CN105435190A - Traditional Chinese medicine composition for treating cold-heat jumble asthma and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating cold-heat jumble asthma and preparation method of traditional Chinese medicine composition Download PDF

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CN105435190A
CN105435190A CN201511010026.5A CN201511010026A CN105435190A CN 105435190 A CN105435190 A CN 105435190A CN 201511010026 A CN201511010026 A CN 201511010026A CN 105435190 A CN105435190 A CN 105435190A
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chinese medicine
medicine composition
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rhizoma
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陆学超
臧建华
范传波
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Abstract

The invention discloses a traditional Chinese medicine composition for treating cold-heat jumble asthma and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw herbal materials: ephedra, pardanthus, processed rhizoma pinelliae, fried rhizoma atractylodis macrocephalae, poria cocos, citrus red, cicada ecdysis, lumbricus, radix peucedani, dark plum, asarum, rhizoma zingiberis, pyrrosia lingua, Chinese angelica, pericarpium zanthoxyli, cassia twig, radix codonopsitis, fructus cannabis, aster, common coltsfoot flower, shizandra berry, radix scutellariae, white mustard seed, rhizoma corydalis and long pepper. The traditional Chinese medicine composition has the benefits that the Chinese herbal medicines with different properties are adopted, and are scientific in compatibility, so that the traditional Chinese medicine composition can realize the effects of warming and heat clearing simultaneously and phlegm dissipating to remove asthma, can realize an ideal curative effect on cold-heat jumble asthma, and is safe, free of toxic and side effects, capable of treating both symptoms and root causes, safe and effective; through the adoption of the traditional Chinese medicine composition, the treatment cost is relatively low, and through the combination of oral taking and external application, the effects of warming and heat clearing simultaneously and phlegm dissipating to remove asthma can be realized better, and the curative effect is obvious.

Description

Be used for the treatment of Chinese medicine composition of intermingling cold and heat bronchial wheezing and preparation method thereof
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, being particularly a kind ofly used for the treatment of Chinese medicine composition of intermingling cold and heat bronchial wheezing and preparation method thereof.
Background technology
Bronchial asthma is common clinical and frequently-occurring disease, sickness rate is 1% ~ 3%, any age can be betided, great majority onset before 12 years old, male is more than women (about 2 ~ 3:1), child is more than adult, and when being apt to occur in autumn and winter season and climate change, cold district is more than warm area.Over nearly more than 10 years, the national asthma prevalence such as the U.S., Britain, Australia, New Zealand are on the rise, and about there are 1.5 hundred million asthmatic patients in the whole world, and the patient dying from asthma every year reaches 180,000.The prevalence of China's asthma is about 1%, child Ke Da 3%, estimates at more than 1,000 ten thousand patients, and asthma has become the public health disease a kind of occurred frequently of serious threat health of people.Bronchial asthma is equivalent to " bronchial wheezing " category of the traditional Chinese medical science.Bronchial wheezing is a kind of lung system illness of common recurrent exerbation.It lies prostrate lung by retained phlegm, and multiple because of factors such as exopathogen, diet, feelings will, overstrains, cause stagnation of QI causing phlegm retention, air flue contraction is anxious, narrow and fall ill.With ictal whistling sound in the throat, dyspnea, very then failing to lie flat due to dyspnea is main manifestations.First " Experience on Acupuncture and Moxibustion Therapy " that king Song by name of asthma is fair and unbiased to show at it propose in book, as he says: " because of with rule asthma by men, Miao (thorn) fei shu; not his cave of Miao ", " all have breathe heavily and heavy breathing person; for invariably aching by fei shu, being all Miao and stinging fei shu, make moxibustion and heal ".To Jin and Yuan dynasty, ZHU Dan-xi begins in book to become a section using asthma as independently name of disease at " danxi's experiential therapy ", and has done concrete discussion to its method for the treatment of, principle of medication etc., and from then on the name of disease of asthma just formally produces period." dyspnea with rapid and short breath of Jing Yue's complete work assorted card plan " cloud: " breathe heavily and have long-standing, namely meeting trembles with fear sends out, or namely chance labor sent out, also name asthma.Based on righting gas when not sending out, to attack pathogen when both sending out, righting gas person must distinguish negative and positive, its moon of cloudy nourishing for deficiency, its sun of positive nourishing for deficiency.Attack pathogen person, must be point very micro-, or its wind loose, or Wen Qihan, or its phlegm-fire clearly, send out of a specified duration person, gas is invariably empty, therefore should drink in dissipating and add temperature compensation, or should measure in temperature compensation and add dissipation." Chinese medicine thinks that asthma is because of latent phlegm retaining in the lung, and relevant with factors such as heredity, body constitution, environment, diseases caused by exogenous pathogenic factor, diet, overstrains.The cause of disease of asthma is with the deficiency of the lung, insufficiency of the spleen, kidney asthenia as the principal aspect, and be mark with wind, cold, heat, wet, expectorant, the stasis of blood, stage of attack shows as master with excess syndrome, and the catabasis is in the majority with deficiency syndrome performance.Asthmatic patient have volt in retained phlegm, mostly is lung, spleen, the dirty yang-energy of kidney three are deficient.The spleen has the function to transport and transform nutrients, if insufficiency of the spleen transformation failure of spleen, then the turbid interior life of expectorant, above stores in lung; Kidney is the root of human body, main improving inspiration by invigorating kidney-QI, if deficiency of the kidney, then takes the photograph to receive and haves no right, to activate then tachypnea, dyspnea; Lung governing qi and take charge of breathing, if insufficiency of lung-QI, then space between skin and muscles is solid, and exopathogen can be entered by mouth and nose, and six climate exopathogens visitor brings out abnormal rising of lung-QI in flesh table, and it is unfavorable to breathe, phlegm rising following QI, obstruction of QI due to retention of phlegm, mutually fights with, and be jammed air flue, and lung qi a surname falls not normal, causes rale tachypnea.The Chinese traditional treatment of asthma is rich and varied, except internal treatment, still has all multi-methods such as the external application of Chinese medicine, acupoint therapy.Chinese medicine asthma, lessly there is side effect in determined curative effect, generally acknowledge by medical circle.Some effective method for the treatment of and prescription, confirm by modern science and technology.So traditional Chinese medical science Chinese medicine asthma has wide prospect.The treatment of asthma should take stopgap measures with stage of attack, and the catabasis effects a permanent cure as principle, carries out according to different clinical manifestations and different phase.Stage of attack, should first divide asthma of cold-type, asthma of heat type, coldheat complex, gives eliminating evil sending down the abnormal ascending QI, expectorant Dingchuan, cold and heat be adjusted to master; Catabasis should being focused on tonifying the lung, strengthening the spleen, being reinforced the kidney as controlling, in case recurrence.Especially when facing card, coldheat complex pattern of syndrome is more common, and the performance of its syndrome mostly is wind and cold and violates lung, or cold-phlegm volt lung, then heat transformed from stagnated cold for a long time, so that coldheat complex.Heat transformed from stagnated cold, so that retention of phlegm-heat in the interior, impairment of dispersing and descending function of the lung is then coughed, cough up yellow sputum or white thick expectorant, and gluing difficulty is coughed up.The exterior attacked by wind and cold, failing shows to fall apart in time then sees aversion to wind fear of cold, and back is cold.Evil lung of violating is defended, the unfavorable then sneeze of key, rhinocnesmus outside lung.Xerostomia is for drink, and red tongue, yellow fur is hot and suffocating resembling, and Therapeutic Principle mostly is that cold and heat are double to be executed, and resolving phlegm and relieving asthma is method.
The medicine of western medical treatment asthma can be divided into control medicine and cushion.(1) medicine is controlled: refer to the medicine needing use long-term every day.These medicines make asthma maintain clinic control mainly through antiinflammatory action, comprising inhaled (abbreviation hormone) whole body hormone, leukotrienes regulator, long acting β_2 agonistics (LABA, must with powder for inhalation use in conjunction), sustained-release theophyline, sodium chromoglicate, anti-IgE antibodies and other contribute to the medicine etc. reducing systemic hormone dosage; (2) cushion: refer to the medicine used as required.These medicines remove bronchospasm thus relieving asthma symptoms, comprising quick-acting suction broxaterol, whole body hormone, imbedibility anticholinergic agents, fugitive theophylline and fugitive oral broxaterol etc. by rapid.Said medicine especially controls medicine and needs long-term taking, and long-time use can be developed immunity to drugs.
Summary of the invention
Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, toxic and side effects is little and drug effect is significantly used for the treatment of Chinese medicine composition of intermingling cold and heat bronchial wheezing and preparation method thereof.
In order to realize foregoing invention object, the invention provides a kind of Chinese medicine composition being used for the treatment of intermingling cold and heat bronchial wheezing, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: 10 ~ 20 parts, Herba Ephedrae, Rhizoma Belamcandae 10 ~ 20 parts, Rhizoma Pinelliae Preparata 10 ~ 20 parts, Rhizoma Atractylodis Macrocephalae preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Exocarpium Citri Rubrum 10 ~ 25 parts, Periostracum Cicadae 10 ~ 18 parts, Pheretima 10 ~ 17 parts, Radix Peucedani 10 ~ 20 parts, Fructus Mume 10 ~ 20 parts, Herba Asari 5 ~ 15 parts, Rhizoma Zingiberis 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, another name for Sichuan Province green pepper 10 ~ 16 parts, Ramulus Cinnamomi 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Fructus Cannabis 10 ~ 20 parts, Radix Asteris 10 ~ 21 parts, Flos Farfarae 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 16 parts, Radix Scutellariae 10 ~ 20 parts, Semen Sinapis Albae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts and Fructus Piperis Longi 10 ~ 20 parts.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: 12 ~ 18 parts, Herba Ephedrae, Rhizoma Belamcandae 14 ~ 18 parts, Rhizoma Pinelliae Preparata 12 ~ 18 parts, Rhizoma Atractylodis Macrocephalae preparata 14 ~ 18 parts, 12 ~ 19 parts, Poria, Exocarpium Citri Rubrum 14 ~ 21 parts, Periostracum Cicadae 13 ~ 15 parts, Pheretima 13 ~ 15 parts, Radix Peucedani 14 ~ 18 parts, Fructus Mume 12 ~ 19 parts, Herba Asari 5 ~ 12 parts, Rhizoma Zingiberis 12 ~ 18 parts, Folium Pyrrosiae 12 ~ 14 parts, Radix Angelicae Sinensis 14 ~ 18 parts, another name for Sichuan Province green pepper 14 ~ 15 parts, Ramulus Cinnamomi 14 ~ 18 parts, Radix Codonopsis 14 ~ 17 parts, Fructus Cannabis 14 ~ 18 parts, Radix Asteris 14 ~ 20 parts, Flos Farfarae 14 ~ 19 parts, Fructus Schisandrae Chinensis 12 ~ 15 parts, Radix Scutellariae 14 ~ 18 parts, Semen Sinapis Albae 14 ~ 18 parts, Rhizoma Corydalis 14 ~ 19 parts and Fructus Piperis Longi 13 ~ 16 parts.
Described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: 12 parts, Herba Ephedrae, Rhizoma Belamcandae 18 parts, Rhizoma Pinelliae Preparata 12 parts, Rhizoma Atractylodis Macrocephalae preparata 14 parts, 19 parts, Poria, Exocarpium Citri Rubrum 14 parts, Periostracum Cicadae 13 parts, Pheretima 15 parts, Radix Peucedani 14 parts, Fructus Mume 12 parts, Herba Asari 5 parts, Rhizoma Zingiberis 12 parts, Folium Pyrrosiae 12 parts, Radix Angelicae Sinensis 18 parts, another name for Sichuan Province green pepper 14 parts, Ramulus Cinnamomi 18 parts, Radix Codonopsis 14 parts, Fructus Cannabis 18 parts, Radix Asteris 14 parts, Flos Farfarae 14 parts, Fructus Schisandrae Chinensis 12 parts, Radix Scutellariae 16 parts, Semen Sinapis Albae 14 parts, Rhizoma Corydalis 18 parts and Fructus Piperis Longi 16 parts.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:
A, take said medicine according to ratio of weight and number, add the water soaking 1-2 hour of 5-10 times amount, extract the volatile oil of 2-5 hour, collect volatile oil, medicinal liquid filters, and medicinal residues are for subsequent use;
B, the medicinal residues that step a is obtained and remain other crude drug mixing mixture, adding alcoholic degree is 60-90% ethanol, soaks 1 hour, extract 3 times, each 2 hours, add the ethanol of 10 times of mixture qualities for the first time, second time adds the ethanol of 10 times of mixture qualities, merge extractive liquid, filters; Above-mentioned twice filtrate is merged and filters again, by 1.10-1.50 when to filter filtrate reduced in volume to the relative density obtained again be 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol 60-90%, 1.10-1.50 when to get supernatant concentration to relative density be 80 DEG C, obtains extractum;
C, get the extractum that step b obtains, add volatile oil and vegetable oil, mixing, grinds 10 minutes with colloid mill, constantly stirs, be chilled to room temperature and obtain Chinese medicine composition, incapsulate in housing by described Chinese medicine composition, obtain capsule finished product.
In described step a, that extracts volatile oil contained by said medicine is extracted as steam distillation or supercritical fluid extraction.
In described step b, extract and adopt membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
In order to better realize foregoing invention object, invention further provides a kind of preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, the dosage form of described Chinese medicine composition is patch, and described preparation method comprises the following steps:
A, take all raw medicinal materials by described ratio of weight and number, add in the 60-90% ethanol of 10 times amount, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extracting solution extracted twice obtained merges and obtains extracting solution one, and left standstill by extracting solution one, medicinal residues are for subsequent use;
B, by the medicinal residues in step a, the heating and refluxing extraction that adds water 1 time, each 1 ~ 2 hour, extracts to obtain extracting solution two, leaves standstill;
Extracting solution two merging that c, the extracting solution one obtained by step a and step b obtain, concentrated, obtain drug extract, the concentrated modulation of heating, obtains patch.
In described step c, extracting solution two merging that the extracting solution one obtained by step a and step b obtain, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into the relative density when temperature is 65 DEG C is 1.20 extractum; Namely patch is obtained after being in harmonious proportion with wine, vinegar, Mel.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, the dosage form of described Chinese medicine composition is tablet, described preparation method comprises the following steps: first all raw medicinal materials are put into 10 times amount 70-85% ethanol, heating and refluxing extraction 2 times, each 45 minutes, extract active ingredient, merged by 2 extracting solution and leave standstill, obtain extracting solution one, medicinal residues are for subsequent use; Medicinal residues are added 10 times of water gagings, heating and refluxing extraction 3 times, each 1 hour, 3 extracting solution are merged, obtains extracting solution two; Merge extractive liquid, one and extracting solution two, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when filtrate relative density is about 20 DEG C 1.06; Be the macroporous adsorptive resins eluting twice of 10L through volume by filtrate, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain raw material medicinal liquid; Add starch and be pressed into tablet.
Described Chinese medicine composition endo-medicine dosage form is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup; External drug dosage forms is: fumigant, ointment, liniment, tincture, ointment, powder, patch, gel or spray.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention adopts the Chinese crude drug of different properties, scientific compatibility, can play that cold temperature is double executes the effect with resolving phlegm and relieving asthma, desirable therapeutic effect can be reached to intermingling cold and heat bronchial wheezing, and safety, without any side effects, treating both the principal and secondary aspects of a disease, safety, effectively, medical expense is lower, and Orally taken and externally share and better can reach that cold temperature is doublely executed, the effect of resolving phlegm and relieving asthma, and therapeutic effect is remarkable.
Detailed description of the invention
Chinese medicine thinks that asthma is because of latent phlegm retaining in the lung, and relevant with factors such as heredity, body constitution, environment, diseases caused by exogenous pathogenic factor, diet, overstrains.The cause of disease of asthma is with the deficiency of the lung, insufficiency of the spleen, kidney asthenia as the principal aspect, and be mark with wind, cold, heat, wet, expectorant, the stasis of blood, stage of attack shows as master with excess syndrome, and the catabasis is in the majority with deficiency syndrome performance.Asthmatic patient have volt in retained phlegm, mostly is lung, spleen, the dirty yang-energy of kidney three are deficient.The spleen has the function to transport and transform nutrients, if insufficiency of the spleen transformation failure of spleen, then the turbid interior life of expectorant, above stores in lung; Kidney is the root of human body, main improving inspiration by invigorating kidney-QI, if deficiency of the kidney, then takes the photograph to receive and haves no right, to activate then tachypnea, dyspnea; Lung governing qi and take charge of breathing, if insufficiency of lung-QI, then space between skin and muscles is solid, and exopathogen can be entered by mouth and nose, and six climate exopathogens visitor brings out abnormal rising of lung-QI in flesh table, and it is unfavorable to breathe, phlegm rising following QI, obstruction of QI due to retention of phlegm, mutually fights with, and be jammed air flue, and lung qi a surname falls not normal, causes rale tachypnea.The Chinese traditional treatment of asthma is rich and varied, except internal treatment, still has all multi-methods such as the external application of Chinese medicine, acupoint therapy.Chinese medicine asthma, lessly there is side effect in determined curative effect, generally acknowledge by medical circle.Some effective method for the treatment of and prescription, confirm by modern science and technology.So traditional Chinese medical science Chinese medicine asthma has wide prospect.The treatment of asthma should take stopgap measures with stage of attack, and the catabasis effects a permanent cure as principle, carries out according to different clinical manifestations and different phase.Stage of attack, should first divide asthma of cold-type, asthma of heat type, gives eliminating evil sending down the abnormal ascending QI, and expectorant Dingchuan is main; Catabasis should being focused on tonifying the lung, strengthening the spleen, being reinforced the kidney as controlling, in case recurrence.
External therapy of tcm is one of the most frequently used clinically external treatment of Chinese medicine, " Handbook of Prescriptions for Emergencies " of Jin Daige flood work, the Thousand Golden Prescriptions of the Tang Dynasty Sun Simiao, supplement to Thousand Golden Prescriptions, in " medical secrets of official " of Wang Taozhu and the Compendium of Material Medica of Ming Dynasty's Li Shizhen (1518-1593 A.D.), contained therapy has all related to external application of Chinese medicine.Because meridians have interior genus internal organs, outer network podomere, link up the exterior and the interior, run through upper and lower effect, so not only local patholoic change can be treated, but also reach the object for the treatment of systemic disease by external application.Medicine, by the stimulation to acupuncture point, back (as FEIYU acupoint, XINYU acupoint, GEYU acupoint) local, penetrates through skin, excites through feeling pulse gas, promotes internal organs QI-blood circulation, plays therapeutical effect; Row is followed by human body maximum yang channel-sun urinary bladder channel in back, when treating in back with suitable medicine, can stimulate yang channel, exciting human yang-energy, dispel cold-evil in body, improve the movable and pathological change of internal organs and tissue physiology, the immunity of enhancing body and resistance against diseases.
The pungent temperature of side's epheday intermedia, reaches on lightly floating, and be apt to open lung qi dispersing strongly fragrant, dispersing wind and cold, dredge space between skin and muscles, saturating hair key, has the title of " controlling sense first key medicine ".Herba Ephedrae is the special medicine of lung meridian, is the key medicine of depressed lung-energy dispersing.The pungent perfume (or spice) of Herba Asari is walked to alter, and has and rises a floating property, outward can warm dispersing wind and cold, has the merit of antipyretic-antalgic, helps Herba Ephedrae relieving the exterior syndrome by diaphoresis, join the Rhizoma Zingiberis Recens of warming the meridian and promoting blood circulation, urgees antiperspirant and separates the heresy of wind and cold.Rhizoma Belamcandae purging with bitter and cold drugs, can lung heat clearing expel the heat-evil, falling expectorant and relieving asthma, resolving toxin and disinhibiting the throat, is laryngopharynx swelling and pain key medicine.The bitter gentle lung benefit gold of Radix Asteris, specially can using pungent drugs for dispersion and bitter drugs for purgation lung strongly fragrant, surely cough sending down the abnormal ascending QI, a surname is logical to stop up stagnant, holds concurrently and dredges lung man QI and blood.Flos Farfarae bitter in the mouth master falls, and along the gas in lung, the blood again in lung heat clearing, the lung moistening of energy dissipating depression of QI, preventing phlegm from forming and stopping coughing, has heresy to fall apart, and fall apart and do not let out, naivete can moisten, and moistens and does not tremble with fear." sick phlegm retention person, when with warm medicine and it ".Drink non-Wen Buhua, the non-gas of expectorant falls and does not disappear.Herba Ephedrae, Herba Asari, the Rhizoma Pinelliae, sending down the abnormal ascending QI expectorant, warming the lung to resolve fluid-retention is in interior.The acid of Fructus Mume, Fructus Schisandrae Chinensis, with tonifying for the deficiency, makes healthy energy from holding back; Radix Scutellariae, Folium Pyrrosiae, Fructus Cannabis bitter cold, can clearing heat and expelling damp reduce phlegm; The product that Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Ramulus Cinnamomi, another name for Sichuan Province green pepper are all warm, can warm up spleen and help fortune by the kidney warming; Radix Codonopsis, Radix Angelicae Sinensis vigorate qi and replenish the blood and righting, to mend the day after tomorrow.Semen Sinapis Albae, Fructus Piperis Longi have dispels various pertinacious phlegm in body; Rhizoma Corydalis has invigorates blood circulation, dissipating blood stasis, the merit of regulating the flow of vital energy.All medicines are harmonious, and have Wen Bingyong clearly, the effect of resolving phlegm and relieving asthma, for the bronchial wheezing of coldheat complex, deficiency of vital QI, and Be very effective.
Herba Ephedrae, acrid in the mouth, micro-hardship, warm in nature.There is relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, the effects such as inducing diuresis to remove edema.Herba Ephedrae begins to be loaded in " herbal classic ", is classified as middle product.Containing the composition such as ephedrine and pseudoephedrine in Herba Ephedrae.Ephedrine has the effect of vasoconstrictive raising blood pressure, also has excitation to heart.Its boosting is slowly lasting, and pressor action temperature is with lasting.Ephedrine has excitation to maincenter, and larger therapeutic dose can excited cerebral cortex and subcortical center, also can excited respiratory center and vasomotor center, has the effect of reviving, can be used for narcolepsy when anesthetics is poisoning.Ephedrine has more lasting spasmolysis to bronchial smooth muscle, acts on iris radial muscle and can make platycoria, and gastrointestinal tract also can be made of flaccid muscles, suppresses to wriggle, and excited isolated uterine, bladder expand about flesh; Ephedrine has antifatigue effect to skeletal muscle, can promote by curare conduction between the neuromuscular that suppresses, ephedrine and total alkaloids to the cat of normal and heating all without perspiration.Pseudoephedrine also has the effect of boosting vasoconstrictive, lax bronchial smooth muscle, and has stronger diuresis compared with ephedrine.Mainly it is combined with adrenoreceptor the action principle of ephedrine, and a part is the indirect factor owing to promoting medium release.Easily produce tachyphylaxis when ephedrine is applied repeatedly, effect weakens rapidly, finally can disappear completely.
Rhizoma Belamcandae, Rhizoma Belamcandae bitter in the mouth, cold in nature, return lung meridian.Tool eliminating fire and detoxication, expectorant, the effects such as sore-throat relieving.Cure mainly the pent-up of pyretic toxicity abundant expectoration, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma etc.Rhizoma Belamcandae begins to be loaded in Shennong's Herbal, is classified as low-grades.Compendium of Material Medica is carried: " Rhizoma Belamcandae, can pathogenic fire reducing, thus ancient prescription to control sore throat pharyngalgia be key medicine.Grandson true man's " prescriptions worth thousand gold " control sore throat black Wooden-fan cream.Zhang Zhongjing " the deficient beautiful letter of gold " side controls cough and dyspnea, makes water bird sound, have belamcanda mahuangtang in larynx.The female biejiajian pills for the treatment of malaria again, also fans with crow and burnt, and all gets it and falls the moon of fainting fire is also mutually.Fire falls, and loose the swelling of blood disappears, and expectorant knot explains , mass in the abdomen by oneself from removing." Rhizoma Belamcandae is control the conventional medicine of laryngopharynx swelling and pain, can heat clearing away poison, detumescence pain.
Herba Ephedrae: bitter cold, pathogenic fire reducing expectorant, sore-throat relieving is relievingd asthma; The pungent temperature of Herba Ephedrae, warming lung for dispelling cold, opens lung qi dispersing gas.
Radix Scutellariae: Radix Scutellariae nature and flavor bitter cold, clearing away heat-fire, is apt to away the part of the body cavity above the diaphragm housing the heart and lungs, enters lung meridian, and clearing away lung-heat lets out lung-fire; It is also bitter cold that Rhizoma Belamcandae is hidden, but except the merit of tool heat-clearing and toxic substances removing, still has the length of the sore-throat relieving that reduces phlegm.
Rhizoma Pinelliae Preparata, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness.Outer subduing inflammation., vomiting regurgitation dizzy for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant, breast gastral cavity painful abdominal mass are vexed, globus hystericus disease; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.(1) drying dampness to eliminate phlegm: for damp-phlegm, cold-phlegm that expectorant is rare and many clearly, often join Pericarpium Citri Reticulatae.(2) stopping nausea and vomiting by lowering the adverse flow of QI: the merit quite work of stopping nausea and vomiting by lowering the adverse flow of QI, can be used for various vomiting, is especially suitable for the vexed vomiting of the gastral cavity caused by turbid damp obstructing in middle-JIAO, often joins Rhizoma Zingiberis Recens, Poria.Heat syndrome is vomitted, and should join heat clearing and fire purging medicine.(3) reducing swelling and alleviating pain: sore swollen toxin, venom are controlled in external.1. " herbal classic ": main typhoid fever cold and heat, hardness in the epigastrium, the therapeutic method to keep the adverse QI flowing downwards, laryngopharynx swells and ache, and dizziness breast is swollen, cough with dyspnea, borborygmus, hidroschesis.2. " not Lu ": the full knot of diabetes with polydipsia as the prominent symptom abdomen chest and diaphragm expectorant heat, cough with dyspnea, the hard painful abdominal mass of acute pain in the epigastrium, seasonal epidemic pathogens vomiting; Subduing inflammation, induced abortion, treats dull yellowish colored skin, happy damp appearance.Raw make us telling, ripely to make us down.3. " property of medicine opinion ": expectorant saliva, appetite promoting and the spleen strengthening, anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot.New survivor rub be coated with carbuncle do not disappear, can tumor wart be removed.The deficiency of vital energy and have mental disorder, adds and uses it.4. " Japan hanako materia medica ": control and tell food regurgitation, cramp caused by acute vomiting and diarrhea, intestinal abdomen is cold, intermittent fever due to phlegm.5. " Bencao Tujing ": main stomach is cold, to vomit the sound of vomiting.6. " medicine origin ": control cold-phlegm and cold physique and to admire cold injury lung and coughing, large easing stomach-QI, except cold syndrome of the stomach, enter diet.Control the headache of sun syncope due to accumulation of phlegm, non-this can not remove." curing mainly secret wanting " cloud, dry stomach wets, and reduces phlegm, strengthening the spleen gastric qi, dispersing swelling and dissipating binds, removes sputum in the heart.7. Zhu Zhenheng: control supraorbital bone pain.8. " detailed outline ": control abdominal distention, order must not be closed the eyes, nebulousurine, nocturnal emission, leukorrhagia.All blood disorders and deficiency of YIN cough caused by dryness, Tianjin are hindered thirster and are avoided clothes.1. Collective Notes to the Canon of Materia medica: Rhizoma Belamcandae makes for it.2. " property of medicine opinion ": avoid Sanguis caprae seu ovis, Sargassum, maltose.Radix Bupleuri makes for it.3. Zhang Yuansu: all blood disorders and thirster's forbidding.Anemia of pregnant woman avoids it, then harmless with Rhizoma Zingiberis Recens.4. " Elementary Medicine ": all blood disorders and spontaneous perspiration, thirsty person's forbidding.5. Rhizoma Pinelliae improper use can cause poisoning, shows as dispute throat itch numb, hoarseness, slurred speech, sialorrhea, the sense of taste disappears, nausea and vomiting, uncomfortable in chest, can there is laryngospasm in abdominal pain diarrhea severe patient, dyspnea, quadriplegia, blood pressure drops, hepatic and renal function injure etc., finally can be dead because of respiratory center paralysis.
Rhizoma Atractylodis Macrocephalae preparata, invigorating the spleen to arrest diarrhea.For diarrhea due to hypofunction of the spleen, chronic dysentery, or the disease such as the pouring band nebulousurine of women.1, for deficiency-weakness of spleen-QI, the diseases such as anorexia and loose stool, distension and fullness in the abdomen, lassitude caused by dysfunction of the spleen in transportation and transformation.2, for insufficiency of the spleen can not transporting, water-damp retention, and be the diseases such as phlegm retention edema.3, for deficiency of the spleen causing weakness of QI, and the not solid spontaneous perspiration of flesh table.4, for the card of pregnant deficiency of the spleen causing weakness of QI, nausea uneasiness.
Poria, promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieves internal heat anticancer.Mild in medicine property and, dampness removing and do not hinder healthy energy.Take in right amount can be used as spring and summer wet season take good care of good merchantable brand.Dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis can be controlled, have loose bowels, pass out semen, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful.Contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.Can be relaxed gastrointestinal smooth muscle, the effects such as gastric acid secretion inhibiting, prevents hepatic necrosis, antibacterial.Main component in Poria is pachyman, and content is very high.Inhibitory action is had to various bacteria; Can gastric acid be fallen, have preventive effect to digestive tract ulcer; Significant protective effect is had to hepatic injury; There is antineoplastic action; Many-sided immunologic function can be regulated; Leukopenia caused by chemotherapy can be made to accelerate; And have calm effect.
Exocarpium Citri Rubrum, cold expelling, dampness, promoting the circulation of QI, expectorant.Get sick from drinking too much wine for cough due to wind and cold, itching of the throat abundant expectoration, food stagnation, jailbird is vexed.Preventing phlegm from forming and stopping coughing, cough due to wind and cold, the primary effect of Exocarpium Citri Rubrum, no matter tremble with fear and cough or dry cough, take Exocarpium Citri Rubrum all can take effect, cough is divided into heat syndrome cough and trembles with fear coughs two kinds: heat syndrome cough is the recurrent cough caused by lung-heat, such as excessive edible food of getting angry, as food such as frying, Broiled Dishes, show as that throat is dryly itched, the few expectorant of dry cough or expectorant yellow skin matter sticky; Trembling with fear and cough, how causing by catching cold, show as itching throat and cough frequently, sputum is thin in cystose.Food stagnation is got sick from drinking too much wine, change general regulating the flow of vital energy, the good merchantable brand of the personage that smokes and drink, tobacco and wine to lung stomach liver and throat damage maximum, live in city automobile and industrial waste gas is in the majority, permanent suction excessively easily causes habitual respiratory tract infection inflammation afterwards simultaneously.Informal dress Exocarpium Citri Grandis just can alleviate ethanol and waste gas to the infringement of these human organs.Vomiting singultus, eating accumulation, the personages such as frequent dinner party dinner party answer informal dress Exocarpium Citri Grandis, and Exocarpium Citri Grandis is to the stagnant good effects that has that disappears of the intestines and stomach, and one after each meal can make alleviating in stomach and digest pressure.
Periostracum Cicadae is sweet in the mouth, salty, cool in nature.Return lung, Liver Channel.There is dispelling wind and heat pathogens, relieving sore throat to recover voice, rash, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion effect.For anemopyretic cold, epidemic febrile disease is from the beginning of, pharyngalgia hoarseness, and measles without adequate eruption, rubella pruritus, cataract, anxious chronic infantile convulsion, tetanus is demonstrate,proved, and the nocturnal fretfulness in infants is uneasy.1, anemopyretic cold, epidemic febrile disease is from the beginning of, pharyngalgia hoarseness.This product clearing away heat with drugs sweet in flavor and cold in nature, light weight floats, and is longer than to evacuate wind and heat in the lung meridian and treat mute with lung qi dispersing sore-throat relieving, sound producing, therefore anemopyretic cold, epidemic febrile disease from the beginning of, disease sees hoarseness or laryngopharynx swelling and pain person, particularly suitable.With control anemopyretic cold or epidemic febrile disease from the beginning of, fever and aversion to wind, headache thirster.Red swelling and pain of throat, hoarseness that treatment wind heat fire-toxin is attacked.2, measles without adequate eruption, rubella pruritus.This product a surname is loose to be sent out thoroughly, dispelling wind and heat pathogens, and rash is antipruritic, with controlling wind heat external beam, measles without adequate eruption; With dispelling the wind and dampness pathogens contamination skin blood vessels, skin pruritus.
Pheretima, cold in nature, salty in the mouth.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, dredging collateral.Return liver, stomach, lung, urinary bladder channel.Function heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind, relieving asthma, diuresis, dredging collateral eliminating impediment.Cure mainly that high heat agitation, infantile convulsion tic, dyspnea and cough due to lung-heat, accumulation of heat urine retention, arthralgia pain limb are numb, hemiplegia, and the card such as sore swollen toxin.This product can be used for the asthma of lung-heat.Inducing diuresis to remove edema.For damp and hot edema.Maximum are dredging collateral and relieving asthma.Relieving asthma and can alleviate the spasm of bronchial smooth muscle exactly.Clearing lung, relieving asthma, for lung-heat asthma.This product again clearing away lung-heat is relievingd asthma.With controlling accumulatiorn of pathogenic heat in the lung, gasping for breath of impairment of purifying and descending function of the lung, whistling sound in the throat person, namely alone grinding into powder for oral administration imitate.
Radix Peucedani, cold nature, bitter in the mouth, pungent.Return lung meridian.Dispelling wind-heat, the therapeutic method to keep the adverse QI flowing downwards, expectorant.Control headache due to pathogenic wind-heat, expectorant heat syndrome cough is breathed heavily, vomiting, and chest and diaphragm is full vexed." detailed outline ": " Radix Peucedani is brothers' medicines that too yin, yang is bright, rises with the pure sun of Radix Bupleuri, enters few sun, faints cloudy person's difference also.Its merit is longer than the therapeutic method to keep the adverse QI flowing downwards, therefore can control that expectorant dyspnea of heat type is coughed, painful abdominal mass diaphragm vomiting promise disease.Under gas, then fire falls, and expectorant also falls, and oldly causing new achievement so have to push away, is mental disorder key medicine.TAO Hong-Jing says that itself and Radix Bupleuri are non-with merit, though control card with, institute enter lead then different."。" explaining abstruseness of the canon of materia medica ": " Radix Peucedani, lung liver medicine also.Loose wind drives heat, the expectorant therapeutic method to keep the adverse QI flowing downwards, appetizing relieving dyspepsia, and preventing or arresting vomiting Dingchuan is antiabortive except coughing, the only nocturnal fretfulness in infants.Radix Bupleuri, Radix Peucedani, be wind medicine, but the main liter of Radix Bupleuri, Radix Peucedani master reduces to different ear.All powers, be all the effect of searching the wind therapeutic method to keep the adverse QI flowing downwards, liver and gall are patient through wind-phlegm, give up this and can not treat.Avoid fire."
Fructus Mume, nature and flavor are sour, puckery, flat, return liver, spleen, lung, large intestine channel." Bencao Tujing " describes when mentioning effect of Fructus Mume like this: " main typhoid fever dysphoria with smothery sensation and cholera yearningly hot-tempered, the thin win of asthenia, puerpera's diarrhea due to disorder of qi etc. side in multiplex it." Fructus Mume can astringing lung-QI and relieving cough, relieving diarrhea with astringents, admittedly collapse hemostasis, promoting the production of body fluid to quench thirst, relieving colic caused by ascaris.Often be used to treat chronic cough, deficiency-heat excessive thirst, chronic malaria, chronic diarrhea, dysentery, has blood in stool, hematuria, metrorrhagia, and ascariasis of biliary tract stomachache, vomiting, ancylostomiasis etc., effect is obvious." medication heart method ": " receive lung qi." " detailed outline ": " astringing intestine to stop diarrhea of astringing the lung, control chronic cough, dysentery, regurgitation is dysphagic, ascariasis of biliary tract vomiting and diarrhea, and detumescence, gushes expectorant, parasite killing, separates ichthyotoxin, horse mump, sulfur poison."
Herba Asari, acrid in the mouth, warm in nature.Effect: dispersing wind-cold, wind-expelling pain-stopping, warming the lung to resolve fluid-retention.Cure mainly cold, fever with chills, headache general pain, nasal obstruction watery nasal discharge; Headache toothache, rheumatic arthralgia; The diseases such as abundant expectoration cough.Main containing volatile oil, composition such as this fat element class and higenamine etc.Volatile oil has antitussive effect.Herba Asari volatile oil, methyleugenol, higenamine all can diastole bronchial smooth muscle and have antiasthmatic effect.The quiet note of China kakuol preserved material rabbit can to the respiration inhibition caused by anti-morphine ab.Volatile oil is to isolated uterine, the intestinal tube of rabbit, and low concentration makes tension force first increase rear decline, and high concentration then suppresses; Relexation is had to the Ileum From A White spasmodic contraction caused by histamine; Be inhibitory action to Isolated Rat Uterus.
Rhizoma Zingiberis, acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Have warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention effect.For coldness and pain in the epigastrium, vomiting and diarrhoea; Lung cold chronic cough is panted, the diseases such as abundant expectoration is rare clearly.There is antiulcer, suppress intestinal contraction, function of gallbladder promoting, anti-hypoxia, antithrombotic and antiplatelet aggregation, town to be told, antipyretic, analgesia, antiinflammatory, antibacterial, the effect such as spiral shell, schistosomicide of going out.Rhizoma Zingiberis is containing volatile oil, and in oil, main component is zingiberene, zingiberol, phellandrene, camphene, citral, gingerol, Borneolum Syntheticum, neral etc., still resinous and starch in addition.Rhizoma Zingiberis preserved material can suppress the secretion of gastric acidity and gastric juice.The Multiple components of Rhizoma Zingiberis Recens can bring out laboratory animal autonomic movement to be suppressed; The ether extract of Rhizoma Zingiberis and water extract all have significantly analgesia and antiinflammatory action.Intravenous injection Rhizoma Zingiberis preserved material, has transient boosting and hypotensive effect then, and can strengthen autonomic activities; Rhizoma Zingiberis preserved material and Rhizoma Zingiberis preserved material and Rhizoma Pinelliae preserved material share Shi Junke makes isolated heart autonomic movement strengthen.The direct excited heart of ethanol extract energy of Rhizoma Zingiberis Recens, has excitation to vasomotor center.Ginger ale extract and volatile oil thereof have obvious preventive effect to experimental vein thrombosis.The ether extract of Rhizoma Zingiberis can slow down the keto consumpting speed of overall mice and improve hypoxia-bearing capability.Rhizoma Zingiberis preserved material can suppress vascular permeability, has diuresis with Rhizoma Pinelliae preserved material with the used time.Rhizoma Zingiberis has town to vomit, calmness, analgesia, dispelling-wind invigorating stomach, antitussive action.
Folium Pyrrosiae, sweet, bitter, be slightly cold.Return lung, urinary bladder channel.Function cures mainly: inducing diuresis for treating stranguria syndrome, clearing away heat to stop bleeding.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, spits blood, epistaxis, hematuria, metrorrhagia, dyspnea and cough due to lung-heat.
Radix Angelicae Sinensis, Radix Angelicae Sinensis sweet in the mouth, pungent, micro-hardship, warm in nature; Return liver, the heart, spleen channel; Fragrant strongly fragrant row falls apart, and can rise and can fall; Effect of Radix Angelicae Sinensis and effect have enriches blood, and invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation; Cure mainly blood deficiency, all diseases of blood stasis; Dizziness and headache, cardiopalmus limb fiber crops, menoxenia, amenorrhea, dysmenorrhea, metrorrhagia, knot is poly-, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, heavy after bloody dysentery, dryness of the intestine dyschezia, treating swelling and pain by traumatic injury, ulcer sores.Materia Medica of Decoction: Radix Angelicae Sinensis, few the moon of starting with, with the main blood of its heart also; Enter foot lunar, wrap up in blood also with its spleen; Enter sufficient the moon of fainting, with its blood stored in the liver also.Head can removing blood stasis, and body can nourish blood, the promoting the circulation of blood of tail energy, user regardless of, not as not making.If use entirely, all can enrich blood at ginseng, stilbene; Leading a cow, Radix Et Rhizoma Rhei, all can removing blood stasis, assistant makes fixed point, and user is when know.From osmanthus, attached, the Fructus Evodiae is then hot; Then tremble with fear from Radix Et Rhizoma Rhei, Natrii Sulfas.Only wine Radix Angelicae Sinensis (steamed), controls headache again, with its all headache all belong to wood, therefore with blood medicine master it.
Another name for Sichuan Province green pepper, acrid in the mouth, hot in nature, return spleen, stomach warp; Effect: fragrant stomach invigorating, warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing detoxifies, antipruritic solution raw meat; Cure mainly: vomiting, anemofrigid-damp arthralgia, the diseases such as toothache.Except the stink smell of various meat; Promote salivation, increase appetite; Distend the blood vessels, thus play the effect reduced blood pressure.
Ramulus Cinnamomi, acrid in the mouth, sweet, warm in nature; GUIXIN, lung, urinary bladder channel.Diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation.Control exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea lump in the abdomen.Ramulus Cinnamomi is containing volatile oil 0.69%, in oil, main component is cinnamic aldehyde (cinnamaldehyde) 64.75%, also has benzyl benzoate (benzylbenzoate), cinnamyl acetate (cinnamylacetate), β-cadinene (β-cadinene), Chang Pu alkene (calamenene), coumarin (coumarin) etc." book on Chinese herbal medicine is not mentionleted alone ": Zhong Jing treatise on Febrile Diseases diaphoresis Ramulus Cinnamomi.Ramulus Cinnamomi person, branch, non-body is dry also.Get it frivolous and can disperse.There is again a kind of Liu Gui the present, be the tender small stems in osmanthus also, it is especially pleasant that to control the part of the body cavity above the diaphragm housing the heart and lungs also medicinal.
Radix Codonopsis, sweet, flat.Return spleen channel, lung meridian.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper.”
Fructus Cannabis, sweet, flat.Return spleen, stomach, large intestine channel.Function cures mainly: loosening bowel to relieve constipation.For blood deficiency and depleted fluid, dryness of the intestine constipation.
Radix Asteris, bitter in the mouth is pungent, warm in nature.Xin Kaixuan is loose, hardship can fall let out, gentle soft and moist, therefore have the effect of nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Pulmonary can be controlled and have phlegm dyspnea cough that is cold, obstruction of lung-QI; There is heat in Neng Zhi pulmonary, coughs the lung abscess of vomiting bloody pus again.This product temperature and not hot, embellishes but not dry, so all suitable to lung cold, lung-heat." herbal classic ": " main cough with dyspnea, in the heart cold and heat stagnation of QI remove diseases due to noxious agents produced by various parasites, flaccidity Jue, An Wuzang." " book on Chinese herbal medicine is new again ": " nourishing the lung to keep the adverse QI downward, cold-phlegm and dyspnea due to deficiency person should it."
Flos Farfarae, acrid, sweet, warm.Enter lung meridian.There is nourishing the lung to arrest cough, expectorant therapeutic method to keep the adverse QI flowing downwards effect.1. nourishing the lung to keep the adverse QI downward: this product is sweet can mend, and pungent energy falls apart, temperature energy cold expelling, therefore can be used for the cards such as pulmonary distension, consumptive lung disease, pulmonary tuberculosis, lung abscess.1. for consumptive lung disease, because insufficiency of lung-QI, failure of qi transforming fluid, body fluid are saliva, disease opinion coughs up salivation, and clear rare amount is many, not yearningly, breathes hard, and spiritlessness and weakness joins the product of the spleen strengthening and damp drying by this product.2. for lung abscess, i.e. lung abscess, can be equal to Rhizoma Phragmitis, Semen Coicis, Semen Persicae, Semen Benincasae and use.3. for pulmonary distension, i.e. emphysematic patients.2. relieving cough and asthma: this product has effect of warming for resolving cold-phlegm, nourishing lung-YIN, preventing phlegm from forming and stopping coughing, can treat cold-evil attack lung and cause cough, asthma card.For phlegmatic cough asthma, meet cold, send out; If cough band blood, can grind honeyed pill into powder with Bulbus Lilii; If cruelly cough with controlling.This product temperature and not hot, pungent and not dry, sweet and not stagnant, be the good medicine of moistening the lung and resolving phlegm antitussive, all coughs all belong to lung patient, no matter Exogenous and internal injuries, cold and heat and asthenia and sthenia, all can adapted.
Fructus Schisandrae Chinensis, sour, sweet, temperature.Return lung, the heart, kidney channel.Fructus Schisandrae Chinensis as medical material, record the earliest be listed in Shennong's Herbal top grade.Ancients once evaluated like this Fructus Schisandrae Chinensis " the sweet acid of Fructus Schisandrae Chinensis skin and flesh, core first are worked hard, have saline taste this then the five tastes are all also." modern pharmacological research shows; Radix Schisandrae Bicoloris contains multiple nutritional components; as schizandrin, malic acid, citric acid, tartaric acid, succinic acid, fatty oil, volatile oil, saccharide, resin, vitamin C etc., also containing trace element such as tungsten, ferrum, manganese, zinc, phosphorus.
Radix Scutellariae, bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Principle active component: flavone compound." Bencao Jingshu ": the hot person of the spleen deficiency of the lung avoids it.All invasion by pathogenic cold is let out, and invasion by pathogenic cold is suffered from abdominal pain, and the empty and lower abdominal pain of Liver and kidney, abdominal pain due to deficiency of blood, diarrhea due to hypofunction of the spleen, half congealed rushing down of suffering from a deficiency of the kidney, edema due to deficiency of the spleen, amenorrhea due to blood depletion, the little water of the deficiency of vital energy is unfavorable, and lung is breathed with cough by cold-evil, and blood deficiency tire is uneasy, and the deficiency of YIN is drenched and revealed, and method is also forbidden.
Semen Sinapis Albae, pungent, temperature.Enter lung, stomach warp.There is promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain effect.Control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury." detailed outline ": " promoting the circulation of QI eliminating phlegm, except in cold warming up, loose swollen pain relieving.Control and breathe heavily regurgitation of coughing, numbness wood beriberi, muscles and bones waist saves all pains.”
Rhizoma Corydalis, acrid in the mouth, hardship, warm in nature.There is promoting blood circulation to remove blood stasis, the function of promoting the circulation of QI pain relieving.For whole body each portion qi depression to blood stasis pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.Be decocted in water for oral dose.Shi Zhen concludes Rhizoma Corydalis in Compendium of Material Medica " invigorating blood circulation, promoting the circulation of QI, pain relieving, diuresis " four large effects, and praises highly Rhizoma Corydalis " can the stagnation of QI in promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body ".The traditional Chinese medical science is thought, Rhizoma Corydalis pungent loose, hardship is let out, Wen Tong, both enters blood system, and enters edema caused by disorder of QI again, can gas in promoting the circulation of blood, again can blood in circulation of qi promoting, the smooth blood of gas, general rule is not bitterly.
Fructus Piperis Longi, pungent, heat.Enter spleen, stomach warp.There is warming middle-JIAO, cold expelling, the therapeutic method to keep the adverse QI flowing downwards, analgesic efficacy.Control trusted subordinate's cold type of pain, vomiting acid regurgitation, increased borborygmus and diarrhea, cold-dysentery, scrotal hernia, headache, nasal sinusitis, toothache.Supplement to the Herbal: " warming the middle warmer and descending qi, mends waist foot, helps digestion, except stomach is cold, scrotal hernia, mass beside the umbilicus." excess-heat stagnated fire, hyperactivity of fire caused by deficiency of YIN person all avoid clothes.1. amplification on Canon of Materia Medica: " many clothes are walked to let out vital qi, heavy under making us intestinal void." 2. " detailed outline ": " hot dissipation, the fire of active spleen lung, multiplexly makes us blurred vision, foodstuff especially unsuitable it."
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 capsule
Embodiments provide a kind of Chinese medicine composition being used for the treatment of intermingling cold and heat bronchial wheezing, Chinese medicine composition is made up of following raw medicinal material: Herba Ephedrae 1500g, Rhizoma Belamcandae 1500g, Rhizoma Pinelliae Preparata 1500g, Rhizoma Atractylodis Macrocephalae preparata 1500g, Poria 1600g, Exocarpium Citri Rubrum 1800g, Periostracum Cicadae 1200g, Pheretima 1500g, Radix Peucedani 1500g, Fructus Mume 1600g, Herba Asari 1000g, Rhizoma Zingiberis 1500g, Folium Pyrrosiae 1200g, Radix Angelicae Sinensis 1800g, another name for Sichuan Province green pepper 1300g, Ramulus Cinnamomi 1400g, Radix Codonopsis 1600g, Fructus Cannabis 1400g, Radix Asteris 1500g, Flos Farfarae 2000g, Fructus Schisandrae Chinensis 1500g, Radix Scutellariae 1500g, Semen Sinapis Albae 1300g, Rhizoma Corydalis 1700g and Fructus Piperis Longi 1700g.
The embodiment of the present invention additionally provides a kind of preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, and the dosage form of Chinese medicine composition is capsule, and its preparation method comprises the following steps:
A, take Rhizoma Pinelliae Preparata, Exocarpium Citri Rubrum, Semen Persicae and stir-fried kidney beans according to above-mentioned weight, add the water soaking 1.5 hours of 7 times amount, extract the volatile oil of 4 hours, collect volatile oil, medicinal liquid filters, and medicinal residues are for subsequent use; Wherein, employing supercritical fluid extraction is extracted;
B, the medicinal residues that step a is obtained and remain other raw medicinal materials mixing mixture, adding alcoholic degree is 75% ethanol, soaks 1 hour, extract 3 times, each 2 hours, add the ethanol of 10 times of mixture qualities for the first time, second time adds the ethanol of 10 times of mixture qualities, merge extractive liquid, filters; Above-mentioned twice filtrate is merged and filters again, by carry out again filtering filtrate reduced in volume to the relative density obtained be 80 DEG C time 1.30, precipitate with ethanol twice, adjusts concentration of alcohol 75%, when to get supernatant concentration to relative density be 80 DEG C 1.40, obtains extractum; Wherein, employing membrane separation technique is extracted;
C, get the extractum that step b obtains, add volatile oil and vegetable oil, mixing, grinds 10 minutes with colloid mill, constantly stirs, be chilled to room temperature, obtain Chinese medicine composition, incapsulated by Chinese medicine composition in housing, obtain capsule finished product.
Embodiment 2 patch
Embodiments provide a kind of Chinese medicine composition being used for the treatment of intermingling cold and heat bronchial wheezing, Chinese medicine composition is made up of following raw medicinal material: Herba Ephedrae 1400g, Rhizoma Belamcandae 1200g, Rhizoma Pinelliae Preparata 1200g, Rhizoma Atractylodis Macrocephalae preparata 1800g, Poria 1700g, Exocarpium Citri Rubrum 1900g, Periostracum Cicadae 1000g, Pheretima 1000g, Radix Peucedani 1800g, Fructus Mume 1700g, Herba Asari 900g, Rhizoma Zingiberis 1700g, Folium Pyrrosiae 1000g, Radix Angelicae Sinensis 1900g, another name for Sichuan Province green pepper 1200g, Ramulus Cinnamomi 1700g, Radix Codonopsis 1800g, Fructus Cannabis 1900g, Radix Asteris 1800g, Flos Farfarae 1500g, Fructus Schisandrae Chinensis 1600g, Radix Scutellariae 1700g, Semen Sinapis Albae 1500g, Rhizoma Corydalis 1800g and Fructus Piperis Longi 1800g.
The embodiment of the present invention additionally provides a kind of preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, and the dosage form of Chinese medicine composition is patch, and its preparation method comprises the following steps:
A, take all raw medicinal materials by described ratio of weight and number, add in 75% ethanol of 10 times amount, heating and refluxing extraction 2 times, each 1.5 hours, extracting solution extracted twice obtained merges and obtains extracting solution one, and left standstill by extracting solution one, medicinal residues are for subsequent use;
B, by the medicinal residues in step a, the heating and refluxing extraction that adds water 1 time, each 1 ~ 2 hour, extracts to obtain extracting solution two, leaves standstill;
Extracting solution two merging that c, the extracting solution one obtained by step a and step b obtain, in suction concentrating under reduced pressure tank, be decompressed to 0.05MPa, temperature remains on 70 DEG C, and being concentrated into the relative density when temperature is 65 DEG C is 1.20 extractum; Namely patch is obtained after being in harmonious proportion with wine, vinegar, Mel.
Umbilicus, cave name Shenque, for the important acupuncture point of conception vessel, what Gu had " Shenque, cures mainly all kinds of diseases and ailments, and old man, empty people have loose bowels as god " says, position, umbilicus place is again that chong channel is through row part, Conception Vessel and Governor Vessel is the exterior and the interior each other, and commander's human body is all through hundred arteries and veins, therefore umbilical part is maintained close ties with by above meridians and all internal organs organs of whole body.Human body stomach wall is thin, and local application is easy to absorb, and no pain, the patch external application Shenque of the embodiment of the present invention can reach dispelling cold and activating YANG, regulating QI to relieve pain, function of spleen and stomach regulating.
Embodiment 3 tablet
Embodiments provide a kind of Chinese medicine composition being used for the treatment of intermingling cold and heat bronchial wheezing, Chinese medicine composition is made up of following raw medicinal material: Herba Ephedrae 1400g, Rhizoma Belamcandae 1200g, Rhizoma Pinelliae Preparata 1200g, Rhizoma Atractylodis Macrocephalae preparata 1800g, Poria 1700g, Exocarpium Citri Rubrum 1900g, Periostracum Cicadae 1000g, Pheretima 1000g, Radix Peucedani 1800g, Fructus Mume 1700g, Herba Asari 900g, Rhizoma Zingiberis 1700g, Folium Pyrrosiae 1000g, Radix Angelicae Sinensis 1900g, another name for Sichuan Province green pepper 1100g, Ramulus Cinnamomi 1700g, Radix Codonopsis 1800g, Fructus Cannabis 1900g, Radix Asteris 1800g, Flos Farfarae 1800g, Fructus Schisandrae Chinensis 1600g, Radix Scutellariae 1700g, Semen Sinapis Albae 1500g, Rhizoma Corydalis 1800g and Fructus Piperis Longi 1800g.
The embodiment of the present invention additionally provides a kind of preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, preparation method comprises the following steps: first all raw medicinal materials are put into 10 times amount 82% ethanol, heating and refluxing extraction twice, each 45 minutes, extract active ingredient, merged by extracted twice liquid and leave standstill, obtain extracting solution one, medicinal residues are for subsequent use; Medicinal residues are added 10 times of water gagings, heating and refluxing extraction three times, each 1 hour, three extracting solution are merged, obtains extracting solution two; Merge extractive liquid, one and extracting solution two, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when filtrate relative density is about 20 DEG C 1.06; Be the macroporous adsorptive resins eluting twice of 10L through volume by filtrate, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain raw material medicinal liquid; Add starch and be pressed into tablet.
Pharmacology pharmacodynamic is tested:
1, cumulative toxicity test report
Test method: the tablet of the embodiment of the present invention 3 is pressed 7.81,18.34 and 40.11g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to rat, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine composition of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine composition of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
2, acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 16 ~ 20g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Capsule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 5.0g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 793 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety
3, acute skin irritation test
The embodiment of the present invention 2 Traditional Chinese medicine composition patch carries out Skin Irritation Test according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", choose male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, according to the method for " acute dermal toxicity test ", prepare coating, then getting 0.5g directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ".Therefore, Chinese medicine composition of the present invention is to animal skin nonirritant.
4, hypersensitive test:
Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The patch 0.1g getting the embodiment of the present invention 2 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Clinical data
1, data and method
1.1 physical data: during selecting in April, 2011 in December ,-2012, the patient of the intermingling cold and heat bronchial wheezing of certain hospitalize is totally 486 examples, wherein, man 296 example, female 190, age 30-70 year.Be divided into two groups at random, treatment group 243 example, matched group 243 example.Two groups of patients comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.
1.2 diagnostic criterias: Western medicine diagnose standard: with reference to " prevention and control of bronchial asthma guide " (the asthma group revision of respirology branch of Chinese Medical Association, 2008).
1. recurrent exerbation pant, out of breath, uncomfortable in chest or cough, how with to contact allergen, cold air, physics, chemical irritation and viral upper respiratory tract infection, motion etc. relevant.
2. during outbreak at two lung audible and be dispersed in or diffusivity, wheezing sound based on expiratory phase, expiratory phase prolongation.
3. above-mentioned symptom and sign can be alleviated or spontaneous remission through treatment.
Panting 4. caused by other diseases, out of breath, uncomfortable in chest and cough.
5. its atypical clinical manifestations person's (as without obviously panting or sign), at least should possess following 1 test positive: a. brinchial provocation test or the motion activated test positive; B. the positive FEV1 of Bronchodilation Test increases >=12%, and FEV1 increases absolute value >=200ml; C. (or 2 weeks) aberration rate >=20% in peak expiratory flow (PEF) day.
Meet 1.-4. bar or 4., 5. bar person, can asthma be diagnosed as.
TCM syndrome diagosis issues " tcm internal medicine commonly encountered diseases practice guidelines " (ZYYXH/T5-2008) with reference to China Association of Traditional Chinese Medicine: 1. whistling sound in the throat during outbreak, dyspnea, very then opening mouth and lifting shoulder due to dyspnea, can not put down sleeping, or lip fingernail cyanosis.2. in repeated relapsing.Often because the factors such as abrupt change of climate, improper diet, disorder of emotion, fatigue are brought out.There are rhinocnesmus, sneeze, cough, the tendency such as uncomfortable in chest before outbreak more.3. allergies or family history is had.4. two lung audible and wheezing sounds, or with moist rale.5. blood eosinophils can increase.6. the visible acidophil of sputum smear.7. chest X-ray is generally without special change, and the visible emphysema of prolonged illness are levied.
1.3 criterions of therapeutical effect:
To observe before patient treatment, after treatment the 3rd day, after treatment the 6th day, after treatment the 9th day primary symptom (pant, cough, cough up phlegm, uncomfortable in chest) curative effect, secondary disease (heating, vexed, thirst and liking drink) extinction time, wheezing sound curative effect, eosinophils count and the index such as normalization rate, pulmonary function, foregoing all unification is filled in into observation table.The method introduced in " the guideline of clinical investigations bronchial wheezing of new Chinese medicine " of primary symptom and wheezing sound the standard of curative effect evaluation reference " asthma " and promulgation in 2002, score-system is drafted: 4 levels quantize from low to high in conjunction with asthma rule and correlation circumstance, 0 be divided into minimum, 3 be divided into the highest.Specific standards sees the following form 1.
Table 1 bronchial wheezing curative effect index scalar quantization table
Symptom Without (0) Slightly (1) Moderate (2) Severe (3)
Pant Nothing Occasionally there is outbreak, mild degree, do not affect and have a rest or activity Comparatively frequent, but do not affect sleep, dynamic then pant obvious Sit quietly obviously, can not put down sleeping, impact sleep or movable
Cough Nothing Daytime is interrupted cough, and degree is slight Frequent cough, but do not affect sleep Frequent or the apasm of coughing of cough round the clock, impact is had a rest and sleep
Cough up phlegm Nothing On a small quantity, cough up phlegm 10-15ml round the clock, or the 5-25ml that coughs up phlegm in night and early morning Have expectorant, cough up phlegm 51-100ml round the clock, or the 26-50ml that coughs up phlegm in night and early morning Amount is many, and cough up phlegm more than l00ml round the clock, or more than the 50ml that coughs up phlegm in night and early morning
Uncomfortable in chest Nothing Occasionally there is outbreak, mild degree, do not affect and have a rest or activity Sensation is comparatively frequent, but does not affect sleep Sensation obviously, can not be put down sleeping, impact sleep or movable
Wheezing sound Nothing Two lung audible and be dispersed in wheezing sound Two lung audible and more wheezing sound Two lung audible and be abound with wheezing sound
Evaluated by the above-mentioned observed content before and after comparative study treatment, integration statistics is carried out after inserting observation table, severity Scaling and observation index grading evaluation is carried out according to integral result, concrete grade scale: observation index classification: I grade (0 point), II grade (1 point), III grade (2 points), IV grade (3 points); The classification results situation of change of front and back carries out therapeutic evaluation according to observations again, concrete the standard of curative effect evaluation: invalid (classification by rudimentary be clipped to high-level or classification do not become), effectively (classification reduces by 1 rank, but be not down to I grade), it is effective that (classification reduces by more than 2 or 2 ranks, but be not down to I grade), clinic control (classification is down to I grade).
1.4 Therapeutic Method and therapeutic effect
1.4.1 treatment group is three treatment group 1-3 at random, uses the Chinese medicine composition of the different preparations of embodiment of the present invention 1-3 to treat respectively:
(1) treatment group 1:81 example patient uses the capsule of embodiment 1, twice on the one, once take 0.3-0.5g, within ten days, be a course for the treatment of, after using 2-4 the course for the treatment of continuously, drug withdrawal further consultation again in a week, statistics discovery 31 patient treatments obtain clinic control, 28 patient treatments are effective, and 22 patient treatments are effective.Treatments period, does not find the side effect that medicine brings, follows up a case by regular visits to half a year, and 31 clinic control and 27 effective patients are all without any the symptom of recurrence.
(2) treatment group 2:81 example patient uses the patch of embodiment 2,3 times on the one, is coated with by patch and is affixed on umbilicus.Within ten days, be a course for the treatment of, after using 3-5 the course for the treatment of continuously, drug withdrawal carrys out further consultation in one week again, and statistics discovery 29 patients obtain clinic control, and 27 patient treatments are effective, and 22 routine patient treatments are effective, and 3 routine patient treatments are invalid.Do not find other side effect that medicine brings during 81 routine patient treatments, follow up a case by regular visits to half a year, 29 clinic control and 27 effective routine patients for the treatment of all do not find the symptom of any recurrence.
(3) treatment group 3:81 example patient uses the tablet of embodiment 3,3 times on the one, take 0.3-0.5g 1 time, within ten days, be a course for the treatment of, after using 2-4 the course for the treatment of continuously, drug withdrawal further consultation again in a week, statistics discovery 30 patients obtain clinic control, 28 routine patient treatments are effective, and 22 routine patient treatments are effective, and 1 routine patient treatment is invalid.Do not find other side effect that medicine brings during 81 routine patient treatments, follow up a case by regular visits to half a year, 30 obtain clinic control and the 28 effective patients of example treatment all do not find the symptom of any recurrence.
1.3.2 matched group is divided into three matched group 1-3 at random, uses different medicines to treat respectively:
(1) matched group 1:81 example patient uses belamcanda mahuangtang, the Chinese medicine decoction that patient takes is the preparation of Pharmacy department of Hiser Medical Center of Qindao, every agent is decocted as 150ml × 2 bag, each 1 bag, every day 2 times, sooner or later decoction being taken warmly, continuous use is after 2 months, and drug withdrawal further consultation again in 1 week, adds up the routine patient of discovery 8 and obtain clinic control, 22 routine patient treatments are effective, 11 routine patient treatments are effective, and 40 routine patient treatments are invalid, follow up a case by regular visits to half a year, there is recurring condition after 3 routine drug withdrawals in statistics discovery 8 routine clinic control patient, treat after 22 effective routine patients wherein have 3 routine drug withdrawals and recur.In addition, there is the symptom of diarrhoea or headache in patient when drug administration.
(2) matched group 2:81 example patient takes Bronkodyl, a 200mg, 2 times on the one, after taking 2 months continuously, drug withdrawal further consultation again in 1 week, the routine patient of statistics discovery 7 obtains clinic control, and 31 routine patient treatments are effective, and 18 routine patient treatments are effective, 25 routine patient treatments are invalid, follow up a case by regular visits to half a year, statistics finds wherein to have in 7 routine clinic control patients recurring condition after 2 routine drug withdrawals, recurs after effective 8 routine patient's drug withdrawals; There is headache, feeling sick in 7 examples, the side effect such as diarrhoea when taking.
(3) matched group 3:81 example patient take prednisone, beginning dosing is 10mg every day, night decoction being taken at a draught.After taking 1 month continuously, drug withdrawal further consultation again in 1 week, the routine patient of statistics discovery 8 obtains clinic control, 33 routine patient treatments are effective, 11 routine patient treatments are effective, and 29 routine patient treatments are invalid, follow up a case by regular visits to half a year, there is recurring condition after 4 routine drug withdrawals in statistics discovery 8 routine clinic control patient, after having 11 routine drug withdrawals in 33 routine effective patients, have recurring condition; There is the side effect such as headache, flatulence in other 5 examples when taking.
Known by above-mentioned clinical trial: compared with matched group, the Chinese medicine composition of embodiment of the present invention 1-3 have healing time short, cure after the advantage that not easily recurs and have no side effect.
2, concrete case
Case 1: Hu, man, 41 years old, is defined as intermingling cold and heat bronchial wheezing according to diagnostic criteria, use the capsule of the embodiment of the present invention 1, one day twice, once taking 0.4g, ten days is a course for the treatment of, after 3 courses for the treatment of of continuous use, drug withdrawal further consultation again in a week, lung function result: FVC rising 14%, FEV1/FVC rises 10%.Follow up a case by regular visits to half a year, without relapse indications.
Case 2: Zhao, female, 57 years old, is defined as intermingling cold and heat bronchial wheezing according to diagnostic criteria, uses the patch of the embodiment of the present invention 2, subsides in a day, is coated with by patch and is affixed on umbilicus.Within ten days, be a course for the treatment of, after using 4 courses for the treatment of continuously, drug withdrawal carrys out further consultation in one week again, and lung function result: FVC rising 10%, FEV1/FVC rises 8%.Follow up a case by regular visits to half a year, without relapse indications.
Case 3: grandson, man, 69 years old, is defined as intermingling cold and heat bronchial wheezing according to diagnostic criteria, use the tablet of the embodiment of the present invention 3,3 times on the one, taking 0.4g 1 time, ten days is a course for the treatment of, after 3 courses for the treatment of of continuous use, drug withdrawal carrys out further consultation in one week again, and lung function result: FVC rising 18%, FEV1/FVC rises 13%.Follow up a case by regular visits to half a year, without relapse indications.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. be used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: 10 ~ 20 parts, Herba Ephedrae, Rhizoma Belamcandae 10 ~ 20 parts, Rhizoma Pinelliae Preparata 10 ~ 20 parts, Rhizoma Atractylodis Macrocephalae preparata 10 ~ 20 parts, 10 ~ 20 parts, Poria, Exocarpium Citri Rubrum 10 ~ 25 parts, Periostracum Cicadae 10 ~ 18 parts, Pheretima 10 ~ 17 parts, Radix Peucedani 10 ~ 20 parts, Fructus Mume 10 ~ 20 parts, Herba Asari 5 ~ 15 parts, Rhizoma Zingiberis 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, another name for Sichuan Province green pepper 10 ~ 16 parts, Ramulus Cinnamomi 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Fructus Cannabis 10 ~ 20 parts, Radix Asteris 10 ~ 21 parts, Flos Farfarae 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 16 parts, Radix Scutellariae 10 ~ 20 parts, Semen Sinapis Albae 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts and Fructus Piperis Longi 10 ~ 20 parts.
2. the Chinese medicine composition being used for the treatment of intermingling cold and heat bronchial wheezing according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: 12 ~ 18 parts, Herba Ephedrae, Rhizoma Belamcandae 14 ~ 18 parts, Rhizoma Pinelliae Preparata 12 ~ 18 parts, Rhizoma Atractylodis Macrocephalae preparata 14 ~ 18 parts, 12 ~ 19 parts, Poria, Exocarpium Citri Rubrum 14 ~ 21 parts, Periostracum Cicadae 13 ~ 15 parts, Pheretima 13 ~ 15 parts, Radix Peucedani 14 ~ 18 parts, Fructus Mume 12 ~ 19 parts, Herba Asari 5 ~ 12 parts, Rhizoma Zingiberis 12 ~ 18 parts, Folium Pyrrosiae 12 ~ 14 parts, Radix Angelicae Sinensis 14 ~ 18 parts, another name for Sichuan Province green pepper 14 ~ 15 parts, Ramulus Cinnamomi 14 ~ 18 parts, Radix Codonopsis 14 ~ 17 parts, Fructus Cannabis 14 ~ 18 parts, Radix Asteris 14 ~ 20 parts, Flos Farfarae 14 ~ 19 parts, Fructus Schisandrae Chinensis 12 ~ 15 parts, Radix Scutellariae 14 ~ 18 parts, Semen Sinapis Albae 14 ~ 18 parts, Rhizoma Corydalis 14 ~ 19 parts and Fructus Piperis Longi 13 ~ 16 parts.
3. the Chinese medicine composition being used for the treatment of intermingling cold and heat bronchial wheezing according to claim 1 and 2, it is characterized in that, described Chinese medicine composition is made up of the raw medicinal material of following parts by weight: 12 parts, Herba Ephedrae, Rhizoma Belamcandae 18 parts, Rhizoma Pinelliae Preparata 12 parts, Rhizoma Atractylodis Macrocephalae preparata 14 parts, 19 parts, Poria, Exocarpium Citri Rubrum 14 parts, Periostracum Cicadae 13 parts, Pheretima 15 parts, Radix Peucedani 14 parts, Fructus Mume 12 parts, Herba Asari 5 parts, Rhizoma Zingiberis 12 parts, Folium Pyrrosiae 12 parts, Radix Angelicae Sinensis 18 parts, another name for Sichuan Province green pepper 14 parts, Ramulus Cinnamomi 18 parts, Radix Codonopsis 14 parts, Fructus Cannabis 18 parts, Radix Asteris 14 parts, Flos Farfarae 14 parts, Fructus Schisandrae Chinensis 12 parts, Radix Scutellariae 16 parts, Semen Sinapis Albae 14 parts, Rhizoma Corydalis 18 parts and Fructus Piperis Longi 16 parts.
4. the preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing as described in claim 1-3 any one, is characterized in that, the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:
A, take above-mentioned raw materials medical material according to parts by weight, add the water soaking 1-2 hour of 5-10 times amount, extract the volatile oil of 2-5 hour, collect volatile oil, medicinal liquid filters, and medicinal residues are for subsequent use;
B, the medicinal residues that step a is obtained and remain other crude drug mixing mixture, adding alcoholic degree is 60-90% ethanol, soaks 1 hour, extract 3 times, each 2 hours, add the ethanol of 10 times of mixture qualities for the first time, second time adds the ethanol of 10 times of mixture qualities, merge extractive liquid, filters; Above-mentioned twice filtrate is merged and filters again, by 1.10-1.50 when to filter filtrate reduced in volume to the relative density obtained again be 80 DEG C, precipitate with ethanol twice, adjusts concentration of alcohol 60-90%, 1.10-1.50 when to get supernatant concentration to relative density be 80 DEG C, obtains extractum;
C, get the extractum that step b obtains, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil is 10% of extractum weight, mixing, grind 10 minutes with colloid mill, constantly stir, be chilled to room temperature and obtain Chinese medicine composition, described Chinese medicine composition is incapsulated in housing, obtains capsule finished product.
5. the preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing according to claim 4, is characterized in that, in described step a, extracts volatile oil contained by said medicine, adopts steam distillation or supercritical fluid extraction.
6. the preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing according to claim 4, is characterized in that, in described step b, extracts and adopts membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
7. the preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing as described in claim 1-3 any one, is characterized in that, the dosage form of described Chinese medicine composition is patch, and described preparation method comprises the following steps:
A, take all raw medicinal materials by described parts by weight, add in the 60-90% ethanol of 10 times amount, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extracting solution extracted twice obtained merges and obtains extracting solution one, and left standstill by extracting solution one, medicinal residues are for subsequent use;
B, by the medicinal residues in step a, the heating and refluxing extraction that adds water 1 time, each 1 ~ 2 hour, extracts to obtain extracting solution two, leaves standstill;
Extracting solution two merging that c, the extracting solution one obtained by step a and step b obtain, concentrated, obtain drug extract, the concentrated modulation of heating, obtains patch.
8. described according to claim 7, be used for the treatment of the preparation method of the Chinese medicine composition of intermingling cold and heat bronchial wheezing, it is characterized in that, in described step c, extracting solution two merging that the extracting solution one obtained by step a and step b obtain, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into the relative density when temperature is 65 DEG C is 1.20 extractum; Namely patch is obtained after being in harmonious proportion with wine, vinegar, Mel.
9. the preparation method being used for the treatment of the Chinese medicine composition of intermingling cold and heat bronchial wheezing as described in claim 1-3 any one, it is characterized in that, the dosage form of described Chinese medicine composition is tablet, described preparation method comprises the following steps: first all raw medicinal materials are put into 10 times amount 70-85% ethanol, heating and refluxing extraction 2 times, each 45 minutes, extract active ingredient, merged by 2 extracting solution and leave standstill, obtain extracting solution one, medicinal residues are for subsequent use; Medicinal residues are added 10 times of water gagings, heating and refluxing extraction 3 times, each 1 hour, 3 extracting solution are merged, obtains extracting solution two; Merge extractive liquid, one and extracting solution two, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, when filtrate relative density is about 20 DEG C 1.06; Be the macroporous adsorptive resins eluting twice of 10L through volume by filtrate, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove alcohol solvent, obtain raw material medicinal liquid; Add starch and be pressed into tablet.
10. the Chinese medicine composition being used for the treatment of intermingling cold and heat bronchial wheezing as described in claim 1-9 any one, it is characterized in that, described Chinese medicine composition endo-medicine dosage form is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup; External drug dosage forms is: fumigant, ointment, liniment, tincture, ointment, powder, patch, gel or spray.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106110068A (en) * 2016-08-01 2016-11-16 青岛市海慈医疗集团 For treating Chinese medicine composition of asthma of heat type type bronchial wheezing and preparation method thereof
CN108671218A (en) * 2018-07-18 2018-10-19 青岛市海慈医疗集团 Chinese medicine composition and preparation method thereof for treating paracmasis heavy breathing disease

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CN1857654A (en) * 2006-03-21 2006-11-08 北京阜康仁生物制药科技有限公司 Trachaitis treating preparation and its preparing process
CN103356915A (en) * 2013-07-19 2013-10-23 苏州市天灵中药饮片有限公司 Decoction for treatment of asthma

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Publication number Priority date Publication date Assignee Title
CN1857654A (en) * 2006-03-21 2006-11-08 北京阜康仁生物制药科技有限公司 Trachaitis treating preparation and its preparing process
CN103356915A (en) * 2013-07-19 2013-10-23 苏州市天灵中药饮片有限公司 Decoction for treatment of asthma
CN103356915B (en) * 2013-07-19 2015-02-11 苏州市天灵中药饮片有限公司 Decoction for treatment of asthma

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106110068A (en) * 2016-08-01 2016-11-16 青岛市海慈医疗集团 For treating Chinese medicine composition of asthma of heat type type bronchial wheezing and preparation method thereof
CN108671218A (en) * 2018-07-18 2018-10-19 青岛市海慈医疗集团 Chinese medicine composition and preparation method thereof for treating paracmasis heavy breathing disease

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