CN101342331B - Traditional Chinese medicine for treating pulmonitis and upper respiratory tract infection - Google Patents
Traditional Chinese medicine for treating pulmonitis and upper respiratory tract infection Download PDFInfo
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- CN101342331B CN101342331B CN2008102122455A CN200810212245A CN101342331B CN 101342331 B CN101342331 B CN 101342331B CN 2008102122455 A CN2008102122455 A CN 2008102122455A CN 200810212245 A CN200810212245 A CN 200810212245A CN 101342331 B CN101342331 B CN 101342331B
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Abstract
The present invention discloses a Chinese medicinal spraying agent which is used for treating pneumonia and upper respiratory tract infection. The spraying agent is prepared from raw materials of the following weight portions: 10 to 20 portions of radix scutellariae, 10 to 20 portions of reed rhizome, 10 to 20 portions of root of straight ladybell, 10 to 20 portions of peach kernel, 10 to 20 portions of leaf of loquat, 10 to 20 portions of fructus trichosanthis, 10 to 20 portions of coltsfoot flower, 10 to 20 portions of blackberry lily, 10 to 20 portions of draba nemorosa linnei, 10 to 20 portions of Chinese ephedra, 10 to 20 portions of cordate houttuynia, 10 to 20 portions of dandelion, 10 to 20 portions of natural indigo, 10 to 20 portions of aster, 10 to 20 portions of balloon-flower root, and 10 to 20 portions of radix salviae miltiorrhizae. The spraying agent adopts the Chinese medicinal materials of different medicinal effects and the scientific formula. Different methods of extraction are used to extract the effective ingredients, to pump, to filter and to package so as to prepare the spraying agent. The spraying agent can be directly sprayed in mouth, and has the advantages of no toxic side effects, convenient use, rapid diminishment of inflammation and pains, short period of treatment, difficult relapse, easy manufacture, and low costs.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine spray for the treatment of pneumonia and upper respiratory tract infection.
Background technology
Pneumonia is the very high a kind of disease of sickness rate, the bacterial species that causes pneumonia is a lot, and antibacterial also often morphs, still there is not the very strong specific drug of specific aim at present both at home and abroad, the medicine of treatment pneumonia is a lot of in the pharmacy, Therapeutic Method is not identical unexpectedly yet, and various medicines and Therapeutic Method have its oneself characteristics and curative effect separately, but has deficiency separately simultaneously yet.Therefore people are also developing new medicine and Therapeutic Method at pneumonia targetedly.
Upper respiratory tract infection is very difficult because of the affected part direct drug injection, thus oral medicine commonly used, as antibiotics class medicine and sulfonamides etc.Though this type of medicine has certain curative effect to upper respiratory tract infection, its treatment time is long, and certain toxic and side effects is arranged, and curative effect is not remarkable, and Time of Administration is long.In therapeutic process, also have and adopt Chinese medicine preparation, be about to Chinese medicine, make powder or pill again through leaching, decoct, be condensed into dry extract.These medicaments are big because of its taking dose, and clothes backs drug effect can not manifest immediately, especially pediatric patient is taken more inconvenient, so influence applying of such Chinese powder medicine or pill.
Some upper respiratory tract infection disease is clinical common, is difficult to radical cure and easily outbreak repeatedly.The whole world has 100,000,000 6 thousand ten thousand respiratory tract infection or pneumonia patient approximately, and the investigation report of external several countries points out that the prevalence of childrens respiratory tract infection is 0.5%～7.4%, and the prevalence of adult's respiratory tract infection is 1.1%～9.8%.The prevalence of China's respiratory tract infection according to some areas investigation, is about 0.8%～2.4%, report also arranged up to 5.67%.Respiratory infection diseases can occur in any age, and adult men and women sickness rate is roughly similar.Along with improving constantly of industrialization degree and since atmospheric pollution increase the weight of with the development of chemical engineering industry etc., the sickness rate of respiratory system has growth trend gradually.
Though western medicine and medical practitioners is rapider to the treatment drug effect performance of respiratory system disease, be easy to make the rapid relief of symptoms of acute attack stage patient, still " only take stopgap measures, do not effect a permanent cure ", to the effective prevention of recurrence of catabasis patient, so effect is undesirable and have certain toxicity.The traditional Chinese medical science thinks that respiratory system disease takes place mostly to be to be lied prostrate in lung by retained phlegm, is added with inducements such as exopathogen invasion and attack, improper diet, disorder of emotion and draws and touch, and stage of attack, the catabasis was based on deficiency in origin to mark reality.Etiology and pathogenesis has and for retained phlegm in volt, phlegm retention stays volt at two: one, forms the nest mortar, hides in interior, and idol has the criminal of seven emotions, the wound of interior drink, or its flesh table of wind and cold bundle in season is arranged outward; Two lose emptyly for healthy energy, defend aerial root in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, nourish in middle Jiao, develop in the part of the body cavity above the diaphragm housing the heart and lungs, and a certain dirty functions decay that lung spleen kidney three is dirty, it is empty all can to cause healthy energy to be lost, so that a little less than exterior deficiency defends, thereby very easily invaded by exopathogen.In the modern society, aged tendency of population becomes clear day by day, with age growth and life and work pressure, and the ill crowd's showed increased of respiratory system.Treatment or the like product that plays health-care effect are injection or oral drugs mostly, and it is long to take the course of treatment, absorb slowly, can cause other disease.Carry inconvenience simultaneously, need water delivery service when taking, be worth higherly, some specific crowd is had unfavorable factor.
Summary of the invention
The invention provides a kind of Chinese medicine spray for the treatment of pneumonia and upper respiratory tract infection, on the basis of traditional medicine,, adopt that modern processing method is refining to form in conjunction with clinical experience for many years.The present invention adopts different extraction ways to extract its active ingredient to the abundant science compatibility of the various effective ingredient of raw material medicine, and spray is made in the sucking filtration packing, oral cavity, nasal cavity are directly sprayed cloth, absorb by respiratory mucosa, drug effect is remarkable, thorough treatment not repeatedly, and has no side effect.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine spray for the treatment of pneumonia and upper respiratory tract infection, various raw materials in part by weight ratios are: 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Phragmitiss, 10～20 parts of Radix Adenophorae (Radix Glehniae), 10～20 parts in Semen Persicae, 10～20 parts of Folium Eriobotryaes, 10～20 parts of Fructus Trichosanthis, 10～20 parts of Flos Farfaraees, 10～20 parts of Rhizoma Belamcandae, 10～20 parts of Semen Lepidii (Semen Descurainiae)s, 10～20 parts in Herba Ephedrae, 10～20 parts of Herba Houttuyniae, 10～20 parts of Herba Taraxacis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Asteriss, 10～20 parts of Radix Platycodoniss, 10～20 parts of Radix Salviae Miltiorrhizaes.
The Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection, various raw materials in part by weight ratios can also be 10～15 parts of Radix Scutellariaes, 10～15 parts of Rhizoma Phragmitiss, 10～15 parts of Radix Adenophorae (Radix Glehniae), 10～15 parts in Semen Persicae, 10～15 parts of Folium Eriobotryaes, 15～20 parts of Fructus Trichosanthis, 15～20 parts of Flos Farfaraees, 15～20 parts of Rhizoma Belamcandae, 15～20 parts of Semen Lepidii (Semen Descurainiae)s, 15～20 parts in Herba Ephedrae, 15～20 parts of Herba Houttuyniae, 15～20 parts of Herba Taraxacis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Asteriss, 10～20 parts of Radix Platycodoniss, 10～20 parts of Radix Salviae Miltiorrhizaes.
The Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection, various raw materials in part by weight are than also being 15～20 parts of Radix Scutellariaes, 15～20 parts of Rhizoma Phragmitiss, 15～20 parts of Radix Adenophorae (Radix Glehniae), 15～20 parts in Semen Persicae, 15～20 parts of Folium Eriobotryaes, 15～20 parts of Fructus Trichosanthis, 10～15 parts of Flos Farfaraees, 10～15 parts of Rhizoma Belamcandae, 10～15 parts of Semen Lepidii (Semen Descurainiae)s, 10～15 parts in Herba Ephedrae, 10～15 parts of Herba Houttuyniae, 10～15 parts of Herba Taraxacis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Asteriss, 10～20 parts of Radix Platycodoniss, 10～20 parts of Radix Salviae Miltiorrhizaes.
The Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection, various raw materials in part by weight are than being 10～15 parts of Radix Scutellariaes, 10～15 parts of Rhizoma Phragmitiss again, 10～15 parts of Radix Adenophorae (Radix Glehniae), 10～15 parts in Semen Persicae, 10～15 parts of Folium Eriobotryaes, 10～15 parts of Fructus Trichosanthis, 10～20 parts of Flos Farfaraees, 10～20 parts of Rhizoma Belamcandae, 10～20 parts of Semen Lepidii (Semen Descurainiae)s, 10～20 parts in Herba Ephedrae, 10～15 parts of Herba Houttuyniae, 10～15 parts of Herba Taraxacis, 10～15 parts of Indigo Naturaliss, 10～15 parts of Radix Asteriss, 10～15 parts of Radix Platycodoniss, 10～15 parts of Radix Salviae Miltiorrhizaes.
The Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection, its preparation method can may further comprise the steps:
(1) get Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, Rhizoma Phragmitis with vapor distillation 60～180 minutes according to described raw materials in part by weight ratio, it is standby to collect 1～1.5 times of distillate of aforementioned four kinds of raw material weights;
(2) boil twice than 5～10 times the decocting of getting Radix Scutellariae, Radix Adenophorae (Radix Glehniae), Semen Persicae, Fructus Trichosanthis, Flos Farfarae, Rhizoma Belamcandae, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Indigo Naturalis, Radix Asteris, Radix Platycodonis, Radix Salviae Miltiorrhizae, adding aforementioned 12 kinds of raw material total amounts according to described raw materials in part by weight, gradation is filtered, merging filtrate, and be concentrated into the clear paste of 40～60 ℃ of following relative densities 1.45～1.60, put cold;
(3) add the distillate of collecting in the step (1), other adds 5% sodium bicarbonate adjusting pH value to 6.6～7.4;
(4) add 95% ethanol and make the alcohol amount that contains of filtrate reach 70%, stir, placed 12～16 hours, supernatant is got in filtration.
The preparation method of the Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection may further include following steps:
(5) filter, mixing, vacuum filtration, with the medicinal liquid packing, sterilization.
The step (2) of the preparation method of the Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection can also for:
(2) boiled two hours than 6～10 times decocting getting Radix Scutellariae, Radix Adenophorae (Radix Glehniae), Semen Persicae, Fructus Trichosanthis, Flos Farfarae, Rhizoma Belamcandae, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Indigo Naturalis, Radix Asteris, Radix Platycodonis, Radix Salviae Miltiorrhizae, the aforementioned 12 kinds of raw material total amounts of adding according to described raw materials in part by weight, obtain filtrate (a); 3～8 times the decocting that adds for the second time aforementioned 12 kinds of raw material total amounts boiled one hour, obtained filtrate (b), the merging filtrate (a) and (b), filter, concentrate then concentrated solution (c), concentrated solution (c) is concentrated into the clear paste of 40～60 ℃ of following relative densities 1.45～1.60, put cold.
The step (2) of the preparation method of the Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection also can for:
(2) boiled three hours than 6～10 times decocting getting Radix Scutellariae, Radix Adenophorae (Radix Glehniae), Semen Persicae, Fructus Trichosanthis, Flos Farfarae, Rhizoma Belamcandae, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Indigo Naturalis, Radix Asteris, Radix Platycodonis, Radix Salviae Miltiorrhizae, the aforementioned 12 kinds of raw material total amounts of adding according to described raw materials in part by weight, obtain filtrate (a); 3～8 times the decocting that adds for the second time aforementioned 12 kinds of raw material total amounts boiled two hours, obtained filtrate (b), the merging filtrate (a) and (b), filter, concentrate then concentrated solution (c), concentrated solution (c) is concentrated into the clear paste of 40～60 ℃ of following relative densities 1.45～1.60, put cold.
The step (1) of the preparation method of the Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection also can for:
(1) get Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, Rhizoma Phragmitis with vapor distillation 60～180 minutes according to described raw materials in part by weight ratio, it is standby to collect 1～1.5 times of distillate of aforementioned four kinds of raw material weights; Stir evenly distillate, add the precipitant Pulvis Talci in the process that stirs, its consumption is 2/10000ths to 3/10000ths of Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, four kinds of raw material total amounts of Rhizoma Phragmitis.
In the step (2) of the preparation method of the Chinese medicine spray of described treatment pneumonia and upper respiratory tract infection, may further include: spissated clear paste put cold after, add the step of the one thousandth times benzyl alcohol antiseptic of the one thousandth times tween 80 solubilizing agent of described 12 kinds of raw material total amounts and described 12 kinds of raw material total amounts.
Compared with the prior art, the present invention has convenient drug administration, treatment and anti-respond well in advance, advantage such as medicament is easy to make, and is with low cost.The present invention adopts the Chinese crude drug with different drug effects, the science of carrying out compatibility, adopt different extraction ways to extract its active ingredient, spray is made in the sucking filtration packing, oral cavity, nasal cavity are directly sprayed cloth, absorb by respiratory mucosa, the granule medicine that is inhaled into has certain killing action to the pathogenic bacteria that enters lung.Drug effect of the present invention is remarkable, has reached ideal therapeutic effect, has no side effect, and is easy to use, and healing time is short, cures the back and is difficult for recurrence.Preparation method technology of the present invention is simple, and medicine material is cheap, and good effect is social and good in economic efficiency.
The specific embodiment
The present invention adopt have clearing away damp-heat, the Radix Scutellariae of the infantile malnutrition with fever that disappears, Rhizoma Phragmitis alleviate patient symptom, drug efficacy study shows that Radix Scutellariae iridoid constituents can reduce inflammatory mediator and discharge, suppress the chemotactic activity of inflammatory mediator to inflammatory cell, alleviate airway inflammation, suppress bronchoconstriction, improve pulmonary dynamic compliance; The Androsin of phenolic glycoside class can suppress the abnormal former bronchial obstruction that causes with platelet activating factor in the Cavia porcellus body; Also have effects such as anti-inflammation, antioxidation in addition.Drug efficacy study shows that Rhizoma Phragmitis can improve neuroendocrine function simultaneously, regulates body's immunity, improves the human body energy metabolism it is restored balance, and improves people's whole resistivity.Clearing away heat and eliminating dampness of the present invention, harmonizing the functional activities of vital QI, treating both the principal and secondary aspects of a disease, power is specially imitated good.Chinese medical spray medicament of the present invention makes things convenient for patient, pharmaceutical manufacturer conscientiously, overcomes because application method falls behind preparation difficulty, drawbacks such as the unsuitable conventional outfit of oral decoction simultaneously.
The raw material that the present invention treats the Chinese medicine spray of pneumonia and upper respiratory tract infection contains following composition:
Radix Scutellariae: hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement." medicine origin ": Radix Scutellariae, be in harmony damp and hot in the lung, swollen red in the hot order in the treatment, contain on the blood stasis ridge, the medicine that must use.Letting out in the lung fire ascending abnormally to the upper in every last, mend wing cold never foot all of a sudden, is to grow its change source." curing mainly secret formula " cloud, it is with having nine: eliminating the pathogens from the lung is through heat, and one also; Xia Yuexu usefulness, two also; The part of the body cavity above the diaphragm housing the heart and lungs and skin phoenix heat, three also: go all heat, four also; Married woman puerperal, sun is moved back in foster resistance, and five also; Profit is gas in the heart, and six also; Disappear every last expectorant, seven also; It is wet to remove part of the body cavity above the diaphragm housing the heart and lungs heat and spleen, and eight also; Antiabortive, nine also.Single system, two is made, is not made, and divides upper, middle and lower also.Wine is fried up, Your Majesty portion hematocele, and non-this can not remove, the lung being apt to suffer from adverse rising of QI, anxious food bitter flavor having purgating effect is just being called this also.
Rhizoma Phragmitis: sweet, cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Be used for the calentura excessive thirst, the gastric heat sound of vomiting of vomitting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis one medicine is mainly used in following two aspects clinically, can clearing away lung-heat and the evacuation of pus of eliminating the phlegm, and again can clearing away stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid.Though its attribute is cold, slightly sweet flavor and power is used the lung heat clearing stomach can only be as auxiliary medicine.But, it has an advantage, and promptly property is not grown greasyly, promotes the production of body fluid and does not love heresy, and all epidemic febrile disease deep loves are defended, gas, or after the calentura if any the thirsty syndrome of impairment of body fluid, all can use.
Radix Adenophorae (Radix Glehniae): the abnormal smells from the patient hardship, be slightly cold, nontoxic.Cure mainly the frightened gas of accumulation of blood, remove cold and heat, invigorating middle warmer, lung benefiting gas.Stagnation of pathogenic heat pathogen headache, pathogenic heat between skin, settling five organs.Obey sharp people for a long time.Main dizziness pain, QI invigorating, longue meat.The floating wind of peeling skin is controlled Chang Yumian, nourishing the liver gas, a surname's the five internal organs pathogenic wind.Tonify deficiency, spasmolytic is tired of beneficial cardiopulmonary, evacuation of pus, detumescence poison.The lung heat clearing owner of the house where a fire started coughs consumptive lung disease.Li Shizhen (1518-1593 A.D.) is said: Radix Adenophorae (Radix Glehniae) is sweet light and cold, and its body is gently empty, and specially tonifying the lung gas, thereby strengthening the spleen, kidney are so suitable gold can be subjected to fiery gram person.
Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for amenorrhea, dysmenorrhea, abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation." medication heart method ": Semen Persicae, bitter to let out stagnant blood, sweet with tissue regeneration promoting blood, so blood coagulation must be used.Heat in dehematizing again." detailed outline ": the Semen Persicae promoting the circulation of blood, suitable gross weight point is given birth to and is used; Moisturize and invigorate blood circulation, should soak the sharp parching to brown usefulness of peeling for soup, or Testa Tritici stir-fry together, or charred medicinal herb with its property retained, each is with we." medicine justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and the body profit can be grown dryness of the intestine.If gross weight grinds many usefulness, walk Liver Channel, main broken blood-retention, water, and pain all over month by month, extremity wood numbness, left side hemiplegia, left sufficient patient is relaxed through the promoting the circulation of blood of invigorating blood circulation with it, the merit that eliminating blood stasis to promote regeneration of blood is arranged if few usefulness is mashed in peeling, is gone into large intestine, controlling blood depletion just closes, the dry dyschezia of blood with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.
Folium Eriobotryae: hardship is slightly cold.Attach to the lung and stomach meridians.Clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Be used for the cough due to lung-heat, the QI rising in reverse order dyspnea with rapid respiration, the gastric heat vomiting, dysphoria with smothery sensation is thirsty.
Fructus Trichosanthis: sweet, little hardship, cold.Return lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens is moisturized laxation.Be used for the cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and the blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, constipation.Compendium of Material Medica was rolled up 18 years: Fructus Trichosanthis " lung moistening is dry, pathogenic fire reducing, control that cough, clearing away phlegm are tied, only quenched one's thirst, sharp stool, subduing inflammation sore ".Modern medicine and pharmacology studies have shown that: Fructus Trichosanthis contains unsaturated fatty acid 16.8%, protein 5.46%, and contain 17 seed amino acids, three paste Saponin, 16 kinds of trace element such as multivitamin and calcium, ferrum, zinc, selenium.Fructus Trichosanthis has expansion heart arteria coronaria, increases the coronary flow effect; Acute myocardial ischemia there is significant protective effect; Can improve body immune function.
Flos Farfarae: sweet, hardship, cold.Go into lung, the heart two warps.Heat-clearing and toxic substances removing, removing heat from the lung and dissipating phlegm.Be used for diseases such as ulcer sores, erysipelas, innominate toxic swelling, the redness of having sore throat, worm venom.Be used for cough due to lung-heat, asthma, rough, expectorant is yellow and thick, be difficult for bringing up, the yellow fur floating and rapid pulse.Amplification on Canon of Materia Medica carry " Flos Farfarae, during the spring, people or adopt with for vegetables." coltsfoot tender leaf handle and tender colored tongue contain protein, fat.Carbohydrate, multivitamin and several mineral materials.The coltsfoot property and flavor of peppery and warm has the effect of nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Control cough with dyspnea and pant, sore throat etc." Mingyi Bielu " carries and " leads and quench one's thirst asthmoid respiration." " Japan hanako materia medica " carry " relieving restlessness, it is bad to mend labor, stopping coughing and removing phlegm, pulmonary fistula is spitted blood, the palpitation with fear of having a guilty conscience washes that liver makes eye bright and apoplexy for profit cardiopulmonary, beneficial the five internal organs ".
Rhizoma Belamcandae: hardship, cold.Go into lung, Liver Channel.Heat-clearing and toxic substances removing, throat, expectorant saliva.Be used to experience wind heat, or expectorant heat is stopped up the diseases such as laryngopharynx swelling and pain due to containing.Also be used for diseases such as accumulation and obstruction of sputum, cough and asthma.Rhizoma Belamcandae clearing away lung-heat and expectorant saliva, with controlling the cough phlegm dyspnea, normal and Herba Ephedrae, Radix Asteris, Flos Farfarae fit applications.
Semen Lepidii (Semen Descurainiae): property Great Cold, acrid in the mouth, hardship.Return lung, urinary bladder channel.Eliminating pathogen from the lung for relieving asthma, line water detumescence.Be used for sputum stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down for sleeping in, ascites pleural fluid swollen, dysuria." Bencao Jingshu ": Semen Lepidii, be the positive medicine of meridian of Hand-TAI YIN, so Zhong Jing eliminating the pathogens from the lung soup is used it, bright, the meridian of Foot-TAI YANG of sun of also starting with.A lung gold, main fur, bladder belongs to water, hides body fluid, and then bladder is with here for obstruction of lung-QI, and key closes that then lower orifices are obstructed on the example, and lower orifices are obstructed, and then water is wet overflows for dyspnea with fullness of the chest, for swelling, for gathering all diease occurrences.Hot can loosing, hardship can be let out, and descending the relieving oedema or abdominal distension through diuresis or purgation of heavy cloudy energy in Great Cold is so can treat " herbal classic " all diseases of leading." book on Chinese herbal medicine is through hundred kinds of records ": Semen Lepidii is lubricious and fragrant, special eliminating the pathogens from the lung gas, and lung such as water source are so the energy eliminating the pathogens from the lung can removing water retention by purgation.All cold and heat that gather are from the aqueous vapor person that has come, this medicine master it.Rushing down the therefrom burnt beginning of Radix Et Rhizoma Rhei, rushing down from the part of the body cavity above the diaphragm housing the heart and lungs of Semen Lepidii begun, thus CHENGQI TANG Radix Et Rhizoma Rhei in the treatise on Febrile Diseases, and sunken chest soup is with Semen Lepidii also.
Herba Ephedrae: hot, little hardship, temperature.Return lung, urinary bladder channel.The diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Be used for anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema; Bronchial asthma.Honey Herba Ephedrae nourishing the lung to arrest cough is used for showing disease more and separates asthma and cough.Herba Ephedrae and has tangible depressed lung-energy dispersing effect except diaphoresis with drugs pungent in flavor and warm in nature, the cold expelling that induces sweat.Every wind and cold invades outward, a hair key bundle closes and cause lung qi and must not declare logical diseases caused by exogenous pathogenic factor to breath with cough, all available Herba Ephedrae treatment.Even exterior syndrome is separated, but still breath with cough, can also continue at this moment can use Herba Ephedrae (processed) instead with the Herba Ephedrae treatment.The effectiveness of Herba Ephedrae relieving the exterior syndrome by diaphoresis is big, and Herba Ephedrae (processed) diaphoresis power is little and effect antiasthmatic-antitussive is better.The patient who breathes with cough, as occur lung-heat the card marquis (the expectorant Huang is thick, the dry dry pharynx of larynx, mouth and nose gas heat, meet heat then breath with cough increase the weight of, yellow fur, rapid pulse etc.), then need add Radix Scutellariae etc., relieving asthma with clearing away lung-heat.
Herba Houttuyniae: suffering is slightly cold.Return lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.Modern medicine study shows that Herba Houttuyniae has the resisting pathogenic microbes effect, suppresses staphylococcus aureus, hemophilus influenza, Diplococcus pneumoniae.Diuresis makes telangiectasis, and renal blood flow increasing and secretion of urine are so also be used for the puckery pain of the pollakiuria of urinary tract infection.The enhance immunity systemic effect improves the leukocytic phagocytosis of chronic tracheitis patient.Antitumor action improves the CAMP in the cancerous cell and suppresses ehrlich carcinoma." carrying out the rock book on Chinese herbal medicine ": the vexed unrest of great order heatstroke latent heat, syncope." the southern regions of the Yunnan Province book on Chinese herbal medicine ": control lung abscess cough band pus and blood, expectorant has stench, and the large intestine pyretic toxicity is treated hemorrhoid." classification medical herbs ": control five types of stranguria, consumer edema goes food stagnation, and a little less than the tonify deficiency, expansion disappears." south of the Five Ridges gather medicinal herbs record ": leaf: apply vicious large carbuncle(disease), can sterilize; Decoction energy remuval of damp and hot is controlled dysentery.
Herba Taraxaci: sweet, little hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Sweet cold removing summer-heat, bitter with using pungent drugs for dispersion and bitter drugs for purgation, the special removing toxic substances and promoting subsidence of swelling of merit is for controlling the acute mastitis key medicine.Have the merit of dampness removing concurrently.Heat-clearing and toxic substances removing can be used for pyretic toxicity card, kind especially removing heat from the liver, treatment liver-heat conjunctival congestion and swelling pain, and multiple infection, purulent disease.Eliminating carbuncle eliminating stagnation treatment pyretic toxicity is stopped up the carbuncle sore tumefacting virus of tying due to the muscle, hyperpyrexia.Acute mastitis there is good effect, energy detoxicating and resolving stagnation of pathogens lactogenesis, oral administration or external application are often joined Flos Lonicerae and are equal to usefulness.Also can join Radix Et Rhizoma Rhei, Cortex Moutan treatment acute appendicitis in addition.Herba Taraxaci is a Chinese medicine commonly used simply, and its medical value is loaded various medical books early.Its all herbal medicine contains compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.The flat sweet and slightly bitter taste of property.But heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Significant galgctogogue action is arranged, and the treatment mastitis are very effective.It is oral no matter to fry in shallow oil juice, or the smash to mud external application, and effect is all arranged.In addition, Herba Taraxaci also has diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting, aid digestion, increases appetite, and the treatment gastric and duodenal ulcers also can be prevented and treated effects such as cancer, gastric cancer, the esophageal carcinoma and various tumor.
Indigo Naturalis: salty, cold.Heat clearing away, removing heat from blood, detoxifcation.Control the epidemic febrile disease intenseness of heat, macule is spitted blood, is spat blood, pediatric epilepsy scared, and skin ulcer is swollen, erysipelas, snake bite and insect sting." property of medicine opinion ": " sweet in the mouth, flat." " Kaibao Bencao ": " and salty in the mouth, cold, nontoxic." " the medical center bun is wanted ": " hot salty." " book on Chinese herbal medicine is new again ": " and bitter in the mouth, cold in nature, nontoxic." go into liver, lung, stomach warp." Thunder God is concocted the property of medicine and is separated ": " go into liver, spleen two warps." " book on Chinese herbal medicine is just read ": " go into prosperously, can go into lung, stomach again.”
Radix Asteris: nature and flavor are warm in nature, bitter in the mouth, suffering.Hardship, cold.Go into stomach, liver, spleen three warps.Main nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Be used for that abundant expectoration is breathed with cough, new chronic cough is coughed, the chronic cough hemoptysis.
Radix Platycodonis: return lung; The stomach warp.Bitter in the mouth; Hot; The flat lung qi dispersing of property; Eliminate the phlegm; Sore-throat relieving; Evacuation of pus.Cure mainly cough with copious phlegm; Laryngopharynx swelling and pain; The lung abscess vomiting pus; The full hypochondriac pain of born of the same parents; Dysentery stomachache; Uroschesis." Bencao Jingshu ": Radix Platycodonis, see it and lead all diseases, should be arduous sweet flat, tepor is nontoxic.The typhoid fever pathogens agglomerating breast side of body, then pain is as lancination; Evil in middle Jiao, then abdominal distention and borborygmus are faint, hot loose to rise send out, hardship let out sweet and, then heresy separate and gas and, all cards are from moving back.Its main gas person that throbs with fear in terror, heart temper insufficiency of blood then shows this card, in all reinforcing the heart medicines, borrows its power of going up, thinks that ships win the usefulness of carrying, and this assistant makes it duty also." not Lu " sharp the five internal organs the intestines and stomach, the gas person that enriches blood, lid refer to heresy separate then the internal organs the intestines and stomach from and and then vim and vigour are also spontaneous.Remove cold and heat migratory arthralgia, warming middle-JIAO, treatment laryngopharynx pain, diseases due to noxious agents produced by various parasites person down, the merit of the evil detoxifcation tonneau that all looses also, the rapid digestion of food person, rise with it and to carry a yang-energy, make Jiao placed in the middle and do not sink, then yang-energy is long floating in the spleen, and the paddy food is from disappearing.Zhen Quan is in order to controling the inferior dysentery, and goes lung-heat tachypnea person, rises dying also of heat radiation heresy.Solar corona is warded off pestilence, the lung abscess evacuation of pus in order to remove heresy; Clean Gu is used in order to key and is removed pulmonary's wind heat, the clear sharp head, and pharynx chest and diaphragm stagnate gas and pain are removed nasal obstruction person, and the merit of going into lung exploitation reconciliation is also.
Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.
Embodiment:
The Chinese medicine spray of present embodiment treatment pneumonia and upper respiratory tract infection, various raw materials in part by weight are: Radix Scutellariae 15g, Rhizoma Phragmitis 15g, Radix Adenophorae (Radix Glehniae) 15g, Semen Persicae 15g, Folium Eriobotryae 15g, Fructus Trichosanthis 20g, Flos Farfarae 20g, Rhizoma Belamcandae 20g, Semen Lepidii (Semen Descurainiae) 20g, Herba Ephedrae 20g, Herba Houttuyniae 20g, Herba Taraxaci 20g, Indigo Naturalis 20g, Radix Asteris 20g, Radix Platycodonis 20g, Radix Salviae Miltiorrhizae 20g.
Preparation method may further comprise the steps:
(1) get Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, Rhizoma Phragmitis with vapor distillation 140 minutes according to the weight of described raw material, it is standby to collect 1.2 times of distillates of aforementioned four kinds of raw material weights; Stir evenly distillate, add the precipitant Pulvis Talci in the process that stirs, its consumption is 2/10000ths of Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, four kinds of raw material total amounts of Rhizoma Phragmitis;
(2) 8 times decocting getting Radix Scutellariae, Radix Adenophorae (Radix Glehniae), Semen Persicae, Fructus Trichosanthis, Flos Farfarae, Rhizoma Belamcandae, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Indigo Naturalis, Radix Asteris, Radix Platycodonis, Radix Salviae Miltiorrhizae, the aforementioned 12 kinds of raw material total amounts of adding according to the weight of described raw material boiled two hours, obtained filtrate (a); 5 times the decocting that adds for the second time aforementioned 12 kinds of raw material total amounts boiled one hour, obtained filtrate (b), the merging filtrate (a) and (b), filter, concentrate then concentrated solution (c), concentrated solution (c) is concentrated into the clear paste of 40～60 ℃ of following relative densities 1.45～1.60, put cold; Spissated clear paste put cold after, add the one thousandth times tween 80 solubilizing agent of described 12 kinds of raw material total amounts and the one thousandth times benzyl alcohol antiseptic of described 12 kinds of raw material total amounts;
(3) add the distillate of collecting in the step (1), other adds 5% sodium bicarbonate adjusting pH value to 6.6～7.4;
(4) add 95% ethanol and make the alcohol amount that contains of filtrate reach 70%, stir, placed 12～16 hours, supernatant is got in filtration.
(5) filter, mixing, vacuum filtration, with the medicinal liquid packing, sterilization.
Case is selected and grouping: through the pneumonia or upper respiratory tract infection patient 67 examples of clinical definite, and male 35 examples, women 32 examples at 15～73 years old age, are divided into treatment group (33 example) and matched group (34 example) at random.The treatment group gives 20 milliliters of sprays of the present invention, in the medical vaporizer of packing into except that conventional oral medication, spray into oral cavity, nasal cavity and nasopharynx part every day 4～6 times, push 3～5 times at every turn, make spray into liquid in the oral cavity or nasopharynx part kept 2～4 minutes, 5 is a course of treatment; The conventional oral administration treatment of matched group.
Observation of curative effect: measuring lung function index before and after the treatment is 1s FEC (FEV1) and 1s FEC/expiration vital capacity (FEV1/FVC); Curative effect judging standard is breathed the standard that sick association of system formulates according to Chinese Medical Association.
Result of the test: the patient who is diagnosed as pneumonia or upper respiratory tract infection, inhale spray of the present invention in the bottleneck throat spray, the standard that disappears in 3 days after medication with symptom is judged to effectively, the 4th day symptom still do not disappear for invalid after the medication, and headache, sneeze, throat pain or symptom medications such as hoarseness and systemic pain all took a turn for the better after 3 days.
Two groups of patients all have clear improvement in treatment back lung, respiratory tract function, but the improvement of treatment group obviously is better than matched group; And the effective percentage of treatment group is apparently higher than matched group (P＜0.05), and wherein clinical effective rate treatment group is 100%, and matched group is 69.7%.
Two groups of patients clinical curative effects
Group example digital display is imitated the invalid effective percentage (%) that takes a turn for the better
Treatment organizes 34 22 12 0 100
Matched group 33 12 11 10 69.7
Lung function parameter variation before and after two groups of patient-(X ± s)
Group time FEV1 (L) FEV1/FVC (%)
Treatment group treatment preceding 1.41 ± 0.53 52.05 ± 10.17
Treatment back 2.64 ± 0.79 80.41 ± 10.09
Treatment of control group preceding 1.43 ± 0.38 53.67 ± 10.37
Treatment back 1.86 ± 0.43 66.78 ± 10.04
Spray convenient drug administration of the present invention, treatment and anti-respond well in advance, medicament is easy to make, and is with low cost, adopts the Chinese crude drug with different drug effects, the science of carrying out compatibility, adopt different extraction ways to extract its active ingredient, spray is made in the sucking filtration packing, and oral cavity, nasal cavity are directly sprayed cloth, absorb by respiratory mucosa, the granule medicine that is inhaled into has certain killing action to the pathogenic bacteria that enters lung.Drug effect of the present invention is remarkable, has reached ideal therapeutic effect, has no side effect, and is easy to use, and healing time is short, cures the back and is difficult for recurrence.Preparation method technology of the present invention is simple, and medicine material is cheap, and good effect is social and good in economic efficiency.
Claims (8)
1. a Chinese medicine spray for the treatment of pneumonia and upper respiratory tract infection is characterized in that, various raw materials in part by weight ratios are: 10～20 parts of Radix Scutellariaes, 10～20 parts of Rhizoma Phragmitiss, 10～20 parts of Radix Adenophorae (Radix Glehniae), 10～20 parts in Semen Persicae, 10～20 parts of Folium Eriobotryaes, 10～20 parts of Fructus Trichosanthis, 10～20 parts of Flos Farfaraees, 10～20 parts of Rhizoma Belamcandae, 10～20 parts of Semen Lepidii (Semen Descurainiae)s, 10～20 parts in Herba Ephedrae, 10～20 parts of Herba Houttuyniae, 10～20 parts of Herba Taraxacis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Asteriss, 10～20 parts of Radix Platycodoniss, 10～20 parts of Radix Salviae Miltiorrhizaes.
2. according to the Chinese medicine spray of described treatment pneumonia of claim 1 and upper respiratory tract infection, it is characterized in that, various raw materials in part by weight ratios are: 10～15 parts of Radix Scutellariaes, 10～15 parts of Rhizoma Phragmitiss, 10～15 parts of Radix Adenophorae (Radix Glehniae), 10～15 parts in Semen Persicae, 10～15 parts of Folium Eriobotryaes, 15～20 parts of Fructus Trichosanthis, 15～20 parts of Flos Farfaraees, 15～20 parts of Rhizoma Belamcandae, 15～20 parts of Semen Lepidii (Semen Descurainiae)s, 15～20 parts in Herba Ephedrae, 15～20 parts of Herba Houttuyniae, 15～20 parts of Herba Taraxacis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Asteriss, 10～20 parts of Radix Platycodoniss, 10～20 parts of Radix Salviae Miltiorrhizaes.
3. according to the Chinese medicine spray of described treatment pneumonia of claim 1 and upper respiratory tract infection, it is characterized in that, various raw materials in part by weight ratios are: 15～20 parts of Radix Scutellariaes, 15～20 parts of Rhizoma Phragmitiss, 15～20 parts of Radix Adenophorae (Radix Glehniae), 15～20 parts in Semen Persicae, 15～20 parts of Folium Eriobotryaes, 15～20 parts of Fructus Trichosanthis, 10～15 parts of Flos Farfaraees, 10～15 parts of Rhizoma Belamcandae, 10～15 parts of Semen Lepidii (Semen Descurainiae)s, 10～15 parts in Herba Ephedrae, 10～15 parts of Herba Houttuyniae, 10～15 parts of Herba Taraxacis, 10～20 parts of Indigo Naturaliss, 10～20 parts of Radix Asteriss, 10～20 parts of Radix Platycodoniss, 10～20 parts of Radix Salviae Miltiorrhizaes.
4. according to the Chinese medicine spray of described treatment pneumonia of claim 1 and upper respiratory tract infection, it is characterized in that, various raw materials in part by weight ratios are: 10～15 parts of Radix Scutellariaes, 10～15 parts of Rhizoma Phragmitiss, 10～15 parts of Radix Adenophorae (Radix Glehniae), 10～15 parts in Semen Persicae, 10～15 parts of Folium Eriobotryaes, 10～15 parts of Fructus Trichosanthis, 10～20 parts of Flos Farfaraees, 10～20 parts of Rhizoma Belamcandae, 10～20 parts of Semen Lepidii (Semen Descurainiae)s, 10～20 parts in Herba Ephedrae, 10～15 parts of Herba Houttuyniae, 10～15 parts of Herba Taraxacis, 10～15 parts of Indigo Naturaliss, 10～15 parts of Radix Asteriss, 10～15 parts of Radix Platycodoniss, 10～15 parts of Radix Salviae Miltiorrhizaes.
5. according to the Chinese medicine spray of each described treatment pneumonia and upper respiratory tract infection in the claim 1～4, it is characterized in that its preparation method may further comprise the steps:
(1) get Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, Rhizoma Phragmitis with vapor distillation 60～180 minutes according to described raw materials in part by weight ratio, it is standby to collect 1～1.5 times of distillate of aforementioned four kinds of raw material weights;
(2) get Radix Scutellariae, Radix Adenophorae (Radix Glehniae), Semen Persicae, Fructus Trichosanthis, Flos Farfarae, Rhizoma Belamcandae, Semen Lepidii (Semen Descurainiae), Herba Ephedrae, Indigo Naturalis, Radix Asteris, Radix Platycodonis and Radix Salviae Miltiorrhizae according to described raw materials in part by weight ratio, 5～10 times the decocting that adds aforementioned 12 kinds of raw material total amounts boils twice, gradation is filtered, merging filtrate, and be concentrated into the clear paste of 40～60 ℃ of following relative densities 1.45～1.60, put cold;
(3) add the distillate of collecting in the step (1), other adds 5% sodium bicarbonate adjusting pH value to 6.6～7.4;
(4) add 95% ethanol and make the alcohol amount that contains of filtrate reach 70%, stir, placed 12～16 hours, supernatant is got in filtration.
6. according to the Chinese medicine spray of described treatment pneumonia of claim 5 and upper respiratory tract infection, it is characterized in that described preparation method further may further comprise the steps:
(5) filter, mixing, vacuum filtration, with the medicinal liquid packing, sterilization.
7. according to the Chinese medicine spray of described treatment pneumonia of claim 5 and upper respiratory tract infection, it is characterized in that the step of described preparation method (1) is:
(1) get Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, Rhizoma Phragmitis with vapor distillation 60～180 minutes according to described raw materials in part by weight ratio, it is standby to collect 1～1.5 times of distillate of aforementioned four kinds of raw material weights; Stir evenly distillate, add the precipitant Pulvis Talci in the process that stirs, its consumption is 2/10000ths to 3/10000ths of Herba Taraxaci, Folium Eriobotryae, Herba Houttuyniae, four kinds of raw material total amounts of Rhizoma Phragmitis.
8. according to the Chinese medicine spray of described treatment pneumonia of claim 5 and upper respiratory tract infection, it is characterized in that, in the step of described preparation method (2), further comprise: spissated clear paste put cold after, add the step of the one thousandth times benzyl alcohol antiseptic of the one thousandth times tween 80 solubilizing agent of described 12 kinds of raw material total amounts and described 12 kinds of raw material total amounts.
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| CN1323673C (en) * | 2004-03-30 | 2007-07-04 | 沈惠明 | Medicinal formulation for treating upper respiratory track infection and its design method |
| CN101143176A (en) * | 2007-08-25 | 2008-03-19 | 尹克华 | Traditional Chinese medicine for treating lung cancer |
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| CN1323673C (en) * | 2004-03-30 | 2007-07-04 | 沈惠明 | Medicinal formulation for treating upper respiratory track infection and its design method |
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