CN102078419B - Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof - Google Patents
Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof Download PDFInfo
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- CN102078419B CN102078419B CN201010603652A CN201010603652A CN102078419B CN 102078419 B CN102078419 B CN 102078419B CN 201010603652 A CN201010603652 A CN 201010603652A CN 201010603652 A CN201010603652 A CN 201010603652A CN 102078419 B CN102078419 B CN 102078419B
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Abstract
The invention discloses a medicine for preventing and treating porcine reproductive and respiratory syndrome (PRRS). The medicament is prepared by smashing and uniformly mixing the following main crude drugs in parts by weight: 9-11 parts of pine needles, 1.5-2.5 parts of dried tangerine or orange peel, 0.8-1.2 parts of white ginseng, 0.8-1.2 parts of scutellaria baicalensis, 0.8-1.2 parts of golden cypress, 1.5-2.5 parts of gardenia jasminoides ellis, 1.5-2.5 parts of isatis root, 0.2-0.4 part of liquorice, 1.5-2.5 parts of honeysuckle flower, 1.5-2.5 parts of oriental wormwood, 3.5-4.5 parts of milkvetch root, 1.5-2.5 parts of cyrtomium rhizome, 0.8-1.2 parts of fructus forsythiae, 1.5-2.5 parts of platycodon grandiflorum, 0.8-1.2 parts of giant knotweed rhizome and 0.3-0.5 part of milkvetch root polysaccharide. The medicament has a better preventing function on pigs which are not infected by the PRRS, has a good therapeutical effect on pigs which suffer from moderate PRRS and also has an obvious control effect on swine influenza, swine streptococcosis and swine erysipelas.
Description
Technical field
The present invention relates to medicine of boar epidemic diseases control and preparation method thereof, particularly a kind of medicine that pig blue-ear disease, swine influenza, pig streptococcicosis and pig erysipelas is had obvious prevention and therapeutical effect and preparation method thereof.
Background technology
In recent years, pig blue-ear disease (full name Porcine reproductive and respiratory syndrome (Porcine reproductive and respiratory syndrome is widely current, PRRS)), it is to play reproductive and respiratory syndrome poison vaccine to pig that present people prevent and treat the common way of pig blue-ear disease, and treat with some antibiotic, but effect is unsatisfactory, in popular season of pig blue-ear disease and place, extremely forgetting of a large amount of pigs appears in the raiser of most of pig, serious pig extremely forget rate more than 50%, caused very big loss for the family of raising pigs.
Summary of the invention
The objective of the invention is to overcome the above-mentioned deficiency of prior art and a kind of medicine of preventing and treating pig blue-ear disease is provided, medicine of the present invention can effectively be prevented and treated pig blue-ear disease, use medicine of the present invention that better preventive effect is arranged in advance for the pig that does not have infected pigs's reproductive and respiratory syndrome especially, for the pig that suffers from moderate pig blue-ear disease symptom good therapeutical effect is arranged, it still has tangible preventive and therapeutic effect to swine influenza, pig streptococcicosis, pig erysipelas.
Another object of the present invention provides manufacturing method for above mentioned medicine, and its technology is simple, and its crude drug is common, cheap.
Technical scheme of the present invention is: a kind of medicine of preventing and treating pig blue-ear disease, it mainly is to be made by following bulk drugs: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of YINZHEN, 3.5～4.5 parts of the Radixs Astragali, 0.3～0.5 part of astragalus polysaccharides.
Further optimal technical scheme of the present invention is: 10 parts of Folium Pinis, 2 parts of Pericarpium Citri Reticulataes, 1 part of Radix Ginseng, 1 part of Radix Scutellariae, 1 part of Cortex Phellodendri, 2 parts of Yellow Fructus Gardeniaes, 2 parts of Radix Isatidis, 0.3 part in Radix Glycyrrhizae, 2 parts of Flos Loniceraes, 2 parts of YINZHEN, 4 parts of the Radixs Astragali, 0.4 part of astragalus polysaccharides.
Further optimal technical scheme of the present invention is: 9 parts of Folium Pinis, 1.5 parts of Pericarpium Citri Reticulataes, 0.8 part of Radix Ginseng, 0.8 part of Radix Scutellariae, 0.8 part of Cortex Phellodendri, 1.5 parts of Yellow Fructus Gardeniaes, 1.5 parts of Radix Isatidis, 0.2 part in Radix Glycyrrhizae, 1.5 parts of Flos Loniceraes, 1.5 parts of YINZHEN, 3.5 parts of the Radixs Astragali, 0.3 part of astragalus polysaccharides.
Further optimal technical scheme of the present invention is: 11 parts of Folium Pinis, 2.5 parts of Pericarpium Citri Reticulataes, 1.2 parts of Radix Ginseng, 1.2 parts of Radix Scutellariaes, 1.2 parts of Cortex Phellodendris, 2.5 parts of Yellow Fructus Gardeniaes, 2.5 parts of Radix Isatidis, 0.4 part in Radix Glycyrrhizae, 2.5 parts of Flos Loniceraes, 2.5 parts of YINZHEN, 4.5 parts of the Radixs Astragali, 0.5 part of astragalus polysaccharides.
Further again technical scheme of the present invention is: it also comprises following bulk drugs: 1.5～2.5 parts of Rhizoma Osmundae, 0.8～1.2 part of Fructus Forsythiae, 1.5～2.5 parts of Radix Platycodoniss, 0.8～1.2 part of Rhizoma Polygoni Cuspidati.
Further optimal technical scheme of the present invention is: a kind of medicine of preventing and treating pig blue-ear disease, it mainly is to be made by following bulk drugs: 10 parts of Folium Pinis, 2 parts of Pericarpium Citri Reticulataes, 1 part of Radix Ginseng, 1 part of Radix Scutellariae, 1 part of Cortex Phellodendri, 2 parts of Yellow Fructus Gardeniaes, 2 parts of Radix Isatidis, 0.3 part in Radix Glycyrrhizae, 2 parts of Flos Loniceraes, 2 parts of YINZHEN, 4 parts of the Radixs Astragali, 0.4 part of astragalus polysaccharides, 2 parts of Rhizoma Osmundae, 1 part of Fructus Forsythiae, 2 parts of Radix Platycodoniss, 1 part of Rhizoma Polygoni Cuspidati.
Further optimal technical scheme of the present invention is: a kind of medicine of preventing and treating pig blue-ear disease, it mainly is to be made by following bulk drugs: 9 parts of Folium Pinis, 1.5 parts of Pericarpium Citri Reticulataes, 0.8 part of Radix Ginseng, 0.8 part of Radix Scutellariae, 0.8 part of Cortex Phellodendri, 1.5 parts of Yellow Fructus Gardeniaes, 1.5 parts of Radix Isatidis, 0.2 part in Radix Glycyrrhizae, 1.5 parts of Flos Loniceraes, 1.5 parts of YINZHEN, 3.5 parts of the Radixs Astragali, 0.3 part of astragalus polysaccharides, 1.5 parts of Rhizoma Osmundae, 0.8 part of Fructus Forsythiae, 1.5 parts of Radix Platycodoniss, 0.8 part of Rhizoma Polygoni Cuspidati.
Further optimal technical scheme of the present invention is: a kind of medicine of preventing and treating pig blue-ear disease, it mainly is to be made by following bulk drugs: 11 parts of Folium Pinis, 2.5 parts of Pericarpium Citri Reticulataes, 1.2 parts of Radix Ginseng, 1.2 parts of Radix Scutellariaes, 1.2 parts of Cortex Phellodendris, 2.5 parts of Yellow Fructus Gardeniaes, 2.5 parts of Radix Isatidis, 0.4 part in Radix Glycyrrhizae, 2.5 parts of Flos Loniceraes, 2.5 parts of YINZHEN, 4.5 parts of the Radixs Astragali, 0.5 part of astragalus polysaccharides, 2.5 parts of Rhizoma Osmundae, 1.2 parts of Fructus Forsythiaes, 2.5 parts of Radix Platycodoniss, 1.2 parts of Rhizoma Polygoni Cuspidati.
Another technical scheme of the present invention is: a kind of preparation method of preventing and treating the medicine of pig blue-ear disease, it comprises the steps:
One, takes by weighing raw material: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of YINZHEN, 3.5～4.5 parts of the Radixs Astragali, 0.3～0.5 part of astragalus polysaccharides;
Two, will claim raw material pulverizing, mix homogeneously obtains preventing and treating the medicine of pig blue-ear disease.
The present invention further another technical scheme is: the raw material that the first step takes by weighing also comprises: 1.5～2.5 parts of Rhizoma Osmundae, 0.8～1.2 part of Fructus Forsythiae, 1.5～2.5 parts of Radix Platycodoniss, 0.8～1.2 part of Rhizoma Polygoni Cuspidati.
The explanation of the primary raw material medicine that the present invention uses:
Folium Pini comes from Collective Notes to the Canon of Materia medica; Another name: bristles Folium Pini, Folium Pini, illawarra mountain pine palpus, Folium Pini; Medical material Ji Yuan: be the needle of pinaceae plant Pinus armandi Franch-P. Komavovii Lavl., Pinus taiwanesis, Pinus massoniana Lamb, Pollen pini thunbergii, Pinus tabuliformis, pinus yunnanensis faranch, Pinus koraiensis etc.; Pharmacological action: the central nervous system is had sedation; Antiinflammatory action; Effect for reducing blood fat; Delaying senility function; The effect of anti-hepatitis B virus surface antigen.
Pericarpium Citri Reticulatae, another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.Mature peel for rutaceae orange and variety thereof.Compendium of Material Medica: it is to hundred and always get the regulate the flow of vital energy merit of dampness of chess, then mends with tonic, then rushes down with cathartic, then rises with Hydrargyri Oxydum Rubrum, then falls with falling medicine.Which vigour Rhizoma Anemarrhenae of spleen, lung are to take the photograph wanting of gas, thus Pericarpium Citri tangerinae be two through edema caused by disorder of QI will, but with join and the reinforcing and reducing lifting also.
Radix Ginseng, mushroom, the another name: Schizophyllum commune Franch, spend in vain, Radix Ginseng; Chinese name: schizophyllum commune; A kind of rare mushroom bacterium that eats the medicine dual-purpose, mushroom body constitution is tough, taste delicate fragrance, delicious tasty and refreshing, nutritious; Radix Ginseng is often referred to sun-dried Radix Ginseng; Be the Araliaceae root of draft plant man ginseng for many years; Section belongs to: a kind of rare mushroom bacterium that eats the medicine dual-purpose of Mycophyta door fungus Schizophyllum commune Franch (schizophyllqaeae); According to nationalitys such as " medicinal fungis " record, and this bacterium " property is flat, sweet in the mouth, and abnormal smells from the patient (root) is bitter, be slightly cold, nontoxic; The effect that liver heat removing and eyesight improving, nourishing and fit keeping function are arranged is obvious to disease curative effects such as infantile night sweat, gynaecopathia, neurasthenia, dizzy tinnitus especially." polysaccharide (SPG) that from schizophyllum commune, extracts, can stimulate the mononuclear phagocyte system activity, chronic bacterial infection there is significant defence usefulness, tumor there is inhibitory action; The organic acid of its mycelia submerged fermentation output is widely used in aspects such as food, medical industry and biochemistry.
Rhizoma Osmundae: medicine name: Dryopteris bissetiaha (Bak) C. Chr-Nephrodium bisseianum Bak; Classification: Dryopteridaceae (Dryopteridaceae), Dryopteris (Dryopteris); Domestic distribution: Shanxi, Shaanxi, Henan, Shandong, Jiangsu, Anhui, Zhejiang, Jiangxi, Fujian, Hunan, Hubei, Sichuan, Guizhou, Yunnan; The external distribution: Korea, Japan; Popular name: Rhizoma Osmundae; Medicine name: Dryopteris bissetiaha (Bak) C. Chr-Nephrodium bisseianum Bak; Source: be Dryopteridaceae plant Dryopteris bissetiaha (Bak) C. Chr-Nephrodium bisseianum Bak rhizome; Effect: heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing; Cure mainly: be used for seasonal pathogen sense, partial heat person, heating is heavy, aversion to cold is light, headache, pharynx are red, pharyngeal swelling, xerostomia and thirsty, red tongue, white and thin fur, floating pulse person; Meridian distribution of property and flavor: suffering, hardship, cold; " Xinhua's book on Chinese herbal medicine outline ": rhizome: the effect that heat-clearing and toxic substances removing is arranged; Be used to prevent influenza.
Radix Scutellariae, another name Radix Scutellariae, tsuchikane tea root; For labiate Radix Scutellariae (Scutellaria baicalensis Georgi), be used as medicine with root; Heat clearing and damp drying is arranged, and removing heat from blood is antiabortive, detoxicating functions; Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle; The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs; Originate in ground such as Hebei, Liaoning, Shaanxi, Shandong, the Inner Mongol, Heilungkiang.
Cortex Phellodendri, another name Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood are the dry bark of rutaceae wampee or Cortex Phellodendri; The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri "; Can be used as medicine, the nature and flavor bitter cold has heat clearing and damp drying, and pathogenic fire purging removes steams, and the effect of skin ulcer is treated in detoxifcation; Function with cure mainly: be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, the hectic fever due to YIN-deficiency consumptive fever, night sweat, the seminal emission, sore swollen toxin, eczema pruritus; The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire; Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.
Yellow Fructus Gardeniae, Chinese formal name used at school: Flos Gardeniae, have another name called Fructus Gardeniae, originate in China; Happiness warm and moist and sunny environment, more cold-resistant, anti-half is cloudy, is afraid of hydrops, requires loose, fertile and tart sandy loam; Genus rubia section, Gardenia Ellis, evergreen shrubs; Root, leaf, fruit all can be used as medicine, and the pathogenic fire purging relieving restlessness is arranged, clearing away heat and promoting diuresis, the effect of removing pathogenic heat from blood and toxic substance from the body; Effect cures mainly: clearing away lung-heat to relieve cough, and cooling blood for hemostasis cures mainly the cough due to lung-heat, and nose is coughed up phlegm, diseases such as toxic swelling.
Radix Isatidis, indigo-blue of another name commonly used, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) root, Radix Clerodenri Cyrtophylli are a kind of Chinese crude drugs, all produce all over China; Effect with heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving; Pharmacological action: 1. antibiosis and antiviral functions, 2. anti-leptospira effect, 3. Detoxication, 4. improve immunologic function, 5. antitumor action, 6. pair leukemia has effect.
Flos Lonicerae is the general designation of Chinese crude drug and plant, and the plant Flos Lonicerae has another name called Radix Ophiopogonis, is the perennial half evergreen winding bejuco of Caprifoliaceae; " Flos Lonicerae " one come from Compendium of Material Medica because Flos Lonicerae just opens and is white, after transfer yellow to, Flos Lonicerae hence obtains one's name; Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times, the sweet cold fragrance of its property, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance reaches thoroughly and can be eliminating evil, Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, as cards such as fever of the body, dermexanthesis, a speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.
YINZHEN, Chinese medicine " Herba Artemisiae Scopariae " are meant gathers the tender Herba Artemisiae Annuae of children down spring, and Herba Artemisiae Scopariae tool clearing away damp-heat, the effect of jaundice eliminating subcutaneous ulcer are the key medicine of treatment jaundice; Well-known doctor Huatuo had once compiled four words and had described Herba Artemisiae Scopariae: March Herba Artemisiae Scopariae Artemisia in April, pass with the descendant and make sure to keep in mind the jail, March, Herba Artemisiae Scopariae can be cured the disease, April, Herba Artemisiae Annuae burnt when bavin.
Fructus Forsythiae has another name called that Hemerocallis citrina Baroni bar, Fructus Forsythiae, green grass or young crops stick up, fall to sticking up, Huang Qidan etc., fruit medicine; Fructus Forsythiae is the Chinese medicine of heat-clearing and toxic substances removing, cures mainly calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, acute nephritis etc.; Pharmacological actions such as that Fructus Forsythiae has is antibiotic, heart tonifying, diuresis, town are told, diseases such as the acute anemopyretic cold of forsythia fruit for treating commonly used, carbuncle sore tumefacting virus, tuberculous lymphadenitis, urinary tract infection.
Radix Platycodonis, a kind of herbaceos perennial, the avette or ovum shape lanceolar of leaf, flower skipper or dark violet white; Chinese medicine, the root of Radix Platycodonis can be used as medicine, and effects such as eliminating phlegm and stopping cough, evacuation of pus are arranged; The kikyosaponin crude product has calmness, analgesia and central inhibitory action such as analgesic, and antiinflammatory and relieving cough and expelling phlegm, blood vessel dilating, blood pressure lowering, antiulcer action are arranged; Radix Platycodonis methanolic extract and thick Saponin gavage, and can strengthen mice carbon clearance speed. and the Radix Platycodonis skin also has phlegm-dispelling functions; Kikyosaponin has haemolysis.
The Radix Astragali has another name called Radix Astragali, is the general designation of plant and Chinese crude drug; The plant Radix Astragali originates in ground such as the Inner Mongol, Shanxi, Gansu, Heilungkiang, is state three level protecting plant; The Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting; The Radix Astragali contains various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper; The enhancing human body immunity function arranged, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Rhizoma Polygoni Cuspidati, another name piebaldism bamboo, acid tube bar, acid bucket Radix Crotalariae szemoensis, sour soup stalk, river muscle dragon, the speckle village, speckle cane root, Herba Rabdosiae Nervosae, yellow Radix Sanguisorbae; Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm; Be used for arthralgia, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
Astragalus polysaccharides is the dried powder that the dry root of the Radix Astragali forms through concentration extraction; Color and luster is palm fibre (Huang) brown powder, and it is little sweet to distinguish the flavor of, and tool draws moist; Suitable dosage form is drinking agent, spice agent, oral liquid, injection; Can be used as immunopotentiating agent or regulator, have effects such as antiviral, antitumor, defying age, radioprotective, anti-stress, antioxidation simultaneously.
The present invention compared with prior art has following characteristics:
Medicine of the present invention can effectively be prevented and treated pig blue-ear disease, use medicine of the present invention that better preventive effect is arranged in advance for the pig that does not have infected pigs's reproductive and respiratory syndrome especially, pig for moderate pig blue-ear disease symptom has good therapeutical effect, and it still has tangible preventive and therapeutic effect to swine influenza, pig streptococcicosis, pig erysipelas.
In order to be illustrated more clearly in the present invention, enumerate following examples, but it there is not any restriction to scope of invention.
The specific embodiment
A kind of medicine of preventing and treating pig blue-ear disease, it mainly is to be made by following bulk drugs: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of YINZHEN, 3.5～4.5 parts of the Radixs Astragali, 0.3～0.5 part of astragalus polysaccharides.
The better implement mode is: a kind of medicine of preventing and treating pig blue-ear disease, it mainly is to be made by following bulk drugs: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of YINZHEN, 3.5～4.5 parts of the Radixs Astragali, 1.5～2.5 parts of Rhizoma Osmundae, 0.8～1.2 part of Fructus Forsythiae, 1.5～2.5 parts of Radix Platycodoniss, 0.8～1.2 part of Rhizoma Polygoni Cuspidati, 0.3～0.5 part of astragalus polysaccharides.
Embodiment 1
Take by weighing 10 kilograms of Folium Pinis, 2 kilograms of Pericarpium Citri Reticulataes, 1 kilogram of Radix Ginseng, 1 kilogram of Radix Scutellariae, 1 kilogram of Cortex Phellodendri, 2 kilograms of Yellow Fructus Gardeniaes, 2 kilograms of Radix Isatidis, 0.3 kilogram in Radix Glycyrrhizae, 2 kilograms of Flos Loniceraes, 2 kilograms of YINZHEN, 4 kilograms of the Radixs Astragali, 0.4 kilogram of astragalus polysaccharides, these material compositions are through the weight after drying, be ground into 100～300 orders with super micron mill, mix homogeneously, pack with plastic bag sealing then, make the medicine of control pig blue-ear disease.
Using method: when at every turn feeding, according to forage volume, take by weighing the medicine (being the medicine that each ton feedstuff takes by weighing the control pig blue-ear disease that 10 to 20 kilograms present embodiment obtains) of the control pig blue-ear disease that the present embodiment of 1～2% feedstuff weight obtains, again with this medicine with an amount of water to mixing up, add then in the feedstuff, mix all, feed immediately, every day, sooner or later each was fed once, and 4～7 days is a course of treatment, fed course of treatment of this medicine every 40 days.
Prevent and treat contrast test: pig blue-ear disease occurs in hengyang, hunan province in 2008 county popular the time, the inventor has bought 60 of month big pigletss, be divided into two groups, every group 30, in the Hengyang County one pig Yang Zhi ?feed, breed place between two groups of pigs is separated with wire gauze, first group of 30 pig adds the medicine of the control pig blue-ear disease that 1～2% present embodiment obtains sooner or later during feeding respectively in feedstuff, used 7 days continuously, be first course of treatment, have 5 pigs pig blue-ear disease disease (slight dyspnea to occur, body temperature is elevated to 39.9 ℃ once in a while, diarrhoea is arranged once in a while), all 30 pigs are carried out PRRS serum detect, it is positive that the result detects the PRRS of 5 pigs, through the medicine of feeding present embodiment after 40 days again 7 days, be second course of treatment, have 3 pigs the reproductive and respiratory syndrome disease to occur, again through the medicine of feeding present embodiment in 40 days again 4 days, it is the 3rd course of treatment, when 5 months deliver for sale, the pig death condition does not appear, and the average weight of 30 pigs increases by 106 kilograms; 30 pigs of another group all beat reproductive and respiratory syndrome poison vaccine control, through 30 days, have 15 pigs pig blue-ear disease disease (dyspnea to occur, sometimes be ventral breathing, more than the loss of appetite, part fervescence to 40 ℃, the diarrhoea phenomenon is arranged), all 30 pigs are carried out PPRS serum to be detected, the result detects the PRRS positive rate and reaches 80%, after feeding through 2 months, 6 pig death is arranged again, having also, serious reproductive and respiratory syndrome disease (dyspnea appears in 16 pigs, sometimes be ventral breathing, loss of appetite, the part temperature of pig body is elevated to more than 40 ℃, part diarrhoea, gradual becoming thin, blepharoedema), during to 5 months, 8 pig death are arranged again, and 16 pig average weights that survive increase by 60 kilograms.
Embodiment 2
Take by weighing 9 kilograms of Folium Pinis, 1.5 kilograms of Pericarpium Citri Reticulataes, 0.8 kilogram of Radix Ginseng, 0.8 kilogram of Radix Scutellariae, 0.8 kilogram of Cortex Phellodendri, 1.5 kilograms of Yellow Fructus Gardeniaes, 1.5 kilograms of Radix Isatidis, 0.2 kilogram in Radix Glycyrrhizae, 1.5 kilograms of Flos Loniceraes, 1.5 kilograms of YINZHEN, 3.5 kilograms of the Radixs Astragali, 0.3 kilogram of astragalus polysaccharides; These material compositions are through the weight after drying, and are ground into 100～300 orders with super micron mill, and mix homogeneously is packed with plastic bag sealing then, make the medicine of control pig blue-ear disease.
Contrast control test: the inventor separates 60 100～110 jin pig and is divided into two groups and feeds the control reproductive and respiratory syndrome with wire gauze, result and embodiment 1 are close substantially: use 30 pigs of the medical treatment reproductive and respiratory syndrome of present embodiment dead pig phenomenon not occur, and use 30 pigs of injection pig blue-ear disease poison vaccine control reproductive and respiratory syndrome that 12 pig death are arranged.
Embodiment 3
Take by weighing 11 kilograms of Folium Pinis, 2.5 kilograms of Pericarpium Citri Reticulataes, 1.2 kilograms of Radix Ginseng, 1.2 kilograms of Radix Scutellariaes, 1.2 kilograms of Cortex Phellodendris, 2.5 kilograms of Yellow Fructus Gardeniaes, 2.5 kilograms of Radix Isatidis, 0.4 kilogram in Radix Glycyrrhizae, 2.5 kilograms of Flos Loniceraes, 2.5 kilograms of YINZHEN, 4.5 kilograms of the Radixs Astragali, 0.5 kilogram of astragalus polysaccharides; These material compositions are through the weight after drying, and are ground into 100～300 orders with super micron mill, and mix homogeneously is packed with plastic bag sealing then, make the medicine of control pig blue-ear disease.
Contrast control test: the inventor separates 60 150～200 jin pig and is divided into two groups and feeds the control reproductive and respiratory syndrome with wire gauze, the result is: use 30 pigs of the medical treatment reproductive and respiratory syndrome of present embodiment dead pig phenomenon not occur; And use 30 pigs of injection pig blue-ear disease poison vaccine control reproductive and respiratory syndrome that 8 pig death are arranged.
Embodiment 4
Take by weighing 10 kilograms of Folium Pinis, 2 kilograms of Pericarpium Citri Reticulataes, 1 kilogram of Radix Ginseng, 1 kilogram of Radix Scutellariae, 1 kilogram of Cortex Phellodendri, 2 kilograms of Yellow Fructus Gardeniaes, 2 kilograms of Radix Isatidis, 0.3 kilogram in Radix Glycyrrhizae, 2 kilograms of Flos Loniceraes, 2 kilograms of YINZHEN, 4 kilograms of the Radixs Astragali, 0.4 kilogram of astragalus polysaccharides, 2 kilograms of Rhizoma Osmundae, 1 kilogram of Fructus Forsythiae, 2 kilograms of Radix Platycodoniss, 1 kilogram of Rhizoma Polygoni Cuspidati; These material compositions are through the weight after drying, and are ground into 100～300 orders with super micron mill, and mix homogeneously is packed with plastic bag sealing then, make the medicine of control pig blue-ear disease.
Prevent and treat contrast test: pig blue-ear disease occurs in hengyang, hunan province in 2009 county popular the time, 6 sows that have been subjected to pregnancy that the inventor will culture, be divided into two groups, every group 3, in the Hengyang County one Yang Zhu ?feed, breed place between two groups of pigs is separated with wire gauze, first group of 3 pig adds the medicine of the control pig blue-ear disease that 1～2% present embodiment obtains sooner or later during feeding respectively in feedstuff, through the nursing of totally two courses of treatment in 80 days, successively give birth to 8,12,9 pigletss respectively, do not have the stillborn fetus phenomenon; And other three sows are adopted injection pig blue-ear disease poison vaccine control reproductive and respiratory syndrome, through 80 days nursing, have two sow successively to give birth to 8,7 pigletss respectively, and stillborn fetus is 1,4 respectively, wherein also has a sow death.
Embodiment 5
Take by weighing 9 kilograms of Folium Pinis, 1.5 kilograms of Pericarpium Citri Reticulataes, 0.8 kilogram of Radix Ginseng, 0.8 kilogram of Radix Scutellariae, 0.8 kilogram of Cortex Phellodendri, 1.5 kilograms of Yellow Fructus Gardeniaes, 1.5 kilograms of Radix Isatidis, 0.2 kilogram in Radix Glycyrrhizae, 1.5 kilograms of Flos Loniceraes, 1.5 kilograms of YINZHEN, 3.5 kilograms of the Radixs Astragali, 0.3 kilogram of astragalus polysaccharides, 1.5 kilograms of Rhizoma Osmundae, 0.8 kilogram of Fructus Forsythiae, 1.5 kilograms of Radix Platycodoniss, 0.8 kilogram of Rhizoma Polygoni Cuspidati; These material compositions are through the weight after drying, and are ground into 100～300 orders with super micron mill, and mix homogeneously is packed with plastic bag sealing then, make the medicine of control pig blue-ear disease.
Contrast control test: the inventor has done the contrast control the same with embodiment 2 and has tested, and the result is substantially the same manner as Example 1.
Embodiment 6 takes by weighing 11 kilograms of Folium Pinis, 2.5 kilograms of Pericarpium Citri Reticulataes, 1.2 kilograms of Radix Ginseng, 1.2 kilograms of Radix Scutellariaes, 1.2 kilograms of Cortex Phellodendris, 2.5 kilograms of Yellow Fructus Gardeniaes, 2.5 kilograms of Radix Isatidis, 0.4 kilogram in Radix Glycyrrhizae, 2.5 kilograms of Flos Loniceraes, 2.5 kilograms of YINZHEN, 4.5 kilograms of the Radixs Astragali, 0.5 kilogram of astragalus polysaccharides, 2.5 kilograms of Rhizoma Osmundae, 1.2 kilograms of Fructus Forsythiaes, 2.5 kilograms of Radix Platycodoniss, 1.2 kilograms of Rhizoma Polygoni Cuspidati; These material compositions are through the weight after drying, and are ground into 100～300 orders with super micron mill, and mix homogeneously is packed with plastic bag sealing then, make the medicine of control pig blue-ear disease.
Contrast control test: the inventor has done the contrast control the same with embodiment 3 and has tested, and the result is substantially the same manner as Example 1.
The present invention is not limited to and is used for preventing and treating pig blue-ear disease; the inventor is through many facts have proved; medicine of the present invention also has tangible preventive and therapeutic effect to swine influenza, pig streptococcicosis, pig erysipelas, just drops within the protection domain of invention so long as include the swine diseases control medicine of component of the present invention.
Claims (10)
1. medicine of preventing and treating pig blue-ear disease, it is characterized in that: it is made by following bulk drugs: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of Herba Artemisiae Scopariaes, 3.5～4.5 parts of the Radixs Astragali, 0.3～0.5 part of astragalus polysaccharides.
2. the medicine of control pig blue-ear disease according to claim 1 is characterized in that: it is made by following bulk drugs: 10 parts of Folium Pinis, 2 parts of Pericarpium Citri Reticulataes, 1 part of Radix Ginseng, 1 part of Radix Scutellariae, 1 part of Cortex Phellodendri, 2 parts of Yellow Fructus Gardeniaes, 2 parts of Radix Isatidis, 0.3 part in Radix Glycyrrhizae, 2 parts of Flos Loniceraes, 2 parts of Herba Artemisiae Scopariaes, 4 parts of the Radixs Astragali, 0.4 part of astragalus polysaccharides.
3. the medicine of control pig blue-ear disease according to claim 1 is characterized in that: it is made by following bulk drugs: 9 parts of Folium Pinis, 1.5 parts of Pericarpium Citri Reticulataes, 0.8 part of Radix Ginseng, 0.8 part of Radix Scutellariae, 0.8 part of Cortex Phellodendri, 1.5 parts of Yellow Fructus Gardeniaes, 1.5 parts of Radix Isatidis, 0.2 part in Radix Glycyrrhizae, 1.5 parts of Flos Loniceraes, 1.5 parts of Herba Artemisiae Scopariaes, 3.5 parts of the Radixs Astragali, 0.3 part of astragalus polysaccharides.
4. the medicine of control pig blue-ear disease according to claim 1 is characterized in that: it is made by following bulk drugs: 11 parts of Folium Pinis, 2.5 parts of Pericarpium Citri Reticulataes, 1.2 parts of Radix Ginseng, 1.2 parts of Radix Scutellariaes, 1.2 parts of Cortex Phellodendris, 2.5 parts of Yellow Fructus Gardeniaes, 2.5 parts of Radix Isatidis, 0.4 part in Radix Glycyrrhizae, 2.5 parts of Flos Loniceraes, 2.5 parts of Herba Artemisiae Scopariaes, 4.5 parts of the Radixs Astragali, 0.5 part of astragalus polysaccharides.
5. medicine of preventing and treating pig blue-ear disease, it is characterized in that: it is made by following bulk drugs: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of Herba Artemisiae Scopariaes, 3.5～4.5 parts of the Radixs Astragali, 0.3～0.5 part of astragalus polysaccharides, 1.5～2.5 parts of Rhizoma Osmundae, 0.8～1.2 part of Fructus Forsythiae, 1.5～2.5 parts of Radix Platycodoniss, 0.8～1.2 part of Rhizoma Polygoni Cuspidati.
6. the medicine of control pig blue-ear disease according to claim 5 is characterized in that: it is made by following bulk drugs: 10 parts of Folium Pinis, 2 parts of Pericarpium Citri Reticulataes, 1 part of Radix Ginseng, 1 part of Radix Scutellariae, 1 part of Cortex Phellodendri, 2 parts of Yellow Fructus Gardeniaes, 2 parts of Radix Isatidis, 0.3 part in Radix Glycyrrhizae, 2 parts of Flos Loniceraes, 2 parts of Herba Artemisiae Scopariaes, 4 parts of the Radixs Astragali, 0.4 part of astragalus polysaccharides, 2 parts of Rhizoma Osmundae, 1 part of Fructus Forsythiae, 2 parts of Radix Platycodoniss, 1 part of Rhizoma Polygoni Cuspidati.
7. the medicine of control pig blue-ear disease according to claim 5 is characterized in that: it mainly is to be made by following bulk drugs: 9 parts of Folium Pinis, 1.5 parts of Pericarpium Citri Reticulataes, 0.8 part of Radix Ginseng, 0.8 part of Radix Scutellariae, 0.8 part of Cortex Phellodendri, 1.5 parts of Yellow Fructus Gardeniaes, 1.5 parts of Radix Isatidis, 0.2 part in Radix Glycyrrhizae, 1.5 parts of Flos Loniceraes, 1.5 parts of Herba Artemisiae Scopariaes, 3.5 parts of the Radixs Astragali, 0.3 part of astragalus polysaccharides, 1.5 parts of Rhizoma Osmundae, 0.8 part of Fructus Forsythiae, 1.5 parts of Radix Platycodoniss, 0.8 part of Rhizoma Polygoni Cuspidati.
8. the medicine of control pig blue-ear disease according to claim 5 is characterized in that: it mainly is to be made by following bulk drugs: 11 parts of Folium Pinis, 2.5 parts of Pericarpium Citri Reticulataes, 1.2 parts of Radix Ginseng, 1.2 parts of Radix Scutellariaes, 1.2 parts of Cortex Phellodendris, 2.5 parts of Yellow Fructus Gardeniaes, 2.5 parts of Radix Isatidis, 0.4 part in Radix Glycyrrhizae, 2.5 parts of Flos Loniceraes, 2.5 parts of Herba Artemisiae Scopariaes, 4.5 parts of the Radixs Astragali, 0.5 part of astragalus polysaccharides, 2.5 parts of Rhizoma Osmundae, 1.2 parts of Fructus Forsythiaes, 2.5 parts of Radix Platycodoniss, 1.2 parts of Rhizoma Polygoni Cuspidati.
9. preparation method of preventing and treating the medicine of pig blue-ear disease, it is characterized in that: it comprises the steps:
One, takes by weighing raw material: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of Herba Artemisiae Scopariaes, 3.5～4.5 parts of the Radixs Astragali, 0.3～0.5 part of astragalus polysaccharides;
Two, will claim raw material pulverizing, mix homogeneously obtains preventing and treating the medicine of pig blue-ear disease.
10. preparation method of preventing and treating the medicine of pig blue-ear disease, it is characterized in that: it comprises the steps:
One, takes by weighing raw material: 9～11 parts of Folium Pinis, 1.5～2.5 parts of Pericarpium Citri Reticulataes, 0.8～1.2 part of Radix Ginseng, 0.8～1.2 part of Radix Scutellariae, 0.8～1.2 part of Cortex Phellodendri, 1.5～2.5 parts of Yellow Fructus Gardeniaes, 1.5～2.5 parts of Radix Isatidis, 0.2～0.4 part in Radix Glycyrrhizae, 1.5～2.5 parts of Flos Loniceraes, 1.5～2.5 parts of Herba Artemisiae Scopariaes, 3.5～4.5 parts of the Radixs Astragali, 0.3～0.5 part of astragalus polysaccharides, 1.5～2.5 parts of Rhizoma Osmundae, 0.8～1.2 part of Fructus Forsythiae, 1.5～2.5 parts of Radix Platycodoniss, 0.8～1.2 part of Rhizoma Polygoni Cuspidati;
Two, will claim raw material pulverizing, mix homogeneously obtains preventing and treating the medicine of pig blue-ear disease.
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| CN102370970B (en) * | 2011-10-12 | 2014-05-07 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine compound composition for treating blue ear disease of sows and preparation method thereof |
| CN102579622B (en) * | 2012-03-03 | 2014-06-25 | 贵州省畜牧兽医研究所 | Chinese herbal preparation for treating haemophilusparasuis and preparation method thereof |
| CN102727669B (en) * | 2012-06-20 | 2014-07-09 | 青岛绿曼生物工程有限公司 | Compound propolis composition used for treating swine erysipelas, and preparation method thereof |
| CN102961515B (en) * | 2012-11-22 | 2016-04-27 | 青岛绿曼生物工程有限公司 | Compound bee-glue composition for the treatment of swine erysipelas and preparation method thereof |
| CN104258047A (en) * | 2014-10-11 | 2015-01-07 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome |
| CN104798727B (en) * | 2015-04-30 | 2017-09-15 | 河南民正农牧股份有限公司 | The Chinese medicine composition and introduction method of a kind of overall antibody level of blue otopathy of holding |
| CN104800300B (en) * | 2015-05-14 | 2017-09-19 | 四川铁骑力士实业有限公司 | It is a kind of to prevent Chinese medicine composition of pig blue-ear disease and preparation method thereof |
| CN105053741A (en) * | 2015-09-23 | 2015-11-18 | 青岛华仁技术孵化器有限公司 | Feed capable of preventing and treating porcine reproductive and respiratory syndrome |
| CN106822870A (en) * | 2017-03-01 | 2017-06-13 | 中悦民安（北京）科技发展有限公司 | A kind of compound Chinese medicinal preparation and preparation method for preventing and treating swine influenza |
| CN107864870A (en) * | 2017-09-27 | 2018-04-03 | 胡征远 | A kind of method for cultivating zero-emission |
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