CN105028995A - Mixed dog food and preparation method thereof - Google Patents

Abstract

The invention discloses a mixed dog food and a preparation method thereof. The dog food is prepared from the following raw materials: corn, wheat, millet, distillers dried grains with soluble (DDGS), wheat bran, purple sweet potato powder, cabbage mustard, water spinach, lotus root starch, celery leaves, acorn powder, beet leaves, corn oil, edible salt, vitamin premix and microelement premix; and the preparation method comprises a crushing step, a burdening step and a pelletizing step. The dog food disclosed by the invention has the beneficial effects that the dog food contains traditional Chinese medicinal additives with the effects of clearing the stomach, decreasing internal heat and astringing to stop bleeding; the dog food is capable of strengthening body resistance and eliminating evil, and has the advantages of relatively short treatment course, relatively good curative effect, no medicine residue and low cost; and as the traditional Chinese medicinal additives and other raw materials of the dog food are matched with one another and work together, acute upper gastrointestinal hemorrhage of dogs can be treated, the nutritional requirements of the dogs can also be met, and the mixed dog food especially can meet the nutritional requirements of the dogs with acute upper gastrointestinal hemorrhage.

Description

A kind of cooperation dog grain and preparation method thereof

Technical field

The present invention relates to beasts feed, particularly one coordinates dog grain and preparation method thereof.

Background technology

UGB refers to the alimentary canal of more than Qu Shi ligament, and what comprise that the pathologies such as oesophagus, Stomach duodenum or pancreas courage cause is hemorrhage, and the jejunum Lesion Hemorrhage after gastrojejunostomy also belongs to this scope.Bleed profusely and refer to that blood loss exceeds 20% of 1000ml or CBV within a few hours, its clinical main manifestations is spitting blood and (or) melaena, often with the acute peripheral circulatory failure that hypovolemia causes, be common acute disease, case fatality rate is up to 8% ~ 13.7%.

The cause of disease: the cause of disease that UGI is bled profusely is a lot, common person has the infringement of peptic ulcer, Acute Gastric Mucosal, esophagus fundus ventricularis varication and cancer of the stomach.The cause of disease that UGI is bled profusely can be summarized as follows:

1. prevalent upper gastrointestinal tract disease

(1) esophagel disease esophagitis, the cancer of the esophagus, peptic ulcer of esophagus, esophageal injury etc.

(2) pathology etc. after gastroduodenal disease peptic ulcer, acute gastritis, chronic gastritis, prolapse of gastric mucosa, cancer of the stomach, acute gastric dilatation, duodenitis, zes, stomach operation.

(3) jejunum disease jejunum clone is sick, the postoperative jejunal ulcer of gastrointestinal anastomosis.

2. portal hypertension

(1) various cirrhosis patients in decompensation.

(2) Portal Venous Obstruction pylephlebitis, portal vein thrombosis, portal vein are oppressed by contiguous lump.

(3) Budd-Chiari syndrome.

3. the disease of UGI adjacent organs or tissue

(1) downright bad, the liver cancer of the biliary tract pressurized that causes of hematobilia bile duct or cholecystolithiasis, gall-bladder or cholangiocarcinoma, postoperative bile duct drainage pipe or hepatic aneurysm are broken into biliary tract.

(2) pancreatic disease involves duodenum cancer of pancreas, the concurrent ruptured abscess of acute pancreatitis.

(3) aneurysm is broken into oesophagus, stomach or duodenum, aortic aneurysm, and liver or aneurysm of splenic artery are broken.

(4) mediastinal tumor or abscess are broken into oesophagus.

4. systemic disease

(1) blood disease leukaemia, thrombocytopenic purpura, hemophilia, disseminated intravascular coagulation and other disturbances of blood coagulation.

(2) uremia.

(3) vascular conditions atherosclerotic, anaphylactoid purpura, hereditary hemorrhagic telangiectasia, pseudoxanthoma elasticum etc.

(4) PAN systemic lupus erythematosis or other vasculitises.

(5) after stress ulcer septicemia wound, burn or major operation, shock, after Adrenal Glucocorticoid treatment, cerebrovas-cularaccident or other Brain-illness, the stress situation that pulmonary emphysema and cor pulmonale etc. cause.

Clinical manifestation: 1. spitting blood and (or) melena

It is the characteristic performance of UGB.Often there are spitting blood and melena in bleeding part the above person of pylorus, and below pylorus, person only can show as melena.But the above pathology of the few and slow-footed pylorus of amount of bleeding can rarely seen melena, and the pathology below large, the fireballing pylorus of amount of bleeding can flow into stomach because of blood reflux, causes spitting blood.

2. blood loss peripheral circulatory failure

Can be asymptomatic within amount of bleeding 400ml, amount of bleeding is medium causes anaemia or Progressive symmetric erythrokeratodermia anaemia, dizziness, weak and feeble, stand up suddenly can produce faint, thirsty, limbs creeping chill and blood pressure on the low side etc.Bleed profusely and reach whole body blood volume 30% ~ 50% and can produce shock, show as dysphoria or obnubilation, pale complexion, cold clammy limbs, lip cyanosis, expiratory dyspnea, blood pressure drop to do not detect, pulse pressure difference reduce and pulse fast and weak etc., if deal with improperly, death can be caused.

3. azotemia.

4. anaemia and blood change

All have blood loss anemia after acute massive hemorrhage, in early days hemorrhage, HC, red blood cell count(RBC) and packed cell volume can without significant changes, and general needs just occurred anaemia through more than 3 ~ 4 hours.Massive bleeding from upper digestive tract 2 ~ 5 hours, white blood cell count(WBC) can obviously raise, and after hemostasis, 2 ~ 3 talentes recover normal.But cirrhosis and the high person of spleen, then white blood cell count(WBC) can not increase.

5. generate heat

Moderate or case of bleeding profusely, in internal heat generation in 24 hours, how below 38.5 degree, last for days to week is not etc.

At present, medicine or surgical hemostasis measure are mainly taked in western medical treatment acute hemorrhage of upper gastrointestinal tract:

Drug therapy: general employing proton pump inhibitor Omeprazole, H ₂receptor antagonist Cimetidine or ranitidine, or the medicine such as ranitidine, norepinephrine, fibrin ferment, pituitrin,

Western medical treatment does not reach desirable result for the treatment of, and treatment cost is higher.But the acute hemorrhage of upper gastrointestinal tract of Chinese medicine dog not only has the effects such as the hemostasis of western modern medicine, also there is the effect that fire falls in clearing stomach, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill dog, selected natural Chinese traditional medicines material, make drug effect directly arrive focus, the course for the treatment of is shorter, and curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of cooperation dog grain of Chinese medicine additive containing being used for the treatment of dog acute hemorrhage of upper gastrointestinal tract, adopt the dog grain containing this Chinese medicine additive can overcome the various defects of Chinese medicine of the prior art and Western medicine, there is clearing stomach and fall fire, anastaltic effect, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill dog, the course for the treatment of is shorter, curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.

In order to realize foregoing invention object, the invention provides a kind of cooperation dog grain, described dog grain comprises following raw material: corn, wheat, millet, DDGS, wheat bran, purple sweet potato powder, cabbage mustard, water spinach, lotus root starch, leaf of Herba Apii graveolentis, racahout, beet tops, corn oil, salt, vitamin premix and microelement pre-mix material.

In described dog grain, the parts by weight of each raw material are: corn 40-50 weight portion, wheat 15-25 weight portion, millet 20-30 weight portion, DDGS30-60 weight portion, wheat bran 15-20 weight portion, purple sweet potato powder 25-34 weight portion, cabbage mustard 12-19 weight portion, water spinach 13-17 weight portion, lotus root starch 10-20 weight portion, leaf of Herba Apii graveolentis 22-29 weight portion, racahout 18-27 weight portion, beet tops 9-15 weight portion, corn oil 5-8 weight portion, salt 1-2 weight portion, vitamin premix 0.1-0.5 weight portion and microelement pre-mix material 0.1-0.5 weight portion.

Described dog grain also comprises Chinese medicine additive, in described dog grain, the parts by weight of each raw material are: corn 40-50 weight portion, wheat 15-25 weight portion, millet 20-30 weight portion, DDGS30-60 weight portion, wheat bran 15-20 weight portion, purple sweet potato powder 25-34 weight portion, cabbage mustard 12-19 weight portion, water spinach 13-17 weight portion, lotus root starch 10-20 weight portion, leaf of Herba Apii graveolentis 22-29 weight portion, racahout 18-27 weight portion, beet tops 9-15 weight portion, corn oil 5-8 weight portion, salt 1-2 weight portion, vitamin premix 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 1-3 weight portion.

In described dog grain, the parts by weight of each raw material are: corn 43 weight portion, wheat 19 weight portion, millet 24 weight portion, DDGS48 weight portion, wheat bran 17 weight portion, purple sweet potato powder 29 weight portion, cabbage mustard 16 weight portion, water spinach 15 weight portion, lotus root starch 11 weight portion, leaf of Herba Apii graveolentis 28 weight portion, racahout 22 weight portion, beet tops 13 weight portion, corn oil 7 weight portion, salt 2 weight portion, vitamin premix 0.4 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 2 weight portion.

Described Chinese medicine additive comprises following raw medicinal material: water shield, lichen, the tuber of dwarf lilyturf, omoto nipponlily leaf, cape jasmine, twoleaf beadruby herb, iris, an aromatic plant metioned in ancient books skin, himalayan prinsepia leaf, japanese helwingia root, bamboo root seven, beggar-ticks, Buddhist temple dish, pseudo-ginseng, ginseng, the red sage root, Radix Codonopsis, gynostemma pentaphylla, the Radix Astragali, the bighead atractylodes rhizome, rhizoma zingiberis, honeysuckle, the capsule of weeping forsythia, frankincense, myrrh and Radix Glycyrrhizae.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: water shield 17-21 weight portion, lichen 23-28 weight portion, tuber of dwarf lilyturf 29-32 weight portion, omoto nipponlily leaf 15-25 weight portion, cape jasmine 17-21 weight portion, twoleaf beadruby herb 10-15 weight portion, iris 3-8 weight portion, an aromatic plant metioned in ancient books skin 19-24 weight portion, himalayan prinsepia leaf 7-11 weight portion, japanese helwingia root 13-26 weight portion, bamboo root seven 15-27 weight portion, beggar-ticks 17-21 weight portion, Buddhist temple dish 24-34 weight portion, pseudo-ginseng 36-45 weight portion, ginseng 29-32 weight portion, red sage root 15-27 weight portion, Radix Codonopsis 24-34 weight portion, gynostemma pentaphylla 29-32 weight portion, Radix Astragali 36-45 weight portion, bighead atractylodes rhizome 15-28 weight portion, rhizoma zingiberis 23-28 weight portion, honeysuckle 36-45 weight portion, capsule of weeping forsythia 23-28 weight portion, frankincense 6-12 weight portion, myrrh 29-32 weight portion and Radix Glycyrrhizae 10-15 weight portion.

In described Chinese medicine additive, the parts by weight of each raw medicinal material are: water shield 19 weight portion, lichen 25 weight portion, the tuber of dwarf lilyturf 31 weight portion, omoto nipponlily leaf 22 weight portion, cape jasmine 18 weight portion, twoleaf beadruby herb 13 weight portion, iris 6 weight portion, an aromatic plant metioned in ancient books skin 23 weight portion, himalayan prinsepia leaf 9 weight portion, japanese helwingia root 19 weight portion, bamboo root 7 23 weight portion, beggar-ticks 21 weight portion, Buddhist temple dish 32 weight portion, pseudo-ginseng 39 weight portion, ginseng 32 weight portion, the red sage root 25 weight portion, Radix Codonopsis 27 weight portion, gynostemma pentaphylla 30 weight portion, the Radix Astragali 42 weight portion, the bighead atractylodes rhizome 23 weight portion, rhizoma zingiberis 26 weight portion, honeysuckle 41 weight portion, the capsule of weeping forsythia 26 weight portion, frankincense 7 weight portion, myrrh 31 weight portion and Radix Glycyrrhizae 13 weight portion.

The preparation method of described Chinese medicine additive comprises the following steps:

The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method coordinating dog grain, and described preparation method comprises the following steps:

(1) destruction step: take corn, wheat, millet, DDGS, wheat bran, cabbage mustard, water spinach, leaf of Herba Apii graveolentis and beet tops by ratio of weight and the number of copies, drops into pulverizer and carries out Crushing of Ultrafine, crosses 2.0mm sieve after pulverizing;

(2) batching step: take purple sweet potato powder, lotus root starch, racahout, corn oil, salt, vitamin premix, microelement pre-mix material and Chinese medicine additive according to ratio of weight and number, pulverize with step (1) fine powder obtained to mix, drop into mixer, mix, incorporation time is 30-60s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.

The invention has the beneficial effects as follows: cooperation dog grain of the present invention contains and has the Chinese medicine additive that fire, anastaltic effect fall in clearing stomach, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill dog, there is the course for the treatment of shorter, curative effect is better, the advantages such as prolonged application has no drug resistance, drug residue free, and cost price is cheap, Chinese medicine additive and other dog grain raw materials cooperatively interact, interact, dog acute hemorrhage of upper gastrointestinal tract can not only be treated, the nutritional need of dog can also be met.

Detailed description of the invention

Chinese medicine additive refers to take as the leading factor with the traditional theory of China to the physical property of the Nature Chinese herbal medicine (yin, yang, tremble with fear, freeze, temperature, heat), thing taste (sour, sweet, bitter, peppery, salty) and material relation and with the subjects theory such as raising and feed industry and technology for support, the single and compound Chinese herb feed additive developed or intermixture.From modern pharmacology Epidemiological Analysis, feed addictive based on Chinese herbal medicine effective ingredients, there is the immunologic function and non-specific antimicrobial effect that regulate body, Chinese herbal medicine contains alkaloid, polysaccharide, two class volatile oil, the bioactivator such as organic acid flavones and bioflavonoid of anti-antibacterial composition, to adjustment human body immune function, good effect of improving health conditions.It is reported, polysaccharide has the reaction of promotion thymus gland, stimulates reticuloendothelial cell to improve specific antigen respond; Alkaloid can strengthen body fluid and cellular immune function, and the phagocytic function of stimulating expression of macrophage, two class volatile oil can strengthen the phagocytic function of reticuloendothelial system, and can generate by enhancing antibody, promote antigen-antibody reaction and lymphocyte transformation organic acid, intestines can be regulated interior and prevent the breeding of harmful bacteria and improve the activity of enzyme, animal body intracellular metabolic can normally be carried out.The nutriment of folding Chinese herbal feed additive not only containing some is divided from the theory of modern nutriology, but also contain unknown growth regulator and the pigment of some, there is the biochemical reaction activating body directly or indirectly, strengthen biosynthesis effect, thus promote the production performance of animal.

Chinese medicine additive of the present invention is mainly theoretical according to traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors, theory of traditional Chinese medical science think righting and eliminating evil be two aspects connected each other, righting is in order to eliminating evil, by strengthening the method for healthy tendency, get rid of evils and go out, thus get well, be i.e. so-called " just containing evil in dispelling ".Eliminating evil is in order to righting, eliminates the infringement of paathogenic factor and reaches protection healthy tendency, restorative object, i.e. so-called " heresy is gone just from peace ".Righting and eliminating evil be complementary two aspects.When therefore using the rules for the treatment of of strengthening vital QI to eliminate pathogenic factors, conscientiously to carefully analyze the contrast situation of good and evil strength, know the secondary from the primary, determine righting or eliminating evil, or determine the priority of strengthening vital QI to eliminate pathogenic factors.Generally, righting is used for asthenic symptoms; Eliminating evil for real example; If belong to mixture of asthenia and sthenia card, then answer strengthening vital QI to eliminate pathogenic factors and use, but this taking into account not being righting and eliminating evil half and half, is the primary and secondary emergency will distinguishing actual situation, to determine the primary and secondary, successively of strengthening vital QI to eliminate pathogenic factors.In a word, should with " righting is unlikely stays heresy, eliminating evil just do not causing injury " for degree.

Chinese medicine additive of the present invention follows the general principle of " strengthening vital QI to eliminate pathogenic factors ", follow clearing stomach and fall fire, anastaltic principle, provide a kind of dog grain being used for the treatment of dog acute hemorrhage of upper gastrointestinal tract, it comprises Chinese medicine additive, and Chinese medicine additive comprises following raw medicinal material: water shield, lichen, the tuber of dwarf lilyturf, omoto nipponlily leaf, cape jasmine, twoleaf beadruby herb, iris, an aromatic plant metioned in ancient books skin, himalayan prinsepia leaf, japanese helwingia root, bamboo root seven, beggar-ticks, Buddhist temple dish, pseudo-ginseng, ginseng, the red sage root, Radix Codonopsis, gynostemma pentaphylla, the Radix Astragali, the bighead atractylodes rhizome, rhizoma zingiberis, honeysuckle, the capsule of weeping forsythia, frankincense, myrrh and Radix Glycyrrhizae.Wherein, astringing to arrest bleeding falls fire, in water shield, lichen, the tuber of dwarf lilyturf, omoto nipponlily leaf, cape jasmine, beggar-ticks, honeysuckle, capsule of weeping forsythia clearing stomach; Iris, an aromatic plant metioned in ancient books skin, himalayan prinsepia leaf, japanese helwingia root, bamboo root seven promoting blood circulation; Pseudo-ginseng, ginseng, the red sage root, Radix Codonopsis, gynostemma pentaphylla, the Radix Astragali, bighead atractylodes rhizome hemostasis by invigorating QI; Twoleaf beadruby herb, Buddhist temple dish, honeysuckle, capsule of weeping forsythia cooling blood and hemostasis; The red sage root, Radix Codonopsis, gynostemma pentaphylla, the Radix Astragali, the bighead atractylodes rhizome, rhizoma zingiberis hold up The spleen governs the blood; Frankincense, myrrh removing blood stasis and hemostasis, use Radix Glycyrrhizae coordinating the drug actions of a prescription.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Water shield: another name cogongrass ((Book of Songs "), screen (" Songs of the South "), wild duck certain herbaceous plants with big flowers (" Mao Shichuan "), Luan (" Shuowen "), water certain herbaceous plants with big flowers (land pearl not exactly round in shape " poem is dredged "), Chinese celery (Important Arts for the People's Welfare), dew certain herbaceous plants with big flowers (" Yan Shi family precepts "), silk water shield (Tang Materia Medica), membranaceous marshmarigold herb, supraclavicular fossa grass (" experience good recipe "), brocade band (" detailed outline "), horse milletgrass (" modern Practical Chinese medicinal ").For the cauline leaf of nymphaeaceae plant water shield.Sweet, cold, nontoxic.Enter liver, spleen two warp.Heat-clearing, Li Shui, detumescence, removing toxic substances.Control hot dysentery, jaundice, carbuncle swells, furunculosis.

Lichen: another name cliff flower, ear, stone auricularia auriculajudae.Lichens Umbilicariaceae Umbilcaria plant lichen, is used as medicine with thallus.Sweet, flat.Clearing away heat to stop bleeding, relieving cough and reducing sputum.For spitting blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, cystitis, enteritis, dysentery, bronchitis.Venomous snake bite is controlled in external application, burn and scald.

The tuber of dwarf lilyturf: sweet micro-hardship, cold.Enter lung, stomach, the heart channel of Hang-Shaoyin.Yin nourishing and lung moistening, clear away heart-fire relieving restlessness, reinforcing stomach reg fluid.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung carbuncle, consumptive disease dysphoria with smothery sensation, quenches one's thirst, and pyreticosis Tianjin is hindered, dry throat, constipation.

Omoto nipponlily leaf: bitter and puckery flavor, gas is slightly cold.Enter kidney channel, specially logical arteries and veins of superintending and directing, also can enter lung.Cardiac stimulant diuresis, clearing heat and detoxicating, hemostasis.Control heart failure, abscess of throat, spitting of blood, spit blood, sore, snake bite.

Cape jasmine: another name Yellow Fructus Gardeniae, yellow fruit tree, fructus gardeniae, Fructus Gardeniae.This product is the dry mature fruit of madder wort cape jasmine, and its root also can be used as medicine.Bitter, cold, nontoxic; Enter the heart channel of Hang-Shaoyin, Liver Channel, lung channel, stomach warp, tri-jiao channel.Shennong's Herbal: " perverse trend in main five, pathogenic heat in the stomach gas, flushing wine blister Cha nose, the red impetigo ulcer of white leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the red pain of order heat, the large heat of chest heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cooling blood and hemostasis.Pyreticosis is vexed, irascibility hot eyes, and headache, jaundice with damp-heat pathogen, stranguria, bloody flux hematuria, aphthae, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt fire-evil, purge the sthenic heart-fire and relieving restlessness, the key medicine that pyreticosis is vexed in order to control, dysphoria is not peaceful.

Twoleaf beadruby herb: Liliaceae dance crane grass platymiscium twoleaf dance crane grass, with all herbal medicine.Xia Qiu gathers, and cleans and dries.Taste is sour, puckery, is slightly cold.Cool blood, hemostasis.For spitting blood, hematuria, menorrhalgia; Traumatism and bleeding is controlled in external application.

Iris: another name Wu Yuan (" not record "), black kite (" detailed outline "), flat bamboo (" Illustrated Book on Plants "), blue butterfly (" Guangzhou flora "), also profit numb (" Guangxi Chinese veterinarian's medicine is planted ").For the rhizome of irides iris .bitter, pungent, flat.Promoting blood circulation, expelling wind and removing dampness, removing toxic substances, disappears long-pending.For traumatic injury, rheumatalgia pain, abscess of throat, dyspeptic abdominal distention, malaria; Carbuncle furuncle poison is controlled in external application, traumatism and bleeding.

An aromatic plant metioned in ancient books skin: another name showy jasmine root, mountain are rescued, hair leaf visits the spring.Oleaceae flavine is fragrant, is used as medicine with root.Micro-hardship, puckery, temperature.Promoting blood circulation, myogenic, convergence.Cure mainly traumatic injury, stagnant in hemostasis, fracture, knife wound." Shaanxi Chinese herbal medicine ": " promoting blood circulation, myogenic, convergence.Control traumatic injury, stagnant in hemostasis, fracture, knife wound."

Himalayan prinsepia leaf: another name gun barrel fruit, milk beats, sponge cake, plum blossom thorn, bullet fruit, fruit of shooting, A Nasi, dog milk, Mengzi Prinsepia utilis.Source rose family Prinsepia Royle plant Prinsepia utilis, is used as medicine with root, leaf and fruit.Bitter, pungent, cool.Root, leaf: clearing heat and detoxicating, activating blood circulation and reducing swelling.For adenolymphitis, mumps, mastitis, rheumatic arthritis, hemorrhoid, traumatic injury, irregular menstruation, anaemia, bleeding gums.

Japanese helwingia root: another name tuan linden root (" Guizhou herbal medicine "), Helwingia himalaica root (" Yunnan Chinese herbal medicine ").For the blue or green pod leaf of Cornaceae plant, the root of the blue or green pod leaf in Tibet or Helwingia chinensis.Toil, flat.Antiasthmatic-antitussive is promoting blood circulation and removing blood stasis.Control to cough and breathe heavily, rheumatism, internal lesion caused by overexertion, irregular menstruation, traumatic injury.

Bamboo root seven: another name bamboo root ginseng, rhizoma panasis japonici, oxtail seven (" Shaanxi Chinese herbal medicine ").For the rhizome of liliaceous plant Tupistra.Nourishing yin and purging fire, promoting blood circulation for regulating menstruation.Control labor heat cough, arthralgia due to wind-dampness, irregular menstruation, traumatic injury.

Beggar-ticks: call terrible hairpin grass (supplement to the Herbal), terrible chrysanthemum, Shandong lao-ya-tsao (" Fujian traditional herbal medicine "), Bidens bipinnata (" southern Jiangsu seed plant "), terrible spicule (" medicine will is planted in Jiangsu ").For the herb of feverfew beggar-ticks.Bitter is flat, nontoxic.Heat-clearing, removing toxic substances, the loose stasis of blood, detumescence.Preventing and curing malaria disease, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, dysphagic, acute appendicitis, abscess of throat, traumatic injury, snake bite and insect sting.

Buddhist temple dish: another name Laciniate Kalanchoe Herb, five pawl pseudo-ginseng, chicken pin pseudo-ginseng, Sedum uizoon, false river connect.Crassulaceae Bryophyllum plant Buddhist temple dish, with all herbal medicine.Sweet, micro-hardship, cold.Clearing heat and detoxicating, eliminating stasis to subdue swelling.For traumatic injury, venomous snake bite, sore abscess, burn and scald, eczema, traumatism and bleeding.

Pseudo-ginseng: sweet, the micro-hardship of taste, warm in nature, enter liver, stomach warp, have hemostasia and dissipation blood stasis, the effect of swelling and pain relieving, be mainly used in hemoptysis, uterine bleeding etc. various go out blood trouble, hemangiectasis, to reduce blood pressure, improve microcirculation, increase CBF, prevention and therapy heart and brain tissues ischemic, air hunger; Promote the synthesis of protein, ribonucleic acid (RNA), DNA (DNA), improve the health; Promote blood cell metabolism, balance adjustment blood cell; Bidirectional modulation nervous centralis, improves mental, strengthens learning and memory ability; Hemostasis, promoting blood circulation and removing blood stasis; Protect the liver, anti-inflammatory.

Ginseng: property is flat, sweet, the micro-hardship of taste, tepor.Return spleen, lung channel, the heart channel of Hang-Shaoyin.Function is reinforced vital energy, and multiple arteries and veins takes off admittedly, reinforces the spleen to benefit the lung, promotes the production of body fluid to quench thirst, intelligence development of calming the nerves.Cure mainly that internal lesion caused by overexertion is deficient, food less, burnout, gastric disorder causing nausea tells food, stool lingering diarrhea, void cough that syndrome characterized by dyspnea, spontaneous perspiration are cruelly de-, palpitation with fear, forgetful, dizziness and headache, impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's slowly frightened and for a long time void not again, the disease of all qi-blood-body fluid deficiencies.Ginseng can regulate the balance of central nervous system stimulant process and process of inhibition.There are amphicheirality and Composition Dependence to the impact of learning and memory, there is maincenter and intend choline activity and intend catecholamine active, choline systemic-function can be strengthened, increase synthesis and the release of Ach, improve maincenter M-choline receptor density simultaneously.The mechanism of Anti-Fatigue Effects of Panax ginseng may with its rising blood fat and to promote that protein, RNA synthesize relevant.Ginseng active material also has the reducing property of check melanin simultaneously, makes skin pure white smooth.Its beauty treatment effectiveness is innumerable, is the superfine product of improving looks.

The red sage root: bitter, cold in nature, enters the heart, Liver Channel, has promoting blood circulation and removing blood stasis, removing blood stasis for promoting tissue regeneration, the peaceful heart of cool blood effect, be mainly used in the ambition of stagnation of QI and blood, the shouting pain of the chest side of body, uncomfortable in chestly breathes hard, abdominal distension; The irregular menstruation of women's qi and blood discord, closes through dysmenorrhoea; Stagnation of QI-blood, the symptoms such as trusted subordinate's pain, the red sage root can reduce as interior fat and testis peripheral adipose, alleviates insulin secretion and glycometabolic Random early Detection.Strengthen myocardial contractive power, improve cardiac function, do not increase MCO.Coronary artery dilating, increases MBF; Expansion peripheral vascular, blood flow increases; Cerebral blood flow (CBF) declines, and improves plasmin activity; Extend bleeding and cotting time; Antiaggregating activity on platelet (improve cAMP level in blood platelet and suppress TXA2 synthesis); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time are shortened).

Radix Codonopsis: property is put down, sweet, the micro-acid of taste; Return spleen, lung channel.Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung, nourishing Yin and promoting production of body fluid.Weak for the spleen deficiency syndrome of the lung, palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, and function reinforces the spleen to benefit the lung, and effect person of modern times joins and is more weak, is applicable to various deficiency of vital energy deficiency person.Contained saponin(e, synanthrin, Alkaloid, starch etc. have strong effect in various degree to human body multi viscera, can improve the adaptability of human body.Have antiulcer, can increase intestines tension force, regulate stomach motion, the stomach of reusing Radix Codonopsis in coordinating intestines and stomach preparation adjusts refreshing agent to chronic diarrhea, and ulcerative colitis, antral gastritis, atrophic gastritis etc. quite have effect.

Gynostemma pentaphylla: taste is sweet, bitter, cold nature; Return lung channel, the spleen channel, kidney channel.The beneficial gas of energy, calms the nerves, hypotensive, clearing heat and detoxicating, cough-relieving apophlegmatic.After small number of patients is taken medicine, there is the symptom such as n and V, abdominal distension diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.After taking gynostemma pentaphylla, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Air making-up and spleen enlivening, benefit defends real table, yang invigorating, holds in the palm malicious sore, inducing diuresis for removing edema.Essentials of Matea Medica: " Radix Astragali, raw with solid table, losslessly to send out, to have sweat to stop; Process with bowl spares, beneficial vigour, strong taste.Green blood, myogenic, apocenosis Neto, sore carbuncle panacea.Variola does not rise, and the deficiency of yang should it without hot person." " book on Chinese herbal medicine justice ": " temperature supports taste, and all middle gas is depressed for the Radix Astragali, soil in help, and spleen soil is weak, and the clear gas person of sinking is the most suitable.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function shows arrest sweating, inducing diuresis for removing edema admittedly, the apocenosis of holder sore, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and adder-wort peripheral vessel, make skin blood overactive circulation; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumopniae, shigella dysenteriae etc.

The bighead atractylodes rhizome: taste is sweet, bitter, warm in nature, enters spleen, stomach warp, has tonifying spleen profit gas, eliminating dampness Li Shui, strengthening exterior and reducing sweat, the fortune spleen effect of moisturizing, and cures mainly the caused ruffian of the dysfunction of the spleen in transport, QI failing to transform into body fluid and has one's mind filled with and rush down, phlegm and retained fluid oedema; The vexed lazyness speech of the deficiency of qi in middle-jiao, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, abnormal sweating spontaneous perspiration, the bighead atractylodes rhizome can promote gastric secretion, strengthens the absorption of small intestine, has regulating action to gastrointestinal function.There is obvious and lasting diuresis, to various animal as rat, rabbit, dog have effect.

Rhizoma zingiberis: this product is the dry rhizome of zingiber.Pungent, hot.Return spleen, stomach, kidney, the heart, lung channel.Rhizoma zingiberis warming spleen and stomach for dispelling cold, Hui Yang promotes blood circulation, eliminating dampness dissolving phlegm.For coldness and pain in the epigastrium, vomiting is had loose bowels, and the cold weak pulse of limb, phlegm and retained fluid is breathed with cough.Mend fire supporing yang, let the fire back to its origin, eliminating cold to stop pain, activating blood to promote menstruation.Warming spleen and stomach, removing internal cold, promoting blood circulation.Control the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb, yang depletion is collapsed, and stomachache is had loose bowels, and cold hernia is run quickly globefish, waist knee crymodynia, through closing abdominal mass, and cloudy subcutaneous ulcer, streamer, and empty sun is more floating, heat in the upper and cold in the lower.1. " herbal classic ": Your Majesty's gas is coughed inverse, tie gas larynx numbness and tell suction, sharp joint, tonifying middle-Jiao and Qi.2. " not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.In main temperature, benefitting liver and lung gas, trusted subordinate's fever and chills, cold disease, choleraic myospasm, headache, pain in the back, only saliva, cough ， Bi Weng; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.3. " property of medicine opinion ": cure mainly nine kinds pained, kill three worms, main broken blood, the tonneau moon closes, and controls weak foot, numbness, meciless, and placenta retension is inverse except coughing, and knot gas, gathers around numbness, and only cold air in abdomen, unbearably painful, main diarrhea, nasal polyp.Herbicide wood poison.

Honeysuckle: cold in nature, taste is sweet, enters lung, the heart, stomach warp, has effect that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind, cures mainly disease under turgor, warm disease heating, the diseases such as hot malicious large carbuncle and tumour.The illnesss such as it is dizzy for giddy, dry is done yearningly, hidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin infection, ulcer furunculosis, erysipelas, mumps, suppurative tonsillitis all have certain curative effect.Lonicera flower tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have anti-infective effect to old man and children.So, often take honeysuckle and to soak or decoction is conducive to wind fire hot eyes, abscess of throat, obesity, liver heat symptom-complex and the hypertensive treatment of liver pattern of fever and rehabilitation.

The capsule of weeping forsythia: bitter, cold nature; Enter the heart, lung, small intestinl channel." property of medicine opinion ": " main tonneau five drenches, urinary obstruction, except heart man visitor heat." Tang Materia Medica: " capsule of weeping forsythia has two kinds, sticks up greatly, littlely to stick up.Stick up greatly leaf long and narrow, as wood, brightly yellowish lovely, give birth to wetland, work, like the Chinese toon person of not opening in fact, sticks up outstanding grass as room.On its little Qiao Sheng hilllock is former, Ye Huashi is all carefully little like sticking up greatly, and mountain people from south also uses it.Only with sticking up son greatly under modern capital, without stem flower also." pharmacological action such as have antibacterial, cardiac stimulant, diuresis, town to tell, be clearing heat and detoxicating Chinese medicine, cure mainly pyreticosis from the beginning of, anemopyretic cold, heating, vexed, symptom, its bacteriostasis and the honeysuckle broadly similar such as abscess of throat, acute nephritis, carbuncle sore tumefacting virus.

Frankincense: another name drips frankincense, smoked Lu Xiang.Burseraceae Boswellia carterii platymiscium Boswellia carterii ,medicine glue Xiang Shu and wild Boswellia carterii etc., be used as medicine with the oleo-gum-resin that its trunk skin zone wound oozes out.Pungent, bitter, temperature.Enter the heart, liver, the spleen channel.Removing blood stasis and hemostasis, promoting blood circulation and stopping pain myogenic.Supplement to the Herbal: " treat deaf, keep silent in middle air port, married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine lets out Bleach, treats in the order of all sores and disappear." Compendium of Material Medica: " all poison of the ulcer that disappears, the heart is protected in Tuoli, and analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured." regulating qi and activating blood, analgesic therapy, chases after poison.Control qi and blood stagnation, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhoea, postpartum blood stasis shouting pain.Headed by frankincense, the uterus ball of taste medicine antibacterially have stronger bacteriostasis than multiple, and effectively can kill trichomonad.Therefore all pain of all heart stomach flank limbs joints all can control it.Be apt to again control woman's dysmenorrhea, postpartum blood stasis is had a pain, irregular menstrual cycle.Power that its ventilation is invigorated blood circulation, be apt to control wind-cold-dampness arthralgia again, the whole body is numb, and four limbs are unsuccessful and all sores are swollen aches, or its sore is not ached firmly.External application be powder with deposited sore, can detoxify, detumescence, myogenic, to relieve the pain, though the product for opening, unlikely wasting QI-blood, sincere good medicine is also.

Myrrh: another name myrrh, bright myrrh.The oleo-gum-resin that Burseraceae bdellium plant myrrh and the trunk skin zone belonging to his Plants together ooze out.Taste is pungent, bitter, and property is put down, the thoughts of returning home, liver, the spleen channel, and have loose stasis of blood analgesic therapy, effect of detumescence and promoting granulation, cures mainly chest impediment and cardialgia, gastral cavity pain, dysmenorrhoea amenorrhoea, arthralgia due to wind-dampness, traumatic injury, and carbuncle swells the cards such as sore.The water logging agent (1:2) of myrrh has inhibitory action in various degree to multiple pathogenic dermatophytes such as trichophyton, Trichophyton concentricums, perhaps blue achorion in vitro. and its antibacterial action may be relevant with contained Eugenol.Oleo-resins part, to the male rabbit hypercholesterolemia of raising hydrogenated vegetable oil and causing, has the effect reducing cholesterolemia content, and can prevent Mottling formation.Myrrh (generally using tincture) has some local irritant effect, can be used in mouth wass, also can be used for stomach and intestine unable time with excited enterocinesia. myrrh still can make rabbit body weight alleviate to some extent.Prevent tissue deterioration very effective, especially have the situation of wound gangrene.Its refrigerant function can help corridor, skin ulcer and sore, can also improve the stream wound of soup and the skin of be full of cracks.Effectively to eczema and the athlete's foot of anti-current soup.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung channel." herbal classic " is said: " main the five internal organs six mansion fever and chills perverse trend, hard muscles and bones, longue meat, times power, metal-inflicted wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " crymodynia in main abdomen, controls frightened epilepsy, except distention and fullness in the abdomen; Help the five internal organs; Make all medicines poison; Support kidney qi internal injury, make impotence; Housewife's human blood drop pain in the back; Empty and how heat; Add and with it ".Can beneficial gas bowl spares, relieving spasm to stop pain, moistens the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription.Main burnout food is few, flesh thin Huang, palpitation, stomachache loose stool, and the anxious pain of four limbs contraction, hysteria, cough and asthma, abscess of throat, carbuncle sore swells and ache, infant fetal toxin, and medicine, food poisoning.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.。Can beneficial gas bowl spares; Relieving spasm to stop pain; Moisten the lung and relieve the cough; Purging intense heat and detonicating; Coordinating the drug actions of a prescription.Main burnout food is few; Flesh thin Huang; Palpitation; Stomachache loose stool; The anxious pain of four limbs contraction; Hysteria; Cough and asthma; Abscess of throat; Carbuncle sore swells and ache; Infant fetal toxin; And medicine, food poisoning.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 Chinese medicine additive

Get water shield 19 weight portion, lichen 25 weight portion, the tuber of dwarf lilyturf 31 weight portion, omoto nipponlily leaf 22 weight portion, cape jasmine 18 weight portion, twoleaf beadruby herb 13 weight portion, iris 6 weight portion, an aromatic plant metioned in ancient books skin 23 weight portion, himalayan prinsepia leaf 9 weight portion, japanese helwingia root 19 weight portion, bamboo root 7 23 weight portion, beggar-ticks 21 weight portion, Buddhist temple dish 32 weight portion, pseudo-ginseng 39 weight portion, ginseng 32 weight portion, the red sage root 25 weight portion, Radix Codonopsis 27 weight portion, gynostemma pentaphylla 30 weight portion, the Radix Astragali 42 weight portion, the bighead atractylodes rhizome 23 weight portion, rhizoma zingiberis 26 weight portion, honeysuckle 41 weight portion, the capsule of weeping forsythia 26 weight portion, frankincense 7 weight portion, myrrh 31 weight portion and Radix Glycyrrhizae 13 weight portion.

Preparation method comprises the following steps:

The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, adds hot reflux 1 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 2 times to be again the ethanol of 90%, to add hot reflux 3 hours that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders, obtain Chinese medicine additive powder.

Embodiment 2 dog grain

Embodiments provide a kind of cooperation dog grain, in dog grain, the parts by weight of each raw material are: corn 43 weight portion, wheat 19 weight portion, millet 24 weight portion, DDGS48 weight portion, wheat bran 17 weight portion, purple sweet potato powder 29 weight portion, cabbage mustard 16 weight portion, water spinach 15 weight portion, lotus root starch 11 weight portion, leaf of Herba Apii graveolentis 28 weight portion, racahout 22 weight portion, beet tops 13 weight portion, corn oil 7 weight portion, salt 2 weight portion, vitamin premix 0.4 weight portion and microelement pre-mix material 0.3 weight portion.

Its preparation method comprises the following steps:

(1) destruction step: take corn, wheat, millet, DDGS, wheat bran, cabbage mustard, water spinach, leaf of Herba Apii graveolentis and beet tops by ratio of weight and the number of copies, drops into pulverizer and carries out Crushing of Ultrafine, crosses 2.0mm sieve after pulverizing;

(2) batching step: take purple sweet potato powder, lotus root starch, racahout, corn oil, salt, vitamin premix and microelement pre-mix material according to ratio of weight and number, pulverize with step (1) fine powder obtained to mix, drop into mixer, mix, incorporation time is 50s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.

Embodiment 3 dog grain

Embodiments provide a kind of cooperation dog grain, in dog grain, the parts by weight of each raw material are: corn 43 weight portion, wheat 19 weight portion, millet 24 weight portion, DDGS48 weight portion, wheat bran 17 weight portion, purple sweet potato powder 29 weight portion, cabbage mustard 16 weight portion, water spinach 15 weight portion, lotus root starch 11 weight portion, leaf of Herba Apii graveolentis 28 weight portion, racahout 22 weight portion, beet tops 13 weight portion, corn oil 7 weight portion, salt 2 weight portion, vitamin premix 0.4 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 2 weight portion; Wherein Chinese medicine additive is the Chinese medicine additive powder of embodiment 1.

Its preparation method comprises the following steps:

(1) destruction step: take corn, wheat, millet, DDGS, wheat bran, cabbage mustard, water spinach, leaf of Herba Apii graveolentis and beet tops by ratio of weight and the number of copies, drops into pulverizer and carries out Crushing of Ultrafine, crosses 2.0mm sieve after pulverizing;

(2) batching step: take purple sweet potato powder, lotus root starch, racahout, corn oil, salt, vitamin premix, microelement pre-mix material and Chinese medicine additive according to ratio of weight and number, pulverize with step (1) fine powder obtained to mix, drop into mixer, mix, incorporation time is 50s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.

The toxicity test of Chinese medicine additive:

1, trial drug

Choose water shield 19g, lichen 25g, tuber of dwarf lilyturf 31g, omoto nipponlily leaf 22g, cape jasmine 18g, twoleaf beadruby herb 13g, iris 6g, an aromatic plant metioned in ancient books skin 23g, himalayan prinsepia leaf 9g, japanese helwingia root 19g, bamboo root seven 23g, beggar-ticks 21g, Buddhist temple dish 32g, pseudo-ginseng 39g, ginseng 32g, red sage root 25g, Radix Codonopsis 27g, gynostemma pentaphylla 30g, Radix Astragali 42g, bighead atractylodes rhizome 23g, rhizoma zingiberis 26g, honeysuckle 41g, capsule of weeping forsythia 26g, frankincense 7g, myrrh 31g and Radix Glycyrrhizae 13g mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filter residue; Again add in 1400g cold water by filtering the filter residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtered fluid, obtaining the second filtrate; Merge twice filtrate, reduced pressure concentration remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the changes of weight of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range (NR), without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Contrast test

Veterinary station of Jiangsu Province accepts ill dog 342 example of acute hemorrhage of upper gastrointestinal tract in June ,-2014 in February, 2011 for medical treatment, all has spitting blood, melena clinical manifestation.Choose 150 ill dogs and be divided into three groups at random, be respectively embodiment group 1 embodiment group 2 and control group, the ill dog of three groups all without significant difference, has comparativity in body weight, the state of an illness etc.Embodiment group 1 and embodiment group 2 and control group use the dog grain of the embodiment of the present invention 2, the dog grain of embodiment 3 and traditional dog grain to feed ill dog respectively; feed continuously 7 days; wherein, control group also needs to use conventional medicament namely to use cimetidine 0.6g/ day, point to add that Glucose Liquid is quiet to be pushed away or quiet for 2 times; Norepinephrine is dissolved in for 6 ~ 8mg/ time in ice-cold normal saline oral or through Injection by stomach duct, every day 1 ~ 3 time; Intramuscular injection every day adrenobazonum 10 ~ 20mg.The recovery from illness situation of the ill dog of experimental session record and death toll, calculate average daily gain and cure rate, and result as shown in Table 1 and Table 2.Wherein, recovery from illness: stopped bleeding, in 1 week, fecal occult blood is negative for three days on end; Effective: stopped bleeding, fecal occult blood (+) ~ (++) for three days on end in 1 week; Invalid: clinical symptoms are not improved, treat 1 week haemophilia.

The result for the treatment of table of comparisons of table 1 three groups of dogs

Group	Sum	Recovery from illness number	Significant figure	Invalid number	Efficient
						Embodiment group 1	50	44	4	2	96%
Embodiment group 2	50	48	2	0	100%
						Control group	50	33	10	7	86%

Data from table 2: compared with conventional medicament, the dog grain of the embodiment of the present invention 2 and embodiment 3 has advantage that is evident in efficacy, cheap, that have no side effect in the acute hemorrhage of upper gastrointestinal tract for the treatment of dog.

The recovery from illness of three groups, table 2 is suffered from dog fecal occult blood clearance time and is compared

Group	Sum	Fecal occult blood clearance time hour
			Embodiment group 1	44	54±6
Embodiment group 2	48	44±3
			Control group	33	136±11

Data from table 2: compared with conventional medicament, dog grain average bleeding stopping period in the acute hemorrhage of upper gastrointestinal tract for the treatment of dog of the embodiment of the present invention 2 and embodiment 3 is better than control group.

Known by contrast test: compared with conventional medicament, the dog grain of the embodiment of the present invention 2 and embodiment 3 has toxic and side effect advantage little, evident in efficacy in the acute hemorrhage of upper gastrointestinal tract for the treatment of dog.

Model case

In January, 2014, dog spitting blood 3 row's melenas of jiangsu wuxi grandson were gone to a doctor, through looking into gastroscope prompting: acute hemorrhage of upper gastrointestinal tract (AGML) for 3 days.The dog grain of the embodiment of the present invention of feeding immediately 3, after 12 hours, dog symptom is obviously improved, and after 24 hours, fecal occult blood the moon turns.Pay a return visit without recurrence after June.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. one kind coordinates dog grain, it is characterized in that, described dog grain comprises following raw material: corn, wheat, millet, DDGS, wheat bran, purple sweet potato powder, cabbage mustard, water spinach, lotus root starch, leaf of Herba Apii graveolentis, racahout, beet tops, corn oil, salt, vitamin premix and microelement pre-mix material.

2. cooperation dog grain according to claim 1, it is characterized in that, in described dog grain, the parts by weight of each raw material are: corn 40-50 weight portion, wheat 15-25 weight portion, millet 20-30 weight portion, DDGS30-60 weight portion, wheat bran 15-20 weight portion, purple sweet potato powder 25-34 weight portion, cabbage mustard 12-19 weight portion, water spinach 13-17 weight portion, lotus root starch 10-20 weight portion, leaf of Herba Apii graveolentis 22-29 weight portion, racahout 18-27 weight portion, beet tops 9-15 weight portion, corn oil 5-8 weight portion, salt 1-2 weight portion, vitamin premix 0.1-0.5 weight portion and microelement pre-mix material 0.1-0.5 weight portion.

3. cooperation dog grain according to claim 1 and 2, it is characterized in that, described dog grain also comprises Chinese medicine additive, in described dog grain, the parts by weight of each raw material are: corn 40-50 weight portion, wheat 15-25 weight portion, millet 20-30 weight portion, DDGS30-60 weight portion, wheat bran 15-20 weight portion, purple sweet potato powder 25-34 weight portion, cabbage mustard 12-19 weight portion, water spinach 13-17 weight portion, lotus root starch 10-20 weight portion, leaf of Herba Apii graveolentis 22-29 weight portion, racahout 18-27 weight portion, beet tops 9-15 weight portion, corn oil 5-8 weight portion, salt 1-2 weight portion, vitamin premix 0.1-0.5 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 1-3 weight portion.

4. the cooperation dog grain according to any one of claim 1-3, it is characterized in that, in described dog grain, the parts by weight of each raw material are: corn 43 weight portion, wheat 19 weight portion, millet 24 weight portion, DDGS48 weight portion, wheat bran 17 weight portion, purple sweet potato powder 29 weight portion, cabbage mustard 16 weight portion, water spinach 15 weight portion, lotus root starch 11 weight portion, leaf of Herba Apii graveolentis 28 weight portion, racahout 22 weight portion, beet tops 13 weight portion, corn oil 7 weight portion, salt 2 weight portion, vitamin premix 0.4 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 2 weight portion.

5. the cooperation dog grain according to any one of claim 1-4, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: water shield, lichen, the tuber of dwarf lilyturf, omoto nipponlily leaf, cape jasmine, twoleaf beadruby herb, iris, an aromatic plant metioned in ancient books skin, himalayan prinsepia leaf, japanese helwingia root, bamboo root seven, beggar-ticks, Buddhist temple dish, pseudo-ginseng, ginseng, the red sage root, Radix Codonopsis, gynostemma pentaphylla, the Radix Astragali, the bighead atractylodes rhizome, rhizoma zingiberis, honeysuckle, the capsule of weeping forsythia, frankincense, myrrh and Radix Glycyrrhizae.

6. the cooperation dog grain according to any one of claim 1-5, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: water shield 17-21 weight portion, lichen 23-28 weight portion, tuber of dwarf lilyturf 29-32 weight portion, omoto nipponlily leaf 15-25 weight portion, cape jasmine 17-21 weight portion, twoleaf beadruby herb 10-15 weight portion, iris 3-8 weight portion, an aromatic plant metioned in ancient books skin 19-24 weight portion, himalayan prinsepia leaf 7-11 weight portion, japanese helwingia root 13-26 weight portion, bamboo root seven 15-27 weight portion, beggar-ticks 17-21 weight portion, Buddhist temple dish 24-34 weight portion, pseudo-ginseng 36-45 weight portion, ginseng 29-32 weight portion, red sage root 15-27 weight portion, Radix Codonopsis 24-34 weight portion, gynostemma pentaphylla 29-32 weight portion, Radix Astragali 36-45 weight portion, bighead atractylodes rhizome 15-28 weight portion, rhizoma zingiberis 23-28 weight portion, honeysuckle 36-45 weight portion, capsule of weeping forsythia 23-28 weight portion, frankincense 6-12 weight portion, myrrh 29-32 weight portion and Radix Glycyrrhizae 10-15 weight portion.

7. the cooperation dog grain according to any one of claim 1-6, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: water shield 19 weight portion, lichen 25 weight portion, the tuber of dwarf lilyturf 31 weight portion, omoto nipponlily leaf 22 weight portion, cape jasmine 18 weight portion, twoleaf beadruby herb 13 weight portion, iris 6 weight portion, an aromatic plant metioned in ancient books skin 23 weight portion, himalayan prinsepia leaf 9 weight portion, japanese helwingia root 19 weight portion, bamboo root 7 23 weight portion, beggar-ticks 21 weight portion, Buddhist temple dish 32 weight portion, pseudo-ginseng 39 weight portion, ginseng 32 weight portion, the red sage root 25 weight portion, Radix Codonopsis 27 weight portion, gynostemma pentaphylla 30 weight portion, the Radix Astragali 42 weight portion, the bighead atractylodes rhizome 23 weight portion, rhizoma zingiberis 26 weight portion, honeysuckle 41 weight portion, the capsule of weeping forsythia 26 weight portion, frankincense 7 weight portion, myrrh 31 weight portion and Radix Glycyrrhizae 13 weight portion.

8. the cooperation dog grain according to any one of claim 1-7, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:

The first step, mixes in proportion by described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive.

9. the preparation method of the cooperation dog grain according to any one of claim 1-8, it is characterized in that, described preparation method comprises the following steps:

(1) destruction step: take corn, wheat, millet, DDGS, wheat bran, cabbage mustard, water spinach, leaf of Herba Apii graveolentis and beet tops by ratio of weight and the number of copies, drops into pulverizer and carries out Crushing of Ultrafine, crosses 2.0mm sieve after pulverizing;

(2) batching step: take purple sweet potato powder, lotus root starch, racahout, corn oil, salt, vitamin premix, microelement pre-mix material and Chinese medicine additive according to ratio of weight and number, pulverize with step (1) fine powder obtained to mix, drop into mixer, mix, incorporation time is 30-60s;

(3) granulation step: drop into granulator and granulate, pelleting temperature is 85 DEG C, makes its gelatinization degree reach more than 90%.