CN104474523A

CN104474523A - Medicine for treating phlegm-heat accumulated-in-lung type mycoplasma pneumonia and preparation method thereof

Info

Publication number: CN104474523A
Application number: CN201510009849.XA
Authority: CN
Inventors: 江秀爱
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-01-09
Filing date: 2015-01-09
Publication date: 2015-04-01

Abstract

The invention discloses medicine for treating phlegm-heat accumulated-in-lung type mycoplasma pneumonia and a preparation method of the medicine. The medicine comprises ginkgo seeds, radix scutellariae, perilla leaves, ginger, liquorice, inula flowers, radix peucedani, herba asari, poria cocos, herba schizonepetae, Tatarian aster roots, mint, radish seeds, houttuynia cordata, mulberry leaves, cyrtomium rhizome, bidens biternata, tangerine peels, raw malt, raw rice sprouts, fistular onion stalks, radix stemonae, dandelion, ligusticum pteridophyllum Franch, ceylon leucas herb, betel pepper leaves and oxygraphis glacialis. The medicine follows the principle of dispelling wind and cold, eliminating phlegm and stopping cough, has the functions of clearing heat, removing toxicity, inducing and descending lung qi, soothing liver, relieving depression, promoting digestion and harmonizing stomach, mainly treats the mycoplasma pneumonia, and is new medicine which is simple in manufacturing process, convenient and easy to manufacture, low in toxic and side effect, convenient to dose, low in cost, definite in curative effect and capable of quickly and thoroughly treating the mycoplasma pneumonia, and the mycoplasma pneumonia is not prone to relapse after patients are cured.

Description

A kind ofly treat medicine of phlegm-heat accumulated in the lung type mycoplasma pneumonia and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating medicine of phlegm-heat accumulated in the lung type mycoplasma pneumonia and preparation method thereof.

Background technology

Mycoplasma pneumonia is the acute respiratory infection companion pneumonia that mycoplasma pneumoniae causes, and is called that, in the pathogen of " primary atypical pneumonia ", mycoplasma pneumoniae is the most common in the past.Can cause popular, account for 10% of various pneumonia, serious mycoplasma pneumonia also can cause death.

Symptom: 2 ~ 3 weeks incubation periods, onset is slow, and about 1/3 case is asymptomatic.Occur with the form of arm-bronchitis, pneumonia, ear drum membrane inflammation etc., and the heaviest with pneumonia.Morbidity just has weak, headache, pharyngalgia, feels cold, generate heat, muscular soreness, loss of appetite, Nausea and vomiting etc., has a headache remarkable.Heating height differs, can up to 39 DEG C.There is obvious respiratory symptom after 2 ~ 3 days, as paroxysmal irritable cough, cough a small amount of sticky expectorant or mucopurulent sputum, sometimes sputum mixed with blood.Generate heat sustainable 2 ~ 3 weeks.Temperature is recovered still can lose cough normally, pain under companion's breastbone, but without chest pain.Mild nasal congestion, watery nasal discharge are shown in health check-up, and pharynx moderate is congested.Ear drum membrane often has hyperemia, and about 15% has myringitis.Lymphonodi cervicales can enlargement.Minority case has maculopapule, erythema or herpes labialis.The general Non Apparent Abnormality sign of chest, about half audible dryness or moist rale, there is a small amount of hydrothorax in about 10% ~ 15% case.The state of an illness is general comparatively light, sometimes can weigh, but seldom dead.Generate heat 3 days to 2 weeks, cough can extend to about 6 weeks.Have 10% recurrence, pneumonia sees same leaf or same leaf, and the cold agglutination titer of a few patients erythrocyte is tired more than 1: 500./ suitable intravascular hemolysis can be had, when haemolysis often sees and brings down a fever, or betide when suffering from cold.Only a few case can occur together nervus centralis symptom, and such as meningitis, meningoencephalitis, mostly occur radiculitis, even Mental Subnormality etc.Hemorrhagic ear drum membrane inflammation, gastroenteritis, arthritis, thrombocytopenic purpura, hemolytic anemia, pericarditis, myocarditis, hepatitis are also found.

Pathogenesis: mycoplasma pneumoniae is between antibacterial and virus, the minimum microorganism that can live on one's own life, size is 200nm.Acellular wall, only by the cell membrane be made up of 3 tunics, often obscure mutually with the l type of antibacterial, both bacterium colonies are similar, can grow and schizogamy, containing rna and dna, through metabolism produce power, to antibiotic sensitive in acellular culture medium.Mycoplasma is the pathogen of animal various diseases, has found 8 types at present, wherein only has mycoplasma pneumoniae certainly to cause a disease to people, mainly respiratory system disease.Well-grown on the agar culture medium of 20% horse serum and yeast, visible typical in dome-shaped Fructus Mori shape bacterium colony under being incubated at microscope for the first time, transmit fried egg shape after repeatedly going down to posterity.Mycoplasma fermentans glucose, has hemadsorption (hemadsorption) effect, dissolves the erythrocyte of Cavia porcellus, sheep, to tool resistances such as methylene blue, thaliium acetate, penicillins.Finally serological diagnosis need be made.It is by mouth, nasal discharge air-borne transmission, causes and distributes and little popular respiratory tract infection, be mainly seen in Children and teenager, and find now also non-rare in adult, autumn and winter is more.Respiratory tract infection has pharyngitis and bronchitis, and minority involves lung.Mycoplasma pneumonia accounts for more than 1/3 of non-bacterial pneumonia, or 10% of various pneumonia.

Diagnosis: clinical symptoms is as headache, weak, myalgia, nasopharynx pathological changes, cough, chest pain, purulent sputum and bloody sputum, and the performance of pulmonary x line and laboratory inspection such as cold agglutination test etc. help diagnosis.One, medical history, symptom: onset is comparatively slow, and majority is pharyngitis, bronchitic performance, and 10% is pneumonia.Symptom mainly contains shiver with cold, heating, weak, headache, all over the body discomfort, zest dry cough, and with sticky expectorant, purulent sputum, even bloody sputum, severe one can be breathed hard, and has chest pain when play is coughed; Also nauseating, inappetence can be had, vomiting, the Pulmonary hypofuntion such as diarrhoea and arthralgia, myocarditis, pericarditis, hepatitis, peripheral neuritis, meningitis, skin wrinkle pimple.Two, health check-up finds: nasopharynx part and conjunctival congestion, edema, can have cervical lymph node enlargement, erythra; How not obvious chest sign is, and auscultation of lung can have fine rales, occasionally has pleuritic rub and hydrothorax to levy.Three, auxiliary examination: (one) x line rabat is enhanced lung markings, and pulmonary parenchyma can have polymorphic infiltration shape, common with inferior lobe, also can, in mottled, patch shape or evenly confusing shadows.About 1/5 has a small amount of hydrothorax.(2) etiological examination: the separation of mycoplasma pneumoniae, is difficult to extensive use, is helpless to early diagnosis.(3) Serological testing: serum sickness original antibody is tired >1:32, streptococcus mg agglutination test, tire >=1:40 for positive, double more than 4 times are increased and have diagnostic value.Serum indirect test >1:32, indirect fluorescent test >1:66, the anti-mycoplasma pneumoniae igg>1:16 of indirect immunofluorescence, anti-mycoplasma pneumoniae igm>1:8, Avidin elisa, can direct-detection mycoplasma pneumoniae antigen, can result be obtained in 24 hours, all have diagnostic significance.Four, Differential Diagnosis: should differentiate mutually with infiltrative pulmonary tuberculosis, viral pneumonia, bacterial pneumonia etc.

The traditional Chinese medical science is thought, the disease of this class of mycoplasma pneumonia, and it is marked on lung, and base will at kidney.In other words, seem that cough is pulmonary disease, but essence is suffered from a deficiency of the kidney. lung master exhale, the main suction of kidney, lung governing diffusion, kidney governing inspiration.When the state of an illness is hurried, with lung qi dispersing heat clearing away, relieving asthma, eliminating phlegm for controlling, during disease amelioration with the kidney invigorating, improving inspiration by invigorating kidney-QI, benefit essence, foster the spirit of nobility as controlling.Prevention mycoplasma pneumonia the more important thing is dietetic therapy, and dietetic therapy has very high nutritive value, energy enhancing body resistance against diseases, to improving symptom, promoting that rehabilitation has good effect.Chinese medical discrimination: (one) wind and cold visitor table, phlegm-heat accumulated in the lung card clinical manifestation: nasal obstruction watery nasal discharge, headache pharyngalgia, cough is coughed up phlegm, and flat sleeping or nocturnal cough increases the weight of, floating and tense pulse.(2) the exterior and the interior combined pathogens, three burnt all disease clinical manifestations: fever with aversion to cold, head-body-pain, breast gastral cavity is full swollen, bitter taste xerostomia, nausea and vomiting, micro-work of coughing, and tongue fur is white, wiry and frequent pulse.(3) disease involving all three YANG meridians card clinical manifestation: alternate attack of chill and fever, head-body-pain, cough fullness in the chest (logical vexed), thirst and liking drink, stringy and tense pulse number.(4) spleen lung is with sick, external cold internal rheum card clinical manifestation: fever with chills, general pain or non-general pain, cough or cough with asthma, abdominal distention distending pain, floating and tense pulse number.(5) liver lung qi is strongly fragrant, and phlegm-damp does not change card clinical manifestation: fullness in the chest (logical vexed) chest pain, cough pharyngalgia, dizziness headache, nausea of feeling sick, deep and stringy pulse.

Western medical treatment: 1, general treatment respiratory tract isolation, has a rest, supplies enough moisture and nutrition.Symptomatic treatment: avoid with Salicylates in case haemolysis.Generally select and have slowly and the antipyretic analgesic of dauer effect, as to acetyl phenol, carbasalate calcium, rely ammonia than woods, Radix Bupleuri etc., be aided with Physical temperature-lowering during high heat.Preventing phlegm from forming and stopping coughing.Remove nasal secretion, keep respiratory passage unblocked.Aerosolizable suction if desired.2, the clinical first-selected erythromycin 30 ~ 50mg/ (kgd) of antibacterial therapy, points 4 times oral, adult 1.5g/d, and points 3 times oral, 2 ~ 3 weeks courses for the treatment of.Macrolide new drug, as Roxithromycin, gastrointestinal side-effect is few, and body-fluid concentration is high, and cell-penetrating power is strong, long half time, and consumption is little, 5mg ~ 10mg/ (kgd), and points 2 times oral.New drug azithromycin capsule first dose of 10mg/ (kgd), later 5mg/ (kgd), once oral, within 5 days, be a course for the treatment of.Because of long half time, still sustainable 1 week of drug effect after drug withdrawal.Also norfloxacin or each 0.4g of ciprofloxacin is selected, 2 times/d, 5 ~ 7 days courses for the treatment of.Western medicine side effect: gastrointestinal reaction, hepatic injury, allergic drug eruption, medicine heat, central nervous system toxicity, photosensitivity reaction, cardiac toxicity etc.

Chinese herbal medicine be with animal, plant etc. for raw material, there is natural structure and activity, natural green, have very large advantage.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of with expelling wind and cold, preventing phlegm from forming and stopping coughing for principle, hold concurrently with heat-clearing and toxic substances removing, dispersing and lowering lung-QI, dispersing the stagnated live-QI to relieve the stagnation of QI, help digestion stomach function regulating, cures mainly medicine of phlegm-heat accumulated in the lung type mycoplasma pneumonia and preparation method thereof; Formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.Invention has been scientific compatibility, desirable therapeutic effect can be reached, and safety, toxic and side effects is little, and preparation is simple, and can go directly mycoplasma pneumonia stove, and healing time is short, not easily recurs after healing.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of phlegm-heat accumulated in the lung type mycoplasma pneumonia, wherein, described medicine comprises following raw medicinal material: Semen Ginkgo, Radix Scutellariae, Folium Perillae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Flos Inulae, Radix Peucedani, Herba Asari, Poria, Herba Schizonepetae, Radix Asteris, Herba Menthae, Semen Raphani, Herba Houttuyniae, Folium Mori, Rhizoma Osmundae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Exocarpium Citri Rubrum, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Bulbus Allii Fistulosi, the Radix Stemonae, Herba Taraxaci, black Rhizoma Ligustici, Herba leucadis zeylanicae, Folium piperis betlis, duck sole of the foot flower.

Wherein, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 4-7 weight portion, Radix Scutellariae 15-20 weight portion, Folium Perillae 10-15 weight portion, Rhizoma Zingiberis Recens 20-25 weight portion, Radix Glycyrrhizae 25-30 weight portion, Flos Inulae 2-5 weight portion, Radix Peucedani 20-25 weight portion, Herba Asari 3-6 weight portion, Poria 10-20 weight portion, Herba Schizonepetae 15-20 weight portion, Radix Asteris 20-30 weight portion, Herba Menthae 10-20 weight portion, Semen Raphani 10-20 weight portion, Herba Houttuyniae 20-30 weight portion, Folium Mori 15-20 weight portion, Rhizoma Osmundae 4-6 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 weight portion, Exocarpium Citri Rubrum 10-14 weight portion, Fructus Hordei Germinatus 9-13 weight portion, raw Fructus Setariae Germinatus 8-14 weight portion, Bulbus Allii Fistulosi 20-25 weight portion, Radix Stemonae 25-30 weight portion, Herba Taraxaci 20-30 weight portion, black Rhizoma Ligustici 10-14 weight portion, Herba leucadis zeylanicae 15-20 weight portion, Folium piperis betlis 20-25 weight portion and duck sole of the foot flower 14-24 weight portion.

Wherein, also comprise Herba Caryopteridis Terniflorae, Herba leerisae hexandrae, Folium Perillae Frutescentis, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 4-7 weight portion, Radix Scutellariae 15-20 weight portion, Folium Perillae 10-15 weight portion, Rhizoma Zingiberis Recens 20-25 weight portion, Radix Glycyrrhizae 25-30 weight portion, Flos Inulae 2-5 weight portion, Radix Peucedani 20-25 weight portion, Herba Asari 3-6 weight portion, Poria 10-20 weight portion, Herba Schizonepetae 15-20 weight portion, Radix Asteris 20-30 weight portion, Herba Menthae 10-20 weight portion, Semen Raphani 10-20 weight portion, Herba Houttuyniae 20-30 weight portion, Folium Mori 15-20 weight portion, Rhizoma Osmundae 4-6 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 weight portion, Exocarpium Citri Rubrum 10-14 weight portion, Fructus Hordei Germinatus 9-13 weight portion, raw Fructus Setariae Germinatus 8-14 weight portion, Bulbus Allii Fistulosi 20-25 weight portion, Radix Stemonae 25-30 weight portion, Herba Taraxaci 20-30 weight portion, black Rhizoma Ligustici 10-14 weight portion, Herba leucadis zeylanicae 15-20 weight portion, Folium piperis betlis 20-25 weight portion, duck sole of the foot flower 14-24 weight portion, Herba Caryopteridis Terniflorae 10-14 weight portion, Herba leerisae hexandrae 20-25 weight portion and Folium Perillae Frutescentis 10-20 weight portion.

Wherein, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 7 weight portion, Radix Scutellariae 20 weight portion, Folium Perillae 10 weight portion, Rhizoma Zingiberis Recens 25 weight portion, Radix Glycyrrhizae 30 weight portion, Flos Inulae 5 weight portion, Radix Peucedani 25 weight portion, Herba Asari 6 weight portion, Poria 20 weight portion, Herba Schizonepetae 20 weight portion, Radix Asteris 30 weight portion, Herba Menthae 20 weight portion, Semen Raphani 20 weight portion, Herba Houttuyniae 30 weight portion, Folium Mori 20 weight portion, Rhizoma Osmundae 4 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 weight portion, Exocarpium Citri Rubrum 10 weight portion, Fructus Hordei Germinatus 9 weight portion, raw Fructus Setariae Germinatus 14 weight portion, Bulbus Allii Fistulosi 20 weight portion, the Radix Stemonae 30 weight portion, Herba Taraxaci 30 weight portion, black Rhizoma Ligustici 14 weight portion, Herba leucadis zeylanicae 20 weight portion, Folium piperis betlis 25 weight portion and the duck sole of the foot spend 24 weight portions.

Wherein, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 7 weight portion, Radix Scutellariae 20 weight portion, Folium Perillae 10 weight portion, Rhizoma Zingiberis Recens 25 weight portion, Radix Glycyrrhizae 30 weight portion, Flos Inulae 5 weight portion, Radix Peucedani 25 weight portion, Herba Asari 6 weight portion, Poria 20 weight portion, Herba Schizonepetae 20 weight portion, Radix Asteris 30 weight portion, Herba Menthae 20 weight portion, Semen Raphani 20 weight portion, Herba Houttuyniae 30 weight portion, Folium Mori 20 weight portion, Rhizoma Osmundae 4 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 weight portion, Exocarpium Citri Rubrum 10 weight portion, Fructus Hordei Germinatus 9 weight portion, raw Fructus Setariae Germinatus 14 weight portion, Bulbus Allii Fistulosi 20 weight portion, the Radix Stemonae 30 weight portion, Herba Taraxaci 30 weight portion, black Rhizoma Ligustici 14 weight portion, Herba leucadis zeylanicae 20 weight portion, Folium piperis betlis 25 weight portion, the duck sole of the foot spends 24 weight portions, Herba Caryopteridis Terniflorae 14 weight portion, Herba leerisae hexandrae 25 weight portion and Folium Perillae Frutescentis 10 weight portion.

In order to solve the problems of the technologies described above, present invention also offers a kind of preparation method of described medicine, wherein, the dosage form of described medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 6 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 70 ~ 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Wherein, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 80 ~ 90%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.05 ~ 0.1 times of lactose, the starch of 0.1 ~ 0.2 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.001 ~ 0.01 times of magnesium stearate, granulate, tabletting, makes.

Wherein, the dosage form of described medicine is honey refining pill, and its preparation method comprises the following steps:

Step 1: by grind into powder after Semen Ginkgo, Radix Scutellariae and Folium Perillae distillation crystallization;

Step 2: get surplus stock medical material again and add 80-95% soak with ethanol 0.5-1.5 hour of 2-4 times amount, heating extraction 1-2 time, each 0.5-1.0 hour, filter to obtain extracting solution, merge extractive liquid, be the ultrafiltration post ultrafiltration of 38000-84000 again through the molecular weight that dams, ultrafiltration decompression removing ethanol, during simmer down to 80-92 DEG C, relative density is the extractum of 1.03-1.1, becomes component 1;

Step 3: the medicinal residues that step 2 obtains add 1-3 times amount water soaking 1.0-2.0 hour, extracts 1 time, is the extractum of 1.03-1.1, as component 2 by relative density during extracting solution heating under reduced pressure simmer down to 80-90 DEG C for 1.0-1.5 hour;

Step 4: component 1, component 2 are mixed with the powder that step 1 obtains, adds and is twisted into honey refining pill relative to the Mel of mixture 1-2 times amount.

The invention has the beneficial effects as follows: the present invention for principle with expelling wind and cold, preventing phlegm from forming and stopping coughing, holds concurrently with heat-clearing and toxic substances removing, dispersing and lowering lung-QI, dispersing the stagnated live-QI to relieve the stagnation of QI, help digestion stomach function regulating, cures mainly phlegm-heat accumulated in the lung type mycoplasma pneumonia; Formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, and can go directly mycoplasma pneumonia stove, and healing time is short, not easily recurs after healing.

Detailed description of the invention

For the corresponding symptom suffering from the appearance of phlegm-heat accumulated in the lung type mycoplasma pneumonia, the invention provides that one has can conditioning human spleen and stomach function, treatment short treating period, effect is better, residual quantity low while can enhancing immunity and resistivity, medicine of green non-pollution and preparation method thereof.

Wherein medicine comprises following raw medicinal material: Semen Ginkgo, Radix Scutellariae, Folium Perillae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Flos Inulae, Radix Peucedani, Herba Asari, Poria, Herba Schizonepetae, Radix Asteris, Herba Menthae, Semen Raphani, Herba Houttuyniae, Folium Mori, Rhizoma Osmundae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Exocarpium Citri Rubrum, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Bulbus Allii Fistulosi, the Radix Stemonae, Herba Taraxaci, black Rhizoma Ligustici, Herba leucadis zeylanicae, Folium piperis betlis, duck sole of the foot flower.Also comprise Herba Caryopteridis Terniflorae, Herba leerisae hexandrae, Folium Perillae Frutescentis.We's compatibility is reasonable, rigorous, with expelling wind and cold, preventing phlegm from forming and stopping coughing for principle, holds concurrently and treats mycoplasma pneumonia with heat-clearing and toxic substances removing, dispersing and lowering lung-QI, dispersing the stagnated live-QI to relieve the stagnation of QI, the stomach function regulating that helps digestion for Therapeutic Principle, can obtain desirable effect.We's determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, addition or subtraction of changes, Semen Armeniacae Amarum, Folium Perillae, Herba Asari lung qi dispersing cold expelling, expulsion cold in its side; Black Rhizoma Ligustici, Herba leucadis zeylanicae, Folium piperis betlis, duck sole of the foot flower, Herba Caryopteridis Terniflorae, Herba leerisae hexandrae, Folium Perillae Frutescentis expelling wind and cold; Radix Scutellariae, Herba Houttuyniae, Folium Mori, Rhizoma Osmundae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Taraxaci heat-clearing and toxic substances removing, removing heat-phlegm; Semen Ginkgo, Cortex Mori, Fructus Perillae, Flos Inulae, Radix Peucedani, Radix Asteris, Radix Stemonae lowering the adverse-rising QI to subdue asthma; Rhizoma Zingiberis Recens, Poria, Exocarpium Citri Rubrum damp eliminating reduce phlegm; Rhizoma Zingiberis Recens, Herba Asari, Herba Schizonepetae, Herba Menthae, Folium Mori, Bulbus Allii Fistulosi dispelling wind and removing obstruction in the collateral; Fructus Hordei Germinatus, raw Fructus Setariae Germinatus dispersing the stagnated live-QI to relieve the stagnation of QI, help digestion stomach function regulating; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, reduces phlegm.Make a general survey of full side, compatibility is rigorous.

Now the pharmacological properties effect of each taste medicine is described below:

Semen Ginkgo: property is put down, sweet in the mouth is pained; Enter lung, kidney channel.Astringe the lung gas, relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing, disinfection.Cure mainly asthma, phlegmatic cough, nocturnal emission, leucorrhea, nebulousurine, infantile diarrhea, malnutrition due to parasitic infestation, hemorrhoidal hamorrhage dysentery, gonorrhea, frequent micturition, and the disease such as scabies, dermatitis rhus, in vain tumor wind.The ginkgolic acid contained in Semen Ginkgo, bilobol, the experiment proved that antibacterial and bactericidal action, can be used for treating respiratory tract infectious disease.Semen Ginkgo water logging agent has inhibitory action in various degree to various fungus, can antipruritic treatment tinea.Ginkgolic acid contained in Semen Ginkgo episperm and bilobol etc., have the effect of anti-mycobacterium tuberculosis.Modern medicine study finds that numerous Semen Ginkgo has the effect of shrinking sphincter vesicae.For bed-wetting, deficiency of vital energy frequent micturition, leukorrhagia nebulousurine, the diseases such as seminal emission is not solid, have the effect of auxiliary treatment.Containing shikimic acid, ginkegetin, isoginkgetin, sterol etc. in Folium Ginkgo, being used for the treatment of the disease such as hypertension and coronary heart diseases and angina pectoris, cerebral vasospasm, hypercholesterolemia in recent years has certain effect.

Radix Scutellariae: property is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri is best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so house Radix Scutellariae can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, and first of this Gai Zhu section half exterior and half interior, agent is also." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Radix Scutellariae has antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus, there is certain inhibitory action, have good curative effect to upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc.

Folium Perillae: the property of medicine: pungent, warm.Return lung, spleen channel.Effect: induce sweat cold expelling, relieving QI stagnancy in the stomach, is applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Folium Perillae Herb all has very high nutritive value, and it has low sugar, high microsteping, high carotene, high mineral element etc.Containing perillaldehyde, perilla alcohol, menthone, menthol, eugenol, ergomaketon etc. in volatile oil.Defying age element SOD in every milligram of Folium Perillae content up to 106.2 micrograms.Find after deliberation, the each position of Folium Perillae evenly has good antitumaous effect, especially stronger with the effect in blade, oleanolic acid is wherein a kind of very strong natural anti-cancer agent, there is the effect of prophylaxis of tumours, there is again the effect of antiinflammatory, calmness, heart tonifying, diuresis, enhancing immunity, blood fat reducing and resistance growth of cancer cells.Folium Perillae can diaphoresis cold expelling to separate pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, therefore doublely to wind and cold table disease see symptoms of emesis uncomfortable in chest, use this product, be very suitable; Or the smooth symptom of the stagnation of QI is had without table disease, also can be used for a surname logical.As join Herba Pogostemonis, Pericarpium Citri Reticulatae then induce sweat and in, join the Rhizoma Pinelliae, Cortex Magnoliae Officinalis then resolving depression the chest stuffiness relieving.

Rhizoma Zingiberis Recens: pungent, sweet, warm.Attach to the lung and stomach meridians.Relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, warming stomach for dispelling cold, warming the lung to eliminate phlegm, preventing or arresting vomiting.Rhizoma Zingiberis Recens refers to the tuber stem of ginger, calls purple Rhizoma Zingiberis Recens, Rhizoma Zingiberis Recens, fresh ginger, old ginger.Warm in nature, its distinctive " gingerol " energy stimulating gastrointestinal mucosa, make gastrointestinal redness, digestion power strengthens, and effectively can treat the abdominal distention, stomachache, diarrhoea, vomiting etc. of eating cold and cool food and too much causing.After eating Rhizoma Zingiberis Recens, people has the sensation of body heat, this is because it can distend the blood vessels, blood circulation is accelerated, and impels pore with it to open, so not only the unnecessary torrid zone can be walked, also the pathogenic bacteria in body, cold are together taken out of simultaneously.When health has eaten cold and cool thing, be subject to drench with rain or stay in air-conditioned room long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because human body is trembled with fear the various discomforts remake.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian.Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.

Flos Inulae: salty, warm; Enter lung, liver, stomach warp.Function expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water." herbal classic ": " main stagnation of QI, fullness in the hypochondrium, palpitation with fear.Dewater, remove cold and heat between the five internal organs, invigorating middle warmer, the therapeutic method to keep the adverse QI flowing downwards." " property of medicine opinion ": " main rib side of body gas, lower cold and heat edema, cures mainly bladder retained water, goes by large abdomen, appetizing, the inverse not lower food of preventing or arresting vomiting." cure mainly expectorant knot in the heart, the lower distension of the side of body, cough with asthma, singultus, saliva as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.Chlorogenic acid has sensitization to people, sucks (as in coffee plant) after the dust of the plant containing chlorogenic acid, can pant, dermatitis etc., but can through the effect of intestinal secretion thing after eating, become without allergenic substance, therefore during test sensitinogen, Intradermal method should be used and without oral medication.

Radix Peucedani: cold nature, bitter in the mouth, pungent.Return lung; Spleen; Liver Channel.Belong to antitussive; Diaphoretic medicine.There is dispelling wind and heat pathogens; Effect of lowering the adverse-rising QI to resolve phlegm.Cure mainly loose wind heat clearing away, lowering the adverse-rising QI to resolve phlegm.Expire vexed for affection due to external wind and heat, lung-heat phlegm stagnancy, cough with asthma abundant expectoration, sticky, the inverse lack of appetite of expectorant Huang, chest and diaphragm." not Lu " be said: " painful abdominal mass in the full breast side of body of main treatment expectorant, stagnation of QI in chest and abdomen, wind headache, goes expectorant real, the therapeutic method to keep the adverse QI flowing downwards.Cure the wound cold and heat, pushes away Chen Zhixin, improving eyesight benefit essence "." detailed outline " cloud: " Radix Peucedani is brothers' medicines that too yin, yang is bright, rises with the pure sun of Radix Bupleuri, enters few sun, faints cloudy person's difference also.Its merit is longer than the therapeutic method to keep the adverse QI flowing downwards, therefore can control that expectorant dyspnea of heat type is coughed, all diseases of painful abdominal mass diaphragm vomiting.Under gas, then fire falls, and expectorant also falls, and oldly causing new achievement so have to push away, is mental disorder key medicine.TAO Hong-Jing says that itself and Radix Bupleuri are non-with merit, though control card with, institute enter lead then different ".

Herba Asari: acrid in the mouth, warm in nature.Lung meridian, kidney channel, heart channel, Liver Channel, gallbladder meridian, spleen channel.Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.Come from Shennong's Herbal, Herba Asari, the present has it everywhere, and so its place person of going out is true not as good as Hua Zhouzhe.Its root is thin and taste is extremely pungent, and therefore named says Herba Asari.Moderns are mainly with Herba Asari Forbesii when it, and Herba Asari Forbesii tells people, and the used time carefully must distinguish ear.At the beginning of the Herba Asari Forbesii spring on perennial root raw Seedling, leaf is like horseshoe-shape, and high two, three cun, stem, as wheat ligusticumic thickness, every nest has five, seven leaves or eight, nine leaves, not without branches and tendrils.With pasting raw pale reddish brown on reed head in crack between base of leaf again, its flower is seemingly shown in and loses, and pavilion is solid as large in bean, and have broken son in nest, seemingly Semen Hyoscyami, Seedling leaf is all blue or green, through frost and withered.Its root becomes nest, has like meal broom close noisy, elongated four, five cun, yellowish white.Acrid in the mouth.River, Huaihe River are exhaled as Herba Asari, with the many misuses of people, so describe mass dissipating and swelling eliminating in detail; Induce sweat cold expelling; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; The therapeutic method to keep the adverse QI flowing downwards is eliminated the phlegm, sensible.Mastalgia swells; Cold expelling dispels the wind; Pain relieving; Warming the lung to resolve fluid-retention; Sensible.Exterior syndrome due to wind-cold; Headache, toothache; Rheumatic arthralgia; Phlegm retention cough with asthma; Nasal obstruction; Nasal sinusitis; Aphtha.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.

Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.Concoct: be soaked in water, clean, slightly steam after profit, cut skin and block in time or cut sheet, drying.

Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet; Enter lung, Liver Channel.Dispelling wind to relieve the exterior syndrome, hemostasis, antipruritic, treat skin ulcer.Main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints." Japan hanako materia medica ": " sharp the five internal organs, removing stagnancy of indigested food and making QI downward, relieving alcoholic intoxication.Heat-dissipating of cooking is eaten and is simmered tea, and controls wind syndrome of head and antiperspirant goes out; Semen Glycines preparatum decoct control violent trauma tremble with fear." " detailed outline ": " throat, the skin ulcer that disappears swells for loose wind heat, refresh oneself.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.Make fever in rabbits with typhoid fever polyvalent vaccine, give Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, find that there is faint refrigeration function.Herba Schizonepetae oil can reduce normal rat body temperature; Also have sedation, Herba Schizonepetae oil (0.5ml/kg) is to rabbit gavage, and its movable minimizing as seen, limb muscle is slightly lax.Herba Schizonepetae oil can obviously extend acetylcholine and histamine mixed liquor causes the incubation period of breathing heavily to Cavia porcellus, reduces the number of animals occurring to twitch; The guinea pig tracheal smooth muscle that also can cause anti-acetylcholine or histamine is shunk; Still there is phlegm-dispelling functions.

Radix Asteris: warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Cure mainly cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.Be used for the treatment of chronic cough asthma.From Radix Asteris, isolated epifriedelanol has certain antitumaous effect to ehrlich carcinoma, anesthetized rabbit gavages decoct 1 g/kg, have remarkable phlegm-dispelling functions (respiratory tract secretory volume algoscopy), act on sustainable more than 4 hours, crude extract is oral also to be had significantly increasing action rat trachea secretions.In vitro tests has certain inhibitory action to escherichia coli, dysentery bacterium (Song Nei Shi), Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus and vibrio cholera etc.

Herba Menthae: nature and flavor are pungent is cool.Enter lung meridian, Liver Channel.For anemopyretic cold, epidemic febrile disease from the beginning of.These product are pungent to disperse, cool to heat clearing away, clear light cool loose, are the product that dispelling wind and heat pathogens is conventional, thus available control anemopyretic cold or epidemic febrile disease from the beginning of, evilly to defend point, headache, heating, the micro evil wind person of trembling with fear, often join Flos Lonicerae, Fructus Forsythiae, Fructus Arctii, the equivalent use of Herba Schizonepetae.For conjunctival congestion of having a headache, laryngopharynx swelling and pain.These product lightly float and rise floating, awakening consciousness, and merit is kind evacuates part of the body cavity above the diaphragm housing the heart and lungs wind heat, refresh oneself, throat.Attack with controlling in wind heat, headache conjunctival congestion, polygamy closes Folium Mori, Flos Chrysanthemi, Fructus Viticis is equivalent uses; Stopping up Sheng, laryngopharynx swelling and pain with controlling wind heat, often joining Radix Platycodonis, Radix Glycyrrhizae, Bombyx Batryticatus, Herba Schizonepetae, the equivalent use of Radix Saposhnikoviae.Modern study shows, Herba Menthae has antivirus action; Analgesia, itching-relieving action; Irritation, antitussive action; Bactericidal action; Antibacterial action: Herba Menthae has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, oral disease, makes breath freshening.Gargle with mint tea juice, can be anti-halitosis in advance.It is said and can be used for the another name that Herba Menthae also has " eyes grass " treating ophthalmic.Physiological function: Herba Menthae is the best quintessence oil for the treatment of flu, can suppress fever and mucosa irritation, and promote perspire; Cleaning throat and moistening larynx, elimination halitosis have good effect; Effect of relieveing pain and refreshing, can alleviate headache, migraine and toothache; In addition for respiratory system, digestive system, hormonal system, good effect is had.

Semen Raphani: property is put down, acrid in the mouth, sweet; Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.Enter spleen, stomach, lung meridian, can help digestion de-swelling, and effect is remarkable, has the title of " rush wall fall wall ".Clinical habit is used for the treatment of real (eat, wet, stagnate) card.But these product are not only the de-swellings that helps digestion, and to deficiency syndrome with it, obtain effect also good, because of its property peace, its abnormal smells from the patient is not high again, and what without the fraud of victory partially, can not be limited to " rush wall fall wall " says there is the suspicion of dispelling the stagnated QI (being having a surplus of flat gas actually), and gives it up.Semen Raphani water extract has significant inhibitory action to staphylococcus and escherichia coli etc., and water extract has obvious hypotensive effect, for anesthetized rabbit, cat and dog, animal blood pressure all can be caused during intravenous injection to decline.

Herba Houttuyniae: cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The function of inducing diuresis for treating stranguria syndrome.Cure mainly the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.Modern multiplexly control lung abscess, pneumonia, acute and chronic tracheitis, urinary tract infection etc.Modern pharmacology experiment shows, these product have the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, upper respiratory tract infection, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, pulmonary carcinoma, cervical erosion, suppurative arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitisshock, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurative otitis media, mumps, pimple shape urticaria, chronic pharyngitis, anorectal disease, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.

Folium Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.Dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dense the boiling of dry person.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and Zheng Hou An; Scolopendra stings snakeworm, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.Containing trypsininhibitory substance in Fructus Mori, cause the digestive enzyme in intestinal can not destroy C type and produce bacillus capsulatus B toxin, and causing bleeding property enteritis.Fructus Mori fatty acids, excessive eating can produce irritation to digestive tract.

Rhizoma Osmundae: nature and flavor are bitter, are slightly cold.Return liver, spleen channel.There is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of parasite killing.Anemopyretic cold can be cured mainly, maculae caused by violent heat pathogen; Heat in blood is hemorrhage; Worm disease; This product also can be used for treatment burn and scald and injures married woman and be with inferior disease.Shennong's Herbal cloud: " main abdomen be possessed steam, all poison, kill three worms ".Main containing bright and beautiful Ma Su, Tectaria subtriphlla's powder, flavaspidic acid, bright and beautiful horse subacid, volatile oil, bright and beautiful horse tannin etc.Bright and beautiful horse acid contained by this product, yellow bright and beautiful horse acid have stronger anthelmintic action, have strong toxicity, ancylostome can be made to benumb and discharge, also have and drive away the parasitic effect such as ancylostome, ascarid cestode.Experiment proves that this product can strong inhibition influenza virus, also has stronger antivirus action to adenovirus, poliovirus, encephalitis b virus etc.External has hemostasis, analgesia, antiinflammation.Its decoct and extract have significant excitation to Rabbit Uterus.Brocade horse have poison, can voluntary muscle be benumbed, have stimulation to gastrointestinal tract, cause retinal angiospasm and injury optic nerve, cause central nervous system disorder time poisoning, see tremble, faints from fear so medulla oblongata benumb.Brocade Ma Su does not generally absorb at intestinal, but when having fattiness in intestinal, and can penetration enhancement and arrive poisoning.According to clinical report, Rhizoma Osmundae has better effect to multiple disease of viral infection, is widely used in the Prevention and Curation of flu, influenza and upper respiratory tract infection.

Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae): slightly sweet flavor, property is put down.Function cures mainly: relieving the exterior syndrome heat clearing away, removing toxic substances, dissipating blood stasis.Control influenza, encephalitis b, laryngopharynx swelling and pain, enteritis, dysentery, jaundice, acute appendicitis, infantile convulsion, infantile malnutrition, skin ulcer muscle scabies hemorrhoid.1. " the SHENGCAO property of medicine standby want ": " wash mange, separate skin infection, antipruriticly bury mouth." 2. " south of the Five Ridges gather medicinal herbs record ": " heat-clearing and toxic substances removing, moves back fever caused by exogenous pathogens.Decoct washing chancre." 3. " Nanning City's medicine will ": " heat-clearing and toxic substances removing, controls enteritis dysentery, jaundice, burning hot acute filthy disease; External application is controlled shrimp pincers skin ulcer and is washed skin infection." 4. " Guangdong Chinese medicine " II: " controls affection by summer-heat heating, abnormal pigmentary deposit on the skin acute diseases such as cholera and sunstroke, hemorrhoid (outer Xian), and acute appendicitis and Medicine and Surgery inflammation swell." 5. Guangzhou army " conventional Chinese herbal medicine handbook ": " heat-clearing and toxic substances removing, removing blood stasis and activating blood flow.Control influenza, treatment laryngopharynx swelling and pain, fever of children, infantile convulsion, traumatic injury, chronic ulcer, prurigo."

Exocarpium Citri Rubrum: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.Certainly, all explanations are all relevant with spleen with wet, so its property of medicine effect performance leeway is larger, all can use in general activating QI to eliminate phlegm side.Have hypotensive effect slowly to anesthetized rabbit, cat, dog intravenous injection, its decompression principle is owing to directly acting on vascular smooth muscle.

Fructus Hordei Germinatus: nature and flavor are sweet is flat.Return spleen, stomach warp, Liver Channel.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension." Japan hanako materia medica ": " appetizing, only cholera, relieving restlessness, expectorant, broken crux, can expedite the emergence of tire for warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " anti-nausea, disappear dyspepsia, only acid regurgitation acid regurgitation, antidiarrheal, the wide diaphragm of the stomach that disappears, and control married woman's milk breast and do not receive, and milk is more than for alleviating distention in middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." there is promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back effect of newborn relieving distension.Cure mainly food stagnation not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, and women weans.

Raw Fructus Setariae Germinatus: sweet is flat.Return spleen, stomach warp.The appetizing of fast spleen, the therapeutic method to keep the adverse QI flowing downwards and in, promoting digestion and removing stagnation." herbal classic is met former ": " Fructus Setariae Germinatus, opens spleen feed, alleviating distention in middle-JIAO rapid digestion of food, and can invigorating middle warmer, gram to cut also not like Fructus Hordei Germinatus." " Chinese crude drug handbook ": " control insufficiency of the spleen, the heart is had a stomachache, and distension, pyretic toxicity dysentery, excessive thirst, becomes thin." Compendium of Material Medica: " and the appetizing of fast spleen, the therapeutic method to keep the adverse QI flowing downwards and in, promoting digestion and removing stagnation." help digestion and in, spleen benefiting and stimulating the appetite.Do not disappear for food stagnation, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.Fructus Setariae Germinatus (parched) relatively helps digestion, for not hungry lack of appetite.It is stagnant that Fructus Setariae Germinatus (parched to brown) is apt to eliminate indigestion, do not disappear for stagnant.These product help digestion and in, effect is gentle, the aid digestion and gas that do not injure one's stomach.Normal and Fructus Hordei Germinatus mutual reinforcement between is use, to improve curative effect.Fructus Setariae Germinatus has antiallergic activity by suppressing mast cell histamine release.

Bulbus Allii Fistulosi: pungent, temperature.Enter lung, stomach warp.Relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, pungent fragrant dredging collateral, lung qi dispersing dispels the wind." Japan hanako materia medica ": " when controlling day row, disease, has a headache fanatical, logical intestine and small intestine, cramp caused by acute vomiting and diarrhea and beautifully adorned globefish gas, beriberi, cardiac and abdominal pain, dizzy and only mental confusion due to heart disorder is vexed." Compendium of Material Medica: " except rheumatism, general pain paralysis, malnutrition due to parasitic infestation is pained, only adult Yang Tuo, insidious stomachache, and children's is coiled enteral and fished, married woman's gestation hematuria, logical milk, loose acute mastitis, and sharp tinnitus, is coated with dog poison." function is delivered, activates yang, detoxified, parasite killing.Cure mainly cold, YIN-cold is suffered from abdominal pain, constipation and anuresis, dysentery, sore, carbuncle and painful swelling, abdominal pain due to worm stagnation.Bulbus Allii Fistulosi in vitro shigella has inhibitory action.Water logging agent tube dilution method, 1:10 has inhibitory action to trichophyton, microsporon audouini etc.The filtrate 1:4 of grinding had killing action through 30 minutes to trichomonas vaginitis in vitro.

The Radix Stemonae: nature and flavor are sweet, bitter, tepor.Return lung meridian.There is nourishing the lung to arrest cough, effect of parasite killing delousing.Main new chronic cough is coughed, pulmonary tuberculosis, pertussis, enterobiasis, body louse, tinea scabies.Can nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing." the southern regions of the Yunnan Province book on Chinese herbal medicine " records it: " lung moistening, controls cough due to lung-heat; Sputum eliminating to stop asthma, only chronic consumptive disease cough, parasite killing ".There is nourishing the lung to arrest cough, effect of parasite killing delousing.Main new chronic cough is coughed, pulmonary tuberculosis, pertussis, enterobiasis, body louse, tinea scabies.Can nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendum Pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.Pharmacological research shows, the Radix Stemonae has antitussive, phlegm-dispelling functions; Resisting pathogenic microbes effect; Insecticidal action etc.Modern times are used for the cough preventing and treating chronic bronchitis, the dry cough of pulmonary tuberculosis, the cards such as pertussis.

Herba Taraxaci: nature and flavor are sweet, micro-hardship, cold.Enter spleen, stomach, kidney three warp.Heat-clearing and toxic substances removing, draws out pus by applying a plaster to the affected part and attacks carbuncle, inducing diuresis for treating stranguria syndrome." Bencao Jingshu ": " Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast poison, and should give birth to warm good." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " apply all pyogenic infections from tumour or sore, the ruined tinea skin ulcer of scabies; Dispel the wind, disappear all sores, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Can be used for upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Experiment proves, Herba Taraxaci is to staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi, micrococcus catarrhalis etc., all there is killing action, also have certain inhibitory action to tubercule bacillus, some fungus and virus.Therefore antibiotic usage can be replaced to a certain extent.

Black Rhizoma Ligustici: Umbelliferae Ligustrum plant fern leaf Rhizoma Ligustici Ligusticum pteridophyllum Franch., is used as medicine with root.Autumn and winter gather, and clean and dry.Nature and flavor are pungent, temperature.Function cures mainly dispersing cold for relieving pain.For anemofrigid cold, headache, migraine, nervous headache, cold syndrome of the stomach pain, muscle arthralgia.

Herba leucadis zeylanicae: nature and flavor Guangzhou army " conventional Chinese herbal medicine handbook ": " toil, temperature." function cures mainly and induces sweat, and cough-relieving is stimulated the menstrual flow, improving eyesight.Cure cold, cough, asthma, pertussis, amenorrhea, nyctalopia, scabies.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " wind dispelling induces sweat, relieving cough and resolving phlegm.Cure cold, cough, acute toothache, gastrointestinal upset, pertussis." 2. " mountain of papers Chinese herbal medicine ": " cough-relieving of inducing sweat, improving eyesight is stimulated the menstrual flow.Cure cold, headache, body cave, bronchial asthma, amenorrhea, dyspepsia, nyctalopia." 2. " register planted by Guangxi medicine ": " controls scabies, dermatosis."

Folium piperis betlis: nature and flavor are pungent, temperature.1. Tang Materia Medica: " acrid in the mouth." 2. " herbal classic is met former ": " is pungent, temperature, nontoxic." function cures mainly dampness, killing parasites for relieving itching.Control cough due to wind and cold, stomachache, pathogenic wind-toxic beriberi, edema during pregnancy, mange, eczema, tinea pedis, scald.1. " detailed outline ", " separate communicable subtropical diseases, remove evil gas in the heart, warming the spleen dampness." 2. " herbal classic is met former ": " therapeutic method to keep the adverse QI flowing downwards warming middle-JIAO, broken expectorant, eliminating stagnation gas." 3. " book on Chinese herbal medicine asks former ": " washes pathogenic wind toxic swelling of the feet, mange." 4. " age south gather medicinal herbs record ": " controls cough due to wind and cold, retention of placenta, horse mouth furuncle and burn." 5. " Luchuan book on Chinese herbal medicine ": " anthelmintic, detumescence, antipruritic, removing the necrotic tissue and promoting granulation.Control infantile malnutrition furuncle, ulcer, carious pain." 6. " south of the Five Ridges herbal ": " applies sore, smoked hemorrhoid, reason traumatic injury." 7. " Guangdong Chinese herbal medicine ": " controls edema during pregnancy, furuncle, skin eczema, tinea pedis, cold syndrome of the stomach pain."

Duck sole of the foot flower: habitats distribution Shaanxi, Gansu, Qinghai, Xinjiang, Sichuan, Yunnan, Tibet.Nature and flavor are pungent, temperature.Function cures mainly expelling wind and cold, dredging collateral of having one's ideas straightened out.

Herba Caryopteridis Terniflorae: Verenaceae Caryopteris plants three flower Herba caryopteridis nepetaefoliae Caryopteris terniflora Maxim., with all herbal medicine.Summer, full-bloom stage was gathered, using fresh herb or dry in the shade.Nature and flavor are pungent, temperature.Function cures mainly delivers cold expelling, lung qi dispersing cough-relieving, promoting blood flow to regulate menstruation.For cold cough, chronic bronchitis, pertussis, stimulates the menstrual flow, puerperal abdonimal pain; Knife injury is controlled in external, burn and scald, venom.

Herba leerisae hexandrae: nature and flavor " Traditional Chinese Medicine in Sichuan will ": " property is put down, and puckery is nontoxic." function cures mainly the cold expelling that induces sweat, the meridian dredging, diuresis.Cure cold, headache body pain, malaria, arthralgia pain is numb, leucorrhea.1. " classify herbal ": " control leucorrhea, stimulate the menstrual flow." 2. " conventional glossary of Herbs and Drugs among the people ": " expelling cold and relieving exterior syndrome, diuretic dehumidifies.Control numb limbs and tense tendons." 3. " Traditional Chinese Medicine in Sichuan will ": " energy expelling cold and relieving exterior syndrome, the meridian dredging.Treating malaria disease, flu head-body-pain."

Folium Perillae Frutescentis: nature and flavor are pungent, temperature.1. the Meng numerous: " warm in nature." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " acrid in the mouth, warm in nature, nontoxic." returning through " book on Chinese herbal medicine converges and says ": " starts with, meridian of Foot-TAI YIN." function cures mainly and induces sweat, and cold expelling is regulated the flow of vital energy, and helps digestion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, and food stagnation is vomited and diarrhoea, cold-dysentery.1. " not Lu ": " in homophony, gas of deodorizing." 2. supplement to the Herbal: " smashes deposited insect bite." 3. " Japan hanako materia medica ": " regulating QI, profit cardiopulmonary, longue skin, beneficial color, disappear dyspepsia, only upper gas cough, and go bromhidrosis, deposited Serpentis stings." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cure the wound cold heating, lossless, headache, and all wind and cold expectorant gush and tie, cramp caused by acute vomiting and diarrhea, and cough is spat, little eclampsia disease.Analgesic therapy, Zhichuan." 5. " the SHENGCAO property of medicine is standby to be wanted ": " therapeutic method to keep the adverse QI flowing downwards, except rheumatism." 6. " Fujian traditional herbal medicine ": " disappear cold air, and only cold-dysentery, dispels the wind antipyretic, and anthelmintic is detoxified."

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 granule

Semen Ginkgo 7 parts, Radix Scutellariae 20 parts, Folium Perillae 10 parts, 25 parts, Rhizoma Zingiberis Recens, 30 parts, Radix Glycyrrhizae, Flos Inulae 5 parts, Radix Peucedani 25 parts, Herba Asari 6 parts, 20 parts, Poria, Herba Schizonepetae 20 parts, Radix Asteris 30 parts, Herba Menthae 20 parts, Semen Raphani 20 parts, Herba Houttuyniae 30 parts, 20 parts, Folium Mori, Rhizoma Osmundae 4 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 parts, Exocarpium Citri Rubrum 10 parts, Fructus Hordei Germinatus 9 parts, raw Fructus Setariae Germinatus 14 parts, Bulbus Allii Fistulosi 20 parts, the Radix Stemonae 30 parts, Herba Taraxaci 30 parts, black Rhizoma Ligustici 14 parts, Herba leucadis zeylanicae 20 Fen, Folium piperis betlis 25 parts and the duck sole of the foot spend 24 parts;

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 80%, be heated to boiling reflux 3 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.06Mpa, relative density is the mastic of 1.04, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 2 tablet

Semen Ginkgo 7 parts, Radix Scutellariae 20 parts, Folium Perillae 10 parts, 25 parts, Rhizoma Zingiberis Recens, 30 parts, Radix Glycyrrhizae, Flos Inulae 5 parts, Radix Peucedani 25 parts, Herba Asari 6 parts, 20 parts, Poria, Herba Schizonepetae 20 parts, Radix Asteris 30 parts, Herba Menthae 20 parts, Semen Raphani 20 parts, Herba Houttuyniae 30 parts, 20 parts, Folium Mori, Rhizoma Osmundae 4 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 parts, Exocarpium Citri Rubrum 10 parts, Fructus Hordei Germinatus 9 parts, raw Fructus Setariae Germinatus 14 parts, Bulbus Allii Fistulosi 20 parts, the Radix Stemonae 30 parts, Herba Taraxaci 30 parts, black Rhizoma Ligustici 14 parts, Herba leucadis zeylanicae 20 parts, Folium piperis betlis 25 parts, the duck sole of the foot spends 24 parts, Herba Caryopteridis Terniflorae 14 parts, Herba leerisae hexandrae 25 parts and Folium Perillae Frutescentis 10 parts,

Preparation method comprises:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 80%, reflux 1 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.05 times of lactose, the starch of 0.1 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.001 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 3 honey refining pill

Its preparation method comprises the following steps:

Step 2: get 85% soak with ethanol 0.5 hour, heating extraction 2 times that surplus stock medical material adds 2 times amount again, each 0.5 hour, filter to obtain extracting solution, merge extractive liquid, be the ultrafiltration post ultrafiltration of 84000 again through the molecular weight that dams, ultrafiltration decompression removing ethanol, during simmer down to 80 DEG C, relative density is the extractum of 1.1, becomes component 1;

Step 3: the medicinal residues that step 2 obtains add 1 times amount water soaking 1.0 hours, extracts 1 time, is the extractum of 1.1, as component 2 by relative density during extracting solution heating under reduced pressure simmer down to 90 DEG C for 1.0 hours;

Step 4: component 1, component 2 are mixed with the powder that step 1 obtains, adds and is twisted into honey refining pill relative to the Mel of mixture 2 times amount.

The toxicity test of medicine

1. acute toxicity test: with the granule of the embodiment of the present invention 1 for object, gives white mouse large enteral dispensing, observes 14 for 200 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse vagina and damaged skin, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable.

2. long term toxicity test: the tablet of the embodiment of the present invention 2 is pressed 6,18 and 30g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

3. cumulative toxicity test: select 20 healthy mices, female, each 10 of hero, with the honey of the embodiment of the present invention 3 refining pill for object, dose design is first phase in every 7 days, each issue dosage is respectively 0.10LD50,0.2LD50,0.3LD50,0.4LD 50,0.5LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,1000,1500,2000,2500m part/k part BW).Within every 7 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Illustrate that medicine of the present invention does not have cumulative toxicity.

Clinical data

200 routine patients are the patient that first class hospital of Shandong Province three is diagnosed as phlegm-heat accumulated in the lung type mycoplasma pneumonia.Patient is divided into treatment one group first at random, treats two groups, treats three groups and matched group, often organize 50 people.Four groups of patients comparing difference not statistically significant in age, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.

Diagnostic criteria

1. 6 ~ 35 days incubation periods, average 3 weeks.

2. sings and symptoms: state of an illness weight differs, can interstitial pneumonia from asymptomatic to serious.Model case shows: onset is slow, sick just only have headache (69.8%) and weak, after 2 ~ 3 days, symptom increases the weight of gradually, there is heating, shiver with cold (56%), pharyngalgia (52.7%), myalgia (41.8%) and cough (patient of 10% is without cough) occur immediately.Be initially dry cough, cough afterwards for obstinate spastic play, light night day is heavy, even affects sleep, and play is coughed and can be caused facial edema, uncomfortable in chest, chest pain, dizziness, headache, dry cough without phlegm or cough rear adularescent mucus expectorant and purulent sputum, is sometimes with the blood streak or spitting of blood.There is retrosternal pain in small number of patients.Heating sees the patient of more than 80%, and pattern of fever is indefinite, and body temperature is everlasting about 39 DEG C, hot journey about 1 ~ 2 week.

3. phlegm-heat accumulated in the lung type: nasal obstruction watery nasal discharge, headache pharyngalgia, cough is coughed up phlegm, and flat sleeping or nocturnal cough increases the weight of, floating and tense pulse.

Therapeutic Method

Treat one group: this is organized 50 people and uses the granule of embodiments of the invention 1 to treat.Every day 2 times, each 5g boiled water is taken after mixing it with water, and within 14 days, is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.

Treat two groups: this is organized 50 people and uses the tablet of embodiments of the invention 2 to treat.Every day 2 times, each 2 14 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.

Treat three groups: this is organized 50 people and uses the honey of embodiments of the invention 3 refining pill to treat.Every day 2 times, each 1 ball 14 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.

Matched group: this is organized 50 people and uses erythromycin to treat.Erythromycin 30 ~ 50mg/ (kg d), points 4 times oral, adult 1.5g/d, and points 3 times oral, and within 14 days, be a course for the treatment of, 2 courses for the treatment of are carried out in treatment.

Criterion of therapeutical effect

Recovery from illness: symptom, sign disappear; Take a turn for the better: heat is moved back, and cough alleviates, pulmonary rale reduces, and chest x sheet shows that pathological changes obviously absorbs.Invalid: symptom, sign are without obvious change.

Therapeutic outcome

Table 1 is the therapeutic effect contrast of each group

Group	Recovery from illness	Take a turn for the better	Invalid
				Treat one group	48（96%）	1（2%）	1（2%）
Treat two groups	49（98%）	1（2%）	0（0%）
				Treat three groups	49（98%）	1（2%）	0（0%）
Matched group	35（70%）	5（10%）	10（20%）

As can be seen from Table 1, the therapeutic effect of three treatment groups is obviously all better than matched group, it can thus be appreciated that medicine of the present invention, and treatment phlegm-heat accumulated in the lung type mycoplasma pneumonia, good effect, determined curative effect.

Table 2 is the side effect contrast of each group

Group	There is number in side effect	Side effect occurrence rate
			Treat one group	0	0
Treat two groups	0	0
			Treat three groups	0	0
Matched group	15	30%

As can be seen from Table 2, not there is side effect in the patient of three treatment groups, and matched group patient occurs side effect over the course for the treatment of over the course for the treatment of. it can thus be appreciated that, medicine of the present invention, in treatment phlegm-heat accumulated in the lung type mycoplasma pneumonia, treatment can not have side effects, safe and effective.

Table 3 is the time contrast of the recovery from illness number treatment of each group

Group	Recovery from illness number	1st course for the treatment of	2nd course for the treatment of
				Treat one group	48	25（52.08%）	23（47.92%）
Treat two groups	49	27（55.1%）	22（44.9%）
				Treat three groups	49	26（53.06%）	23（46.94%）
Matched group	35	15（42.86%）	20（57.14%）

As can be seen from Table 3, the treatment time of three treatment groups, just good than matched group at the therapeutic effect of short time.It can thus be appreciated that medicine of the present invention, in treatment phlegm-heat accumulated in the lung type mycoplasma pneumonia, therapeutic effect is good, and curative effect is fast.

In sum, medicine of the present invention, in treatment phlegm-heat accumulated in the lung type mycoplasma pneumonia, therapeutic effect is good, and curative effect is fast, and determined curative effect is safe and effective, without recurrence, and has no side effect.

Typical case: in December, 2013, Linyi City institute of traditional Chinese medicine, Guo, man, 37 years old, because there being nasal obstruction watery nasal discharge, headache pharyngalgia, cough is coughed up phlegm, and flat sleeping and nocturnal cough increases the weight of, floating and tense pulse, medical, nasopharynx part and conjunctival congestion on inspection, edema, have cervical lymph node enlargement, erythra, auscultation of lung can have fine rales, x line rabat is enhanced lung markings, and pulmonary parenchyma can have polymorphic infiltration shape, common with inferior lobe, Serological testing: detect mycoplasma pneumoniae antigen, is diagnosed as phlegm-heat accumulated in the lung type mycoplasma pneumonia.The honey of embodiments of the invention 3 refining pill is used to treat.Every day 2 times, each 1 ball 14 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.Recovery from illness.Later stage follow-up is not recurred half a year.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of phlegm-heat accumulated in the lung type mycoplasma pneumonia for one kind, it is characterized in that, described medicine comprises following raw medicinal material: Semen Ginkgo, Radix Scutellariae, Folium Perillae, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Flos Inulae, Radix Peucedani, Herba Asari, Poria, Herba Schizonepetae, Radix Asteris, Herba Menthae, Semen Raphani, Herba Houttuyniae, Folium Mori, Rhizoma Osmundae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Exocarpium Citri Rubrum, Fructus Hordei Germinatus, raw Fructus Setariae Germinatus, Bulbus Allii Fistulosi, the Radix Stemonae, Herba Taraxaci, black Rhizoma Ligustici, Herba leucadis zeylanicae, Folium piperis betlis and duck sole of the foot flower.

2. medicine according to claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 4-7 weight portion, Radix Scutellariae 15-20 weight portion, Folium Perillae 10-15 weight portion, Rhizoma Zingiberis Recens 20-25 weight portion, Radix Glycyrrhizae 25-30 weight portion, Flos Inulae 2-5 weight portion, Radix Peucedani 20-25 weight portion, Herba Asari 3-6 weight portion, Poria 10-20 weight portion, Herba Schizonepetae 15-20 weight portion, Radix Asteris 20-30 weight portion, Herba Menthae 10-20 weight portion, Semen Raphani 10-20 weight portion, Herba Houttuyniae 20-30 weight portion, Folium Mori 15-20 weight portion, Rhizoma Osmundae 4-6 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 weight portion, Exocarpium Citri Rubrum 10-14 weight portion, Fructus Hordei Germinatus 9-13 weight portion, raw Fructus Setariae Germinatus 8-14 weight portion, Bulbus Allii Fistulosi 20-25 weight portion, Radix Stemonae 25-30 weight portion, Herba Taraxaci 20-30 weight portion, black Rhizoma Ligustici 10-14 weight portion, Herba leucadis zeylanicae 15-20 weight portion, Folium piperis betlis 20-25 weight portion and duck sole of the foot flower 14-24 weight portion.

3. medicine according to claim 1, is characterized in that, also comprises Herba Caryopteridis Terniflorae, Herba leerisae hexandrae, Folium Perillae Frutescentis, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 4-7 weight portion, Radix Scutellariae 15-20 weight portion, Folium Perillae 10-15 weight portion, Rhizoma Zingiberis Recens 20-25 weight portion, Radix Glycyrrhizae 25-30 weight portion, Flos Inulae 2-5 weight portion, Radix Peucedani 20-25 weight portion, Herba Asari 3-6 weight portion, Poria 10-20 weight portion, Herba Schizonepetae 15-20 weight portion, Radix Asteris 20-30 weight portion, Herba Menthae 10-20 weight portion, Semen Raphani 10-20 weight portion, Herba Houttuyniae 20-30 weight portion, Folium Mori 15-20 weight portion, Rhizoma Osmundae 4-6 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 weight portion, Exocarpium Citri Rubrum 10-14 weight portion, Fructus Hordei Germinatus 9-13 weight portion, raw Fructus Setariae Germinatus 8-14 weight portion, Bulbus Allii Fistulosi 20-25 weight portion, Radix Stemonae 25-30 weight portion, Herba Taraxaci 20-30 weight portion, black Rhizoma Ligustici 10-14 weight portion, Herba leucadis zeylanicae 15-20 weight portion, Folium piperis betlis 20-25 weight portion, duck sole of the foot flower 14-24 weight portion, Herba Caryopteridis Terniflorae 10-14 weight portion, Herba leerisae hexandrae 20-25 weight portion and Folium Perillae Frutescentis 10-20 weight portion.

4. medicine according to claim 1 and 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 7 weight portion, Radix Scutellariae 20 weight portion, Folium Perillae 10 weight portion, Rhizoma Zingiberis Recens 25 weight portion, Radix Glycyrrhizae 30 weight portion, Flos Inulae 5 weight portion, Radix Peucedani 25 weight portion, Herba Asari 6 weight portion, Poria 20 weight portion, Herba Schizonepetae 20 weight portion, Radix Asteris 30 weight portion, Herba Menthae 20 weight portion, Semen Raphani 20 weight portion, Herba Houttuyniae 30 weight portion, Folium Mori 20 weight portion, Rhizoma Osmundae 4 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 weight portion, Exocarpium Citri Rubrum 10 weight portion, Fructus Hordei Germinatus 9 weight portion, raw Fructus Setariae Germinatus 14 weight portion, Bulbus Allii Fistulosi 20 weight portion, the Radix Stemonae 30 weight portion, Herba Taraxaci 30 weight portion, black Rhizoma Ligustici 14 weight portion, Herba leucadis zeylanicae 20 weight portion, Folium piperis betlis 25 weight portion and the duck sole of the foot spend 24 weight portions.

5. the medicine according to claim 1 or 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Semen Ginkgo 7 weight portion, Radix Scutellariae 20 weight portion, Folium Perillae 10 weight portion, Rhizoma Zingiberis Recens 25 weight portion, Radix Glycyrrhizae 30 weight portion, Flos Inulae 5 weight portion, Radix Peucedani 25 weight portion, Herba Asari 6 weight portion, Poria 20 weight portion, Herba Schizonepetae 20 weight portion, Radix Asteris 30 weight portion, Herba Menthae 20 weight portion, Semen Raphani 20 weight portion, Herba Houttuyniae 30 weight portion, Folium Mori 20 weight portion, Rhizoma Osmundae 4 weight portion, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 weight portion, Exocarpium Citri Rubrum 10 weight portion, Fructus Hordei Germinatus 9 weight portion, raw Fructus Setariae Germinatus 14 weight portion, Bulbus Allii Fistulosi 20 weight portion, the Radix Stemonae 30 weight portion, Herba Taraxaci 30 weight portion, black Rhizoma Ligustici 14 weight portion, Herba leucadis zeylanicae 20 weight portion, Folium piperis betlis 25 weight portion, the duck sole of the foot spends 24 weight portions, Herba Caryopteridis Terniflorae 14 weight portion, Herba leerisae hexandrae 25 weight portion and Folium Perillae Frutescentis 10 weight portion.

6. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is granule, and its preparation method comprises the following steps:

7. the medicine according to any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:

8. a preparation method for the medicine described in any one of claim 1 to 5, is characterized in that, the dosage form of described medicine is honey refining pill, and its preparation method comprises the following steps: