CN104383288A - Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia - Google Patents

Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia Download PDF

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CN104383288A
CN104383288A CN201410750113.3A CN201410750113A CN104383288A CN 104383288 A CN104383288 A CN 104383288A CN 201410750113 A CN201410750113 A CN 201410750113A CN 104383288 A CN104383288 A CN 104383288A
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weight portion
herba
pharmaceutical composition
parts
fructus
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黄河
李鑫
燕磊
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Shandong New Hope Liuhe Group Co Ltd
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Shandong New Hope Liuhe Group Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention provides a pharmaceutical composition for treating bovine pneumonia and a preparation method of the pharmaceutical composition for treating bovine pneumonia. The pharmaceutical composition is prepared from the following medicinal raw material: houttuynia cordata, triumfetta rhomboidea, fructus schizandrae, dicliptera chinensis, uncaria, sweet wormwood, almond, tussilago farfara, radix isatidis, rhizoma anemarrhenae, caulis perllae, zehneria mysorensis arn, lygodium japonicum, Japanese cayratia herb, Japanese ardisia, folium eriobotryae, fructus chebulae, hypericum japonicum, puffball, tamarix chinensis, licorice root, delavay falsepanax herb, fragile blueberry, Chinese white birch sap, water-dragon, Yunnan pleione tuber, peganum harmala and herb of hairystalk loosestrife. The pharmaceutical composition for treating bovine pneumonia can be used for improving the disease resistance of the bovine and boosting the immunity of the bovine while achieving the effects of clearing away heat and toxic materials, freeing lungs and relieving asthma, has the advantages of being purely natural, free of disease resistance, residues and toxic and side effects, strong in pertinence, remarkable in curative effect by directly reaching lesion, and the like. Moreover, the pharmaceutical composition has a function of promoting growth of cow to some extent.

Description

A kind ofly be used for the treatment of pharmaceutical composition of pulmonis Bovis seu Bubali inflammation and preparation method thereof
Technical field
The present invention relates to domestic animal medicine technical field, be particularly a kind ofly used for the treatment of pharmaceutical composition of pulmonis Bovis seu Bubali inflammation and preparation method thereof.
Background technology
Pulmonis Bovis seu Bubali inflammation refers to the substantive inflammation of the lung of cattle, and usually with bronchitis and pleuritis, clinical signs increases number, cough for breathing, and auscultation has abnormal breathing sound.
The cause of disease: pneumonia type Bacillus pasteurii disease (transporting hot) is one of modal pneumonia of cattle, caused by pasteurella haemolytica and pasteurella multocida, influenza virus may be a kind of inducement, the endemicity pneumonia of calf is by some different virus, as cold virus, adenovirus etc., chlamydia, Mycoplasma cause, and have pasteurellosis bacillus, suppurative corynebacterium and streptococcus secondary infection in addition.Cattle infectious pleurisy is caused by Mycoplasma mycoides.The viviparous reticulum nematicide of cattle can cause nematicide property pneumonia, and tubercule bacillus can cause tuberculous pneumonia.
Symptom: tachypnea is the fundamental symptoms of early stage pneumonia.When most of lung tissue is contaminted, when can not play gas exchange action, there is dyspnea, cough different with the character of infringement, as bronchopneumonia has painful cough caused by pathogenic damp, the normal dry cough that paroxysm is violent again and again of interstitial pneumonia, auscultation chest before and after cough, can find in air flue and have transudate, when most of lungs are ill, mucosa can cyanosis, and upper respiratory tract infection nose juice is many, when accumulating dense thick or corrupt pus in air flue, breath has rotten odor.In bronchopneumonia and interstitial pneumonia early stage stage of congestion, alveolar noise strengthens, and has moist rale, have ear-piercing bronchophony during interstitial pneumonia during bronchopneumonia, can only hear bronchophony during pulmonary consolidation on sick lung, bronchopneumonia district surrounding can be heard moist rale and twist with the fingers the property sent out rale.During pulmonary consolidation, hear sounds strengthens, and can produce pleura crunch with during pleuropneumonia.According to the degree of pneumonia morbidity, have heating in various degree, anorexia, depressed and be reluctant to couch, as being viral, chlamydia infection, conventional sulfanilamide, antibiotic therapy are invalid.
Diagnosis: according to the change of symptom, body temperature, breathing and auscultation, pneumonia is not difficult to diagnose, but to want and congestive heart failure, anemia latter stage, the dyspnea of organizing poisoning, heating and acidosis to cause distinguish dyspneic, the dyspnea of these diseases is without typical auscultation of lung sound, pulmonary edema, pulmonary congestion, emphysema may be mistaken as pneumonia, but usually do not generate heat without toxemia.Upper respiratory disease also has respiratory variations, cough and abnormal auscultatory sound, but sound when air-breathing obviously, and during pneumonia, exhale and inhale two benches and larynx all can occur and bronchitis is coughed frequently, this cough pinches larynx by pressure and trachea has lured.
Treatment: the possibility considering infectious disease, sick cattle should be isolated, and keep a close eye on the situation of other cattle, to find early, veterinary arts person, according to experience in the past, uses and thinks the medicines such as effective antibiotics and sulfanilamide, is in harmony works as selected, general very soon can rehabilitation, some case needs medication every day until return to one's perfect health.Endodontic failure is not often because having Timeliness coverage ill domestic animal, pathogenic bacteria has drug resistance or underdosage to antibiotics or sulfanilamide, or without other supporting treatments, the pneumonia caused because of virus and Mycoplasma Mycoides Infection there is no effective therapy, but antibiotics or sulfa drugs can prevent Secondary bacterial infections.Can cure by oxygen therapy as having ready conditions, use eliminate the phlegm, antitussive and Chinese herbal medicine, the rehabilitation of cattle can be promoted.But current western medical treatment side effect is larger, especially some antibiotic application, cause the Drug resistance of ill cattle more and more stronger, and the impact itself also having certain Chengdu on cattle, affect meat flavor, can reduce economic benefit further.
Motherland's traditional Chinese veterinary medicine thinks that pneumonia causes a name of disease, is equivalent to the lung abscess in the traditional Chinese medical science.Refer to because pyretic toxicity stasis is in lung, so that the raw skin ulcer of the lobe of the lung, meat deteriorated blood is rotten, forms pus infections, and to generate heat, cough, chest pain, coughs up and tell stench turbid expectorant, very then coughs up a kind of disease that vomiting pus bloody sputum is main clinical manifestation.Primary disease is by being invaded by exogenous pathogen, and enemy intrusion or invasion is in lung, or expectorant phlogiston is contained, and steams the lungs that burn, and stops up blood stasis, accumulate and lead to carbuncle with pyrogenicity, and blood loses meat corruption pus.
Select traditional Chinese medical science mode to treat pulmonis Bovis seu Bubali inflammation, there is certain advantage.
Summary of the invention
Technical problem to be solved by this invention is to provide and is a kind ofly used for the treatment of pharmaceutical composition of pulmonis Bovis seu Bubali inflammation and preparation method thereof, while this pharmaceutical composition has heat-clearing and toxic substances removing, depressed lung-energy dispersing function, the resistance against diseases of cattle can be strengthened, strengthen its immunity, in treatment cattle pneumonia disease, there is pure natural, have no drug resistance, noresidue, have no side effect, evident in efficacy, specific aim strong, through focus, the not easily advantageous feature such as recurrence, and have certain facilitation to the growth of cattle.
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation, wherein, described pharmaceutical composition comprises following raw medicinal material: Herba Houttuyniae, thorn capsule fiber crops, Fructus Schisandrae Chinensis, Herba Diclipterae Chinensis, Ramulus Uncariae Cum Uncis, Herba Artemisiae Annuae, Semen Armeniacae Amarum, Flos Farfarae, Radix Isatidis, the Rhizoma Anemarrhenae, Caulis Perillae, wild Fructus Momordicae charantiae, Spora Lygodii, Herba Cayatiae Japonicae, PINGDIMU, Folium Eriobotryae, Fructus Chebulae, Herba Hyperici Japonici, Lasiosphaera Seu Calvatia, Ramulus et Folium Tamaricis, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi, Folium Vaccinii Fragilis, Sucus Betulae platyphyllae, Herba Jussiaeae Repentis, Rhizoma Pleiones Yunnanensis, Semen pegani harmalae and Herba lysimachiae capillipedis.
Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material can be: Herba Houttuyniae 35-40 weight portion, thorn capsule fiber crops 10-20 weight portion, Fructus Schisandrae Chinensis 25-30 weight portion, Herba Diclipterae Chinensis 15-25 weight portion, Ramulus Uncariae Cum Uncis 10-15 weight portion, Herba Artemisiae Annuae 10-14 weight portion, Semen Armeniacae Amarum 20-25 weight portion, Flos Farfarae 10-20 weight portion, Radix Isatidis 15-20 weight portion, Rhizoma Anemarrhenae 10-16 weight portion, Caulis Perillae 15-20 weight portion, wild Fructus Momordicae charantiae 25-30 weight portion, Spora Lygodii 10-20 weight portion, Herba Cayatiae Japonicae 15-20 weight portion, PINGDIMU 15-25 weight portion, Folium Eriobotryae 10-20 weight portion, Fructus Chebulae 15-20 weight portion, Herba Hyperici Japonici 10-20 weight portion, Lasiosphaera Seu Calvatia 15-20 weight portion, Ramulus et Folium Tamaricis 10-20 weight portion, Radix Glycyrrhizae 20-30 weight portion, Herba seu Radix Nothopanacis delavayi 10-14 weight portion, Folium Vaccinii Fragilis 25-30 weight portion, Sucus Betulae platyphyllae 4-10 weight portion, Herba Jussiaeae Repentis 15-20 weight portion, Rhizoma Pleiones Yunnanensis 20-25 weight portion, Semen pegani harmalae 1-4 weight portion and Herba lysimachiae capillipedis 10-15 weight portion.
Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material can also be: Herba Houttuyniae 40 weight portion, thorn capsule fiber crops 20 weight portions, Fructus Schisandrae Chinensis 30 weight portion, Herba Diclipterae Chinensis 25 weight portion, Ramulus Uncariae Cum Uncis 15 weight portion, Herba Artemisiae Annuae 14 weight portion, Semen Armeniacae Amarum 25 weight portion, Flos Farfarae 20 weight portion, Radix Isatidis 20 weight portion, the Rhizoma Anemarrhenae 16 weight portion, Caulis Perillae 15 weight portion, wild Fructus Momordicae charantiae 25 weight portion, Spora Lygodii 10 weight portion, Herba Cayatiae Japonicae 15 weight portion, PINGDIMU 15 weight portion, Folium Eriobotryae 20 weight portion, Fructus Chebulae 15 weight portion, Herba Hyperici Japonici 10 weight portion, Lasiosphaera Seu Calvatia 20 weight portion, Ramulus et Folium Tamaricis 20 weight portion, Radix Glycyrrhizae 20 weight portion, Herba seu Radix Nothopanacis delavayi 14 weight portion, Folium Vaccinii Fragilis 30 weight portion, Sucus Betulae platyphyllae 4 weight portion, Herba Jussiaeae Repentis 15 weight portion, Rhizoma Pleiones Yunnanensis 25 weight portion, Semen pegani harmalae 4 weight portion and Herba lysimachiae capillipedis 15 weight portion.
Wherein, described pharmaceutical composition further comprises brother king, Rhizoma Marantae bicoloris, water hair flower and Fructus Aristolochiae.
Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material can also be: Herba Houttuyniae 35-40 weight portion, thorn capsule fiber crops 10-20 weight portion, Fructus Schisandrae Chinensis 25-30 weight portion, Herba Diclipterae Chinensis 15-25 weight portion, Ramulus Uncariae Cum Uncis 10-15 weight portion, Herba Artemisiae Annuae 10-14 weight portion, Semen Armeniacae Amarum 20-25 weight portion, Flos Farfarae 10-20 weight portion, Radix Isatidis 15-20 weight portion, Rhizoma Anemarrhenae 10-16 weight portion, Caulis Perillae 15-20 weight portion, wild Fructus Momordicae charantiae 25-30 weight portion, Spora Lygodii 10-20 weight portion, Herba Cayatiae Japonicae 15-20 weight portion, PINGDIMU 15-25 weight portion, Folium Eriobotryae 10-20 weight portion, Fructus Chebulae 15-20 weight portion, Herba Hyperici Japonici 10-20 weight portion, Lasiosphaera Seu Calvatia 15-20 weight portion, Ramulus et Folium Tamaricis 10-20 weight portion, Radix Glycyrrhizae 20-30 weight portion, Herba seu Radix Nothopanacis delavayi 10-14 weight portion, Folium Vaccinii Fragilis 25-30 weight portion, Sucus Betulae platyphyllae 4-10 weight portion, Herba Jussiaeae Repentis 15-20 weight portion, Rhizoma Pleiones Yunnanensis 20-25 weight portion, Semen pegani harmalae 1-4 weight portion, Herba lysimachiae capillipedis 10-15 weight portion, Radix Wikstroemae 2-5 weight portion, Rhizoma Marantae bicoloris 3-5 weight portion, water hair flower 10-20 weight portion and Fructus Aristolochiae 20-30 weight portion.
Wherein, in described pharmaceutical composition, the parts by weight of each raw medicinal material also can be: Herba Houttuyniae 40 weight portion, thorn capsule fiber crops 20 weight portions, Fructus Schisandrae Chinensis 30 weight portion, Herba Diclipterae Chinensis 25 weight portion, Ramulus Uncariae Cum Uncis 15 weight portion, Herba Artemisiae Annuae 14 weight portion, Semen Armeniacae Amarum 25 weight portion, Flos Farfarae 20 weight portion, Radix Isatidis 20 weight portion, the Rhizoma Anemarrhenae 16 weight portion, Caulis Perillae 15 weight portion, wild Fructus Momordicae charantiae 25 weight portion, Spora Lygodii 10 weight portion, Herba Cayatiae Japonicae 15 weight portion, PINGDIMU 15 weight portion, Folium Eriobotryae 20 weight portion, Fructus Chebulae 15 weight portion, Herba Hyperici Japonici 10 weight portion, Lasiosphaera Seu Calvatia 20 weight portion, Ramulus et Folium Tamaricis 20 weight portion, Radix Glycyrrhizae 20 weight portion, Herba seu Radix Nothopanacis delavayi 14 weight portion, Folium Vaccinii Fragilis 30 weight portion, Sucus Betulae platyphyllae 4 weight portion, Herba Jussiaeae Repentis 15 weight portion, Rhizoma Pleiones Yunnanensis 25 weight portion, Semen pegani harmalae 4 weight portion, Herba lysimachiae capillipedis 15 weight portion, Radix Wikstroemae 2 weight portion, Rhizoma Marantae bicoloris 3 weight portion, water hair spends 20 weight portions and Fructus Aristolochiae 20 weight portion.
In order to solve the problems of the technologies described above, present invention also offers a kind of described preparation method being used for the treatment of the pharmaceutical composition of pulmonis Bovis seu Bubali inflammation, wherein, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 40 ~ 60 DEG C subsequently under vacuum 0.05 ~ 0.08Mpa, relative density is the mastic of 1.04 ~ 1.12, spraying dry, the inlet temperature 150 ~ 165 DEG C of spray dryer, leaving air temp 70 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 30 ~ 50 DEG C of dryings, obtains granule.
Wherein, the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 80 ~ 95%, reflux 2 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 2 ~ 4 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.05 ~ 0.2 times, 0.01 ~ 0.12 times of lactose, the starch of 0.01 ~ 0.2 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.02 times of magnesium stearate, granulate, tabletting, makes.
The invention has the beneficial effects as follows: pharmaceutical composition of the present invention, there is heat-clearing and toxic substances removing, while depressed lung-energy dispersing treatment pulmonis Bovis seu Bubali inflammation, the resistance against diseases of cattle can be improved, strengthen its immunity to prevent disease, have in treatment pulmonis Bovis seu Bubali is scorching natural sex, easy inexpensive, multi-functional, have no side effect or very low, free from environmental pollution, the advantageous feature such as Drug resistance is little, and have certain facilitation to the growth of cattle.
Detailed description of the invention
Chinese veterinarian thinks that the traditional Chinese medical science is thought, pneumonia often because of overstrain, liquor-saturated after when the positive QI-insufficiency such as wind, the heresy of the heresy or wind and cold of experiencing wind heat enters caused by inner heat-transformation.
Therefore we select Herba Houttuyniae, thorn capsule fiber crops, Fructus Schisandrae Chinensis, Herba Diclipterae Chinensis, Ramulus Uncariae Cum Uncis, Herba Artemisiae Annuae, Semen Armeniacae Amarum, Flos Farfarae, Radix Isatidis, the Rhizoma Anemarrhenae, Caulis Perillae, wild Fructus Momordicae charantiae, Spora Lygodii, Herba Cayatiae Japonicae, PINGDIMU, Folium Eriobotryae, Fructus Chebulae, Herba Hyperici Japonici, Lasiosphaera Seu Calvatia, Ramulus et Folium Tamaricis, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi, Folium Vaccinii Fragilis, Sucus Betulae platyphyllae, Herba Jussiaeae Repentis, Rhizoma Pleiones Yunnanensis, Semen pegani harmalae, Herba lysimachiae capillipedis.Preferably further comprises brother king, Rhizoma Marantae bicoloris, water hair flower and Fructus Aristolochiae.In all medicines, Herba Houttuyniae, Semen pegani harmalae are as the key medicine for the treatment of lung abscess, are monarch drug.Be equipped with the medicine of wild Fructus Momordicae charantiae, Herba Artemisiae Annuae, Radix Isatidis, the Rhizoma Anemarrhenae, Herba seu Radix Nothopanacis delavayi, Folium Vaccinii Fragilis, Sucus Betulae platyphyllae, Herba Jussiaeae Repentis, Rhizoma Pleiones Yunnanensis, Radix Wikstroemae, Rhizoma Marantae bicoloris, heat-clearing and toxic substances removing; Add again the medicine of the depressed lung-energy dispersing such as Semen Armeniacae Amarum, Caulis Perillae, Flos Farfarae, Folium Eriobotryae, Semen pegani harmalae, Herba lysimachiae capillipedis, water hair flower and Fructus Aristolochiae, assistant has the pneumococcal Chinese herbal medicine of good suppression, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription to sting capsule fiber crops, Fructus Schisandrae Chinensis, Herba Diclipterae Chinensis, Ramulus Uncariae Cum Uncis, Spora Lygodii, Herba Cayatiae Japonicae, PINGDIMU, Fructus Chebulae, Herba Hyperici Japonici, Lasiosphaera Seu Calvatia, Ramulus et Folium Tamaricis etc.
Now each taste medicine is described below:
Herba Houttuyniae: cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The function of inducing diuresis for treating stranguria syndrome.Cure mainly the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.Modern multiplexly control lung abscess, pneumonia, acute and chronic tracheitis, urinary tract infection etc.Modern pharmacology experiment shows, these product have the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, upper respiratory tract infection, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, pulmonary carcinoma, cervical erosion, suppurative arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitisshock, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurative otitis media, mumps, pimple shape urticaria, chronic pharyngitis, anorectal disease, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.
Thorn capsule fiber crops: another name: Radix triumfettae bartramiae, Hemerocallis citrina Baroni louse fiber crops head (" TCM Recipe pharmacy "), bridal veil head mother-in-law, Radix urariae pictae are specially (" Chinese Higher plant illustrated handbook ").Nature and flavor bitter cold, function cures mainly diuresis fossil.Control stranguria caused by urinary stone, cold anemopyretic table disease.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel, Tang etc. " Newly Revised Canon of Materia Medica " carry " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.Ancient medical book Cheng Ta Chi Zhu, profound and, meeting and, it is top grade to list in Sheng Nong's herbal classic the earliest, and herbal function is the power of strengthening by means of tonics, and medical value is high, and general collocation selenium making nourishing the liver sheet and bifendate, Bicyclol etc., have hepatoprotective function.Fructus Schisandrae Chinensis is divided into 2 genus, i.e. Kadsura and Schizandra.These seeds are easily planted, slightly life, and survival rate is high.Have convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, deficient pulse of losing heart, the cards such as interior-heat is quenched one's thirst, palpitation and insomnia.Fructus Schisandrae Chinensis has antiinflammation, to prevent hepar damnification, activates anabolic process to promote the reparation of wounded hepatocytes, and can strengthen the activity of DNA (DNA) synthetic and ornithine decarboxylase, regeneration liver cell.
Canis famililiaris L. grass: " south of the Five Ridges gather medicinal herbs record ": dispel the heat.All steam is contained, liver-fire splendid attire it." Luchuan book on Chinese herbal medicine ": removing heat from blood, heat radiation, removing toxic substances, diuresis.Control furuncle to swell and ache, dysentery, dysuria." Nanning City's medicine will ": removing heat from blood, removing toxic substances, suppressing the hyperactive liver, improving eyesight.Control anthrax, furuncle, the hot hematochezia of intestinal." south of the Five Ridges herbal ": removing heat from the liver, removing heat from blood, promotes the production of body fluid.Dehumidify fiery osteodynia, and macule is generated heat.Herb (Herba Diclipterae Chinensis): sweet, light, cool.Heat-clearing and toxic substances removing, removing heat from blood promotes the production of body fluid, diuresis.For high heat of catching a cold, macule is generated heat, summer-heat excessive thirst, encephalitis b, rheumatic arthritis, laryngopharynx swelling and pain, conjunctival congestion, dysuria; Outer for furuncle and phyma, herpes zoster.
Ramulus Uncariae Cum Uncis: sweet, bitter, be slightly cold; Enter Liver Channel, heart channel." detailed outline ": " the large number of people revolves dizzy, suppressing liver-wind, and except heat in the heart, children's's infantile tic is suffered from abdominal pain, and sends out macule." Tang Materia Medica: " Ramulus Uncariae Cum Uncis goes out Liang Zhou.Leaf is elongated, spinosity between stem, if shape fishhook person." function heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind.Cure mainly infantile convulsion, night cry, intenseness of heat wind symptom, eclamposia, dizziness due to hyperactivity of liver-YANG, liver-fire distending pain in the head.Ramulus Uncariae Cum Uncis decoct, Rhomotoxine mitrinermine, no matter to anesthetized animal or not anesthetized animal, intact animal or hypertension animal, no matter also intravenous injection or gastric infusion all have hypotensive effect.The hemodynamic Effects of Ramulus Uncariae cum Uncis alkali to Conscious Rat shows: LVSP, Vmax, dp/dtmax significantly declines immediately, its fall is respectively one 7.8%, one 15.9% and 1 23.2%, do not maintain 5,10,20 minutes not etc., then level before medicine is returned to gradually, and before being significantly higher than administration when LVSP to 90 minute.
Herba Artemisiae Annuae: bitter, pungent, cold.Return liver, gallbladder meridian, three burnt, kidney channels.Function: clear deficiency-heat thoroughly, removing heat from blood, except steaming, removes and steams, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.This product clearing up internal heat by using drugs of bitter in taste and cold in nature, pungent perfume (or spice) falls apart thoroughly, and the kind the moon that makes divides a latent heat thoroughly to reach outer faling apart, and is fever due to yin deficiency key medicine, has expelling summer-heat in addition, cut cruel merit.Arteether extracts neutral fraction and its rare alcohol extractum to Mus malaria, monkey malaria and people's malaria all in remarkable Antimalarial.Decocting liquid has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, also has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc.Ether extract, rare alcohol extractum and arteannuin to Mus malaria, monkey malaria, people's malaria all in remarkable Antimalarial.Arteannuin also can decreased heart rate, suppresses myocardial contraction, reduces coronary flow.
Semen Armeniacae Amarum: bitter, tepor.Return liver, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.Be good at falling lung qi to relieving asthma, control breathing with cough of excess of the lung.Amygdalate toxicity comes from amygdalin and is hydrolyzed the hydrocyanic acid discharged, and this material can block the respiratory chain of cell, hinders the generation of ATP.Containing amygdaloside in Semen Armeniacae Amarum, amygdaloside can be hydrolyzed by the emulsin of enteric microorganism enzyme or the contained Semen pruni armeniacae of Semen Armeniacae Amarum itself in vivo, produces hydrocyanic acid and the benzaldehyde of trace, has inhibitory action, reach antitussive, antiasthmatic effect to respiratory center.The Semen Armeniacae Amarum bitter in the mouth therapeutic method to keep the adverse QI flowing downwards, and be rich in fatty oil.Fatty oil can improve the lubrication of intestinal contents to mucosa, therefore Semen Armeniacae Amarum has the function of loosening bowel to relieve constipation.The amygdalate water extract of defat to caused by acetic acid mouse writhing reaction and cotton balls caused by rat granulomatous inflammation be formed with inhibitory action.
Flos Farfarae: acrid in the mouth, warm in nature; Return lung meridian." Japan hanako materia medica ": " relieving restlessness, benefit labor is bad, stopping coughing and removing phlegm, and pulmonary fistula is spitted blood, and palpitation with fear of having a guilty conscience, washes liver improving eyesight and apoplexy for profit cardiopulmonary, beneficial the five internal organs." " book on Chinese herbal medicine take advantage of refined half brave ": " leisurely Flos Farfarae is with controlling cough with dyspnea, kindly breathing heavily, and sore throat, because kidney is bitter dry and cold physique drink is cold, being attacked by pathogenic dampness in autumn person is begun suitable.Or burning hot punishment gold, or withering lung lobes with stuffy lung-QI, probably benefit disappears to sparkle and injures." preventing phlegm from forming and stopping coughing.There is the antitussive therapeutic method to keep the adverse QI flowing downwards, the function that lung moistening is eliminated the phlegm.For cough, asthma, consumptive lung disease, coughs the diseases such as blood of spitting.Flower is containing sterols, globulariacitrin, hyperin, triterpenoid saponin, tannin, wax, volatile oil and taraxanthins such as faradiols.Leaf is containing bitterness glycoside 2.63%, gallic acid, gum elastic sample material, dextrin, mucus, inulin, plant sterol, stearic acid and tripalmitin, tartaric acid, malic acid, Nulomoline, choline, Hydrocarbon and Saponin.
Radix Isatidis: nature and flavor, bitter cold.Heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly maculae caused by violent heat pathogen, high heat headache, major part pestilence, crimson tongue is purple dark, scarlet fever, erysipelas, mumps, sore throat, and skin ulcer is swollen, carbuncle, chickenpox, measles, hepatitis, influenza, epidemic encephalitis, encephalitis b, pneumonia, and coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, 1. for epidemic febrile disease, evil in edema caused by disorder of QI, the edema caused by disorder of QI excess-heat syndrome of high heat, excessive thirst, has the effect of pathogenic fire purging relieving restlessness, has collaborative effect with Gypsum Fibrosum, Folium Bambusae compatibility.2. be used for the treatment of cough due to lung-heat or deficiency of YIN cough caused by dryness, have and let out lung-fire clearly, the effect of nourishing YIN and moistening the lung.Normal and Bulbus Fritillariae Uninbracteatae is same in order to strengthen the merit of clearing away lung-heat and moistening for dryness, as female loose in " collection of prescriptions with notes " two.3., for hyperactivity of fire caused by deficiency of YIN, osteopyrexia and fever, night sweat person, has the effect of nourishing YIN to lower pathogenic fire, and normal and Cortex Phellodendri mutual reinforcement between is for use.4. can let out clearly the fire of lung stomach, again can the moon of nourishing the lung and kidney, therefore the deficiency of YIN should be used for quench one's thirst.The Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.
Caulis Perillae: function cures mainly: regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch is vomitted, frequent fetal movement." not Lu ": " the main therapeutic method to keep the adverse QI flowing downwards, except excessive cold invading middle-JIAO(the spleen and stomach)." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " diaphoresis, separate anemogenous headache, expectorant, surely shouts and breathes heavily." Folium Perillae pungent temperature row is loose, leaf is light as lung, energy dispersing wind-cold, lung qi dispersing cough-relieving; Stalk as taste, be good at circulation of qi promoting with in, regulate the flow of vital energy antiabortive.Therefore commonly used by cough due to wind and cold, stagnation of QI in spleen and stomach, in addition, separate again the poison of fish Eriocheir sinensis.
Wild Fructus Momordicae charantiae: abnormal smells from the patient is bitter, nontoxic, cold in nature, enters the heart, liver, spleen, lung meridian.There is clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separate that labor clears away heart-fire, effect of QI invigorating tonifying YANG.There is cool, thirst-quenching, heat-clearing and toxic substances removing, the improving eyesight that clears away heart-fire, QI invigorating recover from fatigue, the effect of kidney tonifying diuresis.Containing multivitamin, mineral in Fructus Momordicae charantiae, the magistery containing fat eliminating, fat-reducing, can accelerate toxin expelling.Find according to the study, it also has good blood sugar lowering, antiviral and anti-cancer efficacy.Cure mainly the disease such as heatstroke, summer-heat excessive thirst, summer boil, miliaria is too much, dysentery, skin ulcer are swollen, conjunctivitis, conjunctival congestion and swelling pain, carbuncle erysipelas, burn and scald, oliguria.In addition, the Vitamin C content of Fructus Momordicae charantiae is very high, has the effects such as prevention vitamin C deficiency, Cell protection film, atherosclerosis, raising physical stress ability, cardioprotection.Promote diet, anti-inflammatory antipyretic: the Charantin in Fructus Momordicae charantiae and bitter principle energy appetite stimulator, spleen benefiting and stimulating the appetite; Contained alkaloids substance quinine, have diuresis to invigorate blood circulation, anti-inflammatory antipyretic, the improving eyesight that clears away heart-fire effect.Cancer-resisting: bitter melon protein matter composition and vitamin C can improve the immunologic function of body, makes immunocyte have to kill the effect of cancerous cell; Succus Momordicae charantiae contains certain protein ingredient, can strengthen the huge ability of biting, clinically to lymphosarcoma and leukemia effective; The trypsin inhibitor extracted from bitter melon seed, can protease out secreted by anticancer, stops malignant growth. and bitter principle contained in Fructus Momordicae charantiae can suppress malignant tumor secretory protein, the growth of control cancerous cell and diffusion.Have experiment to find abroad, Fructus Momordicae charantiae can make bottom the tongue of people, larynx, oral cavity, the Growth of Cells of nasopharynx part cancer is suppressed.Protein in Fructus Momordicae charantiae and the anticancer mechanism of Charantin, mainly they can activate the defense function of vivo immuning system, strengthen the activity of immunocyte, the propagation of T suppression cell or killed.Japanese Scientists is thought, bitter melon protein can improve the immunologic function of body, can eliminate cancerous cell by Promote immunity cell.
Spora Lygodii: sweet, light, cold in nature; Return small intestine meridian, urinary bladder channel.Nontoxic.Compendium of Material Medica: control damp and hot generalized edema with distention of the chest and abdomen, urine pyretic stranguria, stranguria marked by chyluria, stranguria with blood, stranguria caused by urinary stone, pain in the penis, antipyretic poison.Have tonneau small intestinal, cold and heat of curing the wound are mad, control damp and hot toxic swelling, urine pyretic stranguria stranguria marked by chyluria stranguria with blood, stranguria caused by urinary stone dysmenorrhoea, antipyretic poison ".Bones and muscles pain heat-clearing and toxic substances removing is controlled with it in Sichuan again, relieving stranguria by diuresis.Control urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.
Herba Cayatiae Japonicae: sour, bitter, cold, nontoxic.After one's own heart, liver, stomach warp.Tang Materia Medica: " main air is scorchingly hot swollen, and You Dan, snakebite, smashes and apply and drink juice." " vegetation is side just ": " heat-clearing and toxic substances removing, be coated with sore, disappear tuberculosis, and nine fictitious gas infectionss, tonification is deficient." heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, diuresis.For laryngopharynx swelling and pain, furuncle and phyma, carbuncle, furuncle, dysentery, hematuria, nebulousurine, traumatic injury, venom.Herba Cayatiae Japonicae injection 1%, 10% concentration, proves all have inhibitory action to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, card ground coccus, streptococcus pneumoniae, hemophilus influenza with Plating.Herba Cayatiae Japonicae injection 1:10,1:100 dilution mixes with virus injects chick embryo allantois intracavity, and the anti--77-56-E2 in popularity cold virus A3/ Shanghai and capital section 68-1 strain have obvious inhibitory action.
PINGDIMU: property is put down, acrid in the mouth, micro-hardship; Return lung, Liver Channel.Cure mainly new chronic cough to cough, sputum mixed with blood, jaundice, edema, stranguria, leucorrhea, amenorrhea dysmenorrhea, rheumatic arthralgia, traumatic injury, painful and swollen testis.PINGDIMU has antitussive, eliminate the phlegm, the effect such as to relieving asthma, and its decoct and Bergeninum have obvious antitussive action to the mouse cough that the cough caused by electricity irritation cat superior laryngeal nerve and ammonia spraying cause.PINGDIMU water decoction has inhibitory action to staphylococcus aureus, streptococcus pneumoniae, and has certain inhibitory action to the influenza virus being inoculated in Embryo Gallus domesticus.Rhizoma Seu Herba Bergeniae for oral administration have the effect of certain prevention and therapy chronic tracheitis, and show as goblet cell and reduce, cell infiltration, the pathologic such as emphysema and the pulmonary collapse changes degree and alleviates.
Folium Eriobotryae: bitter in the mouth, cold nature, returns lung, stomach warp, has clearing away lung-heat to relieve cough, effect of stopping nausea and vomiting by lowering the adverse flow of QI, this product bitter cold, energy clearing away lung-heat, falls lung qi with cough-relieving, be usually used in treatment cough due to lung-heat, abundant expectoration yellow skin, can fall gastric qi and preventing or arresting vomiting is inverse, for the vomiting that gastric heat causes, treatment xerostomia is quenched one's thirst, lung-wind syndrome acne vulgaris, acne.
Fructus Chebulae: sour in the mouth, puckery, property is put down, and returns lung, large intestine channel, " property of medicine opinion ": " tonneau body fluid, main broken chest and diaphragm stagnation of QI, sealing road, black moustache is sent out." " Haiyao Bencao, Oversea Materia Medica ": " main five types of dysphagia is tied, the empty pain of trusted subordinate, red white all dysentery and vomiting cough, and should make skin, and its master coughs.Meat is processed and is controlled the puckery pain of eye." there is relieving diarrhea with astringents, astringing lung-QI and relieving cough, effect of pathogenic fire reducing sore-throat relieving, for chronic diarrhea chronic dysentery, proctoptosis of having blood in stool, cough and asthma due to lung deficiency, chronic cough is more than, the cards such as pharyngalgia hoarseness.Fructus Chebulae is more containing tannin, therefore has similar gallic convergence, anti-diarrhea effect. but except tannin, still contain diarrhea inducing composition because of it, thus similar to Radix Et Rhizoma Rhei, first diarrhea inducing is then restrained.Fructus Chebulae's water decoction (100%) all has inhibitory action to various dysentery bacterium, comparatively strong to the effect of bacillus pyocyaneus, diphtheria corynebacterium, also there is inhibitory action to staphylococcus aureus, escherichia coli, streptococcus pneumoniae, Hemolytic streptococcus, Bacillus proteus, bacillus typhi murium.Terchebin in Fructus Chebulae has the spasmolysis of papaverine sample to smooth muscle.
Herba Hyperici Japonici: Herba Hyperici Japonici: bitter in the mouth, flat; Return liver, gallbladder meridian." the SHENGCAO property of medicine is standby to be wanted ": " control wine disease, subside a swelling swollen, apply large malignant boil, reason chancre swells." " south of the Five Ridges gather medicinal herbs record ": " remove the yellow fire-toxin of nitre, apply shrimp pincers skin ulcer, reason traumatic injury, snakebite." dampness removing jaundice eliminating, heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Control infectious hepatitis, dysentery, infantile convulsion, infantile malnutrition, throat moth, acute appendicitis, furuncle and phyma, venom.This product hardship is cool, enters liver and gall warp, clear dampness-heat in the liver and gallbladder can have function of gallbladder promoting jaundice, alone heavy dose of decoction or with the compatibility such as Herba Lysimachiae, Herba Artemisiae Scopariae, Rhizoma Polygoni Cuspidati.All therapeutical effect is had to acute icterohepatitis, chronic hepatitis.This product promoting blood circulation and detumescence, for traumatic injury pain caused by ecchymoma, alone or join the decoctions such as Rhizoma Drynariae, Olibanum, Myrrha; Also can mash external application by fresh goods simultaneously.Antibacterial and bactericidal action is in various degree had in vitro to bacillus tuberculosis bovis, streptococcus pneumoniae, staphylococcus aureus, hog cholera bacillus and dysentery bacterium.
Lasiosphaera Seu Calvatia: pungent, flat, nontoxic.Main be used as local hemostatic, doublely control throat pain, aphonia etc.Traumatic hemorrhage, epistaxis, postextraction hemorrhage: Lasiosphaera Seu Calvatia tears epithelium off, gets inner sponge floss sample thing compressing bleeding part or fills in nostril, filling gingiva place, have good hemostatic function.
Ramulus et Folium Tamaricis: sweet in the mouth, pungent, property are put down; Return lung meridian, stomach warp, heart channel.Essentials of Matea Medica: " control acute diseases such as cholera and sunstroke rash not go out, breathe heavily vexed unrest of coughing." function dispelling wind, induce sweat, rash, removing toxic substances.Cure mainly anemopyretic cold, measles goes out saturating from the beginning of, rash, rheumatic arthralgia, skin pruritus.Control measles thoroughly difficult, rubella itching over the body, flu, cough with asthma, rheumatic ostalgia.Ramulus et Folium Tamaricis decoct injects 5g/kg to mouse peritoneal, has obvious antitussive action (ammonia spraying draws the method for coughing), but without phlegm-dispelling functions (the phenol red method of mice).In vitro tests, Ramulus et Folium Tamaricis decoct all has inhibitory action to streptococcus pneumoniae, alpha streptococcus, Staphylococcus albus and hemophilus influenza.
Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances "." property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.
Herba seu Radix Nothopanacis delavayi: Araliaceae vacation ginseng platymiscium Herba seu Radix Nothopanacis delavayi Nothopanax delavayi (Franch.) Harms ex Diels, is used as medicine with Herb.The whole year can adopt, using fresh herb or dry.Sweet, the micro-hardship of nature and flavor, cool.Function cures mainly heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation.For acute pharyngitis, acute conjunctivitis, dyspepsia, lumbago, skelalgia of rheumatism; Fracture is controlled in external, traumatic injury.
Folium Vaccinii Fragilis: be the root of ericad Corvus macrorhuchus fruit (Mao Yewu meal).Nature and flavor " Guangdong Chinese medicine ": " sweet, cold." 1. function cures mainly " Guangdong Chinese medicine ": " is heat and toxic materials clearing away medicine.Control carbuncle skin ulcer furunculosis, numb varioliform exanthema poison, chancre dysentery, skin heat in blood.It is poisoning that " 2. " south mainly contains poisonous plant ": " separates Flos Daturae, Ramulus et Folium Bauhiniae Faberi, jequirity, Radix Sophorae Flavescentis, white snowflake, large tea medicine etc."
Sucus Betulae platyphyllae: be the juice flowed out in Betulaceae North China Betula platyphylla Suk. or Betula platyphylla Suk. trunk.Between May, bark is scratched, contain and get juice, using fresh herb.1. function cures mainly " Jilin Chinese herbal medicine ": " cough-relieving.Control phlegm dyspnea cough." 2. " Chinese herbal medicine handbook is commonly used in Heilungkiang ": " controls vitamin C deficiency, nephropathy, gout.There is antipyretic and antidote functions."
Herba Jussiaeae Repentis: nature and flavor are " the SHENGCAO property of medicine is standby to be wanted " 1.: " lightly seasoned, cold in nature." 2. " Fujian traditional herbal medicine ": " is sweet, cold, nontoxic." function cures mainly heat clearing away, diuresis, detumescence, removing toxic substances.Control cough caused by dryness-heat, alcoholic jaundice, gonorrhea, measles, erysipelas, carbuncle furuncle.1. " the SHENGCAO property of medicine is standby to be wanted ": " reason wine is sick, applies carbuncle on the back, treating snakebite, top dog bite, and diuresis smashes juice drink." 2. " Tian Bao book on Chinese herbal medicine ": " dampness removing heat, row water channel, controls bones and muscles pain." 3. " Fujian traditional herbal medicine ": " diuresis is antipyretic.Reason alcoholic jaundice, treating snakebite." 4. " Luchuan book on Chinese herbal medicine ": " heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control epidemic blisters, pruritus." 5. " Traditional Chinese Medicine in Sichuan will ": " controls various sore and gonorrhea."
Rhizoma Pleiones Yunnanensis: nature and flavor " Yunnan Chinese herbal medicine ": " bitter, flat." function cures mainly tonifying the lung, relieving cough and resolving phlegm, hemostasia and promoting granulation.Control silicosis, pulmonary tuberculosis, pertussis, tracheitis, digestive tract hemorrhage, carbuncle, traumatic hemorrhage.1. " Yunnan Chinese herbal medicine ": " relieving cough and resolving phlegm, tonifying the lung granulation promoting." 2. " catalogue planted by Guizhou medicine ": " heat-clearing and toxic substances removing, cough-relieving." 3. " choosing of Yunnan Chinese herbal medicine ": " lung moistening, hemostasis.Control silicosis, pulmonary tuberculosis, tracheitis, digestive tract hemorrhage, traumatic hemorrhage, furuncle and phyma, traumatic injury."
Semen pegani harmalae: nature and flavor " the sweet peaceful blue or green Chinese herbal medicine choosing in Shan ": " bitter, temperature." function cures mainly and controls cough, dysuria, numb limbs and tense tendons, joint aches.1. " Chinese Herbal Medicine in Xinjiang handbook ": " lung qi dispersing cough-relieving.Control cough and asthma, dysuria." 2. " the sweet peaceful blue or green Chinese herbal medicine choosing in Shan ": " antitussive and antiasthmatic, wind-damp dispelling."
Herba lysimachiae capillipedis: ecological environment: sylvan life and the small stream limit, mountain valley of being born in height above sea level 1200-2300m.Resource distribution: be distributed in the ground such as Yunnan, Taiwan.Nature and flavor are pungent; Sweet; Property is put down.Return through liver; Lung meridian.Function cures mainly dispelling wind and ventilating the lung; Relieving cough and asthma.Main flu; Cough; Asthma.
Radix Wikstroemae: nature and flavor are bitter, micro-pungent, cold.Function cures mainly heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, and stimulate the menstrual flow diuretic.Root, root double-layer fur (endothelium) cure mainly: tonsillitis, parotitis, lymphadenitis, bronchitis, asthma, pneumonia, rheumatic arthritis, traumatic injury, leprosy, amenorrhea, edema.Leaf cures mainly: acute mastitis is controlled in external, cellulitis.
Rhizoma Marantae bicoloris: there is cultivation on the ground such as distribution China Guangdong, Guangxi.Originate in Brazil.Nature and flavor bitter in the mouth; Pungent; Cold in nature.Return through heart channel.Function cures mainly heat-clearing and toxic substances removing; Mass dissipating and swelling eliminating.Main carbuncle; Skin infection; Innominate toxic swelling; Traumatic injury; Swelling and pain due to blood stasis.
Water hair flower: ecological environment: be born in ditch, the pool, lakeside and small stream limit grassplot.Resource distribution: except Xinjiang, Tibet, be widely distributed in all parts of the country.Nature and flavor bitter in the mouth; Pungent; Cool in nature.Function cures mainly clearing away heat and expelling pathogen in the exterior; Lung qi dispersing cough-relieving.Main cold, fever; Cough.
Fructus Aristolochiae: nature and flavor are bitter, are slightly cold.Gui Jing returns lung, large intestine channel.Function cures mainly lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, and bowel relieving disappears hemorrhoid.For dyspnea and cough due to lung-heat, sputum mixed with blood, the hot hemorrhoidal bleeding of intestinal, swelling and pain of hemorrhoid.
Described Chinese medicine composition is only made up of above-mentioned raw materials medical material.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
Herba Houttuyniae 40 parts, thorn capsule fiber crops 20 parts, Fructus Schisandrae Chinensis 30 parts, Herba Diclipterae Chinensis 25 parts, Ramulus Uncariae Cum Uncis 15 parts, Herba Artemisiae Annuae 14 parts, 25 parts, Semen Armeniacae Amarum, Flos Farfarae 20 parts, Radix Isatidis 20 parts, the Rhizoma Anemarrhenae 16 parts, Caulis Perillae 15 parts, wild Fructus Momordicae charantiae 25 parts, Spora Lygodii 10 parts, Herba Cayatiae Japonicae 15 parts, PINGDIMU 15 parts, Folium Eriobotryae 20 parts, Fructus Chebulae 15 parts, Herba Hyperici Japonici 10 parts, Lasiosphaera Seu Calvatia 20 parts, Ramulus et Folium Tamaricis 20 parts, 20 parts, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi 14 parts, Folium Vaccinii Fragilis 30 parts, Sucus Betulae platyphyllae 4 parts, Herba Jussiaeae Repentis 15 parts, Rhizoma Pleiones Yunnanensis 25 parts, Semen pegani harmalae 4 parts and Herba lysimachiae capillipedis 15 parts.
Its preparation process is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.12, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 times and 0.1 times in the dried cream powder obtained, makes granule, in 30 DEG C of dryings, obtains granule.
Embodiment 2 tablet
Herba Houttuyniae 40 parts, thorn capsule fiber crops 20 parts, Fructus Schisandrae Chinensis 30 parts, Herba Diclipterae Chinensis 25 parts, Ramulus Uncariae Cum Uncis 15 parts, Herba Artemisiae Annuae 14 parts, 25 parts, Semen Armeniacae Amarum, Flos Farfarae 20 parts, Radix Isatidis 20 parts, the Rhizoma Anemarrhenae 16 parts, Caulis Perillae 15 parts, wild Fructus Momordicae charantiae 25 parts, Spora Lygodii 10 parts, Herba Cayatiae Japonicae 15 parts, PINGDIMU 15 parts, Folium Eriobotryae 20 parts, Fructus Chebulae 15 parts, Herba Hyperici Japonici 10 parts, Lasiosphaera Seu Calvatia 20 parts, Ramulus et Folium Tamaricis 20 parts, 20 parts, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi 14 parts, Folium Vaccinii Fragilis 30 parts, Sucus Betulae platyphyllae 4 parts, Herba Jussiaeae Repentis 15 parts, Rhizoma Pleiones Yunnanensis 25 parts, Semen pegani harmalae 4 parts, Herba lysimachiae capillipedis 15 parts, Radix Wikstroemae 2 parts, Rhizoma Marantae bicoloris 3 parts, water hair spends 20 parts and Fructus Aristolochiae 20 parts.
Its preparation process is:
The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 300 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.05 times, 0.01 times of lactose, the starch of 0.01 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.005 times of magnesium stearate, granulate, tabletting, makes.
Embodiment 3 decoction
Herba Houttuyniae 35 parts, thorn capsule fiber crops 20 parts, Fructus Schisandrae Chinensis 25 parts, Herba Diclipterae Chinensis 25 parts, Ramulus Uncariae Cum Uncis 10 parts, Herba Artemisiae Annuae 14 parts, 20 parts, Semen Armeniacae Amarum, Flos Farfarae 20 parts, Radix Isatidis 15 parts, the Rhizoma Anemarrhenae 16 parts, Caulis Perillae 15 parts, wild Fructus Momordicae charantiae 30 parts, Spora Lygodii 10 parts, Herba Cayatiae Japonicae 20 parts, PINGDIMU 15 parts, Folium Eriobotryae 20 parts, Fructus Chebulae 15 parts, Herba Hyperici Japonici 20 parts, Lasiosphaera Seu Calvatia 15 parts, Ramulus et Folium Tamaricis 20 parts, 20 parts, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi 14 parts, Folium Vaccinii Fragilis 25 parts, Sucus Betulae platyphyllae 10 parts, Herba Jussiaeae Repentis 15 parts, Rhizoma Pleiones Yunnanensis 25 parts, Semen pegani harmalae 4 parts, Herba lysimachiae capillipedis 15 parts, Radix Wikstroemae 5 parts, Rhizoma Marantae bicoloris 3 parts, water hair spends 20 parts and Fructus Aristolochiae 20 parts.
Its preparation process is:
Purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 5cm, soak 10 hours; Be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use; Residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 10 hours; Be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
The toxicity test of pharmaceutical composition
1. trial drug:
Medicine one: by described raw medicinal material Herba Houttuyniae 35 parts, thorn capsule fiber crops 10 parts, Fructus Schisandrae Chinensis 25 parts, Herba Diclipterae Chinensis 15 parts, Ramulus Uncariae Cum Uncis 10 parts, Herba Artemisiae Annuae 10 parts, 20 parts, Semen Armeniacae Amarum, Flos Farfarae 10 parts, Radix Isatidis 15 parts, the Rhizoma Anemarrhenae 10 parts, Caulis Perillae 15 parts, wild Fructus Momordicae charantiae 25 parts, Spora Lygodii 10 parts, Herba Cayatiae Japonicae 15 parts, PINGDIMU 15 parts, Folium Eriobotryae 10 parts, Fructus Chebulae 15 parts, Herba Hyperici Japonici 10 parts, Lasiosphaera Seu Calvatia 15 parts, Ramulus et Folium Tamaricis 10 parts, 20 parts, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi 10 parts, Folium Vaccinii Fragilis 25 parts, Sucus Betulae platyphyllae 4 parts, Herba Jussiaeae Repentis 15 parts, Rhizoma Pleiones Yunnanensis 20 parts, Semen pegani harmalae 4 parts, purple casserole is put in Herba lysimachiae capillipedis 10 parts of mixing, add clear water, to clear water dipped medical material upper surface 5cm, soak 10 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use, residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 10 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Medicine two: by described raw medicinal material Herba Houttuyniae 40 parts, thorn capsule fiber crops 20 parts, Fructus Schisandrae Chinensis 30 parts, Herba Diclipterae Chinensis 25 parts, Ramulus Uncariae Cum Uncis 15 parts, Herba Artemisiae Annuae 14 parts, 25 parts, Semen Armeniacae Amarum, Flos Farfarae 20 parts, Radix Isatidis 20 parts, the Rhizoma Anemarrhenae 16 parts, Caulis Perillae 20 parts, wild Fructus Momordicae charantiae 30 parts, Spora Lygodii 20 parts, Herba Cayatiae Japonicae 20 parts, PINGDIMU 25 parts, Folium Eriobotryae 20 parts, Fructus Chebulae 20 parts, Herba Hyperici Japonici 20 parts, Lasiosphaera Seu Calvatia 20 parts, Ramulus et Folium Tamaricis 20 parts, 30 parts, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi 14 parts, Folium Vaccinii Fragilis 30 parts, Sucus Betulae platyphyllae 10 parts, Herba Jussiaeae Repentis 20 parts, Rhizoma Pleiones Yunnanensis 25 parts, Semen pegani harmalae 4 parts, Herba lysimachiae capillipedis 15 parts, Radix Wikstroemae 5 parts, Rhizoma Marantae bicoloris 5 parts, water hair spends 20 parts to put into purple casserole with Fructus Aristolochiae 30 parts of mixing, add clear water, to clear water dipped medical material upper surface 5cm, soak 10 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use, residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 10 hours, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
2. test method:
Method one: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Trial drug one is dissolved in water, (concentration is 6g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 30g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore pharmaceutical composition acute toxicity of the present invention is low, clinical drug safety.
Method two: trial drug two pairs of mices are pressed 7g, 14g and 35g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical composition of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical composition of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Contrast test
Experimental animal
1 ~ June in 2013 is investigated 300 of cattle farm, Harbin City cattle, this cattle generation pneumonia have 150, sickness rate reaches 50%, dead calf 30, and mortality rate is 10%, causes very large economic loss to this.The tested sick cattle that 100 body weight are more or less the same comes from the cattle of the natural occurrence of this cattle farm, is divided into 4 groups at random, embodiment group, embodiment 2 groups, embodiment 3 groups and matched group, often organizes 25.
Test method
Embodiment 1 group: this group 25 ill cattle, adopts the granule of embodiment 1 to treat.Granule is mixed in daily feedstuff according to the ratio of 3:100, normally feeds, carry out 3 days.
Embodiment 2 groups: this group 25 ill cattle, adopts the tablet of embodiment 2 to treat.Tablet is mixed in daily feedstuff according to the ratio of 3:100, normally feeds, carry out 3 days.
Embodiment 3 groups: this group 25 ill cattle, adopts the decoction of embodiment 3 to treat.Decoction is mixed in daily feedstuff according to the ratio of 3:100, normally feeds, carry out 3 days.
Matched group: this group 25 ill cattle, adopts enrofloxacin injection to treat.Intramuscular injection 0. 25% enrofloxacin injection, every each 2ml × 3, and daily feedstuff of simultaneously normally feeding, carry out 3 days.
Recovery from illness criterion
Ill cattle external symptom disappears, and body temperature, pulse and breathing recover normal, auscultation of lung respiratory murmur without exception.
Therapeutic outcome
The situation of record recovery from illness before and after treatment, counts table 1, and the body weight change situation before and after record treatment counts table 2.
Recovery from illness situation before and after the treatment that table 1 is respectively organized
Can find out see table 1, the recovery from illness number of the treatment of embodiment 1 group, embodiment 2 groups and embodiment 3 groups and cure rate are all higher than recovery from illness number and the cure rate of matched group, can learn, pharmaceutical composition of the present invention, in treatment pulmonis Bovis seu Bubali inflammation, therapeutic effect is good, determined curative effect, well improves the state of an illness.
Table 2 is the balanced growth body weight contrast of the cattle of each group
Can find out see table 2, while the treatment pulmonis Bovis seu Bubali inflammation of embodiment 1 group, embodiment 2 groups and embodiment 3 groups, growth rate all faster than matched group, will maintain the normal growth of cattle.
In sum, pharmaceutical composition of the present invention, in treatment pulmonis Bovis seu Bubali inflammation, therapeutic effect is good, determined curative effect, and ensure that the normal growth of cattle.
Citing: there is cattle 200 in vaccary, Shenyang City, in August, 2013,80 symptoms occurring pulmonis Bovis seu Bubali inflammation.Select 80 ill cattle to isolate for treatment, select the medicinal composition tablets of embodiment 2, be mixed in conventional feed according to the ratio of 3:100 and normally feed, treat 3, recovery from illness be 76, cure rate 95%.Body weight increases 5.1kg at treatments period.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. one kind is used for the treatment of the pharmaceutical composition of pulmonis Bovis seu Bubali inflammation, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Herba Houttuyniae, thorn capsule fiber crops, Fructus Schisandrae Chinensis, Herba Diclipterae Chinensis, Ramulus Uncariae Cum Uncis, Herba Artemisiae Annuae, Semen Armeniacae Amarum, Flos Farfarae, Radix Isatidis, the Rhizoma Anemarrhenae, Caulis Perillae, wild Fructus Momordicae charantiae, Spora Lygodii, Herba Cayatiae Japonicae, PINGDIMU, Folium Eriobotryae, Fructus Chebulae, Herba Hyperici Japonici, Lasiosphaera Seu Calvatia, Ramulus et Folium Tamaricis, Radix Glycyrrhizae, Herba seu Radix Nothopanacis delavayi, Folium Vaccinii Fragilis, Sucus Betulae platyphyllae, Herba Jussiaeae Repentis, Rhizoma Pleiones Yunnanensis, Semen pegani harmalae and Herba lysimachiae capillipedis.
2. the pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation according to claim 1, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Houttuyniae 35-40 weight portion, thorn capsule fiber crops 10-20 weight portion, Fructus Schisandrae Chinensis 25-30 weight portion, Herba Diclipterae Chinensis 15-25 weight portion, Ramulus Uncariae Cum Uncis 10-15 weight portion, Herba Artemisiae Annuae 10-14 weight portion, Semen Armeniacae Amarum 20-25 weight portion, Flos Farfarae 10-20 weight portion, Radix Isatidis 15-20 weight portion, Rhizoma Anemarrhenae 10-16 weight portion, Caulis Perillae 15-20 weight portion, wild Fructus Momordicae charantiae 25-30 weight portion, Spora Lygodii 10-20 weight portion, Herba Cayatiae Japonicae 15-20 weight portion, PINGDIMU 15-25 weight portion, Folium Eriobotryae 10-20 weight portion, Fructus Chebulae 15-20 weight portion, Herba Hyperici Japonici 10-20 weight portion, Lasiosphaera Seu Calvatia 15-20 weight portion, Ramulus et Folium Tamaricis 10-20 weight portion, Radix Glycyrrhizae 20-30 weight portion, Herba seu Radix Nothopanacis delavayi 10-14 weight portion, Folium Vaccinii Fragilis 25-30 weight portion, Sucus Betulae platyphyllae 4-10 weight portion, Herba Jussiaeae Repentis 15-20 weight portion, Rhizoma Pleiones Yunnanensis 20-25 weight portion, Semen pegani harmalae 1-4 weight portion and Herba lysimachiae capillipedis 10-15 weight portion.
3. the pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Houttuyniae 40 weight portion, thorn capsule fiber crops 20 weight portions, Fructus Schisandrae Chinensis 30 weight portion, Herba Diclipterae Chinensis 25 weight portion, Ramulus Uncariae Cum Uncis 15 weight portion, Herba Artemisiae Annuae 14 weight portion, Semen Armeniacae Amarum 25 weight portion, Flos Farfarae 20 weight portion, Radix Isatidis 20 weight portion, the Rhizoma Anemarrhenae 16 weight portion, Caulis Perillae 15 weight portion, wild Fructus Momordicae charantiae 25 weight portion, Spora Lygodii 10 weight portion, Herba Cayatiae Japonicae 15 weight portion, PINGDIMU 15 weight portion, Folium Eriobotryae 20 weight portion, Fructus Chebulae 15 weight portion, Herba Hyperici Japonici 10 weight portion, Lasiosphaera Seu Calvatia 20 weight portion, Ramulus et Folium Tamaricis 20 weight portion, Radix Glycyrrhizae 20 weight portion, Herba seu Radix Nothopanacis delavayi 14 weight portion, Folium Vaccinii Fragilis 30 weight portion, Sucus Betulae platyphyllae 4 weight portion, Herba Jussiaeae Repentis 15 weight portion, Rhizoma Pleiones Yunnanensis 25 weight portion, Semen pegani harmalae 4 weight portion and Herba lysimachiae capillipedis 15 weight portion.
4. the pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation according to any one of claim 1-3, is characterized in that, described pharmaceutical composition further comprises brother king, Rhizoma Marantae bicoloris, water hair flower and Fructus Aristolochiae.
5. the pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Houttuyniae 35-40 weight portion, thorn capsule fiber crops 10-20 weight portion, Fructus Schisandrae Chinensis 25-30 weight portion, Herba Diclipterae Chinensis 15-25 weight portion, Ramulus Uncariae Cum Uncis 10-15 weight portion, Herba Artemisiae Annuae 10-14 weight portion, Semen Armeniacae Amarum 20-25 weight portion, Flos Farfarae 10-20 weight portion, Radix Isatidis 15-20 weight portion, Rhizoma Anemarrhenae 10-16 weight portion, Caulis Perillae 15-20 weight portion, wild Fructus Momordicae charantiae 25-30 weight portion, Spora Lygodii 10-20 weight portion, Herba Cayatiae Japonicae 15-20 weight portion, PINGDIMU 15-25 weight portion, Folium Eriobotryae 10-20 weight portion, Fructus Chebulae 15-20 weight portion, Herba Hyperici Japonici 10-20 weight portion, Lasiosphaera Seu Calvatia 15-20 weight portion, Ramulus et Folium Tamaricis 10-20 weight portion, Radix Glycyrrhizae 20-30 weight portion, Herba seu Radix Nothopanacis delavayi 10-14 weight portion, Folium Vaccinii Fragilis 25-30 weight portion, Sucus Betulae platyphyllae 4-10 weight portion, Herba Jussiaeae Repentis 15-20 weight portion, Rhizoma Pleiones Yunnanensis 20-25 weight portion, Semen pegani harmalae 1-4 weight portion, Herba lysimachiae capillipedis 10-15 weight portion, Radix Wikstroemae 2-5 weight portion, Rhizoma Marantae bicoloris 3-5 weight portion, water hair flower 10-20 weight portion and Fructus Aristolochiae 20-30 weight portion.
6. the pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation according to any one of claim 1-5, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba Houttuyniae 40 weight portion, thorn capsule fiber crops 20 weight portions, Fructus Schisandrae Chinensis 30 weight portion, Herba Diclipterae Chinensis 25 weight portion, Ramulus Uncariae Cum Uncis 15 weight portion, Herba Artemisiae Annuae 14 weight portion, Semen Armeniacae Amarum 25 weight portion, Flos Farfarae 20 weight portion, Radix Isatidis 20 weight portion, the Rhizoma Anemarrhenae 16 weight portion, Caulis Perillae 15 weight portion, wild Fructus Momordicae charantiae 25 weight portion, Spora Lygodii 10 weight portion, Herba Cayatiae Japonicae 15 weight portion, PINGDIMU 15 weight portion, Folium Eriobotryae 20 weight portion, Fructus Chebulae 15 weight portion, Herba Hyperici Japonici 10 weight portion, Lasiosphaera Seu Calvatia 20 weight portion, Ramulus et Folium Tamaricis 20 weight portion, Radix Glycyrrhizae 20 weight portion, Herba seu Radix Nothopanacis delavayi 14 weight portion, Folium Vaccinii Fragilis 30 weight portion, Sucus Betulae platyphyllae 4 weight portion, Herba Jussiaeae Repentis 15 weight portion, Rhizoma Pleiones Yunnanensis 25 weight portion, Semen pegani harmalae 4 weight portion, Herba lysimachiae capillipedis 15 weight portion, Radix Wikstroemae 2 weight portion, Rhizoma Marantae bicoloris 3 weight portion, water hair spends 20 weight portions and Fructus Aristolochiae 20 weight portion.
7. the pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 40 ~ 60 DEG C subsequently under vacuum 0.05 ~ 0.08Mpa, relative density is the mastic of 1.04 ~ 1.12, spraying dry, the inlet temperature 150 ~ 165 DEG C of spray dryer, leaving air temp 70 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 30 ~ 50 DEG C of dryings, obtains granule.
8. the pharmaceutical composition being used for the treatment of pulmonis Bovis seu Bubali inflammation according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 80 ~ 95%, reflux 2 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 2 ~ 4 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.05 ~ 0.2 times, 0.01 ~ 0.12 times of lactose, the starch of 0.01 ~ 0.2 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.02 times of magnesium stearate, granulate, tabletting, makes.
9. the preparation method being used for the treatment of the pharmaceutical composition of pulmonis Bovis seu Bubali inflammation as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 40 ~ 60 DEG C subsequently under vacuum 0.05 ~ 0.08Mpa, relative density is the mastic of 1.04 ~ 1.12, spraying dry, the inlet temperature 150 ~ 165 DEG C of spray dryer, leaving air temp 70 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.3 times in the dried cream powder obtained, makes granule, in 30 ~ 50 DEG C of dryings, obtains granule.
10. the preparation method being used for the treatment of the pharmaceutical composition of pulmonis Bovis seu Bubali inflammation as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, and adding relative to the determining alcohol of mixture quality 1 ~ 3 times is the ethanol of 80 ~ 95%, reflux 2 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 2 ~ 4 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.05 ~ 0.2 times, 0.01 ~ 0.12 times of lactose, the starch of 0.01 ~ 0.2 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.02 times of magnesium stearate, granulate, tabletting, makes.
CN201410750113.3A 2014-12-10 2014-12-10 Pharmaceutical composition for treating bovine pneumonia and preparation method of pharmaceutical composition for treating bovine pneumonia Pending CN104383288A (en)

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CN104825887A (en) * 2015-05-18 2015-08-12 山东新希望六和集团有限公司 Medicament composition for preventing and treating bovine foot and mouth disease and preparation method of medicament composition
CN104873944A (en) * 2015-06-11 2015-09-02 山东新希望六和集团有限公司 Pharmaceutical composition for treating cattle forestomach atony and preparation method thereof
CN106107084A (en) * 2016-07-16 2016-11-16 柳州市安顺养殖专业合作社 A kind of hereford cow feed additive special that can prevent and treat calf streptococcus pneumoniae and preparation method thereof
CN106215008A (en) * 2016-08-26 2016-12-14 任英明 A kind of herbal medicine treating hyopneumoniae

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825887A (en) * 2015-05-18 2015-08-12 山东新希望六和集团有限公司 Medicament composition for preventing and treating bovine foot and mouth disease and preparation method of medicament composition
CN104873944A (en) * 2015-06-11 2015-09-02 山东新希望六和集团有限公司 Pharmaceutical composition for treating cattle forestomach atony and preparation method thereof
CN106107084A (en) * 2016-07-16 2016-11-16 柳州市安顺养殖专业合作社 A kind of hereford cow feed additive special that can prevent and treat calf streptococcus pneumoniae and preparation method thereof
CN106215008A (en) * 2016-08-26 2016-12-14 任英明 A kind of herbal medicine treating hyopneumoniae

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