CN101797326B - Chinese materia medica preparation for treating borborygmus diarrhoea and preparation method thereof - Google Patents
Chinese materia medica preparation for treating borborygmus diarrhoea and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese materia medica preparation for treating borborygmus diarrhoea and a preparation method thereof. The Chinese materia medica preparation comprises the following components: Chinese pulsatilla root, common yam rhizome, stir-fried gordon euryale seed, parslane herb, costus root, nutmeg, largehead atractylodes rhizome, poria, voilet, longstamen onion bulb, areca peel, golden thread and tangerine peel. When the patient also obviously suffers from lumbago, cold intolerance, hypogastric pain and diarrhoea when getting up in the morning, the Chinese materia medica preparation is added with cassia bark, south dodder seed, Chinese magnoliavine fruit and rehmannia glutinosa. When the patient suffers from obvious bellyache, abdominal distension and pain reduction after diarrhoea, the Chinese materia medica preparation is added with officinal magnolia bark, bitter orange, white paeony root, kudzu-vine root and divaricate saposhnikovia root. When the patient suffers from poor appetite and apepsia, the Chinese materia medica preparation is added with charred triplet and chicken's gizzard-membrane. The Chinese materia medica preparation of the invention has effects of calming the liver and relieving pain, regulating Qi and strengthening the spleen, tonifying spleen, lungs and kidney, tonifying middle-Jiao and Qi and lifting yang and relieving diarrhea, mainly treats symptoms of acute and chronic enteritis, colonitis, borborygmus diarrhoea caused by liver-yang hyperactivity and weak spleen and stomach, poor appetite and loose stools, limb tiredness and hypodynamia, pain releasing after diarrhoea, repeated attacks and the like, has simple formula and low manufacturing cost and can be popularized and used.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of treatment borborygmus diarrheal Chinese medicine preparation.
Background technology
Diseases such as every clinically volvulus, intestinal intussusception, intestinal adhesion, intestinal neoplasms, bellyworm block cause intestines to risk one's life teeth and nail and wriggle, and intestinal is linked up in attempt again, thereby the bowel sound hyperaction phenomenon just comes one after another.When the intestinal flora imbalance, various antibacterials are fermented at enteral, produced a large amount of gas, it is excessive to make that the interior content of gastrointestinal produces amplitude, or transnormal moving, so borborygmus will occur.Just usually said bowel sound hyperaction.
Common people be hungry belly can be tiptop all be normal; But, increases the borborygmus number of times if having significantly; Per minute reaches more than 15 times, and sound equipment obviously increases, and occurs sometimes " gur gling "; Have strand air-flow on the water surface, to impact and the out-of-date sound that sends seemingly, that just is called bowel sound hyperaction.For the serious patient of borborygmus even can occur just as jingle sound or metallic sound as the metal bump.Hyperfunction along with borborygmus, a burst of tormina can appear in patient, and abdominal part also can be seen intestines and become lifting as the section shape, medically is referred to as " visible peristalsis visible intestinal peristalsis ".Bowel sound hyperaction is strong " signal " of mechanical intestinal obstruction.
General borborygmus all are because the intestinal flora imbalance causes, because various antibacterials are fermented at enteral, have produced a large amount of gas, and it is excessive to make that the interior content of gastrointestinal produces amplitude, or transnormal moving, so borborygmus will occur.But and deposit many symptoms, and duration of seizure above person in accumulative total January.The existence that just indicates enteritis, gastritis.This type patient is easier to occur dyspepsia, can not fully absorb nutrition, causes the loss of nutrition and the supply of necessary nutrition on the one hand, cause bigger harm certainly will for normal psychological need.Especially Ms and friend person in middle and old age, in case the similar state of an illness appears, light malnutrition then, and heavy then dehydration causes insomnia, the colour of skin is dark yellow, becomes thin chronic disease acute attack or increase the weight of the state of an illness.Continuously March the person, be easier to cause the gastrointestinal inflammation of vicious cycle.
If borborygmus performance individualism, its cause of disease mainly is a dyspepsia.The intestinal aerogenesis is too much, and can not smooth and easyly circulate.Hazardness is less.Be main mainly in the treatment with astringency or conditioning medicine.Do not eat too many meat, the food of high protein at ordinary times, do more physical exercises.Eat fresh vegetables, fruit more.For adult borborygmus, when the intestinal flora imbalance, the especially harmful bacterium of various antibacterials is fermented at enteral, produced a large amount of gas, it is excessive to make that the interior content of gastrointestinal produces amplitude, or transnormal moving, so borborygmus will occur.Just usually said intestinal is hyperfunction.
So, increasing probiotics in the body, the growth that suppresses harmful bacterium is only at all.The symptom of enteritis is a lot, and borborygmus scarcely can individualism.Be with a lot of symptoms such as abdominal distention, bowel dysfunction, stomachache under the more situation and deposit that the patient must early find early treatment.The clinical also more gastrointestinal symptoms such as stomachache, diarrhoea, constipation occur of following.Its cause is a functional gastrointestinal disorder.Psychological abnormalities such as anxiety, depression occur as the patient, various psychotic disorders such as melancholy are also followed during hysteria borborygmus diarrheal symptom to occur.The quickening of Along with people's rhythm of life, this disease is the trend of rising.
The Therapeutic Method that adopts at present mainly contains the psychotherapy, Diet Therapy and Drug therapy.Because modern medicine is not clear and definite yet for its pathology and pathogenesis, it is passive to make that the chemical drugs treatment is absorbed in.Though chemical drugs, the tool curative effect of listing are often accompanied certain side effect at present, make the psychotherapy in the treatment of primary disease, occupy very consequence.
The traditional Chinese medical science thinks that borborygmus diarrhoea belongs to " diarrhea before dawn ", " chronic dysentery " category more.Treat this disease at present, doctor trained in Western medicine generally all adopts injection of antibiotics and useful mushroom, and radical rate is low, is prone to recurrence, and is prone to have side effects; The corresponding disease of western medicine; Being main with dioctahedral smectite, motilium, cisapride, A Luosiqiong etc. mainly, only is to treat to borborygmus, diarrheal table disease, does not deep-cut and carefully seizes; Be not based upon whole conditioning; Under the double prerequisite of controlling of body and mind,, take for a long time and can also produce the side effect that lets doctor and patient all worry so curative effect is general.Chinese patent medicine is used Spleen Invigorating and Intestine Tonifying Pill, JIECHANGYAN WAN and the intestines and stomach Yiganning capsule etc. always, and effect neither be very desirable.The traditional Chinese medical science thinks that its pathogenesis is because deficiency of spleen-YANG and kidneyYANG, weakness of the spleen and stomach, and hyperactive liver-QI attacking the stomach, therefore of excessive eating and drinking and the cold-damp summer-heat exopathogen impairment of the spleen etc. answer suppressing the hyperactive liver pain relieving, regulating qi-flowing for strengthening spleen, spleen reinforcing lung kidney, invigorating the spleen and replenishing QI and yang invigorating antidiarrheal, can cure this type of disease.
Summary of the invention
Technical problem to be solved by this invention is; A kind of simple, that processing technology is easy treatment borborygmus diarrheal Chinese medicine preparation and preparation method thereof of filling a prescription is provided; Suppressing the hyperactive liver pain relieving, regulating qi-flowing for strengthening spleen, spleen reinforcing lung kidney, invigorating the spleen and replenishing QI and yang invigorating antidiarrheal can be good at curing borborygmus diarrhoea type disease.
For solving the problems of the technologies described above, the present invention provides a kind of treatment borborygmus diarrheal Chinese medicine preparation, and the ratio of weight and number of various components is: 10～20 parts of the Radix Pulsatillaes, 10～20 parts of Rhizoma Dioscoreaes; 10～20 parts of Semen Euryales (parched), 10～15 parts of Herba Portulacaes, 10～20 parts of Saussurea lappa Clarke, 10～20 parts of Semen Myristicaes; 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts in Poria, 10～20 parts of Herba Violaes, 10～20 parts of Bulbus Allii Macrostemonis; 10～20 parts of Pericarpium Arecae, 10～15 parts of Rhizoma Coptidis, 10～20 parts of Pericarpium Citri Reticulataes.
Said treatment borborygmus diarrheal Chinese medicine preparation rose and promptly rushes down obvious person and can in prescription, add 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Cuscutae, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts in Radix Rehmanniae Preparata when sufferer companion lumbago, fear of cold, few abdomen cold type of pain, morning.
Said treatment borborygmus diarrheal Chinese medicine preparation when the sufferer companion obviously suffers from abdominal pain, abdominal distention, rushes down back alleviation of pain person and can in prescription, add 10～20 parts of Cortex Magnoliae Officinalis, 10～20 parts of Fructus Aurantiis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Puerariaes, windproof 10～20 parts.
Said treatment borborygmus diarrheal Chinese medicine preparation is when sufferer companion poor appetite is not eaten, the person of eating without digesting can add each 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 10～15 parts of Endothelium Corneum Gigeriae Galli in prescription.
The dosage form of said treatment borborygmus diarrheal Chinese medicine preparation can for: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, drop or patch.
Said treatment borborygmus diarrheal Chinese medicine preparation, its dosage form is that the method for preparing of capsule comprises: a takes by weighing the component medical material and adds water extraction 2 times, becomes the extractum shape, is component 1;
It is the extractum shape that the b medicinal residues add the ethanol thickening filtration, is component 2;
C becomes dried cream with above-mentioned two kinds of extractum concentrate dryings, mixes and pulverizes, and it is an amount of to add starch, mixing, fill capsule.
Among the said step a, take by weighing the component medical material and can add water logging bubble 1-2 hour that 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1.
Among the said step b, medicinal residues can add the 60-90% soak with ethanol 0.5-1.5 hour, extracted twice, each 1-2 hour; Merge extractive liquid, filters, and concentrates; The 80-160 order filters, and the 6000-10000 rev/min of supernatant after centrifugal is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams; Ultrafiltrate concentrating under reduced pressure relative density is the extractum of 1.35 (80 ℃), heating and refluxing extraction 2 times, each 30 minutes～45 minutes; Extract active ingredient, 2 extracting solution merging are settled into the extractum shape, as component 2.
Said treatment borborygmus diarrheal Chinese medicine preparation, its dosage form is that the method for preparing of honey pill agent comprises:
The component medical material of said Chinese medicine preparation was soaked 30 minutes to 1 hour, and heated and boiled 30～40 minutes is filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the third time, filters; Three filtratings are lumped together, and heating is concentrated into pasty state, puts into 70 ℃～80 ℃ oven dry of baking oven postcooling, dries postcooling, and mixing with Mel is twisted into slice; With 5g is ball wax seal packing.
Said treatment borborygmus diarrheal Chinese medicine preparation is fried in shallow oil decoction in use and is taken, can every day 1 dose, and decocting is obeyed at twice, and per 7 days is a course of treatment; When this Chinese medicine preparation is pill, capsule or tablet when using, can three times on the one, per 10 days is a course of treatment.
Borborygmus diarrheal Chinese medicine preparation of the present invention has suppressing the hyperactive liver pain relieving, regulating qi-flowing for strengthening spleen, spleen reinforcing lung kidney, invigorating the spleen and replenishing QI and yang invigorating antidiarrheal effect; Treating acute and chronic enteritis and colitis, are rushed down back pain and are relaxed diseases such as outbreak repeatedly at the borborygmus diarrhoea that liver-yang hyperactivity and weakness of the spleen and stomach cause, anorexia and loose stool, lassitude of the limbs and weakness.
The specific embodiment
The traditional Chinese medical science thinks that enteritis belongs to " diarrhea before dawn ", " chronic dysentery " category.The diarrhoea of treatment borborygmus at present, doctor trained in Western medicine generally all adopts injection of antibiotics and useful mushroom, and radical rate is low, is prone to recurrence, and is prone to have side effects; Chinese patent medicine is used Spleen Invigorating and Intestine Tonifying Pill, JIECHANGYAN WAN and the intestines and stomach Yiganning capsule etc. always, and effect neither be very desirable.The traditional Chinese medical science thinks that its pathogenesis is because deficiency of spleen-YANG and kidneyYANG, weakness of the spleen and stomach, and hyperactive liver-QI attacking the stomach, therefore of excessive eating and drinking and the cold-damp summer-heat exopathogen impairment of the spleen etc. answer suppressing the hyperactive liver pain relieving, regulating qi-flowing for strengthening spleen, spleen reinforcing lung kidney, invigorating the spleen and replenishing QI and yang invigorating antidiarrheal, can cure this type of disease.Through clinical observation, inventor of the present invention finds that this Chinese medicine preparation suffers from diarrhoea for borborygmus, and diseases such as acute chronic enteritis and colitis have splendid therapeutic effect, have alleviated the symptom of various discomforts, and the while is not found untoward reaction.Chinese medicine thinks that borborygmus diarrhoea is depression of liver-QI, due to the dysfunction of the spleen in transportation.Liver controlling conveyance and dispersion, the happiness bar reaches, emptiness of spleen and stomach, multiple unsuccessful because of mood, it is angry to be worried, psychentonia, so that depression of liver-QI, functional activity of QI being not smooth is lost it and is reached, and perverse and unreasonable manner is taken advantage of spleen, and it is not normal to cause the fortuneization conduction, appearing suffers from abdominal pain disease such as have loose bowels.Jing-Yue Complete Works draws Liu's grass window side, and the side is made up of the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae and windproof four flavors; Scheme with the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae and windproof four Chinese medicine thing treatment " pain is rushed down disease " also is provided in " Medical Treasures of the Golden Chamber ".Four medicines match, can spleen reinforcing soil and eliminating pathogen in the liver is wooden, and the regulating QI machine rushes down with pain relieving.Be used to treat borborygmus diarrhoea, the stool diarrhea is rushed down all diseases of back stomachache.But the medicine of above ancient prescription all adopts ripe medicine, the particularly Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Pericarpium Citri Reticulatae concocted to be " processing " article.
The corresponding disease of western medicine; Being main with dioctahedral smectite, motilium, cisapride, A Luosiqiong etc. mainly, only is to treat to stomachache, diarrheal table disease, does not deep-cut and carefully seizes; Be not based upon whole conditioning; Under the double prerequisite of controlling of body and mind,, take for a long time and can also produce the side effect that lets doctor and patient all worry so curative effect is general.The medicine that the present invention set forth not only can be treated the misery of health, can also regulate the slight illness of psychology, and taking does not for a long time have toxic and side effects, and raw material is of high quality and at a reasonable price to be easy to get.Rhizoma Atractylodis Macrocephalae ability air making-up and spleen enlivening and dampness diuretic, the abdominal distention that is used for Deficiency and coldness of spleen and stomach is had loose bowels; The Radix Paeoniae Alba can the suppressing the hyperactive liver pain relieving and astringing YIN to stop sweating, is used for disharmony between the liver and spleen, stomachache and has loose bowels etc.; Poria ability promoting diuresis to eliminate damp pathogen and spleen-benefiting mind-tranquilizing are used for diarrhea due to hypofunction of the spleen; Rhizoma Dioscoreae can supplementing QI and nourishing YIN and spleen reinforcing lung kidney.Be used for weakness of the spleen and stomach and antidiarrheal etc.; Pericarpium Citri Reticulatae can regulating qi-flowing for strengthening spleen, is used for irritability and takes advantage of spleen, and stomachache is had loose bowels etc.; Semen Euryales, Saussurea lappa Clarke can astringe the lung nourishing kidney and arresting seminal emission antidiarrheal are used for incessant chronic diarrhea; Radix Puerariae, Herba Violae ability promoting the production of body fluid to quench thirst and yang invigorating antidiarrheal; All medicine compatibilities, the effect of playing heat-clearing and toxic substances removing, dispelling wind and heat pathogens, relieving sore throat and diminishing swelling and nourishing YIN and moistening the lung altogether.The Radix Pulsatillae in the side, Herba Portulacae, the QI invigorating yin fluid astringing helps QI invigorating to give birth to the power of the moon; The Rhizoma Atractylodis Macrocephalae is nourshing Yin and drynsessmoistening prescription, clearing heat and relieving fidgetness; Poria, reinforcing spleen and kidney, medicine carrying is up, Bulbus Allii Macrostemonis, Pericarpium Arecae, Cortex Magnoliae Officinalis makes the efficacy of a drug up, but qi and blood circulation promotion is grown and oiliness all medicines, and benefit is not stayed the stasis of blood; Fructus Aurantii blood stasis dispelling dehumidifying; The Pericarpium Citri Reticulatae appetite-stimulating indigestion-relieving, the Radix Puerariae heat clearing away disappears tired, and JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) and Endothelium Corneum Gigeriae Galli strengthening the spleen to promote digestion are the treatment anorexia, the good medicine of food stagnation.
Radix Pulsatillae bitter in the mouth, cold in nature; Return stomach, large intestine channel; Has heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, the effect of removing dampness and killing parasites; Cure mainly pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, the carbuncle skin ulcer, the scrofula Radix Pulsatillae is a key medicine of controlling amebic dysentery, and is single heavy dose of with, promptly produces effect.Using into square Radix Pulsatillae Decoction always, is principal agent with these article promptly, cooperates Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini to form the both available amebic dysentery of controlling, the also available bacillary dysentery of controlling." book on Chinese herbal medicine justice " carries it: Radix Pulsatillae mildly bitter flavor and light, the clear light weight of gas, " herbal classic " though the bitter temperature of meaning, so pyrexial malaria is mad to be prone to cure mainly, and Zhong Jing and specially to control diarrhea of heat type with tenesmus, then the Bi Feiwen medicine can be known.Its main pyretic toxicity dysentery can let out admittedly though say hardship, and elevate a turnable ladder taste clearing heat in QI system makes and does not sag, and then tenesmus all removes, really the tangible true essence of this medicine.
The Herba Portulacae sour in the mouth; Heat-clearing and toxic substances removing cold in nature; Eliminating pathogenic heat from blood to cure dysentery; It is treating stranguria to dehumidify.These article have heat-clearing and toxic substances removing, damp eliminating leukorrhagia stopping effect, are applicable to that damp invasion of lower energizer, leucorrhea with yellow discharge, sticky flavor are smelly, oliguria with yellow urine, thirsty bitter taste, red tongue with yellow fur, rolling pulse person, also can be used for diarrhea due to damp-heat, dysentery etc.
The Saussurea lappa Clarke another name Radix Aucklandiae, Radix Aucklandiae (Radix Vladimiriae) for feverfew Saussurea lappa Clarke (Aucklandia lappaDecne.), are used as medicine with root.The property of medicine is hot, bitter, temperature.Return spleen, stomach, large intestine, three warmers, gallbladder meridian.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Be used for breast gastral cavity distending pain, heavy behind the dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Saussurea lappa Clarke.Stomachache is used to have loose bowels.Gastrointestinal tract is had excitement or suppresses two-way function, have the secretion of facilitating digestion liquid, function of gallbladder promoting, lax tracheal smooth muscle, antibacterial, diuresis, etc. effect.
Bulbus Allii Macrostemonis is hot, bitter, temperature.Return lung, stomach, large intestine channel.Regulate the flow of vital energy, the chest stuffiness relieving activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, the gastral cavity painful abdominal mass is not relaxed, and retches, and is heavy behind the dysentery, furuncle.Activating YANG and eliminating stagnation, the circulation of qi promoting intestinal stasis relieving.Be used for thoracic obstruction pain, the phlegm retention cough with asthma is let out after the dysentery heavy.Supplement to the Herbal carries it: in the accent, main chronic diarrhea is not recovered, normal evil person in the big abdomen, but cook it more.
Pericarpium Arecae is the dry peel of babassu Semen Arecae, has another name called the Semen Arecae clothing.Main product in Hainan, ground such as Guangxi, Yunnan.Winter to time spring green fruit of gathering is boiled after drying, and vertical profile two lobes strip peel, practise and claim " Pericarpium Arecae ".Acrid in the mouth; Slightly warm in nature.Return spleen; Stomach; Large intestine; Small intestine meridian.Modern study, these article have excited gastrointestinal smooth muscle, short digestive tract power effect, and effect such as the fibrinolysis of promotion is arranged." Kaibao Bencao ": the main cold and hot gas abdomen of making a psychological attack, large intestine is stopped up poison, expectorant diaphragm, the belching of acid from stomach.And fry in shallow oil with Jiang Yantong, go into to dredge the gas medicine good." detailed outline ": lowering the adverse flow of QI, aqueous vapor edema in the skin that disappears, beriberi is stopped up contrary, subtertian malaria feeling of fullness, nausea malignant histocytosis feeling of distension and oppression." book on Chinese herbal medicine is new again ": eliminating the pathogens from the lung, easing stomach-QI, dampness removing chases after wind, wide intestinal detumescence, reason waist beriberi, treating malaria disease dysentery.
The Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.Be used for conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.Be used for diseases such as retention of damp-heat in the interior, the intestines and stomach are damp and hot, vomiting, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., can control the card of retention of damp-heat in the interior.To the damp and hot the intestines and stomach of being reluctant to leave, often cooperate the Rhizoma Pinelliae, Caulis Bambusae In Taenia; Join the Radix Aucklandiae, Radix Scutellariae, Radix Puerariae etc. to control dysentery.
Cortex Magnoliae Officinalis is bitter, suffering, temperature.Return spleen, stomach, lung, large intestine channel.The expectorant of effect dampness, the therapeutic method to keep the adverse QI flowing downwards is removed full.Retention of dampness in middle-JIAO, distension and fullness in the abdomen.The bitter dry suffering of these article is loose, ability dampness, and the therapeutic method to keep the adverse QI flowing downwards is removed distension again, is the key medicine of eliminating distension.Normal and Rhizoma Atractylodis, Pericarpium Citri Reticulatae are equal to usefulness, like Pingwei San (" prescription of peaceful benevolent dispensary ") stagnation of QI due to dyspepsia, abdominal distention constipation.But these article therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, consumer product dredge stasis.Normal and Radix Et Rhizoma Rhei, the same usefulness of Fructus Aurantii Immaturus are like Cortex Magnoliae Officinalis three thing soup (" Medical Treasures of the Golden Chamber ").If the constipation with heat retention person joins Radix Et Rhizoma Rhei, Natrii Sulfas, Fructus Aurantii Immaturus, to reach the drastic purgation accumulation of heat, the effect of consumer product dredge stasis, i.e. DACHENGQI TANG (treatise on Febrile Diseases).
The Semen Euryales (parched) reinforcing the kindey to control nocturnal emission, the spleen reinforcing stopping leak.Control seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, loose stool and diarrhea.Invigorating the spleen to arrest diarrhea: be used for diarrhea due to hypofunction of the spleen, often join Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae invigorating the spleen and replenishing QI, similar a bit for nourishing robustness food with Semen Nelumbinis, but the convergence controlling nocturnal emission with astringent drugs effect of Semen Euryales is stronger than Semen Nelumbinis, is applicable to chronic diarrhea and frequent micturition, emission, and the women is with many soreness of waist etc.Chronic diarrhea comprises chronic tuberculosis of intestine, has loose bowels just before dawn etc." Bencao Congxin ": spleen reinforcing is reinforced the kidney, and helps the gas arresting seminal emission.
The Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.Fruit of Fructus Schisandrae Chinensis is made Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.The pharmacological testing proof can be regulated central nervous system's excitement and process of inhibition, promotes body metabolism, regulates the secretion of gastric juice and bile, and hepatitis convalescent period transaminase rising person is had the reduction effect." book on Chinese herbal medicine converges and says ": the medicine that Fructus Schisandrae Chinensis, astringing QI promote the production of body fluid also.So gas that the Tang Materia Medica master restrains the dissipation of deficiency of the lung chronic cough.All deficiency of vital energy dyspnea with rapid respiration, the cough with dyspnea strain, spirit is not enough, and the arteries and veins gesture is hollow, or the impairment caused by overstrain yang-energy; It is thin that limbs are won, or empty gas is superior, spontaneous perspiration frequently, or deficiency of YIN fire inflammation is exhausted by smart unit; Or the exhaustion of YIN YANG-depletion, refreshing scattered pulse takes off, and controls it with Fructus Schisandrae Chinensis, and its acid of salty usefulness is held back and is promoted the production of body fluid, and protects reinforcing premodial qi and does not have spermatorrhea also.So go into lung last, be lowered to kidney, go into the benefit that lung has the Jiyuan of promoting the production of body fluid, going into kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow.
Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." property of medicine opinion " carried it: monarch, and sweet in the mouth, suffering, nontoxic.Can main big migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, sputum is removed in appetizing, removes cold and heat, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery.
Rhizoma Dioscoreae sweet in the mouth, property are put down, and go into lung, spleen, kidney channel; Not dry oiliness, strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating are arranged, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, effect of prolonging life; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, diseases such as phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, red swollen, the obesity of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.Compendium of Material Medica is summarized five big functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Rhizoma Dioscoreae is cooked congee or simmers with crystal sugar and takes after ripe, and, enteritis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: the treatment weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.The lung benefiting nourishing kidney: these article are cold not dry, and sweet in the mouth matter profit can be treated the lung diseases such as quenching one's thirst of decreasing, seminal emission, leukorrhagia of suffering from a deficiency of the kidney.Be described as angle's medicine.
The Pericarpium Citri Reticulatae temperature; Hot, bitter; Returning the bitter substance of spleen, lung meridian Pericarpium Citri Reticulatae is representative " limonoid " with Fructus Citri Limoniae glycosides and bitter principle, and this limonoid flavor is gentle, is prone to be dissolved in water, helps the digestion of food.When Pericarpium Citri Reticulatae is used for cooking dishes.Its bitterness and other tastes are in harmonious proportion each other, can form original in style local flavor.Pericarpium Citri Reticulatae contains compositions such as volatile oil, hesperidin, vitamin B, C, and its contained volatile oil has gentle stimulation to gastrointestinal tract, but the secretion of facilitating digestion liquid is got rid of pneumatosis in the intestinal tube, stimulating appetite.Pericarpium Citri Reticulatae also is a conventional Chinese medicine simply, has spleen invigorating, the drying dampness to eliminate phlegm of ventilation, the effect of separating greasy lasting, stopping nausea and vomiting by lowering the adverse flow of QI.
Semen Myristicae (formal name used at school Myristica fragrans Houtt.) astringent medicinal; Drugs for dispelling internal cold; Qi-activating drug.The property hot bitter in the mouth, temperature.Return spleen; Stomach; Large intestine channel.Effect cures mainly the warming middle-JIAO astringing intestine to stop diarrhea; Promote qi circulation digestion promoting.Be used for diarrhea of deficiency type; Cold-dysentery; Abdominal distention; The lack of appetite vomiting; Dyspepsia does not disappear." Japan hanako materia medica ": in the accent, the therapeutic method to keep the adverse QI flowing downwards, antidiarrheal dysentery, appetizing helps digestion.The outer network of skin, the therapeutic method to keep the adverse QI flowing downwards, alcoholic intoxication is controlled cholera." Kaibao Bencao ": warming middle-JIAO, control accumulation of pathogenic cold trusted subordinate distending pain, the cholera attacked by pestiferous factors, spitting saliva, cold air, the stopping leak that helps digestion, children's's breast is suddenly." detailed outline ": warming the spleen and stomach, Gu large intestine.
Fructus Aurantii is bitter, hot, sour, temperature.Return spleen, stomach warp.The function regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Be used for the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion stops in the phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus." Bencao Jingshu ": Fructus Aurantii, abnormal smells from the patient is led, and is identical generally with Fructus Aurantii Immaturus.But Fructus Aurantii Immaturus shape is little, and its gas is complete, and its property is strong, so kind assigning; Fructus Aurantii shape is big, and its gas looses, and its property is slow, and Gu Qihang is slow slightly, is with the branch of able person's chest and diaphragm lung stomach and goes into large intestine also.Its main air paralysis of itching, easing joint movement ends wind pain person, covers lung governing skin and hair, stomach master muscle; Wind and cold wets in two warps, skin pruritus then, or have a pain, or numb, this medicine has hardship to let out hot diffusing merit; Doublely can draw all wind medicines and go into two dirtyly, so required for controlling wind, ailment said due to cold or exposure is both diffusing, then saves the nature tonneau.It treats the consumptive disease cough, the bored and listless person of back of the body arm, and lid also refers to that wind and cold is strongly fragrant in the part of the body cavity above the diaphragm housing the heart and lungs, then lung qi stagnates and is bored and listless cough.
Radix Puerariae induces sweat and brings down a fever, and promotes the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels.Compendium of Material Medica is carried: Radix Puerariae, cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid puerarin in the Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.The elevate a turnable ladder yang-energy, light clear liter of the antidiarrheal of quenching the thirst Radix Puerariae loose, and the property of medicine rises to be sent out, and willow is lifted yang-energy, and A healthy wind prevails to inspire body, and body fluid cloth is capable.Rise a clear positive air of taste and quench the thirst antidiarrheal dysentery.So being usually used in treating interior-heat quenches one's thirst, measles is sent out not smooth thoroughly, diseases such as diarrhoea, dysentery.
Herba Violae is Violaceae Chinese violet, Herba Violae japonicae; The whole herb with root of leguminous plant Gueldenstaedtia verna, little Gueldenstaedtia verna or gentianaceae plant south China Radix Gentianae (property of medicine of above-mentioned these medicinal herbs is similar, field of Chinese medicines common name Herba Violae, can use with, and also the property of medicine is similar in the present invention, can use with).Can clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Control furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom." the southern regions of the Yunnan Province book on Chinese herbal medicine ": removing blood stasis, separate the carbuncle mange, nine kinds of hemorrhoid, all sore diseases." detailed outline ": cure mainly all carbuncle carbuncle on the back, the furuncle scrofula that swells, innominate toxic swelling, malignant boil." it is former that book on Chinese herbal medicine is asked ": removing heat from blood, detumescence poison.Control the heat in blood flaccidity due to malnutrition of tendons, deposited skin ulcer is wonderful." south of the Five Ridges gather medicinal herbs record ": make cathartic and tell medicine." Chinese herbal medicine is used in Shanghai always ": heat-clearing and toxic substances removing, externally applied toxicity removing detumescence.Control conjunctival congestion and swelling pain, hordeolum is treated pyogenic infections from tumour or sore, acute mastitis, enteritis, diarrhea, venom.
JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is three flavor medicine, i.e. Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown).This three flavors medicine all has the good removing food stagnancyization function that stagnates, but different features is separately arranged.Fructus Hordei Germinatus (parched to brown) has the effect of good digestible starch group food; Fructus Crataegi (parched to brown) is good at treating meat or greasy dyspepsia due to too much; Massa Medicata Fermentata (parched to brown) then is beneficial to digestion rice and flour food.Three medicines share, and can strengthen digestive function significantly.Therefore, the doctor often share three medicines and is called " JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) " clinically.
Fructus Hordei Germinatus forms through barley germination, and Fructus Hordei Germinatus is put in the pot little stir-fry to yellow, sprays clear water, and taking-up is dried, and is Fructus Hordei Germinatus (parched to brown).Fructus Hordei Germinatus (parched to brown) has invigorating the spleen and regulating the stomach, the stagnant merit of soothing liver-QIization, is used to treat that food stagnation does not disappear, disease such as distension and fullness in the abdomen, inappetence, vomiting are had loose bowels.Modern study thinks that rich in starch catabolic enzyme, conversion carbohydrase, fat enzyme, vitamin B etc. have good digestion-aid effect in the Fructus Hordei Germinatus.
Fructus Crataegi, section is dried, and puts big stir-fry to the outer wrinkly face brown of useing force in the pot, inner yellowish-brown for spending, spraying clear water, and taking-up is dried, and is Fructus Crataegi (parched to brown).Oral Fructus Crataegi can increase digestive enzyme, promotes the decomposition and the digestion of fat, to because of eat meat or greasy too much due to distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is good especially.In addition, modern medicines tests shows that Fructus Crataegi has the slow and persistent effect that brings high blood pressure down, but also cholesterol reducing and triglyceride prevent atherosclerosis, but but also the diastole coronary artery increase myocardial contraction, to arrhythmia.Therefore, help preventing and treating hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.
Massa Medicata Fermentata is for whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli) mix after the processed goods that fermentation forms.Get Massa Medicata Fermentata and put to fry in the pot to appearance and be coke black, inner coke yellow, take out, spray the water that disappears, cool, be Massa Medicata Fermentata (parched to brown).Massa Medicata Fermentata forms through fermentation, and the article of all fermentations all have the digestant effect of strengthening the spleen and stomach, therefore, for bad, the feeling of stuffiness in chest abdominal distention of the digestion due to the diet internal injury effect is arranged quite.
Endothelium Corneum Gigeriae Galli is sweet, and is cold.Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli contains gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.Behind the oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and the stomach motion is strengthened, emptying is accelerated.Its acid extraction liquid or decoct can quicken from urine, to get rid of radiostrontium.
Poria is sweet, light, and is flat.GUIXIN, lung, spleen, kidney channel.The function promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful." herbal classic " carried it: " the contrary gas of the main breast side of body, melancholy is angerd frightened heresy and is probably throbbed with fear, and the heart is the knot pain down, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis." " not Lu ": " only quenches one's thirst, likes to sleep, and big abdomen drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open the breast internal organs, transfer visceral-qi, cut down the kidney heresy, long cloudy, physical strength profiting is during guarantor god keeps." " property of medicine opinion ": " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria.″
Semen Cuscutae Gan Xinping goes into liver, kidney channel.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.Be used for caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, diseases such as frequent fetal movement.The function tonification Liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.Being used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen suffers from a deficiency of the kidney and rushes down.
The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.Be that the benefit fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the good medicine of promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; The flushed complexion cold foot; Dizziness and tinnitus; Dispute is rotten broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; The decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; The dysmenorrhea amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; The carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting." not Lu " be carried it: main pained, side of body wind, hypochondriac pain, warm muscle is promoted blood circulation, end tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago is ended saliva, cough; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing is feared.
Radix Rehmanniae Preparata is sweet, tepor.Return liver, kidney channel.Function cures mainly nourishing YIN and supplementing blood, and beneficial essence is filled out marrow.Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair." detailed outline " carries it: " fill out bone marrow, longue meat, promoting generation of vital essence and blood.The tonifying five ZANG-organs internal injury is not enough, promoting blood circulation, and sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments.”
The Radix Paeoniae Alba goes into liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.
Windproof acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Cure mainly the diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.Normal Rhizoma Et Radix Notopterygii, Ramulus Cinnamomi, the anti-wind energy of Rhizoma Curcumae Longae of cooperating rises the spleen sun and antidiarrheal.The clinical common void that has because of taste, tiredness with somnolence, the limbs ache, diarrhea with loose stool, urine frequency person is with raising splenoyang to strengthen stomach soup (" Treatise on the spleen and stomach "), the effect of whenever wining a battle.If because of the wound ailment said due to cold or exposure, edema with the liver involved is taken advantage of spleen, and aqueous-grainy diarrhea, and the person of having loose bowels with tongxieyao formula (" collection of prescriptions with notes " is drawn Liu's grass window side), are got and prevented that the easypro spleen eliminating pathogen in the liver victory of wind energy is wet, are the key medicine of tying-in.The windproof Fructus Aurantii Immaturus (shell) of joining can relieving constipation.The wind gripe water is searched with the windproof clearing heat in QI system that rises spleen like Holy Benevolent Prescriptions by the side, joins Fructus Aurantii, Radix Et Rhizoma Rhei is pleasant with wide intestinal, controls apoplexy and the constipation due to pathogenic wind, the constipation due to disorder of QI that cause, makes positive clearly liter and turbid yin falls.Wang Haogu uses and windproofly to close Rhizoma Atractylodis, Radix Glycyrrhizae for end (refreshing art is loose), with Rhizoma Zingiberis Recens, very light blue decoction, controls the internal injury cold drink, diseases caused by exogenous pathogenic factor cold-evil and person with anhidrosis.The clinical we of getting add Fructus Aurantii (reality), Fructus Hordei Germinatus is controlled stuffy sensation of deftciency type under the heart, and removing with circulation of qi promoting expires, and helping digestion stagnates.
The manufacturing process of the present invention's honey refining pill is: Radix Pulsatillae 1000g, Rhizoma Dioscoreae 1000g, Semen Euryales (parched) 1000g, Herba Portulacae 500g, Saussurea lappa Clarke 1000g; Semen Myristicae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1000g, Herba Violae 1000g; Bulbus Allii Macrostemonis 1000g, Pericarpium Arecae 1000g, Rhizoma Coptidis 500g, Pericarpium Citri Reticulatae 1000g.
Soak medical material 30 minutes to 1 hour, heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 30 minutes for the third time, filters; Three filtratings are lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 75 ℃, and powdered being mixed in right amount with Mel of oven dry postcooling is twisted into slice; With every 5g is ball wax seal packing.
The present invention is when lumbago, fear of cold, few abdomen cold type of pain, the manufacturing process of capsule was when rose and promptly rush down obvious person morning: get Radix Pulsatillae 1000g, Rhizoma Dioscoreae 1000g, Semen Euryales (parched) 1000g, Herba Portulacae 500g, Saussurea lappa Clarke 1000g; Semen Myristicae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1000g, Herba Violae 1000g, Bulbus Allii Macrostemonis 1000g; Pericarpium Arecae 1000g, Rhizoma Coptidis 500g, Pericarpium Citri Reticulatae 1000g, Cortex Cinnamomi 1000g; Semen Cuscutae 1000g, Fructus Schisandrae Chinensis 1000g, the water logging bubble that Radix Rehmanniae Preparata 1000g adding 5-10 doubly measures 1-2 hour extracts 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1; The residue medicinal residues added the 60-90% soak with ethanol 0.5-1.5 hour, extracted twice, and each 1-2 hour, merge extractive liquid; Filter, concentrate, the 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal; Through the molecular weight that dams is the ultrafiltration post ultrafiltration of 5000-10000, and ultrafiltrate concentrating under reduced pressure relative density is the extractum of 1.35 (80 ℃), heating and refluxing extraction 2 times, each 30 minutes～45 minutes; Extract active ingredient, 2 extracting solution merging are settled into the extractum shape, as component 2.Above-mentioned two kinds of extractum concentrate dryings are become dried cream, mix and pulverize, it is an amount of to add starch, mixing, fill capsule
The present invention accompanies obvious stomachache, abdominal distention, and the preparation process of capsule comprises when rushing down the back alleviation of pain: get Radix Pulsatillae 1000g, Rhizoma Dioscoreae 1000g, Semen Euryales (parched) 1000g, Herba Portulacae 500g; Saussurea lappa Clarke 1000g, Semen Myristicae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1000g, Herba Violae 1000g; Bulbus Allii Macrostemonis 1000g, Pericarpium Arecae 1000g, Rhizoma Coptidis 500g, Pericarpium Citri Reticulatae 1000g, Cortex Magnoliae Officinalis 1000g; Fructus Aurantii 1000g, Radix Paeoniae Alba 1000g, Radix Puerariae 1000g, windproof 1000g
Earlier medical material is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 45 minutes, extract active ingredient, 2 extracting solution are merged leave standstill.Again medicinal residues are added 10 times of water gagings, heating and refluxing extraction 3 times each 1 hour, merges 3 extracting solution; Merge above-mentioned two kinds of extracting solution, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrating is about 1.06 (20 ℃); Above-mentioned filtrating is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes solvent, obtains the component medicine earlier; Incapsulate and be made as capsule, every capsules dress 0.3g.Can per 12 be one edition.
The present invention is when disease sees that poor appetite is not eaten, manufacturing process as the powder Chinese patent medicine during person of eating without digesting is: get each 1000g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Endothelium Corneum Gigeriae Galli 500g, Radix Pulsatillae 1000g, Rhizoma Dioscoreae 1000g, Semen Euryales (parched) 1000g; Herba Portulacae 500g, Saussurea lappa Clarke 1000g, Semen Myristicae 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Poria 1000g; Herba Violae 1000g, Bulbus Allii Macrostemonis 1000g, Pericarpium Arecae 1000g, Rhizoma Coptidis 500g, Pericarpium Citri Reticulatae 1000g; Said component mixes by proportioning, drops into pulverizer and is ground into fine powder, puts into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures; Flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrating after the separation, and heating is concentrated into pasty state; Put into baking oven, be controlled at 100 ℃, the oven dry postcooling is pulverized the back with every bag of 4～6g packing.
The pharmacology pharmacodynamic experiment:
1, acute toxicity test
The application mice carries out acute toxicity testing and shows: mice oral administration gavage Chinese medicine preparation capsule of the present invention; Under 488.8g crude drug/kg dosage; The light activity minimizing appears in mice after the administration; Recover normal about 1 hour, observed 7 days none animal dead after the administration continuously; Its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage Chinese medicine preparation capsule of the present invention is 488.8g crude drug/kg/d (LD 50＞488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
2, long term toxicity test
Select the SD rat for use; Give variable concentrations (18.0,6.0, the Chinese medicine preparation pill of the present invention of 2.0g crude drug/kg), irritate stomach every day once, continuous 90 days; Respectively organized 1/2 animal (male and female half and half) extremely that lives in 24 hours after the last administration, all the other 1/2 animals continuation observation, 2 all backs are extremely alive.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days with carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and check with indexs such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dose groups animal general state, all no abnormal variation of outward appearance sign, behavioral activity, food-intake and body weight gain; Three dose groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, do not have significant difference between group; Each is organized the main organs histopathological examination and is not seen obviously unusual.The These parameters drug withdrawal is not seen change after 2 weeks yet.This test dosage is respectively 180,60,20 times of clinical medicine dose; According to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days does not have obvious influence to rat; No clear and definite toxicity target organ and sensitive indicator; The retardance toxic reaction is not seen in the convalescent period observation yet, points out the dosage safety property of Chinese medicine preparation clinical practice of the present invention higher.
3, select the SD rat for use; Give variable concentrations (18.0,6.0, the Chinese medicine preparation of the present invention of 2.0g crude drug/kg), irritate stomach every day once, continuous 90 days; Respectively organized 1/2 animal (male and female half and half) extremely that lives in 24 hours after the last administration, all the other 1/2 animals continuation observation, 2 all backs are extremely alive.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days with carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and check with indexs such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dose groups animal general state, all no abnormal variation of outward appearance sign, behavioral activity, food-intake and body weight gain; Three dose groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, do not have significant difference between group; Each is organized the main organs histopathological examination and is not seen obviously unusual.The These parameters drug withdrawal is not seen change after 2 weeks yet.This test dosage is respectively 180,60,20 times of clinical medicine dose; According to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days does not have obvious influence to rat; No clear and definite toxicity target organ and sensitive indicator; The retardance toxic reaction is not seen in the convalescent period observation yet, points out the dosage safety property of Chinese medicine preparation clinical practice of the present invention higher.
Pharmacodynamic experiment
One, the honey pill agent of Chinese medicine preparation of the present invention is to the small intestine movement of mice motional effects
1 test material
1.1 experimental animal: buy 50 of ICR mices by Institute of Radiation Medicine, Chinese Academy of Medical Sciences, male and female half and half, body weight 18～20g, animal credit number: SCXK Tianjin 2005-0001.
1.2 trial drug:
1.2.1 the honey pill agent of Chinese medicine preparation of the present invention.The honey pill agent of Chinese medicine preparation of the present invention is stayed with steaming that water is mixed with 0.467,0.233, the honey pill agent suspension of 0.117g crude drug/ml is for use.
1.2.2 (Xinxiang City, Henan Province Chang Le pharmaceutical factory H41020226), is diluted to 0.01mg/ml solution with normal saline before using to atropine sulfate injection.
1.2.3 active carbon; Arabic gum (process and contain 10% Radix Acaciae senegalis, the charcoal end distilled water suspension of 5% active carbon).
1.3 testing equipment: the T-500 electronic balance (the two outstanding test instrunment in Changshu factory, numbering: 256), PL203 precise electronic balance.
2 test methods
Select 18～20g body weight mice for use, be divided into 5 groups, be i.e. the high, medium and low dose groups of honey pill agent of blank group, positive drug (atropine) group, Chinese medicine preparation of the present invention by the method for body weight random stratified.Every group 10, male and female half and half.Blank group and atropine group are irritated stomach distilled water 30ml/kg, and high, medium and low dose groups is irritated honey pill agent suspension 14,7, the 3.5g crude drug/kg of stomach Chinese medicine preparation of the present invention, 1 time/d respectively.Irritate stomach after 7 days, can't help water 18h in the experiment the previous day of fasting at dusk, after the 8th day last administration 1h (atropine diluent 0.1mg/kg 5min), each group is only irritated stomach charcoal end suspension 0.2ml/.Put to death animal behind the 20min, open the abdominal cavity and separate mesentery, the clip front end is to pylorus, and the intestinal tube of rear end to ileocecus places on the pallet.Gently the small intestinal pendulum is in line, measures intestinal tube length as " small intestinal total length ".Distance conduct " prepared Chinese ink is in the propulsive distance of enteral " from pylorus to prepared Chinese ink forward position.Formula calculates prepared Chinese ink propelling rate: prepared Chinese ink propelling rate=(prepared Chinese ink is in enteral advance distance/small intestinal total length) * 100%.
3 result of the tests
Compare with matched group; Positive drug atropine group charcoal end forward position propelling rate obviously reduces (P＜0.05); The honey pill agent 3.5g crude drug of Chinese medicine preparation of the present invention/kg group has certain obviously minimizing effect of charcoal end forward position propelling rate that makes, but increases with dosage, and charcoal end forward position propelling rate is strengthened; And be relevant with dosage be higher than the trend of matched group, but not statistically significant.See table 1
The honey pill agent of table 1 Chinese medicine preparation of the present invention is to the mouse small intestine motional effects
| Group | The example number | Forward position propelling rate % |
| The normal control group | 10 | 64.78±9.36 |
| Model control group | 10 | 72.45±8.716 |
| The atropine group | 10 | 43.41±14.22 ** |
| Honey pill agent 3.5g crude drug/kg of the present invention | 10 | 57.45±16.91 |
| Honey pill agent 7g crude drug/kg of the present invention | 10 | 78.81±17.29 |
| Honey pill agent 14g crude drug/kg of the present invention | 10 | 82.39±15.32 |
Annotate: compare with the normal control group:
*P＜0.01.
4 conclusion (of pressure testing)s
Compare with the normal control group, the honey pill agent 3.5g crude drug/kg of Chinese medicine preparation of the present invention has certain inhibition small intestine movement of mice motion effect; 7-14g crude drug/kg gastric infusion has showed the propulsive trend in promotion small intestine movement of mice charcoal end with the dosage increase, but has not all had tangible statistical significance.
Two, the honey pill agent of Chinese medicine preparation of the present invention is to hyperkinesis mouse small intestine motional effects
1, neostigmine injection (Xinyi, Shanghai Jin Zhu pharmaceutcal corporation, Ltd produces, lot number 060204) is diluted to the 0.01mg/ml diluent with normal saline before using.
2, mice is divided into 5 groups by the method for body weight random stratified, i.e. the high, medium and low dose groups of honey pill agent of blank group, model group contrast, positive drug (atropine) group, Chinese medicine preparation of the present invention.Every group 10, male and female half and half.Blank group, model control group and atropine group are irritated stomach distilled water 30ml/kg, and high, medium and low dose groups is irritated honey pill agent suspension 14,7, the 3.5g crude drug/kg of stomach Chinese medicine preparation of the present invention, 1 time/d respectively.Irritate stomach after 7 days; Can't help water 18h in the experiment the previous day of fasting at dusk, behind the 8th day last administration 1h, except that the blank group; All the other respectively organize equal sc neostigmine solution 0.1mg/10ml/kg (atropine diluent 0.1mg/10ml/kg), and each group is only irritated stomach charcoal end suspension 0.2ml/ behind the 5min.Put to death animal behind the 20min, open the abdominal cavity and separate mesentery, clip small intestinal front end is to pylorus, and the intestinal tube of rear end to ileocecus places on the pallet.Gently the small intestinal pendulum is in line, measures intestinal tube length as " small intestinal total length ".Distance conduct " prepared Chinese ink is in the propulsive distance of enteral " from pylorus to prepared Chinese ink forward position.Use formula calculating prepared Chinese ink propelling rate to be: prepared Chinese ink propelling rate=(prepared Chinese ink is in enteral advance distance/small intestinal total length) * 100%
3, result of the test
Compare with the blank group, the model control group intestinal propulsion is obviously hyperfunction, explains that neostigmine causes mouse small intestine and advances hyperfunction model copy success.Compare with model control group, atropine group and low dose group can obviously suppress the charcoal end forward position propelling rate (p＜0.01 and p＜0.05 respectively) of the hyperfunction mice of intestine movement function; High dose group has the trend that promotes intestinal propulsion, but not statistically significant.See table 2.
The honey pill agent of table 2 Chinese medicine preparation of the present invention is to the hyperfunction mouse small intestine motional effects of intestinal propulsion
| Group | The example number | Forward position propelling rate % |
| The normal control group | 10 | 65.78±7.36 |
| Model control group | 10 | 71.45±5.716△ |
| The atropine group | 10 | 42.41±12.22 *** |
| Honey pill agent 3.5g crude drug/kg of the present invention | 10 | 65.45±14.91 ** |
| Honey pill agent 7g crude drug/kg of the present invention | 10 | 69.11±15.29 |
| Honey pill agent 14g crude drug/kg of the present invention | 10 | 84.39±12.32 |
Annotate: compare with the normal control group: △ P＜0.05, compare with model control group:
*P＜0.01,
* *P＜0.001.
Conclusion (of pressure testing): hyperfunction mouse small intestine motion has obvious inhibitory action to the honey pill agent 3.5g/kg of Chinese medicine preparation of the present invention to intestine movement function, increases with dosage, shows the trend that promotes the bowel movement effect.This test is to having studied the honey pill agent treatment enteritis of Chinese medicine preparation of the present invention, the pharmacological action mechanism of dysentery at aspects such as body and stripped function of intestinal canal influence, stopping leak, antibacterial, the anti-immunity of antiinflammatory; Result of the test shows; Though the honey pill agent of Chinese medicine preparation of the present invention is not to reach the stopping leak effect through direct inhibition intestinal propulsion; But it can promote intestinal digestion, absorb, and certain bacteriostasis is arranged, and shows the anti-immunization of stronger antiinflammatory.
Three, the honey pill agent of Chinese medicine preparation of the present invention is to xylose in the normal rat urine and diastatic influence
1 test material
1.1 experimental animal: buy 60 of wistar rats by Beijing Vital River Experimental Animals Technology Co., Ltd., male and female half and half, body weight 130～145g, animal credit number: SCXK (capital) 2007-0001.
1.2 trial drug:
1.2.1 the honey pill agent of Chinese medicine preparation of the present invention: every g medicated powder contains the 2g extract, with the honey pill agent of Chinese medicine preparation of the present invention with distilled water be mixed with 0.6,0.3, the suspension of 0.15g crude drug/ml is for use.
1.2.2 dioctahedral smectite (the general living Tianjin of rich good fortune benefit pharmaceutical Co. Ltd, lot number S0120), it is for use to be mixed with the 0.3g/ml suspension with distilled water.
1.2.3D-xylose (Tianjin recovery fine chemistry industry institute, lot number 20070712), it is for use to be mixed with the 10%D-xylose solution with distilled water.
1.2.4 starch enzyme reagent kit (building up bio-engineering research by Nanjing provides, lot number 20070525); D-xylose test kit (building up bio-engineering research by Nanjing provides, lot number 20070525).
1.3 testing equipment: T-1000 electronic balance (the two outstanding test instrunment in Changshu factory, numbering 3265); The rat metabolic cage; Ultraviolet spectrophotometer.
2 test methods
Rat is divided into 5 groups by the method for body weight stratified random, i.e. the high, medium and low dose groups of honey pill agent of blank group, positive drug group, Chinese medicine preparation of the present invention.Every group 10, male and female half and half.High, medium and low dose groups is irritated the honey pill agent suspension 6,3 of stomach Chinese medicine preparation of the present invention, the suspension 10ml/kg that 1.5g crude drug/kg irritates the stomach corresponding dosage respectively, and the positive drug group is irritated clothes consubstantiality salification acid dioctahedral smectite solution, and the blank group is irritated stomach distilled water, 1 time/d.Behind the successive administration 2d, can't help water 18h in the experiment the previous day of fasting at dusk, behind the commentaries on classics day last administration 1h, the massage rat abdomen is with emptying intravesical storage urine, and every rats gavaged 10%D-xylose solution 5mL puts into metabolic cage, collection 5h urine.Measure xylose and amylase content in the urine.
3 result of the tests
The honey pill agent 6g/kg group amylase in urine of Chinese medicine preparation of the present invention active and D-xylose excretion and matched group ratio, more obviously rising, data are seen table 3.
The honey pill agent of table 3 Chinese medicine preparation of the present invention is to the influence of normal rat xylose and amylase content
| Group | The example number | 5h urinates xylose content (g) | Amylase content |
| The normal control group | 10 | 8.52±1.65 | 3896.78±2132.36 |
| Smecta group | 10 | 13.72±4.96 ** | 3234.78±1317.64 |
| Honey pill agent 1.5g crude drug/kg of the present invention | 10 | 11.02±4.87 | 3576.13±1532.76 |
| Honey pill agent 3g crude drug/kg of the present invention | 10 | 10.42±3.92 | 4496.78±1798.96 |
| Honey pill agent 6g crude drug/kg of the present invention | 10 | 12.72±2.76 * | 7893.78±2612.37 *** |
Annotate: compare with matched group:
*P＜0.05,
*P＜0.01,
* *P＜0.001.
4 conclusion (of pressure testing)s:
Amylase activity is measured and xylose absorption test is the reflection intestinal digestion of generally acknowledging, the index of absorption function.Amylase is a kind of important digestive enzymes of human consumption process, and hyposecretion can influence food digestion, and this experimental result shows that the honey pill agent of Chinese medicine preparation of the present invention can strengthen amylase activity, helps the raising of human consumption function.Mainly absorb through the facilitation diffusion after the D-xylose is for oral administration by duodenum and jejunum; Because of it is a monosaccharide; In advance digestion before absorption, the necessity of decomposing, after the absorption also not by liver and the metabolism of surrounding tissue institute, its water solublity in addition; Can most of from urine, discharge, predict the absorption function of small intestinal so can make an excuse behind the quantitative xylose of clothes from urinate output with prototype.This experimental result shows that the honey pill agent of Chinese medicine preparation of the present invention can improve the intestinal digestion absorption function.
Four, the honey pill agent of Chinese medicine preparation of the present invention influences the mice with spleen deficiency diarrheal
1 test material
1.1 experimental animal: buy 72 of ICR mices by Institute of Radiation Medicine, Chinese Academy of Medical Sciences, male and female half and half, body weight 18～20g, animal credit number: SCXK Tianjin 2005-0001.
1.2 trial drug
1.2.1 the honey pill agent of Chinese medicine preparation of the present invention: every g medicated powder contains 2g
Extract, with the honey pill agent of Chinese medicine preparation of the present invention with distilled water be mixed with 0.467,0.233, the honey pill agent suspension of the Chinese medicine preparation of the present invention of 0.117g crude drug/ml is for use.
1.2.2 berberine water (berberine hydrochloride) notes removing sugar-coat, the accurate title, decide, porphyrize, and precision takes by weighing in right amount (being equivalent to berberine hydrochloride 0.3g approximately), puts in the beaker, and it is for use that adding distil water is mixed with 10% aqueous suspension.
1.2.3 XIANGSHA LIUJU WAN (happy core hall pharmaceutical factory of new Pharmaceutical Group Co.,Ltd produces in the Tianjin, lot number A118008).
1.3 testing equipment: the T-500 electronic balance (the two outstanding test instrunment in Changshu factory, numbering: 256), PL203 precise electronic balance (Mettler-Toledo Instrument's manufacturing).
2 test methods
Mice is divided into 6 groups by the method for body weight stratified random, i.e. the high, medium and low dose groups of honey pill agent of blank group, model control group, positive drug group, Chinese medicine preparation of the present invention, 12 every group.After the animal random packet, except that the blank group, all the other are respectively organized and only irritate clothes 10% berberine aqueous suspension 0.5ml/ every day, and loss of appetite appears in animal behind the administration 7d, activity reduces, has loose bowels, erects insufficiency of the spleen symptoms such as hair hogback, hair color tarnishing.Only continue to irritate clothes berberine aqueous suspension 0.5ml/ back every day; The honey pill agent group of Chinese medicine preparation of the present invention is irritated honey pill agent suspension 14,7, the 3.5g crude drug/kg of stomach Chinese medicine preparation of the present invention respectively behind the 1h; The administration volume is 30ml/kg, and blank group and model group are irritated clothes with the volume distilled water.According to said method behind the administration 3d, water is can't help in each treated animal fasting at dusk.Change a day morning and play the same method administration, behind the administration 1h, irritate stomach berberine aqueous suspension 0.5ml/ only (the blank group gives with the volume distilled water).Each mice places respectively in the mouse cage that is lined with clean filter paper, and 1h changes packing paper once, observes and record 6h muck grain number, and adds up through the SPSS11.5 statistical software.
3 result of the tests
In the defecation 4h, model group loose stool grain number is explained the model of spleen deficiency success than matched group showed increased, and three dose groups mucks of honey pill agent grain number average of Chinese medicine preparation of the present invention is higher than model group, does not show anti-diarrhea effect.And between defecation the 4th～6h, three dose groups of the honey pill agent of Chinese medicine preparation of the present invention and model control group compare, and muck grain number obviously reduces (P＜0.05).Data are seen table 4～5.
The honey pill agent of table 4 Chinese medicine preparation of the present invention is to the influence of diarrhea due to hypofunction of the spleen mice loose stool grain number
Annotate: compare with the normal control group: △ P＜0.05, △ △ △ P＜0.001, compare with model group:
*P＜0.05.
The honey pill agent of table 5 Chinese medicine preparation of the present invention is to the influence of diarrhea due to hypofunction of the spleen mice loose stool grain number
Annotate: compare with the normal control group: △ P＜0.05, △ △ △ P＜0.001.Compare with model group:
*P＜0.05.
4 conclusion (of pressure testing)s: the honey pill agent of Chinese medicine preparation of the present invention does not show simple stopping leak effect at the initial stage of having loose bowels; Promote muck to discharge on the contrary; But dehumidifying excrement paresthesia alleviateding time shifts to an earlier date than model group after taking the honey pill agent of Chinese medicine preparation of the present invention, thereby reaches the stopping leak effect.
Specific embodiment:
Embodiment 1: Gong, man, 39 years old.Examine and tell stomachache, have loose bowels, show effect repeatedly about 5 years, many because of suffering from cold or diet raw food increases the weight of, once repeatedly quiet, oral antibiotic do not see be clearly better (specifically medicining condition is not quite clear), inscribe disease and see left lower quadrant dull pain; Big loose stool is thin, is with white mucus, and idol has stool band blood, and every day 3～5 times, then let out dawn; Normal companion's soreness of waist, abdominal distention, borborygmus, poor appetite, spiritlessness and weakness; Dim complexion, a little less than the shape body slimming, light red tongue is dim red, and tongue is white, the deep-thready pulse string.Sigmoidoscopy: a large amount of mucus in intestinal 20～25cm place, 21cm sees at the place syringe needle massive hemorrhage point, the obvious congestion and edema of mucosa on every side.18cm sees at the place Semen Sesami massive hemorrhage point.18cm～20cm place mucous hyperemia swelling is piebald shape and changes mucus smear no abnormality seen.Stool is cultivated no bacterial growth.In order to descend Drug therapy: Radix Pulsatillae 10g, Rhizoma Dioscoreae 10g, Semen Euryales (parched) 15g, Herba Portulacae 5g, Saussurea lappa Clarke 10g; Semen Myristicae 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Herba Violae 10g, Bulbus Allii Macrostemonis 10g; Pericarpium Arecae 10g, Rhizoma Coptidis 5g, Pericarpium Citri Reticulatae 10g, Cortex Cinnamomi 10g, Semen Cuscutae 10g; Fructus Schisandrae Chinensis 10g, Radix Rehmanniae Preparata 10g, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10g, Endothelium Corneum Gigeriae Galli 10g.
Take with Chinese medicine decoction, serve on two onsets course of treatment, stomachache is ended, and has blood in stool and ends, and beginning appetite is normal, serve on recovery from illness in three months, follows up a case by regular visits to and does not have recurrence.
Embodiment 2: square Chen, man, 28 years old.Symptom: afternoon borborygmus rumbling January, preceding throwing linggui zhugan decoction is just effective, but drug withdrawal rises again, and stool matter is mashed, every day 1～2 time, liver pain, belch, red tongue, yellow and thin fur, thready and stringy pulse.Dialectical: the borborygmus stool is mashed, and the subduing the hyperfunction of the liver with strong taste is made liver spleen (stomach) relation in order.In order to descend Drug therapy: Radix Pulsatillae 10g, Rhizoma Dioscoreae 10g, Semen Euryales (parched) 15g, Herba Portulacae 5g, Saussurea lappa Clarke 10g, Semen Myristicae 10g; Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Herba Violae 10g, Bulbus Allii Macrostemonis 10g, Pericarpium Arecae 10g, Rhizoma Coptidis 5g; Pericarpium Citri Reticulatae 10g, Fructus Aurantii 10g, Radix Paeoniae Alba 10g, Cortex Magnoliae Officinalis 10g, Radix Puerariae 10g, windproof 10g.Pay a return visit: the back borborygmus of taking medicine disappear, and surplus disease all subtracts.
Embodiment 3: the Qin, woman, 29 years old.Symptom: umbilicus week stomachache is then desired to defecate, alleviation of pain after an action of the bowels, every day person three like this, it is shapeless defecate, folder sticks and freezes and indigestion food, borborygmus are indigestion and loss of appetite, light red tongue, yellow, greasy and thin fur, thready and stringy pulse.Dialectical: change the drink between intestinal, patient's times of defecation is originally many, need not so abandon Radix Et Rhizoma Rhei; Invigorating the spleen for eliminating dampness, because of drink by humidogene, so with the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae invigorating the spleen for eliminating dampness drink to shut out gradually; The stomach function regulating that helps digestion,, stool indigestion and loss of appetite because of the patient contains indigestion food, so help digestion with Massa Medicata Fermentata, Fructus Hordei Germinatus, Fructus Crataegi (parched to brown); Relieving spasm to stop pain, Qinghua is damp and hot.In order to descend Drug therapy: Radix Pulsatillae 10g, Rhizoma Dioscoreae 10g, Semen Euryales (parched) 15g, Herba Portulacae 5g, Saussurea lappa Clarke 10g, Semen Myristicae 10g; Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Herba Violae 10g, Bulbus Allii Macrostemonis 10g, Pericarpium Arecae 10g; Rhizoma Coptidis 5g, Pericarpium Citri Reticulatae 10g, each 10g of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Endothelium Corneum Gigeriae Galli 10g serve on two courses of treatment.Pay a return visit: take medicine after the 3rd dose, defecate 1 time on the 1st, be shaped, mucus reduces, and digest does not have and suffers from abdominal pain invariably, and no borborygmus are given 7 doses again as a means of consolidation.
Embodiment 4 Chens, the man, 45 years old, because of abdominal discomfort, borborygmus were suffered from diarrhoea and are admitted to hospital day surplus in the of 20, because of foam in the urine increases, albumen are arranged in the urine, look into blood creatinine (SCR) in local hospital: 179 μ mol/l, blood urea nitrogen (BUN): 8.3mmol/l.B ultrasonic shows that right kidney dwindles, in calculus is arranged, skin medullary substance boundary is unclear, the cortex attenuation, echo strengthens, check urine protein in back adds for half always or is negative.The edema history is denied history of hypertension when denying the children, denies hepatitis, typhoid fever, and the tuberculosis medical history is denied familial nephropathy medical history, no penicillin anaphylaxis history.Before more than 20 day, abdominal discomfort occurs after taking traditional Chinese medicine, feel sick, borborygmus are promptly suffered from diarrhoea, and are yellow loose stool every day 25 times, do not have sticking freeze bloody purulent stool, no jaundice melena, no tenesmus.Right kidney percussion pain is suspicious when being admitted to hospital, and the left side is negative, and it is soft to reach matter under the right rib of liver, does not reach under the spleen rib.Intestinal mirror: chronic colitis.Diagnosis: interstitial nephritis, chronic colitis.In order to descend Drug therapy: Radix Pulsatillae 10g, Rhizoma Dioscoreae 10g, Semen Euryales (parched) 15g, Herba Portulacae 5g, Saussurea lappa Clarke 10g, Semen Myristicae 10g; Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Herba Violae 10g, Bulbus Allii Macrostemonis 10g, Pericarpium Arecae 10g, Rhizoma Coptidis 5g; Pericarpium Citri Reticulatae 10g, Cortex Cinnamomi 10g, Semen Cuscutae 10g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae Preparata 10g, Endothelium Corneum Gigeriae Galli 10g.Treatment: the Chinese medicine decoction, took continuously 3 months.Colitis is given anti symptom treatment.Check after March, right kidney percussion pain is negative, lather collapse in the urine.
Chinese medicine preparation of the present invention has suppressing the hyperactive liver pain relieving, regulating qi-flowing for strengthening spleen, spleen reinforcing lung kidney, invigorating the spleen and replenishing QI and yang invigorating antidiarrheal effect; Treating acute and chronic enteritis and colitis, are rushed down back pain and are relaxed diseases such as outbreak repeatedly at the borborygmus diarrhoea that liver-yang hyperactivity and weakness of the spleen and stomach cause, anorexia and loose stool, lassitude of the limbs and weakness.And prescription is simple, and is cheap for manufacturing cost, can promote the use of.
Claims (8)
1. a treatment borborygmus diarrheal Chinese medicine preparation is characterized in that the ratio of weight and number of various components is: 10～20 parts of the Radix Pulsatillaes, 10～20 parts of Rhizoma Dioscoreaes; 10～20 parts of Semen Euryales (parched), 10～15 parts of Herba Portulacaes, 10～20 parts of Saussurea lappa Clarke, 10～20 parts of Semen Myristicaes; 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts in Poria, 10～20 parts of Herba Violaes, 10～20 parts of Bulbus Allii Macrostemonis; 10～20 parts of Pericarpium Arecae, 10～15 parts of Rhizoma Coptidis, 10～20 parts of Pericarpium Citri Reticulataes.
2. according to the said treatment borborygmus of claim 1 diarrheal Chinese medicine preparation, it is characterized in that, further comprise the following component of ratio of weight and number: 10～20 parts of Cortex Cinnamomis, 10～20 parts of Semen Cuscutae, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts in Radix Rehmanniae Preparata.
3. according to the said treatment borborygmus of claim 1 diarrheal Chinese medicine preparation, it is characterized in that, further comprise the following component of ratio of weight and number: 10～20 parts of Cortex Magnoliae Officinalis, 10～20 parts of Fructus Aurantiis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Puerariaes, windproof 10～20 parts.
4. according to the said treatment borborygmus of claim 1 diarrheal Chinese medicine preparation, it is characterized in that, further comprise the following component of ratio of weight and number: each 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 10～15 parts of Endothelium Corneum Gigeriae Galli.
5. the method for preparing like each said treatment borborygmus diarrheal Chinese medicine preparation in the claim 1～4 is characterized in that the dosage form of said Chinese medicine preparation is a capsule, and method for preparing may further comprise the steps:
A. said component adds water extraction 2 times, makes extract become the extractum shape, is component one;
B. the medicinal residues after abovementioned steps is extracted add the ethanol thickening filtration and become the extractum shape, are component two;
C becomes dried cream with above-mentioned two kinds of extractum concentrate dryings, mixes and pulverizes, and it is an amount of to add starch, mixing, fill capsule.
6. according to the method for preparing of the said treatment borborygmus of claim 5 diarrheal Chinese medicine preparation, it is characterized in that among the said step a, the water logging bubble that said its weight portion of component adding 5-10 doubly measures 1-2 hour extracts 2 times; Solution 1-2 after the heating extraction hour, be concentrated into the extractum shape, become component one.
7. according to the method for preparing of the said treatment borborygmus of claim 5 diarrheal Chinese medicine preparation, it is characterized in that among the said step b, the medicinal residues after abovementioned steps is extracted added the 60-90% soak with ethanol 0.5-1.5 hour; Extract twice, each 1-2 hour, merge extractive liquid, filtered for the first time; Concentrate, the 80-160 order filters for the second time, gets supernatant after centrifugal for 6000-10000 rev/min; Through the molecular weight that dams is the ultrafiltration post ultrafiltration of 5000-10000, and relative density was 1.35 extractum when ultrafiltrate was evaporated to 80 ℃, heating and refluxing extraction 2 times; Each 30 minutes～45 minutes, 2 extracting solution merging are settled into the extractum shape, as component two.
8. method for preparing like each said treatment borborygmus diarrheal Chinese medicine preparation in the claim 1～4; It is characterized in that; Said Chinese medicine preparation dosage form is a honey pill agent, and its preparation method comprises: said component was soaked 30 minutes to 1 hour heated and boiled 30～40 minutes; Filter filtrate for later use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the third time, filters; Three filtratings are lumped together, and heating is concentrated into pasty state, puts into 70 ℃～80 ℃ oven dry of baking oven postcooling, dries postcooling, and mixing with Mel is twisted into slice; With 5g is ball wax seal packing.
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| CN102198261B (en) * | 2011-05-27 | 2012-08-22 | 孔建 | Chinese medicinal preparation for treating elder chronic colitis and preparation method thereof |
| CN102406887B (en) * | 2011-12-02 | 2013-10-30 | 赵明芳 | Traditional Chinese medicine composition for treating chronic diarrhea and preparation method thereof |
| CN102698145B (en) * | 2012-06-19 | 2013-07-24 | 大连民族学院 | Chinese medicine preparation for tonifying spleen and stopping diarrhea |
| CN102772781B (en) * | 2012-08-21 | 2014-09-10 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof |
| CN103223083A (en) * | 2013-03-27 | 2013-07-31 | 张宗升 | Extract product of traditional Chinese medicine |
| CN103585506B (en) * | 2013-11-05 | 2016-04-06 | 卢继英 | A kind of Chinese medicinal enema for the treatment of infantile autumn diarrhea |
| CN104383291A (en) * | 2014-10-28 | 2015-03-04 | 王慧 | Vital energy regulating and blood conditioning preparation for treating diarrhea and preparation method thereof |
| CN104623383A (en) * | 2015-03-05 | 2015-05-20 | 于巧媛 | Traditional Chinese medicine for treating damp-heat type scouring disease |
| CN105561129A (en) * | 2016-01-04 | 2016-05-11 | 四川双鑫生物科技有限公司 | Oral drug for treating children diarrhea and preparation method thereof |
| CN105561111A (en) * | 2016-03-18 | 2016-05-11 | 张传涛 | Traditional Chinese medicine composition for treating functional diarrhea |
| CN114377071A (en) * | 2022-01-06 | 2022-04-22 | 宋易昕 | Traditional Chinese medicine enema and preparation method thereof |
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| CN101361944A (en) * | 2008-09-28 | 2009-02-11 | 韩瑞芹 | Traditional Chinese medicine combination for treating wean diarrhea |
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