompanied by hair whitening and have no obvious symptoms before the disease occurs. The above causes are internal causes, external causes causing vitiligo are many and complicated, according to clinical observation, the following conditions of hand and foot heating in summer, especially serious in sleeping, appear before the vitiligo patient suffers from the disease in most different degrees; hyperhidrosis; poor sleep; the pressure of work, life or study is large; experiencing significant discomfort or wear; long term exposure to humid environments; exposing in the sun for a long time; wind is blown after sweating; the food collocation is unreasonable; (iii) has been subjected to trauma; overeating fishy and spicy pungent foods, and the like.

Various kinds of pollution are also a factor causing the increase of vitiligo patients year by year at present. The disease is not transmitted, and most patients are acquired in the acquired days. Vitiligo is often found in the rich sweat glands of face, neck, limbs, waist, abdomen and back of human body. The development is faster in spring and summer. Generally, the affected part is not painful and itchy. However, the affected part of some patients has itching, which indicates that the affected part has the tendency of spreading and developing. The leucoderma has a latent period, the disease condition does not develop temporarily, and the disease condition does not mean that the disease does not develop any more in the future. Once the patient has a cold, bad emotion, and is affected by external environmental stimulation, the condition will continue to develop. Many patients are unconscious in the early stage of vitiligo, have lucky psychology, often miss the best period of treatment, and need a long period of time for curing when the area is rather large.

Especially, if the disease is indefinite, the emotion and the future work and life of the patient can be affected if the disease is exposed to the external part, and if the disease is further developed into the systemic large-area vitiligo, the disease can cause unsmooth perspiration, skin cell metabolic disorder and possibly induce other diseases.

At present, the number of vitiligo patients in China is increased to tens of millions. Although the patients have no physical discomfort or malfunction, the patients may feel inferior due to the cosmetic abnormality or suffer from a bias in social interaction, which seriously endangers the psychological health of the people.

The vitiligo has many treatment methods, from medicine to instrument, from conservative treatment to operation, such as topical glucocorticoid, psoralen medicine, immunomodulator, traditional Chinese medicine, narrow spectrum medium wave ultraviolet ray, excimer laser, autologous epidermal transplantation, photochemotherapy, PUVA, etc., wherein the more used methods are ultraviolet ray therapy and hormone method, and the related preparations are covering agent, tincture, vinegar, powder, cream, fumigation lotion, etc., but the effect is not ideal, so the result is said to be the most promising at present, but the treatment method in the experimental stage is skin melanocyte transplantation therapy. The conventional therapies have different degrees of effects on treating the vitiligo, but the treatment is always temporary and permanent after the root is reached, only the epidermal symptoms can be relieved, and the complications are more, which are the common defects of a plurality of vitiligo treatment methods, such as diabetes, psoriasis, skin blistering and the like, and the diseases not only increase the treatment difficulty of the vitiligo, but also cause serious psychological trauma to patients.

For the disease, the cause is unknown, so an effective prevention method is not available, that is, no specific medicine can completely cure the vitiligo at present, the medicines for treating the vitiligo are various, and the medicines comprise traditional Chinese medicines and western medicines, and although the specific curative effect on the vitiligo is required, the specific curative effect on the vitiligo is incomplete, the vitiligo cannot be cured radically, the disease is easy to relapse, most of the medicines can only relieve symptoms, and the medicines have toxic and side effects. Therefore, research and development of a certain innovative medicine which can increase the efficiency of treating the leucoderma and does not bring new harm to human bodies is a work with great market prospect and great social significance. Aiming at the defects of the existing medicines for treating the leucoderma, for example, western medicine treatment mainly takes hormone treatment, but has long treatment period, great side effect, uncertain curative effect and difficult insistence, and the traditional Chinese medicine treatment method also has the laws of emergency treatment, slow root cause treatment and the like. The published literature also reports some traditional Chinese medicines for treating vitiligo, such as:

1. chinese patent: a Chinese medicinal ointment for treating vitiligo and its preparation method, application number: 201310263304.2, filing date: 2013.06.28, Applicant: baoding Huaren vitiligo hospital, address: 071000 Baoding Sanfenglu 379 number of Hebei province, inventor Wangping, abstract: the invention relates to a traditional Chinese medicine ointment for treating leucoderma and a preparation method thereof, which takes herba siegesbeckiae, fructus psoraleae, zaocys dhumnades, cinnamon, saffron and astragalus root as raw materials. Has effects in regulating immunity, activating tyrosinase, promoting black cell growth, improving photosensitivity, promoting blood circulation, dispelling blood stasis, and improving microcirculation. The invention is developed by combining the latest modern scientific research achievements on the basis of the traditional Chinese medicine dialectical treatment. The invention aims to provide a traditional Chinese medicine ointment for treating leucoderma and a preparation method thereof. Has the advantages of definite curative effect, safety, convenience, no toxic or side effect and low price.

2. Chinese patent: a traditional Chinese medicine external preparation for treating leucoderma, namely a dodder leucoderma tincture and a preparation method thereof, has the following application numbers: 201710950051.4, filing date: 2017.10.13, Applicant: shanghai good Huangpu pharmaceutical Co., Ltd, address: 201423 Shanghai Shangxian Hongzhulu No. 777, inventor: light of the square, Zhao Yun Fei, Zhang Chang Wei, Liu Fang, abstract: the invention discloses a traditional Chinese medicine external preparation, namely a dodder vitiligo tincture, for treating vitiligo, wherein each liter of the traditional Chinese medicine external preparation is prepared from the following raw materials: 200-300 g of dark plum fruit, 100-150 g of semen cuscutae, 60-lOOg of giant typhonium rhizome (prepared), 40-60 g of common cnidium fruit, 40-60 g of epimedium herb and the balance of ethanol with the volume percentage concentration of 85%. The invention has simple formula and simple and convenient preparation process, can promote blood circulation and remove stagnancy, inhibit epidermal sulfydryl and melanin tensin and activate tyrosinase activity, thereby recovering or accelerating the generation and transfer of melanin and recovering pigment from pathological skin, and has quick response and simple and convenient use. The invention also discloses a preparation method of the externally used traditional Chinese medicine preparation of the dodder vitiligo tincture for treating the vitiligo.

3. Chinese patent: a traditional Chinese medicine for treating leucoderma is disclosed on application day: 2005.9.5, application No. 200510098262.7, applicant: hypernym, address: 276006 Shandong province Linyi city gold one way and Linxi six ways junction west 200 m Shandong muddy hospital, inventor: hypernym, abstract: the invention discloses a Chinese herbal medicine Xiaobaikangling which is an ancestral Chinese herbal proved prescription special for treating leucoderma. Vitiligo is a limited white patch which occurs in the acquired nature due to depigmentation of skin. According to the pathology and the etiology, the pure traditional Chinese medicine preparation for treating the leucoderma is successfully researched by combining clinical comprehensive analysis, and the perplexity that the leucoderma is not cured for a long time in the past is broken. The compatibility of the invention is as follows: 30 g of angelica, 15 g of astragalus, 12 g of fleece-flower root, 30 g of human placenta, 15 g of eclipta, 35 g of tribulus terrestris, 6 long-noded pit vipers, 12 g of maytenus, 15 g of salvia miltiorrhiza, 12 g of peach kernel, 15 g of red peony root and 25 g of rhizoma atractylodis. The invention is prepared by adopting a conventional process, can promote the transformation of cells and pigments, strengthen the body resistance, invigorate blood circulation to eliminate pathogenic factors, dredge channels and remove dampness, ensure that the body resistance is sufficient, eliminate pathogenic factors, smooth qi and blood and eliminate leucoderma.

4. Chinese patent: a traditional Chinese medicine composition for treating vitiligo and a preparation method thereof are disclosed in application No. 201410424680. X, application date: 2014.08.25, Applicant: gougerontium, address: 629112 Tunning of Sichuan province, Yangxing county, hong Jiang Zhen Ma Qing Xilu 126, inventor: guolonghui, abstract: the invention relates to the field of vitiligo treatment, and in particular relates to a traditional Chinese medicine composition for treating vitiligo and a preparation method thereof. The traditional Chinese medicine composition for treating leucoderma comprises the following components in parts by weight: 20-30 parts of asclepiadaceae, 10-25 parts of semen cuscutae, 5-10 parts of safflower and 200 parts of alcohol. The traditional Chinese medicine composition for treating leucoderma provided by the invention has good efficacy and obvious curative effect, can be suitable for leucoderma suffered by various groups of people, and has obvious curative effect on leucoderma symptoms in various periods. In addition, the traditional Chinese medicine composition can be taken singly in the treatment process, other leucoderma medicines are not required to be mixed for use, and the traditional Chinese medicine composition is all natural Chinese herbal medicines, so that side effects (small) are avoided in the use process, and therefore, the traditional Chinese medicine composition provided by the invention is superior to the common medicines for treating leucoderma in the prior art from the aspects of medicine cost and safety.

5. Chinese patent: the medicine for treating leucoderma, the preparation method and the application thereof have the following application numbers: 201410018716.4, filing date: 2014.01.16, Applicant: fujian, songun, agriculture and forestry development ltd, address: 355100 Fujian province, Ningde city, Xiapu county, Songcheng city street, No. 478, floor 1, inventor: solemn dry fly, abstract: the invention relates to the technical field of medicines, in particular to a medicine for treating leucoderma and a preparation method and application thereof. The invention aims to solve the problems of medicaments for treating leucoderma in the prior art, and provides a medicament for treating leucoderma, which is prepared based on the photosensitization effect and the antioxidant, antibacterial and antiallergic effects of various plant extract components, has good curative effect, quick response, safe and reliable property, and no toxic or side effect, and raw materials are completely taken from the nature. The technical scheme of the invention is to provide a medicament for treating leucoderma, which comprises the following raw materials in parts by weight: polysaccharide of cassia seed: 0.2-25 parts; and (3) Moringa seed oil: 5-150 parts; purple perilla seed oil: 10-90 parts; perilla leaf oil: 1-10 parts. The product can generate pigmentation with different degrees in 7-14 days, can restore the pigment in 1-2 months on average, has good curative effect and quick response, is safe and reliable, and is convenient to use, and raw materials are completely taken from the nature.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine external preparation for treating leucoderma, which has simple components, ingenious combination and good curative effect.

In order to achieve the purpose, the invention adopts the technical scheme that:

a traditional Chinese medicine external preparation for treating leucoderma is prepared from the following raw materials in parts by weight: 150-200 parts of fructus psoraleae, 100-150 parts of rhizoma drynariae, 20-30 parts of caulis spatholobi, 20-30 parts of cynanchum paniculatum, 20-30 parts of salvia miltiorrhiza, 20-30 parts of cassia twig, 20-30 parts of cinnamon, 20-30 parts of elecampane, 20-30 parts of gallnut, 25-35 parts of berchemia lineate, 20-30 parts of sappan wood, 20-30 parts of radix astragali, 20-30 parts of semen cuscutae, 20-30 parts of hispid fig root, 20-30 parts of polygala fallax hemsl and 20-30 parts of mirabilite. Preferably: the traditional Chinese medicine external preparation is prepared from the following raw materials in parts by weight: 150 parts of fructus psoraleae, 100 parts of rhizoma drynariae, 25 parts of caulis spatholobi, 25 parts of paniculate swallowwort root, 25 parts of salvia miltiorrhiza, 25 parts of cassia twig, 25 parts of cinnamon, 25 parts of costus root, 25 parts of Chinese gall, 30 parts of berchemia lineate, 25 parts of sappan wood, 25 parts of radix scutellariae, 25 parts of semen cuscutae, 25 parts of hispid fig root, 25 parts of polygala fallax hemsl and 20 parts of mirabilite.

The preparation process of the traditional Chinese medicine external preparation for treating leucoderma comprises the following steps:

(1) taking fructus psoraleae, rhizoma drynariae, caulis spatholobi, paniculate swallowwort root, salvia miltiorrhiza, cassia twig, cinnamon, elecampane, gallnut, berchemia lineate, sappan wood, radix scutellariae, semen cuscutae, hispid fig root, radix polygalae fallax hemsl and mirabilite according to parts by weight, respectively crushing the fructus psoraleae, the rhizoma drynariae, the caulis spatholobi, the paniculate swallowwort root, the salvia miltiorrhiza, the cassia twig, the cinnamon, the elecampane, the gallnut, the hispid fig root, the sappan wood, the radix scutellariae, the semen cuscutae, the hispid fig root and the radix polygalae fallax;

(2) uniformly mixing fructus psoraleae coarse powder, rhizoma drynariae coarse powder, caulis spatholobi coarse powder, paniculate swallowwort root coarse powder, salvia miltiorrhiza coarse powder, berchemia lineata coarse powder, sappan wood coarse powder, radix scutellariae coarse powder, semen cuscutae coarse powder, hispid fig coarse powder and radix polygalae fallax coarse powder, putting into a container, adding 1500-2100 parts of distilled grain wine, sealing and soaking for 30 days, taking supernate and filtering, and keeping filtrate for later use;

(3) adding ramulus Cinnamomi coarse powder, cortex Cinnamomi coarse powder, radix aucklandiae coarse powder and Galla chinensis coarse powder into the filtrate, stirring, sealing, standing for 7 days, and collecting supernatant;

(4) adding Natrii sulfas into the supernatant, stirring, and filtering to obtain filtrate, which is the Chinese medicinal external preparation for treating vitiligo.

Preferably: the distilled liquor adopts distilled liquor with alcohol concentration of more than 50%.

Preferably: the distilled liquor is brewed by pure grains, and is fermented by grains or potatoes such as rice, sorghum, corn, sweet potato, potato and cassava.

The following is the information of various traditional Chinese medicines of the invention:

fructus psoraleae (academic name:PsoraleacorylifoliaLinn.) Also named: fructus Psoraleae, semen Strychni, and semen Allii Tuberosi. Belongs to Rosales, and is a standing herb of leguminous plants with a height of 60-150 cm. The leaf is a single leafThe length is 7-8 mm; the length of a leaf handle is 2-4.5 cm, the leaf width is oval, the inflorescence is axillary, 10-30 flowers exist, the corolla is yellow or blue, petals obviously have a petal handle, a flag petal is inverted oval, a pod is oval, and the flower and fruit period is 7-10 months. The fruit has effects of invigorating kidney, tonifying yang, invigorating spleen and stomach, and can be used for treating dermatoses such as psoriasis. Medicine property: bitter, pungent and warm. It enters kidney and spleen meridians. The efficacy is as follows: invigorating kidney, supporting yang, arresting spontaneous emission, arresting polyuria, treating lumbago due to kidney deficiency, frequent micturition, infantile enuresis, renal leakage, warming spleen, relieving diarrhea, and relieving asthma. The main treatment is as follows: 1. can be used for treating kidney deficiency, sexual impotence, soreness of waist and knees, psychroalgia, spermatorrhea, enuresis, frequent micturition, etc. 2. Can be used for treating diarrhea before dawn due to spleen and kidney yang deficiency. 3. Can be used for treating cough and asthma due to deficiency cold caused by kidney failure in receiving qi.

Drynaria rhizome, Latin scientific name:DavalliamariesiiMooreexBakanother name: rhizoma Drynariae, rhizoma Coptidis, rhizoma Drynariae, radix seu caulis Kadsurae Heteroclitae, Nippon Feilong, caulis et folium Gaultheriae Yunnanensis, and herba Gei Falcati. The name of English:Drynariafortunei. All the plants of the order Filiformes and the family Drynariae can be harvested all year round, removed of silt, dried, or burned to remove fuzz (scales). The product is in the shape of flat and long strip, is bent, has branches, has dense dark brown to dark brown small scales on the surface, is soft like hair, is brown or dark brown by a singer, has convex or concave round leaf marks on both sides and the upper surface, and has few petiole residues and fibrous root residues. Light weight, crisp texture, easy breaking, reddish brown section, yellow dot vascular bundle, and arranged into ring. No smell, light taste, slightly astringent. The functional indications are as follows: tonify kidney, strengthen bone, heal wound and alleviate pain. Can be used for treating lumbago due to kidney deficiency, tinnitus, deafness, odontoseisis, traumatic injury, contusion, and fracture of bones and muscles; it is used externally to treat alopecia areata and vitiligo.

Spatholobus stem, Latin scientific name:Millettiareticuiatait is also called as "Papilionaceae" and is also called as "Leguminosae", angiosperma, dicotyledonae "and other plants. Evergreen woody vines, hairless, dark green new branches, and a plurality of triangular bud scales lodged at the base. Grow in forests with elevation below 1800 m. It is also distributed in southwest of Yunnan (Baoshan, Fengqing, Lincang, Gunn), Guangxi, and northeast of Burma. The efficacy and the effect are as follows: the root and stem of Yunnan caulis Spatholobi have effects of replenishing blood, promoting blood circulation, dredging meridian passage. 1. Effects on the hematopoietic system; 2. for blood coagulationFibrinolysis; 3. inhibiting heart and lowering blood pressure; 4. anti-cancer effect; 5. regulation of lipid metabolism.

Paniculate swallowwort root, famous nameCynanchumpaniculatum(Bunge)Kitagawa. Herba asari (Asarum heterotropoides (Fr.) Moore). Perennial upright herbs. The seed is in an oblong flowering period of 5-7 months, and the fruit period is 9-12 months. It mostly grows in the Yangpo grass bunch. Is distributed in provinces such as Heilongjiang, Jilin, Liaoning, Hebei, Henan, Shandong, inner Mongolia, Jiangsu, Zhejiang, Jiangxi, Fujian, Hubei, Hunan, Guangdong, Guangxi, Shaanxi, Gansu, Sichuan, Guizhou, Yunnan, etc. The radix Cynanchi Paniculati is dry root and rhizome of radix Cynanchi Paniculati of Cynanchum of Asclepiadaceae. Collected in autumn, removed impurities, dried in the shade, and has high medicinal value. Nature, flavor and meridian tropism: pungent and warm. It enters liver and stomach meridians. The functional indications are as follows: 1. can be used for treating various pains such as rheumatalgia, lumbago, traumatic injury pain, abdominal pain, toothache, etc. The paniculate swallowwort root has good effects of dispelling wind and relieving pain, and is widely used for various pains caused by rheumatism, congealing cold, qi stagnation and blood stasis. Also can be used for postoperative pain and cancer pain, and has certain analgesic effect. It can be used singly or combined with herbs related to syndrome. 2. It can be used for treating dermatoses such as eczema, rubella, and intractable tinea. The paniculate swallowwort root has the functions of dispelling wind and relieving itching. It can be used singly for oral administration or decocted for external washing, and can also be combined with dampness-heat-clearing herbs such as Ku Shen, Di Fu Zi and Bai Xian Pi. In addition, the paniculate swallowwort root can also relieve snake venom and treat venomous snake bite. It can be used with ban Bian Lian for oral or external use. 3. The book Jing: venomous, epidemic disease, evil and bad qi, warm malaria, marked by symptoms of easy death, crying, sadness and absentmindedness. 4. The bibliography: to replenish qi. 5. Preparation of raw herb Property: soak wine, remove wind-damp. 6. Simple herbs: it is indicated for traumatic injury, arthralgia and myalgia. 7. Lingnan herbal medicine collection book: it is indicated for abdominal distention and spasm of the muscles and joints in children. It is also indicated for epilepsy and dog bite. 8. Chinese medicine Zhi (records of materia Medica): it is indicated for all kinds of diseases such as acute gastroenteritis, abdominal pain, stomach-qi pain, food stagnation and cholera. 9. Nanjing folk herb (Nanjing folk medicine for treating AIDS): miao ethnic group, soaked in wine for gargling, can be used for treating toothache. 10. Guizhou folk prescription drug Collection: promote menstruation and blood circulation. It is indicated for red metrorrhagia and leukorrhagia. 11. Fujian folk herb (Fujian folk herb): replenishing qi, expelling the wind, strengthening the waist, and removing snake venom. 12. Guangzhou army 'handbook of Chinese herbal medicines for general use': dispel wind and alleviate pain, remove toxicity and relieve swelling, warm meridians and unblock collaterals. Treating poisonous snake biteInjury, rheumatic osteodynia, pain of heart and stomach, swelling and pain due to traumatic injury, herpes zoster, ascites due to cirrhosis, menoxenia, and dysmenorrhea. 13. Jilin Chinese herbal medicine: promoting urination, strengthening body, tranquilizing mind, relieving pain, dispelling cold, removing blood stasis, removing snake venom, dredging collaterals, and regulating blood circulation. It can be used for treating tinea pedis, edema, ascites, distention, and cold abdominal pain.

Red sage root, name of Chinese traditional medicine. Is Saviae Miltiorrhizae radix of LabiataeSalviamiltiorrhizaBge.Dried roots and rhizomes of (4). Collected in spring and autumn, removed of silt and dried. Distributed throughout most parts of the country. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Cassia twig, another name: willow osmanthus (academic name:CinnamomumcassiaPresl) Is Cinnamomum cassia Presl of LauraceaeCinnamomumcassiaPreslThe dried shoots. Harvesting in spring and summer, removing leaves, drying in the sun or slicing and drying in the sun, wherein the product is in a long cylindrical shape with multiple branches, the length of the product is 30-75 cm, and the diameter of the thick end of the product is 0.3-1 cm. The surface is reddish brown to brown, and has longitudinal ridge, fine wrinkle, leaf mark, branch mark, bud mark and skin hole point. Hard and brittle and easy to break. The thickness of the slice is 2-4 mm, the skin part of the cross section is reddish brown, the wood part is yellowish white to light yellowish brown, and the medulla part is slightly square. Has special fragrance, sweet and slightly pungent taste and stronger skin taste. Nature, flavor and meridian tropism: pungent and sweet with warm property enter lung, heart and bladder meridians. The efficacy is as follows: induce sweating to expel pathogenic factors from the muscles, warm and dredge meridians, strengthen yang and transform qi. The application comprises the following steps: 1. it is used for treating wind-cold exterior syndrome. It is pungent and warm in flavor, sweet and mild in flavor, and can relieve the sweat and muscles, and its sweating power is milder than Ma Huang, so it is indicated for wind-cold due to exterior excess or exterior deficiency. Treating: for exterior excess syndrome due to external wind-cold, it is often combined with Ma Huang to reinforce the action of dispersing wind-cold, such as Ma Huang Tang (treatise on Cold-induced disease); ② for exterior deficiency syndrome due to wind-cold with symptoms of sweating and floating and slow pulse, it is usually combined with Bai Shao to harmonize Ying and Wei, induce sweating and release muscles, such as Gui Zhi Tang (treatise on Cold-induced disease). 2. It is indicated for pain due to congealing cold and blood stagnation. Being pungent and warm, it can warm and unblock meridians, dispel cold to alleviate pain. Treating: for shoulder and arm arthralgia due to wind-cold-dampness, it is usually combined with Fu Zi and Sheng Jiang, such as Gui Zhi Fu Zi Tang (treatise on Cold-induced fever); ②For epigastric and abdominal cold pain due to deficiency-cold of middle energizer, it is often combined with Bai Shao, Shi Tang and gan Cao, for instance, Xiao Jian Zhong Tang (jin Kui Yao L ü e); ③ for amenorrhea and abdominal pain due to congealing cold and blood stasis or unblocking meridians, it is often combined with Dang Gui and Chuan Xiong, etc., such as Wen Jing Tang (jin Kui Yao L ü e); fourthly, chest yang deficiency and heart vessel obstruction due to obstruction of qi in the chest and heart pain are often combined with Zhi Shi and Xie Bai, such as Zhi Shi Xie Lang Gui Tang (jin Kui Yao L ü e); wu Shang Han Xin Ji and Mai Ji Dynasty, it is often combined with gan Cao and ren Shen, for instance, gan Cao Tang (treatise on Shang Han Lun). 3. It is indicated for phlegm-fluid retention and water retention. It is sweet and warm in property and can activate spleen to resolve dampness, and enter bladder meridian to warm yang and transform qi, so as to remove dampness, phlegm and retained fluid. Treating: for phlegm-fluid retention syndrome due to spleen yang deficiency, it is often combined with Fu Ling, Bai Zhu and gan Cao, i.e. Ling Gui Zhu gan Tang (jin Kui Yao L ü e); ② for edema and dysuria due to water retention in bladder, it is often combined with Fu Ling, Zhu Ling and ze Xie, for instance, Wu Ling san (treatise on Cold-induced diseases).

Cinnamon (latin scientific name:CinnamomumcassiaPresl) Also called cortex Cinnamomi, Concha Ostreae, cortex Cinnamomi Japonici, PINNANG Tree, and Chinese cortex Cinnamomi Japonici, is the dried bark of cortex Cinnamomi belonging to Lauraceae. The bark is aromatic and can be used as a spice, with a flavor similar to that of cinnamon produced from cinnamon of the srilanka type, but more pungent, less delicious than cinnamon and thicker than cinnamon. In North America, cinnamon powder is indiscriminately sold together with cinnamon from cinnamon of China. The cinnamon bark is peeled from the stems and branches, laid aside to dry, and rolled into rolls. Some varieties are scraped. The scraped ones were thin and bright reddish brown, and the non-scraped ones were thick and grey. The cinnamon powder is light reddish brown. Cinnamon produced in China has a slightly weaker flavor than those produced in Vietnam and Indonesia, and all the cinnamon, the Vietnam and the Indonesia have fragrance, sweet and spicy taste. Immature fruits of chinese cinnamon and oyster (c. laureiri) are attached to hard, crinkled, grayish brown cupped calyx, typically 11 cm long (0.4 inch, including the calyx pot); the diameter of the upper part is about 6 cm (0.25 inch), and the cinnamon bud is obtained by picking and drying the canula calyx. Has cinnamon-like fragrance and sweet and spicy taste of cinnamon bark, and can be used for flavoring food. The functional indications are as follows: tonify primordial yang, warm spleen and stomach, remove cold accumulation, and promote blood circulation. For decline of vital gate fire, cold limbs and slight pulse, yang exhaustion and collapse, abdominal pain and diarrhea, cold hernia and dolphin, cold pain in waist and knee, amenorrhea, deep rooted carbuncle, abscess and deficiencyThe floating yang is the upper heat and the lower cold. The book Jing: it mainly controls cough and dyspnea, stagnation of qi, obstruction of qi in the throat, vomiting and absorption, benefiting joint, invigorating spleen and replenishing qi. The bibliography: governing heart pain, hypochondriac wind, hypochondriac pain, warming tendons, promoting blood circulation, relieving restlessness and sweating. Mainly warm the middle energizer, promote the liver and lung qi, treat heart and abdomen cold and heat, cold diseases, cholera and spasm, headache, lumbago, saliva stopping, cough, nasal diseases: can induce abortion, strengthen bone, promote blood circulation, and regulate and dredge deficiency; xuan Zhi Bai Yao without any fear. Treatise on herb Property: the main treatment is as follows: the traditional Chinese medicine composition has the effects of killing three insects, mainly removing blood stasis, promoting menstruation, relieving obstruction of the moon, treating foot softening, arthralgia, numbness, retained afterbirth, removing cough, stagnation of qi, carbuncle and arthralgia, stopping cold air in the abdomen, stopping intolerable pain, mainly treating diarrhea and nasal polyp. Killing weed and wood toxins. Rihuazi Bencao: for all wind-qi, tonify five strains and seven impairments, unblock nine orifices, benefit joints, supplement essence, improve vision, warm waist and knee, suppress and remove wind-damp mass, treat heumatism and contracture of bone joints, reunite bones and grow muscles. Pearl sacs: to remove pathogenic wind in defense system and lower abdominal pain in autumn and winter. The medical inspiration is: tonify the lower energizer deficiency, treat cold-in shoulder, exterior deficiency and spontaneous sweating. The main treatment secret essences: seep and purge, quench thirst. The method of medication administration: to counteract cold pathogen, treat the rushing-fish. Wang Hao Gu: to supplement the deficiency of the vital gate, to replenish fire and eliminate yin. Compendium (compendium): it is indicated for wind acute urticaria, excessive yin failing to circulate blood, dysentery and convulsions due to cold arthralgia. For yang deficiency and blood loss, the interior-supporting abscess, deep-rooted carbuncle and acne can induce blood, resolve sweating and suppuration and remove the toxin of snake and pit viper.

Radix aucklandiae (RadixAucklandiae) Is a generic name of saussurea lappa and common vladimiria root of Compositae. Saussurea lappa (academic name:Saussureacostus) Also named as radix aucklandiae, Mirabilitum, radix Aristolochice, radix aucklandiae, and radix Aristolochice, belonging to Compositae family saussurea genus. Common vladimiria root (academic name:Vladimiriasouliei) Is a plant of the genus Sichuan wood of the family Compositae, which is a specific plant of China. The elecampane is distributed in Sichuan, Yunnan and Tibet of continental China, mostly grows in high-mountain grasslands and shrubs, is a wild plant, and is not artificially introduced and cultivated. The rhizomes of both plants are important Chinese herbal medicines. Nature and taste: pungent taste; bitter; and (4) temperature. (I) Ben Jing: pungent and warm in flavor. ② Ben Tang Ye Cao: hot in smell, pungent and bitter in taste, and non-toxic. Meridian tropism: invigorating spleen; the large intestine and triple energizer meridians. (supplement to Yi of materia Medica): to move the liver meridian. ② Lei Gong processing medicine property solution: entering heart, lung, liver, spleen, stomach and shouldercysti-Liu Jing. The efficacy is mainly as follows: the efficacy is as follows: promoting qi circulation, relieving pain, strengthening spleen and promoting digestion are mainly used: promoting qi circulation and relieving pain; to regulate the middle energizer and remove food stagnation. Hypochondriac distention in the main cell is satisfied; abdominal distending pain; belching, vomiting and diarrhea; severe after dysentery. Can be used for treating chest and abdominal pain, dysentery, tenesmus, dyspepsia, and anorexia; the middle-jiao energy is not saved; sudden deafness; biting by snake and insect; toothache. 1. Gastric and abdominal fullness or pain, belching, nausea and vomiting due to qi stagnation of the spleen and stomach. 2. Chest oppression, abdominal distension, poor appetite and loose stool due to damp-turbidity obstruction in the middle energizer. 3. Cough and dyspnea due to phlegm-dampness obstructing the lung. 4. Pathogenic qi, virulent pestilence, epidemic warm and foggy body, strengthening will, mainly stranguria and loving body fluid. For a long time, the nightmare is not dreaming. (Ben Jing) 5. Disinfection, killing ghost essence, warm malaria, venomous, qi deficiency, cold muscles, and inducing essence. ("Bie Lu")

The academic name of Galla chinensis (Chinese gall)RhuschinensisMill.) The gall is prepared by that the female aphid of the Aphis angularis or the female aphid of the Eyelophora ovalicata of the Homoptera family parasitizes on the tender leaves or leafstalks of the Rhus chinensis and other plants of the same genus of the Anacardiaceae family, stabs to generate a sac-shaped poly-organism gall, and is baked and dried. In addition, the Chinese gall is also a medicinal material and can treat various diseases. The pharmacological action is as follows: 1. the Chinese gall contains tannic acid and has the function of precipitating protein, and after the skin ulcer surface and the mucous membrane are contacted with the Chinese gall, tissue protein is coagulated to form a protective film to play the role of astringency, and meanwhile, small blood vessels are compressed and contracted to coagulate blood to play a role of stopping bleeding. The protein of gland cell is coagulated to cause secretion inhibition, so that mucous membrane is dried, and the protein of nerve ending is precipitated to present weak local anesthesia phenomenon. The tannic acid contained in Galla chinensis has no influence on normal small intestine movement, but can relieve intestinal inflammation due to its astringent effect, so as to stop diarrhea. 2. The antibacterial effect in vitro test shows that: the gallnut decoction has obvious bacteriostatic and bactericidal effects on staphylococcus aureus, beta hemolytic streptococcus, pneumococcus, pseudomonas aeruginosa, shigella dysenteriae, bacillus anthracis, diphtheria bacillus, escherichia coli, typhoid fever, paratyphoid fever bacillus and the like. The gallnut liquid after extracting tannic acid with ether still has the bacteriostatic action. However, the Chinese gall decoction has no antibacterial effect. 3. Other effects of Galla chinensis decoction have inhibitory effect on influenza type A PR8 strain virus inoculated in chick embryo, and the effect may be combined with the effectThe tannins contained therein are involved. In vitro spermicidal test shows that: 10% Galla chinensis glycerol solution (1: 1) has spermicidal effect. Tannic acid forms insoluble compounds with several metals, alkaloids or glycosides and thus can be used as antidote.

Berchemia lineate is a general name of plant and traditional Chinese medicine. Latin learning name:Berchemialineata(L.)DC.the plant of berchemia lineata is rhamnaceae rattan or bush. Tender nuclei are yellow green, dense, short and soft. The root of the variety is brown like iron because of the trametes hair, and gold like gold because of the yellow color of the xylem. Generally growing in low-altitude mountains, dwarf forests, roadside, sloping fields and hills. The herba Berchemiae Lineatae is caulis Seu folium Ampelopsis Brevipedunculatae or root of Rhamnaceae plant herba Berchemiae Lineatae and ramulus Uncariae cum uncis of the same genus. From Lingnan medicine collection, early autumn in the end of summer and before pregnancy, cutting tender stem and leaf, removing impurities, cutting into pieces, and fresh or sun drying; after autumn, the root is picked, and the fresh or sliced root is dried in the sun and used as the medicine. Has the functions of eliminating swelling, detoxicating, stopping bleeding, relieving pain, dispelling wind, eliminating dampness, etc. Distributed in various parts of the south of China. [ PROPERTIES AND FLAVOUR ] bitter; slightly astringent; ping (meridian tropism) heart; the lung meridian (indications) can relieve swelling and remove toxicity; hemostasis and analgesia; dispelling wind and eliminating dampness. Mainly carbuncle, deep-rooted carbuncle and furunculosis; cough with hemoptysis; bleeding of the digestive tract; traumatic injury; scalding; rheumatic bone pain; toothache due to wind-fire evil.

Lignum sappan (lignum sappan) (III)CaesalpiniasappanLinn) A plant of the genus Caesalpinia of the family Caesalpiniaceae, flowering phase 5-10 months; fruit stage 7 months to next 3 months. The small arbor is as high as 6 m, has thorns, and is slightly soft except old branches, under leaves and pods; the skin pores on the branches are dense and prominent. The length of the second return pinnate compound leaf is 30-45 cm; pinna 7-13[1 ]]The pair is paired, the length is 8-12 cm, the leaflets are 10-17 pairs, the closely adjacent leaflets have no stems, the leaflet paper is long and long round to long round rhombus, the length is 1-2 cm, the width is 5-7 mm, the tip is slightly short, the base is inclined, and the leaflet paper is attached to the pinna axis at an oblique angle; the lateral veins are fine and visible on both sides, linking them to the vicinity of the edges. The conifer grows from the top or the axilla and has the same length as the leaves; big bract, needle-shaped, early falling; the pedicel is 15 mm long and is fine and soft; the receptacle is shallow and bell-shaped; sepals 5, slightly different, the lower sepals are larger than the others and are in a pocket shape; the petals are yellow, wide and inverted egg-shaped, the length is about 9 mm, and the uppermost basal part is pink and provided with a handle; the stamen is slightly extended out and the lower part of the filament is densely covered with soft hair(ii) a The ovary is made of gray villi with handle, the style is slender, the quilt hair is cut off, and the stigma is flat. The pod is woody, is slightly flattened, is approximately in the shape of an oblong to an oblong inverted oval, is about 7 cm long, 3.5-4 cm wide, has a slightly narrow base, has a tip which is obliquely truncated, has a hard beak which is bent outwards or warped upwards at the upper corner, does not crack, is reddish brown and has luster; 3-4 seeds, long round, slightly flat and light brown. [ PROPERTIES, WESTERN AND CHANNEL FENCH ] is sweet, salty and neutral. It enters heart, liver and spleen meridians. [ FUNCTIONS ] can promote blood circulation, dispel blood stasis, and relieve swelling and pain. Can be used for treating amenorrhea, dysmenorrhea, puerperal stagnation, thoracico-abdominal pain, and traumatic swelling and pain.

Huanggen, the name of Chinese medicine. Is a flower of south mountain of RubiaceaePrismatomeristetrandra(Roxb.)K.Schum.The root of (2). Has the effects of cooling blood, stopping bleeding, promoting diuresis, removing jaundice, removing blood stasis and strengthening tendons. Can be used for treating gingival hemorrhage, anemia, hepatitis, rheumatic arthritis, traumatic injury, and urinary tract infection.

Dodder seed (academic name:CuscutachinensisLam.) The alias name is zenzhen, parasitism of beans, Hades and Haemangwang, shredded yellow tobacco, fibraurea stem, spatholobus stem, golden rattan and the like. Annual parasitic herbs. Stem tangle, yellow, slender, and leafless. The inflorescence grows laterally, and small flowers or multiple clusters grow into small umbrella-shaped or small cluster umbrella inflorescences; the bract and the small bract are small and are scaly; the flower stalks are slightly thick; calyx shaped, the middle part below the calyx is connected, and the lobe is triangular; the corolla is white and pot-shaped; the slight lower part of the dehiscent flower crest of the stamen; flake obround; the ovary is nearly spherical, and the style is 2. The capsule is spherical and is almost completely surrounded by the lodged corolla. 2-49 seeds, light brown, oval, about 1 mm long, rough surface. Dodder is a good medicine for tonifying kidney, liver and spleen, and is mainly clinically applied to kidney yin-yang deficiency syndromes such as lumbago due to kidney deficiency, impotence, spermatorrhea, frequent micturition, infertility due to cold womb, dark eyes and loose stool. Dodder seed, sweet and warm in nature, entering kidney, liver and spleen meridians, has the effects of nourishing liver and kidney, securing essence, reducing urination, preventing abortion, improving eyesight and stopping diarrhea, and is listed as the top grade since Shen nong Ben Cao Jing. Sweet flavor has the nourishing effect, is sweet, pungent and slightly warm, can neutralize intrinsic qi, can tonify yang and yin, and has the characteristics of warmness without dryness and tonification without stagnation. Secure essence and prevent miscarriage and has the same effect as sex hormone. The traditional Chinese medicine considers that the kidney is the congenital foundation and internally integrates primordial yin and primordial yang, which are the root of human reproductive development and the source of visceral function activityAnd (4) power.

Hispid fig belongs to the family of Moraceae, is not a peach widely distributed in mountains mainly in Hakka area in Meizhou, east Guangdong, and naturally grows in the valley of deep mountains, because leaves grow like hispid fingers, leaves grow fine hair, and fruits mature like hispid fig. Hispid fig, Latin name:1FicussimplicissimaLour.F.hirtaVahlvar.palmatiloba(Merr.) Chunthe soup is similar to the fragrance of coconut, and is popular with people. The pharmacological action is as follows: the radix fici simplicissimae decoction, the ethanol extract and the water extract of the residue after ethanol reflux are respectively infused into mice to have obvious cough relieving effect on the cough caused by ammonia water spray. The test tube test has good bacteriostatic action on staphylococcus aureus and streptococcus A. [ CHEMICAL COMPONENTS OF CHINESE MEDICINE ] contains amino acids, saccharides, steroids, and coumarins. [ EFFECT ] invigorating spleen and tonifying lung; promoting qi circulation and removing dampness; muscles and tendons relaxing and activating [ family genus classification ] Moraceae [ indications ] Ficus simplicissima lour has the effects of invigorating spleen and tonifying lung, promoting qi circulation and removing dampness, and relaxing and activating tendons, and is commonly used by Chinese medicine or minority doctors in Lingnan region for treating spleen deficiency and edema, anorexia and weakness, phthisis cough, night sweat, leukorrhagia, puerperal agalactia, irregular menstruation, rheumatalgia, edema, etc. [ COLLECTING AND STORAGE ] can be harvested all the year round, cleaned, sliced and dried in the sun. [ CHEN ] the five fingers and the five paws are named according to their leaf shapes; "Maotao" refers to the fruit of wild peach; "milk" means its juice. It is named as Wu Jia Pi and Tu Huang Qi because it has similar action to Wu Jia and Huang Qi. Generally, the medicinal material is used in Guangdong regions to cook soup with fresh meat such as spareribs and the like, and has the functions of relieving summer heat and resolving dampness; radix fici simplicissimae is a common herb in Lingnan, is prepared from root of Ficus benjamina of Ficus of Moraceae, has mild nature, sweet and pungent taste, has effects of invigorating spleen, tonifying lung, promoting diuresis and relaxing muscles and tendons, and can be used for treating spleen deficiency, edema, anorexia, weakness, cough due to pulmonary tuberculosis, night sweat, rheumatalgia, puerperal agalactia, etc. In addition, hispid fig is a plant with the same source of food and medicine and is used for cooking soup in Guangdong region. In recent years, the Ficus Simplicissima lour as a precious plant resource draws high attention of pharmaceutical workers, the research on chemical components, pharmacological activity and other aspects is deepened, and the psoralen is proved to be one of the main active components of the Ficus Simplicissima lour,has antibacterial, antiviral, anticoagulant, antitumor, and immunoregulatory effects. Ficus simplicissima lour, also known as Ficus benjamina and Ficus benjamina, is called "Wuzhuanglong" in Guangdong from Guangzhou plant essences, also known as Ficus simplicissima lour, Wuzhuang milk, radix astragali, etc. The plant shape, shrub or arbour, the whole stem, pericarp and leaves contain emulsion, and the root and bark have fragrance. The components are as follows: contains organic acid, amino acid, triterpene, alkaloid, and coumarin. Recorded in the Chinese pharmacopoeia, the hispid fig has pungent and sweet taste, mild nature and mild temperature, and the function: has effects of invigorating qi, tonifying deficiency, activating qi-flowing, resolving stagnation, strengthening tendons, activating collaterals, invigorating spleen, eliminating dampness, relieving cough, and eliminating phlegm. The hispid fig plant is widely distributed in mountain areas in North Guangdong and naturally grows in deep mountains and valleys, leaves of the hispid fig plant are like the hispid fig, the leaves are fine and have fine hair, fruits of the hispid fig plant can be like the hispid fig when mature, the smell is pungent and sweet, the nature is mild, the fragrance overflows, the leaves are generally collected and dried, a small part of the leaves are taken firstly and cleaned with clear water when being eaten, the leaves are soaked in cold water for fifteen minutes to cook soup with pork ribs, pigeons and the like, the soup is cooked slowly with small fire for the longer time, the open fire is used, the effect is better, and the soup cooked has the fragrance of coconut milk. The product has effects in calming liver, improving eyesight, nourishing yin, lowering fire, invigorating spleen, promoting appetite, promoting salivation, eliminating dampness, removing food stagnation, clearing liver-fire, and moistening lung. The food is suitable for all people regardless of spring, summer, autumn and winter.

Radix Polygalae Fallacis (Latin school name:PolygalafallaxHemsl) Is shrub or small tree of Polygala of Polygalaceae, and has a height of 3 m; the root is thick, the lamina membranacea is thick, the single leaf grows alternately, the leaf surface is dark green, the back is light green, the head of the raceme or axillary, the petal is yellow, the keel helmet shape, the cockscomb shaped appendage has a handle, and the anther is egg-shaped; the ovary is round, the capsule has a shape of broad inverted heart to a round shape, the green yellow, the seed is round, the seed is Fujian helmet shape, and the flowering and fruit period is 5-10 months. The species peculiar to China, which are born in the mountain slope sparse forest or the valley forest. They are distributed in Guangxi, Guangdong and Jiangxi provinces of Hunan provinces. Sweet, slightly bitter and neutral in nature and taste. Has the functions of invigorating qi and blood, invigorating spleen, promoting diuresis, promoting blood circulation and regulating menstruation. Can be used for treating asthenia, soreness of waist and knees, traumatic injury, icterohepatitis, nephritis edema, metroptosis, leukorrhagia, and menoxenia.

Mirabilite, the name of traditional Chinese medicine. Is sulfate mineral MirabilitumNitre, and crystal prepared by processing and refining. Sodium sulfate (Na) mainly containing water₂SO₄·10H₂O). The distribution is distributed in most areas of the country. Has the effects of relaxing bowels with purgative, moistening dryness, softening hard masses, clearing away fire and relieving swelling. It is often used for treating excess heat accumulation, abdominal distention and pain, constipation, and intestinal abscess with swelling and pain; it is indicated for acute mastitis, hemorrhoid with swelling and pain.

The following are the beneficial effects of the invention:

the traditional Chinese medicines adopted by the invention are common, but contain a plurality of pharmacologies which are combined together, and are very symptomatic for treating the vitiligo. The precious herbs are not always good herbs with all functions, but the general herbs are not good enough, and most important thing is to understand that the effect of eliminating the disease can be achieved by selecting herbs with proper symptoms. In the formula of the invention, the psoralea fruit, the drynaria rhizome, the suberect spatholobus stem, the paniculate swallowwort root and the red sage root are monarch drugs; berchemia lineate, sappan wood, radix scutellariae, semen cuscutae, hispid fig and polygala fallax hemsl are used as ministerial drugs; ramulus Cinnamomi, cortex Cinnamomi, radix aucklandiae, Galla chinensis and Natrii sulfas as adjuvant drugs. The medicines are used together to tonify liver and kidney, invigorate qi and blood, relieve pain and itch, promote blood circulation and remove stagnancy, and increase the density of melanocytes in epidermis and the activity of tyrosinase in the melanocytes, thereby promoting the biochemical synthesis and operation of melanin, and enabling skin color to recover to normal so as to achieve the treatment purpose. The preparation process of the traditional Chinese medicine external medicament for treating leucoderma is particularly important, and the fructus psoraleae, the rhizoma drynariae, the caulis spatholobi, the paniculate swallowwort root, the root of red-rooted salvia, the cassia twig, the cinnamon, the elecampane, the gallnut, the berchemia lineate, the sappan wood, the radix scutellariae, the semen cuscutae, the hispid fig root and the radix polygalae fallax are firstly crushed and sieved by a sieve with 10 meshes to obtain coarse powder for later use; mixing fructus Psoraleae coarse powder, rhizoma Drynariae coarse powder, caulis Spatholobi coarse powder, radix Cynanchi Paniculati coarse powder, Saviae Miltiorrhizae radix coarse powder, radix Berchemiae Giraldianae coarse powder, lignum sappan coarse powder, radix Scutellariae coarse powder, semen Cuscutae coarse powder, hispid Fig coarse powder and radix Polygalae Fallacis coarse powder, placing into a container, adding distilled liquor (1800 ml per 150g fructus Psoraleae), sealing and soaking for 30 days, collecting supernatant, and filtering to obtain filtrate; secondly, adding the cassia twig coarse powder, the cinnamon coarse powder, the costustoot coarse powder and the gallnut coarse powder into the filtrate, uniformly stirring, sealing, standing for 7 days, and taking supernatant for later use; finally, mirabilite is added into the supernatant, the mixture is stirred evenly and filtered, and the obtained filtrate can be used as the traditional Chinese medicine external preparation for treating leucoderma. The fructus psoraleae coarse powder, the rhizoma drynariae coarse powder, the caulis spatholobi coarse powder, the cynanchum paniculatum coarse powder, the salvia miltiorrhiza coarse powder, the berchemia lineata coarse powder, the sappan wood coarse powder, the radix astragali coarse powder, the semen cuscutae coarse powder, the hispid fig coarse powder and the radix polygalae fallax coarse powder are mixed uniformly, the mixture is placed in a container, distilled liquor is added, 1800ml of distilled liquor is required to be added for every 150g of fructus psoraleae, the distilled liquor is sealed and soaked for 30 days, effective active ingredients of monarch drug and ministerial drug are extracted, the curative effect of the monarch drug is improved under the auxiliary action of the ministerial drug, then the. Through tests, the traditional Chinese medicine external preparation prepared by the preparation method has a better treatment effect than the traditional Chinese medicine external preparation prepared by putting all the raw materials into distilled liquor together for soaking and extracting, the pigmentation is faster than 4 days, and the traditional Chinese medicine external preparation is respectively used by 30 volunteers, the traditional Chinese medicine external preparation has no recurrence phenomenon, and the traditional Chinese medicine external preparation prepared by putting all the raw materials into distilled liquor together for soaking and extracting has the recurrence phenomenon of 5 volunteers.

Detailed Description

In order to describe the present invention in more detail, the present invention will be further described with reference to the following examples.

Example 1

The traditional Chinese medicine external preparation for treating leucoderma is prepared by the following preparation steps:

(1) taking 150 parts of fructus psoraleae, 100 parts of rhizoma drynariae, 20 parts of caulis spatholobi, 20 parts of paniculate swallowwort root, 20 parts of salvia miltiorrhiza, 20 parts of cassia twig, 20 parts of cinnamon, 20 parts of elecampane, 20 parts of gallnut, 25 parts of berchemia lineate, 20 parts of sappan wood, 20 parts of radix scutellariae, 20 parts of semen cuscutae, 20 parts of hispid fig root, 20 parts of radix polygalae fallax hemsl and 20 parts of mirabilite, crushing fructus psoraleae, rhizoma drynariae, caulis spatholobi, paniculate swallowwort root, salvia miltiorrhiza, cassia twig, cinnamon, elecampane, gallnut, berberis, berchemia lineate, sappan wood, radix scutellariae, semen cuscutae, radix fici;

(2) uniformly mixing fructus psoraleae coarse powder, rhizoma drynariae coarse powder, caulis spatholobi coarse powder, paniculate swallowwort root coarse powder, salvia miltiorrhiza coarse powder, berchemia lineata, sappan wood coarse powder, radix scutellariae coarse powder, semen cuscutae coarse powder, hispid fig coarse powder and radix polygalae fallax coarse powder, putting into a container, adding 1500-2100 parts of 50% distilled grain wine, sealing and soaking for 30 days, taking supernate, filtering, and keeping filtrate for later use;

(3) adding ramulus Cinnamomi coarse powder, cortex Cinnamomi coarse powder, radix aucklandiae coarse powder and Galla chinensis coarse powder into the filtrate, stirring, sealing, standing for 7 days, and collecting supernatant;

(4) adding Natrii sulfas into the supernatant, stirring, adding 50% rice wine to 1000ml, mixing, and filtering.

Example 2

The traditional Chinese medicine external preparation for treating leucoderma is prepared by the following preparation steps:

(1) taking 150.0g of fructus psoraleae, 100.0g of rhizoma drynariae, 25.0g of caulis spatholobi, 25.0g of paniculate swallowwort root, 25.0g of salvia miltiorrhiza, 25.0g of cassia twig, 25.0g of cinnamon, 25.0g of costus root, 25.0g of Chinese gall, 30.0g of berchemia lineate, 25.0g of sappan wood, 25.0g of radix scutellariae, 25.0g of dodder, 25.0g of hispid fig root, 25.0g of radix polygalae fallax flower and 20.0g of mirabilite, and respectively crushing fructus psoraleae, rhizoma drynariae, caulis spatholobi, paniculate swallowwort root, salvia miltiorrhiza, cassia twig, cinnamon, costustoot, Chinese gall, berchemia lineate, sappan wood, radix scutellariae, semen cuscutae, radix fici simplicis and radix polygalae fal;

(2) mixing fructus Psoraleae coarse powder, rhizoma Drynariae coarse powder, caulis Spatholobi coarse powder, radix Cynanchi Paniculati coarse powder, Saviae Miltiorrhizae radix coarse powder, radix berchemiae lineatae coarse powder, lignum sappan coarse powder, radix Scutellariae coarse powder, semen Cuscutae coarse powder, hispid Fig coarse powder and radix Polygalae Fallacis coarse powder, placing into a container, adding 1800ml of distilled rice wine with alcohol concentration of 50%, sealing and soaking for 30 days, collecting supernatant, filtering, and collecting filtrate;

(3) adding ramulus Cinnamomi coarse powder, cortex Cinnamomi coarse powder, radix aucklandiae coarse powder and Galla chinensis coarse powder into the filtrate, stirring, sealing, standing for 7 days, and collecting supernatant;

(4) adding Natrii sulfas into the supernatant, stirring, and filtering to obtain the final product.

Example 3

The traditional Chinese medicine external preparation for treating leucoderma is prepared by the following preparation steps:

(1) taking 180 parts of fructus psoraleae, 130 parts of rhizoma drynariae, 25 parts of caulis spatholobi, 25 parts of paniculate swallowwort root, 25 parts of salvia miltiorrhiza, 25 parts of cassia twig, 25 parts of cinnamon, 25 parts of costus root, 25 parts of Chinese gall, 30 parts of berchemia lineate, 25 parts of sappan wood, 25 parts of radix astragali, 25 parts of semen cuscutae, 25 parts of hispid fig root, 25 parts of polygala fallaxa and 25 parts of mirabilite, respectively crushing fructus psoraleae, rhizoma drynariae, caulis spatholobi, paniculate swallowwort root, salvia miltiorrhiza, cassia twig, cinnamon, costus root, Chinese gall, berberis tinctoria, sappan wood, radix astragali, semen cuscutae, hispid fig root and radix polygala fallaxa;

(2) uniformly mixing fructus psoraleae coarse powder, rhizoma drynariae coarse powder, caulis spatholobi coarse powder, paniculate swallowwort root coarse powder, salvia miltiorrhiza coarse powder, berchemia lineata, sappan wood coarse powder, radix scutellariae coarse powder, semen cuscutae coarse powder, hispid fig coarse powder and radix polygalae fallax coarse powder, putting into a container, adding 1500-2100 parts of 50% distilled liquor, sealing and soaking for 30 days, taking supernate and filtering to obtain filtrate for later use;

(3) adding ramulus Cinnamomi coarse powder, cortex Cinnamomi coarse powder, radix aucklandiae coarse powder and Galla chinensis coarse powder into the filtrate, stirring, sealing, standing for 7 days, and collecting supernatant;

(4) adding Natrii sulfas into the supernatant, stirring, and filtering to obtain the final product.

Example 4

The traditional Chinese medicine external preparation for treating leucoderma is prepared by the following preparation steps:

(1) taking 200 parts of fructus psoraleae, 150 parts of rhizoma drynariae, 30 parts of caulis spatholobi, 30 parts of paniculate swallowwort root, 30 parts of salvia miltiorrhiza, 30 parts of cassia twig, 30 parts of cinnamon, 30 parts of costustoot, 30 parts of Chinese gall, 35 parts of berchemia lineate, 30 parts of sappan wood, 20-30 parts of radix astragali, 30 parts of semen cuscutae, 30 parts of hispid fig root, 30 parts of polygala fallaxa herb and 30 parts of mirabilite, crushing the fructus psoraleae, the rhizoma drynariae, the caulis spatholobi, the paniculate swallowwort root, the salvia miltiorrhiza, the cassia twig, the cinnamon, the elecampane, the gallnut, the berchemia lineate, the sappan wood, the radix astragali, the semen cuscutae, the hispid fig;

(2) uniformly mixing fructus psoraleae coarse powder, rhizoma drynariae coarse powder, caulis spatholobi coarse powder, paniculate swallowwort root coarse powder, salvia miltiorrhiza coarse powder, berchemia lineata, sappan wood coarse powder, radix scutellariae coarse powder, semen cuscutae coarse powder, hispid fig coarse powder and radix polygalae fallax coarse powder, putting into a container, adding 1500-2100 parts of 50% distilled grain wine, sealing and soaking for 30 days, taking supernate, filtering, and keeping filtrate for later use;

(3) adding ramulus Cinnamomi coarse powder, cortex Cinnamomi coarse powder, radix aucklandiae coarse powder and Galla chinensis coarse powder into the filtrate, stirring, sealing, standing for 7 days, and collecting supernatant;

(4) adding Natrii sulfas into the supernatant, stirring, and filtering to obtain the final product.

The traditional Chinese medicine external preparation obtained in the embodiment is provided for 30 volunteers for use, and the 30 volunteers have more than half a year of vitiligo; 30 volunteers rub the affected part with the Chinese medicinal composition twice a day, once in the morning and at night, 25 of the volunteers rub the waist, recover the pigment after 25 days, 5 of the volunteers rub the waist, recover the pigment after 10 days, recover the pigment after one month, and no relapse occurs in about one and a half years after continuous rubbing for 35 days.

Typical cases are:

in case 1, a certain person in Hao, a woman in Ladies, a person in 18 years old, Guangxi Nanning, a patient with a history of 1 year, and a leukoplakia on the neck and hands were rubbed on the affected part with the preparation obtained in example 2, at the same time, the waist was rubbed twice a day, once in the morning and at night, different degrees of pigmentation appeared after one week after rubbing, the pigment was recovered after 25 days, and no recurrence was observed for more than one year after continuous rubbing for one month.

Case 2, a certain horse, male, 24 years old, Guangxi Nanning, 2 years old, with a history of irregular leucoderma flaked in the neck and back, the preparation obtained in example 2 was rubbed on the affected part, at the same time, the waist was rubbed twice a day, once in the morning and at night, after one week after rubbing, pigmentation appeared to different degrees, after 30 days, the pigment was recovered, and after 35 days of continuous rubbing, no recurrence was seen in the last two years.

The above description is not intended to limit the present invention, and the present invention is not limited to the above examples, and those skilled in the art should understand that they can make various changes, modifications, additions and substitutions within the spirit and scope of the present invention.

Claims (1)

1. A preparation method of a traditional Chinese medicine external preparation for treating leucoderma is characterized by comprising the following steps: the preparation process comprises the following steps:

(1) taking 150-200 parts of fructus psoraleae, 100-150 parts of rhizoma drynariae, 20-30 parts of caulis spatholobi, 20-30 parts of paniculate swallowwort root, 20-30 parts of salvia miltiorrhiza, 20-30 parts of cassia twig, 20-30 parts of cinnamon, 20-30 parts of elecampane, 20-30 parts of Chinese gall, 25-35 parts of berchemia lineate, 20-30 parts of sappan wood, 20-30 parts of radix scutellariae, 20-30 parts of semen cuscutae, 20-30 parts of hispid fig root, 20-30 parts of radix polygalae fallax flower and 20-30 parts of radix polygalae fallax flower, crushing the fructus psoraleae, the rhizoma drynariae, the caulis spatholobi, the paniculate swallowwort root, the salvia miltiorrhiza, the cassia twig, the cinnamon, the radix aucklandiae, the Chinese gall, the berchemia lineate, the sappan wood, the radix astragali, the semen cuscutae, the radix; in the formula, the psoralea fruit, the drynaria rhizome, the suberect spatholobus stem, the paniculate swallowwort root and the danshen root are monarch drugs; berchemia lineate, sappan wood, radix scutellariae, semen cuscutae, hispid fig and polygala fallax hemsl are used as ministerial drugs; ramulus Cinnamomi, cortex Cinnamomi, radix aucklandiae, Galla chinensis and Natrii sulfas as adjuvant drugs;

(2) uniformly mixing fructus psoraleae coarse powder, rhizoma drynariae coarse powder, caulis spatholobi coarse powder, paniculate swallowwort root coarse powder, salvia miltiorrhiza coarse powder, berchemia lineata coarse powder, sappan wood coarse powder, radix scutellariae coarse powder, semen cuscutae coarse powder, hispid fig coarse powder and radix polygalae fallax coarse powder, putting into a container, adding 1500-2100 parts of distilled grain wine, sealing and soaking for 30 days, taking supernate and filtering, and keeping filtrate for later use; the distilled grain wine is fermented by grain with alcohol concentration of more than 50% or potato;

(3) adding ramulus Cinnamomi coarse powder, cortex Cinnamomi coarse powder, radix aucklandiae coarse powder and Galla chinensis coarse powder into the filtrate, stirring, sealing, standing for 7 days, and collecting supernatant;

(4) adding Natrii sulfas into the supernatant, stirring, and filtering.