CN103655999B - Medicine of control bird flu and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine preventing and treating bird flu, it is that step obtains by the following method: one, take raw material and take raw material by following proportion by weight: the Radix Astragali 71 ~ 87 parts, Herba Taraxaci 71 ~ 87 parts, Herba Scutellariae Barbatae 71 ~ 87 parts, 29 ~ 35 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 87 parts, Radix Ginseng 71 ~ 87 parts, the Folium Ligustri Lucidi 72 ~ 87 parts, Folium Isatidis 72 ~ 87 parts, Herba Equiseti Hiemalis 71 ~ 87 parts, Ramulus Uncariae Cum Uncis 72 ~ 88 parts, Rhizoma Nelumbinis 86 ~ 106 parts, Fructus Rosae Laevigatae 71 ~ 87 parts, Herba Menthae 72 ~ 88 parts; Two, the raw material pulverizing will claimed, mix homogeneously, obtains the medicine preventing and treating bird flu.It uses medicine of the present invention can improve immunity for the poultry such as chicken, duck not infecting avian influenza in advance, has good preventive effect to bird flu; Good therapeutical effect is had for the poultry suffering from avian influenza symptom.

Description

Medicine of control bird flu and preparation method thereof

Technical field

The present invention relates to medicine of a kind of fowl epidemic diseases control and preparation method thereof, particularly a kind of have medicine of obvious preventive and therapeutic action and preparation method thereof to bird flu.

Background technology

Bird flu is the abbreviation of avian influenza, and it is the infectious disease caused by the hypotype of influenza A virus, is decided to be category-A infectious disease by International Office of Epizootics, also known as fowl plague or European fowl plague.Be not only chicken, some other poultry and wild bird can infect bird flu, and the terrestrial birds such as such as turkey, pigeon, guinea fowl, Carnis Coturnicis japonicae, Psittacula alexandri fasciata all can infection morbidity, but with turkey and chicken susceptible the most, M & M is all very high; The aquatic bird such as duck and goose also easy infection, and poison or inapparent infection can be with, sometimes also can mortality.And it is as higher in duckling, its mortality rate of young goose for aquatic bird.By the type of pathogen, bird flu can be divided into highly pathogenic, low pathogenicity and non-pathogenic three major types.Non-pathogenic bird flu can not cause manifest symptom, only makes the avian body interior generation antiviral antibody of catching an illness.Low pathogenicity bird flu can make birds occur slight respiratory symptom, and appetite reduces, egg production declines, and occurs fragmentary dead.High pathogenic avian influenza is the most serious, and M & M is high, and the chicken group of infection usually " is annihilated ".

Bird flu virus (AIV) belongs to influenza A virus, and influenza virus belongs to the orthomyxovirus section of RNA viruses, point first, second, the third 3 types.Wherein influenza A virus is mainly in birds, some hypotypes also can infected pigs, horse, various mammal and the mankind such as sea dog and whale; B-mode and influenza virus C then sees the infection of sea dog and pig respectively.Influenza A virus is pleomorphism, and wherein spherical diameter 80 ~ 120nm, has cyst membrane.Bird flu virus, according to its adventitia hemagglutinin (H)/and the difference of neuraminidase (N) protein antigenicity, can be divided into 16 H hypotypes (H1 ~ H16) and 9 N hypotypes (N1 ~ N9) at present.

Bird flu is found over more than 100 year, and the mankind do not grasp effective prevention and therapy method.At present for avian influenza, people mainly take following measures to tackle:

1. slaughter the sick fowl (chicken, duck etc.) of infection.Timeliness coverage infects or morbidity epidemic situation, and the state of viral circulation in environment, and taking as early as possible is slaughtered, stop business etc. eliminates the measure of propagating between the source of infection, blocking virus fowl, and Dead birds must burn or buried.Although this processing method can be stretched to a certain degree controlling avian influenza, needing the processing cost costed a lot of money, and serious economic loss can be caused to raiser.

2. immunity inoculation.Avian influenza virus vaccine inoculation is the first-selected measure of current mankind flu-prevention, and particularly will carry out primary immune response in the season occurred frequently of bird flu every 3 ~ 4 months, the epidemic prevention of these two kinds of avian influenza vaccines takes interval and carries out for 10 days.But, because influenza virus serotype is numerous, once the antigenicity of influenza virus vaccine strain and epidemic strain is not mated, will vaccine failure be caused, corresponding protection cannot be provided; Speed simultaneously due to influenza virus variation is very fast, and the speed of vaccine research and development lags behind the speed of virus variation, and after new epidemic strain occurs, the preparation of its corresponding vaccine at least needs the time of 6 months, causes vaccine to prepare and is in passive state always.

3. medical treatment

Use the Chinese herbal medicine improving immunity to coordinate responsive antibacterials to be used for the treatment of enteritis and salpingitis, then coordinate doxycycline or tylosin etc., when occurring that laying rate declines, in feedstuff, add vitamin B12, sodium silenite-vitamin E.Although above medical treatment to a certain degree can control mortality rate, improve immunity of fowl, it is not obvious to there is curative effect in current drug main, facts have proved that mortality rate is still very high.

Summary of the invention

The object of the invention is to overcome the above-mentioned deficiency of prior art and provide a kind of medicine preventing and treating bird flu, medicine of the present invention effectively can prevent and treat avian influenza; Use medicine of the present invention to improve immunity of fowl in advance for the fowl (mainly chicken and duck) not infecting avian influenza especially, have good preventive effect to bird flu; Good therapeutical effect is had for the fowl (mainly chicken and duck) suffering from avian influenza symptom.

Another object of the present invention is to provide a kind of preparation method of said medicine, and its technique is simple, and its crude drug is common, cheap.

Technical scheme of the present invention is: a kind of medicine preventing and treating bird flu, and it is made up of the crude drug of following masses part proportioning: the Radix Astragali 71 ~ 87 parts, Herba Taraxaci 71 ~ 87 parts, Herba Scutellariae Barbatae 71 ~ 87 parts, 29 ~ 35 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 87 parts, Radix Ginseng 71 ~ 87 parts, the Folium Ligustri Lucidi 72 ~ 87 parts, Folium Isatidis 72 ~ 87 parts, Herba Equiseti Hiemalis 71 ~ 87 parts, Ramulus Uncariae Cum Uncis 72 ~ 88 parts, Rhizoma Nelumbinis 86 ~ 106 parts, Fructus Rosae Laevigatae 71 ~ 87 parts, Herba Menthae 72 ~ 88 parts.

Its further preferred mass part proportioning is: the Radix Astragali 75 ~ 87 parts, Herba Taraxaci 75 ~ 87 parts, Herba Scutellariae Barbatae 75 ~ 87 parts, 30 ~ 35 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 75 ~ 87 parts, Radix Ginseng 75 ~ 87 parts, the Folium Ligustri Lucidi 75 ~ 87 parts, Folium Isatidis 76 ~ 87 parts, Herba Equiseti Hiemalis 76 ~ 87 parts, Ramulus Uncariae Cum Uncis 76 ~ 88 parts, Rhizoma Nelumbinis 91 ~ 106 parts, Fructus Rosae Laevigatae 75 ~ 87 parts, Herba Menthae 76 ~ 88 parts.

Its further preferred mass part proportioning is: the Radix Astragali 71 ~ 83 parts, Herba Taraxaci 71 ~ 83 parts, Herba Scutellariae Barbatae 71 ~ 83 parts, 29 ~ 34 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 83 parts, Radix Ginseng 71 ~ 83 parts, the Folium Ligustri Lucidi 72 ~ 83 parts, Folium Isatidis 72 ~ 84 parts, Herba Equiseti Hiemalis 71 ~ 83 parts, Ramulus Uncariae Cum Uncis 72 ~ 83 parts, Rhizoma Nelumbinis 86 ~ 101 parts, Fructus Rosae Laevigatae 71 ~ 83 parts, Herba Menthae 72 ~ 84 parts.

Its further preferred mass part proportioning is: the Radix Astragali 75 ~ 83 parts, Herba Taraxaci 75 ~ 83 parts, Herba Scutellariae Barbatae 75 ~ 83 parts, 30 ~ 34 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 75 ~ 83 parts, Radix Ginseng 75 ~ 83 parts, the Folium Ligustri Lucidi 75 ~ 83 parts, Folium Isatidis 76 ~ 84 parts, Herba Equiseti Hiemalis 76 ~ 83 parts, Ramulus Uncariae Cum Uncis 76 ~ 83 parts, Rhizoma Nelumbinis 91 ~ 101 parts, Fructus Rosae Laevigatae 75 ~ 83 parts, Herba Menthae 76 ~ 84 parts.

Its further preferred mass part proportioning is:.

Another technical scheme of the present invention is: a kind of preparation method of preventing and treating the medicine of bird flu, it mainly comprises the steps:

One, raw material is taken

Raw material is taken: the Radix Astragali 71 ~ 87 parts, Herba Taraxaci 71 ~ 87 parts, Herba Scutellariae Barbatae 71 ~ 87 parts, 29 ~ 35 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 87 parts, Radix Ginseng 71 ~ 87 parts, the Folium Ligustri Lucidi 72 ~ 87 parts, Folium Isatidis 72 ~ 87 parts, Herba Equiseti Hiemalis 71 ~ 87 parts, Ramulus Uncariae Cum Uncis 72 ~ 88 parts, Rhizoma Nelumbinis 86 ~ 106 parts, Fructus Rosae Laevigatae 71 ~ 87 parts, Herba Menthae 72 ~ 88 parts by following proportion by weight;

Two, the raw material pulverizing will claimed, mix homogeneously, obtains the medicine preventing and treating bird flu.

The present invention further another technical scheme is: raw material preferred mass part proportioning that step one takes is: the Radix Astragali 71 ~ 83 parts, Herba Taraxaci 71 ~ 83 parts, Herba Scutellariae Barbatae 71 ~ 83 parts, 29 ~ 34 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 83 parts, Radix Ginseng 71 ~ 83 parts, the Folium Ligustri Lucidi 72 ~ 83 parts, Folium Isatidis 72 ~ 84 parts, Herba Equiseti Hiemalis 71 ~ 83 parts, Ramulus Uncariae Cum Uncis 72 ~ 83 parts, Rhizoma Nelumbinis 86 ~ 101 parts, Fructus Rosae Laevigatae 71 ~ 83 parts, Herba Menthae 72 ~ 84 parts.

The present invention further another technical scheme is: raw material preferred mass part proportioning that step one takes is: the Radix Astragali 79 parts, Herba Taraxaci 79 parts, Herba Scutellariae Barbatae 79 parts, 32 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 79 parts, Radix Ginseng 79 parts, the Folium Ligustri Lucidi 79 parts, Folium Isatidis 80 parts, Herba Equiseti Hiemalis 79 parts, Ramulus Uncariae Cum Uncis 80 parts, Rhizoma Nelumbinis 96 parts, Fructus Rosae Laevigatae 79 parts, Herba Menthae 80 parts.

The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 100 ~ 300 mesh sieves.

The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 120 ~ 200 mesh sieves.

The primary symbols that the present invention uses and name resolving as follows:

~: numerical range, such as 1 ~ 5 represents 1 to 5.

The primary raw material medicine that the present invention uses is described as follows:

The Radix Astragali: in Compendium of Material Medica also known as wearing crushed grain, wear mulberry, grass, hundred, Rhizoma Paridis tetraphyllae, (" stilbene " original work are " over sixty years of age "); Abnormal smells from the patient (root) is sweet, tepor, nontoxic; Cure mainly: the yellow disease of urinary obstruction, alcoholic jaundice, nebulousurine, sallow terribly thirsty, old people constipation, stranguria with blood, drench less, spit blood, cough pus hemoptysis, lung abscess, frequent fetal movement, polyhidrosis around the external genitals pruritus due to damp pathogen.There is invigorating the spleen and replenishing QI arresting sweating, control chronic nephritis, the albumen that disappears, removing toxic substances and promoting granulation, the effect such as strengthen the spleen and stomach.The Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting; The Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper; Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.

Herba Taraxaci, the record according to Compendium of Material Medica: Herba Taraxaci, releases name name weeding hoe grass, Herba Taraxaci, Herba crotalariae albidae; Abnormal smells from the patient (Seedling) is sweet, flat, nontoxic." Chinese medicine voluminous dictionary " is recorded: Herba Taraxaci, [different name] wild duck Herba Taraxaci, servant's Herba Taraxaci (" prescriptions worth thousand gold "), Pu Gongcao (" Newly Revised Canon of Materia Medica "), to fall forward public small-mouthed jar (" Bencao Tujing "), Herba Violae (amplification on Canon of Materia Medica), comet comet fourth dish, Hemerocallis citrina Baroni Seedling, Hemerocallis citrina Baroni youth (herbal for Relief of Famines), wood pigeon English (" pungent beautiful volume in heptan "), grandmother's fourth (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), Herba crotalariae albidae, Pu Gongding, Canis familiaris L. silkweed (" detailed outline "), milk grass (" herbal classic is met former "), yellow dog head (" Zhiwu Mingshi Tukao "), foretell DIWUGONG, Herba Clerodendri fortunati (" vegetation is side just "), Herba Malvastri Coromandeliani (" Jiangsu flora "), the herb that [base is former] is Compositae Dandelion plant dandelion, alkali ground Herba Taraxaci, Herba Taraxaci ohwiani, different luxuriant Herba Taraxaci, Taraxacum asiatica Dahlst, Taraxacum erythropodium Kifag etc. belong to various plants together, [function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, cure mainly acute mastitis, lung abscess, acute appendicitis, mumps, scrofula, treat carbuncle toxin, conjunctival congestion and swelling pain, cold, fever, cough, laryngopharynx swelling and pain, gastritis, enteritis, dysentery, hepatitis, cholecystitis, urinary tract infection, snake bite and insect sting, burn and scald.

Herba Scutellariae Barbatae, Pharmacopoeia of the People's Republic of China version in 1985 Herba Portulacae Grandiflorae recorded is this product.Another name: and head is careless, narrow leaf Herba Scutellariae indicae, toothbrush grass, Herba Scutellariae Darbatae, Herba Scutellariae Barbatae, Herba Carpesii Cernui, Aleuritopteris argentea (Gmel.) Fee, purple even grass, little Herba Scutellariae indicae, little Han believes, little scutllaria indica, Herba Carpesii Divaricati grass, box is picked one's ears, scutllaria indica, small stream limit Radix Scutellariae, wild Spica Prunellae, Fang Ercao, half to flower, demifacet flower, inclined head grass, Rabdosia stracheyi(Benth.ex Hook.f.)Hara[Plectranthus stracheyi Benth.ex Hook.f., small size India skullcap, tiger stings red, aftergrass, Herba hyperici attenuati, narrow leaf India skullcap.Prescription name: Herba Portulacae Grandiflorae, Herba Scutellariae Barbatae, fresh Herba Portulacae Grandiflorae.Effect is classified: heat and toxic materials clearing away medicine; Hemorrhage.Section belongs to classification: Labiatae, Scutellaria.Function: heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, inducing diuresis to remove edema, analgesic therapy.Cure mainly: control haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, have sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom.Nature and flavor: acrid in the mouth; Bitter; Cold in nature.Herba Scutellariae Barbatae return through: return lung meridian; Liver Channel; Kidney channel.

Radix Glycyrrhizae: " Chinese medicine voluminous dictionary " is recorded: Radix Glycyrrhizae, [different name] Glycyrrhizae, honey sweet (" herbal classic "), honeywort, black root grass (" not Lu "), state's old (Collective Notes to the Canon of Materia medica), well-informed (" account pearl "), Radix Glycyrrhizae (" florilegium "), Herba Hedyotis cantonensis (" medicinal plants in China will "), sweet root (" Chinese medicinal herbal "), rod grass (" Heilungkiang Chinese medicine "); [base is former] is the root and rhizome of pulse family glycyrrhiza genus Radix Glycyrrhizae, Glycyrrhiza glabra L., Glycyrrhiza inflata Bat.; [function cures mainly] and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Process with controlling weakness of the spleen and stomach, asthenia lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, hysteria, lung productive cough is coughed; Raw with controlling laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, infantile carbuncle, and medicine, alimentary toxicosis.Record according to Compendium of Material Medica: Radix Glycyrrhizae, also sweet, the honeywort of name honey, Glycyrrhizae, grass, well-informed, state is old; Abnormal smells from the patient (root) is sweet, flat, nontoxic.

Rhizoma Acori Graminei: [another name] white flag, prosperous, Rhizoma Acori Graminei, prosperous sun, prosperous grass, Yao time Chinese onion, Yao's fragrant-flowered garlic, haze tallow, spring snow, see disappear, water Rhizoma Acori Graminei, bitter Rhizoma Acori Graminei, powder Chang, Rhizoma Acori Graminei, sword-like leave, Rhizoma Acori Graminei, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek, Herba Kyllingae, Rhizoma et radix valerianae.[source] medical material Ji Yuan: be the rhizome of acorus gramineus araceae plant.Gas fragrance, bitter in the mouth, micro-pungent.So that bar is thick, section color class is white, the dense person of fragrance is good.Meridian distribution of property and flavor: pungent, bitter, temperature.GUIXIN, stomach warp.Function cures mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.

Radix Ginseng: have another name called Sphallerocarpus gracilis, Herba Wedeliae Wallichii, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), SHENCAO, Rhizoma Panacis Japonici, Herba Stellariae Saxatilis, sea is fertile, drawn grain is also red, abnormal smells from the patient (root) is sweet, be slightly cold, nontoxic, cure mainly: the disease of cloudy thanks to YANG exhaustion is (giddy, spontaneous perspiration, rale, large pulse), fullness and hardness of the abdomen in the heart, side of body subinverse gas robs the heart, deficiency of spleen-QI and stomach-QI, anorexia, appetizing is reduced phlegm, cold syndrome of the stomach fullness caused by stagnant QI, feeling of hunger but failing to eat, insufficiency of stomach bad habit, or vomiting has expectorant, regurgitation (drink vomiting while food taken, patient's languishment), pregnant woman suffers from abdominal pain acid regurgitation, can not diet, yang deficiency is panted, spontaneous sweating, to breathe hard dizziness, dyspnea with rapid respiration wild, puerperal breathing heavily, puerperal all void, heating, spontaneous perspiration, puerperal, stool can not be much hemorrhage, to grow wild footling presentation, palpitation with a distress feeling spontaneous perspiration, deficiency of heart-QI, chronic cough of deficiency lung, breathe heavily hemoptysis of coughing, weak pulse is unable, cough is spitted blood, haematemesis hematochezia, Blood gushed forth in fountains, nose bleeding is more than, deficiency of YIN hematuria, water is thirsty, dysentery is fainted for a long time, six kinds of pulses Lignum Aquilariae Resinatum, prohibit mouth dysentery, old man's dysentery of deficiency type is more than, can not diet, typhoid fever bad disease (typhoid fever or other epidemic diseases, disease is weak for a long time, deep-hidden pulse, syncope), typhoid fever faints inverse (slight fever, agitation, six deep-thready pulses), muscles and bones wind pain, little eclampsia knots, after children's is frightened, eye is oblique, Scolopendra, honeybee a kind of scorpion sting.There are the effects such as QI invigorating heart tonifying, detumescence, beneficial brain refreshment.

The Folium Ligustri Lucidi: [another name] Folium Ilicis Purpureae (" sea side "), native Buddha's warrior attendant leaf, firecracker leaf (" Guizhou side's medicine among the people collection ").The blade of [source] Oleaceae plants Fructus Ligustri Lucidi, the whole year can adopt.[nature and flavor] " detailed outline ": micro-hardship is flat, nontoxic.[function cures mainly] dispels the wind, improving eyesight, detumescence, pain relieving.Control head's dusk pain, wind heat is red follows, skin ulcer turgescence canker, scalds, stomatitis.1. " detailed outline ": except wind falls apart blood, subduing swelling and relieving pain.Control head's dusk pain, all malignant boil swell, and top gem of a girdle-pendant skin ulcer is festered, person of a specified duration with decocting in water, take advantage of heat posted it, again and again change easily, rice vinegar boils also can.Aphtha of the mouth and tongue, glossoncus expansion, smashes juice impregnation salivation.2. " Guizhou side among the people medicine collection ": external application is only hemorrhage due to wound, and anti-inflammation detumescence, controls burn.Take orally and can cough-relieving cough, emesis blood.

Folium Isatidis: [another name] Folium Isatidis (" book on Chinese herbal medicine is through Ji Zhuan "), LANYE, blue dish, blue buttocks leaf.The leaf of [source] cruciferae isatis or branch and leaf.Medical material nature and flavor: bitter, cold.1. " not Lu ": " bitter in the mouth is Great Cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth." 3. " detailed outline ": " gas is trembled with fear, and mildly bitter flavor is salty." [return through] enters liver, the heart, stomach warp.1. " book on Chinese herbal medicine must be joined ": " enter foot sun bright, meridian of Hand-SHAO YIN." 2. " book on Chinese herbal medicine is new again ": " enter liver, spleen two warp." 3. " book on Chinese herbal medicine brief points ": " enter sufficient fall the moon, shaoyin channel."。Function cures mainly: heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.

Herba Equiseti Hiemalis: another name: file grass, nib grass, Herba equiseti ramosissimi, Herba Equiseti Hiemalis etc. are the herb of Equisetaceae plant Herba Equiseti Hiemalis.[nature and flavor] are sweet, bitter, flat.[return through] returns lung, Liver Channel.[function cures mainly] wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.Control the raw nebula of order, epiphora induced by wind, discharging fresh blood stool, dysentery, de-liver, malaria, laryngalgia, carbuncle.1. " good blessing book on Chinese herbal medicine ": " argument disease, nebula removing film.Removing food stagnancy block again, the liver benefiting gallbladder, improving eyesight, treats hemorrhoidal hamorrhage, dysentery relieving and married woman's metrorrhagia."; 2. " detailed outline ": " expelling pathogenic factors from muscles, arresting lacrimation, hemostasis, curing rheumatism, colic, large intestine proctoptosis."; 3. " book on Chinese herbal medicine just ": " diaphoresis, expelling pathogenic factors from muscles.Cure the wound cold, malaria.Curing rheumatism, loose pathogenic fire."

Ramulus Uncariae Cum Uncis, calls large Ramulus Uncariae Cum Uncis, Ramulus Uncariae macrophyllae, is a kind of evergreen liana.Ramulus Uncariae Cum Uncis begins to be loaded in " Mingyi Bielu ", original name Ramulus Uncariae cum Uncis.[section belongs to classification]: Rubiaceae.[effect classification]: liver wind calming drug.[another name]: hang rattan, Ramulus Uncariae Cum Uncis hook, fishhook rattan, Oriolus chinensis diffusus pawl wind, tender hook hook, golden Ramulus Uncariae Cum Uncis, hook rattan, Ramulus Uncariae Cum Uncis, Ramulus Uncariae Cum Uncis, lifting lug, Ramulus Uncariae macrophyllae, Wang Gambirplant Branchlet, reversal of the natural order of things are perverse.[nature and flavor]: sweetness and bitterness; Be slightly cold.[return through]: < Liver Channel < heart channel.[function]: heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.[curing mainly]: infantile convulsion; Night cry; Intenseness of heat wind symptom; Eclamposia; Dizziness due to hyperactivity of liver-YANG; Liver-fire distending pain in the head.

Rhizoma Nelumbinis: also known as Rhizoma Nelumbinis, belong to nymphaeaceae plant, Rhizoma Nelumbinis is micro-sweet and crisp, can eat raw and also can cook, and medical value is quite high, its Gen Genyeye, stamen or pistil fruit, and fixed-point-free power automorphism is precious, all can nourish and be used as medicine.Nature and flavor: sweet in the mouth, cool in nature, main invigorating middle warmer is burnt, reposes, physical strength profiting.Energy clearing away heat and promoting production of body fluid, cooling blood for hemostasis, dissipating blood stasis blood.Ripe tepor, can strengthen the spleen and stomach, antidiarrheal, beneficial blood, granulation promoting.Cure mainly: invigorating middle warmer is reposed, except all kinds of diseases and ailments.Informal dress, makes light of one's life by commiting suicide always resistance to, life lengthening.Tonification twelve regular channels vim and vigour, flat body Nei Yangre crosses Sheng, hyperactivity of fire.To lay one's heart bear kidney, thick the intestines and stomach, controlling nocturnal emission with astringent drugs gas, bone and muscle strengthening, tonifying deficiency, sharp knowledge, and eliminating cold-damp, only the splenic diarrhea chronic dysentery, the diseases such as woman's Massive Bleeding in non-menstrual period.Eat raw too much, fine motion gas.Smash food of cooking congee with rice to pieces, make people strong, steamed wheaten foods might as well.The dry puckery people that defecates can not eat it.Lotus is strengthening the spleen fruit.

Fructus Rosae Laevigatae: Fructus Rosae Laevigatae is called: Cortex Hemipteleae Davidii, sub, golden small-mouthed jar of Fructus Rosae Normalis, Catunaregam spinosa (Thunb.) Tirveng., Gallus jabouillei chieftain, sugared Oriolus chinensis diffusus, sugar bowl, confection, Mel tank, Semen Arecae, golden tall bottle with spout, sugared Fructus Citri tangerinae, yellow tea bottle, rattan hook, Mantidis fruit, sugared bur, Radix Ribis manschurici, thorn Fructus Canarii albi, Radix Ribis manschurici, the blue stalk of thorn are rosaceous plant.Source: this product is the dry mature fruit of rosaceous plant Fructus Rosae Laevigatae.[performance] sweet in the mouth, micro-acid, puckery, property is put down.Energy controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.Function cures mainly: 1, controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.2, reducing urination for preventing enuresis.3, relieving cough and asthma, spasmolytic.4, blood fat reducing.5, anti-inflammation.[nature and flavor]: really: sour, sweet, flat, nontoxic.[function]: astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, stopping leak dysentery, urine reducing.[effect]: astringent therapy, controlling nocturnal emission with astringent drugs, antidiarrheal.Be applicable to the diseases such as spermatorrhea, seminal emission, the enuresis, frequent micturition, insufficiency of the spleen chronic diarrhea and women's leukorrhagia, uterine prolapse.During catching a cold or heating patient's inedibility.

Herba Menthae: another name wild mint.Function cures mainly: 1. for anemopyretic cold, epidemic febrile disease from the beginning of.These product are pungent to disperse, cool to heat clearing away, clear light cool loose, are the product that dispelling wind and heat pathogens is conventional, thus available control anemopyretic cold or epidemic febrile disease from the beginning of, evilly to defend point, headache, generate heat, the micro evil wind person of trembling with fear, often join Flos Lonicerae, stick up, Fructus Arctii, Herba Schizonepetae be equal to use, as Lonicerae and Forsythiae Powder.2. for conjunctival congestion of having a headache, laryngopharynx swelling and pain.These product lightly float and rise floating, awakening consciousness, and merit is kind evacuates part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, throat.Attack with controlling in wind heat, headache conjunctival congestion, polygamy closes Folium Mori, Flos Chrysanthemi, Fructus Viticis is equivalent uses; Stopping up Sheng, laryngopharynx swelling and pain with controlling wind heat, often joining Radix Platycodonis, Radix Glycyrrhizae, Bombyx Batryticatus, Herba Schizonepetae, the equivalent use of Radix Saposhnikoviae.3. for measles without adequate eruption, rubella pruritus.This product light weight a surname is loose, having dispelling wind and heat pathogens, declares the merit of malicious rash, with controlling wind heat bundle table, measles without adequate eruption, often joining Periostracum Cicadae, Herba Schizonepetae, Fructus Arctii, Radix Arnebiae (Radix Lithospermi) etc., as rash soup; Treatment rubella pruritus, can be equal to use with Radix Sophorae Flavescentis, Cortex Dictamni, Radix Saposhnikoviae, get the effect that its rash of dispeling the wind is antipruritic.4. for stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.These product double enter Liver Channel, can dispersing the stagnated live-QI to relieve the stagnation of QI, often coordinate the product of the depressed liver-energy dispersing and QI regulating regulating menstruations such as Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, treatment stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, menoxenia, as XIAOYAO POWDER.Meridian distribution of property and flavor: pungent is cool.Enter lung meridian, Liver Channel.

" Chinese medicine voluminous dictionary ": the second edition that Nanjing University of Traditional Chinese Medicine writes " Chinese medicine voluminous dictionary ", Shanghai Century publishes limited company and Shanghai science tech publishing house publishes and distributes.

Efficacy of drugs of the present invention with cure mainly:

1. medicine of the present invention has effect of heat-clearing and toxic substances removing, cooling blood, expelling wind, enhancing immunity;

2. the following symptom of pair fowl has obvious preventive and therapeutic effect: body temperature is elevated to 38.0 DEG C ~ 40.0 DEG C, and spirit is depressed, fb dur loss of appetite or do not eat, and feather pine disorderly, furiously to shed tears, conjunctiva inflammation, secretions increase, respiratory disorder, coughs, gets rid of head, sneeze;

3. the present inventor is by a large amount of contrast controlling experiment, and the medicine of sufficient proof control of the present invention bird flu has obvious preventive and therapeutic action to avian influenza, can control the mortality rate of fowl well.

4. pure Chinese medicine is made, few side effects.

In order to be illustrated more clearly in the present invention, enumerate following examples, but it is without any restrictions to scope of invention.

Detailed description of the invention

embodiment 1

Take the Radix Astragali 790 grams, Herba Taraxaci 790 grams, Herba Scutellariae Barbatae 790 grams, 320 grams, Radix Glycyrrhizae, Rhizoma Acori Graminei 790 grams, Radix Ginseng grams 790 grams, the Folium Ligustri Lucidi 790 grams, Folium Isatidis 800 grams, Herba Equiseti Hiemalis 790 grams, Ramulus Uncariae Cum Uncis 800 grams, Rhizoma Nelumbinis 960 grams, Fructus Rosae Laevigatae 790 grams, Herba Menthae 800 grams, these material compositions are the quality after drying, 100 ~ 300 orders (being generally 120 ~ 200 orders) are ground into super micron mill, mix homogeneously, then pack with plastic bag sealing, the medicine of obtained control bird flu.

using method:during each nursing, according to forage volume, the medicine (medicine of the control bird flu that the present embodiment that namely each hundred kg diet takes 1.5 to 2.0 kilograms obtains) of the control bird flu that the present embodiment taking 1.5 ~ 2.0% feeding qualities obtains, again by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day is sooner or later each feeds once, within 4 ~ 7 days, is a course for the treatment of, feeds a course for the treatment of of this medicine every 30 days.

contrast control test:

1. the symptom standard (for judging the state of an illness) for observing:

Symptom 1: non-evident sympton, avian flu virus detection is negative, namely healthy;

Symptom 2: body temperature is elevated to 38.0 DEG C ~ 40.0 DEG C, sick chicken spirit is depressed, fb dur loss of appetite or do not eat, feather pine disorderly, is envious and sheds tears, conjunctiva inflammation, secretions increase, respiratory disorder, cough, get rid of head, sneeze, sample (being generally propose serum) detects bird flu virus and is positive, and namely infects;

Symptom 3: body temperature is elevated to 40.5 DEG C ~ 41 DEG C, and breathing is the devil, serious dysentery, row's yellow green feces, skin is dark violet without hair place color, has nervous symptoms, and performance head and neck, to layback, is twitched, movement disorder, paralysis etc., sample (being generally propose serum) detects bird flu virus and is positive; Namely serious;

Symptom 4: body temperature about 41 DEG C, in septicemia phenomenon, extensive bleeding; Peritoneum, serous coat, intestinal are hemorrhage to some extent, skin, cockscomb, wattle often have hyperemia, hemorrhage and gangrenosum acne symptom, cloaca hemorrhagic necrosis; Can see stomach fat, lower limb flesh, chest muscle are hemorrhage, sample (being generally propose serum) detects bird flu virus and is positive; Namely be critically ill;

Symptom 5: dead.

2. prevent and treat and be divided into four-stage (natural law in each stage all goes out the birthday from chicken and starts at) course for the treatment of:

First stage: the 1st day ~ the 30th day;

Second stage: the 31st day ~ the 60th day;

Phase III: the 61st day ~ the 120th day;

Fourth stage: the 121st day ~ the 180th day.

3. group experiment.

When having bird flu in Hunan in 2011, the present inventor have purchased chicken 100 (birth 5-10 days), be divided into two groups, often organize 50, Hengyang one Yang Zhi ?raise, farming site wire gauze between two groups of chickens is separated, first group of 50 chicken are that the medicine of the control bird flu obtained by the present embodiment carries out controlling experiment group (i.e. embodiment controlling experiment group), and second group of 50 chicken is for carrying out contrast controlling experiment group (i.e. contrast controlling experiment group) by currently available vaccines, existing vaccines and antibiotic.

4. embodiment controlling experiment group: the medicine of the control bird flu that the present embodiment adding 1.5 ~ 2.0% respectively in feedstuff during first group of 50 chickens morning and evening feeding obtains, continuous use 7 days, during by the 10th day, be first course for the treatment of (i.e. first stage), 3 chickens are had to occur that namely avian influenza symptom 2(infects), carry out avian flu virus detection to all 50 chickens, result detects that the bird flu virus of 5 chickens is for positive, and it is namely healthy that all the other are symptom 1(); After 30 day, feed the feedstuff 7 days of the medicine adding the present embodiment again, be second course for the treatment of (i.e. second stage), have 4 chickens to occur that namely avian influenza symptom 2(infects), all the other are symptom 1; The feedstuff 4 days of the medicine adding the present embodiment is fed again again through 30 days, not only fed the feedstuff 4 days of the medicine adding the present embodiment through 30 days, be the 3rd course for the treatment of (i.e. phase III), have 2 chickens to occur that namely avian influenza symptom 2(infects), all the other are symptom 1; The feedstuff 4 days of the medicine adding the present embodiment is fed again again through 30 days, not only fed the feedstuff 4 days of the medicine adding the present embodiment through 30 days, when delivering for sale to 6 months (fourth stage), be all symptom 1(be namely all healthy chicken), the average weight of 50 chickens increases by 1.3 kilograms, does not occur death.

5. contrast controlling experiment group:

The inoculation of injection avian influenza virus vaccine, then coordinate doxycycline or tylosin etc., the medicine such as vitamin B12, sodium silenite-vitamin E.

Second group of 150 chicken all injects avian influenza virus vaccine inoculation control, through 10 days, i.e. and the first stage, 5 chickens are had to occur symptom 2, have 2 chickens to occur symptom 3, all the other are symptom 1, then to occurring that the chicken of symptom 2,3 feeds doxycycline, tylosin is treated; During second stage (during by the 60th day), there are 10 chickens to occur symptom 2, have 8 chickens to occur symptom 3, have 2 chickens to occur symptom 4, all the other are symptom 1, then to occurring that the chicken of symptom 2, symptom 3, symptom 4 feeds doxycycline, tylosin, once control is fed, one time 4 days every 30 days; During the phase III (during by the 120th day), 15 chickens are had to occur symptom 2,10 chickens are had to occur symptom 3,8 chickens are had to occur symptom 4, have 8 chickens to occur symptom 5 (namely dead), all the other are symptom 1, then to occurring that the chicken of symptom 2, symptom 3, symptom 4 feeds doxycycline, tylosin, once control is fed, one time 4 days every 30 days; During fourth stage (during by the 180th day), have 10 chickens to occur symptom 2, have 11 chickens to occur symptom 3, have 8 chickens to occur symptom 4, have again 10 chickens to occur symptom 5 (namely dead), all the other are symptom 1, remaining chicken average weight gain 0.7 kilogram; Mortality rate is 36%.

embodiment 2-14

Embodiment 2-14 is except raw material mass mixture ratio is different from embodiment 1, its raw material type is identical with embodiment 1 with step of preparation process, the raw material that embodiment 2-14 uses and quality as shown in Table 1 below, table 1 below illustrates raw material and quality that embodiment 1-14 uses.

Table 1

The present inventor also done Contrast control test substantially the same manner as Example 1 at the different local medicine of embodiment 2-14 that adopts respectively during 2011 to 2013 years occur bird flu, and embodiment 1-14 is contrast test 1400 chickens altogether.When feeding by medicine of the present invention 700 chickens to 6 month carrying out avian influenza prevention, only have 10 death, mortality rate is 1.4%, is weak and sickly chicken itself mostly, the chicken average weight gain 1.2 kilograms of living; And when adopting prior art to prevent and treat 700 chickens to 6 month of comparative example, 220 death, mortality rate 31%, the chicken average weight gain 0.8 kilogram of living.Show that medicine of the present invention has good prevention effect to avian influenza by contrast culture experiment.

The present inventor also adopts the present invention respectively to implement, during 2011 to 2013 years, contrast culture experiment is done to 1000 ducks, by the time substantially identical with chicken culture experiment result, the duck adopting this medicine to feed 500, duck mortality rate is 1.1%, weak and sickly duck itself mostly, the duck average weight gain 1.5 kilograms of living; And duck 500 the duck mortality rates adopting prior art to prevent and treat are 29%, the duck average weight gain 0.9 kilogram of living.

As can be seen from above contrast controlling experiment data, the medicine of bird flu of the present invention has obvious preventive and therapeutic action to avian influenza.

So the present invention is not limited to the protective agents as bird flu, as long as the composition of raw materials medicine identical or equivalent with the present invention just drops within protection scope of the present invention.The raw material of the protective agents same recipe with control bird flu of the present invention is made any one Chinese medicine preparation also drop within protection scope of the present invention, as long as the medicine that namely composition of raw materials is identical with the present invention just drops within protection scope of the present invention.

Claims (10)

1. prevent and treat a medicine for bird flu, it is characterized in that: it is made up of the crude drug of following masses part proportioning: the Radix Astragali 71 ~ 87 parts, Herba Taraxaci 71 ~ 87 parts, Herba Scutellariae Barbatae 71 ~ 87 parts, 29 ~ 35 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 87 parts, Radix Ginseng 71 ~ 87 parts, the Folium Ligustri Lucidi 72 ~ 87 parts, Folium Isatidis 72 ~ 87 parts, Herba Equiseti Hiemalis 71 ~ 87 parts, Ramulus Uncariae Cum Uncis 72 ~ 88 parts, Rhizoma Nelumbinis 86 ~ 106 parts, Fructus Rosae Laevigatae 71 ~ 87 parts, Herba Menthae 72 ~ 88 parts.

2. the medicine of control bird flu according to claim 1, is characterized in that: the Radix Astragali 75 ~ 87 parts, Herba Taraxaci 75 ~ 87 parts, Herba Scutellariae Barbatae 75 ~ 87 parts, 30 ~ 35 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 75 ~ 87 parts, Radix Ginseng 75 ~ 87 parts, the Folium Ligustri Lucidi 75 ~ 87 parts, Folium Isatidis 76 ~ 87 parts, Herba Equiseti Hiemalis 76 ~ 87 parts, Ramulus Uncariae Cum Uncis 76 ~ 88 parts, Rhizoma Nelumbinis 91 ~ 106 parts, Fructus Rosae Laevigatae 75 ~ 87 parts, Herba Menthae 76 ~ 88 parts.

3. the medicine of control bird flu according to claim 1, is characterized in that: the Radix Astragali 71 ~ 83 parts, Herba Taraxaci 71 ~ 83 parts, Herba Scutellariae Barbatae 71 ~ 83 parts, 29 ~ 34 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 83 parts, Radix Ginseng 71 ~ 83 parts, the Folium Ligustri Lucidi 72 ~ 83 parts, Folium Isatidis 72 ~ 84 parts, Herba Equiseti Hiemalis 71 ~ 83 parts, Ramulus Uncariae Cum Uncis 72 ~ 83 parts, Rhizoma Nelumbinis 86 ~ 101 parts, Fructus Rosae Laevigatae 71 ~ 83 parts, Herba Menthae 72 ~ 84 parts.

4. the medicine of control bird flu according to claim 1, is characterized in that: the Radix Astragali 75 ~ 83 parts, Herba Taraxaci 75 ~ 83 parts, Herba Scutellariae Barbatae 75 ~ 83 parts, 30 ~ 34 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 75 ~ 83 parts, Radix Ginseng 75 ~ 83 parts, the Folium Ligustri Lucidi 75 ~ 83 parts, Folium Isatidis 76 ~ 84 parts, Herba Equiseti Hiemalis 76 ~ 83 parts, Ramulus Uncariae Cum Uncis 76 ~ 83 parts, Rhizoma Nelumbinis 91 ~ 101 parts, Fructus Rosae Laevigatae 75 ~ 83 parts, Herba Menthae 76 ~ 84 parts.

5. the medicine of the control bird flu according to claim 1 or 2 or 3 or 4, is characterized in that: the Radix Astragali 79 parts, Herba Taraxaci 79 parts, Herba Scutellariae Barbatae 79 parts, 32 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 79 parts, Radix Ginseng 79 parts, the Folium Ligustri Lucidi 79 parts, Folium Isatidis 80 parts, Herba Equiseti Hiemalis 79 parts, Ramulus Uncariae Cum Uncis 80 parts, Rhizoma Nelumbinis 96 parts, Fructus Rosae Laevigatae 79 parts, Herba Menthae 80 parts.

6. prevent and treat a preparation method for the medicine of bird flu, it is characterized in that: it mainly comprises the steps:

One, raw material is taken

Raw material is taken: the Radix Astragali 71 ~ 87 parts, Herba Taraxaci 71 ~ 87 parts, Herba Scutellariae Barbatae 71 ~ 87 parts, 29 ~ 35 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 71 ~ 87 parts, Radix Ginseng 71 ~ 87 parts, the Folium Ligustri Lucidi 72 ~ 87 parts, Folium Isatidis 72 ~ 87 parts, Herba Equiseti Hiemalis 71 ~ 87 parts, Ramulus Uncariae Cum Uncis 72 ~ 88 parts, Rhizoma Nelumbinis 86 ~ 106 parts, Fructus Rosae Laevigatae 71 ~ 87 parts, Herba Menthae 72 ~ 88 parts by following proportion by weight;

Two, the raw material pulverizing will claimed, mix homogeneously, obtains the medicine preventing and treating bird flu.

7. the preparation method of the medicine of control bird flu according to claim 6, is characterized in that: raw materials quality part proportioning that step one takes is: the Radix Astragali 75 ~ 83 parts, Herba Taraxaci 75 ~ 83 parts, Herba Scutellariae Barbatae 75 ~ 83 parts, 30 ~ 34 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 75 ~ 83 parts, Radix Ginseng 75 ~ 83 parts, the Folium Ligustri Lucidi 75 ~ 83 parts, Folium Isatidis 76 ~ 84 parts, Herba Equiseti Hiemalis 76 ~ 83 parts, Ramulus Uncariae Cum Uncis 76 ~ 83 parts, Rhizoma Nelumbinis 91 ~ 101 parts, Fructus Rosae Laevigatae 75 ~ 83 parts, Herba Menthae 76 ~ 84 parts.

8. the preparation method of the medicine of control bird flu according to claim 6, is characterized in that: raw materials quality part proportioning that step one takes is: the Radix Astragali 79 parts, Herba Taraxaci 79 parts, Herba Scutellariae Barbatae 79 parts, 32 parts, Radix Glycyrrhizae, Rhizoma Acori Graminei 79 parts, Radix Ginseng 79 parts, the Folium Ligustri Lucidi 79 parts, Folium Isatidis 80 parts, Herba Equiseti Hiemalis 79 parts, Ramulus Uncariae Cum Uncis 80 parts, Rhizoma Nelumbinis 96 parts, Fructus Rosae Laevigatae 79 parts, Herba Menthae 80 parts.

9. the preparation method of the medicine of the control bird flu according to claim 6 or 7 or 8, is characterized in that: after step 2 raw material pulverizing, crosses 100 ~ 300 mesh sieves.

10. the preparation method of the medicine of control bird flu according to claim 9, is characterized in that: after step 2 raw material pulverizing, crosses 120 ~ 200 mesh sieves.