CN105748854A - Buccal pill for treating acute radiation esophagitis and preparation method - Google Patents

Buccal pill for treating acute radiation esophagitis and preparation method Download PDF

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CN105748854A
CN105748854A CN201610283174.2A CN201610283174A CN105748854A CN 105748854 A CN105748854 A CN 105748854A CN 201610283174 A CN201610283174 A CN 201610283174A CN 105748854 A CN105748854 A CN 105748854A
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herba
pill
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tremella
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孙自营
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Abstract

The invention discloses a buccal pill for treating acute radiation esophagitis.The buccal pill is prepared from, by weight, 20-30 parts of white fungus, 5-15 parts of spreading hedyotis herb, 5-15 parts of rhodiola rosea, 6-16 parts of oysters, 10-20 parts of boschniakia rossica, 15-25 parts of acorus calamus, 1-5 parts of citrus aurantium, 8-20 parts of chicken's gizzard-membrane, 10-15 parts of celery, 2-6 parts of cassia occidentalis, 10-30 parts of garlic powder, 20-40 parts of grape seeds and 6-13 parts of citri reticulatae viride.The buccal pill has the advantages of being free of stimulation, good in effect and easy to accept, and Chinese herbs which are common locally are adopted as raw materials to prepare the buccal pill through a special processing technology.

Description

That treats acute radiation-induced esophagitis sucks pill and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, especially relate to a kind of treat acute radiation-induced esophagitis suck pill and Its preparation method.
Background technology
Radiotherapy is called for short radiotherapy, is widely used in the process of mediastinum thoracis malignant tumor, but owing to lonizing radiation are to life The ionization that object produces, also can make normal structure and cell be damaged and destroy.The squamous epithelial cancer of esophagus is to radioactivity Material is more sensitive, therefore, is likely to occur Radiotion esophageal disease, especially enters with chemotherapy when radiotherapy simultaneously in Patients During Radiotherapy During row, this esophageal injury can be more serious.This because of the esophageal injury caused by lonizing radiation, referred to as radiation esophagitis.
The cause of disease: radiotherapy (radiation) can make living organism produce ionization, and causes a series of pathologic-physiological reaction, Destroy and damage histiocyte.Radiation esophagitis often betide in the Patients During Radiotherapy of the thoracic malignant tumors such as pulmonary carcinoma and mediastinum or Afterwards, the radiotherapy of Oropharynx malignant tumor is the most indirectly betided.Radiotherapy dosimetry 30Gy can cause the damage of nervus esophagi muscle, Cause the wriggle weakness of esophagus, even disappear.Along with dose radiation increases, esophageal injury is the heaviest.The ionization of lonizing radiation itself Effect can make esophageal epithelial cell damage, necrosis.On this basis, due to slowing down of esophageal peristalsis, harmful substance is caused to pass through Esophagus time lengthening, has increased the weight of this damage.Additionally, radiotherapy can cause body leukopenia, immunity of organisms lowers, thus Cause esophagus to infect, esophagitis occurs.
Clinical manifestation: 50%～70% patient accepting radiation occurs Nausea and vomiting, chest pain, heating, tired within several minutes The symptom, referred to as forerunner's syndrome such as tired.The typical symptom of esophagitis is for swallowing pain or retrosternal pain.After being common in radiotherapy 1 week or interior appearance several weeks, general symptom is lighter.Severe patient may occur in which chest severe pain, generates heat, chokes and cough, dyspnea, vomit, vomit Blood etc., should watch out for the generation of perforation of esophagus or esophago-tracheal fistula.
Treatment acute radiation-induced esophagitis common on market be mostly Western medicine, burden of easily the intestines and stomach being taken.
Summary of the invention
For the reason of above-mentioned acute radiation-induced esophagitis, an object of the present invention is to provide one to treat acute putting Penetrating property esophagitis suck pill, have non-stimulated, effective, it is easy to the feature of acceptance, the present invention use the most normal The Chinese crude drug seen, as raw material, is fabricated by through special processing technique.
Another object of the present invention is just to provide the above-mentioned preparation method sucking pill.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treatment acute radiation-induced esophagitis suck pill, the weight proportion of each crude drug is as follows, is weight portion:
Tremella 20-30 Herba Hedyotidis Diffusae 5-15 Radix Rhodiolae 5-15
Concha Ostreae 6-16 Herba Boschniakiae Rossicae 10-20 Rhizoma Acori Graminei 15-25
Citrus aurantium L. var. amara Engl. 1-5 Endothelium Corneum Gigeriae Galli 8-20 Herba Apii graveolentis 10-15
Herba cassiae occidentalis 2-6 Bulbus Allii essence 10-30 Semen Vitis viniferae 20-40
Pericarpium Citri Reticulatae Viride 6-13.
Aforementioned therapies acute radiation-induced esophagitis suck pill, preferred scheme, the weight proportion of each crude drug is as follows, It is weight portion:
Tremella 23-28 Herba Hedyotidis Diffusae 8-13 Radix Rhodiolae 8-13
Concha Ostreae 10-12 Herba Boschniakiae Rossicae 13-18 Rhizoma Acori Graminei 18-23
Citrus aurantium L. var. amara Engl. 2-4 Endothelium Corneum Gigeriae Galli 14-16 Herba Apii graveolentis 11-14
Herba cassiae occidentalis 3-5 Bulbus Allii essence 15-25 Semen Vitis viniferae 25-35
Pericarpium Citri Reticulatae Viride 8-10.
Aforementioned therapies acute radiation-induced esophagitis suck pill, more preferably preferably scheme, the weight proportion of each crude drug As follows, it is weight portion:
Tremella 25 Herba Hedyotidis Diffusae 11 Radix Rhodiolae 10
Concha Ostreae 11 Herba Boschniakiae Rossicae 15 Rhizoma Acori Graminei 20
Citrus aurantium L. var. amara Engl. 3 Endothelium Corneum Gigeriae Galli 15 Herba Apii graveolentis 13
Herba cassiae occidentalis 4 Bulbus Allii essence 20 Semen Vitis viniferae 30
Pericarpium Citri Reticulatae Viride 9.
The preparation method sucking pill for the treatment of acute radiation-induced esophagitis, step is as follows:
(1) by clean Concha Ostreae and Semen Vitis viniferae, being placed in and be calcined to crisp on smokeless stove fire, taking-up cools, and pulverizes 80-120 mesh Sieve stand-by；
(2) fresh Herba Apii graveolentis is removed leaf, clean, diced, put in juice extractor, juice extractor is opened, the fried 90-120 second, will Juice takes out puts into cup, and the mineral water dilution adding juice weight 0.2-0.6 times is stand-by；
(3) Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei are cleaned up, place 10-20 at shady and cool ventilative place little Time, the iron plate of burn-out smears last layer edible oil, the Tremella then made drying in the air, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei is placed on iron plate, repeatedly stir-fries 2-6 minute, puts into appropriate Sal during stir-frying, and dries in the air cool, grinds to form smalls Cross 100-140 mesh sieve；
(4) being soaked 40-60 minute by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine, filter, filtering residue boiling is extremely Boiling, turns slow fire boiling 12-18 minute, filters, and filtrate is stand-by；
(5) step (4) gained filtrate being placed in transparent container, first put into step (2) gained Sucus Oenanthes Javanicae, big fire is boiled, so After add step (1), (3) gained smalls and Bulbus Allii essence, slow fire is simmered 20-40 minute slowly, puts into the Mel refined, and uses big ferrum Spoon stirs clockwise, is processed into circle according to the preparation technology of pill.
The above-mentioned preparation method sucking pill, step (1) pulverized that 90-110 mesh sieve is stand-by (preferably, pulverized 100 mesh Sieve stand-by).
The above-mentioned preparation method sucking pill, step (2) adds the mineral water of juice weight 0.3-0.5 times and dilutes (preferably , add the mineral water dilution of juice weight 0.4 times).
The above-mentioned preparation method sucking pill, step (3) is by clear to Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei Wash clean, places 13-18 hour (preferably, by Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei at shady and cool ventilative place Clean up, place 15 hours at shady and cool ventilative place).
The above-mentioned preparation method sucking pill, step (3) stir-fries 3-5 minute repeatedly, puts into appropriate during stir-frying Sal (preferably, repeatedly stir-fry 4 minutes, put into appropriate Sal during stir-frying).
The above-mentioned preparation method sucking pill, Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine are soaked by step (4) Steep 45-55 minute (preferably, being soaked 50 minutes by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine).
The above-mentioned preparation method sucking pill, step (4) amount of water is that (preferably, amount of water is filter for 5-10 times of filtering residue 6-9 times of slag, the most preferably, amount of water is 7.5 times of filtering residue).
It is notable to treatment acute radiation-induced esophagitis effect that this sucks pill, has rapid-action, and the feature that cure rate is high is taken This is sucked pill and has not a particle of the sensation of discomfort, takes period stomach and has not a particle of excitement, and the present invention is many, and optionally side is common Medical material, cheap, alleviate the financial burden of patient.
The pharmacological effect of each crude drug is respectively as follows:
Tremella: Tremella is also tonic medicine simply, and feature is moist and oiliness stagnant, has spleen reinforcing appetizing, QI invigorating bowel relieving, sleeping strong Stomach, supplementing the brain, replenishing YIN and removing heat, the merit moisturized, the patient not nourished hyperactivity of fire caused by deficiency of YIN by ginseng and pilose antler Isothermal Hot is a kind of good tonic. Tremella is rich in natural characteristic colloid, adds its nourishing yin effect, and long-term taking with skin moistening, and can dispel face's chloasma, passeris montani saturati Effect of speckle.Tremella is kind of the diet food containing dietary fiber, and its dietary fiber can help gastrointestinal peristalsis, reduces fat absorption.
Herba Hedyotidis Diffusae: cure mainly: dyspnea and cough due to lung-heat；Laryngopharynx swelling and pain；Acute appendicitis；Furuncle and phyma skin infection；Venom；The puckery pain of pyretic stranguria；Water Swollen；Dysentery；Enteritis；Jaundice due to damp-heat；It is good at the multiple cancerous protuberance for the treatment of.
Radix Rhodiolae: nature and flavor: cold, sweet, puckery.Gui Jing: lung meridian.Function cures mainly: have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae to nourish heart, hemostasis with astringents, Effect of dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury Deng.
Concha Ostreae: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula expectorant Core, note of the ancient Chinese abdominal mass mass in the abdomen, spontaneous sweating, metrorrhagia and leukorrhagia of passing out semen, pantothenic acid of having a stomachache.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating, for spontaneous sweating, and metrorrhagia and leukorrhagia of passing out semen, Stomachache acid regurgitation.1, tonifying YIN YANG hyperactivity suppressing, agitation, insomnia, the dizziness headache caused for hyperactivity of YANG due to deficiency of YIN, one's ears rang and spots danced before one's eyes, hectic fever night sweat.2、 Restrain astringent or styptic treatment for spontaneous sweating, treat sweating due to debility, leukorrhagia, seminal emission.
3, hard masses softening and resolving, can treat and tie swollen, enclosed mass, phlegm-fire scrofula.
Herba Boschniakiae Rossicae: the herb of position Orobanchaceae Boschniakia plant plait Herba Cistanches.Composition: the sugary glycoside of herb: Herba Boschniakiae Rossicae phenylpropyl alcohol Enol glycosides A, B, C, D, Herba Boschniakiae Rossicae glycosides, boschniakine glycosides.Iridoid glycosides, acids: 8-table deoxygenates the sweet acid of Semen Strychni, Galla Turcica (Galla Helepensis) Acid, cinnamic acid, caffeic acid, P-coumaric acid, etc..Aerial parts contains Herba Cistanches aldin, and Herba Boschniakiae Rossicae lactone.The property of medicine: sweet, salty, warm. Function cures mainly: kidney invigorating and YANG supporting, loosening bowel to relieve constipation, hemostasis.Curing mainly impotence due to deficiency of the kidney, seminal emission, chills and pain of the waist and kness, urine loses drip, hematuria, cold womb Infertile, metrorrhagia, leukorrhagia, dryness of the intestine constipation.
Rhizoma Acori Graminei: another name Rhizoma Anemones Altaicae, water Rhizoma Acori Graminei, powder Chang, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek.Flavor efficacy: pungent, Put down or tepor.Enter the heart, liver, spleen channel.Fresh goods strong flavor, the pungent power dissipated more wins than dry product, therefore is the good merchantable brand declaring gas sensible.This Product be both longer than removing dampness by means of aromatics, activating spleen and strengthening stomach, were used for treating cloudy stagnant middle Jiao of turbid damp, functional activity of QI being not smooth, breast gastral cavity vexed swollen, anorexia is all Disease；And again can virtue China expectorant turbid, resuscitation inducing and mind tranquilizing, dazed and confused for treating the mind that turbid damp blinds caused by clear key, the disease of white and greasy fur； And arrogate to oneself and control expectorant heat and fall the diseases such as the unconsciousness caused by stagnant pericardium, tic.
Citrus aurantium L. var. amara Engl.: the traditional Chinese medical science is referred to as Herba Adonidis.It has the function of heart tonifying, diuresis, calmness and decreased heart rate, can reduce god Through irritability and the spinal reflex superfunction of system, for acute disease and chronic cardiac insufficiency.Cure mainly congestive heart failure Exhaust, cardiac edema and auricular fibrillation, the therapeutical effect to epileptics can be strengthened with share of Silver monobromide.Function master Control: promoting the circulation of QI to alleviate the stagnation in middle-JIAO, help digestion, reduce phlegm.For the vexed distending pain of chest and abdomen, accumulation of food in the stomach and intes tine due to indigestion, phlegm retention, proctoptosis, soothing the liver, stomach function regulating, regulate the flow of vital energy.Control in the heart Painful abdominal mass is vexed, abdominal distention, vomits, eats less.
Endothelium Corneum Gigeriae Galli: for the gizzard tunica intima of Phasianidae Phasianus animal man chicken.Composition: Endothelium Corneum Gigeriae Galli contains pepsine, keratin, trace stomach Protease, amylase, multivitamin.The chicken gizzard tunica intima in class origin 4-8 week is possibly together with bilitrien and the Huang of biliverdin Color derivant etc..The property of medicine: sweet, puckery, flat.Return spleen, stomach, bladder warp.Function cures mainly: strengthening the spleen and stomach, helps digestion long-pending, fossil.Cure mainly food stagnation, Have loose bowels, infantile malnutrition, cholelithiasis, stranguria caused by urinary stone, Sha Lin, lump in the abdomen amenorrhea, sore throat tonsillitis, ulcerative gingivitis aphtha.
Herba cassiae occidentalis: dulcitol i.e. galactitol, is all isomer with mannitol, sorbitol, little (21%) quilt in human body Metabolism, it is impossible to alleviate insulin shock, the most do not cause glycosuria, the predecessor of liver glycogen can be made rat.Nature and flavor: puckery, temperature.Function Cure mainly: dredge the meridian passage, expelling wind and removing dampness.Treating rheumatic joint capsule, lumbar muscle strain, body nihility power.
Bulbus Allii essence: 1, reduce cholesterol and blood fat, strengthen blood vessel elasticity and reduce blood pressure, lower platelet aggregation and can subtract Few heart attack.2, having strong disinfecting effect, especially suitable lung, the infection of stomach and microorganism are infected.3, blood can be regulated Sugar, reduces diabetes onset.4 and fat combine, bowel relieving, detoxification, purify the blood liquid, removes the impurity in health.5, gumming is effectively gone Thorn, reduces and infects.6, it is applicable to fever, pain relieving, coughs, have sore throat and the cold symptoms such as nasal obstruction.
Semen Vitis viniferae: protection cardiovascular and cerebrovascular vessel, reduces cholesterol, prevents arteriosclerosis, prevention cerebral hemorrhage, apoplexy, hemiplegia etc.；Dimension Hold the permeability of blood capillary appropriateness, increase blood vessel intensity, lower blood capillary fragility；
Blood fat reducing, blood pressure lowering, the formation of suppression thrombosis, reduces the generation of fatty liver；Prevention blood vessel wall fragility cause edema, blood Silk；Alleviate edema and leg swelling, alleviate bruise, sports injuries；Improve varicosis, venous insufficiency, phlebitis, anti- Control capillary hemorrhage.
Herba Apii graveolentis: Herba Apii graveolentis, belongs to samphire.Having Herba Oenanthes Javanicae, Herba Apii graveolentis, Herba Apii graveolentis three kinds, function is close, medicinal is preferred with Herba Apii graveolentis. Herba Apii graveolentis fragrance is denseer, claims " medicine celery ".But with Herba Coriandri is not a kind, Herba Apii graveolentis rich in proteins, carbohydrate, carotene, Vitamin B group, calcium, phosphorus, ferrum, sodium etc., meanwhile, have and have calming liver and clearing heat, expelling wind and removing dampness, and relieving restlessness is subsided a swelling, cooling blood for hemostasis, removing toxic substances a surname Lung, stomach invigorating profit blood, bowel relieving are convenient, nourishing the lung to arrest cough, reduce blood pressure, effect that brain-strengthening is calm.Often eat Herba Apii graveolentis, especially eat Herba Apii graveolentis Leaf, the most highly beneficial to prophylaxis of hypertension, arteriosclerosis etc., and have auxiliary therapeutic action.
Pericarpium Citri Reticulatae Viride: base: for Rutaceae mandarin tree plant Fructus Citri tangerinae and the young fruit of variety thereof or the peel of immature fruit.Become Point: Pericarpium Citri Reticulatae Viride is containing boosting effective ingredient: left-handed Neosynephrine acetate；Also containing aspartic acid, glutamic acid, proline, glycine, the third ammonia Acid, cystine, leucine, isoleucine, phenylalanine etc..The property of medicine: bitter, pungent, temperature.Return liver, gallbladder, stomach warp.Function cures mainly: soothing the liver Dispelling the stagnated QI, removing food stagnancyization is stagnant.Cure mainly the side of body rib, breast, epigastric distending pain, nodule in the breast, acute mastitis, hernia, food stagnation, lump in the abdomen, chronic malaria addiction block.
The present invention sucks pill and debates the principle of disease treatment, existing treatment acute radiation in the medical material of selection based on Chinese medicine The medicine of property esophagitis, by Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Concha Ostreae, Herba Boschniakiae Rossicae, Rhizoma Acori Graminei, Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba Apii graveolentis, Herba cassiae occidentalis, Bulbus Allii essence, Semen Vitis viniferae and these heat-clearing and toxic substances removing of Pericarpium Citri Reticulatae Viride, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling, detumescence and promoting granulation, regulate the flow of vital energy and in, again The drug regimen of body immunity can be improved together, the crude drug of various effects cooperate together preparation cost invention Suck pill for external, treatment acute radiation-induced esophagitis is had fabulous therapeutical effect.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited by this.
What embodiment 1 treated acute radiation-induced esophagitis sucks pill, takes off and states the crude drug of weight proportion and be prepared from (every part takes 10g):
Tremella 5 parts of Radix Rhodiolaes of 20 parts of Herba Hedyotidis Diffusaes 5 parts
Concha Ostreae 10 portions of Rhizoma Acori Gramineis of 6 portions of Herba Boschniakiae Rossicaes 15 parts
Citrus aurantium L. var. amara Engl. 8 portions of Herba Apii graveolentis of 1 part of Endothelium Corneum Gigeriae Galli 10 parts
2 parts of Bulbus Allii 10 parts of Semen Vitis viniferae of essence of Herba cassiae occidentalis 20 parts
6 parts of Pericarpium Citri Reticulatae Viride.
The preparation method sucking pill of above-mentioned treatment acute radiation-induced esophagitis, step is:
(1) by clean Concha Ostreae and Semen Vitis viniferae, being placed in and be calcined to crisp on smokeless stove fire, taking-up cools, and pulverized 80 mesh sieves and treats With；
(2) fresh Herba Apii graveolentis is removed leaf, clean, diced, put in juice extractor, juice extractor is opened, fried 90 seconds, by juice Cup is put in taking-up, and the mineral water dilution adding juice weight 0.2 times is stand-by；
(3) Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei are cleaned up, place 10 hours at shady and cool ventilative place, The iron plate of burn-out is smeared last layer edible oil, the Tremella then made drying in the air, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Chang Pu is placed on iron plate, repeatedly stir-fries 2 minutes, puts into appropriate Sal during stir-frying, dry in the air cool, grinds to form smalls mistake 100 mesh sieves；
(4) being soaked 40 minutes by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine, filter, filtering residue boiling is to boiling Rising, turn slow fire boiling 12 minutes, filter, filtrate is stand-by；
(5) step (4) gained filtrate being placed in transparent container, first put into step (2) gained Sucus Oenanthes Javanicae, big fire is boiled, so After add step (1), (3) gained smalls and Bulbus Allii essence, slow fire is simmered slowly 20 minutes, is put into the Mel refined, with big ferrum spoon Stir clockwise, be processed into circle according to the preparation technology of pill.
What embodiment 2 treated acute radiation-induced esophagitis sucks pill, takes off and states the crude drug of weight proportion and be prepared from (every part takes 15g):
Tremella 15 parts of Radix Rhodiolaes of 30 parts of Herba Hedyotidis Diffusaes 15 parts
Concha Ostreae 20 portions of Rhizoma Acori Gramineis of 16 portions of Herba Boschniakiae Rossicaes 25 parts
Citrus aurantium L. var. amara Engl. 20 portions of Herba Apii graveolentis of 5 parts of Endothelium Corneum Gigeriae Galli 15 parts
6 parts of Bulbus Allii 30 parts of Semen Vitis viniferae of essence of Herba cassiae occidentalis 40 parts
13 parts of Pericarpium Citri Reticulatae Viride.
The preparation method sucking pill of above-mentioned treatment acute radiation-induced esophagitis, step is:
(1) by clean Concha Ostreae and Semen Vitis viniferae, being placed in and be calcined to crisp on smokeless stove fire, taking-up cools, and pulverized 120 mesh sieves and treats With；
(2) fresh Herba Apii graveolentis is removed leaf, clean, diced, put in juice extractor, juice extractor is opened, fried 120 seconds, by juice Liquid takes out puts into cup, and the mineral water dilution adding juice weight 0.6 times is stand-by；
(3) Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei are cleaned up, place 20 hours at shady and cool ventilative place, The iron plate of burn-out is smeared last layer edible oil, the Tremella then made drying in the air, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Chang Pu is placed on iron plate, repeatedly stir-fries 6 minutes, puts into appropriate Sal during stir-frying, dry in the air cool, grinds to form smalls mistake 140 mesh sieves；
(4) being soaked 60 minutes by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine, filter, filtering residue boiling is to boiling Rising, turn slow fire boiling 18 minutes, filter, filtrate is stand-by；
(5) step (4) gained filtrate being placed in transparent container, first put into step (2) gained Sucus Oenanthes Javanicae, big fire is boiled, so After add step (1), (3) gained smalls and Bulbus Allii essence, slow fire is simmered slowly 40 minutes, is put into the Mel refined, with big ferrum spoon Stir clockwise, be processed into circle according to the preparation technology of pill.
Embodiment 3: treatment acute radiation-induced esophagitis suck pill, take off and state the crude drug of weight proportion and be prepared from (every part takes 20g):
Tremella 8 parts of Radix Rhodiolaes of 23 parts of Herba Hedyotidis Diffusaes 8 parts
Concha Ostreae 13 portions of Rhizoma Acori Gramineis of 10 portions of Herba Boschniakiae Rossicaes 18 parts
Citrus aurantium L. var. amara Engl. 14 portions of Herba Apii graveolentis of 2 parts of Endothelium Corneum Gigeriae Galli 11 parts
3 parts of Bulbus Allii 15 parts of Semen Vitis viniferae of essence of Herba cassiae occidentalis 25 parts
8 parts of Pericarpium Citri Reticulatae Viride.
The preparation method sucking pill of above-mentioned treatment acute radiation-induced esophagitis, step is:
(1) by clean Concha Ostreae and Semen Vitis viniferae, being placed in and be calcined to crisp on smokeless stove fire, taking-up cools, and pulverized 90 mesh sieves and treats With；
(2) fresh Herba Apii graveolentis is removed leaf, clean, diced, put in juice extractor, juice extractor is opened, fried 100 seconds, by juice Liquid takes out puts into cup, and the mineral water dilution adding juice weight 0.3 times is stand-by；
(3) Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei are cleaned up, place 13 hours at shady and cool ventilative place, The iron plate of burn-out is smeared last layer edible oil, the Tremella then made drying in the air, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Chang Pu is placed on iron plate, repeatedly stir-fries 3 minutes, puts into appropriate Sal during stir-frying, dry in the air cool, grinds to form smalls mistake 110 mesh sieves；
(4) being soaked 45 minutes by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine, filter, filtering residue boiling is to boiling Rising, turn slow fire boiling 13 minutes, filter, filtrate is stand-by；
(5) step (4) gained filtrate being placed in transparent container, first put into step (2) gained Sucus Oenanthes Javanicae, big fire is boiled, so After add step (1), (3) gained smalls and Bulbus Allii essence, slow fire is simmered slowly 25 minutes, is put into the Mel refined, with big ferrum spoon Stir clockwise, be processed into circle according to the preparation technology of pill.
What embodiment 4 treated acute radiation-induced esophagitis sucks pill, takes off and states the crude drug of weight proportion and be prepared from (every part takes 25g):
Tremella 13 parts of Radix Rhodiolaes of 28 parts of Herba Hedyotidis Diffusaes 13 parts
Concha Ostreae 18 portions of Rhizoma Acori Gramineis of 12 portions of Herba Boschniakiae Rossicaes 23 parts
Citrus aurantium L. var. amara Engl. 16 portions of Herba Apii graveolentis of 4 parts of Endothelium Corneum Gigeriae Galli 14 parts
5 parts of Bulbus Allii 25 parts of Semen Vitis viniferae of essence of Herba cassiae occidentalis 35 parts
10 parts of Pericarpium Citri Reticulatae Viride.
The preparation method sucking pill of above-mentioned treatment acute radiation-induced esophagitis, step is:
(1) by clean Concha Ostreae and Semen Vitis viniferae, being placed in and be calcined to crisp on smokeless stove fire, taking-up cools, and pulverized 110 mesh sieves and treats With；
(2) fresh Herba Apii graveolentis is removed leaf, clean, diced, put in juice extractor, juice extractor is opened, fried 110 seconds, by juice Liquid takes out puts into cup, and the mineral water dilution adding juice weight 0.5 times is stand-by；
(3) Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei are cleaned up, place 18 hours at shady and cool ventilative place, The iron plate of burn-out is smeared last layer edible oil, the Tremella then made drying in the air, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Chang Pu is placed on iron plate, repeatedly stir-fries 5 minutes, puts into appropriate Sal during stir-frying, dry in the air cool, grinds to form smalls mistake 130 mesh sieves；
(4) being soaked 55 minutes by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine, filter, filtering residue boiling is to boiling Rising, turn slow fire boiling 17 minutes, filter, filtrate is stand-by；
(5) step (4) gained filtrate being placed in transparent container, first put into step (2) gained Sucus Oenanthes Javanicae, big fire is boiled, so After add step (1), (3) gained smalls and Bulbus Allii essence, slow fire is simmered slowly 35 minutes, is put into the Mel refined, with big ferrum spoon Stir clockwise, be processed into circle according to the preparation technology of pill.
Embodiment 5: treatment acute radiation-induced esophagitis suck pill, take off state weight proportion crude drug preparation and Become (every part takes 30g):
Tremella 11 parts of Radix Rhodiolaes of 25 parts of Herba Hedyotidis Diffusaes 10 parts
Concha Ostreae 15 portions of Rhizoma Acori Gramineis of 11 portions of Herba Boschniakiae Rossicaes 20 parts
Citrus aurantium L. var. amara Engl. 15 portions of Herba Apii graveolentis of 3 parts of Endothelium Corneum Gigeriae Galli 13 parts
4 parts of Bulbus Allii 20 parts of Semen Vitis viniferae of essence of Herba cassiae occidentalis 30 parts
9 parts of Pericarpium Citri Reticulatae Viride.
The preparation method sucking pill of above-mentioned treatment acute radiation-induced esophagitis, step is:
(1) by clean Concha Ostreae and Semen Vitis viniferae, being placed in and be calcined to crisp on smokeless stove fire, taking-up cools, and pulverized 100 mesh sieves and treats With；
(2) fresh Herba Apii graveolentis is removed leaf, clean, diced, put in juice extractor, juice extractor is opened, fried 105 seconds, by juice Liquid takes out puts into cup, and the mineral water dilution adding juice weight 0.4 times is stand-by；
(3) Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei are cleaned up, place 15 hours at shady and cool ventilative place, The iron plate of burn-out is smeared last layer edible oil, the Tremella then made drying in the air, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Chang Pu is placed on iron plate, repeatedly stir-fries 4 minutes, puts into appropriate Sal during stir-frying, dry in the air cool, grinds to form smalls mistake 120 mesh sieves；
(4) being soaked 50 minutes by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine, filter, filtering residue boiling is to boiling Rising, turn slow fire boiling 16 minutes, filter, filtrate is stand-by；
(5) step (4) gained filtrate being placed in transparent container, first put into step (2) gained Sucus Oenanthes Javanicae, big fire is boiled, so After add step (1), (3) gained smalls and Bulbus Allii essence, slow fire is simmered slowly 30 minutes, is put into the Mel refined, with big ferrum spoon Stir clockwise, be processed into circle according to the preparation technology of pill.
Experimental example (embodiment 5 gained sucks pill): in order to verify that the present invention sucks the effect of pill, we are cured 4 Institute has extracted 400 patients and has carried out the experiment of medicine, test group 200 people, matched group 200 people, and experimental group takes embodiment 5 institute Must suck pill, matched group takes the medicine of other treatment treatment acute radiation-induced esophagitis.
Inclusion criteria: through being diagnosed as treatment acute radiation-induced esophagitis patient, have acute radiation-induced esophagitis clinical symptoms One or more.
Instructions of taking: taking the present invention every time and suck pill 1, one for several times, 5 days is a course for the treatment of, with good conditionsi permissible Take a period of time more.
Curative effect situation criterion: 1, curing, after taking this product, malaise symptoms is wholly absent；2, effective, take this product After, malaise symptoms alleviates or partial disappearance；3, invalid, after taking this product, malaise symptoms is unchanged.Experimental data is carried out by we Accurate statistics and mathematical analysis.Specific experiment result such as following table:
1: two group of Clinical efficacy comparison [example] table 1 of table
The present invention sucks pill has significant curative effect to treatment treatment acute radiation-induced esophagitis, and that can treat in various degree is acute Radiation esophagitis patient, effective percentage is up to 98%, and cure rate is up to 96%, and severe patient sucks pill taking gained of the present invention After 10 days, symptom also can alleviate, this invention to suck pill cheap, evident in efficacy, the present invention is that one treatment is anxious Property radiation esophagitis safety and without any side effects suck pill.

Claims (10)

1. that treats acute radiation-induced esophagitis sucks pill, it is characterised in that: the weight proportion of each crude drug is as follows, all attaches most importance to Amount part:
Tremella 20-30 Herba Hedyotidis Diffusae 5-15 Radix Rhodiolae 5-15
Concha Ostreae 6-16 Herba Boschniakiae Rossicae 10-20 Rhizoma Acori Graminei 15-25
Citrus aurantium L. var. amara Engl. 1-5 Endothelium Corneum Gigeriae Galli 8-20 Herba Apii graveolentis 10-15
Herba cassiae occidentalis 2-6 Bulbus Allii essence 10-30 Semen Vitis viniferae 20-40
Pericarpium Citri Reticulatae Viride 6-13.
That treats acute radiation-induced esophagitis the most according to claim 1 sucks pill, it is characterised in that: the weight of each crude drug Amount proportioning is as follows, is weight portion:
Tremella 23-28 Herba Hedyotidis Diffusae 8-13 Radix Rhodiolae 8-13
Concha Ostreae 10-12 Herba Boschniakiae Rossicae 13-18 Rhizoma Acori Graminei 18-23
Citrus aurantium L. var. amara Engl. 2-4 Endothelium Corneum Gigeriae Galli 14-16 Herba Apii graveolentis 11-14
Herba cassiae occidentalis 3-5 Bulbus Allii essence 15-25 Semen Vitis viniferae 25-35
Pericarpium Citri Reticulatae Viride 8-10.
That treats acute radiation-induced esophagitis the most according to claim 1 sucks pill, it is characterised in that: the weight of each crude drug Amount proportioning is as follows, is weight portion:
Tremella 25 Herba Hedyotidis Diffusae 11 Radix Rhodiolae 10
Concha Ostreae 11 Herba Boschniakiae Rossicae 15 Rhizoma Acori Graminei 20
Citrus aurantium L. var. amara Engl. 3 Endothelium Corneum Gigeriae Galli 15 Herba Apii graveolentis 13
Herba cassiae occidentalis 4 Bulbus Allii essence 20 Semen Vitis viniferae 30
Pericarpium Citri Reticulatae Viride 9.
4., according to the preparation method sucking pill for the treatment of acute radiation-induced esophagitis described in any one of claim 1-3, it is special Levy and be: step is as follows:
(1) by clean Concha Ostreae and Semen Vitis viniferae, being placed in and be calcined to crisp on smokeless stove fire, taking-up cools, and pulverizes 80-120 mesh Sieve stand-by；
(2) fresh Herba Apii graveolentis is removed leaf, clean, diced, put in juice extractor, juice extractor is opened, the fried 90-120 second, will Juice takes out puts into cup, and the mineral water dilution adding juice weight 0.2-0.6 times is stand-by；
(3) Tremella, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei are cleaned up, place 10-20 at shady and cool ventilative place little Time, the iron plate of burn-out smears last layer edible oil, the Tremella then made drying in the air, Herba Hedyotidis Diffusae, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei is placed on iron plate, repeatedly stir-fries 2-6 minute, puts into appropriate Sal during stir-frying, and dries in the air cool, grinds to form smalls Cross 100-140 mesh sieve；
(4) being soaked 40-60 minute by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine, filter, filtering residue boiling is extremely Boiling, turns slow fire boiling 12-18 minute, filters, and filtrate is stand-by；
(5) step (4) gained filtrate being placed in transparent container, first put into step (2) gained Sucus Oenanthes Javanicae, big fire is boiled, so After add step (1), (3) gained smalls and Bulbus Allii essence, slow fire is simmered 20-40 minute slowly, puts into the Mel refined, and uses big ferrum Spoon stirs clockwise, is processed into circle according to the preparation technology of pill.
Suck the preparation method of pill the most according to claim 4, it is characterised in that: step (1) pulverized 90-110 mesh sieve Stand-by (preferably, pulverizing 100 mesh sieves stand-by).
Suck the preparation method of pill the most according to claim 4, it is characterised in that: step (2) adds juice weight 0.3- The mineral water dilution (preferably, adding the mineral water dilution of juice weight 0.4 times) of 0.5 times.
Suck the preparation method of pill the most according to claim 4, it is characterised in that: step (3) is by Tremella, Herba Hedyotidis Diffusae Grass, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei clean up, and place 13-18 hour at shady and cool ventilative place (preferably, by Tremella, Agkistrodon SHECAO, Radix Rhodiolae, Herba Boschniakiae Rossicae and Rhizoma Acori Graminei clean up, and place 15 hours at shady and cool ventilative place).
Suck the preparation method of pill the most according to claim 4, it is characterised in that: step (3) stir-fries 3-5 minute repeatedly, During stir-frying, put into appropriate Sal (preferably, repeatedly stir-fry 4 minutes, during stir-frying, put into appropriate food Salt).
Suck the preparation method of pill the most according to claim 4, it is characterised in that: step (4) by Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride light salt brine soak 45-55 minute (preferably, by the light salt of Citrus aurantium L. var. amara Engl., Endothelium Corneum Gigeriae Galli, Herba cassiae occidentalis and Pericarpium Citri Reticulatae Viride Water soaking 50 minutes).
Suck the preparation method of pill the most according to claim 4, it is characterised in that: step (4) amount of water is the 5-of filtering residue 10 times (preferably, amount of water is 6-9 times of filtering residue, and the most preferably, amount of water is 7.5 times of filtering residue).
CN201610283174.2A 2016-05-03 2016-05-03 Buccal pill for treating acute radiation esophagitis and preparation method Pending CN105748854A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103638320A (en) * 2013-12-15 2014-03-19 冯庆亮 Traditional Chinese medicinal preparation for treating acute radiation-induced esophagitis
CN104435413A (en) * 2014-09-19 2015-03-25 刘兴旺 Externally-applied wet tissue for treating measles and preparation method thereof
CN104606669A (en) * 2015-03-05 2015-05-13 高霞 Rotula for promoting skeleton development of children and preparation method of rotula
CN104873947A (en) * 2015-06-17 2015-09-02 张建国 Medicinal composition for treating dog acute upper gastrointestinal hemorrhage and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103638320A (en) * 2013-12-15 2014-03-19 冯庆亮 Traditional Chinese medicinal preparation for treating acute radiation-induced esophagitis
CN104435413A (en) * 2014-09-19 2015-03-25 刘兴旺 Externally-applied wet tissue for treating measles and preparation method thereof
CN104606669A (en) * 2015-03-05 2015-05-13 高霞 Rotula for promoting skeleton development of children and preparation method of rotula
CN104873947A (en) * 2015-06-17 2015-09-02 张建国 Medicinal composition for treating dog acute upper gastrointestinal hemorrhage and preparation method thereof

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Application publication date: 20160713

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