CN104286486B - For functional feed treating duck viral hepatitis and preparation method thereof - Google Patents

Abstract

The invention discloses for functional collaboration feedstuff treating duck viral hepatitis and preparation method thereof, wherein feedstuff includes following raw material: Semen Maydis, wheat bran, bean cake, assorted powder, stone powder, conch meal, Sal, Sorghum vulgare Pers., fish flour, crack rice, meat powder, rape cake, vitamine supplement and mineral additive; Its preparation method comprises the following steps: destruction step, batching step, granulation step and drying steps. The invention has the beneficial effects as follows: the feedstuff of the present invention contains the Chinese medicine additive of the effect with heat-clearing and toxic substances removing, promoting blood circulation and cooling blood, can strengthening vital QI to eliminate pathogenic factors, curative effect is better, drug residue free, the advantages such as cost price is cheap, Chinese medicine additive and other feedstuffs cooperate, interact, duck viral hepatitis can not only be treated, the nutritional need of duckling can also be met, being particularly well-suited to the nutritional need suffering from viral hepatitis duckling, body also can be played certain health-care effect by consumer after eating this type of duck meat.

Description

For functional feed treating duck viral hepatitis and preparation method thereof

Technical field

The present invention relates to bird feed, particularly to being used for functional feed treating duck viral hepatitis and preparation method thereof.

Background technology

It is scorching that duck viral hepatitis is called for short duck liver, is caused duckling a kind of to present the acute deadly infectious disease that hemorrhagic inflammation is feature with liver by virulent duck enteritis virus. Within 1945, finding primary disease called after I type duck viral hepatitis first in the U.S., nineteen sixty-five is found that duck viral hepatitis II type in Britain, within 1969, is found that duck viral hepatitis type III in the U.S.. At present, I type is worldwide distribution, and is once reported in the variant of India, Egypt and U.S.'s discovery I type DHV. II type and type III duck viral hepatitis are confined to Britain and the U.S. respectively, do not find variation strain. At home, duck viral hepatitis popular for the first time, it is again popular in China that phase early 1980s plays primary disease, and hereafter, various places epidemic situation is risen one after another, and epidemic situation can be controlled by the immunity of duck viral hepatitis I type attenuated vaccine; Since 1997, primary disease occurs more serious popular in certain areas, and its epidemic situation fully can not be controlled by standard duck viral hepatitis I type attenuated vaccine, suspects and has I type virulent duck enteritis virus variant to occur. Duck liver inflammation I type causes the Serious Mortality of duckling, and mortality rate is up to 90%, and middle one-tenth duck does not generally fall ill, and sick duckling is characterized by consciousness disorder, again and again twitches, and liver is mottled hemorrhage, gollbladder dilation, and bile color is thin out.

Duck viral hepatitis, virus I-type belongs to Picornaviridae, spherical in shape or class is spherical, and diameter is at 20-40NM, without cyst membrane, without coagulation, can in duck, chicken, goose embryo allantoic cavity propagation. Viral resistance is strong, can survive the long period in natural environment. DVH virus Type II belongs to Astrovirus, and DVH-III belongs to picornavirus. Without cross-protection between DVH three kinds of serotypes of virus. Virulent duck enteritis virus and DHB are without any dependency.

At present, China only finds duck liver inflammation I type, and the duckling group in 20 ages in days is more common in by primary disease type, and morbidity is anxious, propagates fast, and the course of disease is short, the features such as typical nervous symptoms, liver severe haemorrhage occurs, each contributes to make preliminary judgement. It should be noted that, in recent years clinically bigger age in days duck group or when having made the raw primary disease of the duck mass-sending of immunity inoculation, case often lacks typical pathological change, rarely seen liver enlargement, congestion, surface has tip telangiectasis to break and without serious mottled hemorrhage, easily cause Misdiagnosis, it is necessary to make a definite diagnosis through identification and isolation of pathogen. Diagnosis duck viral hepatitis should also be noted that and makees to differentiate with Riemerellosis Anatipestifer disease, duckling paratyphoid fever, fowl cholera, aspergillosis etc. clinically.

Epidemic characteristic: primary disease takes place mostly in 4～20 age in days ducklings, adult duck has resistance, chicken and the goose can not natural occurrence. Sick duck and band poison duck are major source of infection, mainly through digestive tract and respiratory tract infection. Feeding and management is bad, is deficient in vitamin and mineral, and duck shed is moist, crowded, and primary disease all can be promoted to occur. Primary disease betides the season of hatching duckling, once occur, propagates quickly in duckling group, and sickness rate is up to 100%

Pathological change: 1～4 day incubation period of primary disease, sudden onset, the course of disease is very brief. Sick just lethargy, does not eat, takes action dull, necking down, and wing is sagging, and eye semi-closure is comatose state, and some appearance are suffered from diarrhoea. Soon, there is nervous symptoms in sick duck, uneasy, movement disorder, and health swings to side, bipod generation spasm, death after a few hours. Dead front is to palintrope, in opisthotonus posture. The mortality rate of primary disease is variant because of the age, and the duckling within 1 week old may be up to 95%, and the duckling of 1～3 week old is less than 50%; The young duck of 4～5 week old is substantially not dead. Dissect visible features sexually transmitted disease (STD) to become at liver. Hepatomegaly, in yellowish red color or graniphyric, there are petechia and ecchymosis, gollbladder dilation in surface, is full of bile. Spleen is enlargement sometimes, the piebaldism of outward appearance also similar liver. Most kidneys are congested, swelling. Cardiac muscle is as boiled shape. Some case has in pericarditis, air bag slightly yellow transudate and cellulose flocculus. Liver edema, and have many needle points greatly to soybean grain massive hemorrhage point. Gollbladder dilation, is full of bile. Basis of microscopic observation, hepatocyte is vacuolation in initial infection, and Focal necrosis occurs in stage, and central nervous system is likely to there is vascular cuffing phenomenon. Splenomegaly, in mottling. Renal swelling is swollen, and blood vessel is obvious, in mulberry dendroid.

Primary disease is main infection duck under field conditions (factors), not infected chicken goose, throughout the year, different cultivars, sex duck all can infect, healthy duck is infected and popular morbidity by ill virus hepatitis duck and the feedstuff polluted with poison duck, water, pad grass, vehicle etc. by contacting, also by digestive tract and respiratory tract infection, the sickness rate of duckling and case fatality rate are all high, and the duckling case fatality rate in 1 week old may be up to 95%, and duck more than 1 monthly age then seldom falls ill death. Because feeding and management is not good at, being deficient in vitamin and mineral, duck shed is dark and damp, and the crowded grade of duck group all can promote primary disease to occur.

Western medical treatment: to the preventing and treating of duck liver inflammation I type it should be noted that following several respects: (1) introduces seedling, strict implement antisepsis system from healthy chicken flock. (2) immune protection: carry out immunity inoculation with duck viral hepatitis I type attenuated vaccine, becomes duck in first half of the month of laying eggs, and intramuscular injection 1-2 head part/only, lay eggs mid-term, intramuscular injection 2-4 head part/only. Duckling goes out after shell 1 age in days or 1 part of 7 age in days subcutaneous injections/only. In epidemic-stricken area, chickling also can be done passive immunity prevention in 1-2 age in days subcutaneous injection DVH-1 high immunity egg yolk or hyper-immune serum. (3) once break out primary disease, the sick duck of isolation immediately, and duck shed or waters are carried out thorough disinfection. To morbidity duckling group with standard DVH-1 high immunity yolk antibody injection for curing, 1-1.5 head part/only, note controlling secondary infection simultaneously. (4) to adopting standard DVH-1 attenuated vaccine or antibody to control bad sick duck group, getting rid of that this vaccine and antibody mass be bad and under the premise such as concurrent infection, answer isolation identification virus, inquire into situation about infecting about DVH-II type, type III infection and DVH-1 form variation strain, attempt using local strain to prepare vaccine and antibody, be used for preventing and treating. But, western medical treatment duck viral hepatitis scheme is single, and types of drugs is limited, and the course for the treatment of is longer, drug residue is relatively big, untoward reaction is more, and clinical efficacy is undesirable.

Chinese veterinarian thinks, duck viral hepatitis diseases caused by exogenous pathogenic factor six evil, and internal injury liver and gall taste involve the heart, kidney, causes accumulateing in weakened defensive QI, pathogenic heat, and battalion's the moon imbalance is sent out as this sick. Chinese traditional treatment duck viral hepatitis, from entirety, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, can for the unified treatment of the duck viral hepatitis of same pattern of syndrome, there is drug effect through focus, short treating period, evident in efficacy, drug residue free, low toxic and side effects, cheap, and the advantage of the immunity of organisms of duck can be increased.

Summary of the invention

The technical problem to be solved is to be in that to provide a kind of feedstuff containing the Chinese medicine additive for treating duck viral hepatitis, the Feed Energy containing this Chinese medicine additive is adopted to overcome the various defects of Chinese medicine of the prior art and Western medicine, there is heat-clearing and toxic substances removing, the effect of promoting blood circulation and cooling blood, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill duck, the course for the treatment of is shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, it is possible not only to effective symptom management, body also can be played the advantages such as certain health-care effect by consumer after eating this type of duck meat.

In order to solve above-mentioned technical problem, present invention provide for the functional feed for the treatment of duck viral hepatitis, wherein, described feedstuff includes following raw material: Semen Maydis, wheat bran, bean cake, assorted powder, stone powder, conch meal, Sal, Sorghum vulgare Pers., fish flour, crack rice, meat powder, rape cake, vitamine supplement and mineral additive.

In described feedstuff, the parts by weight of each raw material are: Semen Maydis 10-15 weight portion, wheat bran 10-18 weight portion, bean cake 8-12 weight portion, assorted powder 6-13 weight portion, stone powder 6-10 weight portion, conch meal 5-8 weight portion, Sal 1-2 weight portion, Sorghum vulgare Pers. 10-14 weight portion, fish flour 4-8 weight portion, 8-13 weight portion of cracking rice, meat powder 4-7 weight portion, rape cake 12-19 weight portion, vitamine supplement 1-2 weight portion and mineral additive 0.5-1 weight portion.

Described feedstuff also includes Chinese medicine additive, and in described feedstuff, the parts by weight of each raw material are: Semen Maydis 10-15 weight portion, wheat bran 10-18 weight portion, bean cake 8-12 weight portion, assorted powder 6-13 weight portion, stone powder 6-10 weight portion, conch meal 5-8 weight portion, Sal 1-2 weight portion, Sorghum vulgare Pers. 10-14 weight portion, fish flour 4-8 weight portion, 8-13 weight portion of cracking rice, meat powder 4-7 weight portion, rape cake 12-19 weight portion, vitamine supplement 1-2 weight portion, mineral additive 0.5-1 weight portion and Chinese medicine additive 6-10 weight portion.

In described feedstuff, the parts by weight of each raw material are: Semen Maydis 15 weight portion, wheat bran 12 weight portion, bean cake 8 weight portion, assorted powder 6 weight portion, stone powder 6 weight portion, conch meal 5 weight portion, Sal 1 weight portion, Sorghum vulgare Pers. 12 weight portion, fish flour 4 weight portion, 8 weight portions of cracking rice, meat powder 4 weight portion, rape cake 18 weight portion, vitamine supplement 1 weight portion and, mineral additive 0.5 weight portion and Chinese medicine additive 7 weight portion.

Described meat powder is one or more in beef powder, powder of pork, duck powdered meat and Carnis Gallus domesticus powder.

Described Chinese medicine additive includes following raw medicinal material: Lasiosphaera Seu Calvatia, Folium Mori, Flos Lonicerae, Rhizoma Cimicifugae, Radix Bupleuri, Fructus Tsaoko, Herba Artemisiae Annuae, Radix Dichroae, bean curd, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Imperatae, Cacumen Platycladi, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Pseudobulbus Cremastrae Seu Pleiones, Herba Salviae Chinensis, Radix Rhapontici, Ilex purpurea Hassk.[I.chinensis Sims, Herba Cayatiae Japonicae, Herba Saxifragae, Herba Portulacae, Herba Pteridis Multifidae and Radix Glycyrrhizae.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 10-30 weight portion, Folium Mori 15-35 weight portion, Flos Lonicerae 12-35 weight portion, Rhizoma Cimicifugae 10-25 weight portion, Radix Bupleuri 12-30 weight portion, Fructus Tsaoko 10-32 weight portion, Herba Artemisiae Annuae 10-28 weight portion, Radix Dichroae 7-13 weight portion, bean curd 15-38 weight portion, Radix Rehmanniae 10-25 weight portion, Radix Paeoniae Rubra 12-26 weight portion, Radix Ophiopogonis 10-24 weight portion, Rhizoma Imperatae 10-26 weight portion, Cacumen Platycladi 10-25 weight portion, Radix Scrophulariae 12-38 weight portion, Radix Arnebiae (Radix Lithospermi) 10-25 weight portion, Fructus Forsythiae 13-28 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8-12 weight portion, Herba Salviae Chinensis 12-28 weight portion, Radix Rhapontici 13-26 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 10-28 weight portion, Herba Cayatiae Japonicae 12-28 weight portion, Herba Saxifragae 6-14 weight portion, Herba Portulacae 10-20 weight portion, Herba Pteridis Multifidae 12-26 weight portion and Radix Glycyrrhizae 10-25 weight portion.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion and Radix Glycyrrhizae 20 weight portion.

In order to solve above-mentioned technical problem, present invention also offers the Chinese medicine additive for treating duck viral hepatitis, the preparation method of described Chinese medicine additive comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 82%～93% relative to 3～5 times of mixture, heat to boiling reflux 2～4 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 55～60 DEG C subsequently under vacuum 0.07～0.09Mpa is the mastic of 1.03～1.10, spray drying, the inlet temperature of spray dryer 165～170 DEG C, leaving air temp 70～75 DEG C, it is ground into powder subsequently, makes dried cream powder;

Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.1～0.3 times and 0.15～0.2 times in the dried cream powder obtained, make granule, dries in 45～50 DEG C, it is thus achieved that granule.

In order to solve above-mentioned technical problem, the preparation method that present invention also offers functional feed for treating duck viral hepatitis, described preparation method comprises the following steps:

(1) destruction step: weigh Semen Maydis, wheat bran, bean cake, rape cake, Sorghum vulgare Pers. by ratio of weight and the number of copies and crack rice, puts into pulverizer and carries out Crushing of Ultrafine, crosses 3.0mm sieve after pulverizing;

(2) batching step: weigh assorted powder, stone powder, conch meal, Sal, fish flour, meat powder, vitamine supplement, mineral additive and Chinese medicine additive according to ratio of weight and number, pulverize, with step (1), the fine powder obtained to mix, putting into mixer, mix homogeneously, incorporation time is 30-50s;

(3) granulation step: putting into granulator and granulate, pelleting temperature is 85-90 DEG C so that it is gelatinization degree reaches more than 92%.

(4) drying steps: pellet step (3) prepared, under the environment that temperature is 30-35 DEG C, carries out air-dry, pack.

The invention has the beneficial effects as follows: the feedstuff of the present invention contains and has heat-clearing and toxic substances removing, the Chinese medicine additive of the effect of promoting blood circulation and cooling blood, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill duck, there is the course for the treatment of shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, the advantages such as cost price is cheap, Chinese medicine additive and other feedstuffs cooperate, interact, duck viral hepatitis can not only be treated, the nutritional need of duckling can also be met, it is particularly well-suited to the nutritional need suffering from duck viral hepatitis duckling, body also can be played certain health-care effect by consumer after eating this type of duck meat.

Detailed description of the invention

Chinese medicine additive refers to takes as the leading factor with China the traditional theory of the physical property of the Nature Chinese herbal medicine (yin, yang, tremble with fear, freeze, temperature, heat), thing taste (sour, sweet, bitter, peppery, salty) and material relation and to raise and the subjects theory such as feed industry and technology are for support, the single and compound Chinese herbal medicine additive developed or intermixture. From modern pharmacology analysis, feed additive based on Chinese herbal medicine effective ingredients, there is the immunologic function and non-specific antimicrobial effect that regulate body, Chinese herbal medicine contains the bioactive substances such as the alkaloid of anti-antibacterial composition, polysaccharide, two class volatile oil, organic acid flavone and bioflavonoids, to regulating human body immune function, good effect of improving health conditions. It is reported, ward off more and there is promotion thymus reaction, stimulation reticuloendothelial cell raising specific antigen respond; Alkaloid can strengthen body fluid and cellular immune function, and the phagocytic function of stimulating expression of macrophage, two classes can strengthen the phagocytic function of reticuloendothelial system, and can generate by enhancing antibody, promote antigen antibody reaction and lymphocyte transformation organic acid, enteral can be regulated and prevent the breeding of noxious bacteria and improve the activity of enzyme, making animal body intracellular metabolic to be normally carried out. Folding Chinese medicine feed additive is divided not contain only a number of nutrient substance from the theory of modern nutriology, but also containing a number of unknown growth regulator and pigment, there is the biochemical reaction activating body directly or indirectly, strengthen biosynthesis effect, thus promoting the production performance of animal.

Chinese medicine additive of the present invention follows heat-clearing and toxic substances removing, promoting blood circulation and cooling blood is main, benefiting QI for strengthening the superficies is auxiliary principle, provide a kind of feedstuff for treating duck viral hepatitis, it includes Chinese medicine additive, and Chinese medicine additive includes following raw medicinal material: Lasiosphaera Seu Calvatia, Folium Mori, Flos Lonicerae, Rhizoma Cimicifugae, Radix Bupleuri, Fructus Tsaoko, Herba Artemisiae Annuae, Radix Dichroae, bean curd, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Imperatae, Cacumen Platycladi, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Pseudobulbus Cremastrae Seu Pleiones, Herba Salviae Chinensis, Radix Rhapontici, Ilex purpurea Hassk.[I.chinensis Sims, Herba Cayatiae Japonicae, Herba Saxifragae, Herba Portulacae, Herba Pteridis Multifidae, Radix Glycyrrhizae.

Wherein: Lasiosphaera Seu Calvatia can heat-clearing and toxic substances removing; Folium Mori are good at dissipating wind heat and letting out lung-heat, can only be used to the conjunctival congestion photophobia that wind heat causes, and can clearing away liver-fire, with Flos Lonicerae, Radix Bupleuri, Fructus Forsythiae, Radix Ophiopogonis compatibility with using; Rhizoma Cimicifugae delivers rash, heat-clearing and toxic substances removing, rises and lifts yang-energy, with Flos Lonicerae, Fructus Forsythiae, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Bupleuri compatibility with using; Radix Bupleuri is bitter, flat, enters percardium, liver, three burnt, gallbladder meridians, can induce sweat, bring down a fever, and dispersing the stagnated live-QI to relieve the stagnation of QI rises and lifts yang-energy, with Fructus Tsaoko, Herba Artemisiae Annuae, Radix Dichroae, Rhizoma Cimicifugae compatibility with using; The bean curd light diaphoretic prescription for delivering, can deliver outward heresy thoroughly, and the Radix Rehmanniae is sweet, bitter, cold, enters the heart, liver, kidney channel, can clearing away heat and cooling blood, promote the production of body fluid, with Radix Paeoniae Rubra, Radix Ophiopogonis, Flos Lonicerae, Fructus Forsythiae, Radix Scrophulariae, Rhizoma Imperatae, Cacumen Platycladi compatibility with using; Radix Arnebiae (Radix Lithospermi) is sweet, cold, enters the heart, Liver Channel, can removing heat from blood, removing toxic substances, rash, with Fructus Forsythiae, Flos Lonicerae, Radix Paeoniae Rubra compatibility with using; Flos Lonicerae is sweet, cold, enters lung, stomach, the heart, spleen channel, and heat-clearing and toxic substances removing, with Fructus Forsythiae, Radix Paeoniae Rubra, the Radix Rehmanniae, Radix Scrophulariae, Radix Glycyrrhizae compatibility; Pseudobulbus Cremastrae Seu Pleiones enters liver, stomach warp, and heat-clearing and toxic substances removing, with Herba Salviae Chinensis compatibility with using; Radix Rhapontici is bitter, cold, can heat-clearing and toxic substances removing, with Rhizoma Cimicifugae, Radix Scrophulariae compatibility; Ilex purpurea Hassk.[I.chinensis Sims can heat-clearing and toxic substances removing, cooling blood for hemostasis, with Herba Cayatiae Japonicae compatibility with use; Herba Saxifragae bitter, acrid, cold, can heat clearing away, removing heat from blood, removing toxic substances; Herba Portulacae heat clearing away, removing toxic substances, removing heat from blood; Herba Pteridis Multifidae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription. Entirely putting compatibility reasonable, rigorous, clinical efficacy is notable.

Now each taste medicine is described below:

Lasiosphaera Seu Calvatia: pungent, flat is nontoxic. It is mainly used as local hemostatic, double controls throat pain, aphonia etc. Traumatic hemorrhage, epistaxis, postextraction hemorrhage: Lasiosphaera Seu Calvatia tears epithelium off, take internal sponge floss sample thing compressing bleeding part or fill in nostril, filling gingiva place, have good hemostatic function. Carbuncle furuncle: Lasiosphaera Seu Calvatia spore powder, is in harmonious proportion with Mel and applies affected part. Chilblain: first embathed by affected part warm water, makes local rubescent, wipe dry after apply ointment or plaster Lasiosphaera Seu Calvatia by affected part size. Oral cavity hemorrhagic illness is had usefulness of significantly stopping blooding by lasiosphaera fenzlii Reics, not second to starch sponge or gelfoam, epistaxis is also effective. Staphylococcus aureus, bacillus pyocyaneus, Bacillus proteus and Diplococcus pneumoniae are had certain inhibitory action by lasiosphaera fenzlii Reics decoct, and minority pathomycete is also had inhibitory action.

Folium Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel. Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dry dense the boiling of person. Smooth file, takes such as red sugar, removes old wind and stagnated blood in big still. " " Japan hanako materia medica ": " profit the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and after steaming; Scolopendra stings snakeworm, and salt applies. " Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, qi-restoratives is moisturized; Cortex Mori energy eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, can be used for treatment conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.

Flos Lonicerae: cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat effect of wind, cure mainly disease under distension, epidemic febrile disease heating, the disease such as pyretic toxicity carbuncle and ulcer and tumor. It all has certain curative effect for diseases such as dizzy dizzy, xerostomia is made yearningly, hyperhidrosis unhappiness, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitiss. Flos Lonicerae tea has the weight losing function of uniqueness simultaneously, moreover it is possible to the pathogen suppressing with killing bottleneck throat, and old man and child are had infection effect. So, often take Flos Lonicerae and soak or decoct is conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the treatment of liver-heat disease regulating liver-QI pattern of fever hypertension and rehabilitation. Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, the phagocytic function of leukocyte can be promoted, multiple pyococcus and pathogenic entero becteria there is stronger bacteriostasis, including staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, newcastle, bacillus pyocyaneus, tubercule bacillus etc. In addition Flos Lonicerae also have function of gallbladder promoting to protect the liver, antioxidation, blood fat reducing, the effect such as central excitation.

Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung meridian, spleen channel, large intestine channel, stomach warp. " property of medicine opinion ": " control little eclampsia, infantile convulsion, the hot disease of seasonal epidemic pathogens. Controlling the swollen pain of ability to speak wind NI, root of the tooth floats rotten stench, pyretic toxicity pus and blood. Except cardiopulmonary pathogenic wind toxic heat is obstructed and constipated, aphtha, unhappy. Treat carbuncle, smallpox; Decocting silk floss is stained with and is wiped in skin ulcer. " Compendium of Material Medica: " speckle removing rash, clots absorbing blood, control sun and fall into dizzy fortune, and the empty pain of the breast side of body, after chronic diarrhea dysentery, weight, loses turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot. " function heat-clearing and toxic substances removing, rash. For measles without adequate eruption, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery.

Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, " Bencao Tujing " carries: " (Radix Bupleuri) is modern between passs, Shan, rivers and lakes, and shortcut all has it, with silver state person for winning. Life in February Seedling, very fragrant, stem is livid purple, and leaf is slightly purple like Folium Bambusae ... July opens Hemerocallis citrina Baroni ... root redness of the skin or complexion, strong like Radix Peucedani. Reed head has red hair such as rat-tail, and only nest elder is good. August in February adopts root. " have depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, dissipate effect of fire. Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, rise and lift yang-energy. Cure mainly: the heating that cures cold, cold and heat deficient fever. Children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, and uterus comes off, menoxenia. The caused heating such as typhoid fever, paratyphoid fever vaccine, escherichia coli liquid, fermented milk, yeast is had trivial solution heat effect by Radix Bupleuri volatile oil, and animal normal body temperature can be made to decline. Ankle joint caused by multiple proinflammatory agent is swollen and desmoplastic inflammation all has inhibitory action.

Fructus Tsaoko: acrid in the mouth, warm in nature, nontoxic; Enter spleen channel, stomach warp. Compendium of Material Medica: " Fructus Tsaoko, use same with the Rhizoma Anemarrhenae control subtertian malaria cold and heat, take the evil of its monoyin and monoyang unbiased victory, and it is cold that lid Fructus Tsaoko controls lunar only victory, and the fire that Rhizoma Anemarrhenae Zhi Yangming solely wins is also. " " herbal classic is met former ": " and except cold, dampness, dissipating depression of QI, relieving dyspepsia, expectorant on profit diaphragm, solve wheaten food, fish, all poison of meat. " dampness is except cold, eliminate the phlegm preventing the attack (or recurrence) of malaria, and help digestion relieving dyspepsia. Cure mainly malaria, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.

Herba Artemisiae Annuae: bitter, pungent, cold. Return liver, gallbladder meridian, three burnt, kidney channels. Function: clear deficiency-heat, removing heat from blood is except steaming, except steaming, preventing the attack (or recurrence) of malaria. Generate heat for pathogenic summer-heat, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat. This product clearing up internal heat by using drugs of bitter in taste and cold in nature, pungent perfume (or spice) dissipates thoroughly, kind makes a cloudy point latent heat thoroughly reach outer dissipating, and for fever due to yin deficiency key medicine, has expelling summer-heat in addition, cuts cruel merit. Arteether extracts neutral fraction and its rare alcohol extractum to Mus malaria, monkey malaria and people's malaria all in notable Antimalarial. Staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium are had stronger bacteriostasis by decocting liquid, and staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc. are also had certain inhibitory action. Ether extract, rare alcohol extractum and arteannuin to Mus malaria, monkey malaria, people's malaria all in notable Antimalarial. Arteannuin also can decreased heart rate, it is suppressed that myocardial contraction, reduces coronary flow.

Radix Dichroae: nature and flavor are pungent, cold, bitter; Return lung, liver, spleen, heart channel. " Bencao Tujing ": " Radix Dichroae, modern Jingxi district, Huaihe River, Zhejiang, prefecture, state, Hunan also have it. Haizhou person of going out, leaf like Folium catalpae bungei, eight chis, have premium white, sub green color, little like mountain chinaberry. Picking leaves in May, August adopts root, dries in the shade. This two taste is wanting most for the treatment of malaria. " " property of medicine opinion ": " and control all malarias, saliva of spitting, cold removing heat, tumor wart under item. " cure mainly phlegm retention in the heart; Malaria. Modern study shows that Radix Dichroae has Antimalarial, anti-ameba effect, refrigeration function etc.

Bean curd: this product is seed (i.e. Semen sojae atricolor) the germination person of legume soybean black. Sweet, flat; Enter spleen, stomach warp. For hygropyrexia, heat-damp in summer from the beginning of, heating, aversion to cold, heavy sensation of the body, uncomfortable in chest, greasy fur, retention of damp-heat in the interior, fever and irritability, uncomfortable in chest do not relax, the disease such as heavy sensation of the body bodily pain. The bean curd light diaphoretic prescription for delivering, can thoroughly deliver outward heresy, interior eliminate water wet, have table disease person concurrently for damp and hot. Bean curd is also good at sensible a surname's profit, for the humidifier fever such as hygropyrexia, heat-damp in summer.

The Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel. Shennong's Herbal: " sweet in the mouth, cold. Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat. Make soup and gather except cold and heat, eliminating impediment. Survivor is especially good. " heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis are invigorated blood circulation. The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment steaming bone and consumptive fever, throat pain, sputum mixed with blood.

Radix Paeoniae Rubra: nature and flavor, bitter, cold; Return Liver Channel. " herbal classic ": " main pathogen is suffered from abdominal pain, and except arthralgia due to stagnation of blood, broken heavily fortified point is long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating. " " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess fire, sending down the abnormal ascending QI, promoting the circulation of blood, removing blood stasis with potent drugs, dissipate clot, and only stomachache, moves back heat in blood, attack ulcerative carbuncle, control mange. " " property of medicine opinion ": " controlling pathogen of the lung gas, abdominal pain, vim and vigour are gathered, and logical a surname's internal organs gather around gas, control evil pain deteriorated blood, and time main, disease bone heat, strong the five internal organs, the kidney invigorating gas, control trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, repercussive blood, can lose pus. " energy blood stasis removing, pain relieving, removing heat from blood, detumescence. Can be used for controlling the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle. The stagnation of QI-blood cards such as epidemic febrile disease, heat enters nutrient blood, heating, crimson tongue, body send out macule, and bleeding due to blood-heat etc., it may also be used for amenorrhea, traumatic injury, sore and toxic.

Radix Ophiopogonis: property hardship sweet, micro-, it is slightly cold; GUIXIN, lung, stomach warp. There is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc. Clear the moon supporting lung stomach goes heart use more, and YIN nourishing clears away heart-fire the use that connects with the heart more. These product are sweet cold clear and rich, kind control deficiency of stomach-Yin, and dry tongue is thirsty, the indigestion and loss of appetite card such as not hungry. Deficiency of YIN dryness of the intestine is controlled, constipation person additionally, can also be used with. Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria has inhibitory action, can strengthen pituitary adrenal system function, improve organism adaptation ability. The diseases such as joining Radix Adenophorae (Radix Glehniae) Radix Ophiopogonis, lung stomach is ruled together, and has the cool stomach of lung heat clearing, the good effectiveness of YIN nourishing and the production of body fluid promoting, the few expectorant of the dry cough caused by lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin, dry laryngopharynx.

Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, bladder warp. " Bencao Tujing ": " Rhizoma Imperatae, the present has it everywhere. Spring sprouts, and cloth ground is such as pin, and between custom, the thatch pin of meaning, also can eat, very beneficial children's. Xia Sheng spends in vain, and fine so withered to the autumn, its root is to pure white, also very sweet and refreshing, adopts root June and uses. " Compendium of Material Medica: " the emesis all blood of nosebleed, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication. " having the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, being mainly used in lung stomach has the haematemesis of accumulated heat, hemoptysis, and damp invasion of lower energizer pents up the cards such as the hematuria of bladder, calentura excessive thirst taking fluids profusely, gastropyretic vomiting, jaundice due to damp-heat.

Cacumen Platycladi: " Amplification on Materia Medica addendum ": " how dry its property is for Cacumen Platycladi (Cacumen Biotae), the key medicine of nourishing YIN, of a specified duration it, big strengthening the spleen soil, to grow its lung. " " Bencao Jingshu ": " and Cacumen Platycladi, bitter in the mouth and tepor, justice should and in being slightly cold, therefore in all metrorrhagias of winner red in vain. With regard to QI invigorating of making light of one's life by commiting suicide, make us resistance to cold and summer-heat, be then slightly same as the property of cypress reality. Only granulation promoting is dried numbness, be its length solely arrogated to oneself also. " " Mingyi Bielu ": " main haematemesis, epistaxis, dysentery blood, metrorrhagia are red in vain. Make light of one's life by commiting suicide QI invigorating, make us resistance to cold and summer-heat, numbness of drying, granulation promoting. " additionally, still have antitussive, eliminate the phlegm, relieving asthma, the effect such as calm. Experiment in vitro shows, staphylococcus aureus, micrococcus catarrhalis, dysentery bacterium, Bacillus typhi, diphtheria corynebacterium etc. are all had inhibitory action by these product.

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, return lung, stomach, kidney channel. " detailed outline ": " kidney water is injured, Kidney-Yin fall, lonely sun unrooted, sends out as fire sick, and method should strengthen water with fire processed, therefore Radix Scrophulariae and the same merit of Radix Rehmanniae. Its scrofula that disappears also is dissipate fire, and it is that fire is sick that Liu keeps the truth tuberculosis. " " Records of Tradition Chinese and Western Medicine in Combination ": " Radix Scrophulariae, sweet and slightly bitter taste, many liquid cool in nature were the medicine of clear the kidney invigorating warp originally. Entering again lung with the bright heat of lung heat clearing man, detoxify the fire that disappears, and is suitable for pneumonopathy tuberculosis, cough due to lung-heat most. " " Japan hanako materia medica ": " controlling wind syndrome of head pyretic toxicity urticaria, qi-restoratives strains, the frightened agitation of the heart, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison. " there is clearing away heat and cooling blood, eliminating fire and detoxication, effect of YIN nourishing, cure mainly warm febrile disease and the card such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore is hindered in nutrient blood, fever of the body, excessive thirst, crimson tongue, a speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency not awake, Tianjin.

Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel, Compendium of Material Medica: " Radix Arnebiae (Radix Lithospermi), its merit is longer than removing heat from blood and promoting blood circulation, profit intestine and small intestine. Therefore varioliform exanthema is intended to out, heat in blood poison is contained, and stool closes puckery person and should use it, has gone out and the purple melena person of cutting also can use. If going out and red work, and white fall into convenience person, cut compatibility and incompatibility of drugs it. " " Bencao Jingshu ": " Radix Arnebiae (Radix Lithospermi) is the key medicine of removing heat from blood, therefore the gas of main trusted subordinate's pathogenic heat. " it is mainly used in that heat in blood poison is contained, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire etc. The ether of Radix Arnebiae (Radix Lithospermi), water, ethanol extraction all have certain antiinflammatory action. The oral refrigeration function that rabbit experiment heat pyrexia has mitigation of Radix Arnebiae (Radix Lithospermi) decoct, its extract and pigment composition also have slight refrigeration function.

Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian. " property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat. " Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti. Stick up greatly leaf long and narrow, such as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the person of not opening of Chinese toon reality, sticks up outstanding grass as room. On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi all like stick up greatly and little carefully, people from south, mountain also uses it. Only with sticking up greatly son under modern capital, without stem flower also. " have antibacterial, heart tonifying, diuresis, town the pharmacological action such as to tell, it is the Chinese medicine of heat-clearing and toxic substances removing, cures mainly calentura from the beginning of, the symptom such as anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus, its bacteriostasis and Flos Lonicerae broadly similar. Oleanolic acid contained by this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, it is prevented that haemolysis. Decoct has the town effect of telling, anti-liver injury effect.

Pseudobulbus Cremastrae Seu Pleiones: bitter, micro-pungent, cool. Dispersing swelling and dissipating binds, reduces phlegm, heat-clearing and toxic substances removing. Control carbuncle furuncle and phyma, laryngopharynx swelling and pain, sore throat, scrofula. Supplement to the Herbal: " vinegar mill applies it for main carbuncle skin ulcer fistula, scrofula tuberculosis etc. " Compendium of Material Medica: " main furuncle swells, counteracting toxic substances broken skin. Solve all poison, snakeworm, mad dog wound. " acute mastitis is swollen, carbuncle furunculosis, scrofula go through tuberculosis, for oral administration, external application, all can apply. For esophageal carcinoma, breast carcinoma, often and the fit applications such as Semen Impatientis, Rhizoma Pinelliae Preparata, Eupolyphaga Seu Steleophaga, Herba Salviae Chinensis; For lymph tumor, excision of benign breast, often and Thallus Laminariae (Thallus Eckloniae), Sargassum, Spica Prunellae, as fit applications such as shellfishes.

Herba Salviae Chinensis: acrid in the mouth, hardship, cold nature. Blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, mass dissipating and swelling eliminating. Curing mainly dysmenorrhea, damp-heat vaginal discharge, liver cirrhosis, hepatocarcinoma, have blood in stool, jaundice due to damp-heat, rheumatic ostalgia, traumatic injury wound is swollen. All herbal medicine, Jiangsu one band is scorching for treating the liver, facial paralysis, mastitis, carbuncle furuncle, the disease such as dysmenorrhea and osteodynia, and Jiangjin, Sichuan root is steep in wine for oral administration, can regulating menstruation and activating blood, Guangxi is used for curing rheumatism and skin ulcer scabies. Subsidiary formula Herba Salviae Chinensis is made medicinal, and foresight is in " the deficient beautiful letter of gold " of Zhang Zhongjing, and user was less later. But common effect still recorded by each book. Think that it is the medicine of " liver blood system ", " therefore controlling all disorders of blood ".

Radix Rhapontici: bitter in the mouth is salty, cold; Enter stomach, large intestine channel. Shennong's Herbal: " Radix Rhapontici bitter in the mouth is salty-cold. Main skin heat, evil wound, cellulitis hemorrhoid, lower milk ... one wild blue. Raw mountain valley. " " Bencao Jingshu ": " and Radix Rhapontici, hardship can be let out down, salty can softening the hard mass, cold can heat extraction, the cold and medicine of tonneau is also. Therefore main skin heat, malignant boil cellulitis hemorrhoid, arthralgia chiefly caused by damp pathogen, lower milk. " heat-clearing and toxic substances removing, evacuation of pus is subsided a swelling, and eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation. Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids. Radix Rhapontici water logging agent (1:3), in vitro has inhibitory action in various degree to the perhaps blue dermatophytes such as achorion, star-shaped nocardia. and Radix Rhapontici can be used for again various tumor clinically.

Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool. " Bencao Tujing ": " ashing, face cream is coated with it, controls chap chilblain special effect, the double scar defect that goes out. " Ilex purpurea Hassk.[I.chinensis Sims controls cough due to lung-heat, laryngopharynx swelling and pain, pyretic stranguria, dysentery. This product bitter cold, is good at clear purte the white and relieving heat toxin. Stop up on lung-fire, cough, pharyngalgia and anemopyretic cold; Or invade under pyretic toxicity, the puckery pain of dribbling urination, dysentery person, namely alone this product imitates.

Herba Cayatiae Japonicae: sour, bitter, cold, nontoxic. Such as the heart, liver, stomach warp. Tang Materia Medica: " main air is scorchingly hot swollen, You Dan, and snakebite is smash and applied and drink juice. " " vegetation is side just ": " heat-clearing and toxic substances removing, is coated with sore, and disappear tuberculosis, and nine fictitious gas infectionss, tonification is deficient. " heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, diuresis. For laryngopharynx swelling and pain, furuncle and phyma, carbuncle, furuncle, dysentery, hematuria, nebulousurine, traumatic injury, venom. With Plating, Herba Cayatiae Japonicae injection 1%, 10% concentration, proves that staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, card ground coccus, streptococcus pneumoniae, hemophilus influenza are all had inhibitory action. Herba Cayatiae Japonicae injection 1:10,1:100 dilution mixes injection chick embryo allantois intracavity with virus, and the anti--77-56-E2 in popularity cold virus A3/ Shanghai and the 68-1 strain of capital section have obvious inhibiting effect.

Herba Saxifragae: micro-bitter, acrid, cold; Enter lung, spleen, large intestine three warp. Compendium of Material Medica: " control pestilence, beat wine clothes. Vomiting and diarrhea people is used in life, ripe use then emesis profit. Control again ear, smash juice and drip it. " " the SHENGCAO property of medicine standby want ": " controlling in ear sudden high fever poison, redness is suppurated pain, beats juice and instills ear, or adds Borneolum Syntheticum and dissipate and heal. " dispel the wind, heat clearing away, removing pathogenic heat from blood and toxic substance from the body. Control rubella, eczema, otitis media, erysipelas, cough, spit blood, lung abscess, metrorrhagia, haemorrhoids. The fresh juice filtrate of isolated frog heart dropping Herba Saxifragae squeezing or 1:1 ethanol extract 0.01ml, all show certain cardiotonic. Anesthetized dog and conscious rabbits intravenous injection Herba Saxifragae ethanol extract 1ml/kg, present obvious diuresis.

Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel. Compendium of Material Medica: " dissipate blood detumescence, profit intestinal habitual abortion, detoxify treating stranguria, sweating due to debility after managing property. " " Kaibao Bencao ": not " clothes not white all the year round. Control ulcerative carbuncle, kill parasites. Raw juice of smashing takes, and when disliking thing under profit, removes tapeworm. " function heat-clearing and toxic substances removing, diuretic dries, and dissipates blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, and stop blooding removing heat from blood. Cure mainly dysentery, enteritis, nephritis, puerperal the diseases such as metrorrhagia, has blood in stool, mastitis. Dissipate blood detumescence, profit intestinal habitual abortion, detoxify treating stranguria, sweating due to debility after managing property.

Herba Pteridis Multifidae: hardship light, micro-is cool. " the SHENGCAO property of medicine is standby to be wanted ": " wash infantile malnutrition, furuncle, hemorrhoid, dissipate poison, apply skin ulcer. Controlling Serpentis and sting all poison, knife injury, energy hemostasia and promoting granulation, spring juice rectification takes, and slag applies affected part. Grinding into powder harvests and store controls pain due to disorder of QI. " " conventional Chinese herbal medicine handbook ": " heat clearing away, dampness removing, removing heat from blood. Control bacillary dysentery, enteritis, fever caused by exogenous pathogens, urinary tract infection, leucorrhea, parotitis, furuncle, eczema. " clearing away heat-damp and promoting diuresis, detoxify dysentery relieving, cooling blood for hemostasis. For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage, burn and scald are controlled in external.

Radix Glycyrrhizae: nature and flavor are sweet, flat. Enter spleen, stomach, lung meridian. " herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ". People's cloudy (no) " property of medicine opinion " says: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ". Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription. Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, loose stool of suffering from abdominal pain, extremity contraction urgency pain, hysteria, cough and asthma, laryngopharynx swelling and pain, ulcerative carbuncle swells and ache, infantile carbuncle, and medicine, alimentary toxicosis. For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong. Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has antiinflammatory and the function of resistance state reflection, therefore in doctor trained in Western medicine clinically mainly as demulcent. Relieving cough, eliminates the phlegm, and treats pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have desoxycortone class effect, and chronic adrenocortical hypofunction is had good effects; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.

Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment Chinese medicine additive 1

Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion, Radix Glycyrrhizae 20 weight portion.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 82% relative to 4 times of mixture, heat to boiling reflux 2 hours, filter, adopt percolation with the speed slowly percolation of 1ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.07Mpa is the mastic of 1.05, spray drying, the inlet temperature of spray dryer 165 DEG C, leaving air temp 70 DEG C, it is ground into powder subsequently, makes dried cream powder;

Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.1 times and 0.15 times in the dried cream powder obtained, make granule, dries in 45 DEG C, it is thus achieved that granule.

Embodiment 2 functional feed

Semen Maydis 15 weight portion, wheat bran 12 weight portion, bean cake 8 weight portion, assorted powder 6 weight portion, stone powder 6 weight portion, conch meal 5 weight portion, Sal 1 weight portion, Sorghum vulgare Pers. 12 weight portion, fish flour 4 weight portion, 8 weight portions of cracking rice, meat powder 4 weight portion, rape cake 18 weight portion, vitamine supplement 1 weight portion and, mineral additive 0.5 weight portion and Chinese medicine additive 7 weight portion; Wherein Chinese medicine additive is the Chinese medicine additive granule that embodiment 1 prepares; Described meat powder is beef powder.

Its preparation method comprises the following steps:

(1) destruction step: weigh Semen Maydis, wheat bran, bean cake, rape cake, Sorghum vulgare Pers. by ratio of weight and the number of copies and crack rice, puts into pulverizer and carries out Crushing of Ultrafine, crosses 3.0mm sieve after pulverizing;

(2) batching step: weigh assorted powder, stone powder, conch meal, Sal, fish flour according to ratio of weight and number, crack rice, meat powder, vitamine supplement and mineral additive, pulverize, with step (1), the fine powder obtained to mix, putting into mixer, mix homogeneously, incorporation time is 40s;

(3) granulation step: putting into granulator and granulate, pelleting temperature is 85 DEG C so that it is gelatinization degree reaches more than 92%.

(4) drying steps: pellet step (3) prepared, under the environment that temperature is 35 DEG C, carries out air-dry, pack.

The toxicity test of Chinese medicine additive

1, trial drug: by Lasiosphaera Seu Calvatia 20g, Folium Mori 25g, Flos Lonicerae 30g, Rhizoma Cimicifugae 15g, Radix Bupleuri 20g, Fructus Tsaoko 15g, Herba Artemisiae Annuae 18g, Radix Dichroae 7g, bean curd 28g, Radix Rehmanniae 15g, Radix Paeoniae Rubra 16g, Radix Ophiopogonis 14g, Rhizoma Imperatae 16g, Cacumen Platycladi 15g, Radix Scrophulariae 18g, Radix Arnebiae (Radix Lithospermi) 15g, Fructus Forsythiae 20g, Pseudobulbus Cremastrae Seu Pleiones 8g, Herba Salviae Chinensis 18g, Radix Rhapontici 16g, Ilex purpurea Hassk.[I.chinensis Sims 18g, Herba Cayatiae Japonicae 18g, Herba Saxifragae 6g, Herba Portulacae 15g, Herba Pteridis Multifidae 16g and Radix Glycyrrhizae 20g is mixed in proportion, add the ethanol that determining alcohol is 90% relative to mixture quality 2 times, it is heated to reflux 2 hours, extract, filter and obtain the first extracting solution, filter the medicinal residues obtained and add the ethanol that determining alcohol is 90% relative to described medicinal residues quality 1 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution, first extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream, it is placed in super micron mill by the dry cream obtained to pulverize 2 hours, pulverizes, sieve, it is thus achieved that the micropowders of 300 orders, the micropowders of acquisition will add the starch relative to its quality 2 times, mixing, it is thus achieved that powder.

2, test method: application NIH mice 20, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test. Mice is randomly divided into two groups, often group 10, i.e. matched group and administration group, fasting 12 hours before experiment; Trial drug is dissolved in water, (concentration is 6.5g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.5g crude drug/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll. Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal. Therefore the Chinese medicine additive acute toxicity of the present invention is low, clinical drug safety.

Contrast test

Purchase 1 age in days duckling 5 batches without Shandong Province's cultivation of maternal antibody, totally 1000 ducklings. 1st batch 80, measure for virus lethal dose. 2nd batch 160, it is randomly divided into 4 groups, often group 40, i.e. functional feed group, Western medicine conventional feed group, infection matched group and blank group.

Virulent duck enteritis virus serum I type is provided by China Veterinery Drug Inspection Office.

Test article: embodiment 2 functional feed and the oral liquid conventional feed that addition Western medicine amantadine content is 0.2mg/mL.

Minimum lethal dose measures: with 1 age in days without maternal antibody duckling 80, raises to the 7th day, carries out minimum lethal dose mensuration with the DHV allantoic fluid through Embryo Gallus domesticus rejuvenation. Result of the test minimum lethal dose is that allantoic fluid 100 times dilution 0.22mL/ is only administered orally.

Inoculation: with 7 ages in days without maternal antibody duckling, according to minimum lethal dose measurement result, carry out formal inoculation test. Blank group not virus inoculation allantoic fluid, the oral minimum lethal dose after measured of all the other ducks is the viral allantoic fluid 0.22mL of 1: 100 dilution.

Treatment: functional feed group normally feeds with embodiment 2 functional feed after 2 days at virus inoculation, is used in conjunction 5d.

Western medicine conventional feed group, after virus inoculation 2 days, carries out right mind by conventional feed, is the oral liquid of 0.2mg/mL with amantadine content simultaneously, gavages 2.5mL every time, be used in conjunction 5d.

Blank group need not any Drug therapy, only feed conventional feed.

Infect matched group need not any Drug therapy, a feeding conventional feed.

Result of the test

After inoculating virulent duck enteritis virus, morbidity duckling occurs that symptom is as follows: sick duck finding symptom mainly has: spirit is depressed, and appetite is gradually reduced, and feather is slightly disorderly unglazed, instability of gait, two wing shakes, dyspnea, diarrhoea, row's yellow or celadon loose stool, there is nervous symptoms before on one's deathbed in the sick duck of part, the symptoms such as opisthotonus occurs, is namely judged as duck viral hepatitis.

Record the survival rate after postvaccinal morbidity number and treatment and mortality rate, referring to table 1. Survival duckling sampling is carried out chest muscle meat detection: moisture oven method measures, and (80 ± 2) DEG C dry to constant weight; The mensuration of crude protein adopts combustion method (GB/T5009.5-2010); Crude fat is with Soxhlet extraction (GB/T5009.6-2003); Crude fibre is measured according to GB/T5009.6-2003; Aminoacid adopts automatic amino acid analyzer to be measured (GB/T5009.124-2003), referring to table 2.

The therapeutic effect synopsis that table 1 is respectively organized

Group	Morbidity number	Survival number	Death toll	Survival rate	Mortality rate
						Functional feed group	38	38	0	100%	0%
Western medicine conventional feed group	38	20	18	52.63%	47.37%
						Blank group	0	40	0	100%	0%
Infect matched group	40	0	40	0%	100%

As can be seen from Table 1, after inoculation infectious hepatitis of duck virus, functional feed group, Western medicine conventional feed group and infection matched group, incidence in various degree all occurs. Through feeding, the treatment survival rate of functional feed group is higher than western medicine group, higher than infecting matched group. Therefore, it follows that the functional feed of the present invention, treat duck viral hepatitis, effective, determined curative effect.

Table 2 is the chest muscle meat testing result contrast table of each group

Nutrition contrasts	Functional feed group	Western medicine conventional feed group	Blank group	Infect matched group
					Moisture %	72.11±1.21	63±1.32	63±1.23	---
Crude protein %	17.43±0.76	15±0.34	14±0.43	---
					Crude fibre %	0.13±0.03	0.11±0.02	0.01±0.01	---
Crude fat %	1.24±0.34	1.31±0.21	1.30±0.34	---

As can be seen from Table 2, the duckling chest muscle meat of functional feed group is better than the combination of Western medicine conventional feed and blank group. Both it is known that the functional feed of the present invention, while treatment duck viral hepatitis, meat nutrition is also improved.

In sum, the functional feed of the present invention, treat duck viral hepatitis, good effect, determined curative effect, and also improve the meat nutrition of duck meat, after edible, body is more had health-care effect, and has no side effect.

Model case: Heze city of Shandong province duck raiser, cultivates 800 ducklings, duck viral hepatitis symptom occurs: spirit is depressed, appetite is gradually reduced, feather is slightly disorderly unglazed, instability of gait, two wing shakes, dyspnea, diarrhoea, ash discharge green loose stool, take the tissue smear such as duck liver, spleen of dying of illness, after dyeing with Wright Stain, the dialister bacterium of the dense dye in visible the two poles of the earth, is namely judged as duck viral hepatitis. Selecting 300 ducklings, adopt the functional feed of embodiments of the invention 2 normally to feed, treat 5,299 ducklings are cured in survival, dead 1, survival rate 99.67%.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.

Claims (5)

1. for treating the functional feed of duck viral hepatitis, it is characterized in that, in described feedstuff, the parts by weight of each raw material are: Semen Maydis 10-15 weight portion, wheat bran 10-18 weight portion, bean cake 8-12 weight portion, assorted powder 6-13 weight portion, stone powder 6-10 weight portion, conch meal 5-8 weight portion, Sal 1-2 weight portion, Sorghum vulgare Pers. 10-14 weight portion, fish flour 4-8 weight portion, 8-13 weight portion of cracking rice, meat powder 4-7 weight portion, rape cake 12-19 weight portion, vitamine supplement 1-2 weight portion, mineral additive 0.5-1 weight portion and Chinese medicine additive 6-10 weight portion;

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 10-30 weight portion, Folium Mori 15-35 weight portion, Flos Lonicerae 12-35 weight portion, Rhizoma Cimicifugae 10-25 weight portion, Radix Bupleuri 12-30 weight portion, Fructus Tsaoko 10-32 weight portion, Herba Artemisiae Annuae 10-28 weight portion, Radix Dichroae 7-13 weight portion, bean curd 15-38 weight portion, Radix Rehmanniae 10-25 weight portion, Radix Paeoniae Rubra 12-26 weight portion, Radix Ophiopogonis 10-24 weight portion, Rhizoma Imperatae 10-26 weight portion, Cacumen Platycladi 10-25 weight portion, Radix Scrophulariae 12-38 weight portion, Radix Arnebiae (Radix Lithospermi) 10-25 weight portion, Fructus Forsythiae 13-28 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8-12 weight portion, Herba Salviae Chinensis 12-28 weight portion, Radix Rhapontici 13-26 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 10-28 weight portion, Herba Cayatiae Japonicae 12-28 weight portion, Herba Saxifragae 6-14 weight portion, Herba Portulacae 10-20 weight portion, Herba Pteridis Multifidae 12-26 weight portion and Radix Glycyrrhizae 10-25 weight portion.

2. the functional feed for treating duck viral hepatitis according to claim 1, it is characterized in that, in described feedstuff, the parts by weight of each raw material are: Semen Maydis 15 weight portion, wheat bran 12 weight portion, bean cake 8 weight portion, assorted powder 6 weight portion, stone powder 6 weight portion, conch meal 5 weight portion, Sal 1 weight portion, Sorghum vulgare Pers. 12 weight portion, fish flour 4 weight portion, 8 weight portions of cracking rice, meat powder 4 weight portion, rape cake 18 weight portion, vitamine supplement 1 weight portion, mineral additive 0.5 weight portion and Chinese medicine additive 7 weight portion.

3. the functional feed for treating duck viral hepatitis according to claim 1, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion and Radix Glycyrrhizae 20 weight portion.

4. the functional feed for treating duck viral hepatitis according to claim 3, it is characterised in that the preparation method of described Chinese medicine additive comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 82%～93% relative to 3～5 times of mixture, heat to boiling reflux 2～4 hours, filter, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 55～60 DEG C subsequently under vacuum 0.07～0.09Mpa is the mastic of 1.03～1.10, spray drying, the inlet temperature of spray dryer 165～170 DEG C, leaving air temp 70～75 DEG C, it is ground into powder subsequently, makes dried cream powder;

Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.1～0.3 times and 0.15～0.2 times in the dried cream powder obtained, make granule, dries in 45～50 DEG C, it is thus achieved that granule.

5. the preparation method of the functional feed for treating duck viral hepatitis according to any one of claim 1-4, it is characterised in that described preparation method comprises the following steps:

(1) destruction step: weigh Semen Maydis, wheat bran, bean cake, rape cake, Sorghum vulgare Pers. by ratio of weight and the number of copies and crack rice, puts into pulverizer and carries out Crushing of Ultrafine, crosses 3.0mm sieve after pulverizing;

(2) batching step: weigh assorted powder, stone powder, conch meal, Sal, fish flour, meat powder, vitamine supplement, mineral additive and Chinese medicine additive according to ratio of weight and number, pulverize, with step (1), the fine powder obtained to mix, putting into mixer, mix homogeneously, incorporation time is 30-50s;

(3) granulation step: putting into granulator and granulate, pelleting temperature is 85-90 DEG C so that it is gelatinization degree reaches more than 92%;

(4) drying steps: pellet step (3) prepared, under the environment that temperature is 30-35 DEG C, carries out air-dry, pack.