CN104873947A

CN104873947A - Medicinal composition for treating dog acute upper gastrointestinal hemorrhage and preparation method thereof

Info

Publication number: CN104873947A
Application number: CN201510335546.7A
Authority: CN
Inventors: 张建国
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-17
Filing date: 2015-06-17
Publication date: 2015-09-02

Abstract

The invention discloses a medicinal composition for treating dog acute upper gastrointestinal hemorrhage and a preparation method thereof. The medicinal composition comprises the following raw medicinal materials: water shield, umbilicaria esculenta, tuber of dwarf lilyturf, leaf of omoto nipponlily, gardenia, false lily of the valley, iris, jasminum giraldii diels, prinsepia utilis, helwingia root, disporopsis fuscopicta, spanishneedles herb, kalanchoe, pseudo-ginseng, ginseng, root of red-rooted salvia, radix codonopsis, fiveleaf gynostemma herb, astragalus, white atractylodes rhizome, dried ginger, honeysuckle, fructus forsythiae, frankincense, myrrh and liquoric root. The medicinal composition has the beneficial effects that the main effects are to clear stomach, decrease internal heat and stop bleeding by astringency, the auxiliary effects are to nourish blood and tonify yin, the effects of strengthening the body resistance and eliminating evil can be realized, the immunity of the organism of a diseased dog is improved, and the medicinal composition has the advantages and characteristics of low cost, no medicine residue, pure naturalness, no toxic or harmful effect, high safety, good convenience, complete functions and the like in the aspect of treatment of the acute upper gastrointestinal hemorrhage. The medicinal composition has the advantages of easy and convenient preparation process, small toxic or side effect, convenience in drug administration, good curative effect, good tolerance, easiness in acceptance, easiness in manufacturing of the medicament and low cost.

Description

Be used for the treatment of pharmaceutical composition of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract and preparation method thereof

Technical field

The present invention relates to field of veterinary, particularly relate to and be a kind ofly used for the treatment of pharmaceutical composition of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract and preparation method thereof.

Background technology

Upper gastrointestinal hemorrhage refers to the digestive tract of more than Qu Shi ligament, and what comprise that the pathological changes such as esophagus, Stomach duodenum or pancreas gallbladder cause is hemorrhage, and the jejunum Lesion Hemorrhage after gastrojejunostomy also belongs to this scope.Bleed profusely and refer to that blood loss exceeds 20% of 1000ml or circulating blood volume within a few hours, its clinical main manifestations is hematemesis and (or) melena, often with the acute peripheral circulatory failure that hypovolemia causes, be common emergency case, case fatality rate is up to 8% ~ 13.7%.

The cause of disease: the cause of disease that upper digestive tract is bled profusely is a lot, common person has the infringement of peptic ulcer, Acute Gastric Mucosal, esophagus fundus ventricularis varication and gastric cancer.The cause of disease that upper digestive tract is bled profusely can be summarized as follows:

1. prevalent upper gastrointestinal tract disease

(1) esophagel disease esophagitis, the esophageal carcinoma, esophageal peptic ulcer, esophageal injury etc.

(2) pathological changes etc. after gastroduodenal disease peptic ulcer, acute gastritis, chronic gastritis, prolapse of gastric mucosa, gastric cancer, acute gastric dilatation, duodenitis, Zollinger-Ellison Syndrome, stomach operation.

(3) jejunum disease jejunum crohn, the postoperative jejunal ulcer of gastrointestinal anastomosis.

2. portal hypertension

(1) various cirrhosis patients in decompensation.

(2) Portal Venous Obstruction pylephlebitis, portal thrombosis, portal vein are oppressed by contiguous lump.

(3) Budd-Chiari syndrome.

3. the disease of upper gastrointestinal adjacent organs or tissue

(1) downright bad, the hepatocarcinoma of the biliary tract pressurized that causes of hemobilia bile duct or cholelithiasis, gallbladder or cancer of biliary duct, postoperative bile duct drainage pipe or hepatic aneurysm are broken into biliary tract.

(2) pancreatic diseases involves duodenum cancer of pancreas, the concurrent ruptured abscess of acute pancreatitis.

(3) aneurysm is broken into esophagus, stomach or duodenum, aortic aneurysm, and liver or splenic artery aneurysm are broken.

(4) mediastinal tumor or abscess are broken into esophagus.

4. systemic disease

(1) hematopathy leukemia, thrombocytopenic purpura, hemophilia, disseminated inravascular coagulation and other disturbances of blood coagulation.

(2) uremia.

(3) vascular conditions atherosclerosis, anaphylactoid purpura, hereditary hemorrhagic telangiectasia, pseudoxanthoma elasticum etc.

(4) polyarteritis nodosa systemic lupus erythematosis or other vasculitises.

(5) after stress ulcer septicemia wound, burn or major operation, shock, after Adrenal Glucocorticoid treatment, cerebrovas-cularaccident or other Brain-illness, the stress state that emphysema and pulmonary heart disease etc. cause.

Clinical manifestation: 1. hematemesis and (or) melena

It is the characteristic performance of upper gastrointestinal hemorrhage.Often there are hematemesis and melena in bleeding part the above person of pylorus, and below pylorus, person only can show as melena.But the above pathological changes of the few and slow-footed pylorus of amount of bleeding can rarely seen melena, and the pathological changes below large, the fireballing pylorus of amount of bleeding can flow into stomach because of blood reflux, causes hematemesis.

2. blood loss peripheral circulatory failure

Can be asymptomatic within amount of bleeding 400ml, amount of bleeding is medium causes anemia or Progressive symmetric erythrokeratodermia anemia, dizziness, weakness, stand up suddenly can produce faint, thirsty, limbs creeping chill and blood pressure on the low side etc.Bleed profusely and reach whole body blood volume 30% ~ 50% and can produce shock, show as dysphoria or obnubilation, pale complexion, the limbs being moist and cold, lip cyanosis, dyspnea, blood pressure drops to not detecting, pulse pressure difference reduce and pulse fast and weak etc., if deal with improperly, death can be caused.

3. azotemia.

4. anemia and blood change

All have hemorrhagic anemia after acute massive hemorrhage, in early days hemorrhage, hemoglobin concentration, red blood cell count(RBC) and packed cell volume can without significant changes, and general needs just occurred anemia through more than 3 ~ 4 hours.Massive bleeding from upper digestive tract 2 ~ 5 hours, numeration of leukocyte can obviously raise, and after hemostasis, 2 ~ 3 talentes recover normal.But liver cirrhosis and the high person of spleen, then numeration of leukocyte can not increase.

5. generate heat

Moderate or case of bleeding profusely, in internal heat generation in 24 hours, how below 38.5 degree, last for days to week is not etc.

At present, medicine or surgical hemostasis measure are mainly taked in western medical treatment acute hemorrhage of upper gastrointestinal tract:

Drug therapy: general employing proton pump inhibitor omeprazole, H ₂receptor antagonist cimetidine or ranitidine, or the medicine such as ranitidine, norepinephrine, thrombin, pituitrin,

Western medical treatment does not reach desirable therapeutic effect, and treatment cost is higher.But the acute hemorrhage of upper gastrointestinal tract of Chinese medicine Canis familiaris L. not only has the effects such as the hemostasis of western modern medicine, also there is the effect of clearing stomach pathogenic fire reducing, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill Canis familiaris L., selected natural Chinese medicines material, make drug effect directly arrive focus, the course for the treatment of is shorter, and curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, there is clearing stomach pathogenic fire reducing, anastaltic effect, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill Canis familiaris L., the course for the treatment of is shorter, curative effect is better, and prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.

In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract, described pharmaceutical composition comprises following raw medicinal material: Herba braseniaeel., Umbillcaria esculenta, Radix Ophiopogonis, Folium Rohdeae Japonicae, Fructus Gardeniae, Herba Maianthemi Bifolii, Rhizoma Iridis Tectori, Radix Jasmini Giraldii, Folium Prinsepiae Utilis, Radix Helwingiae, Rhizoma Tupistrae Chinensis, Herba Bidentis Bipinnatae, Herba Kalanchoes Laciniatae, Radix Notoginseng, Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Codonopsis, Herb Gynostemmae Pentaphylli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Flos Lonicerae, Fructus Forsythiae, Olibanum, Myrrha and Radix Glycyrrhizae.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 17-21 weight portion, Umbillcaria esculenta 23-28 weight portion, Radix Ophiopogonis 29-32 weight portion, Folium Rohdeae Japonicae 15-25 weight portion, Fructus Gardeniae 17-21 weight portion, Herba Maianthemi Bifolii 10-15 weight portion, Rhizoma Iridis Tectori 3-8 weight portion, Radix Jasmini Giraldii 19-24 weight portion, Folium Prinsepiae Utilis 7-11 weight portion, Radix Helwingiae 13-26 weight portion, Rhizoma Tupistrae Chinensis 15-27 weight portion, Herba Bidentis Bipinnatae 17-21 weight portion, Herba Kalanchoes Laciniatae 24-34 weight portion, Radix Notoginseng 36-45 weight portion, Radix Ginseng 29-32 weight portion, Radix Salviae Miltiorrhizae 15-27 weight portion, Radix Codonopsis 24-34 weight portion, Herb Gynostemmae Pentaphylli 29-32 weight portion, Radix Astragali 36-45 weight portion, Rhizoma Atractylodis Macrocephalae 15-28 weight portion, Rhizoma Zingiberis 23-28 weight portion, Flos Lonicerae 36-45 weight portion, Fructus Forsythiae 23-28 weight portion, Olibanum 6-12 weight portion, Myrrha 29-32 weight portion and Radix Glycyrrhizae 10-15 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 19 weight portion, Umbillcaria esculenta 25 weight portion, Radix Ophiopogonis 31 weight portion, Folium Rohdeae Japonicae 22 weight portion, Fructus Gardeniae 18 weight portion, Herba Maianthemi Bifolii 13 weight portion, Rhizoma Iridis Tectori 6 weight portion, Radix Jasmini Giraldii 23 weight portion, Folium Prinsepiae Utilis 9 weight portion, Radix Helwingiae 19 weight portion, Rhizoma Tupistrae Chinensis 23 weight portion, Herba Bidentis Bipinnatae 21 weight portion, Herba Kalanchoes Laciniatae 32 weight portion, Radix Notoginseng 39 weight portion, Radix Ginseng 32 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Radix Codonopsis 27 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, the Radix Astragali 42 weight portion, the Rhizoma Atractylodis Macrocephalae 23 weight portion, Rhizoma Zingiberis 26 weight portion, Flos Lonicerae 41 weight portion, Fructus Forsythiae 26 weight portion, Olibanum 7 weight portion, Myrrha 31 weight portion and Radix Glycyrrhizae 13 weight portion.

Described pharmaceutical composition also comprises Radix Rehmanniae, Nodus Nelumbinis Rhizomatis, Radix Angelicae Sinensis, Colla carapax Trionycis and Fructus Corni.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 17-21 weight portion, Umbillcaria esculenta 23-28 weight portion, Radix Ophiopogonis 29-32 weight portion, Folium Rohdeae Japonicae 15-25 weight portion, Fructus Gardeniae 17-21 weight portion, Herba Maianthemi Bifolii 10-15 weight portion, Rhizoma Iridis Tectori 3-8 weight portion, Radix Jasmini Giraldii 19-24 weight portion, Folium Prinsepiae Utilis 7-11 weight portion, Radix Rehmanniae 24-34 weight portion, Nodus Nelumbinis Rhizomatis 30-41 weight portion, Radix Angelicae Sinensis 29-32 weight portion, Radix Helwingiae 13-26 weight portion, Rhizoma Tupistrae Chinensis 15-27 weight portion, Herba Bidentis Bipinnatae 17-21 weight portion, Herba Kalanchoes Laciniatae 24-34 weight portion, Radix Notoginseng 36-45 weight portion, Radix Ginseng 29-32 weight portion, Radix Salviae Miltiorrhizae 15-27 weight portion, Radix Codonopsis 24-34 weight portion, Herb Gynostemmae Pentaphylli 29-32 weight portion, Radix Astragali 36-45 weight portion, Rhizoma Atractylodis Macrocephalae 15-28 weight portion, Rhizoma Zingiberis 23-28 weight portion, Colla carapax Trionycis 15-25 weight portion, Flos Lonicerae 36-45 weight portion, Fructus Forsythiae 23-28 weight portion, Olibanum 6-12 weight portion, Myrrha 29-32 weight portion, Fructus Corni 17-21 weight portion and Radix Glycyrrhizae 10-15 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 19 weight portion, Umbillcaria esculenta 25 weight portion, Radix Ophiopogonis 31 weight portion, Folium Rohdeae Japonicae 22 weight portion, Fructus Gardeniae 18 weight portion, Herba Maianthemi Bifolii 13 weight portion, Rhizoma Iridis Tectori 6 weight portion, Radix Jasmini Giraldii 23 weight portion, Folium Prinsepiae Utilis 9 weight portion, Radix Rehmanniae 27 weight portion, Nodus Nelumbinis Rhizomatis 35 weight portion, Radix Angelicae Sinensis 31 weight portion, Radix Helwingiae 19 weight portion, Rhizoma Tupistrae Chinensis 23 weight portion, Herba Bidentis Bipinnatae 21 weight portion, Herba Kalanchoes Laciniatae 32 weight portion, Radix Notoginseng 39 weight portion, Radix Ginseng 32 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Radix Codonopsis 27 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, the Radix Astragali 42 weight portion, the Rhizoma Atractylodis Macrocephalae 23 weight portion, Rhizoma Zingiberis 26 weight portion, Colla carapax Trionycis 22 weight portion, Flos Lonicerae 41 weight portion, Fructus Forsythiae 26 weight portion, Olibanum 7 weight portion, Myrrha 31 weight portion, Fructus Corni 19 weight portion and Radix Glycyrrhizae 13 weight portion.

In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the pharmaceutical composition of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract, when the dosage form of pharmaceutical composition is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

When the dosage form of pharmaceutical composition is powder, its preparation method comprises the following steps:

The first step, mixes Herba braseniaeel., Umbillcaria esculenta, Radix Ophiopogonis, Folium Rohdeae Japonicae and Fructus Gardeniae in described ratio, and be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filters, obtains the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Jasmini Giraldii, Folium Prinsepiae Utilis, Radix Helwingiae, Rhizoma Tupistrae Chinensis and Herba Bidentis Bipinnatae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The invention has the beneficial effects as follows: medicine composite for curing acute hemorrhage of upper gastrointestinal tract of the present invention is based on clearing stomach pathogenic fire reducing, astringing to arrest bleeding, hold concurrently and help the moon to nourish blood, the immunity of disease Canis familiaris L. can be improved, in treatment acute hemorrhage of upper gastrointestinal tract, there is the advantageous feature such as cheapness, no drug residue, pure natural property, nonhazardous, safe ready, complete function.

Detailed description of the invention

Pharmaceutical composition of the present invention follows the ultimate principle of " strengthening vital QI to eliminate pathogenic factors ", follow clearing stomach pathogenic fire reducing, anastaltic principle, provide one and be used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract pharmaceutical composition, comprise following raw medicinal material: Herba braseniaeel., Umbillcaria esculenta, Radix Ophiopogonis, Folium Rohdeae Japonicae, Fructus Gardeniae, Herba Maianthemi Bifolii, Rhizoma Iridis Tectori, Radix Jasmini Giraldii, Folium Prinsepiae Utilis, Radix Helwingiae, Rhizoma Tupistrae Chinensis, Herba Bidentis Bipinnatae, Herba Kalanchoes Laciniatae, Radix Notoginseng, Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Codonopsis, Herb Gynostemmae Pentaphylli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Flos Lonicerae, Fructus Forsythiae, Olibanum, Myrrha and Radix Glycyrrhizae; Preferably, Radix Rehmanniae, Nodus Nelumbinis Rhizomatis, Radix Angelicae Sinensis, Colla carapax Trionycis and Fructus Corni can also be comprised.Wherein, Herba braseniaeel., Umbillcaria esculenta, Radix Ophiopogonis, Folium Rohdeae Japonicae, Fructus Gardeniae, Herba Bidentis Bipinnatae, Flos Lonicerae, Fructus Forsythiae clearing stomach pathogenic fire reducing, astringing to arrest bleeding; Rhizoma Iridis Tectori, Radix Jasmini Giraldii, Folium Prinsepiae Utilis, Radix Rehmanniae, Nodus Nelumbinis Rhizomatis, Radix Angelicae Sinensis, Radix Helwingiae, Rhizoma Tupistrae Chinensis blood circulation promoting and blood stasis dispelling; Radix Notoginseng, Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Codonopsis, Herb Gynostemmae Pentaphylli, the Radix Astragali, Rhizoma Atractylodis Macrocephalae hemostasis by invigorating QI; Herba Maianthemi Bifolii, Herba Kalanchoes Laciniatae, Flos Lonicerae, Fructus Forsythiae cooling blood for hemostasis; Radix Salviae Miltiorrhizae, Radix Codonopsis, Herb Gynostemmae Pentaphylli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis hold up the spleen governs the blood; Olibanum, Myrrha removing stasis to stop bleeding; Radix Rehmanniae, Nodus Nelumbinis Rhizomatis, Radix Angelicae Sinensis, Colla carapax Trionycis, Fructus Corni, Radix Glycyrrhizae nourish blood and help the moon, use Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Herba braseniaeel.: another name cogongrass ((Book of Songs "), screen (" Songs of the South "), wild duck certain herbaceous plants with big flowers (" Mao Shichuan "), Luan (" Shuowen "), water certain herbaceous plants with big flowers (land pearl not exactly round in shape " poem is dredged "), Herba Oenanthes Javanicae (Important Arts for the People's Welfare), dew certain herbaceous plants with big flowers (" Yan Shi family precepts "), silk Herba braseniaeel. (Tang Materia Medica), Herba Calthae Membranaceae, supraclavicular fossa grass (" experience good recipe "), brocade band (" detailed outline "), horse milletgrass (" modern Practical Chinese medicinal ").For the stem and leaf of nymphaeaceae plant Folium Braseniae Schreberi.Sweet, cold, nontoxic.Enter liver, spleen two warp.Heat clearing away, diuretic, detumescence, removing toxic substances.Control hematodiarrhoea, jaundice, carbuncle, furuncle.

Umbillcaria esculenta: another name cliff flower, ear, stone Auricularia.Lichens Umbilicariaceae Umbilcaria plant Umbillcaria esculenta, is used as medicine with thallus.Sweet, flat.Clearing away heat to stop bleeding, relieving cough and resolving phlegm.For spitting blood, epistaxis, metrorrhagia, cystitis, enteritis, dysentery, bronchitis.Venom is controlled in external, burn and scald.

Radix Ophiopogonis: sweet micro-hardship, cold.Enter lung, stomach, heart channel.Nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, reinforcing stomach reg fluid.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, quenches one's thirst, and calentura Tianjin is hindered, dry mouth and throat, constipation.

Folium Rohdeae Japonicae: bitter and puckery flavor, feeble QI is trembled with fear.Enter kidney channel, specially logical arteries and veins of superintending and directing, also can enter lung.Heart tonifying diuresis, heat-clearing and toxic substances removing, hemostasis.Control heart failure, laryngopharynx swelling and pain, spitting of blood, spit blood, sore, venom.

Fructus Gardeniae: another name Yellow Fructus Gardeniae, HUANGGUOSHU, SHANZHIZI, Fructus Gardeniae.This product is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae, and its root also can be used as medicine.Bitter, cold, nontoxic; Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Shennong's Herbal: " pathogen in main five, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the hot swelling pain of order, the large heat of breast heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt pathogenic fire, eliminating heart-fire and relieving restlessness, the key medicine that calentura is vexed in order to control, restlessness is not peaceful.

Herba Maianthemi Bifolii: Liliaceae dance crane grass platymiscium twoleaf dance crane grass, with all herbal medicine.Xia Qiu gathers, and cleans and dries.Sour in the mouth, puckery, be slightly cold.Removing heat from blood, hemostasis.For spitting blood, hematuria, menorrhagia; Traumatic hemorrhage is controlled in external.

Rhizoma Iridis Tectori: another name Wu Yuan (" not record "), black kite (" detailed outline "), flat bamboo (" Zhiwu Mingshi Tukao "), blue butterfly (" Guangzhou flora "), also profit numb (" Guangxi Chinese veterinarian's medicine is planted ").For the rhizome of irides Rhizoma Iridis Tectori .bitter, pungent, flat.Blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, removing toxic substances, removing food stagnancy.For traumatic injury, rheumatalgia, laryngopharynx swelling and pain, dyspeptic abdominal distention, malaria; Carbuncle furuncle and phyma poison is controlled in external, traumatic hemorrhage.

Radix Jasmini Giraldii: another name Jasminum floridum Bge., mountain are rescued, hair leaf visits the spring.Oleaceae flavin is fragrant, is used as medicine with root.Micro-hardship, puckery, temperature.Blood circulation promoting and blood stasis dispelling, granulation promoting, convergence.Cure mainly traumatic injury, stagnant in blood stasis, fracture, knife injury." Shaanxi Chinese herbal medicine ": " blood circulation promoting and blood stasis dispelling, granulation promoting, convergence.Control traumatic injury, stagnant in blood stasis, fracture, knife injury."

Folium Prinsepiae Utilis: another name gun barrel fruit, milk beats, sponge cake, Flos Mume thorn, bullet fruit, fruit of shooting, A Nasi, Canis familiaris L. milk, Mengzi Folium Prinsepiae Utilis.Source Rosaceae Prinsepia Royle plant Folium Prinsepiae Utilis, is used as medicine with root, leaf and fruit.Bitter, pungent, cool.Root, leaf: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.For lymphadenitis, parotitis, mastitis, rheumatic arthritis, hemorrhoid, traumatic injury, menoxenia, anemia, gingival hemorrhage.

Radix Helwingiae: another name Radix Tiliae (" Guizhou medical herbs "), Helwingia himalaica root (" Yunnan Chinese herbal medicine ").For the blue or green pod leaf of Cornaceae plant, the root of the blue or green pod leaf in Tibet or Helwingia chinensis.Toil, flat.Antiasthmatic-antitussive, blood circulation promoting and blood stasis dispelling.Control cough with asthma, rheumatism, impairment caused by overstrain, menoxenia, traumatic injury.

Rhizoma Tupistrae Chinensis: another name bamboo root ginseng, Rhizoma Tupistrae ensifoliae, oxtail seven (" Shaanxi Chinese herbal medicine ").For the rhizome of liliaceous plant Tupistra chinensis Bak..Nourishing yin and purging fire, promoting blood flow to regulate menstruation.Control consumptive fever cough, rheumatic arthralgia, menoxenia, traumatic injury.

Herba Bidentis Bipinnatae: call terrible hairpin grass (supplement to the Herbal), terrible Hemerocallis citrina Baroni, Shandong lao-ya-tsao (" Fujian traditional herbal medicine "), Herba Bidentis Bipinnatae (" southern Jiangsu seed plant "), terrible spicule (" medicine will is planted in Jiangsu ").For the herb of feverfew Herba Bidentis Bipinnatae.Bitter in the mouth is flat, nontoxic.Heat clearing away, removing toxic substances, dissipating blood stasis, detumescence.Treating malaria disease, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, dysphagic, acute appendicitis, laryngopharynx swelling and pain, traumatic injury, snake bite and insect sting.

Herba Kalanchoes Laciniatae: another name Laciniate Kalanchoe Herb, five pawl Radix Notoginseng, chicken foot Radix Notoginseng, Herba Senecionis Chrysanthemoidis, false Rhizoma Coptidis.Crassulaceae Bryophyllum plant Herba Kalanchoes Laciniatae, with all herbal medicine.Sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For traumatic injury, venom, skin infection abscess, burn and scald, eczema, traumatic hemorrhage.

Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature, enter liver, stomach warp, have hemostasia and dissipation blood stasis, the effect of reducing swelling and alleviating pain, be mainly used in hemoptysis, metrorrhagia etc. various go out blood disorder, blood vessel dilating, to reduce blood pressure, improve microcirculation, increase blood flow, prevention and therapy heart and brain tissues ischemia, anoxia; Promote the synthesis of protein, ribonucleic acid (RNA), DNA (deoxyribonucleic acid) (DNA), building body; Promote blood cell metabolism, balance adjustment blood cell; Two-ways regulation nervus centralis, improves mental, strengthens learning and memory ability; Hemostasis, blood circulation promoting and blood stasis dispelling; Protect the liver, antiinflammatory.

Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor.Return spleen, lung meridian, heart channel.Function strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly that impairment caused by overstrain is deficient, food told in lack of appetite, asthenia, regurgitation, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency be multiple, the disease of all qi-blood-body fluid deficiencies.Radix Ginseng can regulate the balance of central nervous system stimulant process and process of inhibition.There are amphicheirality and Composition Dependence to the impact of learning and memory, there is maincenter and intend choline activity and intend catecholamine active, choline systemic-function can be strengthened, increase synthesis and the release of Ach, improve maincenter M-cholinoceptor density simultaneously.The mechanism of Anti-Fatigue Effects of Panax ginseng may with its rising blood fat and to promote that protein, RNA synthesize relevant.Radix Ginseng active substance also has the reducing property of check melanin simultaneously, makes skin pure white smooth.Its beauty treatment effectiveness is innumerable, is the superfine product of improving looks.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, enters the heart, Liver Channel, has the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, dysmenorrhoea amenorrhea; Stagnation of QI-blood, the symptoms such as trusted subordinate's pain, Radix Salviae Miltiorrhizae can reduce as interior fat and testis peripheral adipose, alleviates insulin secretion and glycometabolic Random early Detection.Strengthen myocardial contraction, improve cardiac function, do not increase myocardial oxygen consumption.Coronary artery dilating, increases myocardial flow; Expansion peripheral blood vessel, blood flow increases; Cerebral blood flow declines, and improves plasmin activity; Extend bleeding and cotting time; Anticoagulant (improve cAMP level in platelet and suppress TXA2 synthesis); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time are shortened).

Radix Codonopsis: property is put down, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, YIN nourishing and the production of body fluid promoting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, and effect person of modern times joins and is more weak, is applicable to various deficiency of vital energy deficiency person.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to human body multi viscera, can improve the adaptability of human body.Have antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After small number of patients is taken medicine, there is the symptom such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.After taking Herb Gynostemmae Pentaphylli, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Air making-up and spleen enlivening, benefit defends real table, ascending up spleen-Qi and Yang, poison holding sore, inducing diuresis to remove edema.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system for the Radix Astragali, soil in tonification.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.There is obvious and lasting diuresis, to various animal as rat, rabbit, Canis familiaris L. have effect.

Rhizoma Zingiberis: this product is the dry rhizome of zingiber.Pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.1. " herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI.2. " not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.3. " property of medicine opinion ": cure mainly nine types of precordial pain, kill three worms, main removing blood stasis, the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, except cough with dyspnea, stagnation of QI, gather around numbness, only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison.

Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.

Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian." property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti.Stick up greatly leaf long and narrow, as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the Chinese toon person of not opening in fact, sticks up outstanding grass as room.On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi is all carefully little like sticking up greatly, and mountain people from south also uses it.Only with sticking up son greatly under modern capital, without stem flower also." pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, be the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, symptom, its bacteriostasis and the Flos Lonicerae broadly similar such as laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.

Olibanum: another name drips Olibanum, smoked Lu Xiang.Burseraceae Boswellia carterii platymiscium Boswellia carterii ,medicine glue XIANGSHU and wild Boswellia carterii etc., be used as medicine with the oleo-gum-resin that its trunk skin zone wound oozes out.Pungent, bitter, temperature.Enter the heart, liver, spleen channel.Removing stasis to stop bleeding, promoting blood circulation and stopping pain granulation promoting.Supplement to the Herbal: " treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine lets out Bleach, treats all skin ulcers and makes internal diabetes." Compendium of Material Medica: " all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured." regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Headed by Olibanum, the uterus ball of taste medicine antibacterially have stronger bacteriostasis than multiple, and effectively can kill infusorian.Therefore all pain of all heart stomach flank limbs joints all can control it.Be apt to again control woman's dysmenorrhea, postnatal blood stasis is had a pain, irregular menstrual cycle.Power that its ventilation is invigorated blood circulation, be apt to control anemofrigid-damp arthralgia again, the whole body is numb, and extremity are unsuccessful and all skin infection are swollen aches, or its skin ulcer is not ached firmly.External be powder with deposited skin infection, can detoxify, detumescence, granulation promoting, to relieve the pain, though the product for opening, unlikely wasting QI-blood, sincere good medicine is also.

Myrrha: another name myrrh, bright Myrrha.The oleo-gum-resin that Burseraceae bdellium plant myrrh and the trunk skin zone belonging to his kind of plant together ooze out.Acrid in the mouth, hardship, property is put down, and GUIXIN, liver, spleen channel, have dissipating blood stasis analgesic therapy, and effect of detumescence and promoting granulation, cures mainly obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, rheumatic arthralgia, traumatic injury, the cards such as carbuncle skin infection.The water logging agent (1:2) of Myrrha has inhibitory action in various degree to multiple pathogenic dermatophytess such as trichophyton, Trichophyton concentricunm, perhaps blue achorion in vitro. and its antibacterial action may be relevant with contained eugenol.Oleo-resins part, to the male rabbit hypercholesterolemia of raising hydrogenated vegetable oil and causing, has the effect reducing cholesterolemia content, and can prevent Mottling formation.Myrrha (generally using tincture) has some local irritant effect, can be used in mouth wass, also can be used for gastrointestinal unable time with excited enterokinesia. Myrrha still can make rabbit body weight alleviate to some extent.Prevent tissue deterioration very effective, especially have the situation of wound gangrene.Its refrigerant function can help corridor, skin ulcer and skin ulcer, can also improve the stream wound of soup and the skin of be full of cracks.Effectively to eczema and the tinea pedis of anti-current soup.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.。Can QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite; Leanness yellowish complexion; Shortness of breath and palpitation; Stomachache loose stool; The anxious pain of extremity contraction; Hysteria; Cough and asthma; Laryngopharynx swelling and pain; Carbuncle skin ulcer swells and ache; Infantile carbuncle; And medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Radix Rehmanniae: another name Radix Rehmanniae (Collective Notes to the Canon of Materia medica), the fresh Radix Rehmanniae (" book on Chinese herbal medicine is just read ").For the fresh rhizome of scrophulariaceae rehmannia glutinosa plant.Sweet, cold; GUIXIN, liver, kidney channel.Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.By by the Radix Rehmanniae with Fructus Amomi, wine, Pericarpium Citri Reticulatae for adjuvant, repeatedly steam and shine to color blackening, quality softness is namely in order to Radix Rehmanniae Preparata, and the LIUWEI DIHUANG WAN having Radix Rehmanniae Preparata to make, be exactly famous the kidney invigorating good medicine, the clinical treatment being also usually used in the diseases such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.

Nodus Nelumbinis Rhizomatis: another name Nodus Nelumbinis Rhizomatis bar.This product is the dry root stipes portion of nymphaeaceae plant lotus.Sweet, puckery, flat.Return liver, lung, stomach warp.Hemostasis, repercussive.For spitting blood, spitting of blood, hematuria, metrorrhagia." detailed outline is picked up any lost article from the road ": " Nodus Nelumbinis Rhizomatis powder: open diaphragm, mends waist kidney, and blood vessels, dissipating blood stasis blood, tissue regeneration promoting blood; Puerperal and haematemesis person's food especially good." control hemoptysis, spit blood, epistaxis, hematuria, has blood in stool, dysentery, metrorrhagia.

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Colla carapax Trionycis: call other nail gelatin.Reptilia Chelonia Trionychidae inchina Trionyx sinensis Wiegmann, is used as medicine with the cream that carapace is brewed into.Salty in the mouth; Cold nature.Return lung; Liver; Kidney channel.Nourishing YIN for decreasing fever; Hard masses softening and resolving.Main deficiency of YIN hectic fever; Asthenia hemoptysis; Chronic malaria; Malaria with splenomegaly; Blood stasis swells and ache; Blood deficiency amenorrhea.

Fructus Corni: sour, puckery, tepor; Enter liver, the heart, kidney three warp.Invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse." Mingyi Bielu " carries: " Fructus Corni tepor, nontoxic.Cure mainly the intestines and stomach ailment said due to cold or exposure, cold and heat hernia abdominal mass ... deafness, the therapeutic method to keep the adverse QI flowing downwards, perspires, benefit essence, settling five organs, logical nine orifices, only normal urination." Materia Medica of Decoction: " and sliding then QI prostration, astringent is so receive it, and Fructus Corni stops normal urination, secret vital essence get its sour-puckery flavor with receive sliding also." invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

Embodiments provide a kind of pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract, be made up of the raw medicinal material of following parts by weight: Herba braseniaeel. 19 weight portion, Umbillcaria esculenta 25 weight portion, Radix Ophiopogonis 31 weight portion, Folium Rohdeae Japonicae 22 weight portion, Fructus Gardeniae 18 weight portion, Herba Maianthemi Bifolii 13 weight portion, Rhizoma Iridis Tectori 6 weight portion, Radix Jasmini Giraldii 23 weight portion, Folium Prinsepiae Utilis 9 weight portion, Radix Helwingiae 19 weight portion, Rhizoma Tupistrae Chinensis 23 weight portion, Herba Bidentis Bipinnatae 21 weight portion, Herba Kalanchoes Laciniatae 32 weight portion, Radix Notoginseng 39 weight portion, Radix Ginseng 32 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Radix Codonopsis 27 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, the Radix Astragali 42 weight portion, the Rhizoma Atractylodis Macrocephalae 23 weight portion, Rhizoma Zingiberis 26 weight portion, Flos Lonicerae 41 weight portion, Fructus Forsythiae 26 weight portion, Olibanum 7 weight portion, Myrrha 31 weight portion and Radix Glycyrrhizae 13 weight portion.

Its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 pharmaceutical composition 2

Embodiments provide a kind of pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract, be made up of the raw medicinal material of following parts by weight: Herba braseniaeel. 19 weight portion, Umbillcaria esculenta 25 weight portion, Radix Ophiopogonis 31 weight portion, Folium Rohdeae Japonicae 22 weight portion, Fructus Gardeniae 18 weight portion, Herba Maianthemi Bifolii 13 weight portion, Rhizoma Iridis Tectori 6 weight portion, Radix Jasmini Giraldii 23 weight portion, Folium Prinsepiae Utilis 9 weight portion, Radix Rehmanniae 27 weight portion, Nodus Nelumbinis Rhizomatis 35 weight portion, Radix Angelicae Sinensis 31 weight portion, Radix Helwingiae 19 weight portion, Rhizoma Tupistrae Chinensis 23 weight portion, Herba Bidentis Bipinnatae 21 weight portion, Herba Kalanchoes Laciniatae 32 weight portion, Radix Notoginseng 39 weight portion, Radix Ginseng 32 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Radix Codonopsis 27 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, the Radix Astragali 42 weight portion, the Rhizoma Atractylodis Macrocephalae 23 weight portion, Rhizoma Zingiberis 26 weight portion, Colla carapax Trionycis 22 weight portion, Flos Lonicerae 41 weight portion, Fructus Forsythiae 26 weight portion, Olibanum 7 weight portion, Myrrha 31 weight portion, Fructus Corni 19 weight portion and Radix Glycyrrhizae 13 weight portion.

Its preparation method is as follows:

The first step, mixes Herba braseniaeel., Umbillcaria esculenta, Radix Ophiopogonis, Folium Rohdeae Japonicae and Fructus Gardeniae in described ratio, and be the dissolve with ethanol of 95% with the determining alcohol of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filters, obtains the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 1 times relative to the mixture quality obtained, reflux was extracted after 1 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Radix Jasmini Giraldii, Folium Prinsepiae Utilis, Radix Helwingiae, Rhizoma Tupistrae Chinensis and Herba Bidentis Bipinnatae are mixed in described ratio, add the ethanol of the determining alcohol 95% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.20, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 4 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 2 times relative to the mixture quality obtained, again heat decoction 2 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.

The toxicity test of embodiment 1 pharmaceutical composition:

1, trial drug

Choose Herba braseniaeel. 19g, Umbillcaria esculenta 25g, Radix Ophiopogonis 31g, Folium Rohdeae Japonicae 22g, Fructus Gardeniae 18g, Herba Maianthemi Bifolii 13g, Rhizoma Iridis Tectori 6g, Radix Jasmini Giraldii 23g, Folium Prinsepiae Utilis 9g, Radix Helwingiae 19g, Rhizoma Tupistrae Chinensis 23g, Herba Bidentis Bipinnatae 21g, Herba Kalanchoes Laciniatae 32g, Radix Notoginseng 39g, Radix Ginseng 32g, Radix Salviae Miltiorrhizae 25g, Radix Codonopsis 27g, Herb Gynostemmae Pentaphylli 30g, Radix Astragali 42g, Rhizoma Atractylodis Macrocephalae 23g, Rhizoma Zingiberis 26g, Flos Lonicerae 41g, Fructus Forsythiae 26g, Olibanum 7g, Myrrha 31g and Radix Glycyrrhizae 13g.Mixing, is ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

The toxicity test of embodiment 2 pharmaceutical composition

1, trial drug

Choose Herba braseniaeel. 19g, Umbillcaria esculenta 25g, Radix Ophiopogonis 31g, Folium Rohdeae Japonicae 22g, Fructus Gardeniae 18g, Herba Maianthemi Bifolii 13g, Rhizoma Iridis Tectori 6g, Radix Jasmini Giraldii 23g, Folium Prinsepiae Utilis 9g, Radix Rehmanniae 27g, Nodus Nelumbinis Rhizomatis 35g, Radix Angelicae Sinensis 31g, Radix Helwingiae 19g, Rhizoma Tupistrae Chinensis 23g, Herba Bidentis Bipinnatae 21g, Herba Kalanchoes Laciniatae 32g, Radix Notoginseng 39g, Radix Ginseng 32g, Radix Salviae Miltiorrhizae 25g, Radix Codonopsis 27g, Herb Gynostemmae Pentaphylli 30g, Radix Astragali 42g, Rhizoma Atractylodis Macrocephalae 23g, Rhizoma Zingiberis 26g, Colla carapax Trionycis 22g, Flos Lonicerae 41g, Fructus Forsythiae 26g, Olibanum 7g, Myrrha 31g, Fructus Corni 19g and Radix Glycyrrhizae 13g.Mixing, is ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

Contrast test

Jiangsu Province's veterinary station accepts ill Canis familiaris L. 342 example of acute hemorrhage of upper gastrointestinal tract for medical treatment in June ,-2014 in February, 2011, all has hematemesis, melena clinical manifestation.Choose 192 ill Canis familiaris L.s and be divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, the ill Canis familiaris L. of three groups all without significant difference, has comparability in body weight, the state of an illness etc.Embodiment group 1, embodiment group 2 and matched group use the powder of the injectable powder of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively; Wherein, injectable powder adopts subcutaneous injection, each 50mg/kg, once a day, and injection 7 days continuously; The using method of powder is mixed in conventional feed by powder according to the part by weight of 3:100, feeds continuously 7 days; Conventional medicament, for using cimetidine 0.6g/ day, point to add that Glucose Liquid is quiet to be pushed away or quiet for 2 times; Norepinephrine is dissolved in for 6 ~ 8mg/ time in ice-cold normal saline oral or through Injection by stomach duct, every day 1 ~ 3 time; Intramuscular injection every day carbazochrome salicylate 10 ~ 20mg; , conventional feed of feeding.Experimental period is 7 days, and the recovery from illness situation of the ill Canis familiaris L. of experimental session record and death toll, calculate average daily gain and cure rate, and result as shown in Table 1 and Table 2.Wherein, recovery from illness: stopped bleeding, continuous 3 days fecal occult blood feminine genders in 1 week; Effective: stopped bleeding, fecal occult blood (+) ~ (++) for three days on end in 1 week; Invalid: clinical symptoms is not improved, treat 1 week haemophilia.

Therapeutic outcome

The therapeutic effect synopsis of Canis familiaris L. suffered from by three groups, table 1

Group	Sum	Recovery from illness number	Significant figure	Invalid number	Effective percentage
						Embodiment group 1	64	59	5	0	100%
Embodiment group 2	64	60	4	0	100%
						Matched group	64	42	13	9	85.9%

Data from table 1: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has advantage that is evident in efficacy, cheap, that have no side effect in the acute hemorrhage of upper gastrointestinal tract for the treatment of Canis familiaris L..

The recovery from illness of three groups, table 2 is suffered from Canis familiaris L. fecal occult blood clearance time and is compared

Group	Sum	Fecal occult blood clearance time hour
			Embodiment group 1	59	50±4
Embodiment group 2	60	48±3
			Matched group	42	135±16

Data from table 2: compared with conventional medicament, medicine average bleeding stopping period in the acute hemorrhage of upper gastrointestinal tract for the treatment of Canis familiaris L. of the embodiment of the present invention 1 and 2 is better than matched group.

Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 has toxic and side effects advantage little, evident in efficacy in the acute hemorrhage of upper gastrointestinal tract for the treatment of Canis familiaris L..

Model case 1

Nanjing certain Canis familiaris L. peaceful, hematemesis and row's melena are gone to a doctor for 18 hours.Hematemesis and row's melena amount about 1800ml altogether.Be diagnosed as acute hemorrhage of upper gastrointestinal tract.The injectable powder giving embodiment 1 immediately adopts subcutaneous injection, each 50mg/kg, once a day; After 34 hours, fecal occult blood the moon turns.Pay a return visit without recurrence after March.

Model case 2

The Canis familiaris L. of Xuzhou grandson, hematemesis 1 row's melena is gone to a doctor for 2 days.Suddenly look into gastroscope prompting: acute hemorrhage of upper gastrointestinal tract (AGML).Start to feed and be added with the feedstuff of the embodiment of the present invention 2 powder, powder is mixed in conventional feed according to 3:100 weight ratio, and within 16 hours, ill Canis familiaris L. symptom is obviously improved, and after 24 hours, fecal occult blood the moon turns.Pay a return visit without recurrence after June.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. be used for the treatment of the pharmaceutical composition of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Herba braseniaeel., Umbillcaria esculenta, Radix Ophiopogonis, Folium Rohdeae Japonicae, Fructus Gardeniae, Herba Maianthemi Bifolii, Rhizoma Iridis Tectori, Radix Jasmini Giraldii, Folium Prinsepiae Utilis, Radix Helwingiae, Rhizoma Tupistrae Chinensis, Herba Bidentis Bipinnatae, Herba Kalanchoes Laciniatae, Radix Notoginseng, Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Codonopsis, Herb Gynostemmae Pentaphylli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Flos Lonicerae, Fructus Forsythiae, Olibanum, Myrrha and Radix Glycyrrhizae.

2. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 17-21 weight portion, Umbillcaria esculenta 23-28 weight portion, Radix Ophiopogonis 29-32 weight portion, Folium Rohdeae Japonicae 15-25 weight portion, Fructus Gardeniae 17-21 weight portion, Herba Maianthemi Bifolii 10-15 weight portion, Rhizoma Iridis Tectori 3-8 weight portion, Radix Jasmini Giraldii 19-24 weight portion, Folium Prinsepiae Utilis 7-11 weight portion, Radix Helwingiae 13-26 weight portion, Rhizoma Tupistrae Chinensis 15-27 weight portion, Herba Bidentis Bipinnatae 17-21 weight portion, Herba Kalanchoes Laciniatae 24-34 weight portion, Radix Notoginseng 36-45 weight portion, Radix Ginseng 29-32 weight portion, Radix Salviae Miltiorrhizae 15-27 weight portion, Radix Codonopsis 24-34 weight portion, Herb Gynostemmae Pentaphylli 29-32 weight portion, Radix Astragali 36-45 weight portion, Rhizoma Atractylodis Macrocephalae 15-28 weight portion, Rhizoma Zingiberis 23-28 weight portion, Flos Lonicerae 36-45 weight portion, Fructus Forsythiae 23-28 weight portion, Olibanum 6-12 weight portion, Myrrha 29-32 weight portion and Radix Glycyrrhizae 10-15 weight portion.

3. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 19 weight portion, Umbillcaria esculenta 25 weight portion, Radix Ophiopogonis 31 weight portion, Folium Rohdeae Japonicae 22 weight portion, Fructus Gardeniae 18 weight portion, Herba Maianthemi Bifolii 13 weight portion, Rhizoma Iridis Tectori 6 weight portion, Radix Jasmini Giraldii 23 weight portion, Folium Prinsepiae Utilis 9 weight portion, Radix Helwingiae 19 weight portion, Rhizoma Tupistrae Chinensis 23 weight portion, Herba Bidentis Bipinnatae 21 weight portion, Herba Kalanchoes Laciniatae 32 weight portion, Radix Notoginseng 39 weight portion, Radix Ginseng 32 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Radix Codonopsis 27 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, the Radix Astragali 42 weight portion, the Rhizoma Atractylodis Macrocephalae 23 weight portion, Rhizoma Zingiberis 26 weight portion, Flos Lonicerae 41 weight portion, Fructus Forsythiae 26 weight portion, Olibanum 7 weight portion, Myrrha 31 weight portion and Radix Glycyrrhizae 13 weight portion.

4. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises Radix Rehmanniae, Nodus Nelumbinis Rhizomatis, Radix Angelicae Sinensis, Colla carapax Trionycis and Fructus Corni.

5. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 17-21 weight portion, Umbillcaria esculenta 23-28 weight portion, Radix Ophiopogonis 29-32 weight portion, Folium Rohdeae Japonicae 15-25 weight portion, Fructus Gardeniae 17-21 weight portion, Herba Maianthemi Bifolii 10-15 weight portion, Rhizoma Iridis Tectori 3-8 weight portion, Radix Jasmini Giraldii 19-24 weight portion, Folium Prinsepiae Utilis 7-11 weight portion, Radix Rehmanniae 24-34 weight portion, Nodus Nelumbinis Rhizomatis 30-41 weight portion, Radix Angelicae Sinensis 29-32 weight portion, Radix Helwingiae 13-26 weight portion, Rhizoma Tupistrae Chinensis 15-27 weight portion, Herba Bidentis Bipinnatae 17-21 weight portion, Herba Kalanchoes Laciniatae 24-34 weight portion, Radix Notoginseng 36-45 weight portion, Radix Ginseng 29-32 weight portion, Radix Salviae Miltiorrhizae 15-27 weight portion, Radix Codonopsis 24-34 weight portion, Herb Gynostemmae Pentaphylli 29-32 weight portion, Radix Astragali 36-45 weight portion, Rhizoma Atractylodis Macrocephalae 15-28 weight portion, Rhizoma Zingiberis 23-28 weight portion, Colla carapax Trionycis 15-25 weight portion, Flos Lonicerae 36-45 weight portion, Fructus Forsythiae 23-28 weight portion, Olibanum 6-12 weight portion, Myrrha 29-32 weight portion, Fructus Corni 17-21 weight portion and Radix Glycyrrhizae 10-15 weight portion.

6. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Herba braseniaeel. 19 weight portion, Umbillcaria esculenta 25 weight portion, Radix Ophiopogonis 31 weight portion, Folium Rohdeae Japonicae 22 weight portion, Fructus Gardeniae 18 weight portion, Herba Maianthemi Bifolii 13 weight portion, Rhizoma Iridis Tectori 6 weight portion, Radix Jasmini Giraldii 23 weight portion, Folium Prinsepiae Utilis 9 weight portion, Radix Rehmanniae 27 weight portion, Nodus Nelumbinis Rhizomatis 35 weight portion, Radix Angelicae Sinensis 31 weight portion, Radix Helwingiae 19 weight portion, Rhizoma Tupistrae Chinensis 23 weight portion, Herba Bidentis Bipinnatae 21 weight portion, Herba Kalanchoes Laciniatae 32 weight portion, Radix Notoginseng 39 weight portion, Radix Ginseng 32 weight portion, Radix Salviae Miltiorrhizae 25 weight portion, Radix Codonopsis 27 weight portion, Herb Gynostemmae Pentaphylli 30 weight portion, the Radix Astragali 42 weight portion, the Rhizoma Atractylodis Macrocephalae 23 weight portion, Rhizoma Zingiberis 26 weight portion, Colla carapax Trionycis 22 weight portion, Flos Lonicerae 41 weight portion, Fructus Forsythiae 26 weight portion, Olibanum 7 weight portion, Myrrha 31 weight portion, Fructus Corni 19 weight portion and Radix Glycyrrhizae 13 weight portion.

7. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

8. the pharmaceutical composition being used for the treatment of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

9. the preparation method being used for the treatment of the pharmaceutical composition of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:

10. the preparation method being used for the treatment of the pharmaceutical composition of Canis familiaris L. acute hemorrhage of upper gastrointestinal tract as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps: